ZFY Gene
protein-coding GIFtS: 51
GCID: GC0YP002846
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|
zinc finger protein, Y-linked
| |
Aliases
for ZFY gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein, Y-Linked1 2 | | ZNF9111 2 | | Zinc Finger Y-Chromosomal Protein2 |
Export aliases for ZFY gene to outside databasesPrevious GC identifers: GC0YP002729 GC0YP002448 GC0YP000155 |
Summaries
for ZFY gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZFY:
This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once acandidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: ZFY_HUMAN, P08048Function: Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'
Gene Wiki entry for ZFY
|
Genomic Views
for ZFY gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000024.9 NT_011896.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZFY gene promoter:
AhR Pax-5 Egr-1 Olf-1 Pax-4a Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZFY
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFY |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Yp11.3 Ensembl cytogenetic band: Yp11.31 HGNC cytogenetic band: Yp11.3ZFY Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YP002846: view genomic region
(about GC identifiers)
Start:
|
2,803,112 bp from pter |
End:
|
2,850,547 bp from pter |
Size:
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47,436 bases |
Orientation:
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plus strand |
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Proteins
for ZFY gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZFY_HUMAN, P08048 (See
protein sequence)Recommended Name: Zinc finger Y-chromosomal protein Size: 801 amino acids; 90505 Da
Subcellular location: Nucleus
Caution: Was originally thought to be the testis determining factor (TDF)
5 PDB 3D structures from  and Proteopedia  for ZFY:1KLR (3D)
1KLS (3D)
1XRZ (3D)
5ZNF (3D)
7ZNF (3D)
Secondary accessions: B4DVF7 Q14021 Q15558 Q1RME9 Q24JR0 Q96TF3Alternative splicing: 3 isoforms: P08048-1 P08048-2 P08048-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZFY: NX_P08048
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P08048
ZFY Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001138747.1 NP_001138748.1 NP_003402.2
ENSEMBL proteins: ENSP00000372525 ENSP00000388814 ENSP00000402502 ENSP00000155093 ENSP00000393908
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZFY for ontologies About GeneDecksing
ZFY Antibody Products:
Assay Products for ZFY: |
Protein
Domains /
Families
for ZFY gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZFY for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P08048ProtoNet protein and cluster: P08048 2 Blocks protein families: IPB006794 Zfx / Zfy transcription activation region IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZFY_HUMAN, P08048Domain: The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and13Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamilySimilarity: Contains 13 C2H2-type zinc fingers |
Function
for ZFY gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZFY_HUMAN, P08048Function: Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' Genatlas biochemistry entry for ZFY:zinc finger protein,Y-linked
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFY (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFY (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFY |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZFY for ontologies About GeneDecksing
|
Pathways & Interactions
for ZFY gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFY
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZFY (P080483 ENSP000001550934) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZFY for ontologies About GeneDecksing
|
Drugs & Compounds
for ZFY gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ZFY for compounds About GeneDecksing
 Browse Tocris compounds for ZFY
1 HMDB Compound for ZFY About this table
1 DrugBank Compound for ZFY About this table
2 Novoseek chemical compound relationships for ZFY gene About this table
Search CenterWatch for drugs/clinical trials and news about ZFY
|
Transcripts
for ZFY gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZFY gene (3 alternative transcripts): NM_001145275.1 NM_001145276.1 NM_003411.3 Unigene Cluster for ZFY: Zinc finger protein, Y-linked Hs.522845 [show with all ESTs]Unigene Representative Sequence: NM_0034117 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000383052(uc010nwd.1) ENST00000443793 ENST00000469869 ENST00000478783
ENST00000431102(uc011nan.2) ENST00000155093(uc004fqj.3) ENST00000449237(uc010nwe.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFY (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFY (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ZFY (NM_001145275) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZFY | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFY |
Additional cDNA sequence: AK301061.1 AK310553.1 AL137603.1 BC114526.1 BC114960.1 L10393.1 M30607.1 3 DOTS entries: DT.404404 DT.40249401 DT.75124539 24/32 AceView cDNA sequences (see all 32): AI523646 AW778852 AI261592 AA902815 CB990394 NM_003411 AL137603 AW675065 AA766898 BU570528 BE675633 BQ950184 CD652103 BG177200 AW674333 BM717872 BF592062 BI600096 AI763177 L10393 BU569066 BP364622 AI831955 M30607
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZFY About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 |
|---|
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| SP1: | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZFY
|
Expression
for ZFY gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZFY expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZFY Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZFY
SOURCE GeneReport for Unigene cluster: Hs.522845
SABiosciences Custom PCR Arrays for ZFY
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFY
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZFY | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFY | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFY | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFY |
Orthologs
for ZFY gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZFY gene from 3/7 species (see all 7) About this table
ENSEMBL Gene Tree for ZFY (if available)
TreeFam Gene Tree for ZFY (if available) |
Paralogs
for ZFY gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZFY gene
- ZNF6392 ZNF7112 ZFX2
10 SIMAP similar genes for ZFY using alignment to 2 protein entries: ZFY_HUMAN (see all proteins):ZFX ZNF711 ZNF ZNF137P ZNF345 ZNF419
ZNF501 ZNF558 ZNF585B ZFP3
ZFY for paralogs About GeneDecksing
|
Genomic Variants
for ZFY gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr Y pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZFY (2803112 - 2850547 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZFY: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFY |
|
Disorders
/ Diseases
for ZFY gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZFY for disorders About GeneDecksing
OMIM gene information: 490000
OMIM disorders: --
12  diseases for ZFY: About MalaCardsxy sex reversal sex reversal gonadal dysgenesis campomelic dysplasia
gonadoblastoma pseudohermaphroditism turner syndrome azoospermia
hermaphroditism prostate adenocarcinoma adenocarcinoma prostatitis
4 diseases from the University of Copenhagen DISEASES database for ZFY:Gonadoblastoma Turner syndrome Hermaphroditism Azoospermia Export disorders for ZFY gene to outside databases
|
Publications
for ZFY gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZFY gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with ZFY) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY. (PubMed id 2041734)1, 2, 9 North M....Ferguson-Smith M.A. (1991)
- Comparison of human ZFY and ZFX transcripts. (PubMed id 2308929)1, 2, 9 Palmer M.S.... Goodfellow P.N. (1990)
- Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans. (PubMed id 10779541)1, 2, 9 Erlandsson R.... Paabo S. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (2003)
- Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for 'jumping-linker' DNA recognition. (PubMed id 1849423)1, 2 Kochoyan M....Weiss M.A. (1991)
- Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition. (PubMed id 1854720)1, 2 Kochoyan M.... Weiss M.A. (1991)
- Mapping the human ZFX locus to Xp21.3 by in situ hybridization. (PubMed id 2497060)1, 3 Muller G. and Schempp W. (1989)
- The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues. (PubMed id 2511751)1, 2 Lau Y.-F.C. and Chan K. (1989)
- Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9. (PubMed id 2498838)1, 2 Affara N.A.... Ferguson-Smith M.A. (1989)
|
External Searches for ZFY gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZFY gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZFY gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZFY gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZFY | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZFY gene:
Search GeneIP for patents involving ZFY
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZFY gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZFY | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFY | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFY | | | OriGene Protein Over-expression Lysate for ZFY | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZFY | | OriGene 3'-UTR Clone for ZFY | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFY | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFY | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZFY | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFY | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFY | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFY | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFY | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFY |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZFY |
| |  |  |  |  | | | | |
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 | | | ZFY Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFY |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFY |
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