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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFYVE16 Gene

protein-coding   GIFtS: 57
GCID: GC05P079739

Zinc Finger, FYVE Domain Containing 16

  Search for ZFYVE16
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, FYVE Domain Containing 161 2     Protein Phosphatase 1, Regulatory Subunit 692
endofin1     Zinc Finger FYVE Domain-Containing Protein 162
Protein Phosphatase 11     Endofin3
Regulatory Subunit 691     KIAA03053
PPP1R692     Endosome-Associated FYVE Domain Protein3
Endosome-Associated FYVE-Domain Protein2     

External Ids:    HGNC: 207561   Entrez Gene: 97652   Ensembl: ENSG000000393197   OMIM: 6088805   UniProtKB: Q7Z3T83   

Export aliases for ZFYVE16 gene to outside databases

Previous GC identifers: GC05P079942 GC05P079742 GC05P079787 GC05P074911


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZFYVE16 Gene:
This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded
protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein
in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback
regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript
variants. (provided by RefSeq, Sep 2013)

GeneCards Summary for ZFYVE16 Gene: 
ZFYVE16 (zinc finger, FYVE domain containing 16) is a protein-coding gene. Among its related super-pathways are BMP signalling and regulation and Signaling by GPCR. GO annotations related to this gene include protein transporter activity and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is ZFYVE9.

UniProtKB/Swiss-Prot: ZFY16_HUMAN, Q7Z3T8
Function: May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces
endosome aggregation. Required to target TOM1 to endosomes

Gene Wiki entry for ZFYVE16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFYVE16 gene promoter:
         C/EBPbeta   POU2F1   AML1a   AP-1   POU2F1a   ATF-2   Msx-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFYVE16 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFYVE16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFYVE16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q14.1

ZFYVE16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFYVE16 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P079739:  view genomic region     (about GC identifiers)

Start:
79,703,832 bp from pter      End:
79,775,498 bp from pter
Size:
71,667 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZFY16_HUMAN, Q7Z3T8 (See protein sequence)
Recommended Name: Zinc finger FYVE domain-containing protein 16  
Size: 1539 amino acids; 168903 Da
Subunit: Interacts with the C-terminus of TOM1. Does not interact with TOM1L1 or TOM1L2
Subcellular location: Cytoplasm. Early endosome membrane; Peripheral membrane protein. Note=Localized to early
endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P)
Sequence caution: Sequence=BAA20764.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for ZFYVE16:
3T7L (3D)    
Secondary accessions: O15023 Q5H9U2 Q7LAU7 Q86T69 Q8N5L3 Q8NEK3
Alternative splicing: 2 isoforms:  Q7Z3T8-1   Q7Z3T8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFYVE16: NX_Q7Z3T8

Explore proteomics data for ZFYVE16 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z3T8

  • ZFYVE16 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFYVE16 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001098721.1  NP_001271165.1  NP_001271166.1  NP_055548.3  

    ENSEMBL proteins: 
     ENSP00000337159   ENSP00000423663   ENSP00000426848   ENSP00000422356   ENSP00000426536  
     ENSP00000421785   ENSP00000426500  
    Reactome Protein details: Q7Z3T8
    Human Recombinant Protein Products for ZFYVE16: 
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    Novus Biologicals ZFYVE16 Proteins
    Novus Biologicals ZFYVE16 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZFYVE16 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005769early endosome IDA11546807
    GO:0031901early endosome membrane TAS--
    GO:0043231intracellular membrane-bounded organelle IDA--

    ZFYVE16 for ontologies           About GeneDecksing



    ZFYVE16 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZFYVE: Zinc fingers, FYVE domain containing
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    5/6 InterPro protein domains (see all 6):
     IPR000306 Znf_FYVE
     IPR017455 Znf_FYVE-rel
     IPR017165 Znf_FYVE_SARA/endofin
     IPR013083 Znf_RING/FYVE/PHD
     IPR022557 DUF3480

    Graphical View of Domain Structure for InterPro Entry Q7Z3T8

    ProtoNet protein and cluster: Q7Z3T8

    1 Blocks protein domain: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: ZFY16_HUMAN, Q7Z3T8
    Domain: The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and
    mediates the association with PI3P
    Similarity: Contains 1 FYVE-type zinc finger


    ZFYVE16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFY16_HUMAN, Q7Z3T8
    Function: May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces
    endosome aggregation. Required to target TOM1 to endosomes

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14613930
    GO:00055451-phosphatidylinositol binding IDA11546807
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IDA11433298
    GO:0008565protein transporter activity IMP11546807
    GO:0046872metal ion binding IEA--
         
    ZFYVE16 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZFYVE16:
     Synthetic lethal with Ras 

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZFYVE16 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by BMP
    Signaling by BMP0.35
    BMP receptor signaling0.31
    2Signaling by GPCR
    Signal Transduction0.55
    3TGF-beta signaling pathway
    TGF-beta signaling pathway
    4TGF-beta receptor signaling
    TGF-beta receptor signaling
    5Endocytosis
    Endocytosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for ZFYVE16
        TGF-beta receptor signaling
    BMP receptor signaling

    2        Reactome Pathways for ZFYVE16
        Signal Transduction
    Signaling by BMP


    2         Kegg Pathways  (Kegg details for ZFYVE16):
        Endocytosis
    TGF-beta signaling pathway


    ZFYVE16 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFYVE16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/28 Interacting proteins for ZFYVE16 (Q7Z3T81, 2, 3 ENSP000003371594) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAP621362, 3MINT-62205 I2D: score=3 
    RNF11Q9Y3C52, 3MINT-60843 I2D: score=3 
    TOM1O607841, 3, ENSP000004136974EBI-298055,EBI-74634 I2D: score=5 STRING: ENSP00000413697
    SMAD4Q134853, ENSP000003415514I2D: score=1 STRING: ENSP00000341551
    TGFBR1P368973, ENSP000003641334I2D: score=1 STRING: ENSP00000364133
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006622protein targeting to lysosome IMP11546807
    GO:0007165signal transduction NAS11546807
    GO:0016050vesicle organization NAS11546807
    GO:0016197endosomal transport IMP11546807
    GO:0030100regulation of endocytosis TAS11546807

    ZFYVE16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZFYVE16 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFYVE16 (ZFY16)

    1 Novoseek inferred chemical compound relationship for ZFYVE16 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 49.5 3 19887107 (1)

    Search CenterWatch for drugs/clinical trials and news about ZFYVE16 / ZFY16

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFYVE16 gene (4 alternative transcripts): 
    NM_001105251.2  NM_001284236.1  NM_001284237.1  NM_014733.4  

    Unigene Cluster for ZFYVE16:

    Zinc finger, FYVE domain containing 16
    Hs.482660  [show with all ESTs]
    Unigene Representative Sequence: NM_001105251
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338008(uc003kgr.4 uc003kgq.4 uc003kgs.4 uc003kgt.4)
    ENST00000510158 ENST00000505560 ENST00000512558(uc003kgp.3) ENST00000509562
    ENST00000510995(uc010jak.2) ENST00000512442 ENST00000511050 ENST00000511829
    ENST00000509558 ENST00000507548 ENST00000512907(uc003kgu.4) ENST00000513789

    miRNA
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    Additional mRNA sequence: 

    AB002303.1 AF434817.1 AK090896.1 AK127003.1 AL833087.2 BC030808.1 BX537424.1 CR933621.1 

    12 DOTS entries:

    DT.75161116  DT.101983544  DT.75135092  DT.416510  DT.101983543  DT.75100255  DT.92429515  DT.100025221 
    DT.120873316  DT.425603  DT.95259779  DT.120873281 

    24/160 AceView cDNA sequences (see all 160):

    AA349902 AA235268 N21588 AV717110 AA349901 CA388945 AA443383 AF434817 
    CA393193 AI243668 BU735599 N23475 AI362488 BX106860 AA815426 BM925782 
    BM976393 BM052610 AI493297 AI282629 BM052837 AA349613 AA864794 AL705583 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE16 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
    SP1:                                -           -                                   -     -                                               -                     
    SP2:                          -     -           -                                   -     -                                               -                     
    SP3:                                                                                                        -                             -                     
    SP4:                          -     -           -                                   -     -                                                                     
    SP5:                          -     -                                                                                                                           

    ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for ZFYVE16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFYVE16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZFYVE16 Expression
    About this image


    See ZFYVE16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFYVE16

    SOURCE GeneReport for Unigene cluster: Hs.482660

    UniProtKB/Swiss-Prot: ZFY16_HUMAN, Q7Z3T8
    Tissue specificity: Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate
    level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood
    lymphocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZFYVE16 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfyve161 , 5 zinc finger, FYVE domain containing 161, 5 81.46(n)1
    74.19(a)1
      13 (47.72 cM)5
    2184411  NM_173392.41  NP_775568.11 
     924871085 
    chicken
    (Gallus gallus)
    Aves ZFYVE161 zinc finger, FYVE domain containing 16 60.96(n)
    49.97(a)
      427315  XM_424894.3  XP_424894.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZFYVE166
    zinc finger, FYVE domain containing 16
    44(a)
    1 ↔ 1
    2(17093009-17122348)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7946891 zinc finger FYVE domain-containing protein 16-like 51.01(n)
    43.99(a)
      794689  XM_001920883.2  XP_001920918.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sara6
    Smad anchor for receptor activation
    25(a)
    1 → many
    2R(17369424-17374618)
    worm
    (Caenorhabditis elegans)
    Secernentea aka-16
    Protein AKA-1, isoform a
    18(a)
    1 → many
    II(7472729-7478959)


    ENSEMBL Gene Tree for ZFYVE16 (if available)
    TreeFam Gene Tree for ZFYVE16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFYVE16 gene
    ZFYVE92  PIKFYVE2  ZFYVE212  ZFYVE282  
    1 SIMAP similar gene for ZFYVE16 using alignment to 5 protein entries:     ZFY16_HUMAN (see all proteins):
    ZFYVE9

    ZFYVE16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1670 SNPs in ZFYVE16 are shown (see all 1670)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0194904
    ----see VAR_0194902 I T mis40--------
    VAR_0194914
    ----see VAR_0194912 S G mis40--------
    VAR_0693684
    ----see VAR_0693682 A V mis40--------
    rs131880881,2
    C,F,H--79701839(+) ATTTCA/GTATTT 2 -- us2k125Minor allele frequency- G:0.12NS EA NA WA 3002
    rs2590491,2
    C,H--79701886(+) CTATTT/GAAGGT 2 -- us2k114Minor allele frequency- G:0.00NS EA WA NA CSA 668
    rs1927123721,2
    --79701933(+) TTTACC/TGTATA 2 -- us2k10--------
    rs1472580511,2
    --79701961(+) TATGCA/GTTTGT 2 -- us2k10--------
    rs1154402061,2
    F--79702006(+) CATGGG/TCAGTG 2 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1843348261,2
    C--79702052(+) ACATAA/GTAGGA 2 -- us2k10--------
    rs1892256521,2
    --79702125(+) ATCTAA/GCACAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZFYVE16 (79703832 - 79775498 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZFYVE16:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv518480CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ZFYVE16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZFYVE16 for disorders           About MalaCards
    OMIM gene information: 608880    OMIM disorders: --


    ZFYVE16 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZFYVE16

    Export disorders for ZFYVE16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFYVE16 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with ZFYVE16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Endofin, an endosomal FYVE domain protein. (PubMed id 11546807)1, 2, 3, 9 Seet L.-F. and Hong W. (2001)
    2. Endofin recruits TOM1 to endosomes. (PubMed id 14613930)1, 2, 9 Seet L.-F.... Hong W. (2004)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (1997)
    7. EGF-induced tyrosine phosphorylation of Endofin is de pendent on PI3K activity and proper localization to endosomes. (PubMed id 19887107)1, 9 Toy W....Lim Y.P. (2010)
    8. Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling. (PubMed id 17272273)1, 9 Chen Y.G....Lu Z. (2007)
    9. Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells. (PubMed id 17570516)1, 9 Chen Y....Lim Y.P. (2007)
    10. Endofin acts as a Smad anchor for receptor activation in BMP signaling. (PubMed id 17356069)1, 9 Shi W....Cao X. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9765 HGNC: 20756 AceView: ZFYVE16 Ensembl:ENSG00000039319 euGenes: HUgn9765
    ECgene: ZFYVE16 Kegg: 9765 H-InvDB: ZFYVE16

    (According to HUGE)
    About This Section
    HUGE: KIAA0305

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFYVE16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFYVE16 gene:
    Search GeneIP for patents involving ZFYVE16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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