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Aliases for ZFPM1 Gene

Aliases for ZFPM1 Gene

  • Zinc Finger Protein, FOG Family Member 1 2 3
  • FOG1 3 4 6
  • Zinc Finger Protein, Multitype 1 2 3
  • Friend Of GATA Protein 1 3 4
  • Zinc Finger Protein 89A 3 4
  • Friend Of GATA 1 3 4
  • FOG-1 3 4
  • FOG 3 6
  • Zinc Finger Protein Multitype 1 4
  • Zinc Finger Protein ZFPM1 3
  • Friend Of GATA-1 3
  • ZC2HC11A 3
  • ZNF408 3
  • ZNF89A 3
  • ZFN89A 4

External Ids for ZFPM1 Gene

Previous GeneCards Identifiers for ZFPM1 Gene

  • GC16P089491
  • GC16P088225
  • GC16P088266
  • GC16P087047
  • GC16P074246

Summaries for ZFPM1 Gene

GeneCards Summary for ZFPM1 Gene

ZFPM1 (Zinc Finger Protein, FOG Family Member 1) is a Protein Coding gene. Diseases associated with ZFPM1 include dyserythropoietic anemia and thrombocytopenia. Among its related pathways are Hemostasis and C-MYB transcription factor network. GO annotations related to this gene include transcription factor binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription. An important paralog of this gene is ZFPM2.

UniProtKB/Swiss-Prot for ZFPM1 Gene

  • Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).

Gene Wiki entry for ZFPM1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFPM1 Gene

Genomics for ZFPM1 Gene

Regulatory Elements for ZFPM1 Gene

Transcription factor binding sites by QIAGEN in the ZFPM1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZFPM1 Gene

Start:
88,453,317 bp from pter
End:
88,537,016 bp from pter
Size:
83,700 bases
Orientation:
Plus strand

Genomic View for ZFPM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFPM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFPM1 Gene

Proteins for ZFPM1 Gene

  • Protein details for ZFPM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX07-FOG1_HUMAN
    Recommended name:
    Zinc finger protein ZFPM1
    Protein Accession:
    Q8IX07
    Secondary Accessions:

    Protein attributes for ZFPM1 Gene

    Size:
    1006 amino acids
    Molecular mass:
    104888 Da
    Quaternary structure:
    • Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity (By similarity). Interacts with the N-terminal zinc-finger of GATA1, GATA2 and probably GATA3.

    Three dimensional structures from OCA and Proteopedia for ZFPM1 Gene

neXtProt entry for ZFPM1 Gene

Proteomics data for ZFPM1 Gene at MOPED

Post-translational modifications for ZFPM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFPM1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZFPM1 Gene

Domains for ZFPM1 Gene

Gene Families for ZFPM1 Gene

HGNC:
  • ZC2HC :Zinc fingers, C2HC-type containing
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZFPM1 Gene

Suggested Antigen Peptide Sequences for ZFPM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IX07

UniProtKB/Swiss-Prot:

FOG1_HUMAN :
  • Q8IX07
Domain:
  • The CCHC-type zinc fingers 1, 5, 6 and 9 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity).
Family:
  • Belongs to the FOG (Friend of GATA) family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
  • Contains 5 C2HC-type zinc fingers.
genes like me logo Genes that share domains with ZFPM1: view

Function for ZFPM1 Gene

Molecular function for ZFPM1 Gene

UniProtKB/Swiss-Prot Function: Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).

Gene Ontology (GO) - Molecular Function for ZFPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 15920471
GO:0001085 RNA polymerase II transcription factor binding IPI 11675338
GO:0001102 RNA polymerase II activating transcription factor binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21047798
genes like me logo Genes that share ontologies with ZFPM1: view
genes like me logo Genes that share phenotypes with ZFPM1: view

Animal Models for ZFPM1 Gene

MGI Knock Outs for ZFPM1:

Animal Model Products

CRISPR Products

miRNA for ZFPM1 Gene

miRTarBase miRNAs that target ZFPM1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZFPM1 Gene

Localization for ZFPM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFPM1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFPM1 Gene COMPARTMENTS Subcellular localization image for ZFPM1 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ZFPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IDA 15920471
GO:0005737 cytoplasm IEA --
GO:0017053 transcriptional repressor complex IDA 15920471
genes like me logo Genes that share ontologies with ZFPM1: view

Pathways for ZFPM1 Gene

genes like me logo Genes that share pathways with ZFPM1: view

Gene Ontology (GO) - Biological Process for ZFPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15920471
GO:0002295 T-helper cell lineage commitment IC 21646796
GO:0003151 outflow tract morphogenesis ISS --
GO:0003181 atrioventricular valve morphogenesis ISS --
GO:0003192 mitral valve formation ISS --
genes like me logo Genes that share ontologies with ZFPM1: view

Compounds for ZFPM1 Gene

(1) Novoseek inferred chemical compound relationships for ZFPM1 Gene

Compound -log(P) Hits PubMed IDs
zinc 55.5 9
genes like me logo Genes that share compounds with ZFPM1: view

Transcripts for ZFPM1 Gene

Unigene Clusters for ZFPM1 Gene

Zinc finger protein, FOG family member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFPM1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZFPM1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFPM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP2: - -
SP3:

Relevant External Links for ZFPM1 Gene

GeneLoc Exon Structure for
ZFPM1
ECgene alternative splicing isoforms for
ZFPM1

Expression for ZFPM1 Gene

mRNA expression in normal human tissues for ZFPM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZFPM1 Gene

This gene is overexpressed in Pancreas (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFPM1 Gene

SOURCE GeneReport for Unigene cluster for ZFPM1 Gene Hs.632218

mRNA Expression by UniProt/SwissProt for ZFPM1 Gene

Q8IX07-FOG1_HUMAN
Tissue specificity: Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.
genes like me logo Genes that share expressions with ZFPM1: view

In Situ Assay Products

Orthologs for ZFPM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFPM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFPM1 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFPM1 35
  • 82.83 (n)
  • 81 (a)
ZFPM1 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFPM1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfpm1 35
  • 77.06 (n)
  • 74.77 (a)
Zfpm1 16
Zfpm1 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFPM1 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFPM1 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfpm1 35
  • 76.17 (n)
  • 75.34 (a)
chicken
(Gallus gallus)
Aves ZFPM1 35
  • 69.36 (n)
  • 62.59 (a)
ZFPM1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFPM1 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398166 35
tropical clawed frog
(Silurana tropicalis)
Amphibia zfpm1 35
  • 58.54 (n)
  • 58.58 (a)
zebrafish
(Danio rerio)
Actinopterygii zfpm1 35
  • 55.89 (n)
  • 52.38 (a)
zfpm1 36
  • 37 (a)
OneToOne
Species with no ortholog for ZFPM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFPM1 Gene

ENSEMBL:
Gene Tree for ZFPM1 (if available)
TreeFam:
Gene Tree for ZFPM1 (if available)

Paralogs for ZFPM1 Gene

Paralogs for ZFPM1 Gene

genes like me logo Genes that share paralogs with ZFPM1: view

Variants for ZFPM1 Gene

Sequence variations from dbSNP and Humsavar for ZFPM1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs749679 -- 88,504,408(-) GGAGC(C/T)GATTT intron-variant
rs749681 -- 88,504,267(-) CACAG(A/G)ACATA intron-variant
rs868874 -- 88,503,975(+) GTGGG(C/T)ACCAG intron-variant
rs870021 -- 88,470,366(+) CATGG(A/T)CCAGG intron-variant
rs879627 -- 88,456,133(+) TCTCC(C/G)CAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFPM1 Gene

Variant ID Type Subtype PubMed ID
nsv471111 CNV Loss 18288195
nsv528456 CNV Loss 19592680
nsv907223 CNV Loss 21882294
dgv2966n71 CNV Loss 21882294
nsv907226 CNV Loss 21882294
dgv2968n71 CNV Loss 21882294
dgv2970n71 CNV Loss 21882294
dgv171n21 CNV Loss 19592680
dgv2971n71 CNV Loss 21882294
dgv921e1 CNV Complex 17122850
nsv471112 CNV Gain 18288195
nsv907251 CNV Loss 21882294
nsv907253 CNV Loss 21882294
dgv2972n71 CNV Loss 21882294
nsv907255 CNV Loss 21882294
dgv2973n71 CNV Loss 21882294
dgv2974n71 CNV Loss 21882294
nsv817747 CNV Loss 17921354
esv2715008 CNV Deletion 23290073
esv2715009 CNV Deletion 23290073
nsv103216 CNV Insertion 16902084
esv272113 CNV Insertion 20981092
dgv2975n71 CNV Loss 21882294
esv2715010 CNV Deletion 23290073
esv2335139 CNV Deletion 18987734
esv2671819 CNV Deletion 23128226
nsv907264 CNV Loss 21882294
esv2678641 CNV Deletion 23128226
dgv516e199 CNV Deletion 23128226
esv29069 CNV Loss 19812545
nsv1924 CNV Insertion 18451855
nsv1925 CNV Loss 18451855
dgv2976n71 CNV Loss 21882294
esv2715011 CNV Deletion 23290073
esv2715012 CNV Deletion 23290073
esv1139853 CNV Deletion 17803354
esv26368 CNV Gain 19812545
esv2715013 CNV Deletion 23290073
esv2715014 CNV Deletion 23290073
esv1407878 CNV Insertion 17803354
esv2715015 CNV Deletion 23290073
esv2715016 CNV Deletion 23290073
nsv907267 CNV Loss 21882294
esv2715018 CNV Deletion 23290073
esv2715019 CNV Deletion 23290073
esv33406 CNV Gain 17666407
nsv526557 CNV Loss 19592680
esv2715020 CNV Deletion 23290073
esv2715021 CNV Deletion 23290073
nsv827830 CNV Loss 20364138
esv26997 CNV Loss 19812545
nsv827832 CNV Gain 20364138

Relevant External Links for ZFPM1 Gene

HapMap Linkage Disequilibrium report
ZFPM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFPM1 Gene

Disorders for ZFPM1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZFPM1 Gene including...

Search for ZFPM1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ZFPM1 Gene

(3) Novoseek inferred disease relationships for ZFPM1 Gene

Disease -log(P) Hits PubMed IDs
dyserythropoietic anemia 87 1
thrombocytopenia 1 83.4 3
thrombocytopenia 42 1

Relevant External Links for ZFPM1

Genetic Association Database (GAD)
ZFPM1
Human Genome Epidemiology (HuGE) Navigator
ZFPM1
genes like me logo Genes that share disorders with ZFPM1: view

No data available for UniProtKB/Swiss-Prot for ZFPM1 Gene

Publications for ZFPM1 Gene

  1. Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions. (PMID: 12483298) Freson K. … Van Geet C. (Hum. Genet. 2003) 3 4 23
  2. X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. (PMID: 12200364) Yu C. … Raskind W.H. (Blood 2002) 3 23
  3. X-linked thrombocytopenia caused by a novel mutation of GATA-1. (PMID: 11675338) Mehaffey M.G. … Drachman J.G. (Blood 2001) 3 23
  4. Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis. (PMID: 16127162) Vannucchi A.M. … Paoletti F. (Am. J. Pathol. 2005) 3 23
  5. Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction. (PMID: 15644435) Liew C.K. … Mackay J.P. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 23

Products for ZFPM1 Gene

Sources for ZFPM1 Gene

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