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ZG16 Gene

protein-coding   GIFtS: 44
GCID: GC16P029790

Zymogen Granule Protein 16

(Previous names: jacalin-like lectin domain containing, zymogen granule protein...)
(Previous symbol: JCLN)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zymogen Granule Protein 161 2 3     JCLN12
JCLN1 2     ZG16A2
Jacalin-Like Lectin Domain Containing1 2     Zymogen Granule Membrane Protein 162
Secretory Lectin ZG162 3     Zymogen Granule Protein 16 Homolog2
Zymogen Granule Protein 16 Homolog (Rat)1     hZG163

External Ids:    HGNC: 309611   Entrez Gene: 6538082   Ensembl: ENSG000001749927   UniProtKB: O608443   

Export aliases for ZG16 gene to outside databases

Previous GC identifers: GC16M028630 GC16P030113 GC16P029788 GC16P029828 GC16P9F0076 GC16P029699 GC16P9G0076 GC16P027450


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZG16 Gene:
ZG16 (zymogen granule protein 16) is a protein-coding gene. Diseases associated with ZG16 include hepatocellular carcinoma, and ataxia. An important paralog of this gene is ZG16B.

UniProtKB/Swiss-Prot: ZG16_HUMAN, O60844
Function: May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on
the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in
the TGN




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZG16 gene promoter:
         STAT1   RFX1   Spz1   GATA-3   STAT1beta   FOXD1   Lmo2   STAT1alpha   Evi-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZG16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZG16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

ZG16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZG16 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P029790:  view genomic region     (about GC identifiers)

Start:
29,789,561 bp from pter      End:
29,793,096 bp from pter
Size:
3,536 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZG16_HUMAN, O60844 (See protein sequence)
Recommended Name: Zymogen granule membrane protein 16 precursor  
Size: 167 amino acids; 18177 Da
6 PDB 3D structures from and Proteopedia for ZG16:
3APA (3D)        3VY6 (3D)        3VY7 (3D)        3VZE (3D)        3VZF (3D)        3VZG (3D)    
Secondary accessions: B2R4Z3 B9EK72

Explore the universe of human proteins at neXtProt for ZG16: NX_O60844

Explore proteomics data for ZG16 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZG16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689551.2  
    ENSEMBL proteins: 
     ENSP00000383563  

    ZG16 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001229 Mannose-bd_lectin

    Graphical View of Domain Structure for InterPro Entry O60844

    ProtoNet protein and cluster: O60844

    1 Blocks protein domain: IPB001229 Jacalin-related lectin

    UniProtKB/Swiss-Prot: ZG16_HUMAN, O60844
    Similarity: Belongs to the jacalin lectin family


    ZG16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZG16_HUMAN, O60844
    Function: May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on
    the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in
    the TGN

    Phenotypes:
         1 MGI phenotypic allele for Zg16 (no phenotypes)


    ZG16 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zg16tm1Lex for ZG16

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZG16
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    hsa-miR-4314 hsa-miR-3142 hsa-miR-3161 hsa-miR-4251 hsa-miR-516a-3p hsa-miR-516b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZG16_HUMAN, O60844: Secreted, extracellular space, extracellular matrix. Cytoplasmic vesicle lumen (Probable).
    Golgi apparatus lumen. Note=Stored in zymogen granules (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus5

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005796Golgi lumen IDA17307141
    GO:0031012extracellular matrix IDA17307141
    GO:0042589zymogen granule membrane IEA--
    GO:0060205cytoplasmic membrane-bounded vesicle lumen IEA--

    ZG16 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZG16
    Interactions:

        Search GeneGlobe Interaction Network for ZG16

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ZG16 (O608442, 3 ENSP000003835634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HBP1O603812, 3, ENSP000002225744MINT-2878488 I2D: score=1 STRING: ENSP00000222574
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2878469 I2D: score=2 STRING: ENSP00000357292
    SGTAO437652, 3, ENSP000002215664MINT-66848 I2D: score=2 STRING: ENSP00000221566
    UBQLN1Q9UMX03, ENSP000003655764I2D: score=1 STRING: ENSP00000365576
    SUGT1ENSP000003672084STRING: ENSP00000367208
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport TAS17307141

    ZG16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZG16



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZG16 gene: 
    NM_152338.3  

    Unigene Cluster for ZG16:

    Zymogen granule protein 16
    Hs.632195  [show with all ESTs]
    Unigene Representative Sequence: AK125559
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000400752(uc002dtr.4)
    miRNA
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    hsa-miR-4314 hsa-miR-3142 hsa-miR-3161 hsa-miR-4251 hsa-miR-516a-3p hsa-miR-516b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AB092813.1 AK125559.1 AK312002.1 BC029149.1 BC150656.1 

    1 DOTS entry:

    DT.310247 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZG16 expression in normal human tissues (normalized intensities)      ZG16 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZG16 Expression
    About this image


    ZG16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Islets of Langerhans
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
     
     Colon (Gastrointestinal Tract)
    ZG16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZG16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632195

    UniProtKB/Swiss-Prot: ZG16_HUMAN, O60844
    Tissue specificity: Highly expressed in liver. Detected at lower levels in colon, ileum and jejunum

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZG16 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zg161 , 5 zymogen granule protein 161, 5 82.83(n)1
    83.23(a)1
      7 (69.30 cM)5
    690361  NM_026918.21  NP_081194.11 
     1270501565 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 5)
    Uncharacterized protein
    (see all 5)
    75(a)
    48(a)
    (see all 5)
    many → 1
    many → 1
    (see all 5)
    GL343606.1(167510-172772)
    GL343606.1(179481-181885)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia zg161 zymogen granule protein 16 58.81(n)
    55.71(a)
      100170438  XM_002943160.2  XP_002943206.2 


    ENSEMBL Gene Tree for ZG16 (if available)
    TreeFam Gene Tree for ZG16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZG16 gene
    ZG16B2  
    3 SIMAP similar genes for ZG16 using alignment to 1 protein entry:     ZG16_HUMAN:
    EECP    PAUF    ZG16B

    ZG16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZG16 (see all 102)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1488195361,2
    C--29787587(+) TGGGCA/GGCCTA 1 -- us2k10--------
    rs118617781,2
    H--29787883(+) tcccaG/Tcactt 1 -- us2k10--------
    rs1836686721,2
    --29788059(+) TGGGAA/GGCAGA 1 -- us2k10--------
    rs2022228561,2
    --29788292(+) CTCAG-/CTCA  
     AGTGATC
    CTCTT
    1 -- us2k10--------
    rs2356571,2
    C,A--29788463(+) agtgcT/Cgggat 1 -- us2k14Minor allele frequency- C:0.00NA WA CSA 7
    rs2356581,2
    C,A--29788474(+) tacagC/Gcatga 1 -- us2k15Minor allele frequency- G:0.00NA WA CSA 9
    rs1447348791,2
    --29788478(+) GGCATG/TAGCCA 1 -- us2k10--------
    rs6649751,2
    C--29788514(+) cttttT/Gttttt 1 -- us2k12Minor allele frequency- G:0.25NA CSA 4
    rs355812241,2
    C--29788514(-) AAAAA-/AC/C  
            
    AAAAG
    1 -- us2k10--------
    rs1483293231,2
    --29788595(+) CACTGA/CAACCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZG16 (29789561 - 29793096 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZG16:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv34n68CNV Loss17160897
    nsv833186CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZG16
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for ZG16:    About MalaCards
    hepatocellular carcinoma    ataxia    pancreatitis    endotheliitis


    ZG16 for disorders           About GeneDecksing


    Export disorders for ZG16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZG16 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ZG16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related beta-prism fold. (PubMed id 21110947)1, 2 Kanagawa M.... Yamaguchi Y. (Biochem. Biophys. Res. Commun. 2011)
    2. hZG16, a novel human secreted protein expressed in liver, was down- regulated in hepatocellular carcinoma. (PubMed id 17307141)1, 2 Zhou Y.B.... Han Z.G. (Biochem. Biophys. Res. Commun. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (Genomics 1999)
    7. Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system. (PubMed id 21893569)1 Tateno H....Hirabayashi J. (Glycobiology 2012)
    8. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 653808 HGNC: 30961 Ensembl:ENSG00000174992 euGenes: HUgn653808 ECgene: ZG16
    H-InvDB: ZG16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZG16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZG16 gene:
    Search GeneIP for patents involving ZG16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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