Aliases for ZFYVE27 Gene
External Ids for ZFYVE27 Gene
Previous GeneCards Identifiers for ZFYVE27 Gene
This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]
GeneCards Summary for ZFYVE27 Gene
ZFYVE27 (Zinc Finger, FYVE Domain Containing 27) is a Protein Coding gene. Diseases associated with ZFYVE27 include spastic paraplegia 33 and spastic paraplegia 33, autosomal dominant. Among its related pathways are Endocytosis.
UniProtKB/Swiss-Prot for ZFYVE27 Gene
Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation.