ZFX Gene
protein-coding GIFtS: 51
GCID: GC0XP024167
|
|
zinc finger protein, X-linked
| |
Aliases
for ZFX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein, X-Linked1 2 | | ZNF9261 2 | | X-Linked Zinc Finger Protein2 | | Zinc Finger X-Chromosomal Protein2 |
Export aliases for ZFX gene to outside databasesPrevious GC identifers: GC0XP022985 GC0XP022816 GC0XP023369 GC0XP023531 GC0XP023529 GC0XP023927 GC0XP024077 GC0XP021912 |
Summaries
for ZFX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZFX:
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of thekrueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activationdomain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zincfingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as atranscriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth anddifferentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms havebeen identified, but the full-length nature of some variants has not been determined. (provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: ZFX_HUMAN, P17010Function: Probable transcriptional activator
Gene Wiki entry for ZFX
|
Genomic Views
for ZFX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZFX gene promoter:
AhR Spz1 POU3F1 FOXD3 Pax-4a Gfi-1 Arnt YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZFX
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFX |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp21.3 Ensembl cytogenetic band: Xp22.11 HGNC cytogenetic band: Xp22.1-p21.3ZFX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP024167: view genomic region
(about GC identifiers)
Start:
|
24,167,290 bp from pter |
End:
|
24,234,372 bp from pter |
Size:
|
67,083 bases |
Orientation:
|
plus strand |
|
Proteins
for ZFX gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZFX_HUMAN, P17010 (See
protein sequence)Recommended Name: Zinc finger X-chromosomal protein Size: 805 amino acids; 90522 Da
Subcellular location: Nucleus
Secondary accessions: O43668 Q8WYJ8Alternative splicing: 2 isoforms: P17010-1 P17010-2 Explore the universe of human proteins at neXtProt for ZFX: NX_P17010
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17010
ZFX Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001171555.1 NP_001171556.1 NP_001171557.1 NP_001171566.1 NP_003401.2
ENSEMBL proteins: ENSP00000411637 ENSP00000416298 ENSP00000368475 ENSP00000304985 ENSP00000343384 ENSP00000368486 ENSP00000441382 ENSP00000438233
Human Recombinant Protein Products for ZFX:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZFX for ontologies About GeneDecksing
ZFX Antibody Products:
Assay Products for ZFX: |
Protein
Domains /
Families
for ZFX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZFX for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P17010ProtoNet protein and cluster: P17010 2 Blocks protein families: IPB006794 Zfx / Zfy transcription activation region IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZFX_HUMAN, P17010Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamilySimilarity: Contains 13 C2H2-type zinc fingers |
Function
for ZFX gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZFX_HUMAN, P17010Function: Probable transcriptional activator Genatlas biochemistry entry for ZFX:zinc finger protein,X-linked,putative transcription activator with alternative isoforms,575 and 804 AA,escapinginactivation
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZFX for ontologies About GeneDecksing
Phenotypes:
4 GenomeRNAi human phenotypes for ZFX:
8 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Zfx):
ZFX for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for ZFX: Zfxtm1.2Reiz Zfxtm1Dcp
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFX (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFX (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZFX | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFX |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFX |
|
Pathways & Interactions
for ZFX gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFX
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZFX for ontologies About GeneDecksing
|
Drugs & Compounds
for ZFX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ZFX for compounds About GeneDecksing
 Browse Tocris compounds for ZFX
2 Novoseek chemical compound relationships for ZFX gene About this table
Search CenterWatch for drugs/clinical trials and news about ZFX
|
Transcripts
for ZFX gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZFX gene (5 alternative transcripts): NM_001178084.1 NM_001178085.1 NM_001178086.1 NM_001178095.1 NM_003410.3 Unigene Cluster for ZFX: Zinc finger protein, X-linked Hs.336681 [show with all ESTs]Unigene Representative Sequence: NM_00117808512 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000497813 ENST00000428571 ENST00000419690 ENST00000379177(uc004dbd.2 uc004dbf.3 uc011mjv.2)
ENST00000304543 ENST00000459724 ENST00000480195 ENST00000338565(uc010nfy.1)
ENST00000474385 ENST00000379188(uc004dbe.3 uc022bua.1) ENST00000540034
ENST00000539115(uc010nfx.2 uc010nfz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFX (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFX (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Additional cDNA sequence: AB209892.1 AF454950.1 AF505615.1 AF505616.1 AF505617.1 AF505618.1 AF505619.1 AY072770.1 BC030756.2 BC136308.1 BC136309.1 M30608.1 X59738.1 X59739.1 X59740.1 11 DOTS entries: DT.92424037 DT.121299582 DT.91754275 DT.101976110 DT.121299573 DT.95266567 DT.95095924 DT.95264329 DT.100751052 DT.100751054 DT.313255 24/144 AceView cDNA sequences (see all 144): M30608 BM699597 AF505618 BX281676 AA343391 CD722604 AA983930 AI695183 NM_003410 BQ022250 AU185591 BX498885 BM825561 AL691932 BX113165 CB112763 BM747640 AV760444 BU075677 BV203070 CA950979 BG615698 BM475678 AL042462
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ZFX (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9 |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZFX
|
Expression
for ZFX gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZFX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTTTTCCTA
About this image
See ZFX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZFX
SOURCE GeneReport for Unigene cluster: Hs.336681
SABiosciences Custom PCR Arrays for ZFX
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFX
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFX | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFX |
Orthologs
for ZFX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZFX gene from 4/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZFX1 |
zinc finger protein, X-linked |
84.55(n)
91.16(a) |
|
418596 XM_416795.3 XP_416795.2 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
82(a) |
1 → many |
3(125817758-125832276) |
African clawed frog
(Xenopus laevis) |
Amphibia |
XZFY-12 |
X.laevis XZFY-1 mRNA |
77.37(n) |
|
X68024.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zfx1 |
zinc finger protein, X-linked |
63.93(n)
63.08(a) |
|
560346 XM_683750.5 XP_688842.3 |
ENSEMBL Gene Tree for ZFX (if available)
TreeFam Gene Tree for ZFX (if available) |
Paralogs
for ZFX gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZFX gene
- ZNF6392 ZFY2 ZNF7112
18/292 SIMAP similar genes for ZFX using alignment to 17 protein entries: ZFX_HUMAN (see all proteins)
(see all similar genes):ZFY CNOT2 ZNF654 ZNF711 ZNF536 ZNF55
ZNF72 HZF16 PRDM15 ZNF298 ZNF516 ZNF891
ZFS-2 ZNF ZNF550 IKZF4 ZFAT ZNF217
ZFX for paralogs About GeneDecksing
|
Genomic Variants
for ZFX gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZFX (24167290 - 24234372 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ZFX
3 CNVs: 52976 52975 9338
Locus Specific Mutation Databases (LSDB): ZFX
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ZFX gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZFX for disorders About GeneDecksing
OMIM gene information: 314980
OMIM disorders: --
8  diseases for ZFX: About MalaCardsx-linked disease premature ovarian failure x inactivation retinoschisis
azoospermia prostate adenocarcinoma adenocarcinoma prostatitis
2 diseases from the University of Copenhagen DISEASES database for ZFX:Azoospermia Retinoschisis Export disorders for ZFX gene to outside databases
|
Publications
for ZFX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZFX gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with ZFX) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY. (PubMed id 2041734)1, 2, 9 North M....Ferguson-Smith M.A. (1991)
- Comparison of human ZFY and ZFX transcripts. (PubMed id 2308929)1, 2 Palmer M.S.... Goodfellow P.N. (1990)
- Putative transcription activator with alternative isoforms encoded by human ZFX gene. (PubMed id 2512506)1, 2 Schneider-Gaedicke A.... Page D.C. (1989)
- ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation. (PubMed id 2500252)1, 2 Schneider-Gaedicke A....Page D.C. (1989)
- Cloning and comparative analysis of the bovine, porcine, and equine sex chromosome genes ZFX and ZFY. (PubMed id 15060604)1, 9 Poloumienko A. (2004)
- Paternal transcripts for glucose-6-phosphate dehydrogenase and adenosine deaminase are first detectable in the human preimplantation embryo at the three- to four-cell stage. (PubMed id 9364438)1, 9 Taylor D.M....Handyside A.H. (1997)
- Knockdown of zinc finger protein, X-linked (ZFX) inhib its cell proliferation and induces apoptosis in human laryngeal squamous cell ca rcinoma. (PubMed id 22009483)1 Fang J....Han D. (2012)
- Differential expression of ZFX gene in gastric cancer. (PubMed id 22357206)1 Nikpour P....Haghjooy-Javanmard S. (2012)
- Clinical significance of miR-144-ZFX axis in dissemina ted tumour cells in bone marrow in gastric cancer cases. (PubMed id 22955854)1 Akiyoshi S....Mori M. (2012)
- ZFX controls the self-renewal of human embryonic stem cells. (PubMed id 22879936)1 Harel S....Tomishima M.J. (2012)
|
External Searches for ZFX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZFX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZFX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZFX gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZFX | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZFX gene:
Search GeneIP for patents involving ZFX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZFX gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFX |
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