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ZFYVE20 Gene

protein-coding   GIFtS: 58
GCID: GC03M015111

Zinc Finger, FYVE Domain Containing 20

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, FYVE Domain Containing 201 2     Rabenosyn-52
Zinc Finger FYVE Domain-Containing Protein 202 3     FYVE-Finger-Containing Rab5 Effector Protein Rabenosyn-52
110 KDa Protein2 3     rabenosyn-52
FYVE Finger-Containing Rab5 Effector Protein Rabenosyn-52 3     

External Ids:    HGNC: 207591   Entrez Gene: 641452   Ensembl: ENSG000001313817   OMIM: 6095115   UniProtKB: Q9H1K03   

Export aliases for ZFYVE20 gene to outside databases

Previous GC identifers: GC03M015051 GC03M015086 GC03M015090


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZFYVE20 Gene:
ZFYVE20 (zinc finger, FYVE domain containing 20) is a protein-coding gene. GO annotations related to this gene include Rab GTPase binding.

UniProtKB/Swiss-Prot: RBNS5_HUMAN, Q9H1K0
Function: Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of
recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a
role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of
transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing
phosphatidylinositol 3-phosphate (PtdInsP3)

Gene Wiki entry for ZFYVE20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFYVE20 gene promoter:
         Tal-1   RREB-1   FOXO3   HNF-4alpha2   E4BP4   FOXO3b   E47   HNF-4alpha1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZFYVE20 promoter sequence
   Search Chromatin IP Primers for ZFYVE20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFYVE20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25.1

ZFYVE20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFYVE20 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M015111:  view genomic region     (about GC identifiers)

Start:
15,111,580 bp from pter      End:
15,140,670 bp from pter
Size:
29,091 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RBNS5_HUMAN, Q9H1K0 (See protein sequence)
Recommended Name: Rabenosyn-5  
Size: 784 amino acids; 88870 Da
Subunit: Interacts with EHD1, RAB4A, RAB5A, RAB14, RAB22A, RAB24 and VPS45. Binds simultaneously to RAB4A and
RAB5A in vitro. Interacts with RAB4A and RAB5A that has been activated by GTP binding
Sequence caution: Sequence=BAC03860.1; Type=Erroneous initiation; Sequence=BAD92910.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for ZFYVE20:
1YZM (3D)        1Z0J (3D)        1Z0K (3D)    
Secondary accessions: Q3KP30 Q59EY8 Q8NAQ1

Explore the universe of human proteins at neXtProt for ZFYVE20: NX_Q9H1K0

Explore proteomics data for ZFYVE20 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZFYVE20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071735.2  
    ENSEMBL proteins: 
     ENSP00000253699   ENSP00000422551   ENSP00000403368   ENSP00000414020   ENSP00000387724  
     ENSP00000427038   ENSP00000391039  
    Reactome Protein details: Q9H1K0

    ZFYVE20 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZFYVE20

     
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    antibodies-online proteins for ZFYVE20 (2 products) 

     
    antibodies-online peptides for ZFYVE20

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    ZFYVE20 Assay Products:

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    antibodies-online kits for ZFYVE20 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFYVE: Zinc fingers, FYVE domain containing

    Selected InterPro protein domains (see all 7):
     IPR000306 Znf_FYVE
     IPR013083 Znf_RING/FYVE/PHD
     IPR015880 Znf_C2H2-like
     IPR017455 Znf_FYVE-rel
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H1K0

    ProtoNet protein and cluster: Q9H1K0

    1 Blocks protein domain: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: RBNS5_HUMAN, Q9H1K0
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 1 UIM (ubiquitin-interacting motif) repeat


    Find genes that share domains with ZFYVE20           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBNS5_HUMAN, Q9H1K0
    Function: Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of
    recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a
    role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of
    transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing
    phosphatidylinositol 3-phosphate (PtdInsP3)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15020713
    GO:0008270zinc ion binding NAS11062261
    GO:0017137Rab GTPase binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with ZFYVE20           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Zfyve20):
     mortality/aging 

    Find genes that share phenotypes with ZFYVE20           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZFYVE20

    miRNA
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    miRTarBase miRNAs that target ZFYVE20:
    hsa-mir-22-3p (MIRT030636), hsa-mir-92a-3p (MIRT049486), hsa-mir-222-3p (MIRT046649), hsa-mir-423-3p (MIRT042592), hsa-mir-30b-5p (MIRT023416), hsa-mir-33a-5p (MIRT028206), hsa-mir-7-5p (MIRT025703)

    Block miRNA regulation of human, mouse, rat ZFYVE20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFYVE20 (see all 59):
    hsa-miR-142-5p hsa-miR-345 hsa-miR-3607-3p hsa-miR-300 hsa-miR-429 hsa-miR-4272 hsa-miR-875-5p hsa-miR-106a
    SwitchGear 3'UTR luciferase reporter plasmidZFYVE20 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZFYVE20

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ZFYVE20 (NM_022340)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFYVE20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFYVE20
    Addgene plasmids for ZFYVE20 

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    eBioscience FlowRNA Probe Sets ( VA1-11995) for ZFYVE20 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RBNS5_HUMAN, Q9H1K0: Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    nucleus3
    cytosol2
    chloroplast1
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome NAS11062261
    GO:0005886plasma membrane IEA--
    GO:0010008endosome membrane TAS--
    GO:0031901early endosome membrane IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with ZFYVE20           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZFYVE20 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Delta508 CFTR traffic Sorting endosome formation in CF
    Normal wtCFTR traffic Sorting endosome formation0.00
    Delta508 CFTR traffic Sorting endosome formation in CF
    2Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    3Clathrin dependent protein traffic
    Transport Clathrin coated vesicle cycle0.66
    4Hemostasis
    Hemostasis0.43
    5Regulation of CFTR activity norm and CF
    wtCFTR and deltaF508 traffic Membrane expression norm and CF 0.38


    Find genes that share SuperPaths with ZFYVE20           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 GeneGo (Thomson Reuters) Pathways for ZFYVE20
        Normal wtCFTR traffic / Sorting endosome formation
    Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    Delta508-CFTR traffic / Sorting endosome formation in CF
    Transport Clathrin-coated vesicle cycle

    1 Reactome Pathway for ZFYVE20
        Factors involved in megakaryocyte development and platelet production


    1 Kegg Pathway  (Kegg details for ZFYVE20):
        Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFYVE20
    Interactions:

        GeneGlobe Interaction Network for ZFYVE20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZFYVE20 (Q9H1K02, 3 ENSP000002536994) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DTNBP1Q96EV83, ENSP000003416804I2D: score=2 STRING: ENSP00000341680
    EHD1Q9H4M93, ENSP000003205164I2D: score=1 STRING: ENSP00000320516
    RAB14P611063, ENSP000003629464I2D: score=1 STRING: ENSP00000362946
    RAB5CP511483, ENSP000003456894I2D: score=1 STRING: ENSP00000345689
    RAB4AP203383, ENSP000003556514I2D: score=2 STRING: ENSP00000355651
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation TAS--
    GO:0015031protein transport IEA--
    GO:0016197endosomal transport NAS11062261

    Find genes that share ontologies with ZFYVE20           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFYVE20 (RBNS5)

    1 HMDB Compound for ZFYVE20    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZFYVE20 gene: 
    NM_022340.2  

    Unigene Cluster for ZFYVE20:

    Zinc finger, FYVE domain containing 20
    Hs.475565  [show with all ESTs]
    Unigene Representative Sequence: AL833545
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253699(uc003bzm.1 uc010hek.1) ENST00000476527 ENST00000426541
    ENST00000483098 ENST00000449964 ENST00000463214 ENST00000441057 ENST00000449050
    ENST00000507357 ENST00000435849(uc011avn.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZFYVE20 (see all 59):
    hsa-miR-142-5p hsa-miR-345 hsa-miR-3607-3p hsa-miR-300 hsa-miR-429 hsa-miR-4272 hsa-miR-875-5p hsa-miR-106a
    SwitchGear 3'UTR luciferase reporter plasmidZFYVE20 3' UTR sequence
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-11995) for ZFYVE20 

    Additional mRNA sequence: 

    AB209673.1 AK054598.1 AK291288.1 AK301735.1 AL833545.1 AY009133.1 BC032628.1 BC106940.2 
    BX640925.1 

    11 DOTS entries:

    DT.412430  DT.100780824  DT.97773409  DT.75127166  DT.100780822  DT.309299  DT.86844089  DT.100780825 
    DT.95162801  DT.100780826  DT.120856605 

    Selected AceView cDNA sequences (see all 123):

    AW449780 BM684196 AI435608 AI804938 BF446469 AI420147 BX473970 BM719351 
    AW629629 BM727783 BM679158 AI478295 AA495928 CA413514 BX640925 BQ423134 
    BP359638 AA340962 AW452275 BM719702 BM561294 BM674859 AL598044 BQ180899 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE20 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^
    SP1:                                                              -     -                       -           -                                                   
    SP2:                                                              -     -                       -                                                               
    SP3:                    -                                         -                                                                                             
    SP4:                    -     -                                   -     -                       -                                                               
    SP5:                                                                                                                                                            

    ExUns: 14 ^ 15 ^ 16
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for ZFYVE20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFYVE20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTACTCTG
    ZFYVE20 Expression
    About this image

    ZFYVE20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFYVE20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.475565
        Custom PCR Arrays for ZFYVE20
    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFYVE20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZFYVE20 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfyve201 , 5 zinc finger, FYVE domain containing 201, 5 84.62(n)1
    85.18(a)1
      6 (41.03 cM)5
    782871  NM_030081.21  NP_084357.21 
     921867125 
    chicken
    (Gallus gallus)
    Aves ZFYVE201 zinc finger, FYVE domain containing 20 69.04(n)
    70.62(a)
      416128  XM_414460.4  XP_414460.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZFYVE206
    zinc finger, FYVE domain containing 20
    68(a)
    1 ↔ 1
    2(170859109-170877868)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.125122 Xenopus laevis transcribed sequence with moderate similarity more 75.3(n)    BJ070322.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5692401 rabenosyn-5-like 61.58(n)
    59.97(a)
      569240  XM_005167358.1  XP_005167415.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rbsn-51 Rabenosyn-5 46.73(n)
    35.27(a)
      34110  NM_135342.5  NP_609186.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rabs-51 rabs-5 43.7(n)
    33.82(a)
      177603  NM_068951.3  NP_501352.1 


    ENSEMBL Gene Tree for ZFYVE20 (if available)
    TreeFam Gene Tree for ZFYVE20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZFYVE20 gene
    1 SIMAP similar gene for ZFYVE20 using alignment to 6 protein entries:     RBNS5_HUMAN (see all proteins):
    DKFZp686N01252

    Find genes that share paralogs with ZFYVE20           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFYVE20 (see all 703)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2013712381,2
    C--15111103(-) GCCACA/CCAGCC 1 -- ds50010--------
    rs1918253921,2
    --15111181(+) CACAGG/TCATGC 1 -- ds50010--------
    rs1181271881,2
    C,F--15111218(+) GTCATG/ACAGAG 1 -- ds50011Minor allele frequency- A:0.06EA 120
    rs1407717531,2
    C--15111367(+) CAGGAA/GTAACT 1 -- ds50010--------
    rs622404021,2
    C,F--15111397(+) GAACCC/TGTATC 1 -- ds500110Minor allele frequency- T:0.17NA CSA WA EA 372
    rs1430975151,2
    --15111534(+) TGATGA/GTTCTC 1 -- ds50010--------
    rs38322161,2
    C--15111596(-) AAAAA-/ATAAAA 1 -- ut310--------
    rs755010721,2
    C--15111706(+) GTCTGC/TGACCT 1 -- ut310--------
    rs1843218171,2
    --15112044(+) CTAAAA/GAAAGG 1 -- ut310--------
    rs1880598501,2
    --15112097(+) ATACAC/TAGGCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZFYVE20 (15111580 - 15140670 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZFYVE20:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834620CNV Gain17160897
    nsv428413CNV Gain18775914
    dgv1436e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFYVE20
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFYVE20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609511    OMIM disorders: --


    Find genes that share disorders with ZFYVE20           About GenesLikeMe


    Export disorders for ZFYVE20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFYVE20 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with ZFYVE20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. (PubMed id 11062261)1, 2, 3 Nielsen E.... Zerial M. (J. Cell Biol. 2000)
    2. Structural basis of family-wide Rab GTPase recognition by rabenosyn- 5. (PubMed id 16034420)1, 2 Eathiraj S.... Lambright D.G. (Nature 2005)
    3. Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane. (PubMed id 15020713)1, 2 Naslavsky N.... Caplan S. (Mol. Biol. Cell 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes. (PubMed id 11788822)1, 2 de Renzis S.... Zerial M. (Nat. Cell Biol. 2002)
    7. Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (PubMed id 22488850)1 Zuo L....Luo X. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis. (PubMed id 22308388)1 Navaroli D.M....Corvera S. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Common and distinct roles for the binding partners Rabenosyn-5 and Vps45 in the regulation of endocytic trafficking in mammalian cells. (PubMed id 19931244)1 Rahajeng J....Naslavsky N. (Exp. Cell Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64145 HGNC: 20759 AceView: ZFYVE20 Ensembl:ENSG00000131381 euGenes: HUgn64145
    ECgene: ZFYVE20 Kegg: 64145 H-InvDB: ZFYVE20

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZFYVE20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZFYVE20 gene:
    Search GeneIP for patents involving ZFYVE20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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