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Aliases for ZFPL1 Gene

Aliases for ZFPL1 Gene

  • Zinc Finger Protein Like 1 2 3
  • Zinc-Finger Protein In MEN1 Region 2 3
  • Zinc Finger Protein MCG4 3 4
  • Zinc Finger Protein-Like 1 5
  • D11S750 3
  • MCG4 3

External Ids for ZFPL1 Gene

Previous GeneCards Identifiers for ZFPL1 Gene

  • GC11P067367
  • GC11P066533
  • GC11P065101
  • GC11P064627
  • GC11P064608
  • GC11P064851
  • GC11P061179

Summaries for ZFPL1 Gene

GeneCards Summary for ZFPL1 Gene

ZFPL1 (Zinc Finger Protein Like 1) is a Protein Coding gene. Diseases associated with ZFPL1 include diabetes insipidus, neurohypophyseal.

UniProtKB/Swiss-Prot for ZFPL1 Gene

  • Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFPL1 Gene

Genomics for ZFPL1 Gene

Regulatory Elements for ZFPL1 Gene

Promoters for ZFPL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZFPL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZFPL1 Gene

Chromosome:
11
Start:
65,084,222 bp from pter
End:
65,088,402 bp from pter
Size:
4,181 bases
Orientation:
Plus strand

Genomic View for ZFPL1 Gene

Genes around ZFPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFPL1 Gene

Proteins for ZFPL1 Gene

  • Protein details for ZFPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95159-ZFPL1_HUMAN
    Recommended name:
    Zinc finger protein-like 1
    Protein Accession:
    O95159
    Secondary Accessions:
    • A8K7E9
    • O14616
    • Q9UID0

    Protein attributes for ZFPL1 Gene

    Size:
    310 amino acids
    Molecular mass:
    34114 Da
    Quaternary structure:
    • Interacts with GOLGA2/GM130.
    SequenceCaution:
    • Sequence=AAB86533.1; Type=Frameshift; Positions=110, 114, 127, 156, 157, 255; Evidence={ECO:0000305};

neXtProt entry for ZFPL1 Gene

Proteomics data for ZFPL1 Gene at MOPED

Post-translational modifications for ZFPL1 Gene

Antibody Products

No data available for DME Specific Peptides for ZFPL1 Gene

Domains & Families for ZFPL1 Gene

Protein Domains for ZFPL1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZFPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95159

UniProtKB/Swiss-Prot:

ZFPL1_HUMAN :
  • The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
  • Belongs to the ZFPL1 family.
  • Contains 1 B box-type zinc finger.
Domain:
  • The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
Family:
  • Belongs to the ZFPL1 family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with ZFPL1: view

No data available for Gene Families for ZFPL1 Gene

Function for ZFPL1 Gene

Molecular function for ZFPL1 Gene

GENATLAS Biochemistry:
zinc finger protein-like 1,34kDa,expressed in exocrine pancreas
UniProtKB/Swiss-Prot Function:
Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.
genes like me logo Genes that share phenotypes with ZFPL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZFPL1

miRNA for ZFPL1 Gene

miRTarBase miRNAs that target ZFPL1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFPL1 Gene

Localization for ZFPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFPL1 Gene

Golgi apparatus, cis-Golgi network membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFPL1 Gene COMPARTMENTS Subcellular localization image for ZFPL1 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZFPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 9653652
genes like me logo Genes that share ontologies with ZFPL1: view

Pathways & Interactions for ZFPL1 Gene

SuperPathways for ZFPL1 Gene

No Data Available

Interacting Proteins for ZFPL1 Gene

Gene Ontology (GO) - Biological Process for ZFPL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZFPL1 Gene

Drugs & Compounds for ZFPL1 Gene

No Compound Related Data Available

Transcripts for ZFPL1 Gene

Unigene Clusters for ZFPL1 Gene

Zinc finger protein-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFPL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5:
SP6: - -
SP7: -

Relevant External Links for ZFPL1 Gene

GeneLoc Exon Structure for
ZFPL1
ECgene alternative splicing isoforms for
ZFPL1

Expression for ZFPL1 Gene

mRNA expression in normal human tissues for ZFPL1 Gene

Protein differential expression in normal tissues from HIPED for ZFPL1 Gene

This gene is overexpressed in Nasal epithelium (35.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFPL1 Gene



SOURCE GeneReport for Unigene cluster for ZFPL1 Gene Hs.98170

mRNA Expression by UniProt/SwissProt for ZFPL1 Gene

O95159-ZFPL1_HUMAN
Tissue specificity: Expressed strongly in the exocrine pancreas.
genes like me logo Genes that share expression patterns with ZFPL1: view

Protein tissue co-expression partners for ZFPL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZFPL1 Gene

Orthologs for ZFPL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFPL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZFPL1 35
  • 90 (n)
  • 94.52 (a)
ZFPL1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFPL1 35
  • 90.54 (n)
  • 94.19 (a)
ZFPL1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfpl1 35
  • 87.2 (n)
  • 92.26 (a)
Zfpl1 16
Zfpl1 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZFPL1 35
  • 99.25 (n)
  • 99.35 (a)
ZFPL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfpl1 35
  • 86.45 (n)
  • 92.58 (a)
oppossum
(Monodelphis domestica)
Mammalia ZFPL1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfpl1 35
  • 60.37 (n)
  • 65.15 (a)
zebrafish
(Danio rerio)
Actinopterygii zfpl1 35
  • 61.2 (n)
  • 60.2 (a)
zgc63760 35
zfpl1 36
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4298 35
fruit fly
(Drosophila melanogaster)
Insecta CG5382 37
  • 68 (a)
CG5382 35
  • 56.21 (n)
  • 49.37 (a)
CG5382 36
  • 43 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000127 35
  • 54.89 (n)
  • 46.18 (a)
worm
(Caenorhabditis elegans)
Secernentea Y45G12B.2a 37
  • 66 (a)
Y45G12B.2 35
  • 51.92 (n)
  • 45.99 (a)
Y45G12B.2 36
  • 40 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9728 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8053 36
  • 37 (a)
OneToOne
Species with no ortholog for ZFPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFPL1 Gene

ENSEMBL:
Gene Tree for ZFPL1 (if available)
TreeFam:
Gene Tree for ZFPL1 (if available)

Paralogs for ZFPL1 Gene

No data available for Paralogs for ZFPL1 Gene

Variants for ZFPL1 Gene

Sequence variations from dbSNP and Humsavar for ZFPL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs35251366 - 65,087,340(+) TACGC(A/G)GGATG reference, missense
rs1802202 -- 65,086,991(+) CAGCC(G/T)AGCCC reference, missense
rs11550918 -- 65,086,494(+) TGCCC(C/T)AGCTG reference, synonymous-codon
rs74327388 -- 65,086,277(+) AGGGA(A/G)CAGGA intron-variant
rs76309164 -- 65,087,423(+) TGGCC(C/T)GGCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZFPL1 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
dgv1174n71 CNV Loss 21882294

Variation tolerance for ZFPL1 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFPL1 Gene

HapMap Linkage Disequilibrium report
ZFPL1
Human Gene Mutation Database (HGMD)
ZFPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFPL1 Gene

Disorders for ZFPL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFPL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
diabetes insipidus, neurohypophyseal
  • neurohypophyseal diabetes insipidus
- elite association - COSMIC cancer census association via MalaCards
Search ZFPL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZFPL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFPL1
genes like me logo Genes that share disorders with ZFPL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFPL1 Gene

Publications for ZFPL1 Gene

  1. A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. (PMID: 9653652) Hoeppener J.W.M. … Kas K. (Genomics 1998) 2 3 4 23 67
  2. ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport. (PMID: 18323775) Chiu C.-F. … Lowe M. (EMBO J. 2008) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ZFPL1 Gene

Sources for ZFPL1 Gene

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