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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFYVE9 Gene

protein-coding   GIFtS: 59
GCID: GC01P052608

zinc finger, FYVE domain containing 9

(Previous names: MAD, mothers against decapentaplegic homolog (Drosophila)...)
(Previous symbol: MADHIP)
 Explore 21 diseases affiliated with
ZFYVE9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZFYVE9    

Aliases
for ZFYVE9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc Finger, FYVE Domain Containing 91 2     Smad Anchor For Receptor Activation2 3
MADHIP1 2 3     NSP2 3
SARA1 2 3     HSARA1
SMADIP1 2 3     MAD, Mothers Against Decapentaplegic Homolog (Drosophila) Interacting Protein,
Receptor Activation Anchor1
Madh-Interacting Protein2 3     MAD Homolog Interacting Protein2
Mothers Against Decapentaplegic Homolog-Interacting Protein2 3     MAD, Mothers Against Decapentaplegic Homolog Interacting Protein, Receptor
Activation Anchor2
Novel Serine Protease2 3     Mothers Against Decapentaplegic Homolog Interacting Protein2
Receptor Activation Anchor2 3     Zinc Finger FYVE Domain-Containing Protein 92

External Ids:    HGNC: 67751   Entrez Gene: 93722   Ensembl: ENSG000001570777   OMIM: 6037555   UniProtKB: O954053   

Export aliases for ZFYVE9 gene to outside databases

Previous GC identifers: GC01P051978 GC01P052320 GC01P052394 GC01P052380 GC01P050725


Summaries
for ZFYVE9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ZFYVE9:
This gene encodes a double zinc finger (FYVE domain) protein that interacts directly with SMAD2 and SMAD3, and is
involved in Alzheimer's disease. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors
to the nucleus. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein
functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain
the normal localization of this protein but is not involved in mediating interaction with SMADs. The C-terminal domain
of this protein interacts with the TGFB receptor. This protein is a component of the TGFB pathway that brings the SMAD
substrate to the receptor. Three alternatively spliced transcripts encoding distinct isoforms have been found for this
gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ZFYV9_HUMAN, O95405
Function: Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta
receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3
and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor
internalization

Gene Wiki entry for ZFYVE9 (Zinc finger FYVE domain-containing protein 9)


Genomic Views
for ZFYVE9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFYVE9 gene promoter:
         C/EBPbeta   CUTL1   GATA-2   FOXL1   Evi-1   Max   RORalpha1   N-Myc   ZIC2/Zic2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZFYVE9 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFYVE9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFYVE9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

ZFYVE9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFYVE9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P052608:  view genomic region     (about GC identifiers)

Start:
 52,608,046 bp from pter      End:
 52,812,358 bp from pter
Size:
 204,313 bases      Orientation:
 plus strand

Proteins
for ZFYVE9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZFYV9_HUMAN, O95405 (See protein sequence)
Recommended Name: Zinc finger FYVE domain-containing protein 9  
Size: 1425 amino acids; 156403 Da
Subunit: Interacts (via the SBD region) with SMAD2; the interaction recruits SMAD2 to the TGF-beta receptor and is
disrupted by phosphorylation of SMAD2 upon TGF-beta receptor activation. Interacts with SMAD3. Interacts with TGFBR1
and TGFBR2; the interaction recruits SMAD2 to the TGF-beta receptor. Interacts with PML
Subcellular location: Cytoplasm. Early endosome membrane
Sequence caution: Sequence=AAC99462.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAD31694.1; Type=Frameshift; Positions=1243;
2 PDB 3D structures from and Proteopedia for ZFYVE9:
1DEV (3D)        1MK2 (3D)    
Secondary accessions: Q5T0F6 Q5T0F7 Q9UNE1 Q9Y5R7
Alternative splicing: 3 isoforms:  O95405-1   O95405-2   O95405-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ZFYVE9: NX_O95405

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95405

    • ZFYVE9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_004790.2  NP_015562.1  NP_015563.2  

    ENSEMBL proteins: 
     ENSP00000349737   ENSP00000355358   ENSP00000360647   ENSP00000287727  
    Reactome Protein details: O95405
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZFYVE9

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS--
    GO:0005769early endosome NAS12809483
    GO:0031901early endosome membrane TAS--


    ZFYVE9 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZFYVE9

    Protein Domains /
    Families
    for ZFYVE9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZFYVE9 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR024608 SARA_Smad-bd
     IPR000306 Znf_FYVE
     IPR017455 Znf_FYVE-rel
     IPR017165 Znf_FYVE_SARA/endofin
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry O95405

    ProtoNet protein and cluster: O95405

    1 Blocks protein family: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: ZFYV9_HUMAN, O95405
    Domain: The SMAD binding domain (SBD) interacts with the MH2 domains of SMAD2 or SMAD3
    Domain: The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates
    the association with PI3P
    Similarity: Contains 1 FYVE-type zinc finger


    Function
    for ZFYVE9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZFYV9_HUMAN, O95405
    Function: Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta
    receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3
    and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor
    internalization

    miRNA
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    hsa-miR-4328 hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-526b* hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmid: ZFYVE9 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI17693260
    GO:00055451-phosphatidylinositol binding IDA11877415
    GO:0008236serine-type peptidase activity NAS9582421
    GO:0046872metal ion binding IEA--


    ZFYVE9 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ZFYVE9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_TGF-beta receptor signaling
    		Development_TGF-beta receptor signaling1.00
    		Development TGF-beta receptor signaling0.96
    2Cell cycle Regulation of G1/S transition (part 1)
    		Cell cycle Regulation of G1/S transition (part 1)1.00
    		Cell cycle_Regulation of G1/S transition (part 1)0.98
    3TGF-beta receptor signaling activates SMADs
    		TGF-beta receptor signaling activates SMADs1.00
    		Downregulation of TGF-beta receptor signaling0.90
    4TGF Beta Signaling Pathway
    		TGF Beta Signaling Pathway1.00
    5TGF-beta Receptor Signaling Pathway
    		TGF-beta Receptor Signaling Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for ZFYVE9
        Cell cycle Regulation of G1/S transition (part 1)
    Development TGF-beta receptor signaling


    3 GeneGo (Thomson Reuters) Pathways for ZFYVE9
        Cell cycle Regulation of G1/S transition (part 1)
    Cytokine production by Th17 cells in CF (Mouse model)
    Development TGF-beta receptor signaling

    3 BioSystems Pathways for ZFYVE9 
        TGF Beta Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    TGF-beta receptor signaling

    4        Reactome Pathways for ZFYVE9
        Signaling by TGF-beta Receptor Complex
    TGF-beta receptor signaling activates SMADs
    Signal Transduction
    Downregulation of TGF-beta receptor signaling


    2         Kegg Pathways  (Kegg details for ZFYVE9):
        Endocytosis
    TGF-beta signaling pathway


    ZFYVE9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFYVE9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/111 Interacting proteins for ZFYVE9 (O954051, 2, 3 ENSP000002877274) via UniProtKB, MINT, STRING, and/or I2D (see all 111)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157962, 3, ENSP000002621604MINT-62035 MINT-6799207 I2D: score=5 STRING: ENSP00000262160
    SMAD3P840222, 3, ENSP000003329734MINT-61712 MINT-25061 I2D: score=5 STRING: ENSP00000332973
    PPP1CAP621362, 3, ENSP000003260314MINT-62212 MINT-62058 I2D: score=3 STRING: ENSP00000326031
    PMLP295902, 3, ENSP000002680584MINT-6799194 I2D: score=4 STRING: ENSP00000268058
    CTNNB1P352222, 3, ENSP000003444564MINT-62032 I2D: score=3 STRING: ENSP00000344456
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis NAS12809483
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0007183SMAD protein complex assembly IDA9865696
    GO:0007184SMAD protein import into nucleus IMP9865696
    GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway TAS--


    ZFYVE9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZFYVE9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZFYVE9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZFYVE9
    8 Novoseek chemical compound relationships for ZFYVE9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 82.9 111 12795636 (3), 16373075 (3), 16176265 (3), 14871620 (2) (see all 94)
    phosphatidylinositol 3-phosphate 68.2 2 14618335 (1)
    fibrinogen 31.2 1 17674318 (1)
    threonine 16.9 1 18824507 (1)
    proline 13.7 2 11067927 (1), 10477574 (1)
    oligonucleotide 0 1 11327827 (1)
    calcium 0 1 1467310 (1)
    heparin 0 1 14976449 (1)

    Search CenterWatch for drugs/clinical trials and news about ZFYVE9 / ZFYV9 

    Transcripts
    for ZFYVE9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZFYVE9 gene (3 alternative transcripts): 
    NM_004799.2  NM_007323.1  NM_007324.2  

    Unigene Cluster for ZFYVE9:

    Zinc finger, FYVE domain containing 9
    Hs.532345  [show with all ESTs]
    Unigene Representative Sequence: NM_004799
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357206 ENST00000361625(uc001ctn.3) ENST00000371591 ENST00000469134
    ENST00000287727(uc001cto.3 uc001ctp.3)

    miRNA
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    hsa-miR-4328 hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-93 hsa-miR-526b* hsa-miR-130b hsa-miR-301b
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB209125.1 AF104304.1 AF130419.1 AF130420.1 BC032680.1 

    8 DOTS entries:

    DT.433909  DT.95162342  DT.91751079  DT.121299536  DT.435254  DT.91751077  DT.91751078  DT.40288736 

    24/40 AceView cDNA sequences (see all 40):

    BX646047 BM716723 BE048597 AA156466 BM463429 AI632587 BQ340247 BI035332 
    BX096354 BF961624 AV705707 BV195342 AF130420 CB047955 BF671658 NM_007323 
    AI797623 AW614993 AW301671 BG536226 BF961623 NM_004799 BE082533 BF510071 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE9    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:                                            -                                                                                             
    SP2:                                            -     -                                                                                       
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          


    ECgene alternative splicing isoforms for ZFYVE9

    Expression
    for ZFYVE9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFYVE9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTCAGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ZFYVE9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFYVE9

    SOURCE GeneReport for Unigene cluster: Hs.532345

    UniProtKB/Swiss-Prot: ZFYV9_HUMAN, O95405
    Tissue specificity: Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive
    astrocytes

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    In Situ
    Assay Products:     
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    Orthologs
    for ZFYVE9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ZFYVE9 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ZFYVE91 zinc finger, FYVE domain containing 9 77.38(n)
    78.16(a)    		   424639  XM_422473.3  XP_422473.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ZFYVE96
    		 --
    		 73(a)
    		 1 ↔ 1
    		 4(114456677-114504738)
    African clawed frog
    (Xenopus laevis)    		 Amphibia madhip-A2 Smad anchor for receptor activation 80.04(n)    AF104305.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zfyve9a1 zinc finger, FYVE domain containing 9a 70.25(n)
    76.87(a)    		   100005449  XM_001344468.2  XP_001344504.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Sara6
    		 Smad anchor for receptor activation
    		 26(a)
    		 1 → many
    		 2R(17369424-17374618)
    worm
    (Caenorhabditis elegans)    		 Secernentea aka-16
    		 A Kinase Anchor protein family member (aka-1)
    		 18(a)
    		 1 → many
    		 II(7472685-7478914)


    ENSEMBL Gene Tree for ZFYVE9 (if available)
    TreeFam Gene Tree for ZFYVE9 (if available) 

    Paralogs
    for ZFYVE9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFYVE9 gene
    ZFYVE162  
    1 SIMAP similar gene for ZFYVE9 using alignment to 3 protein entries:     ZFYV9_HUMAN (see all proteins):
    ZFYVE16

    ZFYVE9 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for ZFYVE9
    PGOHUM00000258837 PGOHUM00000246994 PGOHUM00000240587 PGOHUM00000242043


    Genomic Variants
    for ZFYVE9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3211 NCBI SNPs in ZFYVE9 are shown (see all 3211)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1875747421,2
    		--52606082(+) ATGTGA/GCAAAG 3 -- us2k10--------
    rs1165981411,2
    		F,--52606336(+) TATGAG/AGCTCT 3 -- us2k12Minor allele frequency- A:0.02NA EA 240
    rs1396910921,2
    		--52606363(+) GTGTTA/TCATAA 3 -- us2k10--------
    rs635510611,2
    		C,F,--52606443(+) GACAGG/AAATAC 3 -- us2k113Minor allele frequency- A:0.02NA WA CSA EA 376
    rs106545361,2
    		C,--52606476(+) CACAT-/ACACACA 3 -- us2k10--------
    rs49265651,2
    		C,F,A,H,--52606488(+) ACACAC/GAGAGA 3 -- us2k1 trp34Minor allele frequency- G:0.38NA CSA 8
    rs1402073071,2
    		C,--52606606(+) TTCTA-/TGGGCC 3 -- us2k10--------
    rs561638141,2
    		C,F,--52606627(+) TCTCCA/TATCTT 3 -- us2k14Minor allele frequency- T:0.17WA CSA 124
    rs1840848541,2
    		--52606663(+) AAAACG/TGAAGT 3 -- us2k10--------
    rs1996342471,2
    		--52606789(+) CTCTG-/TTTAAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZFYVE9 (52608046 - 52812358 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for ZFYVE9
         3 Indels: 68619 24226 58393

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ZFYVE9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZFYVE9 for disorders           About GeneDecksing

    OMIM gene information: 603755    OMIM disorders: --

    20/21 diseases for ZFYVE9 (see all 21):    About MalaCards
    disseminated intravascular coagulation    alzheimer's disease    squamous cell carcinoma of the head and neck    squamous cell carcinoma
    nephropathy    ovarian carcinoma    cervical cancer    cervicitis
    carcinoma    prostate cancer    breast cancer    cervical carcinoma
    influenza    psoriasis    pancreatic cancer    breast carcinoma
    colorectal cancer    prostatitis    ischemia    pancreatitis

    10/14 Novoseek disease relationships for ZFYVE9 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nephropathy iga 33.4 2 16796905 (1), 12386281 (1)
    ovarian carcinoma 20.3 1 10485494 (1)
    diabetic nephropathies 19.4 1 12386281 (1)
    disseminated intravascular coagulation 16.6 1 8745149 (1)
    metastasis 14 4 11751384 (1), 8876194 (1), 12430137 (1), 16049007 (1)
    cervical cancer 7.71 1 14749636 (1)
    cancer 4.55 4 18243805 (1), 16176265 (1), 15713679 (1), 16049007 (1)
    tumors 4.28 10 1727874 (1), 11751384 (1), 15297163 (1), 8876194 (1) (see all 8)
    ovarian cancer 3.66 1 18243805 (1)
    carcinoma squamous cell 0 2 11161383 (1), 16320362 (1)


    Export disorders for ZFYVE9 gene to outside databases

    Publications
    for ZFYVE9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFYVE9 gene, integrated from 9 sources (see all 142):
    (articles sorted by number of sources associating them with ZFYVE9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. (PubMed id 9865696)1, 2, 3, 9 Tsukazaki T.... Wrana J.L. (1998)
    2. Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control. (PubMed id 12154125)1, 2, 9 Qin B.Y.... Lin K. (2002)
    3. Identification of a novel serine protease-like molecule in human brain. (PubMed id 9582421)1, 2, 9 Meckelein B.... Abraham C.R. (1998)
    4. Cytoplasmic PML function in TGF-beta signalling. (PubMed id 15356634)1, 2, 9 Lin H.K....Pandolfi P.P. (2004)
    5. Early endosomal regulation of Smad-dependent signaling in endothelial cells. (PubMed id 11877415)1, 2, 9 Panopoulou E....Fotsis T. (2002)
    6. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Structural basis of Smad2 recognition by the Smad anchor for receptor activation. (PubMed id 10615055)1, 2 Wu G.... Shi Y. (2000)
    9. SARA, a FYVE domain protein, affects Rab5-mediated endocytosis. (PubMed id 12432064)1, 9 Hu Y....Sung C.H. (2002)
    10. Role of SARA (SMAD anchor for receptor activation) in maintenance of epithelial cell phenotype. (PubMed id 19620243)1, 9 Runyan C.E....Schnaper H.W. (2009)

    External Searches for ZFYVE9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZFYVE9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9372 HGNC: 6775 AceView: ZFYVE9 Ensembl:ENSG00000157077 euGenes: HUgn9372
    ECgene: ZFYVE9 Kegg: 9372 H-InvDB: ZFYVE9

    Other Databases showing ZFYVE9 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZFYVE9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFYVE9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZFYVE9 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ZFYVE9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZFYVE9 gene:
    Search GeneIP for patents involving ZFYVE9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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