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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFYVE26 Gene

protein-coding   GIFtS: 53
GCID: GC14M068194

Zinc Finger, FYVE Domain Containing 26

(Previous names: spastic paraplegia 15 (complicated, autosomal recessive))
(Previous symbol: SPG15)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, FYVE Domain Containing 261 2     KIAA03213 5
FYVE-CENT1 2 3     Spastic Paraplegia 15 (Complicated, Autosomal Recessive)1
SPG151 2 5     Zinc Finger FYVE Domain-Containing Protein 262
spastizin1 2     Spastizin3
FYVE Domain-Containing Centrosomal Protein2 3     

External Ids:    HGNC: 207611   Entrez Gene: 235032   Ensembl: ENSG000000721217   OMIM: 6120125   UniProtKB: Q68DK23   

Export aliases for ZFYVE26 gene to outside databases

Previous GC identifers: GC14M062006 GC14M066203 GC14M067282 GC14M048382


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZFYVE26 Gene:
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is
thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane.
Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. (provided by RefSeq, Oct
2008)

GeneCards Summary for ZFYVE26 Gene: 
ZFYVE26 (zinc finger, FYVE domain containing 26) is a protein-coding gene. Diseases associated with ZFYVE26 include spastic paraplegia 15, and paraplegia. GO annotations related to this gene include metal ion binding and phosphatidylinositol-3-phosphate binding.

UniProtKB/Swiss-Prot: ZFY26_HUMAN, Q68DK2
Function: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis:
recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for
efficient homologous recombination DNA double-strand break repair




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFYVE26 gene promoter:
         HFH-3   POU3F2   C/EBPalpha   FOXI1   PPAR-gamma1   FOXC1   FOXO4   USF-1   PPAR-gamma2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFYVE26 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFYVE26

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFYVE26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q23.3

ZFYVE26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFYVE26 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M068194:  view genomic region     (about GC identifiers)

Start:
68,194,091 bp from pter      End:
68,283,307 bp from pter
Size:
89,217 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZFY26_HUMAN, Q68DK2 (See protein sequence)
Recommended Name: Zinc finger FYVE domain-containing protein 26  
Size: 2539 amino acids; 284576 Da
Subunit: Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Localizes
to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A
Sequence caution: Sequence=BAG11658.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAD97882.1; Type=Erroneous termination; Positions=1463; Note=Translated as Gln;
Secondary accessions: B1B5Y3 B4E2U3 O15035 Q68DT9 Q6AW90 Q6ZR50 Q7Z3A4 Q7Z3I1 Q8N4W7
Alternative splicing: 4 isoforms:  Q68DK2-1   Q68DK2-2   Q68DK2-4   Q68DK2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFYVE26: NX_Q68DK2

Explore proteomics data for ZFYVE26 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q68DK2

  • ZFYVE26 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFYVE26 Protein Expression
    REFSEQ proteins: NP_056161.2  
    ENSEMBL proteins: 
     ENSP00000251119   ENSP00000450431   ENSP00000452142   ENSP00000450603  

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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005765lysosomal membrane IDA17897319
    GO:0005813centrosome IDA--
    GO:0030496midbody IDA--

    ZFYVE26 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZFYVE: Zinc fingers, FYVE domain containing

    4 InterPro protein domains:
     IPR000306 Znf_FYVE
     IPR017455 Znf_FYVE-rel
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q68DK2

    ProtoNet protein and cluster: Q68DK2

    1 Blocks protein domain: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: ZFY26_HUMAN, Q68DK2
    Domain: The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the
    midbody during cytokinesis
    Similarity: Contains 1 FYVE-type zinc finger


    ZFYVE26 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFY26_HUMAN, Q68DK2
    Function: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis:
    recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for
    efficient homologous recombination DNA double-strand break repair

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0032266phosphatidylinositol-3-phosphate binding IDA--
    GO:0046872metal ion binding IEA--
         
    ZFYVE26 for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidZFYVE26 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZFYVE26 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeletal Signaling
    Cytoskeletal Signaling
    2PI3K / Akt Signaling
    PI3K / Akt Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for ZFYVE26
        Cytoskeletal Signaling
    PI3K / Akt Signaling



    ZFYVE26 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFYVE26

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5 Interacting proteins for ZFYVE26 (Q68DK23 ENSP000002511194) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOC2Q96KP13I2D: score=4 
    NCAM2O153943I2D: score=1 
    SPAG5Q96R063I2D: score=1 
    SSX2IPQ9Y2D83I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination IMP--
    GO:0000910cytokinesis IMP--
    GO:0008219cell death IEA--

    ZFYVE26 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFYVE26 (ZFY26)

    Search CenterWatch for drugs/clinical trials and news about ZFYVE26 / ZFY26

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFYVE26 gene: 
    NM_015346.3  

    Unigene Cluster for ZFYVE26:

    Zinc finger, FYVE domain containing 26
    Hs.98041  [show with all ESTs]
    Unigene Representative Sequence: NM_015346
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394455 ENST00000347230(uc001xka.2 uc010tsz.1) ENST00000554557
    ENST00000554523 ENST00000557306(uc001xkb.3) ENST00000554783 ENST00000555452(uc001xkc.4)
    ENST00000557204 ENST00000557366(uc010tta.2) ENST00000557407 ENST00000553399


    miRNA
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    Additional mRNA sequence: 

    AB002319.1 AB425197.1 AK024743.1 AK055455.1 AK304428.1 AK308233.1 BC008927.2 BC013909.2 
    BC033235.1 BC144594.1 BX538025.1 BX648036.1 BX648683.1 CR749276.1 CR749365.1 

    13 DOTS entries:

    DT.315080  DT.100812129  DT.75103071  DT.75122974  DT.100775498  DT.101983955  DT.100650404  DT.40250645 
    DT.75195549  DT.101983954  DT.95359593  DT.91759756  DT.95089137 

    24/149 AceView cDNA sequences (see all 149):

    BQ184112 BX112682 BX538025 NM_015346 BQ066246 BQ058240 AB002319 BU859628 
    BU175284 BG059368 AL044061 AA614825 BQ012672 CF552568 BQ010951 BC033235 
    BX648683 BU930934 BM771053 BM988307 BC008927 BQ011604 CB269757 BX441741 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE26 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                -                                                                           
    SP2:              -                                   -                                                                                                         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b ^ 42
    SP1:                                                                    -                 -                                         -         
    SP2:                                                                                                                                          
    SP3:                                                                                      -                                                   
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for ZFYVE26

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFYVE26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZFYVE26 Expression
    About this image


    See ZFYVE26 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFYVE26

    SOURCE GeneReport for Unigene cluster: Hs.98041

    UniProtKB/Swiss-Prot: ZFY26_HUMAN, Q68DK2
    Tissue specificity: Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung,
    placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other
    structures, including the spinal cord

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZFYVE26 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfyve261 , 5 zinc finger, FYVE domain containing 261, 5 83.87(n)1
    82.9(a)1
      12 (35.51 cM)5
    2119781  NM_001008550.11  NP_001008550.11 
     792323475 
    chicken
    (Gallus gallus)
    Aves ZFYVE261 zinc finger, FYVE domain containing 26 64.56(n)
    62.48(a)
      423276  XM_421195.3  XP_421195.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZFYVE266
    zinc finger, FYVE domain containing 26
    58(a)
    1 ↔ 1
    GL343272.1(1106396-1157437)
    zebrafish
    (Danio rerio)
    Actinopterygii zfyve261 zinc finger, FYVE domain containing 26 54.55(n)
    48.59(a)
      324565  XM_003199733.1  XP_003199781.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG52706
    --
    21(a)
    1 ↔ 1
    3R(7247814-7255691)


    ENSEMBL Gene Tree for ZFYVE26 (if available)
    TreeFam Gene Tree for ZFYVE26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1737 SNPs in ZFYVE26 are shown (see all 1737)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0379964
    A breast cancer sample4--see VAR_0379962 R Q mis40--------
    VAR_0379934
    A breast cancer sample4--see VAR_0379932 A E mis40--------
    rs1182040491,2
    Cpathogenic149235619(-) ACGGGC/TGAGAT 2 R * stg11Minor allele frequency- T:0.00EU 1323
    rs1133656121,2
    C--48393936(+) TTTCTC/TTCTTT 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs3699822551,2
    C--48445446(+) AAGCA-/CTCTTTT 1 -- int10--------
    rs1488712431,2
    --49198845(+) ATCTGC/TAGTGG 1 -- ds50010--------
    rs1931699681,2
    --49198866(+) CAACAA/TCATAA 1 -- ds50010--------
    rs1833165381,2
    --49199050(+) ATAAAC/TGTATT 1 -- ds50010--------
    rs2022230491,2
    C--49199236(-) AGAAAA/GGGGAG 1 -- ds50010--------
    rs2002770261,2
    C--49199337(+) GGCTTG/TTNNNN 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZFYVE26 (68194091 - 68283307 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZFYVE26:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1323CNV Insertion18451855


    Human Gene Mutation Database (HGMD): ZFYVE26
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFYVE26
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFYVE26

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612012   
    OMIM disorders: 270700  
    UniProtKB/Swiss-Prot: ZFY26_HUMAN, Q68DK2
  • Spastic paraplegia 15, autosomal recessive (SPG15) [MIM:270700]: A form of spastic paraplegia, a
    neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower
    limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include
    difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking.
    In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness
    may spread to other parts of the body. SPG15 is a complex form associated with additional neurological symptoms
    such as cognitive deterioration or mental retardation, axonal neuropathy, mild cerebellar signs, and, less
    frequently, a central hearing deficit, decreased visual acuity, or retinal degeneration. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 11 diseases for ZFYVE26:    About MalaCards
    spastic paraplegia 15    paraplegia    spasticity    axonal neuropathy
    hereditary spastic paraplegia    optic atrophy    retinal degeneration    neuropathy
    retinitis    mental retardation    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ZFYVE26:
    Paraplegia

    ZFYVE26 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ZFYVE26
    Human Genome Epidemiology (HuGE) Navigator: ZFYVE26 (1 document)

    Export disorders for ZFYVE26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFYVE26 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with ZFYVE26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome. (PubMed id 18394578)1, 2, 3 Hanein S.... Stevanin G. (2008)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. PtdIns(3)P controls cytokinesis through KIF13A-mediat ed recruitment of FYVE-CENT to the midbody. (PubMed id 20208530)1, 2 Sagona A.P....Stenmark H. (2010)
    5. SPG15 is the second most common cause of hereditary s pastic paraplegia with thin corpus callosum. (PubMed id 19805727)1, 2 Goizet C....Stevanin G. (2009)
    6. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegi a. (PubMed id 21545838)1 Murmu R.P....Stevanin G. (2011)
    9. A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis. (PubMed id 21455500)1 Sagona A.P....Stenmark H. (2011)
    10. A genome-scale DNA repair RNAi screen identifies SPG4 8 as a novel gene associated with hereditary spastic paraplegia. (PubMed id 20613862)2 SA8abicki M....Buchholz F. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23503 HGNC: 20761 AceView: ZFYVE26 Ensembl:ENSG00000072121 euGenes: HUgn23503
    ECgene: ZFYVE26 H-InvDB: ZFYVE26

    (According to HUGE)
    About This Section
    HUGE: KIAA0321

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFYVE26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFYVE26 gene:
    Search GeneIP for patents involving ZFYVE26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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