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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFYVE19 Gene

protein-coding   GIFtS: 46
GCID: GC15P041099

Zinc Finger, FYVE Domain Containing 19

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, FYVE Domain Containing 191 2
MPFYVE2 3
MLL Partner Containing FYVE Domain2 3
Zinc Finger FYVE Domain-Containing Protein 192

External Ids:    HGNC: 207581   Entrez Gene: 849362   Ensembl: ENSG000001661407   UniProtKB: Q96K213   

Export aliases for ZFYVE19 gene to outside databases

Previous GC identifers: GC15P033995 GC15P038678 GC15P038815 GC15P038886 GC15P017947


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZFYVE19 Gene: 
ZFYVE19 (zinc finger, FYVE domain containing 19) is a protein-coding gene. Diseases associated with ZFYVE19 include leukemia. GO annotations related to this gene include zinc ion binding.

Gene Wiki entry for ZFYVE19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFYVE19 gene promoter:
         Bach1   AhR   Max1   Nkx2-5   PPAR-gamma1   IRF-7A   PPAR-gamma2   ATF6   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZFYVE19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFYVE19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q14

ZFYVE19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFYVE19 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P041099:  view genomic region     (about GC identifiers)

Start:
41,099,274 bp from pter      End:
41,106,767 bp from pter
Size:
7,494 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZFY19_HUMAN, Q96K21 (See protein sequence)
Recommended Name: Zinc finger FYVE domain-containing protein 19  
Size: 471 amino acids; 51546 Da
Sequence caution: Sequence=AAH21092.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAO73862.1; Type=Frameshift; Positions=459; Sequence=BAB55338.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: B3KVB2 C9JNF4 H3BUF9 Q86WC2 Q8WU96
Alternative splicing: 4 isoforms:  Q96K21-1   Q96K21-2   Q96K21-3   Q96K21-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFYVE19: NX_Q96K21

Explore proteomics data for ZFYVE19 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96K21

  • ZFYVE19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFYVE19 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001070736.1  NP_001245349.1  NP_001245350.1  NP_116239.3  

    ENSEMBL proteins: 
     ENSP00000456223   ENSP00000457617   ENSP00000347498   ENSP00000337824   ENSP00000299173  
     ENSP00000455157   ENSP00000456304   ENSP00000458096   ENSP00000454704   ENSP00000456679  
     ENSP00000456485   ENSP00000457839  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZFYVE: Zinc fingers, FYVE domain containing

    5 InterPro protein domains:
     IPR001841 Znf_RING
     IPR000306 Znf_FYVE
     IPR017455 Znf_FYVE-rel
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q96K21

    ProtoNet protein and cluster: Q96K21

    2 Blocks protein domains:
    IPB000306 Zn-finger
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: ZFY19_HUMAN, Q96K21
    Similarity: Contains 1 FYVE-type zinc finger


    ZFYVE19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    ZFYVE19 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZFYVE19:
     Increased cell death HMECs cel 

    Animal Models:
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    hsa-miR-622
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFYVE19

    1 Interacting protein for ZFYVE19 (Q96K213) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3BP5LQ7L8J43I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFYVE19 (ZFY19)

    Search CenterWatch for drugs/clinical trials and news about ZFYVE19 / ZFY19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFYVE19 gene (4 alternative transcripts): 
    NM_001077268.1  NM_001258420.1  NM_001258421.1  NM_032850.4  

    Unigene Cluster for ZFYVE19:

    Zinc finger, FYVE domain containing 19
    Hs.121676  [show with all ESTs]
    Unigene Representative Sequence: NM_001077268
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570108 ENST00000564258 ENST00000355341(uc001zmt.1 uc001zmu.1 uc001zmv.1)
    ENST00000336455 ENST00000299173 ENST00000568062 ENST00000563530 ENST00000566407
    ENST00000567756 ENST00000561617 ENST00000569057 ENST00000561768 ENST00000560078
    ENST00000566767 ENST00000570162 ENST00000563497
    miRNA
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    hsa-miR-622
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF445414.1 AK027746.1 AK122779.1 AK225553.1 BC015738.1 BC021092.1 

    14 DOTS entries:

    DT.100703726  DT.95270602  DT.424941  DT.121061248  DT.121061200  DT.447001  DT.97855321  DT.121061265 
    DT.121061270  DT.100792339  DT.100642595  DT.95242113  DT.95242222  DT.95257371 

    24/184 AceView cDNA sequences (see all 184):

    BG109829 AF445414 BU628326 CR614847 BM925120 BM704933 AI206219 BQ438184 
    CR625018 BE302320 NM_032850 AW015263 BM676967 BQ009568 CR613477 BM998461 
    CR603480 CR621675 CB241353 AK122779 AA761558 BM547466 BU734353 AL555420 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE19 (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^
    SP1:        -     -     -     -     -     -     -           -     -                                                                                             
    SP2:                                            -     -     -     -                                                                                             
    SP3:                                            -     -     -     -                                                                       -     -     -         
    SP4:                                            -     -     -     -     -     -     -                                                                           
    SP5:                                      -     -     -     -     -                                                                                             

    ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c
    SP1:  -                                 
    SP2:  -                                 
    SP3:  -                                 
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for ZFYVE19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFYVE19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGGGAGAG
    ZFYVE19 Expression
    About this image


    See ZFYVE19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFYVE19

    SOURCE GeneReport for Unigene cluster: Hs.121676

    UniProtKB/Swiss-Prot: ZFY19_HUMAN, Q96K21
    Tissue specificity: Detected in brain, heart, skeletal muscle, kidney and liver

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZFYVE19 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfyve191 , 5 zinc finger, FYVE domain containing 191, 5 82.86(n)1
    81.91(a)1
      2 (59.97 cM)5
    720081  NM_028054.31  NP_082330.21 
     1192086175 
    chicken
    (Gallus gallus)
    Aves ZFYVE191 zinc finger, FYVE domain containing 19 63.75(n)
    63.75(a)
      423204  NM_001199652.1  NP_001186581.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZFYVE196
    zinc finger, FYVE domain containing 19
    57(a)
    1 ↔ 1
    GL343264.1(446821-461624)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX728472.12   -- 74.72(n)    BX728472.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.61842 Transcribed sequences 79.4(n)    BQ074816.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG156021 CG15602 42.6(n)
    33.44(a)
      32533  NM_132849.2  NP_573077.2 


    ENSEMBL Gene Tree for ZFYVE19 (if available)
    TreeFam Gene Tree for ZFYVE19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/192 SNPs in ZFYVE19 are shown (see all 192)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821787851,2
    --41101715(+) ATAGGA/GAAAGA 4 -- int10--------
    rs1861405321,2
    --41101721(+) AAAGAA/CCCTGC 4 -- int10--------
    rs1464009221,2
    --41101795(+) GCCCTC/TTTGGG 4 -- int10--------
    rs751752931,2
    C,F--41101816(+) AGCTCT/GTCAGC 4 -- int11Minor allele frequency- G:0.03EA 120
    rs1396747151,2
    --41101834(+) CCAGGA/TCAGGC 4 -- int10--------
    rs1429329711,2
    --41101870(+) TGGACC/TGTCTG 4 -- int10--------
    rs798351061,2
    F--41101877(+) TCTGGC/TTGGTC 4 -- int11Minor allele frequency- T:0.01WA 118
    rs1165566741,2
    C,F--41101907(+) GTGACA/GTGAGT 4 -- int11Minor allele frequency- G:0.03WA 118
    rs1395187381,2
    C,F--41102015(+) CTCTGC/ACTTCT 4 -- int11Minor allele frequency- A:0.01EU 1323
    rs2010058581,2
    --41102029(+) AGAGCC/TTCTAT 4 -- int10--------

    HapMap Linkage Disequilibrium report for ZFYVE19 (41099274 - 41106767 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZFYVE19:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv272589CNV Insertion20981092
    esv267815CNV Insertion20981092
    nsv904102CNV Loss21882294
    nsv904101CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFYVE19
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFYVE19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UniProtKB/Swiss-Prot: ZFY19_HUMAN, Q96K21
  • Note=A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML).
    Translocation t(11;15)(q23;q14) with KMT2A/MLL1

  • 2 diseases for ZFYVE19:    About MalaCards
    leukemia    


    ZFYVE19 for disorders           About GeneDecksing


    Export disorders for ZFYVE19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFYVE19 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with ZFYVE19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15. (PubMed id 12618766)1, 2 Chinwalla V....Rowley J.D. (2003)
    4. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. (PubMed id 19367720)2 Carrascal M.... Abian J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84936 HGNC: 20758 AceView: ZFYVE19 Ensembl:ENSG00000166140 euGenes: HUgn84936
    ECgene: ZFYVE19 H-InvDB: ZFYVE19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFYVE19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFYVE19 gene:
    Search GeneIP for patents involving ZFYVE19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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