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ZFYVE21 Gene

protein-coding   GIFtS: 49
GCID: GC14P104182

Zinc Finger, FYVE Domain Containing 21

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, FYVE Domain Containing 211 2
ZF212 3 5
FYVE Domain Containing 212
Zinc Finger FYVE Domain-Containing Protein 212

External Ids:    HGNC: 207601   Entrez Gene: 790382   Ensembl: ENSG000001007117   OMIM: 6135045   UniProtKB: Q9BQ243   

Export aliases for ZFYVE21 gene to outside databases

Previous GC identifers: GC14P097997 GC14P102172 GC14P103251 GC14P084360


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZFYVE21 Gene:
ZFYVE21 (zinc finger, FYVE domain containing 21) is a protein-coding gene. An important paralog of this gene is ZFYVE9.

UniProtKB/Swiss-Prot: ZFY21_HUMAN, Q9BQ24
Function: Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and
disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for
focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFYVE21 gene promoter:
         GR   p53   GR-beta   C/EBPalpha   CHOP-10   PPAR-gamma1   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFYVE21 promoter sequence
   Search Chromatin IP Primers for ZFYVE21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFYVE21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

ZFYVE21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFYVE21 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P104182:  view genomic region     (about GC identifiers)

Start:
104,182,067 bp from pter      End:
104,200,005 bp from pter
Size:
17,939 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZFY21_HUMAN, Q9BQ24 (See protein sequence)
Recommended Name: Zinc finger FYVE domain-containing protein 21  
Size: 234 amino acids; 26506 Da
Subunit: Interacts with PTK2/FAK1
Sequence caution: Sequence=CAD62589.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ZFYVE21:
2RRF (3D)    
Secondary accessions: A8K3A4 Q86T05 Q96LT1
Alternative splicing: 2 isoforms:  Q9BQ24-1   Q9BQ24-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFYVE21: NX_Q9BQ24

Explore proteomics data for ZFYVE21 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZFYVE21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001185882.1  NP_076976.1  

    ENSEMBL proteins: 
     ENSP00000216602   ENSP00000310543   ENSP00000450746   ENSP00000452301   ENSP00000473477  

    ZFYVE21 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZFYVE21

     
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    antibodies-online proteins for ZFYVE21 (6 products) 

     
    antibodies-online peptides for ZFYVE21

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFYVE: Zinc fingers, FYVE domain containing

    4 InterPro protein domains:
     IPR000306 Znf_FYVE
     IPR013083 Znf_RING/FYVE/PHD
     IPR017455 Znf_FYVE-rel
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q9BQ24

    ProtoNet protein and cluster: Q9BQ24

    1 Blocks protein domain: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: ZFY21_HUMAN, Q9BQ24
    Domain: The FYVE-type zinc finger mediates interaction with PTK2/FAK1, and also interaction with PI(3)P and
    association with endosomes
    Domain: The C-terminal region exhibits a structure similar to canonical PH domains, but lacks a positively charged
    interface to bind phosphatidylinositol phosphate
    Similarity: Contains 1 FYVE-type zinc finger


    Find genes that share domains with ZFYVE21           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFY21_HUMAN, Q9BQ24
    Function: Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and
    disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for
    focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZFYVE21           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZFYVE21:
     Decreased cell number  Increased cell size 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZFYVE21

    miRNA
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    miRTarBase miRNAs that target ZFYVE21:
    hsa-mir-484 (MIRT042353)

    Block miRNA regulation of human, mouse, rat ZFYVE21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFYVE21 (see all 16):
    hsa-miR-142-5p hsa-miR-3910 hsa-miR-300 hsa-miR-25 hsa-miR-124 hsa-miR-548g hsa-miR-4325 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidZFYVE21 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZFYVE21 (NM_024071)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFYVE21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZFY21_HUMAN, Q9BQ24: Cell junction, focal adhesion. Cytoplasmic vesicle. Endosome. Note=Within cytoplasmic
    vesicles, partially colocalizes with EEA1, an endosomal marker
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular3
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IEA--
    GO:0005925focal adhesion IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    Find genes that share ontologies with ZFYVE21           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFYVE21
    Interactions:

        Search GeneGlobe Interaction Network for ZFYVE21

    2 Interacting proteins for ZFYVE21 (Q9BQ243) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRTAP4-12Q9BQ663I2D: score=1 
    PLSCR1O151623I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFYVE21 (ZFY21)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZFYVE21 gene (2 alternative transcripts): 
    NM_001198953.1  NM_024071.3  

    Unigene Cluster for ZFYVE21:

    Zinc finger, FYVE domain containing 21
    Hs.592322  [show with all ESTs]
    Unigene Representative Sequence: AK226142
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216602(uc001yod.3 uc001yoc.3) ENST00000554255 ENST00000311141
    ENST00000553512 ENST00000554630 ENST00000556610 ENST00000555501 ENST00000553724
    ENST00000555163 ENST00000556795 ENST00000602552 ENST00000554757(uc001yoe.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat ZFYVE21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFYVE21 (see all 16):
    hsa-miR-142-5p hsa-miR-3910 hsa-miR-300 hsa-miR-25 hsa-miR-124 hsa-miR-548g hsa-miR-4325 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidZFYVE21 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZFYVE21 (NM_024071)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZFYVE21
      QuantiTect SYBR Green Assays in human, mouse, rat ZFYVE21
      QuantiFast Probe-based Assays in human, mouse, rat ZFYVE21

    Additional mRNA sequence: 

    AK001921.1 AK055909.1 AK057816.1 AK124507.1 AK226142.1 AK290519.1 AY395756.1 AY596776.1 
    BC001130.2 BC005999.1 BX248261.1 

    9 DOTS entries:

    DT.95174073  DT.100731929  DT.120749018  DT.100885079  DT.92029906  DT.120749073  DT.92448691  DT.120749079 
    DT.86843725 

    Selected AceView cDNA sequences (see all 180):

    CR622229 AI206211 AA411713 BQ689540 CB306186 BM767054 BM980786 BF593269 
    BI832937 BI766914 AI913171 BC005999 AA253153 AI201691 BF344182 AI869045 
    AW264930 BM788893 BF062003 AK001921 BF511582 CA311020 AA781664 AW189488 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE21 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                                      -     -           -                       -           -                           
    SP2:                                      -     -           -                       -           -                           
    SP3:                                      -     -           -                       -     -     -                           
    SP4:                                      -     -           -                                                               
    SP5:                                      -                 -                                                               


    ECgene alternative splicing isoforms for ZFYVE21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFYVE21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTAGAATT
    ZFYVE21 Expression
    About this image

    ZFYVE21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFYVE21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592322
        Custom PCR Arrays for ZFYVE21
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZFYVE21 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfyve211 , 5 zinc finger, FYVE domain containing 211, 5 83.9(n)1
    84.62(a)1
      12 (61.14 cM)5
    685201  NM_026752.41  NP_081028.31 
     1118141705 
    chicken
    (Gallus gallus)
    Aves ZFYVE211 zinc finger, FYVE domain containing 21 76.5(n)
    76.64(a)
      423486  NM_001277520.1  NP_001264449.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZFYVE216
    zinc finger, FYVE domain containing 21
    76(a)
    1 ↔ 1
    1(6002325-6024410)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.241822 Xenopus laevis transcribed sequence with moderate similarity more 81.12(n)    CA986120.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb66b012 wufb66b01 74.66(n)   322576  BM035954.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sara6
    Smad anchor for receptor activation
    4(a)
    many ↔ many
    2R(17369424-17374618)
    worm
    (Caenorhabditis elegans)
    Secernentea aka-16
    Protein AKA-1, isoform c (aka-1) mRNA, complete cd...
    5(a)
    1 ↔ 1
    II(7472729-7478959) WBGene00000101
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAB16
    1-phosphatidylinositol-3-phosphate 5-kinase; vacuo...
    2(a)
    1 → many
    VI(184502-191338) YFR019W


    ENSEMBL Gene Tree for ZFYVE21 (if available)
    TreeFam Gene Tree for ZFYVE21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZFYVE21 gene
    ZFYVE92  PIKFYVE2  ZFYVE162  ZFYVE282  

    Find genes that share paralogs with ZFYVE21           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFYVE21 (see all 395)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1149328991,2
    F--104183843(+) GTTCCC/TCTCCT 2 -- int11Minor allele frequency- T:0.01WA 118
    rs777930291,2
    C,F--104183935(+) GGCACT/CGTGTG 2 -- int11Minor allele frequency- C:0.12WA 118
    rs1172205411,2
    F--104184032(+) CGCTGG/ACGTGG 2 -- int11Minor allele frequency- A:0.03EA 120
    rs1471342601,2
    --104184033(+) GCTGGC/TGTGGT 2 -- int10--------
    rs1907246721,2
    --104184075(+) GTTTGA/GATGAT 2 -- int10--------
    rs1426352081,2
    C--104184084(+) TTAAC-/TGGG  
            
    TGGGA
    2 -- int10--------
    rs778446821,2
    C,F--104184115(+) CCTAGC/GATTGG 2 -- int12Minor allele frequency- G:0.10WA NA 238
    rs1394217691,2
    C--104184120(+) CATTGG/TGTGGG 2 -- int10--------
    rs1500524681,2
    C--104184196(+) TATTGA/GAGCAT 2 -- int10--------
    rs1453586571,2
    --104184253(+) TAGAAC/TGGGGC 2 -- int10--------

    HapMap Linkage Disequilibrium report for ZFYVE21 (104182067 - 104200005 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZFYVE21 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv902308CNV Loss21882294
    nsv902313CNV Loss21882294
    dgv1996n71CNV Loss21882294
    dgv1995n71CNV Loss21882294
    nsv470673CNV Loss18288195
    nsv902300CNV Loss21882294
    nsv527425CNV Loss19592680
    nsv902315CNV Loss21882294
    nsv827071CNV Gain20364138
    nsv9171CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFYVE21
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613504    OMIM disorders: --


    Find genes that share disorders with ZFYVE21           About GenesLikeMe

    Genetic Association Database (GAD): ZFYVE21
    Human Genome Epidemiology (HuGE) Navigator: ZFYVE21 (2 documents)

    Export disorders for ZFYVE21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFYVE21 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ZFYVE21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain. (PubMed id 21768110)1, 2, 3 Nagano M.... Seiki M. (J. Biol. Chem. 2011)
    2. Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma. (PubMed id 20601096)1, 4 Figl A....Kumar R. (Mutat. Res. 2010)
    3. ZF21 protein regulates cell adhesion and motility. (PubMed id 20439989)1, 2 Nagano M....Seiki M. (J. Biol. Chem. 2010)
    4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The phosphoinositide-binding protein ZF21 regulates ECM degradation by invadopodia. (PubMed id 23382803)1 Hoshino D....Seiki M. (PLoS ONE 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center. (PubMed id 20890123)1 Nagano M....Seiki M. (amp 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79038 HGNC: 20760 AceView: ZFYVE21 Ensembl:ENSG00000100711 euGenes: HUgn79038
    ECgene: ZFYVE21 H-InvDB: ZFYVE21

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZFYVE21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFYVE21 gene:
    Search GeneIP for patents involving ZFYVE21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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