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Aliases for ZFYVE19 Gene

Aliases for ZFYVE19 Gene

  • Zinc Finger, FYVE Domain Containing 19 2 3
  • Zinc Finger FYVE Domain-Containing Protein 19 3 4
  • MLL Partner Containing FYVE Domain 3 4
  • MPFYVE 3 4
  • ANCHR 3 4
  • Abscission/Nocut Checkpoint Regulator 2
  • Abscission/NoCut Checkpoint Regulator 3

External Ids for ZFYVE19 Gene

Summaries for ZFYVE19 Gene

GeneCards Summary for ZFYVE19 Gene

ZFYVE19 (Zinc Finger, FYVE Domain Containing 19) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZFYVE19 Gene

  • Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.

Gene Wiki entry for ZFYVE19 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFYVE19 Gene

Genomics for ZFYVE19 Gene

Genomic Location for ZFYVE19 Gene

Start:
40,807,076 bp from pter
End:
40,815,084 bp from pter
Size:
8,009 bases
Orientation:
Plus strand

Genomic View for ZFYVE19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFYVE19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFYVE19 Gene

Regulatory Elements for ZFYVE19 Gene

Proteins for ZFYVE19 Gene

  • Protein details for ZFYVE19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K21-ANCHR_HUMAN
    Recommended name:
    Abscission/NoCut checkpoint regulator
    Protein Accession:
    Q96K21
    Secondary Accessions:
    • B3KVB2
    • C9JNF4
    • H3BUF9
    • Q86WC2
    • Q8WU96

    Protein attributes for ZFYVE19 Gene

    Size:
    471 amino acids
    Molecular mass:
    51546 Da
    Quaternary structure:
    • Interacts (via MIM1-B) with VPS4A; interaction takes place at the midbody ring following cytokinesis checkpoint activation.
    SequenceCaution:
    • Sequence=AAH21092.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO73862.1; Type=Frameshift; Positions=459; Evidence={ECO:0000305}; Sequence=BAB55338.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFYVE19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFYVE19 Gene

Proteomics data for ZFYVE19 Gene at MOPED

Post-translational modifications for ZFYVE19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFYVE19 Gene

Domains for ZFYVE19 Gene

Gene Families for ZFYVE19 Gene

HGNC:
  • ZFYVE :Zinc fingers, FYVE domain containing

Protein Domains for ZFYVE19 Gene

UniProtKB/Swiss-Prot:

ANCHR_HUMAN
Domain:
  • The FYVE-type zinc finger mediates binding to phosphatidylinositol-3-phosphate (PtdIns(3)P).:
    • Q96K21
  • The MIM1-B motif mediates interaction with VPS4A.:
    • Q96K21
Similarity:
  • Contains 1 FYVE-type zinc finger.:
    • Q96K21
genes like me logo Genes that share domains with ZFYVE19: view

Function for ZFYVE19 Gene

Molecular function for ZFYVE19 Gene

UniProtKB/Swiss-Prot Function: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.

Gene Ontology (GO) - Molecular Function for ZFYVE19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17500595
GO:0008270 zinc ion binding IEA --
GO:0032266 phosphatidylinositol-3-phosphate binding IDA 24814515
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZFYVE19: view

Phenotypes for ZFYVE19 Gene

GenomeRNAi human phenotypes for ZFYVE19:
genes like me logo Genes that share phenotypes with ZFYVE19: view

miRNA for ZFYVE19 Gene

miRTarBase miRNAs that target ZFYVE19

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFYVE19 Gene

Localization for ZFYVE19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFYVE19 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis (PubMed:24814515). {ECO:0000269 PubMed:24814515}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFYVE19 Gene COMPARTMENTS Subcellular localization image for ZFYVE19 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for ZFYVE19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 24814515
GO:0030496 midbody IDA 24814515
GO:0032154 cleavage furrow IDA 24814515
genes like me logo Genes that share ontologies with ZFYVE19: view

Pathways for ZFYVE19 Gene

SuperPathways for ZFYVE19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFYVE19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0009838 abscission IMP 24814515
GO:0031565 obsolete cytokinesis checkpoint --
GO:0032466 negative regulation of cytokinesis IMP 24814515
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ZFYVE19: view

No data available for Pathways by source for ZFYVE19 Gene

Transcripts for ZFYVE19 Gene

Unigene Clusters for ZFYVE19 Gene

Zinc finger, FYVE domain containing 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE19 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: -
SP8: - - -
SP9:
SP10:
SP11:
SP12: - - -
SP13:

ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:

Relevant External Links for ZFYVE19 Gene

GeneLoc Exon Structure for
ZFYVE19
ECgene alternative splicing isoforms for
ZFYVE19

Expression for ZFYVE19 Gene

mRNA expression in normal human tissues for ZFYVE19 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFYVE19 Gene

SOURCE GeneReport for Unigene cluster for ZFYVE19 Gene Hs.121676

mRNA Expression by UniProt/SwissProt for ZFYVE19 Gene

Q96K21-ANCHR_HUMAN
Tissue specificity: Detected in brain, heart, skeletal muscle, kidney and liver.
genes like me logo Genes that share expressions with ZFYVE19: view

Orthologs for ZFYVE19 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFYVE19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFYVE19 36
  • 99.07 (n)
  • 98.99 (a)
ZFYVE19 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFYVE19 36
  • 85.19 (n)
  • 82.83 (a)
ZFYVE19 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFYVE19 36
  • 86.7 (n)
  • 86.11 (a)
ZFYVE19 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfyve19 36
  • 82.52 (n)
  • 81.65 (a)
Zfyve19 16
Zfyve19 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFYVE19 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFYVE19 37
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfyve19 36
  • 80.57 (n)
  • 78.5 (a)
chicken
(Gallus gallus)
Aves ZFYVE19 36
  • 63.67 (n)
  • 63.75 (a)
ZFYVE19 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFYVE19 37
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfyve19 36
  • 59.54 (n)
  • 57.99 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.6184 36
zfyve19 36
  • 60.56 (n)
  • 54.71 (a)
zfyve19 37
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002064 36
  • 47.98 (n)
  • 39.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15602 36
  • 45.49 (n)
  • 37.46 (a)
CG15602 37
  • 29 (a)
OneToOne
Species with no ortholog for ZFYVE19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFYVE19 Gene

ENSEMBL:
Gene Tree for ZFYVE19 (if available)
TreeFam:
Gene Tree for ZFYVE19 (if available)

Paralogs for ZFYVE19 Gene

No data available for Paralogs for ZFYVE19 Gene

Variants for ZFYVE19 Gene

Sequence variations from dbSNP and Humsavar for ZFYVE19 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs7915 -- 40,814,287(+) GGCCC(A/C)GCCAC utr-variant-3-prime
rs14385 -- 40,814,279(+) CATTT(C/T)TGGGC utr-variant-3-prime
rs604250 -- 40,812,990(+) TGCGC(C/T)CAGAG intron-variant
rs690269 -- 40,811,542(+) gagaa(A/G)tcctg intron-variant
rs690347 - 40,813,728(+) AAGCT(G/T)CCCTG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ZFYVE19 Gene

Variant ID Type Subtype PubMed ID
nsv904101 CNV Loss 21882294
nsv904102 CNV Loss 21882294
esv272589 CNV Insertion 20981092
esv267815 CNV Insertion 20981092

Relevant External Links for ZFYVE19 Gene

HapMap Linkage Disequilibrium report
ZFYVE19

Disorders for ZFYVE19 Gene

UniProtKB/Swiss-Prot

ANCHR_HUMAN
  • Note=A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with KMT2A/MLL1 (PubMed:12618766). {ECO:0000269 PubMed:12618766}.

No disorders were found for ZFYVE19 Gene.

Publications for ZFYVE19 Gene

  1. ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4. (PMID: 24814515) Thoresen S.B. … Stenmark H. (Nat. Cell Biol. 2014) 2 3 4
  2. A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15. (PMID: 12618766) Chinwalla V. … Rowley J.D. (Oncogene 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ZFYVE19 Gene

Sources for ZFYVE19 Gene

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