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Aliases for ZFYVE1 Gene

Aliases for ZFYVE1 Gene

  • Zinc Finger FYVE-Type Containing 1 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 172 2 3
  • Zinc Finger, FYVE Domain Containing 1 2 3
  • Double FYVE-Containing Protein 1 3 4
  • ZNFN2A1 3 4
  • DFCP1 3 4
  • TAFF1 3 4
  • SR3 3 4
  • Zinc Finger Protein, Subfamily 2A (FYVE Domain Containing), 1 2
  • Zinc Finger FYVE Domain-Containing Protein 1 3
  • Zinc Finger Protein, Subfamily 2A, Member 1 3
  • Phosphoinositide-Binding Protein SR3 3
  • Tandem FYVE Fingers-1 Protein 3
  • Tandem FYVE Fingers-1 4
  • PPP1R172 3
  • KIAA1589 4

External Ids for ZFYVE1 Gene

Previous HGNC Symbols for ZFYVE1 Gene

  • ZNFN2A1

Previous GeneCards Identifiers for ZFYVE1 Gene

  • GC14M067231
  • GC14M071426
  • GC14M072505
  • GC14M073436
  • GC14M053602

Summaries for ZFYVE1 Gene

Entrez Gene Summary for ZFYVE1 Gene

  • The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for ZFYVE1 Gene

ZFYVE1 (Zinc Finger FYVE-Type Containing 1) is a Protein Coding gene. Among its related pathways are Autophagy. GO annotations related to this gene include phosphatidylinositol-3,4,5-trisphosphate binding and phosphatidylinositol-3,4-bisphosphate binding.

Gene Wiki entry for ZFYVE1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFYVE1 Gene

Genomics for ZFYVE1 Gene

Regulatory Elements for ZFYVE1 Gene

Enhancers for ZFYVE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F072960 1.3 Ensembl ENCODE 10.3 +65.1 65073 2.4 ATF1 ZNF133 ARID4B DMAP1 GLI4 ZNF2 ZNF48 YY1 ZNF302 FOS ELMSAN1 RBM25 LOC101928123 DCAF4 LOC100420966 ZFYVE1 GC14P072963
GH14F073057 1.1 ENCODE 11.2 -31.4 -31413 3.0 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 FOS LOC101928123 RBM25 ZFYVE1 ELMSAN1 PAPLN DCAF4 PSEN1 ACOT1 LOC105370560
GH14F073135 1 ENCODE 9.7 -109.8 -109818 2.4 HDGF PKNOX1 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 BRCA1 ELK1 RBM25 ELMSAN1 LOC100420966 LOC101928123 PNMA1 LIN52 PAPLN ZFYVE1 DCAF4 ACOT1
GH14F072924 1.1 ENCODE 6 +101.0 100969 3.6 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 FOS DCAF4 LOC100420966 PSEN1 LOC101928123 RBM25 ELMSAN1 ZFYVE1 HEATR4 DPF3
GH14F073140 0.5 Ensembl 10 -113.9 -113889 0.6 RAD51 ZNF585B EGR2 PAPLN ZFYVE1 PSEN1 ENSG00000259109
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFYVE1 on UCSC Golden Path with GeneCards custom track

Promoters for ZFYVE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZFYVE1 Gene

72,969,445 bp from pter
73,027,212 bp from pter
57,768 bases
Minus strand

Genomic View for ZFYVE1 Gene

Genes around ZFYVE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFYVE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFYVE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFYVE1 Gene

Proteins for ZFYVE1 Gene

  • Protein details for ZFYVE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger FYVE domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • J3KNL9
    • Q8WYX7
    • Q96K57
    • Q9BXP9
    • Q9HCI3

    Protein attributes for ZFYVE1 Gene

    777 amino acids
    Molecular mass:
    87176 Da
    Quaternary structure:
    • Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger.
    • Sequence=AAL55826.1; Type=Frameshift; Positions=480; Evidence={ECO:0000305}; Sequence=BAB13415.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55085.1; Type=Erroneous termination; Positions=760; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFYVE1 Gene


neXtProt entry for ZFYVE1 Gene

Post-translational modifications for ZFYVE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFYVE1 Gene

Domains & Families for ZFYVE1 Gene

Gene Families for ZFYVE1 Gene

Protein Domains for ZFYVE1 Gene

Suggested Antigen Peptide Sequences for ZFYVE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 FYVE-type zinc fingers.
  • Contains 2 FYVE-type zinc fingers.
genes like me logo Genes that share domains with ZFYVE1: view

Function for ZFYVE1 Gene

Gene Ontology (GO) - Molecular Function for ZFYVE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19389623
GO:0005545 1-phosphatidylinositol binding IDA 11256955
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 11804589
GO:0008270 zinc ion binding NAS 11739631
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA 11804589
genes like me logo Genes that share ontologies with ZFYVE1: view

Phenotypes for ZFYVE1 Gene

genes like me logo Genes that share phenotypes with ZFYVE1: view

Animal Model Products

miRNA for ZFYVE1 Gene

miRTarBase miRNAs that target ZFYVE1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFYVE1 Gene

Localization for ZFYVE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFYVE1 Gene

Golgi apparatus, Golgi stack. Endoplasmic reticulum. Note=Resides predominantly in the cisternal stacks of the Golgi. Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFYVE1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for ZFYVE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IDA 23455425
GO:0005776 autophagosome IDA 22456507
GO:0005783 endoplasmic reticulum IEA,IDA 11739631
GO:0005794 Golgi apparatus IEA --
GO:0005795 Golgi stack IEA,IDA 11256955
genes like me logo Genes that share ontologies with ZFYVE1: view

Pathways & Interactions for ZFYVE1 Gene

SuperPathways for ZFYVE1 Gene

SuperPathway Contained pathways
1 Autophagy
genes like me logo Genes that share pathways with ZFYVE1: view

Pathways by source for ZFYVE1 Gene

1 R&D Systems pathway for ZFYVE1 Gene

Gene Ontology (GO) - Biological Process for ZFYVE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009267 cellular response to starvation IDA 25578879
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0016236 macroautophagy IDA 25578879
genes like me logo Genes that share ontologies with ZFYVE1: view

No data available for SIGNOR curated interactions for ZFYVE1 Gene

Transcripts for ZFYVE1 Gene

Unigene Clusters for ZFYVE1 Gene

Zinc finger, FYVE domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFYVE1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP6: -

Relevant External Links for ZFYVE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFYVE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFYVE1 Gene

Protein differential expression in normal tissues from HIPED for ZFYVE1 Gene

This gene is overexpressed in Testis (11.1), Retina (10.4), and Spinal cord (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFYVE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFYVE1 Gene:


SOURCE GeneReport for Unigene cluster for ZFYVE1 Gene:


mRNA Expression by UniProt/SwissProt for ZFYVE1 Gene:

Tissue specificity: Isoform 1 is expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Isoform 1 and isoform 2 are highly expressed in heart. Isoform 2 is also detected in the testis.
genes like me logo Genes that share expression patterns with ZFYVE1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZFYVE1 Gene

Orthologs for ZFYVE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFYVE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFYVE1 34 35
  • 99.44 (n)
(Monodelphis domestica)
Mammalia ZFYVE1 35
  • 95 (a)
(Canis familiaris)
Mammalia ZFYVE1 34 35
  • 92.41 (n)
(Bos Taurus)
Mammalia ZFYVE1 34 35
  • 91.72 (n)
(Mus musculus)
Mammalia Zfyve1 34 16 35
  • 90.18 (n)
(Rattus norvegicus)
Mammalia Zfyve1 34
  • 89.45 (n)
(Ornithorhynchus anatinus)
Mammalia ZFYVE1 35
  • 64 (a)
(Gallus gallus)
Aves ZFYVE1 34 35
  • 80.84 (n)
(Anolis carolinensis)
Reptilia ZFYVE1 35
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zfyve1 34
  • 74.09 (n)
Str.6293 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16326 34
(Danio rerio)
Actinopterygii ZFYVE1 35
  • 76 (a)
zfyve1 34
  • 69.37 (n)
Dr.18806 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002036 34
  • 55.03 (n)
Species where no ortholog for ZFYVE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFYVE1 Gene

Gene Tree for ZFYVE1 (if available)
Gene Tree for ZFYVE1 (if available)

Paralogs for ZFYVE1 Gene Pseudogenes for ZFYVE1 Gene

genes like me logo Genes that share paralogs with ZFYVE1: view

No data available for Paralogs for ZFYVE1 Gene

Variants for ZFYVE1 Gene

Sequence variations from dbSNP and Humsavar for ZFYVE1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1007934 -- 72,996,771(+) cgtgc(A/G)gtcgc intron-variant
rs10130581 -- 72,979,569(+) GAATC(A/G)CTTGA intron-variant
rs10133784 -- 73,003,328(+) TGGGA(C/T)TATAG intron-variant
rs10134432 -- 73,003,816(+) ATGCC(A/G)GCTGC intron-variant
rs10138468 -- 72,999,755(+) TCATC(C/T)GCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFYVE1 Gene

Variant ID Type Subtype PubMed ID
esv3634896 CNV loss 21293372
esv3634897 CNV loss 21293372
esv3634898 CNV loss 21293372
nsv1035460 CNV gain 25217958
nsv1048734 CNV gain 25217958
nsv1049819 CNV gain 25217958
nsv1116032 CNV deletion 24896259
nsv1122912 CNV deletion 24896259
nsv1348 CNV deletion 18451855
nsv565050 CNV gain 21841781
nsv983842 CNV duplication 23825009

Variation tolerance for ZFYVE1 Gene

Residual Variation Intolerance Score: 8.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFYVE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFYVE1 Gene

Disorders for ZFYVE1 Gene

Relevant External Links for ZFYVE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZFYVE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFYVE1 Gene

Publications for ZFYVE1 Gene

  1. Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library. (PMID: 11024279) Derubeis A.R. … Fisher L.W. (Gene 2000) 2 3 4 22 64
  2. Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi. (PMID: 11256955) Cheung P.C.F. … Lucocq J.M. (Biochem. J. 2001) 2 3 4 64
  3. TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells. (PMID: 22178386) Tomar D. … Singh R. (Biochim. Biophys. Acta 2012) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ZFYVE1 Gene

Sources for ZFYVE1 Gene

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