Aliases for ZFPM1 Gene
External Ids for ZFPM1 Gene
GeneCards Summary for ZFPM1 Gene
ZFPM1 (Zinc Finger Protein, FOG Family Member 1) is a Protein Coding gene. Diseases associated with ZFPM1 include dyserythropoietic anemia and thrombocytopenia. Among its related pathways are Hemostasis and C-MYB transcription factor network. GO annotations related to this gene include transcription factor binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription. An important paralog of this gene is ZFPM2.
UniProtKB/Swiss-Prot for ZFPM1 Gene
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).