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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFPM1 Gene

protein-coding   GIFtS: 55
GCID: GC16P088519

Zinc Finger Protein, FOG Family Member 1

(Previous names: zinc finger protein, multitype 1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein, FOG Family Member 11 2     ZC2HC11A2
FOG12 3 5     ZNF4082
Zinc Finger Protein, Multitype 11 2     ZNF89A2
Friend Of GATA 12 3     Friend Of GATA-12
Friend Of GATA Protein 12 3     Zinc Finger Protein ZFPM12
Zinc Finger Protein 89A2 3     ZFN89A3
FOG-12 3     Zinc Finger Protein Multitype 13
FOG2 5     

External Ids:    HGNC: 197621   Entrez Gene: 1618822   Ensembl: ENSG000001795887   OMIM: 6019505   UniProtKB: Q8IX073   

Export aliases for ZFPM1 gene to outside databases

Previous GC identifers: GC16P089491 GC16P088225 GC16P088266 GC16P087047 GC16P074246


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZFPM1 Gene: 
ZFPM1 (zinc finger protein, FOG family member 1) is a protein-coding gene. Diseases associated with ZFPM1 include dyserythropoietic anemia and thrombocytopenia, and x-linked thrombocytopenia, and among its related super-pathways are Platelet activation, signaling and aggregation and Notch signaling pathway. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and transcription factor binding. An important paralog of this gene is ZFPM2.

UniProtKB/Swiss-Prot: FOG1_HUMAN, Q8IX07
Function: Transcription regulator that plays an essential role in erythroid and megakaryocytic cell
differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of
the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity,
depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate
expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be
involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant
way with ZFPM2/FOG2 (By similarity)

Gene Wiki entry for ZFPM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010542.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFPM1 gene promoter:
         GATA-6   Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFPM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFPM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFPM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.2   Ensembl cytogenetic band:  16q24.2   HGNC cytogenetic band: 16q24.2

ZFPM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFPM1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P088519:  view genomic region     (about GC identifiers)

Start:
88,519,725 bp from pter      End:
88,603,424 bp from pter
Size:
83,700 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FOG1_HUMAN, Q8IX07 (See protein sequence)
Recommended Name: Zinc finger protein ZFPM1  
Size: 1006 amino acids; 104888 Da
Subunit: Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity (By
similarity). Interacts with the N-terminal zinc-finger of GATA1, GATA2 and probably GATA3
Subcellular location: Nucleus (By similarity)
1 PDB 3D structure from and Proteopedia for ZFPM1:
2XU7 (3D)    

Explore the universe of human proteins at neXtProt for ZFPM1: NX_Q8IX07

Explore proteomics data for ZFPM1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IX07

  • ZFPM1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFPM1 Protein Expression
    REFSEQ proteins: NP_722520.2  
    ENSEMBL proteins: 
     ENSP00000326630  
    Reactome Protein details: Q8IX07
    Human Recombinant Protein Products for ZFPM1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZFPM1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IDA15920471
    GO:0005737cytoplasm IEA--
    GO:0017053transcriptional repressor complex IDA15920471

    ZFPM1 for ontologies           About GeneDecksing



    ZFPM1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZC2HC: Zinc fingers, C2HC-type containing
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8IX07

    ProtoNet protein and cluster: Q8IX07

    UniProtKB/Swiss-Prot: FOG1_HUMAN, Q8IX07
    Domain: The CCHC-type zinc fingers 1, 5, 6 and 9 directly bind to GATA-type zinc fingers. The Tyr residue adjacent
    to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers (By
    similarity)
    Similarity: Belongs to the FOG (Friend of GATA) family
    Similarity: Contains 4 C2H2-type zinc fingers
    Similarity: Contains 5 C2HC-type zinc fingers


    ZFPM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOG1_HUMAN, Q8IX07
    Function: Transcription regulator that plays an essential role in erythroid and megakaryocytic cell
    differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of
    the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity,
    depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate
    expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be
    involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant
    way with ZFPM2/FOG2 (By similarity)

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA15920471
    GO:0001085RNA polymerase II transcription factor binding IPI11675338
    GO:0001102RNA polymerase II activating transcription factor binding IEA--
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
         
    ZFPM1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZFPM1:
     Decreased viability with pacli  Wnt reporter downregulated 

         11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Zfpm1):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     normal 

    ZFPM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ZFPM1: Zfpm1tm1Sho Zfpm1tm2Sho

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFPM1 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidZFPM1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFPM1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZFPM1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Platelet activation, signaling and aggregation
    Hemostasis0.43
    2Notch signaling pathway
    Delta-Notch Signaling Pathway0.33
    3Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class I
    4Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production
    5C-MYB transcription factor network
    C-MYB transcription factor network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for ZFPM1
        Delta-Notch Signaling Pathway
    Signaling events mediated by HDAC Class I
    C-MYB transcription factor network

    2        Reactome Pathways for ZFPM1
        Hemostasis
    Factors involved in megakaryocyte development and platelet production



    ZFPM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFPM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/28 Interacting proteins for ZFPM1 (Q8IX071, 3 ENSP000003266304) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBBP4Q090281, 3, ENSP000003625924EBI-3942619,EBI-620823 I2D: score=2 STRING: ENSP00000362592
    MTA1Q133303, ENSP000003336334I2D: score=2 STRING: ENSP00000333633
    MTA2O947763, ENSP000002788234I2D: score=2 STRING: ENSP00000278823
    MBD3O959833, ENSP000001568254I2D: score=1 STRING: ENSP00000156825
    GATA1P159763, ENSP000003658584I2D: score=4 STRING: ENSP00000365858
    About this table

    Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ----
    GO:0002295T-helper cell lineage commitment IC--
    GO:0003151outflow tract morphogenesis ISS--
    GO:0003181atrioventricular valve morphogenesis ISS--
    GO:0003192mitral valve formation ISS--

    ZFPM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZFPM1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFPM1 (FOG1)

    1 Novoseek inferred chemical compound relationship for ZFPM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 55.5 11 10329627 (3), 12483298 (1), 14530457 (1), 18299398 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about ZFPM1 / FOG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFPM1 gene: 
    NM_153813.2  

    Unigene Cluster for ZFPM1:

    Zinc finger protein, FOG family member 1
    Hs.632218  [show with all ESTs]
    Unigene Representative Sequence: AF488691
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319555(uc002fkv.3) ENST00000562417 ENST00000569086 ENST00000563351
    ENST00000562437

    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFPM1 (see all 16):
    hsa-miR-142-3p hsa-miR-520e hsa-miR-302d hsa-miR-302e hsa-miR-519a hsa-miR-520a-3p hsa-miR-372 hsa-miR-520d-3p
    SwitchGear 3'UTR luciferase reporter plasmidZFPM1 3' UTR sequence
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    Additional mRNA sequence: AF488691.1 

    4 DOTS entries:

    DT.40206410  DT.40205962  DT.75101455  DT.99990500 

    24/33 AceView cDNA sequences (see all 33):

    BE551389 AI912262 AW137251 CA394436 BX108196 AW341069 BE219988 BF512470 
    AI222436 AI299206 AI334116 BE504082 BF110624 AI221828 AI827960 AF488691 
    AI918158 BV208055 AI807104 NM_153813 AI912263 BE675939 BF432737 AI566116 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZFPM1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                          -           -                                       
    SP2:                    -     -                                                   
    SP3:                                                                              


    ECgene alternative splicing isoforms for ZFPM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFPM1 expression in normal human tissues (normalized intensities)      ZFPM1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTGCCAGC
    ZFPM1 Expression
    About this image


    ZFPM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Erythroid Progenitor Cells Definitive Yolk Sac
             mouse/organ system/cardiovascular system   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Cardiac Crescent Cells Cardiac Crescent
             heart/atrium   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             brain/midbrain   
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Fetal Inner Root Sheath Cells Inner Root Sheath
             mouse/organ system/integumental system   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See ZFPM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFPM1

    SOURCE GeneReport for Unigene cluster: Hs.632218

    UniProtKB/Swiss-Prot: FOG1_HUMAN, Q8IX07
    Tissue specificity: Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph
    node, liver and pancreas. Expressed in fetal heart, liver and spleen

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFPM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZFPM1 gene from 7/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfpm11 , 5 zinc finger protein, multitype 11, 5 78.74(n)1
    78.64(a)1
      8 (70.86 cM)5
    227611  NM_009569.31  NP_033595.11 
     1222821415 
    chicken
    (Gallus gallus)
    Aves ZFPM16
    zinc finger protein, FOG family member 1
    55(a)
    1 ↔ 1
    11(17837659-17843641)
    lizard
    (Anolis carolinensis)
    Reptilia ZFPM16
    Uncharacterized protein
    64(a)
    1 ↔ 1
    GL344425.1(2800-51828)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3981662 Friend of GATA 75.98(n)    AF241228.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zfpm11 zinc finger protein, multitype 1 55.56(n)
    52.13(a)
      407655  NM_001039460.1  NP_001034549.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ush6
    u-shaped
    12(a)
    1 → many
    2L(476220-540560)
    corn
    (Zea mays)
    Liliopsida 1460525362   -- 70.13(n)    146052536 


    ENSEMBL Gene Tree for ZFPM1 (if available)
    TreeFam Gene Tree for ZFPM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFPM1 gene
    ZFPM22  

    ZFPM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2300 SNPs in ZFPM1 are shown (see all 2300)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906242171,2
    --88518020(+) GGCCTC/GGTGGG 1 -- us2k10--------
    rs556689251,2
    C,F--88518078(+) GGGCGG/AGAGGG 1 -- us2k12Minor allele frequency- A:0.08WA NA 238
    rs118662151,2
    C,H--88518099(+) GTCCTA/TGGTTG 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1506926961,2
    C--88518143(+) CAGAGA/GGCAGC 1 -- us2k10--------
    rs1833812821,2
    --88518252(+) TTCCTA/GTCTGT 1 -- us2k10--------
    rs1143492471,2
    F--88518260(+) TGTCCA/TTGGCA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1389203911,2
    C--88518488(+) GGGAGA/GGGTCC 1 -- us2k10--------
    rs1884458001,2
    --88518519(+) CACTGA/GCGCCC 1 -- us2k10--------
    rs1494338031,2
    C--88518520(+) ACTGAC/TGCCCG 1 -- us2k10--------
    rs124455471,2
    C,F,H--88518569(+) GTGTAG/TACCGA 1 -- us2k119Minor allele frequency- T:0.39NS EA NA WA 2346

    HapMap Linkage Disequilibrium report for ZFPM1 (88519725 - 88603424 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/52 variations for ZFPM1 (see all 52):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715008CNV Deletion23290073
    esv2715019CNV Deletion23290073
    esv2715018CNV Deletion23290073
    esv2715020CNV Deletion23290073
    esv2671819CNV Deletion23128226
    dgv516e199CNV Deletion23128226
    esv2715014CNV Deletion23290073
    esv2678641CNV Deletion23128226
    esv2335139CNV Deletion18987734
    esv2715013CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601950    OMIM disorders: --

    12 diseases for ZFPM1:    About MalaCards
    dyserythropoietic anemia and thrombocytopenia    x-linked thrombocytopenia    thrombocytopenia    myelofibrosis
    thalassemia    anemia    down syndrome    parkinson's disease
    lung cancer    prostate cancer    leukemia    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ZFPM1:
    Thrombocytopenia

    ZFPM1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for ZFPM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dyserythropoietic anemia 87 1 15860665 (1)
    thrombocytopenia 1 83.4 3 14656885 (2), 12200364 (1)
    thrombocytopenia 42 1 15860665 (1)

    Genetic Association Database (GAD): ZFPM1
    Human Genome Epidemiology (HuGE) Navigator: ZFPM1 (5 documents)

    Export disorders for ZFPM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFPM1 gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with ZFPM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions. (PubMed id 12483298)1, 2, 9 Freson K....Van Geet C. (2003)
    2. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    3. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
    4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
    5. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
    6. X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. (PubMed id 12200364)1, 9 Yu C....Raskind W.H. (2002)
    7. Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis. (PubMed id 16127162)1, 9 Vannucchi A.M....Paoletti F. (2005)
    8. X-linked thrombocytopenia caused by a novel mutation of GATA-1. (PubMed id 11675338)1, 9 Mehaffey M.G.... Drachman J.G. (2001)
    9. GATA-1 forms distinct activating and repressive complexes in erythroid cells. (PubMed id 15920471)1, 9 Rodriguez P....Strouboulis J. (2005)
    10. Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction. (PubMed id 15644435)1, 9 Liew C.K....Mackay J.P. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 161882 HGNC: 19762 AceView: ZFPM1 Ensembl:ENSG00000179588 euGenes: HUgn161882
    ECgene: ZFPM1 H-InvDB: ZFPM1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFPM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFPM1 gene:
    Search GeneIP for patents involving ZFPM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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