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Aliases for ZFX Gene

Aliases for ZFX Gene

  • Zinc Finger Protein, X-Linked 2 3
  • Zinc Finger X-Chromosomal Protein 3
  • X-Linked Zinc Finger Protein 3
  • ZNF926 3

External Ids for ZFX Gene

Previous GeneCards Identifiers for ZFX Gene

  • GC0XP022985
  • GC0XP022816
  • GC0XP023369
  • GC0XP023531
  • GC0XP023529
  • GC0XP023927
  • GC0XP024077
  • GC0XP021912

Summaries for ZFX Gene

Entrez Gene Summary for ZFX Gene

  • This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]

GeneCards Summary for ZFX Gene

ZFX (Zinc Finger Protein, X-Linked) is a Protein Coding gene. Diseases associated with ZFX include x-linked disease and retinoschisis. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is ZFY.

UniProtKB/Swiss-Prot for ZFX Gene

  • Probable transcriptional activator

Gene Wiki entry for ZFX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFX Gene

Genomics for ZFX Gene

Regulatory Elements for ZFX Gene

Genomic Location for ZFX Gene

24,148,934 bp from pter
24,216,255 bp from pter
67,322 bases
Plus strand

Genomic View for ZFX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFX Gene

Proteins for ZFX Gene

  • Protein details for ZFX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger X-chromosomal protein
    Protein Accession:
    Secondary Accessions:
    • B9EG97
    • O43668
    • Q8WYJ8

    Protein attributes for ZFX Gene

    805 amino acids
    Molecular mass:
    90522 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZFX Gene


neXtProt entry for ZFX Gene

Proteomics data for ZFX Gene at MOPED

Post-translational modifications for ZFX Gene

  • Ubiquitination at Lys715
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ZFX (ZFX)

No data available for DME Specific Peptides for ZFX Gene

Domains for ZFX Gene

Gene Families for ZFX Gene

  • ZNF :Zinc fingers, C2H2-type

Graphical View of Domain Structure for InterPro Entry



  • P17010
  • Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFX: view

Function for ZFX Gene

Molecular function for ZFX Gene

GENATLAS Biochemistry:
zinc finger protein,X-linked,putative transcription activator with alternative isoforms,575 and 804 AA,escaping inactivation
UniProtKB/Swiss-Prot Function:
Probable transcriptional activator

Gene Ontology (GO) - Molecular Function for ZFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity TAS 2105457
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFX: view
genes like me logo Genes that share phenotypes with ZFX: view

Animal Models for ZFX Gene

MGI Knock Outs for ZFX:

Animal Model Products

miRNA for ZFX Gene

miRTarBase miRNAs that target ZFX
Targeting motifs for ZFX Gene
HOMER Transcription Factor Regulatory Elements motif ZFX
  • Consensus sequence: AGGCCTGG Submotif: canonical Cell Type: mES GeoId: GSE11431

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFX

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for ZFX Gene

Localization for ZFX Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFX Gene


Subcellular locations from

Jensen Localization Image for ZFX Gene COMPARTMENTS Subcellular localization image for ZFX gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFX: view

Pathways for ZFX Gene

SuperPathways for ZFX Gene

No Data Available

Interacting Proteins for ZFX Gene

Gene Ontology (GO) - Biological Process for ZFX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZFX: view

No data available for Pathways by source for ZFX Gene

Compounds for ZFX Gene

(2) Novoseek inferred chemical compound relationships for ZFX Gene

Compound -log(P) Hits PubMed IDs
zinc 61.3 10
glucose 6-phosphate 37.9 1
genes like me logo Genes that share compounds with ZFX: view

Transcripts for ZFX Gene

Unigene Clusters for ZFX Gene

Zinc finger protein, X-linked:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFX

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFX Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - - - - -

Relevant External Links for ZFX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFX Gene

mRNA expression in normal human tissues for ZFX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ZFX Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.8), Rectum (16.7), and Ovary (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFX Gene

SOURCE GeneReport for Unigene cluster for ZFX Gene Hs.336681

genes like me logo Genes that share expressions with ZFX: view

Expression partners for ZFX Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFX Gene

Orthologs for ZFX Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFX Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZFX 35
  • 94.12 (n)
  • 96.87 (a)
ZFX 36
  • 98 (a)
(Canis familiaris)
Mammalia ZFX 35
  • 95.41 (n)
  • 98.5 (a)
ZFX 36
  • 98 (a)
(Mus musculus)
Mammalia Zfx 35
  • 91.81 (n)
  • 95.61 (a)
Zfx 16
Zfx 36
  • 96 (a)
(Pan troglodytes)
Mammalia ZFX 35
  • 99.58 (n)
  • 99.63 (a)
ZFX 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfx 35
  • 90.59 (n)
  • 91.34 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
(Gallus gallus)
Aves ZFX 35
  • 84.39 (n)
  • 90.78 (a)
-- 36
  • 91 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4675 35
zfx 35
  • 73.52 (n)
  • 77.49 (a)
African clawed frog
(Xenopus laevis)
Amphibia XZFY-1 35
(Danio rerio)
Actinopterygii zfx 35
  • 64.03 (n)
  • 64.36 (a)
CABZ01079241.1 36
  • 64 (a)
zfx 36
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1741 35
Species with no ortholog for ZFX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFX Gene

Gene Tree for ZFX (if available)
Gene Tree for ZFX (if available)

Paralogs for ZFX Gene

Paralogs for ZFX Gene

genes like me logo Genes that share paralogs with ZFX: view

Variants for ZFX Gene

Sequence variations from dbSNP and Humsavar for ZFX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs13679 -- 24,215,792(+) AAGGT(A/T)AACTG utr-variant-3-prime
rs739503 -- 24,153,032(+) GCTCA(C/T)GAATG intron-variant
rs1042604 -- 24,213,978(+) TACTC(C/T)GGAAT utr-variant-3-prime
rs1062608 -- 24,208,289(+) GCAGG(A/G)CAGCC missense, reference
rs1126787 -- 24,207,339(+) GCTGG(A/C)AAAAT synonymous-codon, reference, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZFX Gene

Variant ID Type Subtype PubMed ID
nsv524256 CNV Gain 19592680
nsv818019 CNV Gain 17921354
dgv504n21 CNV Gain 19592680
esv2674864 CNV Deletion 23128226
nsv515191 CNV Gain 21397061
nsv515192 CNV Gain 21397061

Relevant External Links for ZFX Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFX Gene

Disorders for ZFX Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ZFX Gene in MalaCards »

(2) Diseases for ZFX Gene including...

(1) University of Copenhagen DISEASES for ZFX Gene

genes like me logo Genes that share disorders with ZFX: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for ZFX Gene

Publications for ZFX Gene

  1. Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY. (PMID: 2041734) North M. … Ferguson-Smith M.A. (Nucleic Acids Res. 1991) 3 4 23
  2. Paternal transcripts for glucose-6-phosphate dehydrogenase and adenosine deaminase are first detectable in the human preimplantation embryo at the three- to four-cell stage. (PMID: 9364438) Taylor D.M. … Handyside A.H. (Mol. Reprod. Dev. 1997) 3 23
  3. Cloning and comparative analysis of the bovine, porcine, and equine sex chromosome genes ZFX and ZFY. (PMID: 15060604) Poloumienko A. (Genome 2004) 3 23
  4. ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation. (PMID: 2500252) Schneider-Gaedicke A. … Page D.C. (Cell 1989) 3 4
  5. Putative transcription activator with alternative isoforms encoded by human ZFX gene. (PMID: 2512506) Schneider-Gaedicke A. … Page D.C. (Nature 1989) 3 4

Products for ZFX Gene

Sources for ZFX Gene

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