Aliases for ZFYVE26 Gene
External Ids for ZFYVE26 Gene
Previous HGNC Symbols for ZFYVE26 Gene
Previous GeneCards Identifiers for ZFYVE26 Gene
This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]
GeneCards Summary for ZFYVE26 Gene
ZFYVE26 (Zinc Finger FYVE-Type Containing 26) is a Protein Coding gene. Diseases associated with ZFYVE26 include Spastic Paraplegia 15, Autosomal Recessive and Spastic Paraplegia 15. Among its related pathways are Cytoskeletal Signaling and PI3K / Akt Signaling. GO annotations related to this gene include phosphatidylinositol-3-phosphate binding. An important paralog of this gene is PLEKHF1.
UniProtKB/Swiss-Prot for ZFYVE26 Gene
Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.