ZFPL1 Gene
protein-coding GIFtS: 47
GCID: GC11P064851
|
|
zinc finger protein-like 1
| |
Aliases
for ZFPL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein-Like 11 2 | | D11S7501 2 | | MCG41 2 | | Zinc Finger Protein MCG42 3 | | Zinc-Finger Protein In MEN1 Region2 |
Export aliases for ZFPL1 gene to outside databasesPrevious GC identifers: GC11P067367 GC11P066533 GC11P065101 GC11P064627 GC11P064608 GC11P061179 |
Summaries
for ZFPL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZFPL1_HUMAN, O95159Function: Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of theintegrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130
|
Genomic Views
for ZFPL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZFPL1 gene promoter:
SRF ISGF-3 p53 SRF (504 AA) FOXO1a Pax-4a C/EBPalpha FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZFPL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFPL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13ZFPL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P064851: view genomic region
(about GC identifiers)
Start:
|
64,851,694 bp from pter |
End:
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64,855,874 bp from pter |
Size:
|
4,181 bases |
Orientation:
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plus strand |
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Proteins
for ZFPL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZFPL1_HUMAN, O95159 (See
protein sequence)Recommended Name: Zinc finger protein-like 1 Size: 310 amino acids; 34114 Da
Subunit: Interacts with GOLGA2/GM130
Subcellular location: Golgi apparatus, cis-Golgi network membrane; Single-pass membrane protein
Sequence caution: Sequence=AAB86533.1; Type=Frameshift; Positions=110, 114, 127, 156, 157, 255;
Secondary accessions: A8K7E9 O14616 Q9UID0Explore the universe of human proteins at neXtProt for ZFPL1: NX_O95159
Post-translational modifications:
Phosphorylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95159
ZFPL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006773.2
ENSEMBL proteins: ENSP00000433673 ENSP00000435677 ENSP00000415088 ENSP00000294258 ENSP00000434454 ENSP00000432833 ENSP00000432529 ENSP00000437090 ENSP00000432377 ENSP00000434780
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZFPL1 for ontologies About GeneDecksing
ZFPL1 Antibody Products:
Assay Products for ZFPL1: |
Protein
Domains /
Families
for ZFPL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZFPL1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95159ProtoNet protein and cluster: O95159 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: ZFPL1_HUMAN, O95159Domain: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the proteinSimilarity: Belongs to the ZFPL1 familySimilarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 RING-type zinc finger |
Function
for ZFPL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZFPL1_HUMAN, O95159Function: Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of theintegrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130 Genatlas biochemistry entry for ZFPL1:zinc finger protein-like 1,34kDa,expressed in exocrine pancreas
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFPL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFPL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFPL1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZFPL1 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZFPL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFPL1
2 Interacting proteins for ZFPL1 (O951592, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
NAS | 9653652 | | GO:0016192 | vesicle-mediated transport |
IEA | -- |
ZFPL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZFPL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZFPL1
Search CenterWatch for drugs/clinical trials and news about ZFPL1
|
Transcripts
for ZFPL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZFPL1 gene: NM_006782.3 Unigene Cluster for ZFPL1: Zinc finger protein-like 1 Hs.98170 [show with all ESTs]Unigene Representative Sequence: AK12414115 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000525509 ENST00000531761 ENST00000453524 ENST00000294258(uc001ocq.1)
ENST00000526289 ENST00000533216(uc009yqa.3 uc010rnx.2) ENST00000526440
ENST00000526334 ENST00000526791 ENST00000527241 ENST00000526945 ENST00000532200
ENST00000530488 ENST00000530744 ENST00000528123
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFPL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFPL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZFPL1 (NM_006782) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZFPL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFPL1 |
Additional cDNA sequence: AF001891.1 AF030291.1 AF043611.1 AK124141.1 AK291964.1 AK295279.1 AK308740.1 AK316044.1 BC012530.2 BC012814.2 13 DOTS entries: DT.85105563 DT.86858124 DT.40126158 DT.92433818 DT.101975613 DT.120753553 DT.100800316 DT.102826760 DT.120753558 DT.92433817 DT.95193533 DT.99940218 DT.95193509 24/247 AceView cDNA sequences (see all 247): BQ671091 CA416076 CD673713 BM563334 BM452367 BU526528 BM710024 BI823532 BP335447 BG014063 AI697688 BG106495 BI836741 BU624047 BU619352 AI962666 BQ575120 AI918306 AI073893 BQ431146 AI734913 CA503209 AI419994 BQ069331
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ZFPL1 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZFPL1
|
Expression
for ZFPL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZFPL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGAGCTGG
About this image
See ZFPL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZFPL1
SOURCE GeneReport for Unigene cluster: Hs.98170
UniProtKB/Swiss-Prot: ZFPL1_HUMAN, O95159Tissue specificity: Expressed strongly in the exocrine pancreas
SABiosciences Custom PCR Arrays for ZFPL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFPL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFPL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFPL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFPL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFPL1 |
Orthologs
for ZFPL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZFPL1 gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for ZFPL1 (if available)
TreeFam Gene Tree for ZFPL1 (if available) |
Paralogs
for ZFPL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZFPL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZFPL1 (64851694 - 64855874 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZFPL1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFPL1 |
|
Disorders
/ Diseases
for ZFPL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZFPL1 for disorders About GeneDecksing
2  diseases for ZFPL1: About MalaCardsmultiple endocrine neoplasia wermer syndrome
Export disorders for ZFPL1 gene to outside databases
|
Publications
for ZFPL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZFPL1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ZFPL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. (PubMed id 9653652)1, 2, 3, 9 Hoeppener J.W.M.... Kas K. (1998)
- ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport. (PubMed id 18323775)1, 2, 9 Chiu C.-F....Lowe M. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PubMed id 9253601)1, 2 Guru S.C....Chandrasekharappa S.C. (1997)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. (PubMed id 14671302)1 Clark A.G....Cargill M. (2003)
|
External Searches for ZFPL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZFPL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZFPL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZFPL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZFPL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZFPL1 gene:
Search GeneIP for patents involving ZFPL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZFPL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZFPL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFPL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFPL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFPL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFPL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFPL1 |
| |
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| |  |  |  |  | | | | |
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 | | | ZFPL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFPL1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFPL1 |
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