Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFYVE28 Gene

protein-coding   GIFtS: 51
GCID: GC04M002271

Zinc Finger, FYVE Domain Containing 28

  Search for ZFYVE28
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, FYVE Domain Containing 281 2     LYST22
Zinc Finger FYVE Domain-Containing Protein 282 3     Lateral Signaling Target Protein 2 Homolog2
LST22 3     KIAA16433
hLst22 3     

External Ids:    HGNC: 293341   Entrez Gene: 577322   Ensembl: ENSG000001597337   OMIM: 6141765   UniProtKB: Q9HCC93   

Export aliases for ZFYVE28 gene to outside databases

Previous GC identifers: GC04M002233 GC04M002238


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZFYVE28 Gene: 
ZFYVE28 (zinc finger, FYVE domain containing 28) is a protein-coding gene. GO annotations related to this gene include metal ion binding and phosphatidylinositol-3-phosphate binding. An important paralog of this gene is ZFYVE9.

UniProtKB/Swiss-Prot: LST2_HUMAN, Q9HCC9
Function: Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR
degradation in endosomes when not monoubiquitinated




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006051.18  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFYVE28 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   CUTL1   E2F-1   E2F   ARP-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFYVE28 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFYVE28

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFYVE28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

ZFYVE28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFYVE28 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M002271:  view genomic region     (about GC identifiers)

Start:
2,271,309 bp from pter      End:
2,420,390 bp from pter
Size:
149,082 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LST2_HUMAN, Q9HCC9 (See protein sequence)
Recommended Name: Lateral signaling target protein 2 homolog  
Size: 887 amino acids; 96490 Da
Subunit: Interacts with TRIM3
Subcellular location: Cytoplasm, cytosol. Early endosome membrane. Note=Localizes to early endosome membrane in
absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated
Sequence caution: Sequence=AAH53664.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB13469.1; Type=Erroneous initiation;
Secondary accessions: B2RP83 B3KX50 B7Z1Q7 B7Z2G9 B7Z2M2 B7ZB19 E9PB54 E9PB64 E9PG77 Q7Z6J3
Alternative splicing: 8 isoforms:  Q9HCC9-1   Q9HCC9-2   Q9HCC9-3   Q9HCC9-4   Q9HCC9-5   Q9HCC9-6   Q9HCC9-7   Q9HCC9-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFYVE28: NX_Q9HCC9

Explore proteomics data for ZFYVE28 at MOPED 

Post-translational modifications:

  • UniProtKB: Monoubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early
    endosome membranes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCC9

  • ZFYVE28 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFYVE28 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001166127.1  NP_001166128.1  NP_001166129.1  NP_001166130.1  NP_001166131.1  NP_066023.2  

    ENSEMBL proteins: 
     ENSP00000427654   ENSP00000290974   ENSP00000425706   ENSP00000426299   ENSP00000425766  
     ENSP00000422638   ENSP00000423694   ENSP00000427471  

    Human Recombinant Protein Products for ZFYVE28: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ZFYVE28
    GenScript Custom Purified and Recombinant Proteins Services for ZFYVE28
    Novus Biologicals ZFYVE28 Protein
    Novus Biologicals ZFYVE28 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZFYVE28 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA19460345
    GO:0031901early endosome membrane IDA19460345

    ZFYVE28 for ontologies           About GeneDecksing



    ZFYVE28 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZFYVE28
    GenScript Custom Superior Antibodies Services for ZFYVE28
    Novus Biologicals ZFYVE28 Antibodies
    Search for Antibodies for ZFYVE28 at Abcam
    Cloud-Clone Corp. Antibodies for ZFYVE28 
    ThermoFisher Antibodies for ZFYVE28
    LSBio Antibodies in human, mouse, rat for ZFYVE28 

    Assay Products for ZFYVE28: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZFYVE28
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZFYVE28
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZFYVE28 
    Cloud-Clone Corp. CLIAs for ZFYVE28


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZFYVE: Zinc fingers, FYVE domain containing

    4 InterPro protein domains:
     IPR000306 Znf_FYVE
     IPR017455 Znf_FYVE-rel
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q9HCC9

    ProtoNet protein and cluster: Q9HCC9

    1 Blocks protein domain: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: LST2_HUMAN, Q9HCC9
    Domain: The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and
    localization to early endosome membranes when not monoubiquitinated at Lys-87
    Similarity: Belongs to the lst-2 family
    Similarity: Contains 1 FYVE-type zinc finger


    ZFYVE28 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LST2_HUMAN, Q9HCC9
    Function: Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR
    degradation in endosomes when not monoubiquitinated

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19460345
    GO:0032266phosphatidylinositol-3-phosphate binding IDA19460345
    GO:0046872metal ion binding IEA--
         
    ZFYVE28 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZFYVE28:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFYVE28 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZFYVE28

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZFYVE28 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZFYVE28 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFYVE28
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFYVE28 (see all 20):
    hsa-miR-4317 hsa-miR-136 hsa-miR-216b hsa-miR-885-5p hsa-miR-500a hsa-miR-548a-3p hsa-miR-3150b-3p hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidZFYVE28 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZFYVE28
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFYVE28

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZFYVE28
    Sirion Biotech Customized adenovirus for overexpression of ZFYVE28

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ZFYVE28 (see all 23)
    OriGene ORF clones in mouse, rat for ZFYVE28
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): ZFYVE28 (NM_020972)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFYVE28
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFYVE28
    Sirion Biotech Customized lentivirus for stable overexpression of ZFYVE28 
                         Customized lentivirus expression plasmids for stable overexpression of ZFYVE28 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZFYVE28
    Search LifeMap BioReagents cell lines for ZFYVE28
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFYVE28


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZFYVE28 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Internalization of ErbB1
    Internalization of ErbB1


    1 BioSystems Pathway for ZFYVE28
        Internalization of ErbB1


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFYVE28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for ZFYVE28 (Q9HCC93 ENSP000002909744) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    EGFP011333, ENSP000002651714I2D: score=1 STRING: ENSP00000265171
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    RAB4AP203383, ENSP000003556514I2D: score=1 STRING: ENSP00000355651
    RAB5AP203393, ENSP000002730474I2D: score=1 STRING: ENSP00000273047
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007175negative regulation of epidermal growth factor-activated receptor activity IMP19460345
    GO:0042059negative regulation of epidermal growth factor receptor signaling pathway IMP19460345

    ZFYVE28 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFYVE28 (LST2)

    Search CenterWatch for drugs/clinical trials and news about ZFYVE28 / LST2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFYVE28 gene (6 alternative transcripts): 
    NM_001172656.1  NM_001172657.1  NM_001172658.1  NM_001172659.1  NM_001172660.1  NM_020972.2  

    Unigene Cluster for ZFYVE28:

    Zinc finger, FYVE domain containing 28
    Hs.292056  [show with all ESTs]
    Unigene Representative Sequence: AK126692
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508471 ENST00000290974(uc003gew.2 uc011bvk.2 uc003gex.2 uc011bvl.2)
    ENST00000511071 ENST00000515312 ENST00000514248 ENST00000515169(uc003gey.4)
    ENST00000509171(uc003gez.3) ENST00000503000(uc021xkq.1) ENST00000508184
    ENST00000504743 ENST00000505421
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFYVE28
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFYVE28 (see all 20):
    hsa-miR-4317 hsa-miR-136 hsa-miR-216b hsa-miR-885-5p hsa-miR-500a hsa-miR-548a-3p hsa-miR-3150b-3p hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidZFYVE28 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZFYVE28
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFYVE28
    Clone
    Products:
         
    OriGene clones in human, mouse for ZFYVE28 (see all 23)
    OriGene ORF clones in mouse, rat for ZFYVE28
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): ZFYVE28 (NM_020972)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFYVE28
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFYVE28
    Sirion Biotech Customized lentivirus for stable overexpression of ZFYVE28 
                         Customized lentivirus expression plasmids for stable overexpression of ZFYVE28 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZFYVE28
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFYVE28
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFYVE28
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFYVE28

    Additional mRNA sequence: 

    AB046863.1 AK126692.1 AK293775.1 AK294710.1 AK294874.1 AK316484.1 BC032605.1 BC035793.1 
    BC041866.1 BC053664.1 BC137309.1 BC137310.1 

    6 DOTS entries:

    DT.439461  DT.95345136  DT.101971065  DT.101964122  DT.100681700  DT.91748011 

    24/41 AceView cDNA sequences (see all 41):

    BM721483 BX089483 BQ005210 BM677125 CB069515 BM672438 AB046863 BC053664 
    BC041866 AW271792 BM128958 AA977137 CA433241 BE327635 CK819535 CA307118 
    BM129246 AA324976 BC035793 BI756141 AK126692 AA961044 BC032605 AW130023 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE28 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
    SP1:                    -     -     -           -     -           -     -     -                                   -                 -     -                     
    SP2:                                                                                                                                                            
    SP3:                    -     -     -           -     -           -     -     -                                                                                 
    SP4:                                            -     -           -     -     -                                                                                 
    SP5:                    -     -     -     -     -     -           -     -     -                                                                                 

    ExUns: 19b ^ 20a · 20b ^ 21
    SP1:              -         
    SP2:              -         
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ZFYVE28

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFYVE28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTCCGAC
    ZFYVE28 Expression
    About this image


    See ZFYVE28 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFYVE28

    SOURCE GeneReport for Unigene cluster: Hs.292056
        SABiosciences Custom PCR Arrays for ZFYVE28
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZFYVE28
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFYVE28
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFYVE28
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFYVE28
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFYVE28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZFYVE28 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfyve281 , 5 zinc finger, FYVE domain containing 281, 5 82.77(n)1
    84.24(a)1
      5 (17.85 cM)5
    2311251  NM_001015039.11  NP_001015039.11 
     341948745 
    chicken
    (Gallus gallus)
    Aves ZFYVE281 zinc finger, FYVE domain containing 28 66.63(n)
    71.31(a)
      422889  XM_420832.3  XP_420832.3 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd13742 idibd1374 82.9(n)   338253  57093083 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60516
    --
    22(a)
    1 ↔ 1
    3R(22950481-22976791)
    worm
    (Caenorhabditis elegans)
    Secernentea lst-26
    Lateral signaling target protein 2
    31(a)
    1 ↔ 1
    X(4378030-4383366)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAB16
    1-phosphatidylinositol-3-phosphate 5-kinase; vacuo...
    2(a)
    1 → many
    VI(184502-191338)


    ENSEMBL Gene Tree for ZFYVE28 (if available)
    TreeFam Gene Tree for ZFYVE28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFYVE28 gene
    ZFYVE92  PIKFYVE2  ZFYVE162  ZFYVE212  
    1 SIMAP similar gene for ZFYVE28 using alignment to 3 protein entries:     LST2_HUMAN (see all proteins):
    MTMR3

    ZFYVE28 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3839 SNPs in ZFYVE28 are shown (see all 3839)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413210121,2
    --2270833(+) CATCTC/TCAAAG 3 -- int10--------
    rs1118552061,2
    F--2270898(+) GCGGCT/CGCCCT 3 -- int11Minor allele frequency- C:0.00CSA 1
    rs1380902311,2
    --2270938(+) GCAGCC/TGCTCC 3 -- int10--------
    rs801717481,2
    C,F--2271043(+) CAGAGG/AGCTGA 3 -- int11Minor allele frequency- A:0.18WA 118
    rs21058471,2
    C,F,A--2271113(-) TGCCCC/GTGTGA 3 -- int17Minor allele frequency- G:0.35NA WA EA 366
    rs1162737651,2
    C,F--2271179(+) GAGGGC/ATGGTG 3 -- int11Minor allele frequency- A:0.07WA 118
    rs567568501,2
    C,F--2271209(+) CAGTCG/ATCCCA 3 -- int11Minor allele frequency- A:0.03WA 118
    rs1158088641,2
    F--2271267(+) CAACAC/TCATCG 3 -- int11Minor allele frequency- T:0.01WA 118
    rs1145243821,2
    F--2271320(+) GAGAGC/TGTCTG 3 -- int11Minor allele frequency- T:0.01WA 118
    rs1929534081,2
    --2271427(+) CCCCCC/TGACAG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ZFYVE28 (2271309 - 2420390 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/42 variations for ZFYVE28 (see all 42):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2581020CNV Deletion19546169
    dgv118e180CNV Deletion20482838
    esv2726838CNV Deletion23290073
    esv2726844CNV Deletion23290073
    nsv821601CNV Deletion20802225
    esv1496535CNV Deletion17803354
    esv2726842CNV Deletion23290073
    esv2726839CNV Deletion23290073
    esv2726836CNV Deletion23290073
    esv4159CNV Deletion18987735

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZFYVE28
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFYVE28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZFYVE28 for disorders           About MalaCards
    OMIM gene information: 614176    OMIM disorders: --


    ZFYVE28 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZFYVE28
    Human Genome Epidemiology (HuGE) Navigator: ZFYVE28 (1 document)

    Export disorders for ZFYVE28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFYVE28 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with ZFYVE28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. (PubMed id 19460345)1, 2 Mosesson Y.... Yarden Y. (2009)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    5. Genome-wide association study of clinical dimensions o f schizophrenia: polygenic effect on disorganized symptoms. (PubMed id 23212062)1 Fanous A.H....Levinson D.F. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57732 HGNC: 29334 AceView: ZFYVE28 Ensembl:ENSG00000159733 euGenes: HUgn57732
    ECgene: ZFYVE28 H-InvDB: ZFYVE28

    (According to HUGE)
    About This Section
    HUGE: KIAA1643

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFYVE28 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFYVE28 gene:
    Search GeneIP for patents involving ZFYVE28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZFYVE28  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZFYVE28  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZFYVE28   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZFYVE28   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZFYVE28   OriGene Custom Protein Services for ZFYVE28  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZFYVE28
     QIAGEN SeqTarget long-range PCR primers for resequencing ZFYVE28
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFYVE28
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFYVE28
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFYVE28
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFYVE28
     GenScript Custom Purified and Recombinant Proteins Services for ZFYVE28 GenScript cDNA clones with any tag delivered in your preferred vector for ZFYVE28
     GenScript Custom Assay Services for ZFYVE28 GenScript Custom Superior Antibodies Services for ZFYVE28
     GenScript Custom overexpressing Cell Line Services for ZFYVE28 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ZFYVE28 promoter
     Search Chromatin IP Primers for ZFYVE28
     RT2 qPCR Primer Assay in human, mouse, rat ZFYVE28
     Search GNC Networks for ZFYVE28
     SABiosciences Custom PCR Arrays for ZFYVE28
     Search Tocris compounds for ZFYVE28 (LST2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ZFYVE28 antibodies
     ZFYVE28 proteins
     ZFYVE28 lysates
     Search for Antibodies for ZFYVE28 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ZFYVE28
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ZFYVE28
     Antibodies for ZFYVE28
     ELISAs for ZFYVE28
     CLIAs for ZFYVE28
     Search LifeMap BioReagents cell lines for ZFYVE28
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFYVE28
     SwitchGear 3'UTR luciferase reporter plasmids for ZFYVE28
     SwitchGear Promoter luciferase reporter plasmids for ZFYVE28
     ThermoFisher Antibodies for ZFYVE28
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFYVE28
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFYVE28
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZFYVE28
    Customized:
     lentivirus for stable overexpression of ZFYVE28
     lentivirus expression plasmids for stable overexpression of ZFYVE28
     adenovirus for overexpression of ZFYVE28
     LSBio Antibodies in human, mouse, rat for ZFYVE28
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZFYVE28 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4