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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFP91-CNTF Gene

protein-coding   GIFtS: 27
GCID: GC11P058346

ZFP91-CNTF Readthrough (NMD Candidate)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ZFP91-CNTF Readthrough (NMD Candidate)1 2

External Ids:    HGNC: 334411   Entrez Gene: 3866072   Ensembl: ENSG000002550737   UniProtKB: H3BTR04   
ORGUL members:         
NONCODE14:n406578      

Export aliases for ZFP91-CNTF gene to outside databases

Previous GC identifers: GC11U900395 GC11P058123 GC11P058103


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZFP91-CNTF Gene:
This gene represents a read-through transcript composed of ZFP91 and CNTF sequence. This transcript is thought to
be non-coding because it would be subject to nonsense-mediated mRNA decay (NMD). Read-through transcription of
ZFP91 and CNTF has also been observed in mouse. (provided by RefSeq, Aug 2008)

GeneCards Summary for ZFP91-CNTF Gene: 
ZFP91-CNTF (ZFP91-CNTF readthrough (NMD candidate)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with ZFP91-CNTF include melanoma, and leukemia. An important paralog of this gene is ZNF692.

Gene Wiki entry for ZFP91-CNTF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZFP91-CNTF
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFP91-CNTF promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFP91-CNTF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP91-CNTF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

ZFP91-CNTF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP91-CNTF gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P058346:  view genomic region     (about GC identifiers)

Start:
58,346,587 bp from pter      End:
58,393,206 bp from pter
Size:
46,620 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/TrEMBL: H3BTR0 (See protein sequence)
Recommended Name: Protein ZFP91-CNTF  
Size: 354 amino acids; 40605 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

ZFP91-CNTF Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

ENSEMBL proteins: 
 ENSP00000455911   ENSP00000457288  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry H3BTR0

ProtoNet protein and cluster: H3BTR0


ZFP91-CNTF for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0008270zinc ion binding ----
GO:0046872metal ion binding ----
     
ZFP91-CNTF for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFP91-CNTF

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for ZFP91-CNTF

Search CenterWatch for drugs/clinical trials and news about ZFP91-CNTF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZFP91-CNTF gene: 
NM_170768.2  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000389919(uc010rkm.2) ENST00000422974
miRNA
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24/493 AceView cDNA sequences (see all 493):

BM851264 BQ014616 BX095716 AL045405 AA075977 AI521486 BF516085 BI868768 
D31537 BX383320 AA765904 BQ188322 BX415938 AI684356 CA336703 CD654231 
CR600105 AW003047 AA278899 AW275235 CA848275 NM_170768 BF058569 AI380912 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZFP91-CNTF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ZFP91-CNTF Expression
About this image


Genevestigator expression for ZFP91-CNTF
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZFP91-CNTF gene from 5/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia U053425 sequence U05342   --   19 (8.73 cM) 12763528 
chicken
(Gallus gallus)
Aves ZFP916
Uncharacterized protein
75(a)
1 → many
5(16223259-16237931)
lizard
(Anolis carolinensis)
Reptilia --
--
67(a)
1 → many
1(91283282-91298305)
zebrafish
(Danio rerio)
Actinopterygii ZFP916
ZFP91 zinc finger protein
30(a)
1 → many
1(40509087-40532942)
fruit fly
(Drosophila melanogaster)
Insecta CG153366
--
19(a)
possible ortholog
X(8041982-8042529)


ENSEMBL Gene Tree for ZFP91-CNTF (if available)
TreeFam Gene Tree for ZFP91-CNTF (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ZFP91-CNTF gene
ZNF6922  ZNF6532  ZFP912  ENSG000002674772  ZNF2762  
18/36 SIMAP similar genes for ZFP91-CNTF using alignment to 1 protein entry:     H3BTR0_HUMAN(see all similar genes):
ZFP91    ZNF55    ZNF692    A-328A3.4    DKFZp434J0650    ZFS-5
ZNF56    ZNFN1A2    kr-znf3    DKFZp686M04222    ZNF345    ZFP64
ZNF770    ZNF78L1    DKFZp666C237    HZF40    ZFS-2    ZNF

ZFP91-CNTF for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ZFP91-CNTF:    About this table     
Variant IDTypeSubtypePubMed ID
esv268766CNV Insertion20981092
nsv528190CNV Loss19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for ZFP91-CNTF:    About MalaCards
melanoma    leukemia


ZFP91-CNTF for disorders           About GeneDecksing


Export disorders for ZFP91-CNTF gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ZFP91-CNTF gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ZFP91-CNTF)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. (PubMed id 12738986)1, 3 Unoki M.... Nakamura Y. (2003)
  2. Susceptibility loci associated with specific and share d subtypes of lymphoid malignancies. (PubMed id 23349640)1 Vijai J....Offit K. (2013)
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
  6. Single-Nucleotide Polymorphisms in NAGNAG Acceptors Are Highly Predictive for Variations of Alternative Splicing. (PubMed id 16400609)1 Hiller M.... Platzer M. (2006)
  7. Identification of novel ARF binding proteins by two-hybrid screening. (PubMed id 16582619)1 Tompkins V.... Quelle D.E. (2006)
  8. Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. (PubMed id 15009096)1 Obuse C....Yoda K. (2004)
  9. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A....Gygi S.P. (2004)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 386607 HGNC: 33441 AceView: CNTF Ensembl:ENSG00000255073 euGenes: HUgn386607
ECgene: ZFP91-CNTF H-InvDB: ZFP91-CNTF

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ZFP91-CNTF Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ZFP91-CNTF gene:
Search GeneIP for patents involving ZFP91-CNTF

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFP91-CNTF
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZFP91-CNTF
Customized:
 lentivirus for stable overexpression of ZFP91-CNTF
 lentivirus expression plasmids for stable overexpression of ZFP91-CNTF
 adenovirus for overexpression of ZFP91-CNTF
 Search LSBio for Antibodies for ZFP91-CNTF
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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