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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFPM1 Gene

protein-coding   GIFtS: 51
GCID: GC16P088519

zinc finger protein, FOG family member 1

(Previous names: zinc finger protein, multitype 1 )
 Explore 12 diseases affiliated with
ZFPM1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZFPM1    

Aliases
for ZFPM1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc Finger Protein, FOG Family Member 11 2     Zinc Finger Protein 89A2 3
FOG11 2 3 5     FOG-12 3
FOG1 2 5     ZNF4082
ZC2HC11A1 2     Friend Of GATA-12
ZNF89A1 2     Zinc Finger Protein ZFPM12
Zinc Finger Protein, Multitype 11 2     ZFN89A3
Friend Of GATA 12 3     Zinc Finger Protein Multitype 13
Friend Of GATA Protein 12 3     

External Ids:    HGNC: 197621   Entrez Gene: 1618822   Ensembl: ENSG000001795887   OMIM: 6019505   UniProtKB: Q8IX073   

Export aliases for ZFPM1 gene to outside databases

Previous GC identifers: GC16P089491 GC16P088225 GC16P088266 GC16P087047 GC16P074246


Summaries
for ZFPM1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: FOG1_HUMAN, Q8IX07
Function: Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation.
Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1,
GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and
promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2,
ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in
gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity)

Gene Wiki entry for ZFPM1


Genomic Views
for ZFPM1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010542.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFPM1 gene promoter:
         GATA-6   Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZFPM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFPM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFPM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.2   Ensembl cytogenetic band:  16q24.2   HGNC cytogenetic band: 16q24.2

ZFPM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFPM1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P088519:  view genomic region     (about GC identifiers)

Start:
 88,519,725 bp from pter      End:
 88,601,574 bp from pter
Size:
 81,850 bases      Orientation:
 plus strand

Proteins
for ZFPM1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FOG1_HUMAN, Q8IX07 (See protein sequence)
Recommended Name: Zinc finger protein ZFPM1  
Size: 1006 amino acids; 104888 Da
Subunit: Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity (By
similarity). Interacts with the N-terminal zinc-finger of GATA1, GATA2 and probably GATA3
Subcellular location: Nucleus (By similarity)
1 PDB 3D structure from and Proteopedia for ZFPM1:
2XU7 (3D)    

Explore the universe of human proteins at neXtProt for ZFPM1: NX_Q8IX07

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IX07

    • ZFPM1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_722520.2  
    ENSEMBL proteins: 
     ENSP00000326630  
    Reactome Protein details: Q8IX07
    Human Recombinant Protein Products: 
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    Uscn Proteins for ZFPM1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IDA15920471
    GO:0005737cytoplasm IEA--
    GO:0017053transcriptional repressor complex IDA15920471


    ZFPM1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZFPM1

    Protein Domains /
    Families
    for ZFPM1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZFPM1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8IX07

    ProtoNet protein and cluster: Q8IX07

    UniProtKB/Swiss-Prot: FOG1_HUMAN, Q8IX07
    Domain: The CCHC-type zinc fingers 1, 5, 6 and 9 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to
    the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity)
    Similarity: Belongs to the FOG (Friend of GATA) family
    Similarity: Contains 4 C2H2-type zinc fingers
    Similarity: Contains 5 C2HC-type zinc fingers


    Function
    for ZFPM1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FOG1_HUMAN, Q8IX07
    Function: Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation.
    Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1,
    GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and
    promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2,
    ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in
    gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity)

    miRNA
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    hsa-miR-142-3p hsa-miR-520e hsa-miR-302d hsa-miR-302e hsa-miR-519a hsa-miR-520a-3p hsa-miR-372 hsa-miR-520d-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ZFPM1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: ZFPM1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFPM1

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA15920471
    GO:0001085RNA polymerase II transcription factor binding IPI15920471
    GO:0001102RNA polymerase II activating transcription factor binding IEA--
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--


    ZFPM1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ZFPM1:
     Decreased viability with pacli  Wnt reporter downregulated 

    Animal Models:
         Mouse knock-outs for ZFPM1: Zfpm1tm1Sho Zfpm1tm2Sho
         11 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Zfpm1):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     normal 

    ZFPM1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ZFPM1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Factors involved in megakaryocyte development and platelet production
    		Factors involved in megakaryocyte development and platelet production1.00
    2C-MYB transcription factor network
    		C-MYB transcription factor network1.00
    3Signaling events mediated by HDAC Class I
    		Signaling events mediated by HDAC Class I1.00
    4Platelet activation, signaling and aggregation
    		Hemostasis0.43
    5Notch Signaling Pathway
    		Delta-Notch Signaling Pathway0.27

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for ZFPM1 
        Delta-Notch Signaling Pathway
    Signaling events mediated by HDAC Class I
    C-MYB transcription factor network

    2        Reactome Pathways for ZFPM1
        Hemostasis
    Factors involved in megakaryocyte development and platelet production



    ZFPM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFPM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/28 Interacting proteins for ZFPM1 (Q8IX071, 3 ENSP000003266304) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBBP4Q090281, 3, ENSP000003625924EBI-3942619,EBI-620823 I2D: score=2 STRING: ENSP00000362592
    MTA1Q133303, ENSP000003336334I2D: score=2 STRING: ENSP00000333633
    MTA2O947763, ENSP000002788234I2D: score=2 STRING: ENSP00000278823
    MBD3O959833, ENSP000001568254I2D: score=1 STRING: ENSP00000156825
    GATA1P159763, ENSP000003658584I2D: score=4 STRING: ENSP00000365858
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002295T-helper cell lineage commitment IC--
    GO:0003151outflow tract morphogenesis ISS--
    GO:0003181atrioventricular valve morphogenesis ISS--
    GO:0003192mitral valve formation ISS--
    GO:0003195tricuspid valve formation ISS--


    ZFPM1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZFPM1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZFPM1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFPM1
    1 Novoseek chemical compound relationship for ZFPM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 55.5 11 10329627 (3), 12483298 (1), 14530457 (1), 18299398 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about ZFPM1 / FOG1 

    Transcripts
    for ZFPM1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZFPM1 gene: 
    NM_153813.2  

    Unigene Cluster for ZFPM1:

    Zinc finger protein, FOG family member 1
    Hs.632218  [show with all ESTs]
    Unigene Representative Sequence: AF488691
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319555(uc002fkv.3) ENST00000562417 ENST00000569086 ENST00000563351
    ENST00000562437

    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFPM1 (see all 16):
    hsa-miR-142-3p hsa-miR-520e hsa-miR-302d hsa-miR-302e hsa-miR-519a hsa-miR-520a-3p hsa-miR-372 hsa-miR-520d-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ZFPM1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFPM1 (see all 4)
    OriGene shRNA RFP: ZFPM1
    OriGene siRNA: ZFPM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFPM1
    Clone
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    Primer
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    Additional cDNA sequence: AF488691.1 

    4 DOTS entries:

    DT.40206410  DT.40205962  DT.75101455  DT.99990500 

    24/33 AceView cDNA sequences (see all 33):

    AW137251 AI222436 CA394436 BE551389 BE219988 AI299206 AI912262 BF512470 
    AW341069 BX108196 AI912263 AI807104 AI221828 AI827960 NM_153813 AF488691 
    AI918158 BE675939 BE504082 BV208055 BF110624 AI334116 BF432737 AI566116 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZFPM1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                          -           -                                       
    SP2:                    -     -                                                   
    SP3:                                                                              


    ECgene alternative splicing isoforms for ZFPM1

    Expression
    for ZFPM1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFPM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCTGCCAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZFPM1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Blood IslandsPrimitive ErythrocytesBlood
    Yolk SacDefinitive Yolk SacErythroid Progenitor CellsBlood
    PancreasDorsal Pancreatic BudImmature Beta Progenitor CellsPancreas
    PancreasVentral Pancreatic BudImmature Beta Progenitor CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZFPM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFPM1

    SOURCE GeneReport for Unigene cluster: Hs.632218

    UniProtKB/Swiss-Prot: FOG1_HUMAN, Q8IX07
    Tissue specificity: Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node,
    liver and pancreas. Expressed in fetal heart, liver and spleen

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    In Situ
    Assay Products:     
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    Orthologs
    for ZFPM1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZFPM1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ZFPM16
    		 Uncharacterized protein
    		 52(a)
    		 1 ↔ 1
    		 11(20314439-20342763)
    lizard
    (Anolis carolinensis)    		 Reptilia ZFPM16
    		 --
    		 67(a)
    		 1 ↔ 1
    		 GL344425.1(37215-51442)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3981662 Friend of GATA 75.98(n)    AF241228.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zfpm11 zinc finger protein, multitype 1 55.56(n)
    52.13(a)    		   407655  NM_001039460.1  NP_001034549.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ush6
    		 u-shaped
    		 11(a)
    		 1 → many
    		 2L(476220-540560)
    corn
    (Zea mays)    		 Liliopsida 1460525362   -- 70.13(n)    146052536 


    ENSEMBL Gene Tree for ZFPM1 (if available)
    TreeFam Gene Tree for ZFPM1 (if available) 

    Paralogs
    for ZFPM1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFPM1 gene
    ZFPM22  

    ZFPM1 for paralogs           About GeneDecksing



    Genomic Variants
    for ZFPM1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1870 NCBI SNPs in ZFPM1 are shown (see all 1870)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1906242171,2
    		--88518020(+) GGCCTC/GGTGGG 1 -- us2k10--------
    rs556689251,2
    		F,--88518078(+) GGGCGG/AGAGGG 1 -- us2k12Minor allele frequency- A:0.08WA NA 238
    rs118662151,2
    		C,H--88518099(+) GTCCTA/TGGTTG 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1506926961,2
    		--88518143(+) CAGAGA/GGCAGC 1 -- us2k10--------
    rs1833812821,2
    		--88518252(+) TTCCTA/GTCTGT 1 -- us2k10--------
    rs1143492471,2
    		F,--88518260(+) TGTCCA/TTGGCA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1389203911,2
    		--88518488(+) GGGAGA/GGGTCC 1 -- us2k10--------
    rs1884458001,2
    		--88518519(+) CACTGA/GCGCCC 1 -- us2k10--------
    rs1494338031,2
    		--88518520(+) ACTGAC/TGCCCG 1 -- us2k10--------
    rs124455471,2
    		C,F,H,--88518569(+) GTGTAG/TACCGA 1 -- us2k119Minor allele frequency- T:0.39NS EA NA WA 2346

    HapMap Linkage Disequilibrium report for ZFPM1 (88519725 - 88601574 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for ZFPM1
         7 CNVs: 30009 7137 4017 72677 10510 72679 35421
         3 Indels: 25723 72678 45485

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    Disorders / Diseases
    for ZFPM1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZFPM1 for disorders           About GeneDecksing

    OMIM gene information: 601950    OMIM disorders: --

    12 diseases for ZFPM1:    About MalaCards
    dyserythropoietic anemia    dyserythropoietic anemia with thrombocytopenia    thrombocytopenia    megakaryoblastic leukemia
    anemia    myelofibrosis    down syndrome    thalassemia
    parkinson's disease    pulmonary disease    hematopoiesis    leukemia

    3 Novoseek disease relationships for ZFPM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dyserythropoietic anemia 87 1 15860665 (1)
    thrombocytopenia 1 83.4 3 14656885 (2), 12200364 (1)
    thrombocytopenia 42 1 15860665 (1)

    Human Genome Epidemiology (HuGE) Navigator: ZFPM1 (5 documents)

    Export disorders for ZFPM1 gene to outside databases

    Publications
    for ZFPM1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFPM1 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with ZFPM1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions. (PubMed id 12483298)1, 2, 9 Freson K....Van Geet C. (2003)
    2. X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. (PubMed id 12200364)1, 9 Yu C....Raskind W.H. (2002)
    3. Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis. (PubMed id 16127162)1, 9 Vannucchi A.M....Paoletti F. (2005)
    4. X-linked thrombocytopenia caused by a novel mutation of GATA-1. (PubMed id 11675338)1, 9 Mehaffey M.G.... Drachman J.G. (2001)
    5. GATA-1 forms distinct activating and repressive complexes in erythroid cells. (PubMed id 15920471)1, 9 Rodriguez P....Strouboulis J. (2005)
    6. Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction. (PubMed id 15644435)1, 9 Liew C.K....Mackay J.P. (2005)
    7. Zinc finger protein, multitype 1, suppresses human Th 2 development via downregulation of IL-4. (PubMed id 21646796)1 Kitamura N....Kaminuma O. (2011)
    8. Insights into association of the NuRD complex with FO G-1 from the crystal structure of an RbAp48A^FOG-1 complex. (PubMed id 21047798)1 Lejon S....Mackay J.P. (2011)
    9. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)
    10. Anagrelide represses GATA-1 and FOG-1 expression with out interfering with thrombopoietin receptor signal transduction. (PubMed id 20586925)1 Ahluwalia M....Erusalimsky J.D. (2010)

    External Searches for ZFPM1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing ZFPM1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 161882 HGNC: 19762 AceView: ZFPM1 Ensembl:ENSG00000179588 euGenes: HUgn161882
    ECgene: ZFPM1 H-InvDB: ZFPM1

    Other Databases showing ZFPM1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZFPM1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFPM1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZFPM1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZFPM1 gene:
    Search GeneIP for patents involving ZFPM1

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