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ZFPM1 Gene

protein-coding   GIFtS: 55
GCID: GC16P088519

Zinc Finger Protein, FOG Family Member 1

(Previous names: zinc finger protein, multitype 1)
  See ZFPM1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein, FOG Family Member 11 2     ZC2HC11A2
FOG12 3 5     ZNF4082
Zinc Finger Protein, Multitype 11 2     ZNF89A2
Friend Of GATA 12 3     Friend Of GATA-12
Friend Of GATA Protein 12 3     Zinc Finger Protein ZFPM12
Zinc Finger Protein 89A2 3     ZFN89A3
FOG-12 3     Zinc Finger Protein Multitype 13
FOG2 5     

External Ids:    HGNC: 197621   Entrez Gene: 1618822   Ensembl: ENSG000001795887   OMIM: 6019505   UniProtKB: Q8IX073   

Export aliases for ZFPM1 gene to outside databases

Previous GC identifers: GC16P089491 GC16P088225 GC16P088266 GC16P087047 GC16P074246


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZFPM1 Gene:
ZFPM1 (zinc finger protein, FOG family member 1) is a protein-coding gene. Diseases associated with ZFPM1 include dyserythropoietic anemia and thrombocytopenia, and x-linked thrombocytopenia. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and transcription factor binding. An important paralog of this gene is ZFPM2.

UniProtKB/Swiss-Prot: FOG1_HUMAN, Q8IX07
Function: Transcription regulator that plays an essential role in erythroid and megakaryocytic cell
differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of
the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity,
depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate
expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be
involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant
way with ZFPM2/FOG2 (By similarity)

Gene Wiki entry for ZFPM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFPM1 gene promoter:
         GATA-6   Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFPM1 promoter sequence
   Search Chromatin IP Primers for ZFPM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFPM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.2   Ensembl cytogenetic band:  16q24.2   HGNC cytogenetic band: 16q24.2

ZFPM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFPM1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P088519:  view genomic region     (about GC identifiers)

Start:
88,519,725 bp from pter      End:
88,603,424 bp from pter
Size:
83,700 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FOG1_HUMAN, Q8IX07 (See protein sequence)
Recommended Name: Zinc finger protein ZFPM1  
Size: 1006 amino acids; 104888 Da
Subunit: Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity (By
similarity). Interacts with the N-terminal zinc-finger of GATA1, GATA2 and probably GATA3
1 PDB 3D structure from and Proteopedia for ZFPM1:
2XU7 (3D)    

Explore the universe of human proteins at neXtProt for ZFPM1: NX_Q8IX07

Explore proteomics data for ZFPM1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZFPM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_722520.2  
    ENSEMBL proteins: 
     ENSP00000326630  
    Reactome Protein details: Q8IX07

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZC2HC: Zinc fingers, C2HC-type containing
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8IX07

    ProtoNet protein and cluster: Q8IX07

    UniProtKB/Swiss-Prot: FOG1_HUMAN, Q8IX07
    Domain: The CCHC-type zinc fingers 1, 5, 6 and 9 directly bind to GATA-type zinc fingers. The Tyr residue adjacent
    to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers (By
    similarity)
    Similarity: Belongs to the FOG (Friend of GATA) family
    Similarity: Contains 4 C2H2-type zinc fingers
    Similarity: Contains 5 C2HC-type zinc fingers


    Find genes that share domains with ZFPM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FOG1_HUMAN, Q8IX07
    Function: Transcription regulator that plays an essential role in erythroid and megakaryocytic cell
    differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of
    the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity,
    depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate
    expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be
    involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant
    way with ZFPM2/FOG2 (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA15920471
    GO:0001085RNA polymerase II transcription factor binding IPI11675338
    GO:0001102RNA polymerase II activating transcription factor binding IEA--
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with ZFPM1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZFPM1:
     Decreased viability with pacli  Wnt reporter downregulated 

         11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Zfpm1):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     normal 

    Find genes that share phenotypes with ZFPM1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ZFPM1: Zfpm1tm1Sho Zfpm1tm2Sho

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZFPM1
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    miRNA
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    hsa-miR-142-3p hsa-miR-520e hsa-miR-302d hsa-miR-302e hsa-miR-519a hsa-miR-520a-3p hsa-miR-372 hsa-miR-520d-3p
    SwitchGear 3'UTR luciferase reporter plasmidZFPM1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZFPM1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFPM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FOG1_HUMAN, Q8IX07: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IDA15920471
    GO:0005737cytoplasm IEA--
    GO:0017053transcriptional repressor complex IDA15920471

    Find genes that share ontologies with ZFPM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZFPM1 About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Notch signaling pathway (KEGG)
    Delta-Notch Signaling Pathway0.33
    3Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class I
    4Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production
    5C-MYB transcription factor network
    C-MYB transcription factor network


    Find genes that share SuperPaths with ZFPM1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for ZFPM1
        Delta-Notch Signaling Pathway
    Signaling events mediated by HDAC Class I
    C-MYB transcription factor network

    1 Reactome Pathway for ZFPM1
        Factors involved in megakaryocyte development and platelet production


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFPM1
    Interactions:

        GeneGlobe Interaction Network for ZFPM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZFPM1 (Q8IX071, 3 ENSP000003266304) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBBP4Q090281, 3, ENSP000003625924EBI-3942619,EBI-620823 I2D: score=2 STRING: ENSP00000362592
    MTA1Q133303, ENSP000003336334I2D: score=2 STRING: ENSP00000333633
    MTA2O947763, ENSP000002788234I2D: score=2 STRING: ENSP00000278823
    MBD3O959833, ENSP000001568254I2D: score=1 STRING: ENSP00000156825
    GATA1P159763, ENSP000003658584I2D: score=4 STRING: ENSP00000365858
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15920471
    GO:0002295T-helper cell lineage commitment IC--
    GO:0003151outflow tract morphogenesis ISS--
    GO:0003181atrioventricular valve morphogenesis ISS--
    GO:0003192mitral valve formation ISS--

    Find genes that share ontologies with ZFPM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFPM1 (FOG1)

    1 Novoseek inferred chemical compound relationship for ZFPM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 55.5 11 10329627 (3), 12483298 (1), 14530457 (1), 18299398 (1) (see all 7)



    Find genes that share compounds with ZFPM1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZFPM1 gene: 
    NM_153813.2  

    Unigene Cluster for ZFPM1:

    Zinc finger protein, FOG family member 1
    Hs.632218  [show with all ESTs]
    Unigene Representative Sequence: AF488691
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319555(uc002fkv.3) ENST00000562417 ENST00000569086 ENST00000563351
    ENST00000562437
    miRNA
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    hsa-miR-142-3p hsa-miR-520e hsa-miR-302d hsa-miR-302e hsa-miR-519a hsa-miR-520a-3p hsa-miR-372 hsa-miR-520d-3p
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      QuantiFast Probe-based Assays in human, mouse, rat ZFPM1

    Additional mRNA sequence: AF488691.1 

    4 DOTS entries:

    DT.40206410  DT.40205962  DT.75101455  DT.99990500 

    Selected AceView cDNA sequences (see all 33):

    BE551389 CA394436 AW341069 AW137251 BF512470 AI222436 BE219988 AI299206 
    AI912262 BX108196 BV208055 BE675939 AI827960 AI334116 AI918158 BE504082 
    BF110624 AI912263 AF488691 NM_153813 AI221828 AI807104 AI798514 AI566116 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZFPM1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                          -           -                                       
    SP2:                    -     -                                                   
    SP3:                                                                              


    ECgene alternative splicing isoforms for ZFPM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFPM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTGCCAGC
    ZFPM1 Expression
    About this image


    ZFPM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Erythroid Progenitor Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Erythroid Progenitor Cells Definitive Yolk Sac
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Primitive Erythrocytes Extraembryonic Blood Islands
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Epithelial Cells
             Fetal Inner Root Sheath Cells Inner Root Sheath
    ZFPM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFPM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632218

    UniProtKB/Swiss-Prot: FOG1_HUMAN, Q8IX07
    Tissue specificity: Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph
    node, liver and pancreas. Expressed in fetal heart, liver and spleen

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFPM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZFPM1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfpm11 , 5 zinc finger protein, multitype 11, 5 77.06(n)1
    74.77(a)1
      8 (70.86 cM)5
    227611  NM_009569.31  NP_033595.11 
     1222821415 
    chicken
    (Gallus gallus)
    Aves ZFPM11 zinc finger protein, multitype 1 69.36(n)
    62.59(a)
      415835  XM_004944290.1  XP_004944347.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZFPM16
    zinc finger protein, FOG family member 1
    63(a)
    1 ↔ 1
    GL344425.1(2800-51828)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3981662 Friend of GATA 75.98(n)    AF241228.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zfpm11 zinc finger protein, multitype 1 55.89(n)
    52.38(a)
      407655  NM_001039460.2  NP_001034549.1 
    corn
    (Zea mays)
    Liliopsida 1460525362   -- 70.13(n)    146052536 


    ENSEMBL Gene Tree for ZFPM1 (if available)
    TreeFam Gene Tree for ZFPM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZFPM1 gene
    ZFPM22  

    Find genes that share paralogs with ZFPM1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFPM1 (see all 2300)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906242171,2
    --88518020(+) GGCCTC/GGTGGG 1 -- us2k10--------
    rs556689251,2
    C,F--88518078(+) GGGCGG/AGAGGG 1 -- us2k12Minor allele frequency- A:0.08WA NA 238
    rs118662151,2
    C,H--88518099(+) GTCCTA/TGGTTG 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1506926961,2
    C--88518143(+) CAGAGA/GGCAGC 1 -- us2k10--------
    rs1833812821,2
    --88518252(+) TTCCTA/GTCTGT 1 -- us2k10--------
    rs1143492471,2
    F--88518260(+) TGTCCA/TTGGCA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1389203911,2
    C--88518488(+) GGGAGA/GGGTCC 1 -- us2k10--------
    rs1884458001,2
    --88518519(+) CACTGA/GCGCCC 1 -- us2k10--------
    rs1494338031,2
    C--88518520(+) ACTGAC/TGCCCG 1 -- us2k10--------
    rs124455471,2
    C,F,H--88518569(+) GTGTAG/TACCGA 1 -- us2k119Minor allele frequency- T:0.39NS EA NA WA 2346

    HapMap Linkage Disequilibrium report for ZFPM1 (88519725 - 88603424 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZFPM1 (see all 52):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715008CNV Deletion23290073
    esv2715019CNV Deletion23290073
    esv2715018CNV Deletion23290073
    esv2715020CNV Deletion23290073
    esv2671819CNV Deletion23128226
    dgv516e199CNV Deletion23128226
    esv2715014CNV Deletion23290073
    esv2678641CNV Deletion23128226
    esv2335139CNV Deletion18987734
    esv2715013CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFPM1
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFPM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601950    OMIM disorders: --

    2 diseases for ZFPM1:    
    About MalaCards
    dyserythropoietic anemia and thrombocytopenia    x-linked thrombocytopenia

    1 disease from the University of Copenhagen DISEASES database for ZFPM1:
    Thrombocytopenia

    Find genes that share disorders with ZFPM1           About GenesLikeMe

    3 Novoseek inferred disease relationships for ZFPM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dyserythropoietic anemia 87 1 15860665 (1)
    thrombocytopenia 1 83.4 3 14656885 (2), 12200364 (1)
    thrombocytopenia 42 1 15860665 (1)

    Genetic Association Database (GAD): ZFPM1
    Human Genome Epidemiology (HuGE) Navigator: ZFPM1 (5 documents)

    Export disorders for ZFPM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFPM1 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with ZFPM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions. (PubMed id 12483298)1, 2, 9 Freson K....Van Geet C. (Hum. Genet. 2003)
    2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    3. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    5. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    6. X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. (PubMed id 12200364)1, 9 Yu C....Raskind W.H. (Blood 2002)
    7. Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis. (PubMed id 16127162)1, 9 Vannucchi A.M....Paoletti F. (Am. J. Pathol. 2005)
    8. X-linked thrombocytopenia caused by a novel mutation of GATA-1. (PubMed id 11675338)1, 9 Mehaffey M.G.... Drachman J.G. (Blood 2001)
    9. GATA-1 forms distinct activating and repressive complexes in erythroid cells. (PubMed id 15920471)1, 9 Rodriguez P....Strouboulis J. (EMBO J. 2005)
    10. Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction. (PubMed id 15644435)1, 9 Liew C.K....Mackay J.P. (Proc. Natl. Acad. Sci. U.S.A. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 161882 HGNC: 19762 AceView: ZFPM1 Ensembl:ENSG00000179588 euGenes: HUgn161882
    ECgene: ZFPM1 H-InvDB: ZFPM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZFPM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFPM1 gene:
    Search GeneIP for patents involving ZFPM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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