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Aliases for ZFYVE19 Gene

Aliases for ZFYVE19 Gene

  • Zinc Finger FYVE-Type Containing 19 2 3 5
  • Zinc Finger FYVE Domain-Containing Protein 19 3 4
  • Zinc Finger, FYVE Domain Containing 19 2 3
  • MLL Partner Containing FYVE Domain 3 4
  • MPFYVE 3 4
  • ANCHR 3 4
  • Abscission/Nocut Checkpoint Regulator 2
  • Abscission/NoCut Checkpoint Regulator 3

External Ids for ZFYVE19 Gene

Previous GeneCards Identifiers for ZFYVE19 Gene

  • GC15P033995
  • GC15P038678
  • GC15P038815
  • GC15P038886
  • GC15P041099
  • GC15P017947

Summaries for ZFYVE19 Gene

GeneCards Summary for ZFYVE19 Gene

ZFYVE19 (Zinc Finger FYVE-Type Containing 19) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol-3-phosphate binding.

UniProtKB/Swiss-Prot for ZFYVE19 Gene

  • Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.

Gene Wiki entry for ZFYVE19 Gene

Additional gene information for ZFYVE19 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFYVE19 Gene

Genomics for ZFYVE19 Gene

Regulatory Elements for ZFYVE19 Gene

Enhancers for ZFYVE19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H040806 1.1 ENCODE 41.9 +0.6 565 2 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF207 ZNF143 DEK ZFYVE19 CHP1 DNAJC17 GC15P040859
GH15H040762 1.4 ENCODE dbSUPER 32.7 -42.4 -42428 4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 ZNF207 MGA ZFYVE19 ENSG00000259211 CCDC32 DNAJC17 INO80 RAD51-AS1 FAM92A1P1 BAHD1 EIF2AK4
GH15H040791 1.5 Ensembl ENCODE dbSUPER 25.8 -12.6 -12639 5 FOXA2 ARID4B FEZF1 BRCA1 YY1 FOS REST MIER2 PPARG KAT8 ZFYVE19 RMDN3 CCDC32 C15orf62 SPINT1 GCHFR RAD51 RAD51-AS1 RHOV RPUSD2
GH15H040823 1 ENCODE 32.6 +18.1 18104 3 PKNOX1 FOXA2 ARNT TCF12 ZNF766 GATA2 FOS ATF7 NCOA1 MEF2D ZFYVE19 CHP1 PIR57888 PPP1R14D
GH15H040785 1.3 Ensembl ENCODE dbSUPER 24.3 -19.6 -19563 4 CTCF NFIB ZIC2 RAD21 CTBP1 GATA3 POLR2A FOS PRDM10 RUNX3 ZFYVE19 CCDC32 RMDN3 GCHFR SPINT1 RAD51-AS1 RAD51 RHOV VPS18 ENSG00000251161
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFYVE19 on UCSC Golden Path with GeneCards custom track

Promoters for ZFYVE19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075564 424 1401 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF207 ZNF143 DEK

Genomic Location for ZFYVE19 Gene

Chromosome:
15
Start:
40,807,076 bp from pter
End:
40,815,084 bp from pter
Size:
8,009 bases
Orientation:
Plus strand

Genomic View for ZFYVE19 Gene

Genes around ZFYVE19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFYVE19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFYVE19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFYVE19 Gene

Proteins for ZFYVE19 Gene

  • Protein details for ZFYVE19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K21-ANCHR_HUMAN
    Recommended name:
    Abscission/NoCut checkpoint regulator
    Protein Accession:
    Q96K21
    Secondary Accessions:
    • B3KVB2
    • C9JNF4
    • H3BUF9
    • Q86WC2
    • Q8WU96

    Protein attributes for ZFYVE19 Gene

    Size:
    471 amino acids
    Molecular mass:
    51546 Da
    Quaternary structure:
    • Interacts (via MIM1-B) with VPS4A; interaction takes place at the midbody ring following cytokinesis checkpoint activation.
    SequenceCaution:
    • Sequence=AAH21092.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO73862.1; Type=Frameshift; Positions=459; Evidence={ECO:0000305}; Sequence=BAB55338.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFYVE19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFYVE19 Gene

Post-translational modifications for ZFYVE19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFYVE19 Gene

Domains & Families for ZFYVE19 Gene

Gene Families for ZFYVE19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for ZFYVE19 Gene

Graphical View of Domain Structure for InterPro Entry

Q96K21

UniProtKB/Swiss-Prot:

ANCHR_HUMAN :
  • The FYVE-type zinc finger mediates binding to phosphatidylinositol-3-phosphate (PtdIns(3)P).
Domain:
  • The FYVE-type zinc finger mediates binding to phosphatidylinositol-3-phosphate (PtdIns(3)P).
  • The MIM1-B motif mediates interaction with VPS4A.
genes like me logo Genes that share domains with ZFYVE19: view

Function for ZFYVE19 Gene

Molecular function for ZFYVE19 Gene

UniProtKB/Swiss-Prot Function:
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.

Phenotypes From GWAS Catalog for ZFYVE19 Gene

Gene Ontology (GO) - Molecular Function for ZFYVE19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17500595
GO:0008289 lipid binding IEA --
GO:0032266 phosphatidylinositol-3-phosphate binding IDA 24814515
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFYVE19: view
genes like me logo Genes that share phenotypes with ZFYVE19: view

Animal Model Products

CRISPR Products

miRNA for ZFYVE19 Gene

miRTarBase miRNAs that target ZFYVE19

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZFYVE19
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFYVE19 Gene

Localization for ZFYVE19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFYVE19 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody, Midbody ring. Note=Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis. {ECO:0000269 PubMed:24814515}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFYVE19 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for ZFYVE19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 24814515
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0030496 midbody IEA,IDA 24814515
genes like me logo Genes that share ontologies with ZFYVE19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZFYVE19 Gene

Pathways & Interactions for ZFYVE19 Gene

SuperPathways for ZFYVE19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFYVE19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0009838 abscission IMP 24814515
GO:0032466 negative regulation of cytokinesis IMP 24814515
GO:0044878 mitotic cytokinesis checkpoint IMP 24814515
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ZFYVE19: view

No data available for Pathways by source and SIGNOR curated interactions for ZFYVE19 Gene

Drugs & Compounds for ZFYVE19 Gene

No Compound Related Data Available

Transcripts for ZFYVE19 Gene

Unigene Clusters for ZFYVE19 Gene

Zinc finger, FYVE domain containing 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZFYVE19
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE19 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
SP1: - - - - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: -
SP8: - - -
SP9:
SP10:
SP11:
SP12: - - -
SP13:

ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:

Relevant External Links for ZFYVE19 Gene

GeneLoc Exon Structure for
ZFYVE19
ECgene alternative splicing isoforms for
ZFYVE19

Expression for ZFYVE19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFYVE19 Gene

Protein differential expression in normal tissues from HIPED for ZFYVE19 Gene

This gene is overexpressed in Adrenal (27.9) and Peripheral blood mononuclear cells (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFYVE19 Gene



Protein tissue co-expression partners for ZFYVE19 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFYVE19 Gene:

ZFYVE19

SOURCE GeneReport for Unigene cluster for ZFYVE19 Gene:

Hs.121676

mRNA Expression by UniProt/SwissProt for ZFYVE19 Gene:

Q96K21-ANCHR_HUMAN
Tissue specificity: Detected in brain, heart, skeletal muscle, kidney and liver.

Evidence on tissue expression from TISSUES for ZFYVE19 Gene

  • Lung(4.3)
  • Liver(4.2)
  • Blood(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with ZFYVE19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFYVE19 Gene

Orthologs for ZFYVE19 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFYVE19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFYVE19 33 34
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia ZFYVE19 33 34
  • 86.7 (n)
cow
(Bos Taurus)
Mammalia ZFYVE19 33 34
  • 85.19 (n)
mouse
(Mus musculus)
Mammalia Zfyve19 33 16 34
  • 82.52 (n)
rat
(Rattus norvegicus)
Mammalia Zfyve19 33
  • 80.57 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFYVE19 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFYVE19 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFYVE19 33 34
  • 63.67 (n)
lizard
(Anolis carolinensis)
Reptilia ZFYVE19 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfyve19 33
  • 59.54 (n)
zebrafish
(Danio rerio)
Actinopterygii zfyve19 33 34
  • 60.56 (n)
Dr.6184 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002064 33
  • 47.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15602 33 34
  • 45.49 (n)
Species where no ortholog for ZFYVE19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFYVE19 Gene

ENSEMBL:
Gene Tree for ZFYVE19 (if available)
TreeFam:
Gene Tree for ZFYVE19 (if available)

Paralogs for ZFYVE19 Gene

No data available for Paralogs for ZFYVE19 Gene

Variants for ZFYVE19 Gene

Sequence variations from dbSNP and Humsavar for ZFYVE19 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000592597 -- 40,813,181(+) GCAGG(C/G)AGGGA intron-variant
rs1000936706 -- 40,807,270(+) GACCC(A/G)AATGA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001595906 -- 40,814,359(+) CTTGG(C/T)GTCCC utr-variant-3-prime
rs1002161752 -- 40,808,619(+) ATTAA(A/G)TAAAA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1002498243 -- 40,812,967(+) CTGAG(A/T)CAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFYVE19 Gene

Variant ID Type Subtype PubMed ID
esv3303536 CNV mobile element insertion 20981092
esv3308315 CNV mobile element insertion 20981092
esv3341129 CNV insertion 20981092
esv3377638 CNV insertion 20981092
esv3420172 CNV insertion 20981092
nsv1054764 CNV gain 25217958
nsv569228 CNV loss 21841781

Variation tolerance for ZFYVE19 Gene

Residual Variation Intolerance Score: 64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.68; 91.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFYVE19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFYVE19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFYVE19 Gene

Disorders for ZFYVE19 Gene

UniProtKB/Swiss-Prot

ANCHR_HUMAN
  • Note=A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with KMT2A/MLL1 (PubMed:12618766). {ECO:0000269 PubMed:12618766}.

Relevant External Links for ZFYVE19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFYVE19

No disorders were found for ZFYVE19 Gene.

No data available for MalaCards and Genatlas for ZFYVE19 Gene

Publications for ZFYVE19 Gene

  1. ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4. (PMID: 24814515) Thoresen SB … Stenmark H (Nature cell biology 2014) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15. (PMID: 12618766) Chinwalla V … Rowley JD (Oncogene 2003) 3 4 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for ZFYVE19 Gene

Sources for ZFYVE19 Gene

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