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Aliases for ZFYVE28 Gene

Aliases for ZFYVE28 Gene

  • Zinc Finger, FYVE Domain Containing 28 2 3
  • LST2 3 4 6
  • Zinc Finger FYVE Domain-Containing Protein 28 3 4
  • KIAA1643 4 6
  • HLst2 3 4
  • Lateral Signaling Target Protein 2 Homolog 3
  • LYST2 3

External Ids for ZFYVE28 Gene

Previous GeneCards Identifiers for ZFYVE28 Gene

  • GC04M002233
  • GC04M002238

Summaries for ZFYVE28 Gene

GeneCards Summary for ZFYVE28 Gene

ZFYVE28 (Zinc Finger, FYVE Domain Containing 28) is a Protein Coding gene. Among its related pathways are Internalization of ErbB1. GO annotations related to this gene include phosphatidylinositol-3-phosphate binding. An important paralog of this gene is ZFYVE16.

UniProtKB/Swiss-Prot for ZFYVE28 Gene

  • Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFYVE28 Gene

Genomics for ZFYVE28 Gene

Regulatory Elements for ZFYVE28 Gene

Genomic Location for ZFYVE28 Gene

2,269,582 bp from pter
2,418,674 bp from pter
149,093 bases
Minus strand

Genomic View for ZFYVE28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFYVE28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFYVE28 Gene

Proteins for ZFYVE28 Gene

  • Protein details for ZFYVE28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lateral signaling target protein 2 homolog
    Protein Accession:
    Secondary Accessions:
    • B2RP83
    • B3KX50
    • B7Z1Q7
    • B7Z2G9
    • B7Z2M2
    • B7ZB19
    • E9PB54
    • E9PB64
    • E9PG77
    • Q7Z6J3

    Protein attributes for ZFYVE28 Gene

    887 amino acids
    Molecular mass:
    96490 Da
    Quaternary structure:
    • Interacts with TRIM3.
    • Sequence=AAH53664.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB13469.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFYVE28 Gene

neXtProt entry for ZFYVE28 Gene

Proteomics data for ZFYVE28 Gene at MOPED

Post-translational modifications for ZFYVE28 Gene

  • Monoubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes
  • Ubiquitination at Lys87
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZFYVE28 Gene

Domains for ZFYVE28 Gene

Gene Families for ZFYVE28 Gene

  • ZFYVE :Zinc fingers, FYVE domain containing

Protein Domains for ZFYVE28 Gene

Suggested Antigen Peptide Sequences for ZFYVE28 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9HCC9
  • The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not monoubiquitinated at Lys-87.
  • Belongs to the lst-2 family.
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with ZFYVE28: view

Function for ZFYVE28 Gene

Molecular function for ZFYVE28 Gene

UniProtKB/Swiss-Prot Function: Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated.

Gene Ontology (GO) - Molecular Function for ZFYVE28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19460345
GO:0032266 phosphatidylinositol-3-phosphate binding IDA 19460345
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFYVE28: view

Phenotypes for ZFYVE28 Gene

GenomeRNAi human phenotypes for ZFYVE28:
genes like me logo Genes that share phenotypes with ZFYVE28: view

Animal Model Products

CRISPR Products

miRNA for ZFYVE28 Gene

miRTarBase miRNAs that target ZFYVE28

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFYVE28

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFYVE28 Gene

Localization for ZFYVE28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFYVE28 Gene

Cytoplasm, cytosol. Early endosome membrane. Note=Localizes to early endosome membrane in absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated.

Subcellular locations from

Jensen Localization Image for ZFYVE28 Gene COMPARTMENTS Subcellular localization image for ZFYVE28 gene
Compartment Confidence
cytosol 5
endosome 5
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZFYVE28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 19460345
GO:0031901 early endosome membrane IDA 19460345
genes like me logo Genes that share ontologies with ZFYVE28: view

Pathways for ZFYVE28 Gene

SuperPathways for ZFYVE28 Gene

Superpath Contained pathways
1 Internalization of ErbB1
genes like me logo Genes that share pathways with ZFYVE28: view

Pathways by source for ZFYVE28 Gene

1 BioSystems pathway for ZFYVE28 Gene

Gene Ontology (GO) - Biological Process for ZFYVE28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity IMP 19460345
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IMP 19460345
genes like me logo Genes that share ontologies with ZFYVE28: view

Transcripts for ZFYVE28 Gene

Unigene Clusters for ZFYVE28 Gene

Zinc finger, FYVE domain containing 28:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFYVE28

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZFYVE28

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE28 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - -

ExUns: 19b ^ 20a · 20b ^ 21
SP1: -
SP2: -

Relevant External Links for ZFYVE28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFYVE28 Gene

mRNA expression in normal human tissues for ZFYVE28 Gene

mRNA differential expression in normal tissues according to GTEx for ZFYVE28 Gene

This gene is overexpressed in Brain - Cerebellum (6.7) and Brain - Cerebellar Hemisphere (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZFYVE28 Gene

SOURCE GeneReport for Unigene cluster for ZFYVE28 Gene Hs.292056

genes like me logo Genes that share expressions with ZFYVE28: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZFYVE28 Gene

Orthologs for ZFYVE28 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFYVE28 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFYVE28 35
  • 97.66 (n)
  • 97.37 (a)
ZFYVE28 36
  • 99 (a)
(Bos Taurus)
Mammalia ZFYVE28 35
  • 82.66 (n)
  • 80.69 (a)
ZFYVE28 36
  • 79 (a)
(Canis familiaris)
Mammalia ZFYVE28 35
  • 81.25 (n)
  • 81.13 (a)
ZFYVE28 36
  • 76 (a)
(Mus musculus)
Mammalia Zfyve28 35
  • 82.73 (n)
  • 84.13 (a)
Zfyve28 16
Zfyve28 36
  • 82 (a)
(Monodelphis domestica)
Mammalia ZFYVE28 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia ZFYVE28 36
  • 75 (a)
(Rattus norvegicus)
Mammalia Zfyve28 35
  • 82.24 (n)
  • 83.11 (a)
(Gallus gallus)
Aves ZFYVE28 35
  • 66.67 (n)
  • 71.33 (a)
ZFYVE28 36
  • 66 (a)
(Anolis carolinensis)
Reptilia ZFYVE28 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zfyve28 35
  • 68.22 (n)
  • 72.62 (a)
(Danio rerio)
Actinopterygii idibd1374 35
zfyve28 35
  • 66.3 (n)
  • 69.29 (a)
zfyve28 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6051 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea lst-2 36
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAB1 36
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4065 36
  • 10 (a)
Species with no ortholog for ZFYVE28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFYVE28 Gene

Gene Tree for ZFYVE28 (if available)
Gene Tree for ZFYVE28 (if available)

Paralogs for ZFYVE28 Gene

Paralogs for ZFYVE28 Gene

Selected SIMAP similar genes for ZFYVE28 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZFYVE28: view

Variants for ZFYVE28 Gene

Sequence variations from dbSNP and Humsavar for ZFYVE28 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs586998 -- 2,333,223(-) agggg(A/G)ggtca intron-variant
rs598641 -- 2,304,007(-) TGGGC(A/G)CAGTG intron-variant
rs599639 -- 2,335,877(-) TGAGC(A/G)CACTG intron-variant
rs599642 -- 2,335,876(-) GAGCG(A/C)ACTGC intron-variant
rs608678 -- 2,317,619(-) ATGCC(A/G)TGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFYVE28 Gene

Variant ID Type Subtype PubMed ID
esv2726835 CNV Deletion 23290073
nsv829838 CNV Loss 17160897
nsv878423 CNV Loss 21882294
nsv878424 CNV Loss 21882294
dgv5421n71 CNV Loss 21882294
nsv527189 CNV Loss 19592680
dgv312n21 CNV Loss 19592680
nsv508990 CNV Insertion 20534489
nsv4200 CNV Insertion 18451855
nsv878430 CNV Loss 21882294
nsv524965 CNV Loss 19592680
dgv5423n71 CNV Loss 21882294
esv2490640 CNV Insertion 19546169
esv2726836 CNV Deletion 23290073
esv2726837 CNV Deletion 23290073
esv2573577 CNV Insertion 19546169
esv2669640 CNV Deletion 23128226
nsv878433 CNV Loss 21882294
nsv518472 CNV Loss 19592680
nsv878434 CNV Loss 21882294
esv2726838 CNV Deletion 23290073
dgv5424n71 CNV Loss 21882294
esv2581020 CNV Deletion 19546169
esv2058080 CNV Deletion 18987734
nsv513117 CNV Loss 21212237
esv2726839 CNV Deletion 23290073
esv6725 CNV Loss 19470904
esv27184 CNV Loss 19812545
nsv821601 CNV Deletion 20802225
esv4159 CNV Deletion 18987735
dgv118e180 CNV Deletion 20482838
dgv852e201 CNV Deletion 23290073
esv2726842 CNV Deletion 23290073
esv1676935 CNV Deletion 17803354
esv2726844 CNV Deletion 23290073
nsv291825 CNV Loss 16902084
esv2726845 CNV Deletion 23290073
esv1496535 CNV Deletion 17803354
dgv5425n71 CNV Loss 21882294
esv33985 CNV Gain+Loss 17666407
esv32578 CNV Loss 17666407
esv25676 CNV Loss 19812545

Relevant External Links for ZFYVE28 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFYVE28 Gene

Disorders for ZFYVE28 Gene

Relevant External Links for ZFYVE28

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ZFYVE28: view

No data available for UniProtKB/Swiss-Prot for ZFYVE28 Gene

Publications for ZFYVE28 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. (PMID: 19460345) Mosesson Y. … Yarden Y. (Dev. Cell 2009) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for ZFYVE28 Gene

Sources for ZFYVE28 Gene

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