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Aliases for ZFR2 Gene

Aliases for ZFR2 Gene

  • Zinc Finger RNA Binding Protein 2 2 3 5
  • KIAA1086 2 3 4

External Ids for ZFR2 Gene

Previous HGNC Symbols for ZFR2 Gene

  • KIAA1086

Previous GeneCards Identifiers for ZFR2 Gene

  • GC19M003756
  • GC19M003568

Summaries for ZFR2 Gene

GeneCards Summary for ZFR2 Gene

ZFR2 (Zinc Finger RNA Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFR.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFR2 Gene

Genomics for ZFR2 Gene

Regulatory Elements for ZFR2 Gene

Enhancers for ZFR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZFR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZFR2 Gene

3,804,024 bp from pter
3,869,032 bp from pter
65,009 bases
Minus strand

Genomic View for ZFR2 Gene

Genes around ZFR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFR2 Gene

Proteins for ZFR2 Gene

  • Protein details for ZFR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger RNA-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DHD0

    Protein attributes for ZFR2 Gene

    939 amino acids
    Molecular mass:
    101330 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZFR2 Gene


neXtProt entry for ZFR2 Gene

Proteomics data for ZFR2 Gene at MOPED

Post-translational modifications for ZFR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFR2 Gene

Domains & Families for ZFR2 Gene

Protein Domains for ZFR2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DZF domain.
  • Contains 1 DZF domain.
genes like me logo Genes that share domains with ZFR2: view

No data available for Gene Families for ZFR2 Gene

Function for ZFR2 Gene

Gene Ontology (GO) - Molecular Function for ZFR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZFR2: view

Phenotypes for ZFR2 Gene

genes like me logo Genes that share phenotypes with ZFR2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFR2 Gene

Localization for ZFR2 Gene

Subcellular locations from

Jensen Localization Image for ZFR2 Gene COMPARTMENTS Subcellular localization image for ZFR2 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZFR2 Gene

Pathways & Interactions for ZFR2 Gene

SuperPathways for ZFR2 Gene

No Data Available

Interacting Proteins for ZFR2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000262961 Q9UPR6-ZFR2_HUMAN for ZFR2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ZFR2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZFR2 Gene

Drugs & Compounds for ZFR2 Gene

No Compound Related Data Available

Transcripts for ZFR2 Gene

mRNA/cDNA for ZFR2 Gene

Unigene Clusters for ZFR2 Gene

Zinc finger RNA binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFR2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP2: - -
SP3: -

Relevant External Links for ZFR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFR2 Gene

mRNA expression in normal human tissues for ZFR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZFR2 Gene

This gene is overexpressed in Pituitary (x9.2), Brain - Cortex (x5.6), Brain - Hypothalamus (x4.6), Brain - Frontal Cortex (BA9) (x4.5), Testis (x4.1), Brain - Anterior cingulate cortex (BA24) (x4.1), and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for ZFR2 Gene

This gene is overexpressed in Adipocyte (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZFR2 Gene

SOURCE GeneReport for Unigene cluster for ZFR2 Gene Hs.65750

genes like me logo Genes that share expression patterns with ZFR2: view

Protein tissue co-expression partners for ZFR2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZFR2 Gene

Orthologs for ZFR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZFR2 35
  • 74.48 (n)
  • 67.67 (a)
ZFR2 36
  • 61 (a)
(Canis familiaris)
Mammalia ZFR2 35
  • 73.68 (n)
  • 63.45 (a)
ZFR2 36
  • 60 (a)
(Mus musculus)
Mammalia Zfr2 35
  • 69.25 (n)
  • 60.28 (a)
Zfr2 16
Zfr2 36
  • 54 (a)
(Pan troglodytes)
Mammalia ZFR2 35
  • 97.83 (n)
  • 97.02 (a)
ZFR2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Zfr2 35
  • 71.55 (n)
  • 63.98 (a)
(Monodelphis domestica)
Mammalia ZFR2 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
(Gallus gallus)
Aves -- 36
  • 4 (a)
(Danio rerio)
Actinopterygii zfr2 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Zn72D 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea Y95B8A.8 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9218 36
  • 21 (a)
Species with no ortholog for ZFR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZFR2 Gene

Gene Tree for ZFR2 (if available)
Gene Tree for ZFR2 (if available)

Paralogs for ZFR2 Gene

Paralogs for ZFR2 Gene

(3) SIMAP similar genes for ZFR2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZFR2: view

Variants for ZFR2 Gene

Sequence variations from dbSNP and Humsavar for ZFR2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2240235 - 3,831,767(+) ATCCC(A/G)AGGAC nc-transcript-variant, reference, missense
rs2240234 - 3,831,711(+) GGTCA(C/T)GATGG nc-transcript-variant, reference, missense
rs2240233 - 3,831,527(+) GTACA(A/C)CGACG nc-transcript-variant, reference, missense
rs2240232 - 3,831,451(+) GCGGC(A/G)GGGGC nc-transcript-variant, reference, missense
rs2301843 - 3,820,193(+) TGGGG(C/T)GCTGG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZFR2 Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
nsv509718 CNV Insertion 20534489
nsv910770 CNV Loss 21882294
nsv910777 CNV Loss 21882294
nsv833715 CNV Loss 17160897
dgv3664n71 CNV Loss 21882294
nsv910780 CNV Loss 21882294
esv2717969 CNV Deletion 23290073
esv2717970 CNV Deletion 23290073
esv2071608 CNV Deletion 18987734
esv2743112 CNV Deletion 23290073
esv5059 CNV Deletion 18987735
esv2717971 CNV Deletion 23290073
esv2717972 CNV Deletion 23290073
esv2666653 CNV Deletion 23128226
esv2717974 CNV Deletion 23290073
esv1995150 CNV Deletion 18987734
nsv138020 CNV Loss 16902084
esv991288 CNV Deletion 20482838
esv2717975 CNV Deletion 23290073
esv1602911 CNV Deletion 17803354

Variation tolerance for ZFR2 Gene

Gene Damage Index Score: 11.33; 92.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFR2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFR2 Gene

Disorders for ZFR2 Gene

Relevant External Links for ZFR2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZFR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFR2 Gene

Publications for ZFR2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZFR2 Gene

Sources for ZFR2 Gene