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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFPM2 Gene

protein-coding   GIFtS: 56
GCID: GC08P106400

zinc finger protein, FOG family member 2

(Previous names: zinc finger protein, multitype 2 )
 Explore 17 diseases affiliated with
ZFPM2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZFPM2    

Aliases
for ZFPM2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc Finger Protein, FOG Family Member 21 2     Zinc Finger Protein 89B2 3
FOG21 2 3 5     FOG-22 3
ZNF89B1 2 3     DIH32 5
HFOG-21     Friend Of GATA22
ZC2HC11B1 2     Transcription Factor GATA4, Modulator Of2
Zinc Finger Protein, Multitype 21 2     Zinc Finger Protein ZFPM22
Friend Of GATA 22 3     Zinc Finger Protein Multitype 23
Friend Of GATA Protein 22 3     

External Ids:    HGNC: 167001   Entrez Gene: 234142   Ensembl: ENSG000001699467   OMIM: 6036935   UniProtKB: Q8WW383   

Export aliases for ZFPM2 gene to outside databases

Previous GC identifers: GC08P106398 GC08P105999 GC08P106287 GC08P101532


Summaries
for ZFPM2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ZFPM2:
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors.
The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and
cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of
GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an
alternatively spliced product but this information is not yet fully supported by the sequence. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: FOG2_HUMAN, Q8WW38
Function: Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels
from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the
formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can
both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in
gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By
similarity)

Gene Wiki entry for ZFPM2


Genomic Views
for ZFPM2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFPM2 gene promoter:
         ER-alpha   NF-1   p300   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   GATA-1   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZFPM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFPM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFPM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23   Ensembl cytogenetic band:  8q23.1   HGNC cytogenetic band: 8q23

ZFPM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFPM2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P106400:  view genomic region     (about GC identifiers)

Start:
 106,330,920 bp from pter      End:
 106,816,767 bp from pter
Size:
 485,848 bases      Orientation:
 plus strand

Proteins
for ZFPM2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FOG2_HUMAN, Q8WW38 (See protein sequence)
Recommended Name: Zinc finger protein ZFPM2  
Size: 1151 amino acids; 128159 Da
Subunit: Interacts with the N-terminal zinc-finger of GATA4, GATA5 and probably GATA6. Interacts with retinoid nuclear
receptor RXRA when ligand bound (By similarity). Interacts with corepressor CTBP2; this interaction is however not
essential for corepressor activity. Able to bind GATA1 in vitro. Interacts with NR2F2 and NR2F6 (By similarity)
Subcellular location: Nucleus
Secondary accessions: Q32MA6 Q9NPL7 Q9NPS4 Q9UNI5
Alternative splicing: 2 isoforms:  Q8WW38-1   Q8WW38-2   (Sequence incomplete. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFPM2: NX_Q8WW38

Post-translational modifications:

  • Sumoylation reduces transcriptional repression activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WW38

    • ZFPM2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036214.2  
    ENSEMBL proteins: 
     ENSP00000384179   ENSP00000430757   ENSP00000428149   ENSP00000428720   ENSP00000367733  
    Reactome Protein details: Q8WW38
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZFPM2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--


    ZFPM2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZFPM2

    Protein Domains /
    Families
    for ZFPM2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZFPM2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8WW38

    ProtoNet protein and cluster: Q8WW38

    UniProtKB/Swiss-Prot: FOG2_HUMAN, Q8WW38
    Domain: The CCHC-type zinc fingers 1, 5, 6 and 8 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to
    the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity)
    Similarity: Belongs to the FOG (Friend of GATA) family
    Similarity: Contains 3 C2H2-type zinc fingers
    Similarity: Contains 5 C2HC-type zinc fingers


    Function
    for ZFPM2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FOG2_HUMAN, Q8WW38
    Function: Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels
    from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the
    formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can
    both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in
    gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By
    similarity)

    miRNA
    Products:            		miRTarBase miRNAs that target ZFPM2:
    hsa-mir-141 (MIRT004621), hsa-mir-200c (MIRT004624), hsa-mir-200b (MIRT004623), hsa-mir-200a (MIRT004622), hsa-mir-429 (MIRT004625)

    OriGene 3'-UTR Clone: ZFPM2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFPM2
    8/140 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFPM2 (see all 140):
    hsa-miR-579 hsa-miR-361-5p hsa-miR-520f hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-200b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: ZFPM2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFPM2 (see all 7)
    OriGene shRNA RFP: ZFPM2
    OriGene siRNA: ZFPM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFPM2

    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for ZFPM2

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFPM2

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001071nucleic acid binding transcription factor activity IEA--
    GO:0001105RNA polymerase II transcription coactivator activity NAS10438528
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity IDA10438528


    ZFPM2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for ZFPM2: Zfpm2tm1Sho Zfpm2tm1Jml
         12 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Zfpm2):
     cardiovascular system  cellular  endocrine/exocrine gland  homeostasis/metabolism  integument 
     liver/biliary system  mortality/aging  muscle  no phenotypic analysis  normal 
     reproductive system  respiratory system 

    ZFPM2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ZFPM2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Factors involved in megakaryocyte development and platelet production
    		Factors involved in megakaryocyte development and platelet production1.00
    2Platelet activation, signaling and aggregation
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZFPM2
        Hemostasis
    Factors involved in megakaryocyte development and platelet production



    ZFPM2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFPM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/22 Interacting proteins for ZFPM2 (Q8WW383 ENSP000003841794) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GATA3P237713, ENSP000003686324I2D: score=1 STRING: ENSP00000368632
    H3F3AP842433I2D: score=1 
    H3F3BP842433I2D: score=1 
    MTA1Q133303, ENSP000003336334I2D: score=1 STRING: ENSP00000333633
    MTA2O947763, ENSP000002788234I2D: score=1 STRING: ENSP00000278823
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001570vasculogenesis IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0003148outflow tract septum morphogenesis IMP--
    GO:0003221right ventricular cardiac muscle tissue morphogenesis IMP--


    ZFPM2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZFPM2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZFPM2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFPM2
    1 Novoseek chemical compound relationship for ZFPM2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 55.7 4 10801815 (1), 15507435 (1)

    Search CenterWatch for drugs/clinical trials and news about ZFPM2 / FOG2 

    Transcripts
    for ZFPM2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZFPM2 gene: 
    NM_012082.3  

    Unigene Cluster for ZFPM2:

    Zinc finger protein, FOG family member 2
    Hs.431009  [show with all ESTs]
    Unigene Representative Sequence: NM_012082
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407775(uc003ymd.3 uc011lhs.2) ENST00000520492 ENST00000520027
    ENST00000524235 ENST00000511341 ENST00000522160 ENST00000517361 ENST00000522296
    ENST00000378472

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ZFPM2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFPM2
    8/140 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFPM2 (see all 140):
    hsa-miR-579 hsa-miR-361-5p hsa-miR-520f hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-200b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: ZFPM2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFPM2 (see all 7)
    OriGene shRNA RFP: ZFPM2
    OriGene siRNA: ZFPM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFPM2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFPM2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFPM2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ZFPM2 (NM_012082)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFPM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFPM2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFPM2
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    Additional cDNA sequence: 

    AB073894.1 AF119334.1 AK296997.1 AK303058.1 AK316426.1 AL389974.1 AL389987.1 AL389988.1 
    AL389989.1 BC020928.1 BC109222.1 BC109223.1 

    5 DOTS entries:

    DT.211298  DT.95103377  DT.40208382  DT.99961666  DT.75169281 

    24/35 AceView cDNA sequences (see all 35):

    BQ941160 F10338 BC020928 AL389987 AF119334 BM718680 AL389989 NM_012082 
    AA442019 F12732 AL389974 BX499987 AI926034 AL389988 BP336081 AI269852 
    AL118627 CD511818 BU742351 CF780708 R49439 AI370886 AA975109 R73534 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZFPM2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                          -     -     -                     
    SP2:                                                            


    ECgene alternative splicing isoforms for ZFPM2

    Expression
    for ZFPM2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFPM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATATGGATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZFPM2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEpicardiumEpicardial Progenitors CellsEpicardium
    TestisTestis CordPre-Sertoli CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    Posterior foregut-like cells (A scalable, suspensi...)
    Embryoid bodies (Two-step protocol fo...)
    Beating cell clusters (Spontaneous differen...)

    See ZFPM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFPM2

    SOURCE GeneReport for Unigene cluster: Hs.431009

    UniProtKB/Swiss-Prot: FOG2_HUMAN, Q8WW38
    Tissue specificity: Widely expressed at low level

        SABiosciences Expression via Pathway-Focused PCR Array including ZFPM2: 
              Stem Cell Transcription Factors in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFPM2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFPM2

    Orthologs
    for ZFPM2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ZFPM2 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zfpm21 , 5 zinc finger protein, multitype 21, 5 89.08(n)1
    93.92(a)1    		   15 (15.74 cM)5
    227621  NM_011766.51  NP_035896.11 
     406550425 
    chicken
    (Gallus gallus)    		 Aves ZFPM21 zinc finger protein, multitype 2 83.44(n)
    89.82(a)    		   420269  XM_418380.3  XP_418380.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ZFPM26
    		 --
    		 87(a)
    		 1 ↔ 1
    		 4(12446060-12453927)
    zebrafish
    (Danio rerio)    		 Actinopterygii zfpm2a1 zinc finger protein, multitype 2a 66.43(n)
    64.2(a)    		   568996  NM_001039635.1  NP_001034724.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ush6
    		 u-shaped
    		 12(a)
    		 1 → many
    		 2L(476220-540560)


    ENSEMBL Gene Tree for ZFPM2 (if available)
    TreeFam Gene Tree for ZFPM2 (if available) 

    Paralogs
    for ZFPM2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFPM2 gene
    ZFPM12  

    ZFPM2 for paralogs           About GeneDecksing



    Genomic Variants
    for ZFPM2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7537 NCBI SNPs in ZFPM2 are shown (see all 7537)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1219086011,2
    		C,F,pathogenic101753646(+) ATCAGA/GGGAAA 2 E G mis11Minor allele frequency- G:0.01EU 593
    rs283745441,2
    		C,F,H,pathogenic102135557(+) CCTCCA/GGTAAC 2 S G mis115Minor allele frequency- G:0.10NS NA EA WA CSA 1414
    rs1219086031,2
    		C,pathogenic102135695(+) CATACA/CTGGTC 2 M L mis10--------
    rs776250001,2
    		C,F,--101530962(+) AGTCAA/GCCAAG 1 -- us2k11Minor allele frequency- G:0.20WA 118
    rs29574381,2
    		C--101532740(+) ggcggC/Gggcgg 1 -- us2k10--------
    rs758206461,2
    		C,F,--101534273(+) CAAGTA/GCTGGA 1 -- int11Minor allele frequency- G:0.05WA 118
    rs780124001,2
    		C,F,--101534840(+) TACATA/GTGTAT 1 -- int11Minor allele frequency- G:0.04WA 118
    rs770474751,2
    		F,--101535122(+) CGCAGA/TTGGAG 1 -- int11Minor allele frequency- T:0.03EA 120
    rs778161511,2
    		--101536792(+) CTTGCA/GCATTG 1 -- int10--------
    rs126763671,2
    		H--101537515(+) ATCTAA/GGAATA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZFPM2 (106330920 - 106580920 bp, first 250kb of ZFPM2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 16 variations for ZFPM2
         5 CNVs: 95616 100447 100446 82718 95615
         11 Indels: 13097 82719 47421 28731 65221 41910 13098 95617 62832 47422 65222
    Human Gene Mutation Database (HGMD): ZFPM2

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    Disorders / Diseases
    for ZFPM2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZFPM2 for disorders           About GeneDecksing

    OMIM gene information: 603693   
    OMIM disorders: 187500  610187  
    UniProtKB/Swiss-Prot: FOG2_HUMAN, Q8WW38
  • Defects in ZFPM2 may be a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly
    • which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right
    side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due
    to inadequate oxygenation. Surgical correction is emergent
  • Defects in ZFPM2 are the cause of diaphragmatic hernia 3 (DIH3) [MIM:610187]; a form of congenital
    • diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm
    associated with often lethal pulmonary hypoplasia and pulmonary hypertension

    17 diseases for ZFPM2:    About MalaCards
    double outlet right ventricle    diaphragmatic eventration    diaphragmatic hernia 3    congenital diaphragmatic hernia
    gonadal dysgenesis    tricuspid atresia    hdr syndrome    fryns syndrome
    tetralogy of fallot    hernia    germ cell tumor    hematopoiesis
    hypoparathyroidism    ataxia    neuroblastoma    thyroiditis
    carcinoma

    4 diseases from the University of Copenhagen DISEASES database for ZFPM2:
    Congenital diaphragmatic hernia     Tetralogy of Fallot     Diaphragmatic eventration     Ventricular septal defect

    1 Novoseek disease relationship for ZFPM2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 10999851 (2), 19969558 (1)

    Genetic Association Database (GAD): ZFPM2
    Human Genome Epidemiology (HuGE) Navigator: ZFPM2 (3 documents)

    Export disorders for ZFPM2 gene to outside databases

    Publications
    for ZFPM2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFPM2 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with ZFPM2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation. (PubMed id 10438528)1, 2, 3 Holmes M.... Chong B. (1999)
    2. Fog2 is required for normal diaphragm and lung development in mice and humans. (PubMed id 16103912)1, 2 Ackerman K.G.... Beier D.R. (2005)
    3. ZFPM2/FOG2 and HEY2 genes analysis in nonsyndromic tricuspid atresia. (PubMed id 15643620)1, 4 Sarkozy A....Dallapiccola B. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot. (PubMed id 14517948)1, 2 Pizzuti A....Dallapiccola B. (2003)
    6. Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. (PubMed id 9927675)1, 3 Svensson E.C....Leiden J.M. (1999)
    7. FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes. (PubMed id 15220332)1, 9 Hirai M....Hasegawa K. (2004)
    8. Increased FOG-2 in failing myocardium disrupts thyroid hormone-dependent SERCA2 gene transcription. (PubMed id 18658259)1, 9 Rouf R....Huggins G.S. (2008)
    9. Disruption of friend of GATA 2 gene (FOG-2) by a de novo t(8;10) chromosomal translocation is associated with heart defects and gonadal dysgenesis. (PubMed id 17309641)1, 9 Finelli P....Larizza L. (2007)
    10. A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription. (PubMed id 10801815)1, 9 Svensson E.C....Leiden J.M. (2000)

    External Searches for ZFPM2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing ZFPM2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23414 HGNC: 16700 AceView: ZFPM2 Ensembl:ENSG00000169946 euGenes: HUgn23414
    ECgene: ZFPM2 H-InvDB: ZFPM2

    Other Databases showing ZFPM2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZFPM2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFPM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZFPM2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ZFPM2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZFPM2 gene:
    Search GeneIP for patents involving ZFPM2

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