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Aliases for ZFR Gene

Aliases for ZFR Gene

  • Zinc Finger RNA Binding Protein 2 3
  • M-Phase Phosphoprotein Homolog 3 4
  • HZFR 3 4
  • Zinc Finger RNA-Binding Protein 3
  • SPG71 3
  • ZFR1 3

External Ids for ZFR Gene

Summaries for ZFR Gene

GeneCards Summary for ZFR Gene

ZFR (Zinc Finger RNA Binding Protein) is a Protein Coding gene. Diseases associated with ZFR include autosomal recessive spastic paraplegia type 71 and cri-du-chat syndrome. Among its related pathways are Diurnally regulated genes with circadian orthologs. GO annotations related to this gene include RNA binding. An important paralog of this gene is ZFR2.

UniProtKB/Swiss-Prot for ZFR Gene

  • Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFR Gene

Genomics for ZFR Gene

Genomic Location for ZFR Gene

32,354,350 bp from pter
32,444,761 bp from pter
90,412 bases
Minus strand

Genomic View for ZFR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFR Gene

Regulatory Elements for ZFR Gene

Proteins for ZFR Gene

  • Protein details for ZFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger RNA-binding protein
    Protein Accession:
    Secondary Accessions:
    • B2RNR5
    • Q05C08
    • Q3B7X5
    • Q6P5A3
    • Q86UA0
    • Q9H6V4
    • Q9NTI1
    • Q9Y687

    Protein attributes for ZFR Gene

    1074 amino acids
    Molecular mass:
    117012 Da
    Quaternary structure:
    • Found in a cytoplasmic RNP complex with STAU2. Interacts with STAU2. Does not interact with STAU1 (By similarity).
    • Sequence=AAD40385.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH30540.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI07418.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB15147.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC40818.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAC40818.1; Type=Frameshift; Positions=1057; Evidence={ECO:0000305};

neXtProt entry for ZFR Gene

Proteomics data for ZFR Gene at MOPED

Post-translational modifications for ZFR Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys730 and Lys796

Other Protein References for ZFR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFR Gene

Domains for ZFR Gene

Protein Domains for ZFR Gene


  • Contains 1 DZF domain.:
    • Q96KR1
genes like me logo Genes that share domains with ZFR: view

No data available for Gene Families for ZFR Gene

Function for ZFR Gene

Molecular function for ZFR Gene

UniProtKB/Swiss-Prot Function: Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity).

Gene Ontology (GO) - Molecular Function for ZFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 20195357
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZFR: view

Phenotypes for ZFR Gene

genes like me logo Genes that share phenotypes with ZFR: view

miRNA for ZFR Gene

miRTarBase miRNAs that target ZFR

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFR Gene

Localization for ZFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFR Gene

Nucleus. Cytoplasm. Cytoplasmic granule. Chromosome. Note=Associated with chromosome foci in meiotic cells. Localizes in somatodendritic compartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for ZFR Gene COMPARTMENTS Subcellular localization image for ZFR gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZFR: view

Pathways for ZFR Gene

genes like me logo Genes that share pathways with ZFR: view

Pathways by source for ZFR Gene

1 BioSystems pathway for ZFR Gene

Gene Ontology (GO) - Biological Process for ZFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with ZFR: view

Compounds for ZFR Gene

(1) Novoseek inferred chemical compound relationships for ZFR Gene

Compound -log(P) Hits PubMed IDs
zinc 46.8 6
genes like me logo Genes that share compounds with ZFR: view

Transcripts for ZFR Gene

Unigene Clusters for ZFR Gene

Zinc finger RNA binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFR Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^
SP1: - -
SP4: -
SP5: - - -
SP6: -

ExUns: 19 ^ 20

Relevant External Links for ZFR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFR Gene

mRNA expression in normal human tissues for ZFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFR Gene

SOURCE GeneReport for Unigene cluster for ZFR Gene Hs.435231

mRNA Expression by UniProt/SwissProt for ZFR Gene

Tissue specificity: Expressed in lung, liver, lymphocytes, heart, pancreas, placenta, brain and kidney.
genes like me logo Genes that share expressions with ZFR: view

Orthologs for ZFR Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFR 36
  • 99.84 (n)
  • 99.9 (a)
ZFR 37
  • 99 (a)
(Bos Taurus)
Mammalia ZFR 36
  • 95.42 (n)
  • 98.52 (a)
ZFR 37
  • 99 (a)
(Canis familiaris)
Mammalia ZFR 36
  • 96.02 (n)
  • 99.07 (a)
ZFR 37
  • 97 (a)
(Mus musculus)
Mammalia Zfr 36
  • 92.83 (n)
  • 97.77 (a)
Zfr 16
Zfr 37
  • 98 (a)
(Monodelphis domestica)
Mammalia ZFR 37
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia ZFR 37
  • 94 (a)
(Rattus norvegicus)
Mammalia Zfr 36
  • 93.48 (n)
  • 97.95 (a)
(Gallus gallus)
Aves -- 37
  • 91 (a)
-- 37
  • 93 (a)
ZFR 36
  • 84.35 (n)
  • 93.16 (a)
(Anolis carolinensis)
Reptilia ZFR 37
  • 90 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5370 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6545 36
zfr 36
  • 77.06 (n)
  • 87.49 (a)
(Danio rerio)
Actinopterygii wufb25b08 36
zfr 36
  • 71.86 (n)
  • 80 (a)
zfr 37
  • 80 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001905 36
  • 50.84 (n)
  • 49.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Zn72D 36
  • 49.05 (n)
  • 47.15 (a)
Zn72D 37
  • 44 (a)
(Caenorhabditis elegans)
Secernentea Y95B8A.8 36
  • 48.47 (n)
  • 40.84 (a)
Y95B8A.8 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9218 37
  • 23 (a)
Species with no ortholog for ZFR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFR Gene

Gene Tree for ZFR (if available)
Gene Tree for ZFR (if available)

Paralogs for ZFR Gene

Paralogs for ZFR Gene

Selected SIMAP similar genes for ZFR Gene using alignment to 5 proteins: Pseudogenes for ZFR Gene

genes like me logo Genes that share paralogs with ZFR: view

Variants for ZFR Gene

Sequence variations from dbSNP and Humsavar for ZFR Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs178935 -- 32,417,589(-) TACTG(C/T)GTTTA intron-variant
rs183443 -- 32,444,180(+) TCCGG(A/G)CCGAG intron-variant
rs186559 -- 32,421,808(-) ATGTT(A/G)GTTTT intron-variant, upstream-variant-2KB
rs324428 -- 32,419,744(-) TAGCC(A/G)TTGCT intron-variant
rs324429 -- 32,436,123(-) GGTTA(C/G)CAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFR Gene

Variant ID Type Subtype PubMed ID
dgv1792e1 CNV Complex 17122850
dgv6030n71 CNV Loss 21882294
esv2730025 CNV Deletion 23290073
esv2730026 CNV Deletion 23290073
esv2730027 CNV Deletion 23290073
esv2730030 CNV Deletion 23290073
esv2730031 CNV Deletion 23290073
esv2730032 CNV Deletion 23290073
esv2730033 CNV Deletion 23290073
esv2730034 CNV Deletion 23290073
esv2730035 CNV Deletion 23290073
esv2730036 CNV Deletion 23290073
esv2730037 CNV Deletion 23290073
esv2730038 CNV Deletion 23290073
esv2730039 CNV Deletion 23290073

Relevant External Links for ZFR Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for ZFR Gene

(1) University of Copenhagen DISEASES for ZFR Gene

genes like me logo Genes that share disorders with ZFR: view

No data available for UniProtKB/Swiss-Prot for ZFR Gene

Publications for ZFR Gene

  1. Cloning and expression of the human single copy homologue of the mouse zinc finger protein zfr. (PMID: 11574164) Kleines M. … Schaade L. (Gene 2001) 2 3 4
  2. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. (PMID: 24482476) Novarino G. … Gleeson J.G. (Science 2014) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Human RNPS1 and its associated factors: a versatile alternative pre- mRNA splicing regulator in vivo. (PMID: 14729963) Sakashita E. … Mayeda A. (Mol. Cell. Biol. 2004) 3
  5. Nucleolar proteome dynamics. (PMID: 15635413) Andersen J.S. … Mann M. (Nature 2005) 3

Products for ZFR Gene

Sources for ZFR Gene

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