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Aliases for ZG16 Gene

Aliases for ZG16 Gene

  • Zymogen Granule Protein 16 2 3 4 5
  • Jacalin-Like Lectin Domain Containing 2 3
  • Secretory Lectin ZG16 3 4
  • Zymogen Granule Protein 16 Homolog (Rat) 2
  • Zymogen Granule Membrane Protein 16 3
  • Zymogen Granule Protein 16 Homolog 3
  • JCLN1 3
  • ZG16A 3
  • HZG16 4
  • JCLN 3

External Ids for ZG16 Gene

Previous HGNC Symbols for ZG16 Gene

  • JCLN

Previous GeneCards Identifiers for ZG16 Gene

  • GC16M028630
  • GC16P030113
  • GC16P029788
  • GC16P029828
  • GC16P9F0076
  • GC16P029699
  • GC16P9G0076
  • GC16P029790
  • GC16P027450

Summaries for ZG16 Gene

GeneCards Summary for ZG16 Gene

ZG16 (Zymogen Granule Protein 16) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ZG16B.

UniProtKB/Swiss-Prot for ZG16 Gene

  • May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.

Additional gene information for ZG16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZG16 Gene

Genomics for ZG16 Gene

GeneHancer (GH) Regulatory Elements for ZG16 Gene

Promoters and enhancers for ZG16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I029778 Promoter/Enhancer 1.2 EPDnew ENCODE 550.4 +18.5 18507 2.6 FOXA2 NFIB NEUROD1 SIN3A ZKSCAN1 TEAD3 ZNF121 CTBP1 GATA3 LCORL ZG16 TBX6 GC16P029781 GC16M029747
GH16I029760 Enhancer 0.6 ENCODE 550.8 +0.3 349 2.1 TFAP4 RFX1 RXRA NR2C1 HNF4G BCL6 ZBTB33 HNF4A NR2C2 ZG16 ENSG00000261367 GC16P029781 GC16M029747
GH16I029757 Enhancer 1 Ensembl ENCODE 0.8 -2.6 -2589 1.3 FOXA2 DMAP1 ZBTB40 YY1 ZNF121 ATF7 CREM THAP11 HMG20B RXRA MYLPF ZG16 C16orf54 GC16M029747
GH16I029765 Enhancer 1 ENCODE 0.8 +4.9 4868 0.9 PKNOX1 FOXA2 MLX ZFP64 ARID4B NEUROD1 DMAP1 ZNF48 ETS1 YY1 LOC613038 ZG16 GC16P029781 GC16M029747
GH16I029753 Enhancer 0.8 ENCODE dbSUPER 0.4 -6.4 -6354 1.5 NR2F1 JUNB DPF2 ZNF121 IKZF1 NBN ATF7 RUNX3 IKZF2 EGR2 ZG16 C16orf54 GC16M029747
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZG16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZG16 gene promoter:

Genomic Locations for ZG16 Gene

Genomic Locations for ZG16 Gene
22,147 bases
Plus strand

Genomic View for ZG16 Gene

Genes around ZG16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZG16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZG16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZG16 Gene

Proteins for ZG16 Gene

  • Protein details for ZG16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zymogen granule membrane protein 16
    Protein Accession:
    Secondary Accessions:
    • B2R4Z3
    • B9EK72

    Protein attributes for ZG16 Gene

    167 amino acids
    Molecular mass:
    18147 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZG16 Gene

neXtProt entry for ZG16 Gene

Post-translational modifications for ZG16 Gene

No Post-translational modifications

Other Protein References for ZG16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZG16 Gene

Domains & Families for ZG16 Gene

Gene Families for ZG16 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for ZG16 Gene

Suggested Antigen Peptide Sequences for ZG16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the jacalin lectin family.
  • Belongs to the jacalin lectin family.
genes like me logo Genes that share domains with ZG16: view

Function for ZG16 Gene

Molecular function for ZG16 Gene

UniProtKB/Swiss-Prot Function:
May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.

Gene Ontology (GO) - Molecular Function for ZG16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ZG16: view
genes like me logo Genes that share phenotypes with ZG16: view

Animal Models for ZG16 Gene

MGI Knock Outs for ZG16:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZG16 Gene

Localization for ZG16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZG16 Gene

Secreted, extracellular space, extracellular matrix. Cytoplasmic vesicle lumen. Golgi apparatus lumen. Note=Stored in zymogen granules. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZG16 gene
Compartment Confidence
extracellular 5
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for ZG16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005796 Golgi lumen IEA,IDA 17307141
GO:0031012 extracellular matrix IDA 17307141
genes like me logo Genes that share ontologies with ZG16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZG16 Gene

Pathways & Interactions for ZG16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZG16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport TAS 17307141
genes like me logo Genes that share ontologies with ZG16: view

No data available for Pathways by source and SIGNOR curated interactions for ZG16 Gene

Drugs & Compounds for ZG16 Gene

No Compound Related Data Available

Transcripts for ZG16 Gene

mRNA/cDNA for ZG16 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZG16 Gene

Zymogen granule protein 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZG16 Gene

No ASD Table

Relevant External Links for ZG16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZG16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZG16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZG16 Gene

This gene is overexpressed in Colon - Transverse (x41.0) and Small Intestine - Terminal Ileum (x8.7).

Protein differential expression in normal tissues from HIPED for ZG16 Gene

This gene is overexpressed in Rectum (31.2), Colon (25.2), and Pancreatic juice (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZG16 Gene

Protein tissue co-expression partners for ZG16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZG16 Gene:


SOURCE GeneReport for Unigene cluster for ZG16 Gene:


mRNA Expression by UniProt/SwissProt for ZG16 Gene:

Tissue specificity: Highly expressed in liver. Detected at lower levels in colon, ileum and jejunum.

Evidence on tissue expression from TISSUES for ZG16 Gene

  • Intestine(4.7)
genes like me logo Genes that share expression patterns with ZG16: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ZG16 Gene

Orthologs for ZG16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZG16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZG16 33 34
  • 99 (n)
(Canis familiaris)
Mammalia ZG16 33 34
  • 86.03 (n)
(Mus musculus)
Mammalia Zg16 33 16 34
  • 82.83 (n)
(Rattus norvegicus)
Mammalia Zg16 33
  • 82.63 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 82 (a)
-- 34
  • 73 (a)
-- 34
  • 73 (a)
(Bos Taurus)
Mammalia ZG16 33 34
  • 80.35 (n)
(Ornithorhynchus anatinus)
Mammalia ZG16 34
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 75 (a)
-- 34
  • 48 (a)
-- 34
  • 44 (a)
-- 34
  • 42 (a)
-- 34
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zg16 33
  • 58.81 (n)
Species where no ortholog for ZG16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZG16 Gene

Gene Tree for ZG16 (if available)
Gene Tree for ZG16 (if available)

Paralogs for ZG16 Gene

Paralogs for ZG16 Gene

(3) SIMAP similar genes for ZG16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZG16: view

Variants for ZG16 Gene

Sequence variations from dbSNP and Humsavar for ZG16 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000062616 -- 29,761,210(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000173760 -- 29,769,157(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000723396 -- 29,771,653(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000754404 -- 29,771,976(+) G/A genic_upstream_transcript_variant, intron_variant
rs1001012144 -- 29,765,303(+) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZG16 Gene

Variant ID Type Subtype PubMed ID
dgv34n68 CNV loss 17160897
nsv833186 CNV loss 17160897

Variation tolerance for ZG16 Gene

Gene Damage Index Score: 2.50; 43.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZG16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZG16 Gene

Disorders for ZG16 Gene

Additional Disease Information for ZG16

No disorders were found for ZG16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZG16 Gene

Publications for ZG16 Gene

  1. Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related β-prism fold. (PMID: 21110947) Kanagawa M … Yamaguchi Y (Biochemical and biophysical research communications 2011) 2 3 4 58
  2. hZG16, a novel human secreted protein expressed in liver, was down-regulated in hepatocellular carcinoma. (PMID: 17307141) Zhou YB … Han ZG (Biochemical and biophysical research communications 2007) 3 4 58
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 3 4 58

Products for ZG16 Gene

Sources for ZG16 Gene

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