Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFX Gene

protein-coding   GIFtS: 52
GCID: GC0XP024167

Zinc Finger Protein, X-Linked

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein, X-Linked1 2
ZNF9262
X-Linked Zinc Finger Protein2
Zinc Finger X-Chromosomal Protein2

External Ids:    HGNC: 128691   Entrez Gene: 75432   Ensembl: ENSG000000058897   OMIM: 3149805   UniProtKB: P170103   

Export aliases for ZFX gene to outside databases

Previous GC identifers: GC0XP022985 GC0XP022816 GC0XP023369 GC0XP023531 GC0XP023529 GC0XP023927 GC0XP024077 GC0XP021912


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZFX Gene:
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member
of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional
activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13
C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was
required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for
growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding
different isoforms have been identified, but the full-length nature of some variants has not been determined.
(provided by RefSeq, May 2010)

GeneCards Summary for ZFX Gene: 
ZFX (zinc finger protein, X-linked) is a protein-coding gene. Diseases associated with ZFX include x-linked disease, and retinoschisis. GO annotations related to this gene include transcription coactivator activity and DNA binding. An important paralog of this gene is ZNF639.

UniProtKB/Swiss-Prot: ZFX_HUMAN, P17010
Function: Probable transcriptional activator

Gene Wiki entry for ZFX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167197.1  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFX gene promoter:
         AhR   Spz1   POU3F1   FOXD3   Pax-4a   Gfi-1   Arnt   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFX promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.3   Ensembl cytogenetic band:  Xp22.11   HGNC cytogenetic band: Xp22.1-p21.3

ZFX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFX gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP024167:  view genomic region     (about GC identifiers)

Start:
24,167,290 bp from pter      End:
24,234,372 bp from pter
Size:
67,083 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZFX_HUMAN, P17010 (See protein sequence)
Recommended Name: Zinc finger X-chromosomal protein  
Size: 805 amino acids; 90522 Da
Subcellular location: Nucleus
Secondary accessions: O43668 Q8WYJ8
Alternative splicing: 2 isoforms:  P17010-1   P17010-2   

Explore the universe of human proteins at neXtProt for ZFX: NX_P17010

Explore proteomics data for ZFX at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17010

  • ZFX Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFX Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001171555.1  NP_001171556.1  NP_001171557.1  NP_001171566.1  NP_003401.2  

    ENSEMBL proteins: 
     ENSP00000411637   ENSP00000416298   ENSP00000368475   ENSP00000304985   ENSP00000343384  
     ENSP00000368486   ENSP00000441382   ENSP00000438233  

    Human Recombinant Protein Products for ZFX: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ZFX
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ZFX
    GenScript Custom Purified and Recombinant Proteins Services for ZFX
    Novus Biologicals ZFX Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZFX 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    ZFX for ontologies           About GeneDecksing



    ZFX Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ZFX 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZFX
    GenScript Custom Superior Antibodies Services for ZFX
    Novus Biologicals ZFX Antibody
    Abcam antibodies for ZFX
    Cloud-Clone Corp. Antibodies for ZFX 
    ThermoFisher Antibodies for ZFX
    LSBio Antibodies in human, mouse, rat for ZFX 

    Assay Products for ZFX: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZFX
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZFX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZFX 
    Cloud-Clone Corp. CLIAs for ZFX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR006794 Transcrp_activ_Zfx/Zfy-dom
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17010

    ProtoNet protein and cluster: P17010

    2 Blocks protein domains:
    IPB006794 Zfx / Zfy transcription activation region
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZFX_HUMAN, P17010
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily
    Similarity: Contains 13 C2H2-type zinc fingers


    ZFX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFX_HUMAN, P17010
    Function: Probable transcriptional activator

         Genatlas biochemistry entry for ZFX:
    zinc finger protein,X-linked,putative transcription activator with alternative isoforms,575 and 804 AA,escaping
    inactivation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003713transcription coactivator activity TAS2105457
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZFX for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ZFX:
     Decreased viability  Increased G1 DNA content  Increased cell size  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Zfx):
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  immune system 
     mortality/aging  nervous system  reproductive system 

    ZFX for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ZFX: Zfxtm1.2Reiz Zfxtm1Dcp

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFX 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZFX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZFX 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZFX 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFX
    8/126 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFX (see all 126):
    hsa-miR-124* hsa-miR-411* hsa-miR-579 hsa-miR-520e hsa-miR-1321 hsa-miR-3653 hsa-miR-138-2* hsa-miR-4275
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZFX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFX

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZFX
    Sirion Biotech Customized adenovirus for overexpression of ZFX

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ZFX (see all 21)
    OriGene ORF clones in mouse, rat for ZFX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): ZFX (NM_001178095)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFX
    Sirion Biotech Customized lentivirus for stable overexpression of ZFX 
                         Customized lentivirus expression plasmids for stable overexpression of ZFX 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZFX
    Search LifeMap BioReagents cell lines for ZFX
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFX


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFX

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZFX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZFX for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFX

    2 Novoseek inferred chemical compound relationships for ZFX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 61.3 11 8657576 (3), 9820590 (1), 9486796 (1), 15060604 (1) (see all 8)
    glucose 6-phosphate 37.9 1 15125640 (1)

    Search CenterWatch for drugs/clinical trials and news about ZFX

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFX gene (5 alternative transcripts): 
    NM_001178084.1  NM_001178085.1  NM_001178086.1  NM_001178095.1  NM_003410.3  

    Unigene Cluster for ZFX:

    Zinc finger protein, X-linked
    Hs.336681  [show with all ESTs]
    Unigene Representative Sequence: NM_001178085
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497813 ENST00000428571 ENST00000419690 ENST00000379177(uc004dbd.2 uc004dbf.3 uc011mjv.2)
    ENST00000304543 ENST00000459724 ENST00000480195 ENST00000338565(uc010nfy.1)
    ENST00000474385 ENST00000379188(uc004dbe.3 uc022bua.1) ENST00000540034
    ENST00000539115(uc010nfx.2 uc010nfz.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFX
    8/126 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFX (see all 126):
    hsa-miR-124* hsa-miR-411* hsa-miR-579 hsa-miR-520e hsa-miR-1321 hsa-miR-3653 hsa-miR-138-2* hsa-miR-4275
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZFX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFX
    Clone
    Products:
         
    OriGene clones in human, mouse for ZFX (see all 21)
    OriGene ORF clones in mouse, rat for ZFX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): ZFX (NM_001178095)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFX
    Sirion Biotech Customized lentivirus for stable overexpression of ZFX 
                         Customized lentivirus expression plasmids for stable overexpression of ZFX 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZFX
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFX
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFX
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFX

    Additional mRNA sequence: 

    AB209892.1 AF454950.1 AF505615.1 AF505616.1 AF505617.1 AF505618.1 AF505619.1 AY072770.1 
    BC030756.2 BC136308.1 BC136309.1 M30608.1 X59738.1 X59739.1 X59740.1 

    11 DOTS entries:

    DT.92424037  DT.121299582  DT.91754275  DT.101976110  DT.121299573  DT.95266567  DT.95095924  DT.95264329 
    DT.100751052  DT.100751054  DT.313255 

    24/144 AceView cDNA sequences (see all 144):

    AI695183 BM699597 M30608 CD722604 AA343391 AA983930 NM_003410 AF505618 
    BX281676 BU615694 BM985213 BP357333 X59740 AA676699 AL042461 BQ022250 
    CB112763 CB991583 AW963042 BX113165 AF505616 AU185591 AI248153 AI800637 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ZFX (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9
    SP1:              -                                   -     -     -                                       
    SP2:              -     -                             -     -     -                                       
    SP3:              -     -     -                       -     -     -                                       
    SP4:                                                  -     -     -                                       
    SP5:                                                  -                                                   


    ECgene alternative splicing isoforms for ZFX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFX expression in normal human tissues (normalized intensities)      ZFX embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTTTCCTA
    ZFX Expression
    About this image


    ZFX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             cd49a+ cells   
     
     Kidney (Urinary System)
             renal vesicle e12.5   
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Skeletal Muscle (Muscoskeletal System)
             deltoid muscle   
     
     Thyroid (Endocrine System)

    See ZFX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFX

    SOURCE GeneReport for Unigene cluster: Hs.336681
        SABiosciences Custom PCR Arrays for ZFX
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZFX
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFX
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFX
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZFX gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfx1 , 5 zinc finger protein X-linked1, 5 91.98(n)1
    95.86(a)1
      X (41.48 cM)5
    227641  NM_011768.21  NP_035898.21 
     940746315 
    chicken
    (Gallus gallus)
    Aves ZFX1 zinc finger protein, X-linked 84.55(n)
    91.16(a)
      418596  XM_416795.3  XP_416795.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    82(a)
    1 → many
    3(125817728-125832276)
    African clawed frog
    (Xenopus laevis)
    Amphibia XZFY-12 X.laevis XZFY-1 mRNA 77.37(n)    X68024.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zfx1 zinc finger protein, X-linked 63.93(n)
    63.08(a)
      560346  XM_683750.5  XP_688842.3 


    ENSEMBL Gene Tree for ZFX (if available)
    TreeFam Gene Tree for ZFX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFX gene
    ZNF6392  ZFY2  ZNF7112  
    18/238 SIMAP similar genes for ZFX using alignment to 17 protein entries:     ZFX_HUMAN (see all proteins) (see all similar genes):
    ZFY    CNOT2    ZNF654    ZNF711    ZNF536    ZNF55
    ZNF72    HZF16    PRDM15    ZNF298    ZNF516    ZNF891
    ZFS-2    ZNF    ZNF550    IKZF4    ZFAT    ZNF217

    ZFX for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1001 SNPs in ZFX are shown (see all 1001)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901900171,2
    --24080953(+) GGGAAC/GCTGGC 2 -- us2k10--------
    rs1403729531,2
    --24081012(+) CTTAAA/TCGCTG 4 -- us2k10--------
    rs1427078791,2
    C--24081141(+) GCCTGA/GCCAAC 5 -- us2k10--------
    rs65263731,2
    C,F,A,H--24081359(+) TTTTTT/GATTGA 5 -- us2k114Minor allele frequency- G:0.50NS EA NA WA CSA 1863
    rs1824141251,2
    --24081478(+) TTGAAA/TGGAAA 5 -- us2k10--------
    rs1871074551,2
    --24081535(+) ATCATC/TCAGTG 5 -- us2k10--------
    rs1914856501,2
    --24081707(+) ACCAGC/TATACT 5 -- us2k10--------
    rs1394479851,2
    C--24081808(+) TAATGC/TAAAGA 5 -- us2k10--------
    rs734741401,2
    C,F--24081809(+) AATGTG/AAAGAC 5 -- us2k11Minor allele frequency- A:0.50WA 2
    rs37616401,2
    C,F,H--24081964(-) TGGGAG/CAGAAG 5 -- us2k1 trp34Minor allele frequency- C:0.01NS EA 418

    HapMap Linkage Disequilibrium report for ZFX (24167290 - 24234372 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZFX:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674864CNV Deletion23128226
    nsv515192CNV Gain21397061
    dgv504n21CNV Gain19592680
    nsv818019CNV Gain17921354
    nsv524256CNV Gain19592680
    nsv515191CNV Gain21397061


    Locus Specific Mutation Databases (LSDB): ZFX
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZFX
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 314980    OMIM disorders: --

    10 diseases for ZFX:    About MalaCards
    x-linked disease    retinoschisis    premature ovarian failure    prostate adenocarcinoma
    azoospermia    malignant glioma    laryngitis    adenocarcinoma
    gastric cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ZFX:
    Retinoschisis

    ZFX for disorders           About GeneDecksing


    Export disorders for ZFX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFX gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with ZFX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY. (PubMed id 2041734)1, 2, 9 North M....Ferguson-Smith M.A. (1991)
    2. Comparison of human ZFY and ZFX transcripts. (PubMed id 2308929)1, 2 Palmer M.S.... Goodfellow P.N. (1990)
    3. Putative transcription activator with alternative isoforms encoded by human ZFX gene. (PubMed id 2512506)1, 2 Schneider-Gaedicke A.... Page D.C. (1989)
    4. ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation. (PubMed id 2500252)1, 2 Schneider-Gaedicke A....Page D.C. (1989)
    5. Cloning and comparative analysis of the bovine, porcine, and equine sex chromosome genes ZFX and ZFY. (PubMed id 15060604)1, 9 Poloumienko A. (2004)
    6. Paternal transcripts for glucose-6-phosphate dehydrogenase and adenosine deaminase are first detectable in the human preimplantation embryo at the three- to four-cell stage. (PubMed id 9364438)1, 9 Taylor D.M....Handyside A.H. (1997)
    7. ZFX regulates glioma cell proliferation and survival i n vitro and in vivo. (PubMed id 23322077)1 Zhu Z....Zheng J. (2013)
    8. Knockdown of ZFX inhibits gastric cancer cell growth i n vitro and in vivo via downregulating the ERK-MAPK pathway. (PubMed id 23587796)1 Wu S....Fang J.Y. (2013)
    9. Knockdown of zinc finger protein, X-linked (ZFX) inhib its cell proliferation and induces apoptosis in human laryngeal squamous cell ca rcinoma. (PubMed id 22009483)1 Fang J....Han D. (2012)
    10. Differential expression of ZFX gene in gastric cancer. (PubMed id 22357206)1 Nikpour P....Haghjooy-Javanmard S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7543 HGNC: 12869 AceView: ZFX Ensembl:ENSG00000005889 euGenes: HUgn7543
    ECgene: ZFX H-InvDB: ZFX

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFX gene:
    Search GeneIP for patents involving ZFX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZFX  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ZFX  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZFX  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZFX   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZFX   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZFX   OriGene Custom Protein Services for ZFX  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZFX
     QIAGEN SeqTarget long-range PCR primers for resequencing ZFX
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFX
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFX
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFX
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFX
     GenScript Custom Purified and Recombinant Proteins Services for ZFX GenScript cDNA clones with any tag delivered in your preferred vector for ZFX
     GenScript Custom Assay Services for ZFX GenScript Custom Superior Antibodies Services for ZFX
     GenScript Custom overexpressing Cell Line Services for ZFX CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for ZFX 

     Regulatory tfbs in ZFX promoter
     Search Chromatin IP Primers for ZFX
     RT2 qPCR Primer Assay in human, mouse, rat ZFX
     GNC Network for ZFX
     SABiosciences Custom PCR Arrays for ZFX
     Search Tocris compounds for ZFX
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ZFX antibodies
     ZFX lysates
     Antibodies for ZFX
     See all of Abcam's Antibodies, Kits and Proteins for ZFX
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ZFX
     Antibodies for ZFX
     ELISAs for ZFX
     CLIAs for ZFX
     Search LifeMap BioReagents cell lines for ZFX
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFX
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ZFX
     SwitchGear Promoter luciferase reporter plasmids for ZFX
     ThermoFisher Antibodies for ZFX
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFX
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFX
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZFX
    Customized:
     lentivirus for stable overexpression of ZFX
     lentivirus expression plasmids for stable overexpression of ZFX
     adenovirus for overexpression of ZFX
     LSBio Antibodies in human, mouse, rat for ZFX
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZFX gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4