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Aliases for ZFR2 Gene

Aliases for ZFR2 Gene

  • Zinc Finger RNA Binding Protein 2 2 3
  • KIAA1086 2 3 4
  • Zinc Finger RNA-Binding Protein 2 3

External Ids for ZFR2 Gene

Previous HGNC Symbols for ZFR2 Gene

  • KIAA1086

Previous GeneCards Identifiers for ZFR2 Gene

  • GC19M003756
  • GC19M003568

Summaries for ZFR2 Gene

GeneCards Summary for ZFR2 Gene

ZFR2 (Zinc Finger RNA Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFR.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFR2 Gene

Genomics for ZFR2 Gene

Regulatory Elements for ZFR2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZFR2 Gene

Start:
3,804,024 bp from pter
End:
3,869,032 bp from pter
Size:
65,009 bases
Orientation:
Minus strand

Genomic View for ZFR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFR2 Gene

Proteins for ZFR2 Gene

  • Protein details for ZFR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPR6-ZFR2_HUMAN
    Recommended name:
    Zinc finger RNA-binding protein 2
    Protein Accession:
    Q9UPR6
    Secondary Accessions:
    • B4DHD0

    Protein attributes for ZFR2 Gene

    Size:
    939 amino acids
    Molecular mass:
    101330 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZFR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFR2 Gene

Proteomics data for ZFR2 Gene at MOPED

Post-translational modifications for ZFR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFR2 Gene

Domains for ZFR2 Gene

Protein Domains for ZFR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPR6

UniProtKB/Swiss-Prot:

ZFR2_HUMAN :
  • Q9UPR6
Domain:
  • Contains 1 DZF domain.
genes like me logo Genes that share domains with ZFR2: view

No data available for Gene Families for ZFR2 Gene

Function for ZFR2 Gene

Gene Ontology (GO) - Molecular Function for ZFR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZFR2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZFR2 Gene

Localization for ZFR2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFR2 Gene COMPARTMENTS Subcellular localization image for ZFR2 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZFR2 Gene

Pathways for ZFR2 Gene

SuperPathways for ZFR2 Gene

No Data Available

Interacting Proteins for ZFR2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000262961%0d%0a9606.ENSP00000355011%0d%0a9606.ENSP00000355094%0d%0a9606.ENSP00000281156%0d%0a9606.ENSP00000366604%0d%0a
Selected Interacting proteins: ENSP00000262961 Q9UPR6-ZFR2_HUMAN for ZFR2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ZFR2 Gene

None

No data available for Pathways by source for ZFR2 Gene

Transcripts for ZFR2 Gene

mRNA/cDNA for ZFR2 Gene

Unigene Clusters for ZFR2 Gene

Zinc finger RNA binding protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFR2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZFR2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFR2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: - -
SP3: -
SP4:

Relevant External Links for ZFR2 Gene

GeneLoc Exon Structure for
ZFR2
ECgene alternative splicing isoforms for
ZFR2

Expression for ZFR2 Gene

mRNA expression in normal human tissues for ZFR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZFR2 Gene

This gene is overexpressed in Pituitary (9.2), Brain - Cortex (5.6), Brain - Hypothalamus (4.6), Brain - Frontal Cortex (BA9) (4.5), Testis (4.1), Brain - Anterior cingulate cortex (BA24) (4.1), and Brain - Nucleus accumbens (basal ganglia) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZFR2 Gene

SOURCE GeneReport for Unigene cluster for ZFR2 Gene Hs.65750

genes like me logo Genes that share expressions with ZFR2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ZFR2 Gene

Orthologs for ZFR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFR2 35
  • 97.83 (n)
  • 97.02 (a)
ZFR2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFR2 35
  • 74.48 (n)
  • 67.67 (a)
ZFR2 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFR2 35
  • 73.68 (n)
  • 63.45 (a)
ZFR2 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfr2 35
  • 69.25 (n)
  • 60.28 (a)
Zfr2 16
Zfr2 36
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFR2 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Zfr2 35
  • 71.55 (n)
  • 63.98 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 4 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zfr2 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Zn72D 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y95B8A.8 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9218 36
  • 21 (a)
OneToMany
Species with no ortholog for ZFR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZFR2 Gene

ENSEMBL:
Gene Tree for ZFR2 (if available)
TreeFam:
Gene Tree for ZFR2 (if available)

Paralogs for ZFR2 Gene

Paralogs for ZFR2 Gene

Selected SIMAP similar genes for ZFR2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZFR2: view

Variants for ZFR2 Gene

Sequence variations from dbSNP and Humsavar for ZFR2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3346 -- 3,851,914(+) GTGAC(A/G)GACAT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs739933 -- 3,824,215(-) TCAAG(C/T)GATCC intron-variant
rs739934 -- 3,835,052(+) TGACG(C/G)TGTCA intron-variant
rs739935 -- 3,835,260(+) ACTTC(C/T)GCTTT intron-variant
rs757436 -- 3,826,751(+) ACCTT(A/T)CTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFR2 Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
nsv509718 CNV Insertion 20534489
nsv910770 CNV Loss 21882294
nsv910777 CNV Loss 21882294
nsv833715 CNV Loss 17160897
dgv3664n71 CNV Loss 21882294
nsv910780 CNV Loss 21882294
esv2717969 CNV Deletion 23290073
esv2717970 CNV Deletion 23290073
esv2071608 CNV Deletion 18987734
esv2743112 CNV Deletion 23290073
esv5059 CNV Deletion 18987735
esv2717971 CNV Deletion 23290073
esv2717972 CNV Deletion 23290073
esv2666653 CNV Deletion 23128226
esv2717974 CNV Deletion 23290073
esv1995150 CNV Deletion 18987734
nsv138020 CNV Loss 16902084
esv991288 CNV Deletion 20482838
esv2717975 CNV Deletion 23290073
esv1602911 CNV Deletion 17803354

Relevant External Links for ZFR2 Gene

HapMap Linkage Disequilibrium report
ZFR2
Human Gene Mutation Database (HGMD)
ZFR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFR2 Gene

Disorders for ZFR2 Gene

Relevant External Links for ZFR2

Genetic Association Database (GAD)
ZFR2
genes like me logo Genes that share disorders with ZFR2: view

No data available for UniProtKB/Swiss-Prot for ZFR2 Gene

Publications for ZFR2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4

Products for ZFR2 Gene

Sources for ZFR2 Gene

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