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Aliases for ZFYVE26 Gene

Aliases for ZFYVE26 Gene

  • Zinc Finger, FYVE Domain Containing 26 2 3
  • Spastizin 2 3 4
  • FYVE-CENT 2 3 4
  • FYVE Domain-Containing Centrosomal Protein 3 4
  • KIAA0321 4 6
  • SPG15 3 6
  • Spastic Paraplegia 15 (Complicated, Autosomal Recessive) 2
  • Zinc Finger FYVE Domain-Containing Protein 26 3

External Ids for ZFYVE26 Gene

Previous HGNC Symbols for ZFYVE26 Gene

  • SPG15

Previous GeneCards Identifiers for ZFYVE26 Gene

  • GC14M062006
  • GC14M066203
  • GC14M067282
  • GC14M068194
  • GC14M048382

Summaries for ZFYVE26 Gene

Entrez Gene Summary for ZFYVE26 Gene

  • This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]

GeneCards Summary for ZFYVE26 Gene

ZFYVE26 (Zinc Finger, FYVE Domain Containing 26) is a Protein Coding gene. Diseases associated with ZFYVE26 include spastic paraplegia 15, autosomal recessive and spastic paraplegia 15. Among its related pathways are Cytoskeletal Signaling and PI3K / Akt Signaling. GO annotations related to this gene include phosphatidylinositol-3-phosphate binding.

UniProtKB/Swiss-Prot for ZFYVE26 Gene

  • Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFYVE26 Gene

Genomics for ZFYVE26 Gene

Regulatory Elements for ZFYVE26 Gene

Genomic Location for ZFYVE26 Gene

Start:
67,727,374 bp from pter
End:
67,816,590 bp from pter
Size:
89,217 bases
Orientation:
Minus strand

Genomic View for ZFYVE26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFYVE26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFYVE26 Gene

Proteins for ZFYVE26 Gene

  • Protein details for ZFYVE26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DK2-ZFY26_HUMAN
    Recommended name:
    Zinc finger FYVE domain-containing protein 26
    Protein Accession:
    Q68DK2
    Secondary Accessions:
    • B1B5Y3
    • B4E2U3
    • O15035
    • Q68DT9
    • Q6AW90
    • Q6ZR50
    • Q7Z3A4
    • Q7Z3I1
    • Q8N4W7

    Protein attributes for ZFYVE26 Gene

    Size:
    2539 amino acids
    Molecular mass:
    284576 Da
    Quaternary structure:
    • Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A.
    SequenceCaution:
    • Sequence=BAG11658.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD97882.1; Type=Erroneous termination; Positions=1463; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFYVE26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFYVE26 Gene

Proteomics data for ZFYVE26 Gene at MOPED

Post-translational modifications for ZFYVE26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFYVE26 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ZFYVE26 (ZFYVE26)

No data available for DME Specific Peptides for ZFYVE26 Gene

Domains for ZFYVE26 Gene

Gene Families for ZFYVE26 Gene

HGNC:
  • ZFYVE :Zinc fingers, FYVE domain containing

Protein Domains for ZFYVE26 Gene

Suggested Antigen Peptide Sequences for ZFYVE26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68DK2

UniProtKB/Swiss-Prot:

ZFY26_HUMAN :
  • Q68DK2
Domain:
  • The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis.
Similarity:
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with ZFYVE26: view

Function for ZFYVE26 Gene

Molecular function for ZFYVE26 Gene

UniProtKB/Swiss-Prot Function: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.

Gene Ontology (GO) - Molecular Function for ZFYVE26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20208530
GO:0032266 phosphatidylinositol-3-phosphate binding IDA 20208530
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFYVE26: view

Animal Model Products

CRISPR Products

miRNA for ZFYVE26 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFYVE26

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFYVE26 Gene

Localization for ZFYVE26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFYVE26 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFYVE26 Gene COMPARTMENTS Subcellular localization image for ZFYVE26 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ZFYVE26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005813 centrosome IDA 20208530
GO:0030496 midbody IDA 20208530
genes like me logo Genes that share ontologies with ZFYVE26: view

Pathways for ZFYVE26 Gene

genes like me logo Genes that share pathways with ZFYVE26: view

Pathways by source for ZFYVE26 Gene

2 Cell Signaling Technology pathways for ZFYVE26 Gene

Interacting Proteins for ZFYVE26 Gene

Gene Ontology (GO) - Biological Process for ZFYVE26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 20613862
GO:0000910 cytokinesis IMP 20208530
GO:0008219 cell death --
genes like me logo Genes that share ontologies with ZFYVE26: view

Transcripts for ZFYVE26 Gene

Unigene Clusters for ZFYVE26 Gene

Zinc finger, FYVE domain containing 26:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFYVE26

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZFYVE26

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE26 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b ^ 42
SP1: - - -
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for ZFYVE26 Gene

GeneLoc Exon Structure for
ZFYVE26
ECgene alternative splicing isoforms for
ZFYVE26

Expression for ZFYVE26 Gene

mRNA expression in normal human tissues for ZFYVE26 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFYVE26 Gene

SOURCE GeneReport for Unigene cluster for ZFYVE26 Gene Hs.98041

mRNA Expression by UniProt/SwissProt for ZFYVE26 Gene

Q68DK2-ZFY26_HUMAN
Tissue specificity: Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord.
genes like me logo Genes that share expressions with ZFYVE26: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZFYVE26 Gene

Orthologs for ZFYVE26 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFYVE26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFYVE26 35
  • 99.62 (n)
  • 99.53 (a)
ZFYVE26 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFYVE26 35
  • 87.32 (n)
  • 86.26 (a)
ZFYVE26 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFYVE26 35
  • 88.15 (n)
  • 86.49 (a)
ZFYVE26 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfyve26 35
  • 83.87 (n)
  • 82.9 (a)
Zfyve26 16
Zfyve26 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFYVE26 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfyve26 35
  • 83.39 (n)
  • 82.4 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 76 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
ZFYVE26 35
  • 64.67 (n)
  • 62.71 (a)
lizard
(Anolis carolinensis)
Reptilia ZFYVE26 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfyve26 35
  • 57.42 (n)
  • 51.87 (a)
zebrafish
(Danio rerio)
Actinopterygii zfyve26 35
  • 54.48 (n)
  • 48.54 (a)
zfyve26 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5270 36
  • 21 (a)
OneToOne
Species with no ortholog for ZFYVE26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFYVE26 Gene

ENSEMBL:
Gene Tree for ZFYVE26 (if available)
TreeFam:
Gene Tree for ZFYVE26 (if available)

Paralogs for ZFYVE26 Gene

No data available for Paralogs for ZFYVE26 Gene

Variants for ZFYVE26 Gene

Sequence variations from dbSNP and Humsavar for ZFYVE26 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs9449 -- 67,746,696(-) TAACT(A/C)ATTGA utr-variant-3-prime, intron-variant
rs10288 -- 67,747,027(-) GTGCT(C/T)AGAAA utr-variant-3-prime, intron-variant
rs181561 -- 67,814,902(+) AAACA(C/G)TATAG intron-variant
rs181562 -- 67,814,585(+) CTTTC(A/G)TAAAA intron-variant
rs181563 -- 67,814,131(+) CATCC(A/C)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFYVE26 Gene

Variant ID Type Subtype PubMed ID
nsv1323 CNV Insertion 18451855

Relevant External Links for ZFYVE26 Gene

HapMap Linkage Disequilibrium report
ZFYVE26
Human Gene Mutation Database (HGMD)
ZFYVE26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFYVE26 Gene

Disorders for ZFYVE26 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ZFYVE26 Gene including...

Search for ZFYVE26 Gene in MalaCards »

(1) OMIM Diseases for ZFYVE26 Gene (612012)

UniProtKB/Swiss-Prot

ZFY26_HUMAN
  • Spastic paraplegia 15, autosomal recessive (SPG15) [MIM:270700]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG15 is a complex form associated with additional neurological symptoms such as cognitive deterioration or mental retardation, axonal neuropathy, mild cerebellar signs, and, less frequently, a central hearing deficit, decreased visual acuity, or retinal degeneration. {ECO:0000269 PubMed:18394578, ECO:0000269 PubMed:19084844, ECO:0000269 PubMed:19805727}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ZFYVE26 Gene

Relevant External Links for ZFYVE26

Genetic Association Database (GAD)
ZFYVE26
Human Genome Epidemiology (HuGE) Navigator
ZFYVE26
genes like me logo Genes that share disorders with ZFYVE26: view

Publications for ZFYVE26 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome. (PMID: 18394578) Hanein S. … Stevanin G. (Am. J. Hum. Genet. 2008) 2 3 4
  3. SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum. (PMID: 19805727) Goizet C. … Stevanin G. (Neurology 2009) 3 4
  4. PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. (PMID: 20208530) Sagona A.P. … Stenmark H. (Nat. Cell Biol. 2010) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for ZFYVE26 Gene

Sources for ZFYVE26 Gene

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