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ZFP92 Gene

protein-coding   GIFtS: 31
GCID: GC0XP152683

ZFP92 Zinc Finger Protein

(Previous names: zinc finger protein homologous to Zfp92 in mouse, zinc finger...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ZFP92 Zinc Finger Protein1 2     zfp-922
Zinc Finger Protein Homologous To Zfp92 In Mouse1 2     Zinc Finger Protein 92 Homolog2
Zinc Finger Protein 92 Homolog (Mouse)1     Zfp-923
ZNF8972     

External Ids:    HGNC: 128651   Entrez Gene: 1397352   Ensembl: ENSG000001894207   UniProtKB: A6NM283   

Export aliases for ZFP92 gene to outside databases

Previous GC identifers: GC0XU990301 GC0XP152337 GC0XP141343


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZFP92 Gene:
ZFP92 (ZFP92 zinc finger protein) is a protein-coding gene. An important paralog of this gene is ZNF707.

UniProtKB/Swiss-Prot: ZFP92_HUMAN, A6NM28
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011681.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFP92 gene promoter:
         AhR   Pax-6   POU3F2 (N-Oct-5b)   AP-4   CUTL1   HNF-4alpha1   YY1   Arnt   Pax-3   Ik-1   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFP92


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

ZFP92 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP92 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP152683:  view genomic region     (about GC identifiers)

Start:
152,683,780 bp from pter      End:
152,687,087 bp from pter
Size:
3,308 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: ZFP92_HUMAN, A6NM28 (See protein sequence)
Recommended Name: Zinc finger protein 92 homolog  
Size: 416 amino acids; 45791 Da

Explore the universe of human proteins at neXtProt for ZFP92: NX_A6NM28

Explore proteomics data for ZFP92 at MOPED


See ZFP92 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001129745.1  
ENSEMBL proteins: 
 ENSP00000462054  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry A6NM28

ProtoNet protein and cluster: A6NM28

UniProtKB/Swiss-Prot: ZFP92_HUMAN, A6NM28
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 8 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


Find genes that share domains with ZFP92           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZFP92_HUMAN, A6NM28
Function: May be involved in transcriptional regulation (By similarity)

     Genatlas biochemistry entry for ZFP92:
zinc finger protein 92 (C2H2 type,Kruppel-like)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with ZFP92           About GenesLikeMe


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZFP92_HUMAN, A6NM28: Nucleus (By similarity)

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus IEA--

Find genes that share ontologies with ZFP92           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFP92
Interactions:

    Search GeneGlobe Interaction Network for ZFP92

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--

Find genes that share ontologies with ZFP92           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for ZFP92



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZFP92 gene: 
NM_001136273.1  

Unigene Cluster for ZFP92:

ZFP92 zinc finger protein
Hs.534554  [show with all ESTs]
Unigene Representative Sequence: NM_001136273
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000338647(uc011myo.2)
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1 DOTS entry:

DT.121318152 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZFP92 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ZFP92 Expression
About this image

ZFP92 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZFP92 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.534554
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFP92 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Zfp921 , 5 zinc finger protein 921, 5 76.03(n)1
70.52(a)1
  X (37.31 cM)5
227541  NM_009566.41  NP_033592.21 
 734110965 
chicken
(Gallus gallus)
Aves --
--
(see all 6)
Uncharacterized protein
(see all 6)
38(a)
34(a)
(see all 6)
many ↔ many
many ↔ many
(see all 6)
JH375510.1(2217-6357)
AADN03018103.1(4174-6528)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZAP16
Zinc-regulated transcription factor; binds to zinc...
11(a)
1 → many
X(330431-333073) YJL056C


ENSEMBL Gene Tree for ZFP92 (if available)
TreeFam Gene Tree for ZFP92 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZFP92 gene
ZNF7072  ZNF3022  ZNF1402  ZNF8292  ZNF22  ZNF5662  
Selected SIMAP similar genes for ZFP92 using alignment to 1 protein entry:     ZFP92_HUMAN(see all similar genes):
ZNF78L1    kr-znf3    ZNF211    ZNF271    ZNF551    ZFP3
ZNF304    ZNF792    ZNF852    ZSCAN9    DKFZp547L155    ZFP41
ZNF16    ZNF256    ZNF468    ZNF55    ZNF623    ZNF70

Find genes that share paralogs with ZFP92           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZFP92 (see all 92)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1836731361,2
--152681812(+) CTCTCA/TAGTCT 1 -- us2k10--------
rs1884271941,2
--152681813(+) TCTCAA/CGTCTT 1 -- us2k10--------
rs1917097921,2
--152682010(+) TGTGGC/TGTTGT 1 -- us2k10--------
rs1849681791,2
--152682011(+) GTGGCA/GTTGTT 1 -- us2k10--------
rs1902079081,2
--152682060(+) AAAAGC/GTTGGA 1 -- us2k10--------
rs1498270771,2
C--152682097(+) GAGAAC/GCAGAG 1 -- us2k10--------
rs1815034711,2
--152682165(+) CTGTCC/GTAGTC 1 -- us2k10--------
rs1457944301,2
--152682171(+) TAGTCC/TTCCTG 1 -- us2k10--------
rs1869840151,2
--152682225(+) GAAAAG/TGTTGC 1 -- us2k10--------
rs59871091,2
C--152682290(+) tgagaA/Gcctca 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ZFP92 (152683780 - 152687087 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for ZFP92:    About this table    
Variant IDTypeSubtypePubMed ID
esv33199CNV Gain+Loss17666407

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with ZFP92           About GenesLikeMe

Genetic Association Database (GAD): ZFP92

Export disorders for ZFP92 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZFP92 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZFP92)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
  2. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
  3. Comparative genome sequence analysis of the Bpa/Str region in mouse and man. (PubMed id 10854409)1 Mallon A.-M....Brown S.D.M. (Genome Res. 2000)
  4. Expressed STSs and transcription of human Xq28. (PubMed id 9099879)1 Esposito T.... D'Esposito M. (Gene 1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 139735 HGNC: 12865 Ensembl:ENSG00000189420 euGenes: HUgn139735 ECgene: ZFP92
H-InvDB: ZFP92

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZFP92 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZFP92 gene:
Search GeneIP for patents involving ZFP92

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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 Search Addgene for plasmids for ZFP92
  Search eBioscience for proteins for ZFP92
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  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for ZFP92
 antibodies-online antibodies for ZFP92 (6 products)
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 antibodies-online peptides for ZFP92
 antibodies-online proteins for ZFP92
       
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