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Aliases for ZFYVE21 Gene

Aliases for ZFYVE21 Gene

  • Zinc Finger FYVE-Type Containing 21 2 3 5
  • Zinc Finger, FYVE Domain Containing 21 2 3
  • ZF21 3 4
  • Zinc Finger FYVE Domain-Containing Protein 21 3
  • HCV P7-Transactivated Protein 1 3
  • FYVE Domain Containing 21 3
  • HCVP7TP1 3

External Ids for ZFYVE21 Gene

Previous GeneCards Identifiers for ZFYVE21 Gene

  • GC14P097997
  • GC14P102172
  • GC14P103251
  • GC14P104182
  • GC14P084360

Summaries for ZFYVE21 Gene

GeneCards Summary for ZFYVE21 Gene

ZFYVE21 (Zinc Finger FYVE-Type Containing 21) is a Protein Coding gene. Diseases associated with ZFYVE21 include Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes. An important paralog of this gene is ZFYVE16.

UniProtKB/Swiss-Prot for ZFYVE21 Gene

  • Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFYVE21 Gene

Genomics for ZFYVE21 Gene

Regulatory Elements for ZFYVE21 Gene

Enhancers for ZFYVE21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F104391 1.4 FANTOM5 Ensembl ENCODE 12.2 +677.9 677851 4.6 KLF1 PKNOX1 TAL1 ZNF175 YBX1 PLRG1 BCL11B ZNF155 CTBP1 ZFHX2 XRCC3 ZFYVE21 TRMT61A RNU6-684P GC14M104401 ENSG00000258598
GH14F103382 1.4 FANTOM5 Ensembl ENCODE 8.9 -333.0 -333030 1.0 ARID4B THRB ZNF48 RARA GLIS2 EGR2 NR2F2 ZNF341 MXD3 ZBTB33 MARK3 ZFYVE21 TNFAIP2 EIF5 RPSAP5
GH14F103627 1.1 ENCODE 11.1 -86.6 -86595 3.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FOS KLC1 XRCC3 ZFYVE21 BAG5 ENSG00000246451 APOPT1 LOC105370688 RNU4-68P
GH14F103623 1.1 Ensembl ENCODE 11 -90.4 -90428 3.0 KLF17 YY1 ZNF121 GLIS2 EGR1 ZNF366 RCOR1 ETV6 CREM SP3 KLC1 XRCC3 ZFYVE21 APOPT1 LOC105370688 RNU4-68P
GH14F103332 2.2 ENCODE 5.2 -381.4 -381372 4.7 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CDC42BPB ENSG00000259775 MARK3 CKB ZFYVE21 PIR56134 EIF5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFYVE21 on UCSC Golden Path with GeneCards custom track

Promoters for ZFYVE21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000424337 -30 2601 HDGF PKNOX1 ATF1 ARID4B SIN3A BRCA1 GLIS2 ZNF143 FOS ZNF263

Genomic Location for ZFYVE21 Gene

Chromosome:
14
Start:
103,715,730 bp from pter
End:
103,733,668 bp from pter
Size:
17,939 bases
Orientation:
Plus strand

Genomic View for ZFYVE21 Gene

Genes around ZFYVE21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFYVE21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFYVE21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFYVE21 Gene

Proteins for ZFYVE21 Gene

  • Protein details for ZFYVE21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ24-ZFY21_HUMAN
    Recommended name:
    Zinc finger FYVE domain-containing protein 21
    Protein Accession:
    Q9BQ24
    Secondary Accessions:
    • A8K3A4
    • Q86T05
    • Q96LT1

    Protein attributes for ZFYVE21 Gene

    Size:
    234 amino acids
    Molecular mass:
    26506 Da
    Quaternary structure:
    • Interacts with PTK2/FAK1.
    SequenceCaution:
    • Sequence=CAD62589.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZFYVE21 Gene

    Alternative splice isoforms for ZFYVE21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFYVE21 Gene

Post-translational modifications for ZFYVE21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFYVE21 Gene

No data available for DME Specific Peptides for ZFYVE21 Gene

Domains & Families for ZFYVE21 Gene

Gene Families for ZFYVE21 Gene

Protein Domains for ZFYVE21 Gene

Suggested Antigen Peptide Sequences for ZFYVE21 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BQ24

UniProtKB/Swiss-Prot:

ZFY21_HUMAN :
  • The FYVE-type zinc finger mediates interaction with PTK2/FAK1, and also interaction with PI(3)P and association with endosomes.
  • Contains 1 FYVE-type zinc finger.
Domain:
  • The FYVE-type zinc finger mediates interaction with PTK2/FAK1, and also interaction with PI(3)P and association with endosomes.
  • The C-terminal region exhibits a structure similar to canonical PH domains, but lacks a positively charged interface to bind phosphatidylinositol phosphate.
Similarity:
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with ZFYVE21: view

Function for ZFYVE21 Gene

Molecular function for ZFYVE21 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression.

Gene Ontology (GO) - Molecular Function for ZFYVE21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0044183 NOT protein binding involved in protein folding IBA --
GO:0046872 metal ion binding IEA --
GO:0051082 NOT unfolded protein binding IBA --
genes like me logo Genes that share ontologies with ZFYVE21: view
genes like me logo Genes that share phenotypes with ZFYVE21: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFYVE21 Gene

Localization for ZFYVE21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFYVE21 Gene

Cell junction, focal adhesion. Cytoplasmic vesicle. Endosome. Note=Within cytoplasmic vesicles, partially colocalizes with EEA1, an endosomal marker.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFYVE21 gene
Compartment Confidence
endosome 5
cytosol 4
extracellular 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ZFYVE21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005829 cytosol IEA --
GO:0005925 focal adhesion IEA --
GO:0010008 endosome membrane IBA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with ZFYVE21: view

Pathways & Interactions for ZFYVE21 Gene

SuperPathways for ZFYVE21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFYVE21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006458 NOT de novo protein folding IBA --
GO:0042147 retrograde transport, endosome to Golgi IBA --
GO:0046854 phosphatidylinositol phosphorylation IBA --
GO:0061077 NOT chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with ZFYVE21: view

No data available for Pathways by source and SIGNOR curated interactions for ZFYVE21 Gene

Transcripts for ZFYVE21 Gene

Unigene Clusters for ZFYVE21 Gene

Zinc finger, FYVE domain containing 21:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE21 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - -
SP6: - -
SP7: - -
SP8:

Relevant External Links for ZFYVE21 Gene

GeneLoc Exon Structure for
ZFYVE21
ECgene alternative splicing isoforms for
ZFYVE21

Expression for ZFYVE21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFYVE21 Gene

Protein differential expression in normal tissues from HIPED for ZFYVE21 Gene

This gene is overexpressed in Heart (45.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFYVE21 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZFYVE21 Gene:

ZFYVE21

SOURCE GeneReport for Unigene cluster for ZFYVE21 Gene:

Hs.592322
genes like me logo Genes that share expression patterns with ZFYVE21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZFYVE21 Gene

Orthologs for ZFYVE21 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFYVE21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFYVE21 34 35
  • 97.62 (n)
dog
(Canis familiaris)
Mammalia ZFYVE21 34 35
  • 88.36 (n)
mouse
(Mus musculus)
Mammalia Zfyve21 34 16 35
  • 83.9 (n)
rat
(Rattus norvegicus)
Mammalia Zfyve21 34
  • 83.71 (n)
cow
(Bos Taurus)
Mammalia ZFYVE21 34 35
  • 81.87 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFYVE21 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFYVE21 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFYVE21 34 35
  • 76.5 (n)
lizard
(Anolis carolinensis)
Reptilia ZFYVE21 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfyve21 34
  • 70.29 (n)
Str.904 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24182 34
zebrafish
(Danio rerio)
Actinopterygii zfyve21 34 35
  • 69.76 (n)
wufb66b01 34
fruit fly
(Drosophila melanogaster)
Insecta Sara 35
  • 4 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea aka-1 35
  • 5 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAB1 35
  • 2 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4065 35
  • 4 (a)
OneToMany
Species where no ortholog for ZFYVE21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFYVE21 Gene

ENSEMBL:
Gene Tree for ZFYVE21 (if available)
TreeFam:
Gene Tree for ZFYVE21 (if available)

Paralogs for ZFYVE21 Gene

Paralogs for ZFYVE21 Gene

genes like me logo Genes that share paralogs with ZFYVE21: view

Variants for ZFYVE21 Gene

Sequence variations from dbSNP and Humsavar for ZFYVE21 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10138768 -- 103,724,190(+) ACCCC(A/G)GCTCA intron-variant
rs10143623 -- 103,720,539(+) GTCCA(A/G)CCTGT intron-variant
rs10150588 -- 103,730,929(+) GAGCC(C/T)AGGCA intron-variant
rs1058080 -- 103,733,414(+) GGCTT(C/T)TGGTC downstream-variant-500B, utr-variant-3-prime
rs111228955 -- 103,724,177(+) CCGCG(C/T)GGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFYVE21 Gene

Variant ID Type Subtype PubMed ID
esv2760013 CNV loss 17122850
nsv1054574 CNV loss 25217958
nsv1131077 CNV deletion 24896259
nsv470673 CNV loss 18288195
nsv527425 CNV loss 19592680
nsv566023 CNV loss 21841781
nsv827071 CNV gain 20364138
nsv9171 CNV gain 18304495
nsv952260 CNV deletion 24416366

Variation tolerance for ZFYVE21 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFYVE21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFYVE21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFYVE21 Gene

Disorders for ZFYVE21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFYVE21 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZFYVE21

Genetic Association Database (GAD)
ZFYVE21
Human Genome Epidemiology (HuGE) Navigator
ZFYVE21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFYVE21
genes like me logo Genes that share disorders with ZFYVE21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFYVE21 Gene

Publications for ZFYVE21 Gene

  1. ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain. (PMID: 21768110) Nagano M. … Seiki M. (J. Biol. Chem. 2011) 2 3 4 64
  2. ZF21 protein regulates cell adhesion and motility. (PMID: 20439989) Nagano M. … Seiki M. (J. Biol. Chem. 2010) 3 4 64
  3. Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma. (PMID: 20601096) Figl A. … Kumar R. (Mutat. Res. 2010) 3 46 64
  4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ZFYVE21 Gene

Sources for ZFYVE21 Gene

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