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ZFPL1 Gene

protein-coding   GIFtS: 51
GCID: GC11P064851

Zinc Finger Protein-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein-Like 11 2
Zinc-Finger Protein In MEN1 Region1 2
Zinc Finger Protein MCG42 3
D11S7502
MCG42

External Ids:    HGNC: 128681   Entrez Gene: 75422   Ensembl: ENSG000001623007   UniProtKB: O951593   

Export aliases for ZFPL1 gene to outside databases

Previous GC identifers: GC11P067367 GC11P066533 GC11P065101 GC11P064627 GC11P064608 GC11P061179


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZFPL1 Gene:
ZFPL1 (zinc finger protein-like 1) is a protein-coding gene. Diseases associated with ZFPL1 include wermer syndrome, and multiple endocrine neoplasia.

UniProtKB/Swiss-Prot: ZFPL1_HUMAN, O95159
Function: Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the
integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFPL1 gene promoter:
         SRF   ISGF-3   p53   SRF (504 AA)   FOXO1a   Pax-4a   C/EBPalpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFPL1 promoter sequence
   Search Chromatin IP Primers for ZFPL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFPL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

ZFPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFPL1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064851:  view genomic region     (about GC identifiers)

Start:
64,851,694 bp from pter      End:
64,855,874 bp from pter
Size:
4,181 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZFPL1_HUMAN, O95159 (See protein sequence)
Recommended Name: Zinc finger protein-like 1  
Size: 310 amino acids; 34114 Da
Subunit: Interacts with GOLGA2/GM130
Sequence caution: Sequence=AAB86533.1; Type=Frameshift; Positions=110, 114, 127, 156, 157, 255;
Secondary accessions: A8K7E9 O14616 Q9UID0

Explore the universe of human proteins at neXtProt for ZFPL1: NX_O95159

Explore proteomics data for ZFPL1 at MOPED

Post-translational modifications: 

  • Phosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZFPL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006773.2  
    ENSEMBL proteins: 
     ENSP00000433673   ENSP00000435677   ENSP00000415088   ENSP00000294258   ENSP00000434454  
     ENSP00000432833   ENSP00000432529   ENSP00000437090   ENSP00000432377   ENSP00000434780  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry O95159

    ProtoNet protein and cluster: O95159

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: ZFPL1_HUMAN, O95159
    Domain: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the
    protein
    Similarity: Belongs to the ZFPL1 family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    ZFPL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFPL1_HUMAN, O95159
    Function: Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the
    integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130

         Genatlas biochemistry entry for ZFPL1:
    zinc finger protein-like 1,34kDa,expressed in exocrine pancreas

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS9653652
    GO:0005515protein binding ----
    GO:0008270zinc ion binding NAS9653652
         
    ZFPL1 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target ZFPL1:
    hsa-mir-30a-5p (MIRT028580), hsa-mir-16-5p (MIRT051227)

    Block miRNA regulation of human, mouse, rat ZFPL1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ZFPL1:
    hsa-miR-142-5p
    SwitchGear 3'UTR luciferase reporter plasmidZFPL1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFPL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZFPL1_HUMAN, O95159: Golgi apparatus, cis-Golgi network membrane; Single-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS9653652
    GO:0005794Golgi apparatus IDA--
    GO:0016021integral component of membrane IEA--

    ZFPL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFPL1
    Interactions:

        Search GeneGlobe Interaction Network for ZFPL1

    2 Interacting proteins for ZFPL1 (O951592, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5J2P561342, 3MINT-63891 I2D: score=5 
    RAD1O606713I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated NAS9653652
    GO:0016192vesicle-mediated transport IEA--

    ZFPL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFPL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZFPL1 gene: 
    NM_006782.3  

    Unigene Cluster for ZFPL1:

    Zinc finger protein-like 1
    Hs.98170  [show with all ESTs]
    Unigene Representative Sequence: AK124141
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525509 ENST00000531761 ENST00000453524 ENST00000294258(uc001ocq.1)
    ENST00000526289 ENST00000533216(uc009yqa.3 uc010rnx.2) ENST00000526440
    ENST00000526334 ENST00000526791 ENST00000526945 ENST00000532200 ENST00000530488
    ENST00000530744 ENST00000528123
    miRNA
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    Block miRNA regulation of human, mouse, rat ZFPL1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ZFPL1:
    hsa-miR-142-5p
    SwitchGear 3'UTR luciferase reporter plasmidZFPL1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZFPL1
      QuantiFast Probe-based Assays in human, mouse, rat ZFPL1

    Additional mRNA sequence: 

    AF001891.1 AF030291.1 AF043611.1 AK124141.1 AK291964.1 AK295279.1 AK308740.1 AK316044.1 
    BC012530.2 BC012814.2 

    13 DOTS entries:

    DT.85105563  DT.86858124  DT.40126158  DT.92433818  DT.101975613  DT.120753553  DT.100800316  DT.102826760 
    DT.120753558  DT.92433817  DT.95193533  DT.99940218  DT.95193509 

    Selected AceView cDNA sequences (see all 247):

    AI918306 BE904747 BQ711863 AI302554 BC012530 AW292583 BU633213 AI269455 
    AU279924 BM045142 CB141681 CA314325 AI925355 BQ920753 AI694804 CD243887 
    BI918791 CD514310 BM563334 AI419994 BP335447 BG014063 BM452367 BI823532 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZFPL1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                    -     -                 -           -     -                                                   
    SP2:                    -     -           -     -           -     -                                                   
    SP3:                    -     -                 -                                                                     
    SP4:                                            -           -     -                                                   
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for ZFPL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFPL1 expression in normal human tissues (normalized intensities)      ZFPL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGAGCTGG
    ZFPL1 Expression
    About this image


    ZFPL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ZFPL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFPL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98170

    UniProtKB/Swiss-Prot: ZFPL1_HUMAN, O95159
    Tissue specificity: Expressed strongly in the exocrine pancreas

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZFPL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfpl11 , 5 zinc finger like protein 11, 5 87.2(n)1
    92.26(a)1
      19 (4.34 cM)5
    819091  NM_024231.21  NP_077193.11 
     60764875 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia zfpl11 zinc finger protein-like 1 60.37(n)
    65.15(a)
      779657  NM_001078743.1  NP_001072211.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc637602 hypothetical protein MGC63760 75.04(n)   393646  BC058063.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG53821 , 3 CG53821 68(a)3
    56.21(n)1
    49.37(a)1
      94A83
    426181  NM_170003.21  NP_732721.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y45G12B.2a3
    Y45G12B.21
    Y45G12B.21 66(a)3
    51.92(n)1
    45.99(a)1
      V(2694601-2698407)3
    1787341  NM_071330.31  NP_503731.11 


    ENSEMBL Gene Tree for ZFPL1 (if available)
    TreeFam Gene Tree for ZFPL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFPL1 (see all 85)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1811312181,2
    --64853659(+) TCTTCC/GTACCC 1 -- int10--------
    rs1866222041,2
    --64853704(+) ACCTGC/TCTGGA 1 -- int10--------
    rs1388278951,2
    C--64853723(+) GTGGTA/TGCCAA 1 -- int10--------
    rs743273881,2
    C,F--64853749(+) AGGGAA/GCAGGA 1 -- int11Minor allele frequency- G:0.04WA 118
    rs1493759211,2
    --64853755(+) CAGGAC/TGGGGA 1 -- int10--------
    rs1471048761,2
    C--64853784(+) CACAC-/ATGTGTC 1 -- int10--------
    rs2010571261,2
    C--64853843(+) AAGTGT/CCTTCT 1 -- int11Minor allele frequency- C:0.00EU 593
    rs2018910291,2
    C--64853952(+) CTGCCA/GGCTAT 2 S G mis10--------
    rs2004515961,2
    C--64854012(+) GCCCCA/GTGGCC 2 M V mis10--------
    rs1906757251,2
    C--64854061(+) CCGGGC/TAGGAC 2 A V mis10--------

    HapMap Linkage Disequilibrium report for ZFPL1 (64851694 - 64855874 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZFPL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1174n71CNV Loss21882294
    nsv526181CNV Gain19592680

    Human Gene Mutation Database (HGMD): ZFPL1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFPL1
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFPL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    7 diseases for ZFPL1:    About MalaCards
    wermer syndrome    multiple endocrine neoplasia    tonsillitis    cerebritis
    thyroiditis    endotheliitis    prostatitis


    ZFPL1 for disorders           About GeneDecksing


    Export disorders for ZFPL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFPL1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ZFPL1)
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    1. A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. (PubMed id 9653652)1, 2, 3, 9 Hoeppener J.W.M.... Kas K. (Genomics 1998)
    2. ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport. (PubMed id 18323775)1, 2, 9 Chiu C.-F....Lowe M. (EMBO J. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PubMed id 9253601)1, 2 Guru S.C.... Chandrasekharappa S.C. (Genome Res. 1997)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    8. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7542 HGNC: 12868 AceView: ZFPL1 Ensembl:ENSG00000162300 euGenes: HUgn7542
    ECgene: ZFPL1 H-InvDB: ZFPL1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZFPL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFPL1 gene:
    Search GeneIP for patents involving ZFPL1

    GeneCards and IP:
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