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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFR Gene

protein-coding   GIFtS: 51
GCID: GC05M032354

zinc finger RNA binding protein
 Explore 3 diseases affiliated with
ZFR via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZFR    

Aliases
for ZFR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc Finger RNA Binding Protein1 2
ZFR11 2
HZFR1
M-Phase Phosphoprotein Homolog2 3
Zinc Finger RNA-Binding Protein2

External Ids:    HGNC: 172771   Entrez Gene: 516632   Ensembl: ENSG000000560977   UniProtKB: Q96KR13   

Export aliases for ZFR gene to outside databases

Previous GC identifers: GC05M032141 GC05M032800 GC05M032399 GC05M032390


Summaries
for ZFR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ZFR_HUMAN, Q96KR1
Function: Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic
shuttling of STAU2. Binds to DNA and RNA (By similarity)




Genomic Views
for ZFR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFR gene promoter:
         AhR   HFH-3   Sox5   Pax-6   Pax-2   AP-4   Pax-2a   MEF-2A   FOXI1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZFR promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.3   Ensembl cytogenetic band:  5p13.3   HGNC cytogenetic band: 5p15.2

ZFR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFR gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M032354:  view genomic region     (about GC identifiers)

Start:
 32,354,456 bp from pter      End:
 32,444,867 bp from pter
Size:
 90,412 bases      Orientation:
 minus strand

Proteins
for ZFR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZFR_HUMAN, Q96KR1 (See protein sequence)
Recommended Name: Zinc finger RNA-binding protein  
Size: 1074 amino acids; 117012 Da
Subunit: Found in a cytoplasmic RNP complex with STAU2. Interacts with STAU2. Does not interact with STAU1 (By
similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasmic granule (By similarity).
Chromosome (By similarity). Note=Associated with chromosome foci in meiotic cells. Localizes in somatodendritic
compartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules (By similarity)
Sequence caution: Sequence=AAD40385.1; Type=Erroneous initiation; Sequence=AAH30540.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAI07418.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAB15147.1; Type=Erroneous initiation;
Sequence=CAC40818.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAC40818.1;
Type=Frameshift; Positions=1057;
Secondary accessions: B2RNR5 Q05C08 Q3B7X5 Q6P5A3 Q86UA0 Q9H6V4 Q9NTI1 Q9Y687

Explore the universe of human proteins at neXtProt for ZFR: NX_Q96KR1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96KR1

    • ZFR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057191.2  
    ENSEMBL proteins: 
     ENSP00000265069   ENSP00000422300  

    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZFR

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--


    ZFR for ontologies           About GeneDecksing



    ZFR Antibody Products: 
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    Uscn Antibodies for ZFR
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    Uscn ELISAs and CLIAs for ZFR

    Protein Domains /
    Families
    for ZFR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZFR for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR003604 Znf_U1
     IPR006561 DZF
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96KR1

    ProtoNet protein and cluster: Q96KR1

    1 Blocks protein family: IPB003604 Zn-finger

    UniProtKB/Swiss-Prot: ZFR_HUMAN, Q96KR1
    Similarity: Contains 1 DZF domain


    Function
    for ZFR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZFR_HUMAN, Q96KR1
    Function: Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic
    shuttling of STAU2. Binds to DNA and RNA (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFR
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFR (see all 35):
    hsa-miR-548j hsa-miR-200a hsa-miR-550a* hsa-miR-105 hsa-miR-141 hsa-miR-3613-3p hsa-miR-1183 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ZFR 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFR (see all 4)
    OriGene shRNA RFP: ZFR
    OriGene siRNA: ZFR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFR

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ZFR

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFR 

    Cell Line
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    Search LifeMap BioReagents cell lines for ZFR

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFR

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    ZFR for ontologies           About GeneDecksing


    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Zfr):
     embryogenesis  growth/size  mortality/aging 

    ZFR for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ZFR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Diurnally regulated genes with circadian orthologs
    		Diurnally regulated genes with circadian orthologs1.00


    1 BioSystems Pathway for ZFR 
        Diurnally regulated genes with circadian orthologs


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/26 Interacting proteins for ZFR (Q96KR11, 2, 3 ENSP000002650694) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157961, 3EBI-2560216,EBI-1040141 I2D: score=1 
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    RPAP1Q9BWH63, ENSP000003061234I2D: score=1 STRING: ENSP00000306123
    HNRNPA1P096513, ENSP000003418264I2D: score=1 STRING: ENSP00000341826
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--


    ZFR for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZFR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZFR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFR
    1 Novoseek chemical compound relationship for ZFR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 46.8 6 16890764 (1), 20211283 (1), 1717260 (1), 18519039 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about ZFR 

    Transcripts
    for ZFR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZFR gene: 
    NM_016107.3  

    Unigene Cluster for ZFR:

    Zinc finger RNA binding protein
    Hs.435231  [show with all ESTs]
    Unigene Representative Sequence: NM_016107
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265069(uc010ium.1 uc011cny.1 uc003jhr.1) ENST00000514356
    ENST00000502988 ENST00000510369 ENST00000507465 ENST00000505366(uc010iun.1)
    ENST00000505204

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ZFR
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFR
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFR (see all 35):
    hsa-miR-548j hsa-miR-200a hsa-miR-550a* hsa-miR-105 hsa-miR-141 hsa-miR-3613-3p hsa-miR-1183 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ZFR 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFR (see all 4)
    OriGene shRNA RFP: ZFR
    OriGene siRNA: ZFR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFR
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZFR (NM_001145640)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFR 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFR

    Additional cDNA sequence: 

    AF100742.1 AJ314790.1 AK025481.1 AK055938.1 AK123306.1 AK292214.1 AK295297.1 AK307808.1 
    AK309638.1 AL137258.1 BC017879.1 BC030540.1 BC038973.1 BC051893.1 BC062986.1 BC107417.1 
    BC137084.1 BC137085.1 U00951.1 U00960.1 

    9 DOTS entries:

    DT.447844  DT.91759257  DT.40111860  DT.95123261  DT.101966650  DT.120816384  DT.120816377  DT.112477 
    DT.121366606 

    24/308 AceView cDNA sequences (see all 308):

    CA447852 AA007333 AA133606 AW292228 BC062986 BQ219704 AL162096 BC017879 
    CB305727 AI128362 BQ694032 BX115375 BF110685 AI239441 BM769158 AI457645 
    AW003071 AW245266 BU677940 AI198040 BM724938 BF110058 BM764873 CA388889 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZFR (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^
    SP1:                                                                                                                                      -           -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                -                                                                           
    SP5:                                                                                                                                -     -           -         

    ExUns: 19 ^ 20
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for ZFR

    Expression
    for ZFR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZFR expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemEarly GonadTestis Somatic CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZFR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFR

    SOURCE GeneReport for Unigene cluster: Hs.435231

    UniProtKB/Swiss-Prot: ZFR_HUMAN, Q96KR1
    Tissue specificity: Expressed in lung, liver, lymphocytes, heart, pancreas, placenta, brain and kidney

        SABiosciences Custom PCR Arrays for ZFR
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFR

    Orthologs
    for ZFR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ZFR gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zfr1 , 5 zinc finger RNA binding protein1, 5 92.83(n)1
    97.77(a)1    		   15 (5.90 cM)5
    227631  NM_011767.21  NP_035897.21 
     121178315 
    chicken
    (Gallus gallus)    		 Aves ZFR1 zinc finger RNA binding protein 84.35(n)
    93.16(a)    		   427424  XM_424997.3  XP_424997.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ZFR6
    		 --
    		 89(a)
    		 1 ↔ 1
    		 GL343335.1(121245-160131)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.53702 Xenopus laevis, Similar to zinc finger RNA binding more 79.9(n)    BC042260.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb25b082 wufb25b08 78.9(n)   321659  BC059198.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Zn72D6
    		 Zinc-finger protein at 72D
    		 42(a)
    		 1 → many
    		 3L(16099694-16105726)
    worm
    (Caenorhabditis elegans)    		 Secernentea Y95B8A.71 hypothetical protein 46.2(n)
    36.95(a)    		   171673  NM_058385.2  NP_490786.2 


    ENSEMBL Gene Tree for ZFR (if available)
    TreeFam Gene Tree for ZFR (if available) 

    Paralogs
    for ZFR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFR gene
    ZFR22  ILF22  STRBP2  ILF32  
    4 SIMAP similar genes for ZFR using alignment to 5 protein entries:     ZFR_HUMAN (see all proteins):
    ILF3    DKFZp434P151    STRBP    ZFR2

    ZFR for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZFR
    PGOHUM00000238882 PGOHUM00000241347


    Genomic Variants
    for ZFR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1631 NCBI SNPs in ZFR are shown (see all 1631)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1159806281,2
    		F,--32353963(+) AAGGAG/AAGTAA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs48674311,2
    		C,F,H,--32354066(+) GGACCA/GGAAGT 1 -- ds500110Minor allele frequency- G:0.20NS EA NA WA 664
    rs29109251,2
    		C,F,A,H,--32354188(+) TTTTGA/GCAATT 1 -- ds50017Minor allele frequency- G:0.03NS EA WA 718
    rs113723591,2
    		C,--32354295(+) CCCTC-/TTAAGA 1 -- ds50010--------
    rs2002050361,2
    		C--32354296(-) TCTTAA/GAGGGC 1 -- ds50010--------
    rs339852011,2
    		C--32354297(+) CCTCTT/-AAGAC 1 -- ds50011Minor allele frequency- -:0.00NA 2
    rs1867114541,2
    		--32354314(+) GGAAGA/GTTCTG 1 -- ds50010--------
    rs1899978431,2
    		--32354359(+) AGAAAG/TAAATT 1 -- ds50010--------
    rs1824579701,2
    		--32354461(+) TAAATC/TTGAAT 1 -- ut310--------
    rs1871512961,2
    		--32354645(+) TGTAAC/TTTTTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZFR (32354456 - 32444867 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZFR
         1 CNV: 3552

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    Disorders / Diseases
    for ZFR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZFR for disorders           About GeneDecksing

    3 diseases for ZFR:    About MalaCards
    cri-du-chat syndrome    asthma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ZFR:
    Cri-Du-Chat syndrome

    Export disorders for ZFR gene to outside databases

    Publications
    for ZFR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFR gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with ZFR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of the human single copy homologue of the mouse zinc finger protein zfr. (PubMed id 11574164)1, 2, 3 Kleines M.... Schaade L. (2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. (PubMed id 22446626)1 Close P.... Svejstrup J.Q. (2012)
    5. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)

    External Searches for ZFR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZFR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51663 HGNC: 17277 AceView: ZFR Ensembl:ENSG00000056097 euGenes: HUgn51663
    ECgene: ZFR H-InvDB: ZFR

    Other Databases showing ZFR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZFR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFR Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZFR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZFR gene:
    Search GeneIP for patents involving ZFR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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