ZFYVE19 Gene
protein-coding GIFtS: 43
GCID: GC15P041099
|
|
zinc finger, FYVE domain containing 19
| |
Aliases
for ZFYVE19 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, FYVE Domain Containing 191 2 | | MPFYVE2 3 | | MLL Partner Containing FYVE Domain2 3 | | FLJ148401 | | Zinc Finger FYVE Domain-Containing Protein 192 |
Export aliases for ZFYVE19 gene to outside databasesPrevious GC identifers: GC15P033995 GC15P038678 GC15P038815 GC15P038886 GC15P017947 |
Summaries
for ZFYVE19 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for ZFYVE19
|
Genomic Views
for ZFYVE19 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZFYVE19 gene promoter:
Bach1 AhR Max1 Nkx2-5 PPAR-gamma1 IRF-7A PPAR-gamma2 ATF6 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZFYVE19
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFYVE19 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15.1 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q14ZFYVE19 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P041099: view genomic region
(about GC identifiers)
Start:
|
41,099,274 bp from pter |
End:
|
41,106,767 bp from pter |
Size:
|
7,494 bases |
Orientation:
|
plus strand |
|
Proteins
for ZFYVE19 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZFY19_HUMAN, Q96K21 (See
protein sequence)Recommended Name: Zinc finger FYVE domain-containing protein 19 Size: 471 amino acids; 51546 Da
Sequence caution: Sequence=AAH21092.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAO73862.1; Type=Frameshift; Positions=459; Sequence=BAB55338.1; Type=Erroneous initiation; Note=TranslationN-terminally extended;
Secondary accessions: B3KVB2 C9JNF4 H3BUF9 Q86WC2 Q8WU96Alternative splicing: 4 isoforms: Q96K21-1 Q96K21-2 Q96K21-3 Q96K21-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZFYVE19: NX_Q96K21
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96K21
ZFYVE19 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001070736.1 NP_001245349.1 NP_001245350.1 NP_116239.3
ENSEMBL proteins: ENSP00000456223 ENSP00000457617 ENSP00000347498 ENSP00000337824 ENSP00000299173 ENSP00000455157 ENSP00000452768 ENSP00000456304 ENSP00000453655 ENSP00000458096 ENSP00000454704 ENSP00000456679 ENSP00000456485 ENSP00000457839 ENSP00000456265
Human Recombinant Protein Products:
ZFYVE19 Antibody Products:
Assay Products for ZFYVE19: |
Protein
Domains /
Families
for ZFYVE19 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZFYVE19 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96K21ProtoNet protein and cluster: Q96K21 2 Blocks protein families: IPB000306 Zn-finger IPB001841 Zn-finger
UniProtKB/Swiss-Prot: ZFY19_HUMAN, Q96K21Similarity: Contains 1 FYVE-type zinc finger |
Function
for ZFYVE19 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFYVE19 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFYVE19 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZFYVE19 (NM_001077268) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZFYVE19 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFYVE19 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFYVE19 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
ZFYVE19 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZFYVE19:
|
Pathways & Interactions
for ZFYVE19 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFYVE19
1 Interacting protein for ZFYVE19 (Q96K213) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZFYVE19 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZFYVE19
Search CenterWatch for drugs/clinical trials and news about ZFYVE19 / ZFY19
|
Transcripts
for ZFYVE19 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZFYVE19 gene (4 alternative transcripts): NM_001077268.1 NM_001258420.1 NM_001258421.1 NM_032850.4 Unigene Cluster for ZFYVE19: Zinc finger, FYVE domain containing 19 Hs.121676 [show with all ESTs]Unigene Representative Sequence: NM_00107726818/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000570108 ENST00000564258 ENST00000355341(uc001zmt.1 uc001zmu.1 uc001zmv.1)
ENST00000336455 ENST00000299173 ENST00000568062 ENST00000563530 ENST00000560838
ENST00000566407 ENST00000559096 ENST00000567756 ENST00000561617 ENST00000569057
ENST00000561768 ENST00000560078 ENST00000566767 ENST00000565485 ENST00000570162
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFYVE19 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFYVE19 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZFYVE19 (NM_001077268) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZFYVE19 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFYVE19 |
Additional cDNA sequence: AF445414.1 AK027746.1 AK122779.1 AK225553.1 BC015738.1 BC021092.1 14 DOTS entries: DT.100703726 DT.95270602 DT.424941 DT.121061248 DT.121061200 DT.447001 DT.97855321 DT.121061265 DT.121061270 DT.100792339 DT.100642595 DT.95242113 DT.95242222 DT.95257371 24/184 AceView cDNA sequences (see all 184): BM045688 BG109829 BE302320 BG180231 BM693507 BQ881364 BM547466 BM561804 AA773608 CA489708 CR613477 BM977136 CR614847 AA761558 BQ009568 BM998461 BQ428312 BM925120 BM824270 BQ937181 BM676967 BQ438184 BM704933 CR621675
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE19 (see all 13) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ |
|---|
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| SP1: | | | - | | - | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | · | 15c |
|---|
|
| SP1: | - | | | | | | | | | | | | |
| SP2: | - | | | | | | | | | | | | |
| SP3: | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZFYVE19
|
Expression
for ZFYVE19 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZFYVE19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGGGAGAG
About this image
See ZFYVE19 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZFYVE19
SOURCE GeneReport for Unigene cluster: Hs.121676
UniProtKB/Swiss-Prot: ZFY19_HUMAN, Q96K21Tissue specificity: Detected in brain, heart, skeletal muscle, kidney and liver
SABiosciences Custom PCR Arrays for ZFYVE19
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFYVE19
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFYVE19 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFYVE19 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFYVE19 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFYVE19 |
Orthologs
for ZFYVE19 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZFYVE19 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for ZFYVE19 (if available)
TreeFam Gene Tree for ZFYVE19 (if available) |
Paralogs
for ZFYVE19 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZFYVE19 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZFYVE19 (41099274 - 41106767 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZFYVE19: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFYVE19 |
|
Disorders
/ Diseases
for ZFYVE19 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZFYVE19 for disorders About MalaCards
ZFYVE19 for disorders About GeneDecksing
UniProtKB/Swiss-Prot: ZFY19_HUMAN, Q96K21
Note=A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML).Translocation t(11;15)(q23;q14) with MLL/HRX
Export disorders for ZFYVE19 gene to outside databases
|
Publications
for ZFYVE19 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZFYVE19 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with ZFYVE19) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15. (PubMed id 12618766)1, 2 Chinwalla V....Rowley J.D. (2003)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. (PubMed id 19367720)2 Carrascal M.... Abian J. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for ZFYVE19 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZFYVE19 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZFYVE19 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZFYVE19 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZFYVE19 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZFYVE19 gene:
Search GeneIP for patents involving ZFYVE19
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZFYVE19 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZFYVE19 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFYVE19 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFYVE19 | | | OriGene Protein Over-expression Lysate for ZFYVE19 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZFYVE19 | | OriGene 3'-UTR Clone for ZFYVE19 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFYVE19 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFYVE19 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ZFYVE19 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFYVE19 |
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