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Aliases for ZFPL1 Gene

Aliases for ZFPL1 Gene

  • Zinc Finger Protein Like 1 2 3 5
  • Zinc-Finger Protein In MEN1 Region 2 3
  • Zinc Finger Protein MCG4 3 4
  • Zinc Finger Protein-Like 1 3
  • D11S750 3
  • MCG4 3

External Ids for ZFPL1 Gene

Previous GeneCards Identifiers for ZFPL1 Gene

  • GC11P067367
  • GC11P066533
  • GC11P065101
  • GC11P064627
  • GC11P064608
  • GC11P064851
  • GC11P061179

Summaries for ZFPL1 Gene

GeneCards Summary for ZFPL1 Gene

ZFPL1 (Zinc Finger Protein Like 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZFPL1 Gene

  • Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFPL1 Gene

Genomics for ZFPL1 Gene

Regulatory Elements for ZFPL1 Gene

Enhancers for ZFPL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065414 1.4 FANTOM5 ENCODE 61.6 +340.0 339960 18.8 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 NEAT1 ZFPL1 KAT5 EIF1AD LOC105369352 POLA2 MUS81 PCNX3 FRMD8 ENSG00000255320
GH11F065470 2.1 VISTA FANTOM5 Ensembl ENCODE 44.5 +405.9 405862 40.0 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 LOC105369353 LOC105369352 KAT5 SSSCA1-AS1 NEAT1 ZFPL1 EIF1AD EHBP1L1 MRPL11 POLA2
GH11F065851 0.7 ENCODE 41.6 +773.3 773263 12.2 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 SNX32 EIF1AD ZFPL1 PCNX3 POLA2 MRPL11 FRMD8 ENSG00000258297 NEAT1 ENSG00000255320
GH11F065650 1.4 FANTOM5 Ensembl ENCODE 34.3 +569.1 569141 6.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 LOC105369352 RNASEH2C ZFPL1 KAT5 RBM14 MRPL11 LOC105369353 EIF1AD MUS81 MAP3K11
GH11F064267 0.2 ENCODE 26.7 -813.5 -813523 7.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZFPL1 TRMT112 PLCB3 POLA2 LOC102723878 FAU MRPL49 TRPT1 ENSG00000257086 C11orf84
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZFPL1 on UCSC Golden Path with GeneCards custom track

Promoters for ZFPL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109845 -22 1601 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1
ENSR00001769255 -1122 201 REST

Genomic Location for ZFPL1 Gene

Chromosome:
11
Start:
65,084,222 bp from pter
End:
65,088,402 bp from pter
Size:
4,181 bases
Orientation:
Plus strand

Genomic View for ZFPL1 Gene

Genes around ZFPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFPL1 Gene

Proteins for ZFPL1 Gene

  • Protein details for ZFPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95159-ZFPL1_HUMAN
    Recommended name:
    Zinc finger protein-like 1
    Protein Accession:
    O95159
    Secondary Accessions:
    • A8K7E9
    • O14616
    • Q9UID0

    Protein attributes for ZFPL1 Gene

    Size:
    310 amino acids
    Molecular mass:
    34114 Da
    Quaternary structure:
    • Interacts with GOLGA2/GM130.
    SequenceCaution:
    • Sequence=AAB86533.1; Type=Frameshift; Positions=110, 114, 127, 156, 157, 255; Evidence={ECO:0000305};

neXtProt entry for ZFPL1 Gene

Post-translational modifications for ZFPL1 Gene

No data available for DME Specific Peptides for ZFPL1 Gene

Domains & Families for ZFPL1 Gene

Protein Domains for ZFPL1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZFPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95159

UniProtKB/Swiss-Prot:

ZFPL1_HUMAN :
  • The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
  • Belongs to the ZFPL1 family.
  • Contains 1 B box-type zinc finger.
Domain:
  • The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
Family:
  • Belongs to the ZFPL1 family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with ZFPL1: view

No data available for Gene Families for ZFPL1 Gene

Function for ZFPL1 Gene

Molecular function for ZFPL1 Gene

GENATLAS Biochemistry:
zinc finger protein-like 1,34kDa,expressed in exocrine pancreas
UniProtKB/Swiss-Prot Function:
Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130.

Gene Ontology (GO) - Molecular Function for ZFPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 9653652
GO:0008270 zinc ion binding NAS 9653652
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFPL1: view
genes like me logo Genes that share phenotypes with ZFPL1: view

Animal Model Products

miRNA for ZFPL1 Gene

miRTarBase miRNAs that target ZFPL1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFPL1 Gene

Localization for ZFPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFPL1 Gene

Golgi apparatus, cis-Golgi network membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFPL1 Gene COMPARTMENTS Subcellular localization image for ZFPL1 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZFPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 9653652
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZFPL1: view

Pathways & Interactions for ZFPL1 Gene

SuperPathways for ZFPL1 Gene

No Data Available

Interacting Proteins for ZFPL1 Gene

Gene Ontology (GO) - Biological Process for ZFPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 9653652
GO:0006810 transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ZFPL1: view

No data available for Pathways by source and SIGNOR curated interactions for ZFPL1 Gene

Transcripts for ZFPL1 Gene

Unigene Clusters for ZFPL1 Gene

Zinc finger protein-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFPL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5:
SP6: - -
SP7: -

Relevant External Links for ZFPL1 Gene

GeneLoc Exon Structure for
ZFPL1
ECgene alternative splicing isoforms for
ZFPL1

Expression for ZFPL1 Gene

mRNA expression in normal human tissues for ZFPL1 Gene

Protein differential expression in normal tissues from HIPED for ZFPL1 Gene

This gene is overexpressed in Nasal epithelium (35.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFPL1 Gene



Protein tissue co-expression partners for ZFPL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFPL1 Gene:

ZFPL1

SOURCE GeneReport for Unigene cluster for ZFPL1 Gene:

Hs.98170

mRNA Expression by UniProt/SwissProt for ZFPL1 Gene:

O95159-ZFPL1_HUMAN
Tissue specificity: Expressed strongly in the exocrine pancreas.
genes like me logo Genes that share expression patterns with ZFPL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZFPL1 Gene

Orthologs for ZFPL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFPL1 34 35
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia ZFPL1 34 35
  • 90.54 (n)
cow
(Bos Taurus)
Mammalia ZFPL1 34 35
  • 90 (n)
mouse
(Mus musculus)
Mammalia Zfpl1 34 16 35
  • 87.2 (n)
rat
(Rattus norvegicus)
Mammalia Zfpl1 34
  • 86.45 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFPL1 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfpl1 34
  • 60.37 (n)
zebrafish
(Danio rerio)
Actinopterygii zfpl1 34 35
  • 61.2 (n)
zgc63760 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4298 34
fruit fly
(Drosophila melanogaster)
Insecta CG5382 36 34 35
  • 56.21 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000127 34
  • 54.89 (n)
worm
(Caenorhabditis elegans)
Secernentea Y45G12B.2a 36
  • 66 (a)
Y45G12B.2 34 35
  • 51.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8053 35
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9728 34
Species where no ortholog for ZFPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFPL1 Gene

ENSEMBL:
Gene Tree for ZFPL1 (if available)
TreeFam:
Gene Tree for ZFPL1 (if available)

Paralogs for ZFPL1 Gene

No data available for Paralogs for ZFPL1 Gene

Variants for ZFPL1 Gene

Sequence variations from dbSNP and Humsavar for ZFPL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111719807 -- 65,086,743(+) CCAGA(A/G)CCCGA reference, synonymous-codon
rs11227115 -- 65,082,602(+) ggact(A/G)taggc intron-variant, upstream-variant-2KB
rs112345816 -- 65,084,711(+) TTTGT(A/G)AGTGC upstream-variant-2KB, reference, missense
rs112888430 -- 65,082,353(+) TGAGG(A/T)CTGCT intron-variant, upstream-variant-2KB
rs113143197 -- 65,084,790(+) AGCCA(A/G/T)TCACG upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZFPL1 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV gain 19592680

Variation tolerance for ZFPL1 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFPL1 Gene

Human Gene Mutation Database (HGMD)
ZFPL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFPL1 Gene

Disorders for ZFPL1 Gene

Relevant External Links for ZFPL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFPL1

No disorders were found for ZFPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFPL1 Gene

Publications for ZFPL1 Gene

  1. A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. (PMID: 9653652) Hoeppener J.W.M. … Kas K. (Genomics 1998) 2 3 4 22 64
  2. ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport. (PMID: 18323775) Chiu C.-F. … Lowe M. (EMBO J. 2008) 3 4 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PMID: 9253601) Guru S.C. … Chandrasekharappa S.C. (Genome Res. 1997) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ZFPL1 Gene

Sources for ZFPL1 Gene

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