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ZFYVE26 Gene

protein-coding   GIFtS: 53
GCID: GC14M068194

Zinc Finger, FYVE Domain Containing 26

(Previous names: spastic paraplegia 15 (complicated, autosomal recessive))
(Previous symbol: SPG15)
  See ZFYVE26-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, FYVE Domain Containing 261 2     KIAA03213 5
FYVE-CENT1 2 3     Spastic Paraplegia 15 (Complicated, Autosomal Recessive)1
SPG151 2 5     Zinc Finger FYVE Domain-Containing Protein 262
spastizin1 2     Spastizin3
FYVE Domain-Containing Centrosomal Protein2 3     

External Ids:    HGNC: 207611   Entrez Gene: 235032   Ensembl: ENSG000000721217   OMIM: 6120125   UniProtKB: Q68DK23   

Export aliases for ZFYVE26 gene to outside databases

Previous GC identifers: GC14M062006 GC14M066203 GC14M067282 GC14M048382


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZFYVE26 Gene:
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is
thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane.
Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. (provided by RefSeq, Oct
2008)

GeneCards Summary for ZFYVE26 Gene:
ZFYVE26 (zinc finger, FYVE domain containing 26) is a protein-coding gene. Diseases associated with ZFYVE26 include spastic paraplegia 15. GO annotations related to this gene include phosphatidylinositol-3-phosphate binding.

UniProtKB/Swiss-Prot: ZFY26_HUMAN, Q68DK2
Function: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis:
recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for
efficient homologous recombination DNA double-strand break repair




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFYVE26 gene promoter:
         HFH-3   POU3F2   C/EBPalpha   FOXI1   PPAR-gamma1   FOXC1   FOXO4   USF-1   PPAR-gamma2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFYVE26 promoter sequence
   Search Chromatin IP Primers for ZFYVE26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFYVE26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q23.3

ZFYVE26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFYVE26 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M068194:  view genomic region     (about GC identifiers)

Start:
68,194,091 bp from pter      End:
68,283,307 bp from pter
Size:
89,217 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZFY26_HUMAN, Q68DK2 (See protein sequence)
Recommended Name: Zinc finger FYVE domain-containing protein 26  
Size: 2539 amino acids; 284576 Da
Subunit: Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A
Sequence caution: Sequence=BAG11658.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAD97882.1; Type=Erroneous termination; Positions=1463; Note=Translated as Gln;
Secondary accessions: B1B5Y3 B4E2U3 O15035 Q68DT9 Q6AW90 Q6ZR50 Q7Z3A4 Q7Z3I1 Q8N4W7
Alternative splicing: 4 isoforms:  Q68DK2-1   Q68DK2-2   Q68DK2-4   Q68DK2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFYVE26: NX_Q68DK2

Explore proteomics data for ZFYVE26 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZFYVE26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056161.2  
    ENSEMBL proteins: 
     ENSP00000251119   ENSP00000450431   ENSP00000452142   ENSP00000450603  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFYVE: Zinc fingers, FYVE domain containing

    5 InterPro protein domains:
     IPR000306 Znf_FYVE
     IPR013083 Znf_RING/FYVE/PHD
     IPR017455 Znf_FYVE-rel
     IPR028730 ZFYVE26
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q68DK2

    ProtoNet protein and cluster: Q68DK2

    1 Blocks protein domain: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: ZFY26_HUMAN, Q68DK2
    Domain: The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the
    midbody during cytokinesis
    Similarity: Contains 1 FYVE-type zinc finger


    Find genes that share domains with ZFYVE26           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFY26_HUMAN, Q68DK2
    Function: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis:
    recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for
    efficient homologous recombination DNA double-strand break repair

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0032266phosphatidylinositol-3-phosphate binding IDA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZFYVE26           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZFYVE26

    miRNA
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    miRTarBase miRNAs that target ZFYVE26:
    hsa-mir-18b-5p (MIRT042414), hsa-mir-17-5p (MIRT051032), hsa-mir-92a-3p (MIRT049794), hsa-mir-340-5p (MIRT019559), hsa-mir-124-3p (MIRT022971)

    Block miRNA regulation of human, mouse, rat ZFYVE26 using miScript Target Protectors
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    hsa-miR-548j hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-30d hsa-miR-3921 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidZFYVE26 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZFY26_HUMAN, Q68DK2: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Localizes
    to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus3
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005813centrosome IDA--
    GO:0030496midbody IDA--

    Find genes that share ontologies with ZFYVE26           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZFYVE26 About    
    See pathways by source

    SuperPathContained pathways About
    1PI3K / Akt Signaling
    PI3K / Akt Signaling
    2Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with ZFYVE26           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for ZFYVE26
        Cytoskeletal Signaling
    PI3K / Akt Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFYVE26
    Interactions:

        Search GeneGlobe Interaction Network for ZFYVE26

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for ZFYVE26 (Q68DK23 ENSP000002511194) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCAM2O153943, ENSP000003833924I2D: score=1 STRING: ENSP00000383392
    EXOC2Q96KP13I2D: score=4 
    SPAG5Q96R063I2D: score=1 
    SSX2IPQ9Y2D83I2D: score=1 
    RANBP3ENSP000003414834STRING: ENSP00000341483
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination IMP--
    GO:0000910cytokinesis IMP--
    GO:0008219cell death IEA--

    Find genes that share ontologies with ZFYVE26           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFYVE26 (ZFY26)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZFYVE26 gene: 
    NM_015346.3  

    Unigene Cluster for ZFYVE26:

    Zinc finger, FYVE domain containing 26
    Hs.98041  [show with all ESTs]
    Unigene Representative Sequence: NM_015346
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394455 ENST00000347230(uc001xka.2 uc010tsz.1) ENST00000554557
    ENST00000554523 ENST00000557306(uc001xkb.3) ENST00000554783 ENST00000555452(uc001xkc.4)
    ENST00000557204 ENST00000557366(uc010tta.2) ENST00000557407 ENST00000553399

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    Selected qRT-PCR Assays for microRNAs that regulate ZFYVE26 (see all 85):
    hsa-miR-548j hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-30d hsa-miR-3921 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidZFYVE26 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat ZFYVE26

    Additional mRNA sequence: 

    AB002319.1 AB425197.1 AK024743.1 AK055455.1 AK304428.1 AK308233.1 BC008927.2 BC013909.2 
    BC033235.1 BC144594.1 BX538025.1 BX648036.1 BX648683.1 CR749276.1 CR749365.1 

    13 DOTS entries:

    DT.315080  DT.100812129  DT.75103071  DT.75122974  DT.100775498  DT.101983955  DT.100650404  DT.40250645 
    DT.75195549  DT.101983954  DT.95359593  DT.91759756  DT.95089137 

    Selected AceView cDNA sequences (see all 149):

    BQ184112 BX648683 CF552568 AA614825 BU859628 BU930934 BM988307 BC008927 
    BQ011604 BX538025 CB269757 BX441741 BU175284 NM_015346 BG059368 BM771053 
    AL044061 BQ012672 BQ058240 BQ066246 AB002319 BC033235 BQ010951 BX112682 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE26 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                -                                                                           
    SP2:              -                                   -                                                                                                         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b ^ 42
    SP1:                                                                    -                 -                                         -         
    SP2:                                                                                                                                          
    SP3:                                                                                      -                                                   
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for ZFYVE26

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFYVE26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZFYVE26 Expression
    About this image

    ZFYVE26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFYVE26 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98041

    UniProtKB/Swiss-Prot: ZFY26_HUMAN, Q68DK2
    Tissue specificity: Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung,
    placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other
    structures, including the spinal cord

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFYVE26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZFYVE26 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfyve261 , 5 zinc finger, FYVE domain containing 261, 5 83.87(n)1
    82.9(a)1
      12 (35.51 cM)5
    2119781  NM_001008550.11  NP_001008550.11 
     792323475 
    chicken
    (Gallus gallus)
    Aves ZFYVE261 zinc finger, FYVE domain containing 26 64.67(n)
    62.71(a)
      423276  XM_004941715.1  XP_004941772.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZFYVE266
    zinc finger, FYVE domain containing 26
    58(a)
    1 ↔ 1
    GL343272.1(1106396-1157437)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia zfyve261 zinc finger, FYVE domain containing 26 57.42(n)
    51.87(a)
      100492179  XM_002937207.2  XP_002937253.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zfyve261 zinc finger, FYVE domain containing 26 54.48(n)
    48.54(a)
      324565  XM_003199733.2  XP_003199781.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG52706
    --
    21(a)
    1 ↔ 1
    3R(7247814-7255691)


    ENSEMBL Gene Tree for ZFYVE26 (if available)
    TreeFam Gene Tree for ZFYVE26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFYVE26 (see all 1737)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0379964
    A breast cancer sample4--see VAR_0379962 R Q mis40--------
    VAR_0379934
    A breast cancer sample4--see VAR_0379932 A E mis40--------
    rs1182040491,2
    Cpathogenic149235619(-) ACGGGC/TGAGAT 2 R * stg11Minor allele frequency- T:0.00EU 1323
    rs1133656121,2
    C--48393936(+) TTTCTC/TTCTTT 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs3699822551,2
    C--48445446(+) AAGCA-/CTCTTTT 1 -- int10--------
    rs1488712431,2
    --49198845(+) ATCTGC/TAGTGG 1 -- ds50010--------
    rs1931699681,2
    --49198866(+) CAACAA/TCATAA 1 -- ds50010--------
    rs1833165381,2
    --49199050(+) ATAAAC/TGTATT 1 -- ds50010--------
    rs2022230491,2
    C--49199236(-) AGAAAA/GGGGAG 1 -- ds50010--------
    rs2002770261,2
    C--49199337(+) GGCTTG/TTNNNN 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZFYVE26 (68194091 - 68283307 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZFYVE26:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1323CNV Insertion18451855

    Human Gene Mutation Database (HGMD): ZFYVE26
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFYVE26
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFYVE26

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612012   
    OMIM disorders: 270700  
    UniProtKB/Swiss-Prot: ZFY26_HUMAN, Q68DK2
  • Spastic paraplegia 15, autosomal recessive (SPG15) [MIM:270700]: A form of spastic paraplegia, a
    neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower
    limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include
    difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking.
    In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness
    may spread to other parts of the body. SPG15 is a complex form associated with additional neurological symptoms
    such as cognitive deterioration or mental retardation, axonal neuropathy, mild cerebellar signs, and, less
    frequently, a central hearing deficit, decreased visual acuity, or retinal degeneration. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 1 disease for ZFYVE26:    
    About MalaCards
    spastic paraplegia 15

    1 disease from the University of Copenhagen DISEASES database for ZFYVE26:
    Paraplegia

    Find genes that share disorders with ZFYVE26           About GenesLikeMe

    Genetic Association Database (GAD): ZFYVE26
    Human Genome Epidemiology (HuGE) Navigator: ZFYVE26 (1 document)

    Export disorders for ZFYVE26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFYVE26 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with ZFYVE26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome. (PubMed id 18394578)1, 2, 3 Hanein S.... Stevanin G. (Am. J. Hum. Genet. 2008)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1997)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. (PubMed id 20208530)1, 2 Sagona A.P.... Stenmark H. (Nat. Cell Biol. 2010)
    5. SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum. (PubMed id 19805727)1, 2 Goizet C.... Stevanin G. (Neurology 2009)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15. (PubMed id 24030950)1 Vantaggiato C....Bassi M.T. (Brain 2013)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia. (PubMed id 21545838)1 Murmu R.P....Stevanin G. (Mol. Cell. Neurosci. 2011)
    10. A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis. (PubMed id 21455500)1 Sagona A.P....Stenmark H. (PLoS ONE 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23503 HGNC: 20761 AceView: ZFYVE26 Ensembl:ENSG00000072121 euGenes: HUgn23503
    ECgene: ZFYVE26 H-InvDB: ZFYVE26

    (According to HUGE)
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    HUGE: KIAA0321

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZFYVE26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFYVE26 gene:
    Search GeneIP for patents involving ZFYVE26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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