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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFR Gene

protein-coding   GIFtS: 51
GCID: GC05M032354

Zinc Finger RNA Binding Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger RNA Binding Protein1 2
hZFR2 3
M-Phase Phosphoprotein Homolog2 3
ZFR12
Zinc Finger RNA-Binding Protein2

External Ids:    HGNC: 172771   Entrez Gene: 516632   Ensembl: ENSG000000560977   UniProtKB: Q96KR13   

Export aliases for ZFR gene to outside databases

Previous GC identifers: GC05M032141 GC05M032800 GC05M032399 GC05M032390


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZFR Gene: 
ZFR (zinc finger RNA binding protein) is a protein-coding gene. Diseases associated with ZFR include cri-du-chat syndrome, and asthma. GO annotations related to this gene include RNA binding and DNA binding. An important paralog of this gene is ZFR2.

UniProtKB/Swiss-Prot: ZFR_HUMAN, Q96KR1
Function: Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic
shuttling of STAU2. Binds to DNA and RNA (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFR gene promoter:
         AhR   HFH-3   Sox5   Pax-6   Pax-2   AP-4   Pax-2a   MEF-2A   FOXI1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFR promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.3   Ensembl cytogenetic band:  5p13.3   HGNC cytogenetic band: 5p15.2

ZFR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFR gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M032354:  view genomic region     (about GC identifiers)

Start:
32,354,456 bp from pter      End:
32,444,867 bp from pter
Size:
90,412 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZFR_HUMAN, Q96KR1 (See protein sequence)
Recommended Name: Zinc finger RNA-binding protein  
Size: 1074 amino acids; 117012 Da
Subunit: Found in a cytoplasmic RNP complex with STAU2. Interacts with STAU2. Does not interact with STAU1 (By
similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasmic granule (By similarity).
Chromosome (By similarity). Note=Associated with chromosome foci in meiotic cells. Localizes in somatodendritic
compartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules (By
similarity)
Sequence caution: Sequence=AAD40385.1; Type=Erroneous initiation; Sequence=AAH30540.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAI07418.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAB15147.1; Type=Erroneous
initiation; Sequence=CAC40818.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAC40818.1; Type=Frameshift; Positions=1057;
Secondary accessions: B2RNR5 Q05C08 Q3B7X5 Q6P5A3 Q86UA0 Q9H6V4 Q9NTI1 Q9Y687

Explore the universe of human proteins at neXtProt for ZFR: NX_Q96KR1

Explore proteomics data for ZFR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96KR1

  • ZFR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFR Protein Expression
    REFSEQ proteins: NP_057191.2  
    ENSEMBL proteins: 
     ENSP00000265069   ENSP00000422300  

    Human Recombinant Protein Products for ZFR: 
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    OriGene Custom MassSpec 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZFR 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--

    ZFR for ontologies           About GeneDecksing



    ZFR Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for ZFR 

    Assay Products for ZFR: 
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    Cloud-Clone Corp. ELISAs for ZFR 
    Cloud-Clone Corp. CLIAs for ZFR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR003604 Znf_U1
     IPR006561 DZF
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96KR1

    ProtoNet protein and cluster: Q96KR1

    1 Blocks protein domain: IPB003604 Zn-finger

    UniProtKB/Swiss-Prot: ZFR_HUMAN, Q96KR1
    Similarity: Contains 1 DZF domain


    ZFR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFR_HUMAN, Q96KR1
    Function: Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic
    shuttling of STAU2. Binds to DNA and RNA (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
         
    ZFR for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zfr):
     embryogenesis  growth/size  mortality/aging 

    ZFR for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZFR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZFR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZFR 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFR
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFR (see all 35):
    hsa-miR-548j hsa-miR-200a hsa-miR-550a* hsa-miR-105 hsa-miR-141 hsa-miR-3613-3p hsa-miR-1183 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidZFR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZFR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFR

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ZFR
    Sirion Biotech Customized adenovirus for overexpression of ZFR

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZFR (NM_001145640)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFR
    Sirion Biotech Customized lentivirus for stable overexpression of ZFR 
                         Customized lentivirus expression plasmids for stable overexpression of ZFR 

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    Search LifeMap BioReagents cell lines for ZFR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZFR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs


    1 BioSystems Pathway for ZFR
        Diurnally regulated genes with circadian orthologs


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/26 Interacting proteins for ZFR (Q96KR11, 2, 3 ENSP000002650694) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157961, 3EBI-2513582,EBI-1040141 I2D: score=1 
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    RPAP1Q9BWH63, ENSP000003061234I2D: score=1 STRING: ENSP00000306123
    HNRNPA1P096513, ENSP000003418264I2D: score=1 STRING: ENSP00000341826
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--

    ZFR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZFR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFR

    1 Novoseek inferred chemical compound relationship for ZFR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 46.8 6 16890764 (1), 20211283 (1), 1717260 (1), 18519039 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about ZFR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFR gene: 
    NM_016107.3  

    Unigene Cluster for ZFR:

    Zinc finger RNA binding protein
    Hs.435231  [show with all ESTs]
    Unigene Representative Sequence: NM_016107
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265069(uc010ium.1 uc011cny.1 uc003jhr.1) ENST00000514356
    ENST00000502988 ENST00000510369 ENST00000507465 ENST00000505366(uc010iun.1)
    ENST00000505204
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFR
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFR (see all 35):
    hsa-miR-548j hsa-miR-200a hsa-miR-550a* hsa-miR-105 hsa-miR-141 hsa-miR-3613-3p hsa-miR-1183 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidZFR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZFR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFR
    Clone
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    OriGene clones in human, mouse for ZFR (see all 6)
    OriGene ORF clones in mouse, rat for ZFR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZFR (NM_001145640)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFR
    Sirion Biotech Customized lentivirus for stable overexpression of ZFR 
                         Customized lentivirus expression plasmids for stable overexpression of ZFR 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZFR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFR

    Additional mRNA sequence: 

    AF100742.1 AJ314790.1 AK025481.1 AK055938.1 AK123306.1 AK292214.1 AK295297.1 AK307808.1 
    AK309638.1 AL137258.1 BC017879.1 BC030540.1 BC038973.1 BC051893.1 BC062986.1 BC107417.1 
    BC137084.1 BC137085.1 U00951.1 U00960.1 

    9 DOTS entries:

    DT.447844  DT.91759257  DT.40111860  DT.95123261  DT.101966650  DT.120816384  DT.120816377  DT.112477 
    DT.121366606 

    24/308 AceView cDNA sequences (see all 308):

    AA928638 BX955036 AI192659 AU280577 AI435114 AA977494 BC051893 AI459130 
    AA450197 AI554259 AA506082 BM460118 AA007333 CA447852 CB305727 AA133606 
    AW292228 BC062986 AL162096 BQ219704 BC017879 BQ694032 BF110058 BM724938 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZFR (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^
    SP1:                                                                                                                                      -           -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                -                                                                           
    SP5:                                                                                                                                -     -           -         

    ExUns: 19 ^ 20
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for ZFR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFR expression in normal human tissues (normalized intensities)      ZFR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZFR Expression
    About this image


    ZFR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad

    See ZFR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFR

    SOURCE GeneReport for Unigene cluster: Hs.435231

    UniProtKB/Swiss-Prot: ZFR_HUMAN, Q96KR1
    Tissue specificity: Expressed in lung, liver, lymphocytes, heart, pancreas, placenta, brain and kidney

        SABiosciences Custom PCR Arrays for ZFR
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZFR gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfr1 , 5 zinc finger RNA binding protein1, 5 92.83(n)1
    97.77(a)1
      15 (5.90 cM)5
    227631  NM_011767.21  NP_035897.21 
     121178315 
    chicken
    (Gallus gallus)
    Aves ZFR1 zinc finger RNA binding protein 84.35(n)
    93.16(a)
      427424  XM_424997.3  XP_424997.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZFR6
    Uncharacterized protein
    90(a)
    1 ↔ 1
    GL343335.1(121245-160141)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.53702 Xenopus laevis, Similar to zinc finger RNA binding more 79.9(n)    BC042260.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb25b082 wufb25b08 78.9(n)   321659  BC059198.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Zn72D6
    Zinc-finger protein at 72D
    44(a)
    1 → many
    3L(16099694-16105726)
    worm
    (Caenorhabditis elegans)
    Secernentea Y95B8A.71 hypothetical protein 46.2(n)
    36.95(a)
      171673  NM_058385.2  NP_490786.2 


    ENSEMBL Gene Tree for ZFR (if available)
    TreeFam Gene Tree for ZFR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFR gene
    ZFR22  ILF22  STRBP2  ILF32  
    4 SIMAP similar genes for ZFR using alignment to 5 protein entries:     ZFR_HUMAN (see all proteins):
    ILF3    DKFZp434P151    STRBP    ZFR2

    ZFR for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZFR
    PGOHUM00000238882 PGOHUM00000241347


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1922 SNPs in ZFR are shown (see all 1922)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs756056981,2
    C--32309243(+) CACAA-/CAGACTT 1 -- int10--------
    rs1159806281,2
    F--32353963(+) AAGGAG/AAGTAA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs48674311,2
    C,F,H--32354066(+) GGACCA/GGAAGT 1 -- ds500110Minor allele frequency- G:0.20NS EA NA WA 664
    rs29109251,2
    C,F,A,H--32354188(+) ttttgA/Gcaatt 1 -- ds50017Minor allele frequency- G:0.03NS EA WA 718
    rs2002050361,2
    C--32354296(-) TCTTAA/GAGGGC 1 -- ds50010--------
    rs1867114541,2
    --32354314(+) GGAAGA/GTTCTG 1 -- ds50010--------
    rs1899978431,2
    --32354359(+) AGAAAG/TAAATT 1 -- ds50010--------
    rs1824579701,2
    --32354461(+) TAAATC/TTGAAT 1 -- ut310--------
    rs1871512961,2
    --32354645(+) TGTAAC/TTTTTC 1 -- ut310--------
    rs560461821,2
    C--32354729(+) TCTGTC/TTTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZFR (32354456 - 32444867 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for ZFR (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2730032CNV Deletion23290073
    esv2730039CNV Deletion23290073
    esv2730031CNV Deletion23290073
    esv2730027CNV Deletion23290073
    esv2730038CNV Deletion23290073
    esv2730030CNV Deletion23290073
    esv2730033CNV Deletion23290073
    esv2730035CNV Deletion23290073
    esv2730037CNV Deletion23290073
    esv2730025CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for ZFR:    About MalaCards
    cri-du-chat syndrome    asthma    endotheliitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ZFR:
    Cri-Du-Chat syndrome

    ZFR for disorders           About GeneDecksing


    Export disorders for ZFR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFR gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with ZFR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of the human single copy homologue of the mouse zinc finger protein zfr. (PubMed id 11574164)1, 2, 3 Kleines M.... Schaade L. (2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    4. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PubMed id 22751105)1 Chu L....Tomasson M.H. (2012)
    7. DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. (PubMed id 22446626)1 Close P.... Svejstrup J.Q. (2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51663 HGNC: 17277 AceView: ZFR Ensembl:ENSG00000056097 euGenes: HUgn51663
    ECgene: ZFR H-InvDB: ZFR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFR gene:
    Search GeneIP for patents involving ZFR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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