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ZFX Gene

protein-coding   GIFtS: 55
GCID: GC0XP024167

Zinc Finger Protein, X-Linked

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein, X-Linked1 2
ZNF9262
X-Linked Zinc Finger Protein2
Zinc Finger X-Chromosomal Protein2

External Ids:    HGNC: 128691   Entrez Gene: 75432   Ensembl: ENSG000000058897   OMIM: 3149805   UniProtKB: P170103   

Export aliases for ZFX gene to outside databases

Previous GC identifers: GC0XP022985 GC0XP022816 GC0XP023369 GC0XP023531 GC0XP023529 GC0XP023927 GC0XP024077 GC0XP021912


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZFX Gene:
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member
of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional
activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13
C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was
required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for
growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding
different isoforms have been identified, but the full-length nature of some variants has not been determined.
(provided by RefSeq, May 2010)

GeneCards Summary for ZFX Gene:
ZFX (zinc finger protein, X-linked) is a protein-coding gene. Diseases associated with ZFX include x-linked disease, and retinoschisis. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is ZNF639.

UniProtKB/Swiss-Prot: ZFX_HUMAN, P17010
Function: Probable transcriptional activator

Gene Wiki entry for ZFX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFX gene promoter:
         AhR   Spz1   POU3F1   FOXD3   Pax-4a   Gfi-1   Arnt   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFX promoter sequence
   Search Chromatin IP Primers for ZFX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.3   Ensembl cytogenetic band:  Xp22.11   HGNC cytogenetic band: Xp22.1-p21.3

ZFX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFX gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP024167:  view genomic region     (about GC identifiers)

Start:
24,167,290 bp from pter      End:
24,234,372 bp from pter
Size:
67,083 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZFX_HUMAN, P17010 (See protein sequence)
Recommended Name: Zinc finger X-chromosomal protein  
Size: 805 amino acids; 90522 Da
Secondary accessions: O43668 Q8WYJ8
Alternative splicing: 2 isoforms:  P17010-1   P17010-2   

Explore the universe of human proteins at neXtProt for ZFX: NX_P17010

Explore proteomics data for ZFX at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys715
  • Modification sites at PhosphoSitePlus

  • See ZFX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001171555.1  NP_001171556.1  NP_001171557.1  NP_001171566.1  NP_003401.2  

    ENSEMBL proteins: 
     ENSP00000411637   ENSP00000416298   ENSP00000368475   ENSP00000304985   ENSP00000343384  
     ENSP00000368486   ENSP00000441382   ENSP00000438233  

    ZFX Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ZFX
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    Novus Biologicals ZFX Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ZFX

    ZFX Antibody Products:

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    Cloud-Clone Corp. ELISAs for ZFX
    Cloud-Clone Corp. CLIAs for ZFX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR006794 Transcrp_activ_Zfx/Zfy-dom
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17010

    ProtoNet protein and cluster: P17010

    2 Blocks protein domains:
    IPB006794 Zfx / Zfy transcription activation region
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZFX_HUMAN, P17010
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily
    Similarity: Contains 13 C2H2-type zinc fingers


    ZFX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFX_HUMAN, P17010
    Function: Probable transcriptional activator

         Genatlas biochemistry entry for ZFX:
    zinc finger protein,X-linked,putative transcription activator with alternative isoforms,575 and 804 AA,escaping
    inactivation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003713transcription coactivator activity TAS2105457
    GO:0046872metal ion binding IEA--
         
    ZFX for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ZFX:
     Decreased viability  Increased G1 DNA content  Increased cell size  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Zfx):
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  immune system 
     mortality/aging  nervous system  reproductive system 

    ZFX for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ZFX: Zfxtm1.2Reiz Zfxtm1Dcp

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZFX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZFX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZFX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZFX

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  AGGCCTGG 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZFX:
    hsa-mir-484 (MIRT042023), hsa-mir-98-5p (MIRT027627), hsa-mir-101-3p (MIRT027367)

    Block miRNA regulation of human, mouse, rat ZFX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFX (see all 126):
    hsa-miR-124* hsa-miR-411* hsa-miR-579 hsa-miR-520e hsa-miR-1321 hsa-miR-3653 hsa-miR-138-2* hsa-miR-4275
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZFX

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ZFX

    Clone
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    OriGene clones in human, mouse for ZFX (see all 24)
    OriGene ORF clones in mouse, rat for ZFX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): ZFX (NM_001178095)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFX

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ZFX
    Browse ESI BIO Cell Lines and PureStem Progenitors for ZFX 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZFX_HUMAN, P17010: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZFX for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFX
    Interactions:

        GeneGlobe Interaction Network for ZFX

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007281germ cell development ----
    GO:0007283spermatogenesis IEA--

    ZFX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFX

    2 Novoseek inferred chemical compound relationships for ZFX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 61.3 11 8657576 (3), 9820590 (1), 9486796 (1), 15060604 (1) (see all 8)
    glucose 6-phosphate 37.9 1 15125640 (1)



    ZFX for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZFX gene (5 alternative transcripts): 
    NM_001178084.1  NM_001178085.1  NM_001178086.1  NM_001178095.1  NM_003410.3  

    Unigene Cluster for ZFX:

    Zinc finger protein, X-linked
    Hs.336681  [show with all ESTs]
    Unigene Representative Sequence: NM_001178085
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497813 ENST00000428571 ENST00000419690 ENST00000379177(uc004dbd.2 uc004dbf.3 uc011mjv.2)
    ENST00000304543 ENST00000459724 ENST00000480195 ENST00000338565(uc010nfy.1)
    ENST00000474385 ENST00000379188(uc004dbe.3 uc022bua.1) ENST00000540034
    ENST00000539115(uc010nfx.2 uc010nfz.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat ZFX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFX (see all 126):
    hsa-miR-124* hsa-miR-411* hsa-miR-579 hsa-miR-520e hsa-miR-1321 hsa-miR-3653 hsa-miR-138-2* hsa-miR-4275
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZFX
    Predesigned siRNA for gene silencing in human, mouse, rat ZFX
    Clone
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    OriGene clones in human, mouse for ZFX (see all 24)
    OriGene ORF clones in mouse, rat for ZFX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): ZFX (NM_001178095)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFX
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZFX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZFX
      QuantiTect SYBR Green Assays in human, mouse, rat ZFX
      QuantiFast Probe-based Assays in human, mouse, rat ZFX

    Additional mRNA sequence: 

    AB209892.1 AF454950.1 AF505615.1 AF505616.1 AF505617.1 AF505618.1 AF505619.1 AY072770.1 
    BC030756.2 BC136308.1 BC136309.1 M30608.1 X59738.1 X59739.1 X59740.1 

    11 DOTS entries:

    DT.92424037  DT.121299582  DT.91754275  DT.101976110  DT.121299573  DT.95266567  DT.95095924  DT.95264329 
    DT.100751052  DT.100751054  DT.313255 

    Selected AceView cDNA sequences (see all 144):

    AI695183 NM_003410 M30608 AF505618 BM699597 BX281676 AA343391 AA983930 
    CD722604 BG615698 BM474395 AF454950 AI241571 BU615694 AL691932 BX280274 
    AW963042 BQ013794 AF505615 CB112763 BX089211 AI239880 BM747532 BM747640 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZFX (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9
    SP1:              -                                   -     -     -                                       
    SP2:              -     -                             -     -     -                                       
    SP3:              -     -     -                       -     -     -                                       
    SP4:                                                  -     -     -                                       
    SP5:                                                  -                                                   


    ECgene alternative splicing isoforms for ZFX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTTTCCTA
    ZFX Expression
    About this image


    ZFX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    ZFX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.336681
        Custom PCR Arrays for ZFX
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZFX gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfx1 , 5 zinc finger protein X-linked1, 5 91.81(n)1
    95.61(a)1
      X (41.48 cM)5
    227641  NM_011768.21  NP_035898.21 
     940746315 
    chicken
    (Gallus gallus)
    Aves ZFX1 zinc finger protein, X-linked 84.39(n)
    90.78(a)
      418596  XM_416795.4  XP_416795.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    82(a)
    1 → many
    3(125817728-125832276)
    African clawed frog
    (Xenopus laevis)
    Amphibia XZFY-12 X.laevis XZFY-1 mRNA 77.37(n)    X68024.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zfx1 zinc finger protein, X-linked 64.03(n)
    64.36(a)
      560346  XM_683750.6  XP_688842.3 


    ENSEMBL Gene Tree for ZFX (if available)
    TreeFam Gene Tree for ZFX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZFX gene
    ZNF6392  ZFY2  ZNF7112  
    Selected SIMAP similar genes for ZFX using alignment to 17 protein entries:     ZFX_HUMAN (see all proteins) (see all similar genes):
    ZFY    CNOT2    ZNF654    ZNF711    ZNF536    ZNF55
    ZNF72    HZF16    PRDM15    ZNF298    ZNF516    ZNF891
    ZFS-2    ZNF    ZNF550    IKZF4    ZFAT    ZNF217

    ZFX for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFX (see all 1001)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901900171,2
    --24080953(+) GGGAAC/GCTGGC 2 -- us2k10--------
    rs1403729531,2
    --24081012(+) CTTAAA/TCGCTG 4 -- us2k10--------
    rs1427078791,2
    C--24081141(+) GCCTGA/GCCAAC 5 -- us2k10--------
    rs65263731,2
    C,F,A,H--24081359(+) TTTTTT/GATTGA 5 -- us2k114Minor allele frequency- G:0.50NS EA NA WA CSA 1863
    rs1824141251,2
    --24081478(+) TTGAAA/TGGAAA 5 -- us2k10--------
    rs1871074551,2
    --24081535(+) ATCATC/TCAGTG 5 -- us2k10--------
    rs1914856501,2
    --24081707(+) ACCAGC/TATACT 5 -- us2k10--------
    rs1394479851,2
    C--24081808(+) TAATGC/TAAAGA 5 -- us2k10--------
    rs734741401,2
    C,F--24081809(+) AATGTG/AAAGAC 5 -- us2k11Minor allele frequency- A:0.50WA 2
    rs37616401,2
    C,F,H--24081964(-) TGGGAG/CAGAAG 5 -- us2k1 trp34Minor allele frequency- C:0.01NS EA 418

    HapMap Linkage Disequilibrium report for ZFX (24167290 - 24234372 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZFX:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674864CNV Deletion23128226
    nsv515192CNV Gain21397061
    dgv504n21CNV Gain19592680
    nsv818019CNV Gain17921354
    nsv524256CNV Gain19592680
    nsv515191CNV Gain21397061

    Locus Specific Mutation Databases (LSDB): ZFX

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZFX
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 314980    OMIM disorders: --

    12 diseases for ZFX:    
    About MalaCards
    x-linked disease    retinoschisis    premature ovarian failure    prostate adenocarcinoma
    azoospermia    malignant glioma    laryngeal squamous cell carcinoma    laryngitis
    adenocarcinoma    prostatitis    squamous cell carcinoma    lung cancer

    1 disease from the University of Copenhagen DISEASES database for ZFX:
    Retinoschisis

    ZFX for disorders           About GeneDecksing


    Export disorders for ZFX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFX gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with ZFX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY. (PubMed id 2041734)1, 2, 9 North M....Ferguson-Smith M.A. (Nucleic Acids Res. 1991)
    2. Comparison of human ZFY and ZFX transcripts. (PubMed id 2308929)1, 2 Palmer M.S.... Goodfellow P.N. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    3. Putative transcription activator with alternative isoforms encoded by human ZFX gene. (PubMed id 2512506)1, 2 Schneider-Gaedicke A.... Page D.C. (Nature 1989)
    4. ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation. (PubMed id 2500252)1, 2 Schneider-Gaedicke A....Page D.C. (Cell 1989)
    5. Cloning and comparative analysis of the bovine, porcine, and equine sex chromosome genes ZFX and ZFY. (PubMed id 15060604)1, 9 Poloumienko A. (Genome 2004)
    6. Paternal transcripts for glucose-6-phosphate dehydrogenase and adenosine deaminase are first detectable in the human preimplantation embryo at the three- to four-cell stage. (PubMed id 9364438)1, 9 Taylor D.M....Handyside A.H. (Mol. Reprod. Dev. 1997)
    7. Regulation of cell proliferation and migration in gallbladder cancer by zinc finger X-chromosomal protein. (PubMed id 23860324)1 Tan Z....Liu Y. (Gene 2013)
    8. ZFX regulates glioma cell proliferation and survival in vitro and in vivo. (PubMed id 23322077)1 Zhu Z....Zheng J. (J. Neurooncol. 2013)
    9. [Expression of zinc finger protein X-linked in childhood B lineage acute lymphoblastic leukemia]. (PubMed id 23866268)1 Wang Z....Jiang H. (Zhongguo Dang Dai Er Ke Za Zhi 2013)
    10. Knockdown of ZFX inhibits gastric cancer cell growth in vitro and in vivo via downregulating the ERK-MAPK pathway. (PubMed id 23587796)1 Wu S....Fang J.Y. (Cancer Lett. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7543 HGNC: 12869 AceView: ZFX Ensembl:ENSG00000005889 euGenes: HUgn7543
    ECgene: ZFX H-InvDB: ZFX

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZFX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFX gene:
    Search GeneIP for patents involving ZFX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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