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ZFYVE27 Gene

protein-coding   GIFtS: 49
GCID: GC10P099486

Zinc Finger, FYVE Domain Containing 27

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, FYVE Domain Containing 271 2
protrudin1 2
SPG332 5
PROTRUDIN2
Zinc Finger FYVE Domain-Containing Protein 273

External Ids:    HGNC: 265591   Entrez Gene: 1188132   Ensembl: ENSG000001552567   OMIM: 6102435   UniProtKB: Q5T4F43   

Export aliases for ZFYVE27 gene to outside databases

Previous GC identifers: GC10P099162 GC10P093122


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZFYVE27 Gene:
This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE
finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been
reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which
may simply represent a polymorphism, is unclear. (provided by RefSeq, Mar 2010)

GeneCards Summary for ZFYVE27 Gene:
ZFYVE27 (zinc finger, FYVE domain containing 27) is a protein-coding gene. Diseases associated with ZFYVE27 include spastic paraplegia 33, and spastic paraplegia 33, autosomal dominant.

UniProtKB/Swiss-Prot: ZFY27_HUMAN, Q5T4F4
Function: Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming
neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell
projections formation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZFYVE27 gene promoter:
         HFH-3   Elk-1   RFX1   RelA   AP-4   NF-kappaB   HEN1   RORalpha1   MZF-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFYVE27 promoter sequence
   Search Chromatin IP Primers for ZFYVE27

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFYVE27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.2   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q24.2

ZFYVE27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFYVE27 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P099486:  view genomic region     (about GC identifiers)

Start:
99,496,878 bp from pter      End:
99,520,664 bp from pter
Size:
23,787 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZFY27_HUMAN, Q5T4F4 (See protein sequence)
Recommended Name: Protrudin  
Size: 411 amino acids; 45843 Da
Subunit: Interacts with SPAST. Interacts with RAB11A (GDP-bound form); regulates RAB11A. Interacts with FKBP8; may
negatively regulate ZFYVE27 phosphorylation. Interacts with VAPA (via MSP domain); may regulate ZFYVE27 retention
in the endoplasmic reticulum and its function in cell projections formation. Interacts with VAPB (via MSP domain)
Sequence caution: Sequence=CAD38913.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for ZFYVE27:
1X4U (3D)    
Secondary accessions: B7Z3S0 B7Z404 B7Z626 G8JLC3 G8JLF0 J3KP98 Q5T4F1 Q5T4F2 Q5T4F3 Q8N1K0
Q8N6D6 Q8NCA0 Q8NDE4 Q96M08
Alternative splicing: 8 isoforms:  Q5T4F4-1   Q5T4F4-2   Q5T4F4-3   Q5T4F4-4   Q5T4F4-5   Q5T4F4-6   Q5T4F4-7   Q5T4F4-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFYVE27: NX_Q5T4F4

Explore proteomics data for ZFYVE27 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation is induced by NGF through the MAPK/ERK pathway and modulates interaction with
    RAB11A1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZFYVE27 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001002261.1  NP_001002262.1  NP_001167590.1  NP_001167591.1  NP_001167592.1  NP_001167593.1  NP_653189.3  

    ENSEMBL proteins: 
     ENSP00000377282   ENSP00000353069   ENSP00000409594   ENSP00000337993   ENSP00000350148  
     ENSP00000359646   ENSP00000348593   ENSP00000401580   ENSP00000359642  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFYVE: Zinc fingers, FYVE domain containing

    4 InterPro protein domains:
     IPR000306 Znf_FYVE
     IPR013083 Znf_RING/FYVE/PHD
     IPR017455 Znf_FYVE-rel
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q5T4F4

    ProtoNet protein and cluster: Q5T4F4

    1 Blocks protein domain: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: ZFY27_HUMAN, Q5T4F4
    Similarity: Contains 1 FYVE-type zinc finger


    ZFYVE27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFY27_HUMAN, Q5T4F4
    Function: Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming
    neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell
    projections formation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17082457
    GO:0046872metal ion binding IEA--
         
    ZFYVE27 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZFYVE27
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    miRNA
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    miRTarBase miRNAs that target ZFYVE27:
    hsa-mir-193b-3p (MIRT041333), hsa-mir-615-3p (MIRT040082), hsa-mir-423-3p (MIRT042621)

    Block miRNA regulation of human, mouse, rat ZFYVE27 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFYVE27 (see all 11):
    hsa-miR-4290 hsa-miR-3175 hsa-miR-3914 hsa-miR-1205 hsa-miR-3179 hsa-miR-199a-5p hsa-miR-873 hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidZFYVE27 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZFYVE27

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    GenScript: all cDNA clones in your preferred vector (see all 7): ZFYVE27 (NM_001002261)
    Sino Biological Human cDNA Clone for ZFYVE27
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFYVE27


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZFY27_HUMAN, Q5T4F4: Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane;
    Multi-pass membrane protein. Cell projection, growth cone membrane; Multi-pass membrane protein. Cell membrane;
    Multi-pass membrane protein. Note=Localizes at both dendrites and axons (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    plasma membrane5
    cytosol3
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IDA19289470
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0030424axon ISS--

    ZFYVE27 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFYVE27
    Interactions:

        Search GeneGlobe Interaction Network for ZFYVE27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ZFYVE27 (Q5T4F41 ENSP000003485934) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VAPAQ9P0L01, ENSP000003456564EBI-3892947,EBI-1059156 STRING: ENSP00000345656
    VAPBO952921, ENSP000004171754EBI-3892947,EBI-1188298 STRING: ENSP00000417175
    FKBP8Q143181, ENSP000002223084EBI-3892947,EBI-724839 STRING: ENSP00000222308
    RAB11AP624911, ENSP000002618904EBI-3892947,EBI-745098 STRING: ENSP00000261890
    CCT3ENSP000003572444STRING: ENSP00000357244
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008219cell death IEA--
    GO:0031175neuron projection development IDA17082457
    GO:0048011neurotrophin TRK receptor signaling pathway ISS--
    GO:0072659protein localization to plasma membrane ISS--

    ZFYVE27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFYVE27 (ZFY27)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZFYVE27 gene (7 alternative transcripts): 
    NM_001002261.3  NM_001002262.3  NM_001174119.1  NM_001174120.1  NM_001174121.1  NM_001174122.1  NM_144588.6  

    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393677(uc001kol.2 uc001kom.2 uc010qpc.2) ENST00000359980
    ENST00000462887 ENST00000423811 ENST00000481956 ENST00000477521 ENST00000473237
    ENST00000337540(uc010qpd.2) ENST00000357540(uc001koq.3) ENST00000370613(uc010qpa.2)
    ENST00000356257(uc021pwq.1) ENST00000453958 ENST00000370610(uc010qpb.2)


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    Selected qRT-PCR Assays for microRNAs that regulate ZFYVE27 (see all 11):
    hsa-miR-4290 hsa-miR-3175 hsa-miR-3914 hsa-miR-1205 hsa-miR-3179 hsa-miR-199a-5p hsa-miR-873 hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidZFYVE27 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 7): ZFYVE27 (NM_001002261)
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      QuantiTect SYBR Green Assays in human, mouse, rat ZFYVE27
      QuantiFast Probe-based Assays in human, mouse, rat ZFYVE27

    Selected AceView cDNA sequences (see all 215):

    AI571631 BM676588 BU633861 BX353891 AI919459 BX505988 AA814392 BM710362 
    BU838354 AW771070 AA716464 AI670017 AW449006 BM970604 AW630379 F27417 
    CB150532 AI858941 CB144283 BE043014 CB148189 AI287721 BF058091 BF063694 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE27 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^
    SP1:                                            -           -                                                           -           -           -     -         
    SP2:                                      -     -           -                                                                       -                 -     -   
    SP3:                                            -     -     -     -     -                                               -           -           -     -         
    SP4:                                            -           -                                                                                                   
    SP5:                                                                                                                                -           -     -         

    ExUns: 14 ^ 15a · 15b · 15c ^ 16 ^ 17
    SP1:                                    
    SP2:  -     -     -     -               
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for ZFYVE27

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFYVE27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGGGCTGA
    ZFYVE27 Expression
    About this image

    ZFYVE27 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFYVE27 Protein Expression
        Custom PCR Arrays for ZFYVE27
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFYVE27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZFYVE27 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfyve271 , 5 zinc finger, FYVE domain containing 271, 5 85.77(n)1
    88.29(a)1
      19 (35.87 cM)5
    3197401  NM_177319.31  NP_796293.21 
     421639515 
    chicken
    (Gallus gallus)
    Aves ZFYVE271 zinc finger, FYVE domain containing 27 70.32(n)
    70.07(a)
      423839  NM_001039304.1  NP_001034393.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZFYVE276
    zinc finger, FYVE domain containing 27
    60(a)
    1 ↔ 1
    3(39126779-39157069)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia zfyve271 zinc finger, FYVE domain containing 27 65.4(n)
    66.33(a)
      100144696  NM_001123454.1  NP_001116926.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zfyve271 zinc finger, FYVE domain containing 27 59.35(n)
    52.2(a)
      561659  NM_001077291.2  NP_001070759.2 


    ENSEMBL Gene Tree for ZFYVE27 (if available)
    TreeFam Gene Tree for ZFYVE27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFYVE27 (see all 675)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs350773841,2,,4
    C,FSpastic paraplegia 33, autosomal dominant (SPG33)4 unknown199870829(-) CTGTGC/ACCAGA 14 /G /V mis111Minor allele frequency- A:0.03NA NS EA WA EU 6613
    rs2012294201,2
    --93121034(+) CATGT-/AG    
       GAAAG
    AGGGG
    6 -- us2k10--------
    rs665272701,2
    C--93130159(+) CTAGC-/TGTT  
            
    TGTTT
    7 -- int10--------
    rs3748081381,2
    C--93130175(+) TTCTG-/TTCT  
            
    TTCTT
    7 -- int10--------
    rs1899257461,2
    --93131038(+) ACACAC/TATATA 7 -- int10--------
    rs106040991,2
    C--93131057(+) tatat-/ATA/  
      ATAT
    /T
    ttttt
    14 -- int1 cds11NA 2
    rs1385085681,2
    C--93131057(+) TATAT-/ATATTTTT 7 -- int10--------
    rs79045281,2
    C--93139329(+) tttttG/Tttttt 7 -- int1 trp30--------
    rs720866021,2
    C--99495790(+) ATGTA-/GGA   
       AAGAG
    GGGGT
    6 -- us2k10--------
    rs710073611,2
    C--99498859(-) AAAAA-/AGTAGT 7 -- int11Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for ZFYVE27 (99496878 - 99520664 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZFYVE27:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272632CNV Insertion20981092

    Human Gene Mutation Database (HGMD): ZFYVE27
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFYVE27
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFYVE27

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610243   
    OMIM disorders: 610244  
    UniProtKB/Swiss-Prot: ZFY27_HUMAN, Q5T4F4
  • Spastic paraplegia 33, autosomal dominant (SPG33) [MIM:610244]: A form of spastic paraplegia, a
    neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower
    limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include
    difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking.
    In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness
    may spread to other parts of the body. Note=The disease is caused by mutations affecting the gene represented in
    this entry. According to PubMed:18606302, the properties of the variant Val-191 and its frequency in some
    populations raise doubts on the implication of that gene in the disease

  • 11 diseases for ZFYVE27:    
    About MalaCards
    spastic paraplegia 33    spastic paraplegia 33, autosomal dominant    hereditary spastic paraplegia    paraplegia
    spasticity    intrahepatic cholangiocarcinoma    cholangiocarcinoma    alzheimer's disease
    multiple myeloma    myeloma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ZFYVE27:
    Paraplegia

    ZFYVE27 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ZFYVE27
    Human Genome Epidemiology (HuGE) Navigator: ZFYVE27 (1 document)

    Export disorders for ZFYVE27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFYVE27 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with ZFYVE27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein. (PubMed id 19289470)1, 2 Saita S.... Nakayama K.I. (J. Biol. Chem. 2009)
    3. The role of ZFYVE27/protrudin in hereditary spastic paraplegia. (PubMed id 18606302)1, 2 Martignoni M.... Rugarli E.I. (Am. J. Hum. Genet. 2008)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. Protrudin induces neurite formation by directional membrane trafficking. (PubMed id 17082457)1, 2 Shirane M. and Nakayama K.I. (Science 2006)
    6. ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia. (PubMed id 16826525)1, 2 Mannan A.U.... Engel W. (Am. J. Hum. Genet. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation. (PubMed id 23969831)1 Chang J....Blackstone C. (Proc. Natl. Acad. Sci. U.S.A. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 118813 HGNC: 26559 AceView: ZFYVE27 Ensembl:ENSG00000155256 euGenes: HUgn118813
    ECgene: ZFYVE27 H-InvDB: ZFYVE27

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZFYVE27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZFYVE27 gene:
    Search GeneIP for patents involving ZFYVE27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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