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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFPM2 Gene

protein-coding   GIFtS: 59
GCID: GC08P106400

Zinc Finger Protein, FOG Family Member 2

(Previous names: zinc finger protein, multitype 2)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein, FOG Family Member 21 2     hFOG-22 3
FOG22 3 5     DIH32 5
Zinc Finger Protein, Multitype 21 2     ZC2HC11B2
Friend Of GATA 22 3     Friend Of GATA22
Friend Of GATA Protein 22 3     Transcription Factor GATA4, Modulator Of2
Zinc Finger Protein 89B2 3     Zinc Finger Protein ZFPM22
FOG-22 3     Zinc Finger Protein Multitype 23
ZNF89B2 3     

External Ids:    HGNC: 167001   Entrez Gene: 234142   Ensembl: ENSG000001699467   OMIM: 6036935   UniProtKB: Q8WW383   

Export aliases for ZFPM2 gene to outside databases

Previous GC identifers: GC08P106398 GC08P105999 GC08P106287 GC08P101532


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZFPM2 Gene:
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription
factors. The family members modulate the activity of GATA family proteins, which are important regulators of
hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and
down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A
related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the
sequence. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZFPM2 Gene: 
ZFPM2 (zinc finger protein, FOG family member 2) is a protein-coding gene. Diseases associated with ZFPM2 include tricuspid atresia, and diaphragmatic hernia 3, and among its related super-pathways are Platelet activation, signaling and aggregation. GO annotations related to this gene include RNA polymerase II transcription coactivator activity and transcription factor binding. An important paralog of this gene is ZFPM1.

UniProtKB/Swiss-Prot: FOG2_HUMAN, Q8WW38
Function: Transcription regulator that plays a central role in heart morphogenesis and development of coronary
vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that
acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6.
Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter
context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a
corepressor of NR2F2 (By similarity)

Gene Wiki entry for ZFPM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFPM2 gene promoter:
         ER-alpha   NF-1   p300   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   GATA-1   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFPM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFPM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFPM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23   Ensembl cytogenetic band:  8q23.1   HGNC cytogenetic band: 8q23

ZFPM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFPM2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P106400:  view genomic region     (about GC identifiers)

Start:
106,330,920 bp from pter      End:
106,816,767 bp from pter
Size:
485,848 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FOG2_HUMAN, Q8WW38 (See protein sequence)
Recommended Name: Zinc finger protein ZFPM2  
Size: 1151 amino acids; 128159 Da
Subunit: Interacts with the N-terminal zinc-finger of GATA4, GATA5 and probably GATA6. Interacts with retinoid
nuclear receptor RXRA when ligand bound (By similarity). Interacts with corepressor CTBP2; this interaction is
however not essential for corepressor activity. Able to bind GATA1 in vitro. Interacts with NR2F2 and NR2F6 (By
similarity)
Subcellular location: Nucleus
Secondary accessions: Q32MA6 Q9NPL7 Q9NPS4 Q9UNI5
Alternative splicing: 2 isoforms:  Q8WW38-1   Q8WW38-2   (Sequence incomplete. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFPM2: NX_Q8WW38

Explore proteomics data for ZFPM2 at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylation reduces transcriptional repression activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WW38

  • ZFPM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFPM2 Protein Expression
    REFSEQ proteins: NP_036214.2  
    ENSEMBL proteins: 
     ENSP00000384179   ENSP00000430757   ENSP00000428149   ENSP00000428720   ENSP00000367733  
    Reactome Protein details: Q8WW38
    Human Recombinant Protein Products for ZFPM2: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZFPM2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--

    ZFPM2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZC2HC: Zinc fingers, C2HC-type containing
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8WW38

    ProtoNet protein and cluster: Q8WW38

    UniProtKB/Swiss-Prot: FOG2_HUMAN, Q8WW38
    Domain: The CCHC-type zinc fingers 1, 5, 6 and 8 directly bind to GATA-type zinc fingers. The Tyr residue adjacent
    to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers (By
    similarity)
    Similarity: Belongs to the FOG (Friend of GATA) family
    Similarity: Contains 3 C2H2-type zinc fingers
    Similarity: Contains 5 C2HC-type zinc fingers


    ZFPM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOG2_HUMAN, Q8WW38
    Function: Transcription regulator that plays a central role in heart morphogenesis and development of coronary
    vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that
    acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6.
    Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter
    context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a
    corepressor of NR2F2 (By similarity)

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001071nucleic acid binding transcription factor activity IEA--
    GO:0001105RNA polymerase II transcription coactivator activity NAS10438528
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity IDA10438528
         
    ZFPM2 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Zfpm2):
     cardiovascular system  cellular  endocrine/exocrine gland  homeostasis/metabolism  integument 
     liver/biliary system  mortality/aging  muscle  no phenotypic analysis  normal 
     reproductive system  respiratory system 

    ZFPM2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ZFPM2: Zfpm2tm1Sho Zfpm2tm1Jml

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFPM2 
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFPM2
    8/140 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFPM2 (see all 140):
    hsa-miR-579 hsa-miR-361-5p hsa-miR-520f hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-200b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidZFPM2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFPM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZFPM2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Platelet activation, signaling and aggregation
    Hemostasis0.43
    2MicroRNAs in cancer
    MicroRNAs in cancer
    3Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZFPM2
        Hemostasis
    Factors involved in megakaryocyte development and platelet production


    1         Kegg Pathway  (Kegg details for ZFPM2):
        MicroRNAs in cancer


    ZFPM2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFPM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/22 Interacting proteins for ZFPM2 (Q8WW383 ENSP000003841794) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GATA3P237713, ENSP000003686324I2D: score=1 STRING: ENSP00000368632
    H3F3AP842433I2D: score=1 
    H3F3BP842433I2D: score=1 
    MTA1Q133303, ENSP000003336334I2D: score=1 STRING: ENSP00000333633
    MTA2O947763, ENSP000002788234I2D: score=1 STRING: ENSP00000278823
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001570vasculogenesis IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0003148outflow tract septum morphogenesis IMP--
    GO:0003221right ventricular cardiac muscle tissue morphogenesis IMP--

    ZFPM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZFPM2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFPM2 (FOG2)

    1 Novoseek inferred chemical compound relationship for ZFPM2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 55.7 4 10801815 (1), 15507435 (1)

    Search CenterWatch for drugs/clinical trials and news about ZFPM2 / FOG2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFPM2 gene: 
    NM_012082.3  

    Unigene Cluster for ZFPM2:

    Zinc finger protein, FOG family member 2
    Hs.431009  [show with all ESTs]
    Unigene Representative Sequence: NM_012082
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407775(uc003ymd.3 uc011lhs.2) ENST00000520492 ENST00000520027
    ENST00000524235 ENST00000511341 ENST00000522160 ENST00000517361 ENST00000522296
    ENST00000378472

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    8/140 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFPM2 (see all 140):
    hsa-miR-579 hsa-miR-361-5p hsa-miR-520f hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-200b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidZFPM2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB073894.1 AF119334.1 AK296997.1 AK303058.1 AK316426.1 AL389974.1 AL389987.1 AL389988.1 
    AL389989.1 BC020928.1 BC109222.1 BC109223.1 

    5 DOTS entries:

    DT.211298  DT.95103377  DT.40208382  DT.99961666  DT.75169281 

    24/35 AceView cDNA sequences (see all 35):

    AL389974 AA442019 F12732 AL389987 BC020928 NM_012082 AL389989 AF119334 
    F10338 BM718680 BQ941160 AI269852 BX499987 AI926034 CF780708 CD511818 
    BU742351 BP336081 AL389988 AL118627 R73534 AA975109 AI370886 R49439 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZFPM2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                          -     -     -                     
    SP2:                                                            


    ECgene alternative splicing isoforms for ZFPM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFPM2 expression in normal human tissues (normalized intensities)      ZFPM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATGGATG
    ZFPM2 Expression
    About this image


    ZFPM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium
             cervix, uterine ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Pancreas (Endocrine System)    fully expand to see all 3 entries
             Islets of Langerhans
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
             pancreas ; exocrine glandular cells   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Epicardial Progenitors Cells Epicardium
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   

    See ZFPM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFPM2

    SOURCE GeneReport for Unigene cluster: Hs.431009

    UniProtKB/Swiss-Prot: FOG2_HUMAN, Q8WW38
    Tissue specificity: Widely expressed at low level

        SABiosciences Expression via Pathway-Focused PCR Array including ZFPM2: 
              Stem Cell Transcription Factors in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFPM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZFPM2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfpm21 , 5 zinc finger protein, multitype 21, 5 89.08(n)1
    93.92(a)1
      15 (15.74 cM)5
    227621  NM_011766.51  NP_035896.11 
     406550425 
    chicken
    (Gallus gallus)
    Aves ZFPM21 zinc finger protein, multitype 2 83.44(n)
    89.82(a)
      420269  XM_418380.3  XP_418380.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZFPM26
    zinc finger protein, FOG family member 2
    85(a)
    1 ↔ 1
    4(12445081-12794309)
    zebrafish
    (Danio rerio)
    Actinopterygii zfpm2a1 zinc finger protein, multitype 2a 66.43(n)
    64.2(a)
      568996  NM_001039635.1  NP_001034724.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ush6
    u-shaped
    14(a)
    1 → many
    2L(476220-540560)


    ENSEMBL Gene Tree for ZFPM2 (if available)
    TreeFam Gene Tree for ZFPM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFPM2 gene
    ZFPM12  

    ZFPM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8992 SNPs in ZFPM2 are shown (see all 8992)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219086011,2,4
    C,FTetralogy of Fallot (TOF)4 pathogenic1106708378(+) ATCAGA/GGGAAA 2 E G mis11Minor allele frequency- G:0.01EU 593
    rs283745441,2,4
    C,F,HTetralogy of Fallot (TOF)4 pathogenic1107090790(+) CCTCCA/GGTAAC 2 S G mis115Minor allele frequency- G:0.10NS NA EA WA CSA 1414
    rs1219086031,2
    Cpathogenic1107090928(+) CATACA/CTGGTC 2 M L mis10--------
    rs29574381,2
    C--101532740(+) ggcggC/Gggcgg 1 -- us2k10--------
    rs105501611,2
    C--101544479(+) tatac-/ATatata 1 -- int10--------
    rs78370691,2
    C--101544480(+) atacaC/Tatata 1 -- int12Minor allele frequency- T:0.25NA 4
    rs352344801,2
    C--101757520(+) TTCTA-/ACA/  
     CAA
    /CAT
    GTCTC
    3 -- cds10--------
    rs100962381,2
    C--101775969(+) AGAAAA/GAAAGA 1 -- int1 trp31Minor allele frequency- G:0.00WA 2
    rs1386869241,2
    C--101775981(+) GAAAG-/AAAAGA 1 -- int10--------
    rs608559251,2
    C--101831718(+) GCTCCG/CCCTCC 1 -- int11Minor allele frequency- C:0.50NA 2

    HapMap Linkage Disequilibrium report for ZFPM2 (106330920 - 106580920 bp, first 250kb of ZFPM2)

    Structural Variations
         Database of Genomic Variants (DGV) 10/35 variations for ZFPM2 (see all 35):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2357213CNV Deletion18987734
    esv2643906CNV Deletion19546169
    esv2676076CNV Deletion23128226
    esv2737392CNV Deletion23290073
    esv988675CNV Deletion20482838
    esv3206CNV Deletion18987735
    esv2318733CNV Deletion18987734
    esv2670397CNV Deletion23128226
    esv2660166CNV Deletion23128226
    esv2737394CNV Deletion23290073


    Human Gene Mutation Database (HGMD): ZFPM2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFPM2
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFPM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603693   
    OMIM disorders: 187500  610187  
    UniProtKB/Swiss-Prot: FOG2_HUMAN, Q8WW38
  • Tetralogy of Fallot (TOF) [MIM:187500]: A congenital heart anomaly which consists of pulmonary stenosis,
    ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and
    hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor)
    is pumped into the body often causing cyanosis. Note=The disease may be caused by mutations affecting the gene
    represented in this entry
  • Diaphragmatic hernia 3 (DIH3) [MIM:610187]: Form of congenital diaphragmatic hernia (CDH). CDH refers to
    a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary
    hypoplasia and pulmonary hypertension. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 19 diseases for ZFPM2:    About MalaCards
    tricuspid atresia    diaphragmatic hernia 3    diaphragmatic eventration    tetralogy of fallot
    hernia    fryns syndrome    double outlet right ventricle    ventricular septal defect
    renal dysplasia    hypoparathyroidism    gonadal dysgenesis    congenital diaphragmatic hernia
    germ cell tumors    glaucoma    hypertension    neuroblastoma
    schizophrenia    thyroiditis    endotheliitis

    4 diseases from the University of Copenhagen DISEASES database for ZFPM2:
    Congenital diaphragmatic hernia     Tetralogy of Fallot     Diaphragmatic eventration     Ventricular septal defect

    ZFPM2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for ZFPM2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 10999851 (2), 19969558 (1)

    Genetic Association Database (GAD): ZFPM2
    Human Genome Epidemiology (HuGE) Navigator: ZFPM2 (3 documents)

    Export disorders for ZFPM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFPM2 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with ZFPM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation. (PubMed id 10438528)1, 2, 3 Holmes M.... Chong B. (1999)
    2. Identification of cis- and trans-acting genetic varia nts explaining up to half the variation in circulating vascular endothelial gro wth factor levels. (PubMed id 21757650)1, 4 Debette S....Seshadri S. (2011)
    3. New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Fog2 is required for normal diaphragm and lung development in mice and humans. (PubMed id 16103912)1, 2 Ackerman K.G.... Beier D.R. (2005)
    6. ZFPM2/FOG2 and HEY2 genes analysis in nonsyndromic tricuspid atresia. (PubMed id 15643620)1, 4 Sarkozy A....Dallapiccola B. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot. (PubMed id 14517948)1, 2 Pizzuti A....Dallapiccola B. (2003)
    9. Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. (PubMed id 9927675)1, 3 Svensson E.C....Leiden J.M. (1999)
    10. FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes. (PubMed id 15220332)1, 9 Hirai M....Hasegawa K. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23414 HGNC: 16700 AceView: ZFPM2 Ensembl:ENSG00000169946 euGenes: HUgn23414
    ECgene: ZFPM2 Kegg: 23414 H-InvDB: ZFPM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFPM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZFPM2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFPM2 gene:
    Search GeneIP for patents involving ZFPM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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