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Aliases for ZFYVE26 Gene

Aliases for ZFYVE26 Gene

  • Zinc Finger FYVE-Type Containing 26 2 3
  • Zinc Finger, FYVE Domain Containing 26 2 3 5
  • Spastizin 2 3 4
  • FYVE-CENT 2 3 4
  • FYVE Domain-Containing Centrosomal Protein 3 4
  • Spastic Paraplegia 15 (Complicated, Autosomal Recessive) 2
  • KIAA0321 4
  • SPG15 3

External Ids for ZFYVE26 Gene

Previous HGNC Symbols for ZFYVE26 Gene

  • SPG15

Previous GeneCards Identifiers for ZFYVE26 Gene

  • GC14M062006
  • GC14M066203
  • GC14M067282
  • GC14M068194
  • GC14M048382

Summaries for ZFYVE26 Gene

Entrez Gene Summary for ZFYVE26 Gene

  • This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]

GeneCards Summary for ZFYVE26 Gene

ZFYVE26 (Zinc Finger FYVE-Type Containing 26) is a Protein Coding gene. Diseases associated with ZFYVE26 include spastic paraplegia 15, autosomal recessive and spastic paraplegia 15. GO annotations related to this gene include phosphatidylinositol-3-phosphate binding.

UniProtKB/Swiss-Prot for ZFYVE26 Gene

  • Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFYVE26 Gene

Genomics for ZFYVE26 Gene

Regulatory Elements for ZFYVE26 Gene

Promoters for ZFYVE26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZFYVE26 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZFYVE26 Gene

Chromosome:
14
Start:
67,727,374 bp from pter
End:
67,816,611 bp from pter
Size:
89,238 bases
Orientation:
Minus strand

Genomic View for ZFYVE26 Gene

Genes around ZFYVE26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFYVE26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFYVE26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFYVE26 Gene

Proteins for ZFYVE26 Gene

  • Protein details for ZFYVE26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DK2-ZFY26_HUMAN
    Recommended name:
    Zinc finger FYVE domain-containing protein 26
    Protein Accession:
    Q68DK2
    Secondary Accessions:
    • B1B5Y3
    • B4E2U3
    • O15035
    • Q68DT9
    • Q6AW90
    • Q6ZR50
    • Q7Z3A4
    • Q7Z3I1
    • Q8N4W7

    Protein attributes for ZFYVE26 Gene

    Size:
    2539 amino acids
    Molecular mass:
    284576 Da
    Quaternary structure:
    • Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A.
    SequenceCaution:
    • Sequence=BAG11658.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD97882.1; Type=Erroneous termination; Positions=1463; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFYVE26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFYVE26 Gene

Proteomics data for ZFYVE26 Gene at MOPED

Post-translational modifications for ZFYVE26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFYVE26 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ZFYVE26 (ZFYVE26)

No data available for DME Specific Peptides for ZFYVE26 Gene

Domains & Families for ZFYVE26 Gene

Gene Families for ZFYVE26 Gene

Protein Domains for ZFYVE26 Gene

Suggested Antigen Peptide Sequences for ZFYVE26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68DK2

UniProtKB/Swiss-Prot:

ZFY26_HUMAN :
  • The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis.
  • Contains 1 FYVE-type zinc finger.
Domain:
  • The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis.
Similarity:
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with ZFYVE26: view

Function for ZFYVE26 Gene

Molecular function for ZFYVE26 Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.

Gene Ontology (GO) - Molecular Function for ZFYVE26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032266 phosphatidylinositol-3-phosphate binding IEA,IDA 20208530
genes like me logo Genes that share ontologies with ZFYVE26: view
genes like me logo Genes that share phenotypes with ZFYVE26: view

Human Phenotype Ontology for ZFYVE26 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ZFYVE26 Gene

MGI Knock Outs for ZFYVE26:

Animal Model Products

CRISPR Products

miRNA for ZFYVE26 Gene

miRTarBase miRNAs that target ZFYVE26

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ZFYVE26 Gene

Localization for ZFYVE26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFYVE26 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFYVE26 Gene COMPARTMENTS Subcellular localization image for ZFYVE26 gene
Compartment Confidence
cytoskeleton 5
lysosome 5
vacuole 5
cytosol 3
nucleus 3
endosome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ZFYVE26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
genes like me logo Genes that share ontologies with ZFYVE26: view

Pathways & Interactions for ZFYVE26 Gene

SuperPathways for ZFYVE26 Gene

No Data Available

Interacting Proteins for ZFYVE26 Gene

Gene Ontology (GO) - Biological Process for ZFYVE26 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZFYVE26 Gene

Drugs & Compounds for ZFYVE26 Gene

No Compound Related Data Available

Transcripts for ZFYVE26 Gene

Unigene Clusters for ZFYVE26 Gene

Zinc finger, FYVE domain containing 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE26 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b ^ 42
SP1: - - -
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for ZFYVE26 Gene

GeneLoc Exon Structure for
ZFYVE26
ECgene alternative splicing isoforms for
ZFYVE26

Expression for ZFYVE26 Gene

mRNA expression in normal human tissues for ZFYVE26 Gene

Protein differential expression in normal tissues from HIPED for ZFYVE26 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.4), Blymphocyte (15.2), Pancreas (12.2), and Placenta (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFYVE26 Gene



SOURCE GeneReport for Unigene cluster for ZFYVE26 Gene Hs.98041

mRNA Expression by UniProt/SwissProt for ZFYVE26 Gene

Q68DK2-ZFY26_HUMAN
Tissue specificity: Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord.
genes like me logo Genes that share expression patterns with ZFYVE26: view

Protein tissue co-expression partners for ZFYVE26 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZFYVE26 Gene

Orthologs for ZFYVE26 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFYVE26 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZFYVE26 35
  • 87.32 (n)
  • 86.26 (a)
ZFYVE26 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFYVE26 35
  • 88.15 (n)
  • 86.49 (a)
ZFYVE26 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfyve26 35
  • 83.87 (n)
  • 82.9 (a)
Zfyve26 16
Zfyve26 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZFYVE26 35
  • 99.62 (n)
  • 99.53 (a)
ZFYVE26 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfyve26 35
  • 83.39 (n)
  • 82.4 (a)
oppossum
(Monodelphis domestica)
Mammalia ZFYVE26 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZFYVE26 35
  • 64.67 (n)
  • 62.71 (a)
-- 36
  • 76 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZFYVE26 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfyve26 35
  • 57.42 (n)
  • 51.87 (a)
zebrafish
(Danio rerio)
Actinopterygii zfyve26 35
  • 54.48 (n)
  • 48.54 (a)
zfyve26 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5270 36
  • 21 (a)
OneToOne
Species with no ortholog for ZFYVE26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFYVE26 Gene

ENSEMBL:
Gene Tree for ZFYVE26 (if available)
TreeFam:
Gene Tree for ZFYVE26 (if available)

Paralogs for ZFYVE26 Gene

No data available for Paralogs for ZFYVE26 Gene

Variants for ZFYVE26 Gene

Sequence variations from dbSNP and Humsavar for ZFYVE26 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs34059852 - 67,804,251(+) TCTCT(C/T)TGGTA reference, missense, utr-variant-5-prime
rs17192170 - 67,790,635(+) AATGG(A/T)GCTGC reference, missense
rs35471427 - 67,789,502(+) GAGCC(A/C/G)TGCTT reference, missense
rs7156206 - 67,785,950(+) TTAGG(C/T)TGGGC reference, missense
rs3742885 - 67,785,274(+) TCCTG(A/G)GCTCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZFYVE26 Gene

Variant ID Type Subtype PubMed ID
nsv1323 CNV Insertion 18451855

Variation tolerance for ZFYVE26 Gene

Residual Variation Intolerance Score: 9.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.10; 90.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFYVE26 Gene

HapMap Linkage Disequilibrium report
ZFYVE26
Human Gene Mutation Database (HGMD)
ZFYVE26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFYVE26 Gene

Disorders for ZFYVE26 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ZFYVE26 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spastic paraplegia 15, autosomal recessive
  • kjellin syndrome
spastic paraplegia 15
  • kjellin syndrome
paraplegia
  • paraplegia, lower
vici syndrome
  • immunodeficiency with cleft lip/palate, cataract, hypopigmentation, and absent corpus callosum
axonal neuropathy
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZFY26_HUMAN
  • Spastic paraplegia 15, autosomal recessive (SPG15) [MIM:270700]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG15 is a complex form associated with additional neurological symptoms such as cognitive deterioration or mental retardation, axonal neuropathy, mild cerebellar signs, and, less frequently, a central hearing deficit, decreased visual acuity, or retinal degeneration. {ECO:0000269 PubMed:18394578, ECO:0000269 PubMed:19084844, ECO:0000269 PubMed:19805727}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZFYVE26

Genetic Association Database (GAD)
ZFYVE26
Human Genome Epidemiology (HuGE) Navigator
ZFYVE26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFYVE26
genes like me logo Genes that share disorders with ZFYVE26: view

No data available for Genatlas for ZFYVE26 Gene

Publications for ZFYVE26 Gene

  1. Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome. (PMID: 18394578) Hanein S. … Stevanin G. (Am. J. Hum. Genet. 2008) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3
  3. SPG15: a cause of juvenile atypical levodopa responsive parkinsonism. (PMID: 24366652) Mallaret M. … Tranchant C. (J. Neurol. 2014) 3
  4. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T. … Xu R. (Neurobiol. Aging 2014) 3
  5. Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation. (PMID: 25365221) Chang J. … Blackstone C. (J. Clin. Invest. 2014) 3

Products for ZFYVE26 Gene

Sources for ZFYVE26 Gene

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