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Aliases for ZFR2 Gene

Aliases for ZFR2 Gene

  • Zinc Finger RNA Binding Protein 2 2 3 5
  • KIAA1086 2 3 4
  • Zinc Finger RNA-Binding Protein 2 3

External Ids for ZFR2 Gene

Previous HGNC Symbols for ZFR2 Gene

  • KIAA1086

Previous GeneCards Identifiers for ZFR2 Gene

  • GC19M003756
  • GC19M003568

Summaries for ZFR2 Gene

GeneCards Summary for ZFR2 Gene

ZFR2 (Zinc Finger RNA Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFR.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFR2 Gene

Genomics for ZFR2 Gene

Regulatory Elements for ZFR2 Gene

Enhancers for ZFR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G003821 1.2 Ensembl ENCODE 17.2 +46.6 46560 1.4 ATF1 ARNT AGO1 FEZF1 ZNF2 ZNF143 ZNF207 KLF13 KDM4B SP3 ZFR2 GC19P003816 GC19P003837
GH19G003828 1 Ensembl ENCODE 19.3 +40.4 40419 0.6 ATF1 ETV1 JUN UBTF FOSL1 EGR1 RCOR1 CREM TCF7L2 SMARCE1 ZFR2 ATCAY RAX2 MRPL54 APBA3 GC19P003837 GC19P003816
GH19G003818 0.7 Ensembl ENCODE 17.4 +50.1 50141 1.0 ZNF335 RFX1 ZFR2 GC19P003816 GC19P003837
GH19G003725 1 ENCODE dbSUPER 11.6 +143.0 143018 1.5 BCOR PKNOX1 TEAD4 ZMYM3 ZIC2 ZNF121 PRDM10 ZNF263 MAZ SP2 MRPL54 APBA3 RAX2 ZFR2 GC19P003720 GC19P003750
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZFR2 Gene

3,804,024 bp from pter
3,869,032 bp from pter
65,009 bases
Minus strand

Genomic View for ZFR2 Gene

Genes around ZFR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFR2 Gene

Proteins for ZFR2 Gene

  • Protein details for ZFR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger RNA-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DHD0

    Protein attributes for ZFR2 Gene

    939 amino acids
    Molecular mass:
    101330 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZFR2 Gene


neXtProt entry for ZFR2 Gene

Post-translational modifications for ZFR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFR2 Gene

Domains & Families for ZFR2 Gene

Protein Domains for ZFR2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZFR2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ZFR2 Gene

Function for ZFR2 Gene

Gene Ontology (GO) - Molecular Function for ZFR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFR2: view

Phenotypes for ZFR2 Gene

genes like me logo Genes that share phenotypes with ZFR2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFR2 Gene

Localization for ZFR2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFR2 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZFR2 Gene

Pathways & Interactions for ZFR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFR2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZFR2 Gene

Drugs & Compounds for ZFR2 Gene

No Compound Related Data Available

Transcripts for ZFR2 Gene

mRNA/cDNA for ZFR2 Gene

Unigene Clusters for ZFR2 Gene

Zinc finger RNA binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFR2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP2: - -
SP3: -

Relevant External Links for ZFR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZFR2 Gene

This gene is overexpressed in Pituitary (x9.2), Brain - Cortex (x5.6), Brain - Hypothalamus (x4.6), Brain - Frontal Cortex (BA9) (x4.5), Testis (x4.1), Brain - Anterior cingulate cortex (BA24) (x4.1), and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for ZFR2 Gene

This gene is overexpressed in Adipocyte (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZFR2 Gene

Protein tissue co-expression partners for ZFR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFR2 Gene:


SOURCE GeneReport for Unigene cluster for ZFR2 Gene:


Evidence on tissue expression from TISSUES for ZFR2 Gene

  • Nervous system(4.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with ZFR2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFR2 Gene

Orthologs for ZFR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFR2 34 35
  • 97.83 (n)
(Bos Taurus)
Mammalia ZFR2 34 35
  • 74.48 (n)
(Canis familiaris)
Mammalia ZFR2 34 35
  • 73.68 (n)
(Rattus norvegicus)
Mammalia Zfr2 34
  • 71.55 (n)
(Mus musculus)
Mammalia Zfr2 34 16 35
  • 69.25 (n)
(Monodelphis domestica)
Mammalia ZFR2 35
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 45 (a)
(Gallus gallus)
Aves -- 35
  • 4 (a)
(Danio rerio)
Actinopterygii zfr2 35
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Zn72D 35
  • 40 (a)
(Caenorhabditis elegans)
Secernentea Y95B8A.8 35
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9218 35
  • 21 (a)
Species where no ortholog for ZFR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZFR2 Gene

Gene Tree for ZFR2 (if available)
Gene Tree for ZFR2 (if available)

Paralogs for ZFR2 Gene

Paralogs for ZFR2 Gene

(3) SIMAP similar genes for ZFR2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZFR2: view

Variants for ZFR2 Gene

Sequence variations from dbSNP and Humsavar for ZFR2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000021375 -- 3,853,847(+) GAGGA(C/T)AGCTT intron-variant
rs1000135816 -- 3,838,088(+) TGACA(C/T)GCGAT intron-variant
rs1000170926 -- 3,819,432(+) GCTGC(A/C)GGAAG intron-variant
rs1000280143 -- 3,814,687(+) GGGCT(A/G)TATCT intron-variant
rs1000341076 -- 3,846,548(+) TCTGC(C/T)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFR2 Gene

Variant ID Type Subtype PubMed ID
dgv1693n106 CNV deletion 24896259
dgv6227n54 CNV gain 21841781
esv1602911 CNV deletion 17803354
esv1995150 CNV deletion 18987734
esv2071608 CNV deletion 18987734
esv2666653 CNV deletion 23128226
esv2717969 CNV deletion 23290073
esv2717970 CNV deletion 23290073
esv2717971 CNV deletion 23290073
esv2717972 CNV deletion 23290073
esv2717974 CNV deletion 23290073
esv2717975 CNV deletion 23290073
esv2743112 CNV deletion 23290073
esv3325589 CNV duplication 20981092
esv3383353 CNV duplication 20981092
esv3555889 CNV deletion 23714750
esv3643473 CNV gain 21293372
esv3643475 CNV loss 21293372
esv3643476 CNV gain 21293372
esv3643477 CNV loss 21293372
esv3643478 CNV loss 21293372
esv5059 CNV loss 18987735
esv991288 CNV deletion 20482838
nsv1072843 CNV deletion 25765185
nsv1123210 CNV deletion 24896259
nsv1138657 CNV deletion 24896259
nsv1150390 CNV deletion 26484159
nsv138020 CNV deletion 16902084
nsv470114 CNV loss 18288195
nsv509718 CNV insertion 20534489
nsv833715 CNV loss 17160897

Variation tolerance for ZFR2 Gene

Gene Damage Index Score: 11.33; 92.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFR2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFR2 Gene

Disorders for ZFR2 Gene

Relevant External Links for ZFR2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZFR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFR2 Gene

Publications for ZFR2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for ZFR2 Gene

Sources for ZFR2 Gene

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