ZFYVE21 Gene
protein-coding GIFtS: 46
GCID: GC14P104182
|
|
zinc finger, FYVE domain containing 21
| |
Aliases
for ZFYVE21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, FYVE Domain Containing 211 2 | | ZF211 2 3 5 | | MGC25501 | | FYVE Domain Containing 212 | | Zinc Finger FYVE Domain-Containing Protein 212 |
Export aliases for ZFYVE21 gene to outside databasesPrevious GC identifers: GC14P097997 GC14P102172 GC14P103251 GC14P084360 |
Summaries
for ZFYVE21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZFY21_HUMAN, Q9BQ24Function: Plays a role in cell adhesion, and thereby in cell motility, regulating microtubule-induced PTK2/FAK1dephosphorylation, an event important for focal adhesion disassemblya, as well as integrin beta-1/ITGB1 cell surfaceexpression
|
Genomic Views
for ZFYVE21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZFYVE21 gene promoter:
GR p53 GR-beta C/EBPalpha CHOP-10 PPAR-gamma1 GR-alpha PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZFYVE21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFYVE21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.33 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.33ZFYVE21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P104182: view genomic region
(about GC identifiers)
Start:
|
104,182,067 bp from pter |
End:
|
104,200,005 bp from pter |
Size:
|
17,939 bases |
Orientation:
|
plus strand |
|
Proteins
for ZFYVE21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZFY21_HUMAN, Q9BQ24 (See
protein sequence)Recommended Name: Zinc finger FYVE domain-containing protein 21 Size: 234 amino acids; 26506 Da
Subunit: Interacts with PTK2/FAK1
Subcellular location: Cell junction, focal adhesion. Cytoplasmic vesicle. Note=Within cytoplasmic vesicles, partiallycolocalizes with EEA1, an endosomal marker
Sequence caution: Sequence=CAD62589.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for ZFYVE21:2RRF (3D)
Secondary accessions: A8K3A4 Q86T05 Q96LT1Alternative splicing: 2 isoforms: Q9BQ24-1 Q9BQ24-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZFYVE21: NX_Q9BQ24
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BQ24
ZFYVE21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001185882.1 NP_076976.1
ENSEMBL proteins: ENSP00000216602 ENSP00000310543 ENSP00000450746 ENSP00000452301
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005925 | focal adhesion |
IEA | -- | | GO:0016023 | cytoplasmic membrane-bounded vesicle |
IEA | -- |
ZFYVE21 for ontologies About GeneDecksing
ZFYVE21 Antibody Products:
Assay Products for ZFYVE21: |
Protein
Domains /
Families
for ZFYVE21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZFYVE21 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BQ24ProtoNet protein and cluster: Q9BQ24 1 Blocks protein family: IPB000306 Zn-finger
UniProtKB/Swiss-Prot: ZFY21_HUMAN, Q9BQ24Similarity: Contains 1 FYVE-type zinc finger |
Function
for ZFYVE21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZFY21_HUMAN, Q9BQ24Function: Plays a role in cell adhesion, and thereby in cell motility, regulating microtubule-induced PTK2/FAK1dephosphorylation, an event important for focal adhesion disassemblya, as well as integrin beta-1/ITGB1 cell surfaceexpression
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFYVE21 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFYVE21
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFYVE21 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- |
ZFYVE21 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZFYVE21:
|
Pathways & Interactions
for ZFYVE21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFYVE21
2 Interacting proteins for ZFYVE21 (Q9BQ243) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZFYVE21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZFYVE21
Search CenterWatch for drugs/clinical trials and news about ZFYVE21 / ZFY21
|
Transcripts
for ZFYVE21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZFYVE21 gene (2 alternative transcripts): NM_001198953.1 NM_024071.3 Unigene Cluster for ZFYVE21: Zinc finger, FYVE domain containing 21 Hs.592322 [show with all ESTs]Unigene Representative Sequence: AK22614211 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000216602(uc001yod.3 uc001yoc.3) ENST00000554255 ENST00000311141
ENST00000553512 ENST00000554630 ENST00000556610 ENST00000555501 ENST00000553724
ENST00000556795 ENST00000555163 ENST00000554757(uc001yoe.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFYVE21 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFYVE21
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZFYVE21 (NM_024071) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZFYVE21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFYVE21 |
Additional cDNA sequence: AK001921.1 AK055909.1 AK057816.1 AK124507.1 AK226142.1 AK290519.1 AY395756.1 AY596776.1 BC001130.2 BC005999.1 BX248261.1 9 DOTS entries: DT.95174073 DT.100731929 DT.120749018 DT.100885079 DT.92029906 DT.120749073 DT.92448691 DT.120749079 DT.86843725 24/180 AceView cDNA sequences (see all 180): CA311020 BC005999 AI471777 BM980786 AW189488 BF062003 BF511582 CB306186 AW002075 AA236715 AA781664 BM767054 AI206211 BM796682 AW085225 BM552542 BI766914 NM_024071 CR622229 AI869045 AA253154 AI201691 AW264930 AA373633
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE21 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZFYVE21
|
Expression
for ZFYVE21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZFYVE21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTAGAATT
About this image
See ZFYVE21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZFYVE21
SOURCE GeneReport for Unigene cluster: Hs.592322
SABiosciences Custom PCR Arrays for ZFYVE21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFYVE21
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFYVE21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFYVE21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFYVE21 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFYVE21 |
Orthologs
for ZFYVE21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZFYVE21 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZFYVE211 |
zinc finger, FYVE domain containing 21 |
76.5(n)
76.64(a) |
|
423486 XM_421391.3 XP_421391.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ZFYVE216 |
-- |
75(a) |
1 ↔ 1 |
1(6002325-6024177) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.241822 |
Xenopus laevis transcribed sequence with moderate similarity more |
81.12(n) |
|
CA986120.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb66b012 |
wufb66b01 |
74.66(n) |
|
322576 BM035954.1 |
ENSEMBL Gene Tree for ZFYVE21 (if available)
TreeFam Gene Tree for ZFYVE21 (if available) |
Paralogs
for ZFYVE21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZFYVE21 gene
- PIKFYVE2 ZFYVE282
ZFYVE21 for paralogs About GeneDecksing
|
Genomic Variants
for ZFYVE21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZFYVE21 (104182067 - 104200005 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZFYVE21
1 CNV: 3949 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFYVE21 |
|
Disorders
/ Diseases
for ZFYVE21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZFYVE21 for disorders About GeneDecksing
OMIM gene information: 613504
OMIM disorders: --
1  disease for ZFYVE21: About MalaCardsmelanoma
Human Genome Epidemiology (HuGE) Navigator: ZFYVE21 (2 documents)
Export disorders for ZFYVE21 gene to outside databases
|
Publications
for ZFYVE21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZFYVE21 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ZFYVE21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homo logy domain. (PubMed id 21768110)1, 3 Nagano M....Seiki M. (2011)
- ZF21 protein regulates cell adhesion and motility. (PubMed id 20439989)1, 2 Nagano M....Seiki M. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center. (PubMed id 20890123)1 Nagano M....Seiki M. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Single-nucleotide polymorphisms in DNA-repair genes a nd cutaneous melanoma. (PubMed id 20601096)1 Figl A....Kumar R. (2010)
- Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
- iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. (PubMed id 12524540)1 Bergamaschi D.... Lu X. (2003)
|
External Searches for ZFYVE21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZFYVE21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZFYVE21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZFYVE21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZFYVE21 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZFYVE21 gene:
Search GeneIP for patents involving ZFYVE21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZFYVE21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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