Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZFPL1 Gene

Aliases for ZFPL1 Gene

  • Zinc Finger Protein-Like 1 2 3
  • Zinc-Finger Protein In MEN1 Region 2 3
  • Zinc Finger Protein MCG4 3 4
  • D11S750 3
  • MCG4 3

External Ids for ZFPL1 Gene

Summaries for ZFPL1 Gene

GeneCards Summary for ZFPL1 Gene

ZFPL1 (Zinc Finger Protein-Like 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZFPL1 Gene

  • Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFPL1 Gene

Genomics for ZFPL1 Gene

Genomic Location for ZFPL1 Gene

Start:
65,084,222 bp from pter
End:
65,088,402 bp from pter
Size:
4,181 bases
Orientation:
Plus strand

Genomic View for ZFPL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFPL1 Gene

Regulatory Elements for ZFPL1 Gene

Proteins for ZFPL1 Gene

  • Protein details for ZFPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95159-ZFPL1_HUMAN
    Recommended name:
    Zinc finger protein-like 1
    Protein Accession:
    O95159
    Secondary Accessions:
    • A8K7E9
    • O14616
    • Q9UID0

    Protein attributes for ZFPL1 Gene

    Size:
    310 amino acids
    Molecular mass:
    34114 Da
    Quaternary structure:
    • Interacts with GOLGA2/GM130.
    SequenceCaution:
    • Sequence=AAB86533.1; Type=Frameshift; Positions=110, 114, 127, 156, 157, 255; Evidence={ECO:0000305};

neXtProt entry for ZFPL1 Gene

Proteomics data for ZFPL1 Gene at MOPED

Post-translational modifications for ZFPL1 Gene

No data available for DME Specific Peptides for ZFPL1 Gene

Domains for ZFPL1 Gene

Protein Domains for ZFPL1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZFPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95159

UniProtKB/Swiss-Prot:

ZFPL1_HUMAN
Domain:
  • The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein:
    • O95159
Family:
  • Belongs to the ZFPL1 family.:
    • O95159
Similarity:
  • Contains 1 B box-type zinc finger.:
    • O95159
  • Contains 1 RING-type zinc finger.:
    • O95159
genes like me logo Genes that share domains with ZFPL1: view

No data available for Gene Families for ZFPL1 Gene

Function for ZFPL1 Gene

Molecular function for ZFPL1 Gene

GENATLAS Biochemistry: zinc finger protein-like 1,34kDa,expressed in exocrine pancreas
UniProtKB/Swiss-Prot Function: Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.

Gene Ontology (GO) - Molecular Function for ZFPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 9653652
GO:0005515 protein binding --
GO:0008270 zinc ion binding NAS 9653652
genes like me logo Genes that share ontologies with ZFPL1: view

miRNA for ZFPL1 Gene

miRTarBase miRNAs that target ZFPL1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFPL1 Gene

Localization for ZFPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFPL1 Gene

Golgi apparatus, cis-Golgi network membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFPL1 Gene COMPARTMENTS Subcellular localization image for ZFPL1 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZFPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 9653652
GO:0005794 Golgi apparatus IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZFPL1: view

Pathways for ZFPL1 Gene

SuperPathways for ZFPL1 Gene

No Data Available

Interacting Proteins for ZFPL1 Gene

Gene Ontology (GO) - Biological Process for ZFPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 9653652
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ZFPL1: view

No data available for Pathways by source for ZFPL1 Gene

Transcripts for ZFPL1 Gene

Unigene Clusters for ZFPL1 Gene

Zinc finger protein-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFPL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5:
SP6: - -
SP7: -

Relevant External Links for ZFPL1 Gene

GeneLoc Exon Structure for
ZFPL1
ECgene alternative splicing isoforms for
ZFPL1

Expression for ZFPL1 Gene

mRNA expression in normal human tissues for ZFPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFPL1 Gene

SOURCE GeneReport for Unigene cluster for ZFPL1 Gene Hs.98170

mRNA Expression by UniProt/SwissProt for ZFPL1 Gene

O95159-ZFPL1_HUMAN
Tissue specificity: Expressed strongly in the exocrine pancreas.
genes like me logo Genes that share expressions with ZFPL1: view

No data available for mRNA differential expression in normal tissues for ZFPL1 Gene

Orthologs for ZFPL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFPL1 35
  • 99.25 (n)
  • 99.35 (a)
ZFPL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFPL1 35
  • 90 (n)
  • 94.52 (a)
ZFPL1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFPL1 35
  • 90.54 (n)
  • 94.19 (a)
ZFPL1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfpl1 35
  • 87.2 (n)
  • 92.26 (a)
Zfpl1 16
Zfpl1 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFPL1 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfpl1 35
  • 86.45 (n)
  • 92.58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zfpl1 35
  • 60.37 (n)
  • 65.15 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4298 35
zebrafish
(Danio rerio)
Actinopterygii zfpl1 35
  • 61.2 (n)
  • 60.2 (a)
zfpl1 36
  • 56 (a)
OneToOne
zgc63760 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000127 35
  • 54.89 (n)
  • 46.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5382 35
  • 56.21 (n)
  • 49.37 (a)
CG5382 36
  • 43 (a)
OneToOne
CG5382 37
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea Y45G12B.2 35
  • 51.92 (n)
  • 45.99 (a)
Y45G12B.2 36
  • 40 (a)
OneToOne
Y45G12B.2a 37
  • 66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9728 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8053 36
  • 37 (a)
OneToOne
Species with no ortholog for ZFPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFPL1 Gene

ENSEMBL:
Gene Tree for ZFPL1 (if available)
TreeFam:
Gene Tree for ZFPL1 (if available)

Paralogs for ZFPL1 Gene

No data available for Paralogs for ZFPL1 Gene

Variants for ZFPL1 Gene

Sequence variations from dbSNP and Humsavar for ZFPL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1802202 -- 65,086,991(+) CAGCC(G/T)AGCCC reference, missense
rs11550918 -- 65,086,494(+) TGCCC(C/T)AGCTG reference, synonymous-codon
rs35251366 - 65,087,340(+) TACGC(A/G)GGATG missense, reference
rs74327388 -- 65,086,277(+) AGGGA(A/G)CAGGA intron-variant
rs76309164 -- 65,087,423(+) TGGCC(C/T)GGCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZFPL1 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
dgv1174n71 CNV Loss 21882294

Relevant External Links for ZFPL1 Gene

HapMap Linkage Disequilibrium report
ZFPL1
Human Gene Mutation Database (HGMD)
ZFPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFPL1 Gene

Disorders for ZFPL1 Gene

No disorders were found for ZFPL1 Gene.

No data available for UniProtKB/Swiss-Prot for ZFPL1 Gene

Publications for ZFPL1 Gene

  1. A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. (PMID: 9653652) Hoeppener J.W.M. … Kas K. (Genomics 1998) 2 3 4 23
  2. ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport. (PMID: 18323775) Chiu C.-F. … Lowe M. (EMBO J. 2008) 3 4 23
  3. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PMID: 9253601) Guru S.C. … Chandrasekharappa S.C. (Genome Res. 1997) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for ZFPL1 Gene

Sources for ZFPL1 Gene

Back to Top

Content