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ZFYVE1 Gene

protein-coding   GIFtS: 50
GCID: GC14M073436

Zinc Finger, FYVE Domain Containing 1

(Previous names: zinc finger protein, subfamily 2A (FYVE domain containing),...)
(Previous symbol: ZNFN2A1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, FYVE Domain Containing 11 2     Phosphoinositide-Binding Protein SR32
ZNFN2A11 2 3 5     Tandem FYVE Fingers-1 Protein2
DFCP12 3 5     Zinc Finger FYVE Domain-Containing Protein 12
Double FYVE-Containing Protein 12 3     Zinc Finger Protein, Subfamily 2A, Member 12
SR32 3     KIAA15893
TAFF12 3     Tandem FYVE Fingers-13
Zinc Finger Protein, Subfamily 2A (FYVE Domain Containing), 11     

External Ids:    HGNC: 131801   Entrez Gene: 533492   Ensembl: ENSG000001658617   OMIM: 6054715   UniProtKB: Q9HBF43   

Export aliases for ZFYVE1 gene to outside databases

Previous GC identifers: GC14M067231 GC14M071426 GC14M072505 GC14M053602


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZFYVE1 Gene:
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to
phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in
tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for ZFYVE1 Gene:
ZFYVE1 (zinc finger, FYVE domain containing 1) is a protein-coding gene. Diseases associated with ZFYVE1 include blepharospasm, and retinoschisis. GO annotations related to this gene include phosphatidylinositol-3,4-bisphosphate binding and 1-phosphatidylinositol binding.

Gene Wiki entry for ZFYVE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFYVE1 gene promoter:
         SRF   Pbx1a   SRF (504 AA)   p300   POU3F2 (N-Oct-5a)   RelA   POU3F2   NF-kappaB   SRY   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFYVE1 promoter sequence
   Search Chromatin IP Primers for ZFYVE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFYVE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.2   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.2

ZFYVE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFYVE1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M073436:  view genomic region     (about GC identifiers)

Start:
73,436,159 bp from pter      End:
73,493,920 bp from pter
Size:
57,762 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZFYV1_HUMAN, Q9HBF4 (See protein sequence)
Recommended Name: Zinc finger FYVE domain-containing protein 1  
Size: 777 amino acids; 87176 Da
Subunit: Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger
Sequence caution: Sequence=AAL55826.1; Type=Frameshift; Positions=480; Sequence=BAB13415.1; Type=Erroneous
initiation; Sequence=BAB55085.1; Type=Erroneous termination; Positions=760; Note=Translated as Trp;
Secondary accessions: Q8WYX7 Q96K57 Q9BXP9 Q9HCI3
Alternative splicing: 2 isoforms:  Q9HBF4-1   Q9HBF4-2   

Explore the universe of human proteins at neXtProt for ZFYVE1: NX_Q9HBF4

Explore proteomics data for ZFYVE1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZFYVE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001268663.1  NP_001268664.1  NP_067083.1  NP_848535.1  

    ENSEMBL proteins: 
     ENSP00000452442   ENSP00000326921   ENSP00000450742   ENSP00000377757   ENSP00000452232  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFYVE: Zinc fingers, FYVE domain containing

    5 InterPro protein domains:
     IPR000306 Znf_FYVE
     IPR013083 Znf_RING/FYVE/PHD
     IPR027417 P-loop_NTPase
     IPR017455 Znf_FYVE-rel
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q9HBF4

    ProtoNet protein and cluster: Q9HBF4

    1 Blocks protein domain: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: ZFYV1_HUMAN, Q9HBF4
    Similarity: Contains 2 FYVE-type zinc fingers


    ZFYVE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19389623
    GO:00055451-phosphatidylinositol binding IDA11256955
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IDA11804589
    GO:0008270zinc ion binding NAS11739631
    GO:0043325phosphatidylinositol-3,4-bisphosphate binding IDA11804589
         
    ZFYVE1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZFYVE1:
     Decreased melanin production 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZFYVE1
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    miRNA
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    miRTarBase miRNAs that target ZFYVE1:
    hsa-mir-335-5p (MIRT018968), hsa-mir-125b-5p (MIRT046077)

    Block miRNA regulation of human, mouse, rat ZFYVE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFYVE1 (see all 43):
    hsa-miR-631 hsa-miR-146a hsa-miR-650 hsa-miR-3167 hsa-miR-3150b-3p hsa-miR-3612 hsa-miR-4324 hsa-miR-588
    SwitchGear 3'UTR luciferase reporter plasmidZFYVE1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZFYV1_HUMAN, Q9HBF4: Golgi apparatus, Golgi stack. Endoplasmic reticulum. Note=Resides predominantly in the
    cisternal stacks of the Golgi. Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    cytosol3
    nucleus2
    vacuole2
    endosome1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA11739631
    GO:0005795Golgi stack IDA11256955
    GO:0048471perinuclear region of cytoplasm IDA11739631

    ZFYVE1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFYVE1
    Interactions:

        Search GeneGlobe Interaction Network for ZFYVE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZFYVE1 (Q9HBF41, 2, 3 ENSP000003269214) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2L1Q078172, 3, ENSP000003025644MINT-8249432 I2D: score=2 STRING: ENSP00000302564
    PPP1CAP621361, ENSP000003260314EBI-4401611,EBI-357253 STRING: ENSP00000326031
    TRIM13ENSP000002987724STRING: ENSP00000298772
    COPAENSP000003570484STRING: ENSP00000357048
    COPEENSP000002628124STRING: ENSP00000262812
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010923negative regulation of phosphatase activity IDA19389623

    ZFYVE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFYVE1 (ZFYV1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZFYVE1 gene (4 alternative transcripts): 
    NM_001281734.1  NM_001281735.1  NM_021260.3  NM_178441.2  

    Unigene Cluster for ZFYVE1:

    Zinc finger, FYVE domain containing 1
    Hs.335106  [show with all ESTs]
    Unigene Representative Sequence: NM_021260
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553891 ENST00000318876 ENST00000556143(uc001xnl.3 uc001xnm.3 uc010arj.3)
    ENST00000394207 ENST00000555072 ENST00000556040 ENST00000556761 ENST00000554145
    ENST00000554250
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZFYVE1 (see all 43):
    hsa-miR-631 hsa-miR-146a hsa-miR-650 hsa-miR-3167 hsa-miR-3150b-3p hsa-miR-3612 hsa-miR-4324 hsa-miR-588
    SwitchGear 3'UTR luciferase reporter plasmidZFYVE1 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ZFYVE1
      QuantiFast Probe-based Assays in human, mouse, rat ZFYVE1

    Additional mRNA sequence: 

    AB046809.1 AF251025.2 AF311602.1 AF318319.1 AJ310569.1 AK027399.1 AK098542.1 BC014902.1 
    BC053520.1 

    6 DOTS entries:

    DT.415049  DT.92420635  DT.100785036  DT.100025573  DT.65287725  DT.120769073 

    Selected AceView cDNA sequences (see all 135):

    NM_021260 BU182869 H43848 AJ310569 BQ436330 CB159624 AL708663 NM_178441 
    BQ642624 BQ894836 CA415657 BQ066626 BM666311 BC053520 AK098542 AF311602 
    AK027399 CA454782 BU740588 AI611277 AB046809 AF251025 BM801852 AA888829 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b
    SP1:                                -     -           -                                   -           -                           
    SP2:                                -     -           -                 -                 -           -                           
    SP3:                                                  -                                   -           -                           
    SP4:                                                  -                                   -           -                           
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for ZFYVE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFYVE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZFYVE1 Expression
    About this image

    ZFYVE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFYVE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.335106

    UniProtKB/Swiss-Prot: ZFYV1_HUMAN, Q9HBF4
    Tissue specificity: Isoform 1 is expressed in all tissues examined, including, brain, placenta, lung, liver,
    skeletal muscle, pancreas and kidney. Isoform 1 and isoform 2 are highly expressed in heart. Isoform 2 is also
    detected in the testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZFYVE1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfyve11 , 5 zinc finger, FYVE domain containing 11, 5 90.18(n)1
    96.65(a)1
      12 (38.76 cM)5
    2176951  NM_183154.31  NP_898977.21 
     835469415 
    chicken
    (Gallus gallus)
    Aves ZFYVE11 zinc finger, FYVE domain containing 1 80.84(n)
    89.82(a)
      423252  NM_001199686.1  NP_001186615.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZFYVE16
    zinc finger, FYVE domain containing 1
    86(a)
    1 ↔ 1
    1(38858453-38886864)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.163262 Xenopus laevis transcribed sequence with weak similarity more 78.95(n)    CD328508.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.188062 Transcribed sequence with weak similarity to protein more 73.38(n)    BQ618467.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0020361 AgaP_AGAP002036 55.03(n)
    50(a)
      1281077  XM_321014.5  XP_321014.5 


    ENSEMBL Gene Tree for ZFYVE1 (if available)
    TreeFam Gene Tree for ZFYVE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZFYVE1 gene

    ZFYVE1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZFYVE1
    PGOHUM00000246876


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFYVE1 (see all 1432)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs341317401,2
    C--54482505(+) CCCTC-/AAAAAA 1 -- int10--------
    rs20020341,2
    C,F,A--73435660(-) ccaggC/Tgcggt 2 -- ds5001 int14Minor allele frequency- T:0.38NA WA 8
    rs1501408591,2
    --73435718(+) CTACAG/TTGCAA 2 -- ds5001 int10--------
    rs1386148541,2
    --73435773(+) CAAGCA/GATTCT 2 -- ds5001 int10--------
    rs1162940841,2
    C,F--73435919(+) CCCTCC/TGGCCT 2 -- ds5001 int11Minor allele frequency- T:0.03WA 118
    rs1134333711,2
    C,F--73435920(+) CCTCCG/AGCCTT 2 -- ds5001 int12Minor allele frequency- A:0.08CSA WA 120
    rs781123111,2
    C,F--73435924(+) CGGCCC/TTGGCC 2 -- ds5001 int12Minor allele frequency- T:0.50WA CSA 4
    rs1179468151,2
    C,F--73435975(+) AGCCGG/CCTATG 2 -- ds5001 int11Minor allele frequency- C:0.03NA 120
    rs1474916811,2
    --73436043(+) ATTACC/TGCCCT 2 -- ds5001 int10--------
    rs1878520911,2
    --73436160(+) GAGATA/GCAGGA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ZFYVE1 (73436159 - 73493920 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZFYVE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1348CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFYVE1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605471    OMIM disorders: --

    3 diseases for ZFYVE1:    About MalaCards
    blepharospasm    retinoschisis    malaria


    ZFYVE1 for disorders           About GeneDecksing


    Export disorders for ZFYVE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFYVE1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ZFYVE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library. (PubMed id 11024279)1, 2, 3, 9 Derubeis A.R.... Fisher L.W. (Gene 2000)
    2. Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi. (PubMed id 11256955)1, 2, 3 Cheung P.C.F.... Lucocq J.M. (Biochem. J. 2001)
    3. TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells. (PubMed id 22178386)1, 2 Tomar D.... Singh R. (Biochim. Biophys. Acta 2012)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    8. FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. (PubMed id 11739631)1, 2 Ridley S.H.... Hawkins P.T. (J. Cell Sci. 2001)
    9. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    10. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 53349 HGNC: 13180 AceView: ZFYVE1 Ensembl:ENSG00000165861 euGenes: HUgn53349
    ECgene: ZFYVE1 H-InvDB: ZFYVE1

    (According to HUGE)
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    HUGE: KIAA1589

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZFYVE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFYVE1 gene:
    Search GeneIP for patents involving ZFYVE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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