Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZFYVE16 Gene

Aliases for ZFYVE16 Gene

  • Zinc Finger, FYVE Domain Containing 16 2 3
  • KIAA0305 4 6
  • ENDOFIN 4 6
  • Zinc Finger FYVE Domain-Containing Protein 16 3
  • Protein Phosphatase 1, Regulatory Subunit 69 3
  • Endosome-Associated FYVE-Domain Protein 3
  • Endosome-Associated FYVE Domain Protein 4
  • Protein Phosphatase 1 2
  • Regulatory Subunit 69 2
  • Endofin 2
  • PPP1R69 3

External Ids for ZFYVE16 Gene

Previous GeneCards Identifiers for ZFYVE16 Gene

  • GC05P079942
  • GC05P079742
  • GC05P079787
  • GC05P079739
  • GC05P074911
  • GC05P079704

Summaries for ZFYVE16 Gene

Entrez Gene Summary for ZFYVE16 Gene

  • This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for ZFYVE16 Gene

ZFYVE16 (Zinc Finger, FYVE Domain Containing 16) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Endocytosis. GO annotations related to this gene include protein transporter activity and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is ZFYVE28.

UniProtKB/Swiss-Prot for ZFYVE16 Gene

  • May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.

Gene Wiki entry for ZFYVE16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFYVE16 Gene

Genomics for ZFYVE16 Gene

Regulatory Elements for ZFYVE16 Gene

Genomic Location for ZFYVE16 Gene

80,407,570 bp from pter
80,479,869 bp from pter
72,300 bases
Plus strand

Genomic View for ZFYVE16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFYVE16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFYVE16 Gene

Proteins for ZFYVE16 Gene

  • Protein details for ZFYVE16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger FYVE domain-containing protein 16
    Protein Accession:
    Secondary Accessions:
    • O15023
    • Q5H9U2
    • Q7LAU7
    • Q86T69
    • Q8N5L3
    • Q8NEK3

    Protein attributes for ZFYVE16 Gene

    1539 amino acids
    Molecular mass:
    168903 Da
    Quaternary structure:
    • Interacts with the C-terminus of TOM1. Does not interact with TOM1L1 or TOM1L2.
    • Sequence=BAA20764.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZFYVE16 Gene

    Alternative splice isoforms for ZFYVE16 Gene


neXtProt entry for ZFYVE16 Gene

Proteomics data for ZFYVE16 Gene at MOPED

Post-translational modifications for ZFYVE16 Gene

  • Ubiquitination at Lys650
  • Modification sites at PhosphoSitePlus

Other Protein References for ZFYVE16 Gene

No data available for DME Specific Peptides for ZFYVE16 Gene

Domains for ZFYVE16 Gene

Gene Families for ZFYVE16 Gene

  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
  • ZFYVE :Zinc fingers, FYVE domain containing

Protein Domains for ZFYVE16 Gene

Suggested Antigen Peptide Sequences for ZFYVE16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q7Z3T8
  • The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P.
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with ZFYVE16: view

Function for ZFYVE16 Gene

Molecular function for ZFYVE16 Gene

UniProtKB/Swiss-Prot Function: May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.

Gene Ontology (GO) - Molecular Function for ZFYVE16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14613930
GO:0005545 1-phosphatidylinositol binding IDA 11546807
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 11433298
GO:0008565 protein transporter activity IMP 11546807
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFYVE16: view

Phenotypes for ZFYVE16 Gene

GenomeRNAi human phenotypes for ZFYVE16:
genes like me logo Genes that share phenotypes with ZFYVE16: view

miRNA for ZFYVE16 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFYVE16 Gene

Localization for ZFYVE16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFYVE16 Gene

Cytoplasm. Early endosome membrane; Peripheral membrane protein. Note=Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P).

Subcellular locations from

Jensen Localization Image for ZFYVE16 Gene COMPARTMENTS Subcellular localization image for ZFYVE16 gene
Compartment Confidence
endosome 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for ZFYVE16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005769 early endosome IDA 11546807
GO:0031901 early endosome membrane TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ZFYVE16: view

Pathways for ZFYVE16 Gene

genes like me logo Genes that share pathways with ZFYVE16: view

Pathways by source for ZFYVE16 Gene

2 BioSystems pathways for ZFYVE16 Gene
2 Reactome pathways for ZFYVE16 Gene
2 KEGG pathways for ZFYVE16 Gene

Gene Ontology (GO) - Biological Process for ZFYVE16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006622 protein targeting to lysosome IMP 11546807
GO:0007165 signal transduction NAS 11546807
GO:0016050 vesicle organization NAS 11546807
GO:0016197 endosomal transport IMP 11546807
GO:0030100 regulation of endocytosis TAS 11546807
genes like me logo Genes that share ontologies with ZFYVE16: view

Compounds for ZFYVE16 Gene

(1) Novoseek inferred chemical compound relationships for ZFYVE16 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylinositol 49.5 1
genes like me logo Genes that share compounds with ZFYVE16: view

Transcripts for ZFYVE16 Gene

Unigene Clusters for ZFYVE16 Gene

Zinc finger, FYVE domain containing 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE16 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7: - - -
SP8: - - - - - -

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c

Relevant External Links for ZFYVE16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFYVE16 Gene

mRNA expression in normal human tissues for ZFYVE16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFYVE16 Gene

SOURCE GeneReport for Unigene cluster for ZFYVE16 Gene Hs.482660

mRNA Expression by UniProt/SwissProt for ZFYVE16 Gene

Tissue specificity: Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes.
genes like me logo Genes that share expressions with ZFYVE16: view

No data available for mRNA differential expression in normal tissues for ZFYVE16 Gene

Orthologs for ZFYVE16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFYVE16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFYVE16 35
  • 99.26 (n)
  • 98.44 (a)
ZFYVE16 36
  • 98 (a)
(Bos Taurus)
Mammalia ZFYVE16 35
  • 89.4 (n)
  • 84.43 (a)
ZFYVE16 36
  • 84 (a)
(Canis familiaris)
Mammalia ZFYVE16 35
  • 89.82 (n)
  • 85.55 (a)
ZFYVE16 36
  • 85 (a)
(Mus musculus)
Mammalia Zfyve16 35
  • 81.5 (n)
  • 74.19 (a)
Zfyve16 16
Zfyve16 36
  • 74 (a)
(Monodelphis domestica)
Mammalia ZFYVE16 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia ZFYVE16 36
  • 60 (a)
(Rattus norvegicus)
Mammalia Zfyve16 35
  • 80.25 (n)
  • 73.12 (a)
(Gallus gallus)
Aves ZFYVE16 35
  • 61.34 (n)
  • 50.17 (a)
ZFYVE16 36
  • 48 (a)
(Anolis carolinensis)
Reptilia ZFYVE16 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zfyve16 35
  • 62.91 (n)
  • 58.75 (a)
(Danio rerio)
Actinopterygii zfyve16 35
  • 54.09 (n)
  • 49.24 (a)
zfyve16 36
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAB1 36
  • 7 (a)
Species with no ortholog for ZFYVE16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFYVE16 Gene

Gene Tree for ZFYVE16 (if available)
Gene Tree for ZFYVE16 (if available)

Paralogs for ZFYVE16 Gene

Paralogs for ZFYVE16 Gene

Selected SIMAP similar genes for ZFYVE16 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZFYVE16: view

Variants for ZFYVE16 Gene

Sequence variations from dbSNP and Humsavar for ZFYVE16 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs10433 -- 80,479,087(-) TGAAT(A/G)TAGAG utr-variant-3-prime
rs166062 -- 80,477,209(-) AAAAA(A/C)AAAAA intron-variant
rs168938 -- 80,424,033(+) ctcca(C/T)ctccc intron-variant
rs168939 -- 80,440,039(+) TGAGT(A/G)TTAAC intron-variant, reference, missense
rs173599 -- 80,464,703(-) tttac(A/T)agagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFYVE16 Gene

Variant ID Type Subtype PubMed ID
nsv518480 CNV Gain 19592680

Relevant External Links for ZFYVE16 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFYVE16 Gene

Disorders for ZFYVE16 Gene

Relevant External Links for ZFYVE16

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ZFYVE16: view

No data available for UniProtKB/Swiss-Prot for ZFYVE16 Gene

Publications for ZFYVE16 Gene

  1. Endofin, an endosomal FYVE domain protein. (PMID: 11546807) Seet L.-F. … Hong W. (J. Biol. Chem. 2001) 2 3 4 23
  2. Endofin recruits TOM1 to endosomes. (PMID: 14613930) Seet L.-F. … Hong W. (J. Biol. Chem. 2004) 3 4 23
  3. EGF-induced tyrosine phosphorylation of Endofin is dependent on PI3K activity and proper localization to endosomes. (PMID: 19887107) Toy W. … Lim Y.P. (Cell. Signal. 2010) 3 23
  4. Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling. (PMID: 17272273) Chen Y.G. … Lu Z. (J. Biol. Chem. 2007) 3 23
  5. Endofin acts as a Smad anchor for receptor activation in BMP signaling. (PMID: 17356069) Shi W. … Cao X. (J. Cell. Sci. 2007) 3 23

Products for ZFYVE16 Gene

Sources for ZFYVE16 Gene

Back to Top