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Aliases for ZFX Gene

Aliases for ZFX Gene

  • Zinc Finger Protein, X-Linked 2 3 5
  • Zinc Finger X-Chromosomal Protein 3
  • X-Linked Zinc Finger Protein 3
  • ZNF926 3

External Ids for ZFX Gene

Previous GeneCards Identifiers for ZFX Gene

  • GC0XP022985
  • GC0XP022816
  • GC0XP023369
  • GC0XP023531
  • GC0XP023529
  • GC0XP023927
  • GC0XP024077
  • GC0XP021912

Summaries for ZFX Gene

Entrez Gene Summary for ZFX Gene

  • This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]

GeneCards Summary for ZFX Gene

ZFX (Zinc Finger Protein, X-Linked) is a Protein Coding gene. Diseases associated with ZFX include Gallbladder Cancer and X-Linked Disease. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is ZFY.

UniProtKB/Swiss-Prot for ZFX Gene

  • Probable transcriptional activator.

Gene Wiki entry for ZFX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFX Gene

Genomics for ZFX Gene

Regulatory Elements for ZFX Gene

Enhancers for ZFX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZFX on UCSC Golden Path with GeneCards custom track

Promoters for ZFX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZFX Gene

24,148,934 bp from pter
24,216,255 bp from pter
67,322 bases
Plus strand

Genomic View for ZFX Gene

Genes around ZFX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFX Gene

Proteins for ZFX Gene

  • Protein details for ZFX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger X-chromosomal protein
    Protein Accession:
    Secondary Accessions:
    • B9EG97
    • O43668
    • Q8WYJ8

    Protein attributes for ZFX Gene

    805 amino acids
    Molecular mass:
    90522 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZFX Gene


neXtProt entry for ZFX Gene

Post-translational modifications for ZFX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ZFX (ZFX)

No data available for DME Specific Peptides for ZFX Gene

Domains & Families for ZFX Gene

Gene Families for ZFX Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
  • Contains 13 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFX: view

Function for ZFX Gene

Molecular function for ZFX Gene

GENATLAS Biochemistry:
zinc finger protein,X-linked,putative transcription activator with alternative isoforms,575 and 804 AA,escaping inactivation
UniProtKB/Swiss-Prot Function:
Probable transcriptional activator.

Gene Ontology (GO) - Molecular Function for ZFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003677 DNA binding TAS 2500252
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0003713 transcription coactivator activity TAS 2105457
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFX: view
genes like me logo Genes that share phenotypes with ZFX: view

Human Phenotype Ontology for ZFX Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ZFX Gene

MGI Knock Outs for ZFX:

Animal Model Products

CRISPR Products

miRNA for ZFX Gene

miRTarBase miRNAs that target ZFX
Targeted motifs for ZFX Gene
HOMER Transcription Factor Regulatory Elements motif ZFX
  • Consensus sequence: AGGCCTGG Submotif: canonical Cell Type: mES GEO ID: GSE11431

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for ZFX Gene

Localization for ZFX Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFX Gene


Subcellular locations from

Jensen Localization Image for ZFX Gene COMPARTMENTS Subcellular localization image for ZFX gene
Compartment Confidence
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFX: view

Pathways & Interactions for ZFX Gene

SuperPathways for ZFX Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with ZFX: view

No data available for Pathways by source and SIGNOR curated interactions for ZFX Gene

Drugs & Compounds for ZFX Gene

(2) Drugs for ZFX Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZFX: view

Transcripts for ZFX Gene

Unigene Clusters for ZFX Gene

Zinc finger protein, X-linked:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFX Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - - - - -

Relevant External Links for ZFX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFX Gene

mRNA expression in normal human tissues for ZFX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFX Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.8), Rectum (16.7), and Ovary (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFX Gene

Protein tissue co-expression partners for ZFX Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFX Gene:


SOURCE GeneReport for Unigene cluster for ZFX Gene:

genes like me logo Genes that share expression patterns with ZFX: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFX Gene

Orthologs for ZFX Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFX Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZFX 34
  • 94.12 (n)
  • 96.87 (a)
ZFX 35
  • 98 (a)
(Canis familiaris)
Mammalia ZFX 34
  • 95.41 (n)
  • 98.5 (a)
ZFX 35
  • 98 (a)
(Mus musculus)
Mammalia Zfx 34
  • 91.81 (n)
  • 95.61 (a)
Zfx 16
Zfx 35
  • 96 (a)
(Pan troglodytes)
Mammalia ZFX 34
  • 99.58 (n)
  • 99.63 (a)
ZFX 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfx 34
  • 90.59 (n)
  • 91.34 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 87 (a)
(Gallus gallus)
Aves ZFX 34
  • 84.39 (n)
  • 90.78 (a)
-- 35
  • 91 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4675 34
zfx 34
  • 73.52 (n)
  • 77.49 (a)
African clawed frog
(Xenopus laevis)
Amphibia XZFY-1 34
(Danio rerio)
Actinopterygii zfx 34
  • 64.03 (n)
  • 64.36 (a)
CABZ01079241.1 35
  • 64 (a)
zfx 35
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1741 34
Species where no ortholog for ZFX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFX Gene

Gene Tree for ZFX (if available)
Gene Tree for ZFX (if available)

Paralogs for ZFX Gene

Paralogs for ZFX Gene

genes like me logo Genes that share paralogs with ZFX: view

Variants for ZFX Gene

Sequence variations from dbSNP and Humsavar for ZFX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747672081 -- 24,180,670(+) GAGGT(A/G)TCACG intron-variant
rs747696518 -- 24,177,691(+) TCAGA(A/G)GATGA intron-variant, upstream-variant-2KB
rs747715657 -- 24,215,260(+) TGGGA(-/ATC)ATCTC utr-variant-3-prime
rs747735463 -- 24,196,404(+) CACTG(C/T)GCCCA intron-variant
rs747740789 -- 24,156,057(+) ATGCC(C/T)GGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFX Gene

Variant ID Type Subtype PubMed ID
dgv504n21 CNV gain 19592680
esv2674864 CNV deletion 23128226
nsv1076250 CNV deletion 25765185
nsv1122261 CNV deletion 24896259
nsv1145288 CNV deletion 24896259
nsv515191 CNV gain 21397061
nsv515192 CNV gain 21397061
nsv524256 CNV gain 19592680
nsv818019 CNV gain 17921354

Variation tolerance for ZFX Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFX Gene

Disorders for ZFX Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZFX Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gallbladder cancer
  • gallbladder ca
x-linked disease
- elite association - COSMIC cancer census association via MalaCards
Search ZFX in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZFX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZFX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFX Gene

Publications for ZFX Gene

  1. Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY. (PMID: 2041734) North M. … Ferguson-Smith M.A. (Nucleic Acids Res. 1991) 3 4 22 65
  2. Cloning and comparative analysis of the bovine, porcine, and equine sex chromosome genes ZFX and ZFY. (PMID: 15060604) Poloumienko A. (Genome 2004) 3 22 65
  3. Paternal transcripts for glucose-6-phosphate dehydrogenase and adenosine deaminase are first detectable in the human preimplantation embryo at the three- to four-cell stage. (PMID: 9364438) Taylor D.M. … Handyside A.H. (Mol. Reprod. Dev. 1997) 3 22 65
  4. Comparison of human ZFY and ZFX transcripts. (PMID: 2308929) Palmer M.S. … Goodfellow P.N. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4 65
  5. ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation. (PMID: 2500252) Schneider-Gaedicke A. … Page D.C. (Cell 1989) 3 4 65

Products for ZFX Gene

Sources for ZFX Gene

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