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ZFYVE28 Gene

protein-coding   GIFtS: 54
GCID: GC04M002271

Zinc Finger, FYVE Domain Containing 28

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, FYVE Domain Containing 281 2     KIAA16433 5
LST22 3 5     LYST22
Zinc Finger FYVE Domain-Containing Protein 282 3     Lateral Signaling Target Protein 2 Homolog2
hLst22 3     

External Ids:    HGNC: 293341   Entrez Gene: 577322   Ensembl: ENSG000001597337   OMIM: 6141765   UniProtKB: Q9HCC93   

Export aliases for ZFYVE28 gene to outside databases

Previous GC identifers: GC04M002233 GC04M002238


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZFYVE28 Gene:
ZFYVE28 (zinc finger, FYVE domain containing 28) is a protein-coding gene. Diseases associated with ZFYVE28 include pulmonary function, and schizophrenia. GO annotations related to this gene include phosphatidylinositol-3-phosphate binding. An important paralog of this gene is ZFYVE9.

UniProtKB/Swiss-Prot: LST2_HUMAN, Q9HCC9
Function: Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR
degradation in endosomes when not monoubiquitinated




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFYVE28 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   CUTL1   E2F-1   E2F   ARP-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFYVE28 promoter sequence
   Search Chromatin IP Primers for ZFYVE28

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFYVE28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

ZFYVE28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFYVE28 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M002271:  view genomic region     (about GC identifiers)

Start:
2,271,309 bp from pter      End:
2,420,390 bp from pter
Size:
149,082 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LST2_HUMAN, Q9HCC9 (See protein sequence)
Recommended Name: Lateral signaling target protein 2 homolog  
Size: 887 amino acids; 96490 Da
Subunit: Interacts with TRIM3
Sequence caution: Sequence=AAH53664.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB13469.1; Type=Erroneous initiation;
Secondary accessions: B2RP83 B3KX50 B7Z1Q7 B7Z2G9 B7Z2M2 B7ZB19 E9PB54 E9PB64 E9PG77 Q7Z6J3
Alternative splicing: 8 isoforms:  Q9HCC9-1   Q9HCC9-2   Q9HCC9-3   Q9HCC9-4   Q9HCC9-5   Q9HCC9-6   Q9HCC9-7   Q9HCC9-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFYVE28: NX_Q9HCC9

Explore proteomics data for ZFYVE28 at MOPED

Post-translational modifications: 

  • Monoubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early
    endosome membranes1
  • Ubiquitination2 at Lys87
  • Modification sites at PhosphoSitePlus

  • See ZFYVE28 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001166127.1  NP_001166128.1  NP_001166129.1  NP_001166130.1  NP_001166131.1  NP_066023.2  

    ENSEMBL proteins: 
     ENSP00000427654   ENSP00000290974   ENSP00000425706   ENSP00000426299   ENSP00000425766  
     ENSP00000422638   ENSP00000423694   ENSP00000427471  

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    Cloud-Clone Corp. Proteins for ZFYVE28

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFYVE: Zinc fingers, FYVE domain containing

    4 InterPro protein domains:
     IPR000306 Znf_FYVE
     IPR013083 Znf_RING/FYVE/PHD
     IPR017455 Znf_FYVE-rel
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q9HCC9

    ProtoNet protein and cluster: Q9HCC9

    1 Blocks protein domain: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: LST2_HUMAN, Q9HCC9
    Domain: The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and
    localization to early endosome membranes when not monoubiquitinated at Lys-87
    Similarity: Belongs to the lst-2 family
    Similarity: Contains 1 FYVE-type zinc finger


    ZFYVE28 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LST2_HUMAN, Q9HCC9
    Function: Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR
    degradation in endosomes when not monoubiquitinated

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19460345
    GO:0032266phosphatidylinositol-3-phosphate binding IDA19460345
    GO:0046872metal ion binding IEA--
         
    ZFYVE28 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZFYVE28:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZFYVE28
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    miRNA
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    miRTarBase miRNAs that target ZFYVE28:
    hsa-mir-335-5p (MIRT018096), hsa-mir-192-5p (MIRT026573)

    Block miRNA regulation of human, mouse, rat ZFYVE28 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFYVE28 (see all 20):
    hsa-miR-4317 hsa-miR-136 hsa-miR-216b hsa-miR-885-5p hsa-miR-500a hsa-miR-548a-3p hsa-miR-3150b-3p hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidZFYVE28 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZFYVE28

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LST2_HUMAN, Q9HCC9: Cytoplasm, cytosol. Early endosome membrane. Note=Localizes to early endosome membrane in
    absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endosome5
    nucleus2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA19460345
    GO:0031901early endosome membrane IDA19460345

    ZFYVE28 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZFYVE28 About    
    See pathways by source

    SuperPathContained pathways About
    1Internalization of ErbB1
    Internalization of ErbB1


    1 BioSystems Pathway for ZFYVE28
        Internalization of ErbB1


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFYVE28
    Interactions:

        Search GeneGlobe Interaction Network for ZFYVE28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZFYVE28 (Q9HCC93 ENSP000002909744) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    EGFP011333, ENSP000002651714I2D: score=1 STRING: ENSP00000265171
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    RAB4AP203383, ENSP000003556514I2D: score=1 STRING: ENSP00000355651
    RAB5AP203393, ENSP000002730474I2D: score=1 STRING: ENSP00000273047
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007175negative regulation of epidermal growth factor-activated receptor activity IMP19460345
    GO:0042059negative regulation of epidermal growth factor receptor signaling pathway IMP19460345

    ZFYVE28 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFYVE28 (LST2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZFYVE28 gene (6 alternative transcripts): 
    NM_001172656.1  NM_001172657.1  NM_001172658.1  NM_001172659.1  NM_001172660.1  NM_020972.2  

    Unigene Cluster for ZFYVE28:

    Zinc finger, FYVE domain containing 28
    Hs.292056  [show with all ESTs]
    Unigene Representative Sequence: AK126692
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508471 ENST00000290974(uc003gew.2 uc011bvk.2 uc003gex.2 uc011bvl.2)
    ENST00000511071 ENST00000515312 ENST00000514248 ENST00000515169(uc003gey.4)
    ENST00000509171(uc003gez.3) ENST00000503000(uc021xkq.1) ENST00000508184
    ENST00000504743 ENST00000505421
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZFYVE28 (see all 20):
    hsa-miR-4317 hsa-miR-136 hsa-miR-216b hsa-miR-885-5p hsa-miR-500a hsa-miR-548a-3p hsa-miR-3150b-3p hsa-miR-3121-3p
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZFYVE28

    Additional mRNA sequence: 

    AB046863.1 AK126692.1 AK293775.1 AK294710.1 AK294874.1 AK316484.1 BC032605.1 BC035793.1 
    BC041866.1 BC053664.1 BC137309.1 BC137310.1 

    6 DOTS entries:

    DT.439461  DT.95345136  DT.101971065  DT.101964122  DT.100681700  DT.91748011 

    Selected AceView cDNA sequences (see all 41):

    AB046863 BQ005210 BM677125 BC041866 CB069515 BM721483 BX089483 BM672438 
    BC053664 AA324976 AK126692 CA307118 AA977137 BU175738 AA961044 BC035793 
    BV195638 BM128958 BM129246 CK819536 BI756141 AW271792 CK819535 AW054793 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE28 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
    SP1:                    -     -     -           -     -           -     -     -                                   -                 -     -                     
    SP2:                                                                                                                                                            
    SP3:                    -     -     -           -     -           -     -     -                                                                                 
    SP4:                                            -     -           -     -     -                                                                                 
    SP5:                    -     -     -     -     -     -           -     -     -                                                                                 

    ExUns: 19b ^ 20a · 20b ^ 21
    SP1:              -         
    SP2:              -         
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ZFYVE28

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFYVE28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTCCGAC
    ZFYVE28 Expression
    About this image

    ZFYVE28 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFYVE28 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.292056
        Custom PCR Arrays for ZFYVE28
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFYVE28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZFYVE28 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfyve281 , 5 zinc finger, FYVE domain containing 281, 5 82.73(n)1
    84.13(a)1
      5 (17.85 cM)5
    2311251  NM_001015039.11  NP_001015039.11 
     341948745 
    chicken
    (Gallus gallus)
    Aves ZFYVE281 zinc finger, FYVE domain containing 28 66.67(n)
    71.33(a)
      422889  XM_420832.4  XP_420832.4 
    lizard
    (Anolis carolinensis)
    Reptilia ZFYVE286
    zinc finger, FYVE domain containing 28
    55(a)
    1 ↔ 1
    2(145473145-145476170)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia zfyve281 zinc finger, FYVE domain containing 28 68.22(n)
    72.62(a)
      779953  NM_001079030.1  NP_001072498.1 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd13742 idibd1374 82.9(n)   338253  57093083 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60516
    --
    32(a)
    1 ↔ 1
    3R(22950481-22976791)
    worm
    (Caenorhabditis elegans)
    Secernentea lst-26
    Protein LST-2 (lst-2) mRNA, complete cds
    41(a)
    1 ↔ 1
    X(4378030-4383366) WBGene00003084
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAB16
    1-phosphatidylinositol-3-phosphate 5-kinase; vacuo...
    5(a)
    1 → many
    VI(184502-191338) YFR019W


    ENSEMBL Gene Tree for ZFYVE28 (if available)
    TreeFam Gene Tree for ZFYVE28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZFYVE28 gene
    ZFYVE92  PIKFYVE2  ZFYVE162  ZFYVE212  
    1 SIMAP similar gene for ZFYVE28 using alignment to 3 protein entries:     LST2_HUMAN (see all proteins):
    MTMR3

    ZFYVE28 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFYVE28 (see all 3839)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413210121,2
    --2270833(+) CATCTC/TCAAAG 3 -- int10--------
    rs1118552061,2
    F--2270898(+) GCGGCT/CGCCCT 3 -- int11Minor allele frequency- C:0.00CSA 1
    rs1380902311,2
    --2270938(+) GCAGCC/TGCTCC 3 -- int10--------
    rs801717481,2
    C,F--2271043(+) CAGAGG/AGCTGA 3 -- int11Minor allele frequency- A:0.18WA 118
    rs21058471,2
    C,F,A--2271113(-) TGCCCC/GTGTGA 3 -- int17Minor allele frequency- G:0.35NA WA EA 366
    rs1162737651,2
    C,F--2271179(+) GAGGGC/ATGGTG 3 -- int11Minor allele frequency- A:0.07WA 118
    rs567568501,2
    C,F--2271209(+) CAGTCG/ATCCCA 3 -- int11Minor allele frequency- A:0.03WA 118
    rs1158088641,2
    F--2271267(+) CAACAC/TCATCG 3 -- int11Minor allele frequency- T:0.01WA 118
    rs1145243821,2
    F--2271320(+) GAGAGC/TGTCTG 3 -- int11Minor allele frequency- T:0.01WA 118
    rs1929534081,2
    --2271427(+) CCCCCC/TGACAG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ZFYVE28 (2271309 - 2420390 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZFYVE28 (see all 42):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2581020CNV Deletion19546169
    dgv118e180CNV Deletion20482838
    esv2726838CNV Deletion23290073
    esv2726844CNV Deletion23290073
    nsv821601CNV Deletion20802225
    esv1496535CNV Deletion17803354
    esv2726842CNV Deletion23290073
    esv2726839CNV Deletion23290073
    esv2726836CNV Deletion23290073
    esv4159CNV Deletion18987735

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614176    OMIM disorders: --

    2 diseases for ZFYVE28:    
    About MalaCards
    pulmonary function    schizophrenia


    ZFYVE28 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZFYVE28
    Human Genome Epidemiology (HuGE) Navigator: ZFYVE28 (1 document)

    Export disorders for ZFYVE28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFYVE28 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ZFYVE28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. (PubMed id 19460345)1, 2 Mosesson Y.... Yarden Y. (Dev. Cell 2009)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms. (PubMed id 23212062)1 Fanous A.H....Levinson D.F. (Am J Psychiatry 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57732 HGNC: 29334 AceView: ZFYVE28 Ensembl:ENSG00000159733 euGenes: HUgn57732
    ECgene: ZFYVE28 H-InvDB: ZFYVE28

    (According to HUGE)
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    HUGE: KIAA1643

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZFYVE28 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFYVE28 gene:
    Search GeneIP for patents involving ZFYVE28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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