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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZG16 Gene

protein-coding GIFtS: 44
GCID: GC16P029790

zymogen granule protein 16

(Previous names: jacalin-like lectin domain containing, zymogen granule...)
(Previous symbol: JCLN)

Explore 3 diseases affiliated with
ZG16 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zymogen Granule Protein 16¹ ² ³		HZG16¹
JCLN¹ ²		Secretory Lectin ZG16² ³
JCLN1¹ ²		Zymogen Granule Protein 16 Homolog (Rat)¹
ZG16A¹ ²		Zymogen Granule Membrane Protein 16²
Jacalin-Like Lectin Domain Containing¹ ²		Zymogen Granule Protein 16 Homolog²

External Ids:	HGNC: 30961¹	Entrez Gene: 653808²	Ensembl: ENSG00000174992⁷	UniProtKB: O60844³

Export aliases for ZG16 gene to outside databases

Previous GC identifers: GC16M028630 GC16P030113 GC16P029788 GC16P029828 GC16P9F0076 GC16P029699 GC16P9G0076 GC16P027450

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZG16_HUMAN, O60844

Function: May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the

luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZG16 gene promoter:
STAT1 RFX1 Spz1 GATA-3 STAT1beta FOXD1 Lmo2 STAT1alpha Evi-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ZG16

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZG16

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2

ZG16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZG16 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P029790: view genomic region (about GC identifiers)

Start:	29,789,561 bp from pter	End:	29,793,096 bp from pter
Size:	3,536 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZG16_HUMAN, O60844 (See protein sequence)

Recommended Name: Zymogen granule membrane protein 16 precursor

Size: 167 amino acids; 18177 Da

Subcellular location: Secreted, extracellular space, extracellular matrix. Cytoplasmic vesicle lumen (Probable). Golgi

apparatus lumen. Note=Stored in zymogen granules (By similarity)

1 PDB 3D structure from and Proteopedia for ZG16:

3APA (3D)

Secondary accessions: B2R4Z3 B9EK72

Explore the universe of human proteins at neXtProt for ZG16: NX_O60844

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60844

ZG16 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689551.2

ENSEMBL proteins:

ENSP00000383563

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Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005796	Golgi lumen	IDA	17307141
GO:0031012	extracellular matrix	IDA	17307141
GO:0042589	zymogen granule membrane	IEA	--
GO:0060205	cytoplasmic membrane-bounded vesicle lumen	IEA	--

ZG16 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZG16 for domains About GeneDecksing

1 InterPro domain/family:

IPR001229 Mannose-bd_lectin

Graphical View of Domain Structure for InterPro Entry O60844

ProtoNet protein and cluster: O60844

1 Blocks protein family: IPB001229 Jacalin-related lectin

UniProtKB/Swiss-Prot: ZG16_HUMAN, O60844

Similarity: Belongs to the jacalin lectin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZG16_HUMAN, O60844

Function: May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the

luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030246	carbohydrate binding	--	--

ZG16 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Zg16^tm1Lex for ZG16
     1 MGI phenotypic allele

for Zg16 (no phenotypes)

ZG16 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZG16

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for ZG16 (O60844^{2, 3} ENSP00000383563⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HBP1	O60381²^,³, ENSP00000222574⁴	MINT-2878488 I2D: score=1 STRING: ENSP00000222574
UBQLN4	Q9NRR5²^,³, ENSP00000357292⁴	MINT-2878469 I2D: score=2 STRING: ENSP00000357292
SGTA	O43765²^,³, ENSP00000221566⁴	MINT-66848 I2D: score=2 STRING: ENSP00000221566
UBQLN1	Q9UMX0³, ENSP00000365576⁴	I2D: score=1 STRING: ENSP00000365576
SUGT1	ENSP00000367208⁴	STRING: ENSP00000367208

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015031	protein transport	TAS	17307141

ZG16 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZG16
Search CenterWatch for drugs/clinical trials and news about ZG16

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZG16 gene:

NM_152338.3

Unigene Cluster for ZG16:

Zymogen granule protein 16

Hs.632195 [show with all ESTs]

Unigene Representative Sequence: AK125559

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000400752(uc002dtr.4)

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Additional cDNA sequence:

AB092813.1 AK125559.1 AK312002.1 BC029149.1 BC150656.1

1 DOTS entry:

DT.310247

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZG16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ZG16 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pancreas

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZG16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZG16

SOURCE GeneReport for Unigene cluster: Hs.632195

UniProtKB/Swiss-Prot: ZG16_HUMAN, O60844

Tissue specificity: Highly expressed in liver. Detected at lower levels in colon, ileum and jejunum

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZG16 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zg16^{1 , 5}	zymogen granule protein 16^{1, 5}	82.83(n)¹ 83.23(a)¹		7 (69.30 cM)⁵ 69036¹ NM_026918.2¹ NP_081194.1¹ 127050156⁵
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	76(a) 51(a) (see all 3)	many → 1 many → 1 (see all 3)	GL343606.1(170917-172526) GL343606.1(179481-181885)

ENSEMBL Gene Tree for ZG16 (if available)
TreeFam Gene Tree for ZG16 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZG16 gene

ZG16B²

3 SIMAP similar genes for ZG16 using alignment to 1 protein entry: ZG16_HUMAN:

EECP PAUF ZG16B

ZG16 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148819536^1,2	C,	--	29787587(+)	`TGGGCA/GGCCTA`	1	--	us2k¹		0	--	--	--	--
rs11861778^1,2	H	--	29787883(+)	`tcccaG/Tcactt`	1	--	us2k¹		0	--	--	--	--
rs183668672^1,2		--	29788059(+)	`TGGGAA/GGCAGA`	1	--	us2k¹		0	--	--	--	--
rs202222856^1,2		--	29788292(+)	`CTCAG-/CTCA AGTGATCCTCTT`	1	--	us2k¹		0	--	--	--	--
rs235657^1,2	C,A,	--	29788463(+)	`AGTGCT/CGGGAT`	1	--	us2k¹		4		NA WA CSA	7
rs235658^1,2	C,A,	--	29788474(+)	`TACAGC/GCATGA`	1	--	us2k¹		5		NA WA CSA	9
rs144734879^1,2		--	29788478(+)	`GGCATG/TAGCCA`	1	--	us2k¹		0	--	--	--	--
rs200257481^1,2		--	29788512(+)	`TTCTT-/TTGTTTTT`	1	--	us2k¹		0	--	--	--	--
rs148621006^1,2	C,	--	29788513(+)	`TCTTT-/TGTTTTT`	1	--	us2k¹		0	--	--	--	--
rs664975^1,2	C	--	29788514(+)	`CTTTTT/GTTTTT`	1	--	us2k¹		2		NA CSA	4

HapMap Linkage Disequilibrium report for ZG16 (29789561 - 29793096 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZG16
2 CNVs: 4939 35383

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZG16 for disorders About GeneDecksing

3 diseases for ZG16: About MalaCards

hepatocellular carcinoma ataxia carcinoma

Export disorders for ZG16 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZG16 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ZG16)

Utopia: connect your pdf to the dynamic
world of online information

Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related beta-prism fold. (PubMed id 21110947)^{1, 2} Kanagawa M.... Yamaguchi Y. (2011)
hZG16, a novel human secreted protein expressed in liver, was down-regulated in hepatocellular carcinoma. (PubMed id 17307141)^{1, 2} Zhou Y.B....Han Z.G. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)^{1, 2} Loftus B.J.... Adams M.D. (1999)
Human ZG16p recognizes pathogenic fungi through non-se lf polyvalent mannose in the digestive system. (PubMed id 21893569)¹ Tateno H....Hirabayashi J. (2012)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)¹ Lim J.... Zoghbi H.Y. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 653808	HGNC: 30961	Ensembl:ENSG00000174992	euGenes: HUgn653808	ECgene: ZG16
H-InvDB: ZG16

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZG16	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZG16 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZG16 gene:
Search GeneIP for patents involving ZG16

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZG16 gene at Home site.

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ZG16 Gene

zymogen granule protein 16

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ZG16 Gene

zymogen granule protein 16

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