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Aliases for ZFYVE9 Gene

Aliases for ZFYVE9 Gene

  • Zinc Finger, FYVE Domain Containing 9 2 3
  • Smad Anchor For Receptor Activation 3 4
  • Novel Serine Protease 3 4
  • MADHIP 3 4
  • SMADIP 3 4
  • Sara 3 4
  • NSP 3 4
  • MAD, Mothers Against Decapentaplegic Homolog (Drosophila) Interacting Protein, Receptor Activation Anchor 2
  • MAD, Mothers Against Decapentaplegic Homolog Interacting Protein, Receptor Activation Anchor 3
  • Mothers Against Decapentaplegic Homolog-Interacting Protein 4
  • Protein Phosphatase 1, Regulatory Subunit 173 3
  • Zinc Finger FYVE Domain-Containing Protein 9 3
  • Receptor Activation Anchor 4
  • MADH-Interacting Protein 3
  • Madh-Interacting Protein 4
  • Regulatory Subunit 173 2
  • Protein Phosphatase 1 2
  • PPP1R173 3
  • HSARA 4

External Ids for ZFYVE9 Gene

Previous Symbols for ZFYVE9 Gene

  • MADHIP

Summaries for ZFYVE9 Gene

Entrez Gene Summary for ZFYVE9 Gene

  • This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

GeneCards Summary for ZFYVE9 Gene

ZFYVE9 (Zinc Finger, FYVE Domain Containing 9) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include serine-type peptidase activity and 1-phosphatidylinositol binding. An important paralog of this gene is ZFYVE16.

UniProtKB/Swiss-Prot for ZFYVE9 Gene

  • Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.

Gene Wiki entry for ZFYVE9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFYVE9 Gene

Genomics for ZFYVE9 Gene

Genomic Location for ZFYVE9 Gene

Start:
52,142,094 bp from pter
End:
52,346,686 bp from pter
Size:
204,593 bases
Orientation:
Plus strand

Genomic View for ZFYVE9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFYVE9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFYVE9 Gene

Regulatory Elements for ZFYVE9 Gene

Proteins for ZFYVE9 Gene

  • Protein details for ZFYVE9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95405-ZFYV9_HUMAN
    Recommended name:
    Zinc finger FYVE domain-containing protein 9
    Protein Accession:
    O95405
    Secondary Accessions:
    • Q5T0F6
    • Q5T0F7
    • Q9UNE1
    • Q9Y5R7

    Protein attributes for ZFYVE9 Gene

    Size:
    1425 amino acids
    Molecular mass:
    156403 Da
    Quaternary structure:
    • Interacts (via the SBD region) with SMAD2; the interaction recruits SMAD2 to the TGF-beta receptor and is disrupted by phosphorylation of SMAD2 upon TGF-beta receptor activation. Interacts with SMAD3. Interacts with TGFBR1 and TGFBR2; the interaction recruits SMAD2 to the TGF-beta receptor. Interacts with PML.
    SequenceCaution:
    • Sequence=AAC99462.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD31694.1; Type=Frameshift; Positions=1243; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZFYVE9 Gene

    Alternative splice isoforms for ZFYVE9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFYVE9 Gene

Proteomics data for ZFYVE9 Gene at MOPED

Post-translational modifications for ZFYVE9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFYVE9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFYVE9 Gene

Domains for ZFYVE9 Gene

Gene Families for ZFYVE9 Gene

HGNC:
  • ZFYVE :Zinc fingers, FYVE domain containing

Protein Domains for ZFYVE9 Gene

UniProtKB/Swiss-Prot:

ZFYV9_HUMAN
Domain:
  • The SMAD binding domain (SBD) interacts with the MH2 domains of SMAD2 or SMAD3:
    • O95405
  • The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P:
    • O95405
Similarity:
  • Contains 1 FYVE-type zinc finger.:
    • O95405
genes like me logo Genes that share domains with ZFYVE9: view

Function for ZFYVE9 Gene

Molecular function for ZFYVE9 Gene

UniProtKB/Swiss-Prot Function: Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.

Gene Ontology (GO) - Molecular Function for ZFYVE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12154125
GO:0005545 1-phosphatidylinositol binding IDA 11877415
GO:0008236 serine-type peptidase activity NAS 9582421
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFYVE9: view

miRNA for ZFYVE9 Gene

miRTarBase miRNAs that target ZFYVE9

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFYVE9 Gene

Localization for ZFYVE9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFYVE9 Gene

Cytoplasm. Early endosome membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFYVE9 Gene COMPARTMENTS Subcellular localization image for ZFYVE9 gene
Compartment Confidence
endosome 5
cytosol 3
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ZFYVE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome NAS 12809483
GO:0031901 early endosome membrane TAS --
genes like me logo Genes that share ontologies with ZFYVE9: view

Pathways for ZFYVE9 Gene

genes like me logo Genes that share pathways with ZFYVE9: view

Gene Ontology (GO) - Biological Process for ZFYVE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 9582421
GO:0006897 endocytosis NAS 12809483
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0007183 SMAD protein complex assembly IDA 9865696
GO:0007184 SMAD protein import into nucleus IMP 9865696
genes like me logo Genes that share ontologies with ZFYVE9: view

Compounds for ZFYVE9 Gene

(8) Novoseek inferred chemical compound relationships for ZFYVE9 Gene

Compound -log(P) Hits PubMed IDs
serine 82.9 104
phosphatidylinositol 3-phosphate 68.2 1
fibrinogen 31.2 1
threonine 16.9 1
proline 13.7 2
genes like me logo Genes that share compounds with ZFYVE9: view

Transcripts for ZFYVE9 Gene

Unigene Clusters for ZFYVE9 Gene

Zinc finger, FYVE domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE9 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for ZFYVE9 Gene

GeneLoc Exon Structure for
ZFYVE9
ECgene alternative splicing isoforms for
ZFYVE9

Expression for ZFYVE9 Gene

mRNA expression in normal human tissues for ZFYVE9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFYVE9 Gene

SOURCE GeneReport for Unigene cluster for ZFYVE9 Gene Hs.532345

mRNA Expression by UniProt/SwissProt for ZFYVE9 Gene

O95405-ZFYV9_HUMAN
Tissue specificity: Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes
genes like me logo Genes that share expressions with ZFYVE9: view

Orthologs for ZFYVE9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFYVE9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFYVE9 36
  • 99.49 (n)
  • 99.3 (a)
ZFYVE9 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFYVE9 36
  • 92.56 (n)
  • 90.57 (a)
ZFYVE9 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFYVE9 36
  • 91.82 (n)
  • 90.51 (a)
ZFYVE9 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfyve9 36
  • 91.94 (n)
  • 97.71 (a)
Zfyve9 16
Zfyve9 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFYVE9 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 13 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Zfyve9 36
  • 87.74 (n)
  • 86.77 (a)
chicken
(Gallus gallus)
Aves ZFYVE9 36
  • 77.38 (n)
  • 78.16 (a)
ZFYVE9 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFYVE9 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia madhip-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7299 36
zfyve9 36
  • 70.7 (n)
  • 73.73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13130 36
zebrafish
(Danio rerio)
Actinopterygii BX511174.1 37
  • 55 (a)
ManyToMany
CR762408.1 37
  • 55 (a)
ManyToMany
zfyve9a 36
  • 70.73 (n)
  • 77.63 (a)
zfyve9a 37
  • 61 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAB1 37
  • 6 (a)
OneToMany
Species with no ortholog for ZFYVE9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFYVE9 Gene

ENSEMBL:
Gene Tree for ZFYVE9 (if available)
TreeFam:
Gene Tree for ZFYVE9 (if available)

Paralogs for ZFYVE9 Gene

Paralogs for ZFYVE9 Gene

Selected SIMAP similar genes for ZFYVE9 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZFYVE9 Gene

genes like me logo Genes that share paralogs with ZFYVE9: view

Variants for ZFYVE9 Gene

Sequence variations from dbSNP and Humsavar for ZFYVE9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs168311 -- 52,206,410(-) TCTCC(A/C)ATTTT intron-variant
rs180843 -- 52,192,047(+) TTCTA(A/G)AACAA intron-variant
rs180844 -- 52,240,992(+) tctaa(A/T)gtact intron-variant
rs186970 -- 52,264,043(-) CTGAA(A/G)TGCTA intron-variant
rs238147 -- 52,269,283(-) gcatg(A/G)tggca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFYVE9 Gene

Variant ID Type Subtype PubMed ID
esv25536 CNV Loss 19812545
nsv855 CNV Insertion 18451855
esv2748118 CNV Deletion 23290073
nsv819763 CNV Gain 19587683
esv2669236 CNV Deletion 23128226
nsv822553 CNV Loss 20364138
esv1012300 CNV Deletion 17803354

Relevant External Links for ZFYVE9 Gene

HapMap Linkage Disequilibrium report
ZFYVE9

Disorders for ZFYVE9 Gene

(14) Novoseek inferred disease relationships for ZFYVE9 Gene

Disease -log(P) Hits PubMed IDs
nephropathy iga 33.4 2
ovarian carcinoma 20.3 1
diabetic nephropathies 19.4 1
disseminated intravascular coagulation 16.6 1
metastasis 14 4

Relevant External Links for ZFYVE9

Genetic Association Database (GAD)
ZFYVE9
genes like me logo Genes that share disorders with ZFYVE9: view

No data available for UniProtKB/Swiss-Prot for ZFYVE9 Gene

Publications for ZFYVE9 Gene

  1. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. (PMID: 9865696) Tsukazaki T. … Wrana J.L. (Cell 1998) 2 3 4 23
  2. Identification of a novel serine protease-like molecule in human brain. (PMID: 9582421) Meckelein B. … Abraham C.R. (Brain Res. Mol. Brain Res. 1998) 3 4 23
  3. Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control. (PMID: 12154125) Qin B.Y. … Lin K. (Genes Dev. 2002) 3 4 23
  4. Cytoplasmic PML function in TGF-beta signalling. (PMID: 15356634) Lin H.K. … Pandolfi P.P. (Nature 2004) 3 4 23
  5. Early endosomal regulation of Smad-dependent signaling in endothelial cells. (PMID: 11877415) Panopoulou E. … Fotsis T. (J. Biol. Chem. 2002) 3 4 23

Products for ZFYVE9 Gene

  • antibodies-online proteins for ZFYVE9
  • antibodies-online antibodies for ZFYVE9
  • antibodies-online kits for ZFYVE9

Sources for ZFYVE9 Gene

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