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Aliases for ZG16 Gene

Aliases for ZG16 Gene

  • Zymogen Granule Protein 16 2 3 4 5
  • Jacalin-Like Lectin Domain Containing 2 3
  • Secretory Lectin ZG16 3 4
  • Zymogen Granule Protein 16 Homolog (Rat) 2
  • Zymogen Granule Protein 16 Homolog 3
  • JCLN1 3
  • ZG16A 3
  • HZG16 4
  • JCLN 3

External Ids for ZG16 Gene

Previous HGNC Symbols for ZG16 Gene

  • JCLN

Previous GeneCards Identifiers for ZG16 Gene

  • GC16M028630
  • GC16P030113
  • GC16P029788
  • GC16P029828
  • GC16P9F0076
  • GC16P029699
  • GC16P9G0076
  • GC16P029790
  • GC16P027450

Summaries for ZG16 Gene

GeneCards Summary for ZG16 Gene

ZG16 (Zymogen Granule Protein 16) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is ZG16B.

UniProtKB/Swiss-Prot for ZG16 Gene

  • May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZG16 Gene

Genomics for ZG16 Gene

Regulatory Elements for ZG16 Gene

Enhancers for ZG16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZG16 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZG16 Gene

29,760,827 bp from pter
29,782,973 bp from pter
22,147 bases
Plus strand

Genomic View for ZG16 Gene

Genes around ZG16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZG16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZG16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZG16 Gene

Proteins for ZG16 Gene

  • Protein details for ZG16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zymogen granule membrane protein 16
    Protein Accession:
    Secondary Accessions:
    • B2R4Z3
    • B9EK72

    Protein attributes for ZG16 Gene

    167 amino acids
    Molecular mass:
    18147 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZG16 Gene

neXtProt entry for ZG16 Gene

Proteomics data for ZG16 Gene at MOPED

Post-translational modifications for ZG16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZG16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZG16 Gene

Domains & Families for ZG16 Gene

Protein Domains for ZG16 Gene

Suggested Antigen Peptide Sequences for ZG16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 jacalin-type lectin domain.
  • Belongs to the jacalin lectin family.
  • Contains 1 jacalin-type lectin domain.
  • Belongs to the jacalin lectin family.
genes like me logo Genes that share domains with ZG16: view

No data available for Gene Families for ZG16 Gene

Function for ZG16 Gene

Molecular function for ZG16 Gene

UniProtKB/Swiss-Prot Function:
May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.
genes like me logo Genes that share phenotypes with ZG16: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZG16 Gene

Localization for ZG16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZG16 Gene

Secreted, extracellular space, extracellular matrix. Cytoplasmic vesicle lumen. Golgi apparatus lumen. Note=Stored in zymogen granules. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for ZG16 Gene COMPARTMENTS Subcellular localization image for ZG16 gene
Compartment Confidence
extracellular 5
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for ZG16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031012 extracellular matrix IDA 17307141
GO:0060205 cytoplasmic membrane-bounded vesicle lumen IEA --
genes like me logo Genes that share ontologies with ZG16: view

Pathways & Interactions for ZG16 Gene

SuperPathways for ZG16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZG16 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZG16 Gene

Drugs & Compounds for ZG16 Gene

No Compound Related Data Available

Transcripts for ZG16 Gene

mRNA/cDNA for ZG16 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZG16 Gene

Zymogen granule protein 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZG16 Gene

No ASD Table

Relevant External Links for ZG16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZG16 Gene

mRNA expression in normal human tissues for ZG16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZG16 Gene

This gene is overexpressed in Colon - Transverse (x41.0) and Small Intestine - Terminal Ileum (x8.7).

Protein differential expression in normal tissues from HIPED for ZG16 Gene

This gene is overexpressed in Rectum (31.2), Colon (25.2), and Pancreatic juice (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZG16 Gene

SOURCE GeneReport for Unigene cluster for ZG16 Gene Hs.632195

mRNA Expression by UniProt/SwissProt for ZG16 Gene

Tissue specificity: Highly expressed in liver. Detected at lower levels in colon, ileum and jejunum.
genes like me logo Genes that share expression patterns with ZG16: view

Protein tissue co-expression partners for ZG16 Gene

- Elite partner

Primer Products

Orthologs for ZG16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZG16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZG16 35
  • 80.35 (n)
  • 79.47 (a)
ZG16 36
  • 80 (a)
(Canis familiaris)
Mammalia ZG16 35
  • 86.03 (n)
  • 88.62 (a)
ZG16 36
  • 89 (a)
(Mus musculus)
Mammalia Zg16 35
  • 82.83 (n)
  • 83.23 (a)
Zg16 16
Zg16 36
  • 84 (a)
(Pan troglodytes)
Mammalia ZG16 35
  • 99 (n)
  • 99.4 (a)
ZG16 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zg16 35
  • 82.63 (n)
  • 84.43 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
-- 36
  • 82 (a)
-- 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia ZG16 36
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
-- 36
  • 75 (a)
-- 36
  • 48 (a)
-- 36
  • 44 (a)
-- 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zg16 35
  • 58.81 (n)
  • 55.71 (a)
Species with no ortholog for ZG16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZG16 Gene

Gene Tree for ZG16 (if available)
Gene Tree for ZG16 (if available)

Paralogs for ZG16 Gene

Paralogs for ZG16 Gene

(3) SIMAP similar genes for ZG16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZG16: view

Variants for ZG16 Gene

Sequence variations from dbSNP and Humsavar for ZG16 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs235636 - 29,779,543(+) ATGGA(A/G)GTGGT reference, missense
rs235638 - 29,780,400(+) CCCCA(C/G)TAGCT reference, missense
VAR_070695 -
rs4016836 -- 29,771,002(+) GAAAC(-/TT)TTTTT intron-variant
rs8063128 -- 29,774,209(+) gaacc(C/T)gggag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZG16 Gene

Variant ID Type Subtype PubMed ID
dgv34n68 CNV Loss 17160897
nsv833186 CNV Loss 17160897

Variation tolerance for ZG16 Gene

Gene Damage Index Score: 2.50; 43.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZG16 Gene

Disorders for ZG16 Gene

Relevant External Links for ZG16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZG16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZG16 Gene

Publications for ZG16 Gene

  1. Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related beta-prism fold. (PMID: 21110947) Kanagawa M. … Yamaguchi Y. (Biochem. Biophys. Res. Commun. 2011) 2 3 4 67
  2. Defining the Interaction of Human Soluble Lectin ZG16p and Mycobacterial Phosphatidylinositol Mannosides. (PMID: 25919894) Hanashima S. … Yamaguchi Y. (Chembiochem 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system. (PMID: 21893569) Tateno H. … Hirabayashi J. (Glycobiology 2012) 3
  5. hZG16, a novel human secreted protein expressed in liver, was down- regulated in hepatocellular carcinoma. (PMID: 17307141) Zhou Y.B. … Han Z.G. (Biochem. Biophys. Res. Commun. 2007) 3

Products for ZG16 Gene

Sources for ZG16 Gene