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Aliases for ZFP91 Gene

Aliases for ZFP91 Gene

  • ZFP91 Zinc Finger Protein 2 3
  • Zinc Finger Protein Homologous To Zfp91 In Mouse 2 3
  • Zinc Finger Protein 91 Homolog 3 4
  • Zinc Finger Protein 757 3 4
  • ZFP-91 3 4
  • ZNF757 3 4
  • Drug Resistance-Associated Sequence In Melanoma 8 3
  • Zinc Finger Protein 91 Homolog (Mouse) 2
  • E3 Ubiquitin-Protein Ligase ZFP91 3
  • Penta Zinc Finger Protein 3
  • EC 6.3.2.- 4
  • FKSG11 3
  • DMS-8 3
  • DSM-8 3
  • PZF 3

External Ids for ZFP91 Gene

Previous GeneCards Identifiers for ZFP91 Gene

  • GC11P060740
  • GC11P059860
  • GC11P058597
  • GC11P058122
  • GC11P058104
  • GC11P058347
  • GC11P054694

Summaries for ZFP91 Gene

Entrez Gene Summary for ZFP91 Gene

  • The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]

GeneCards Summary for ZFP91 Gene

ZFP91 (ZFP91 Zinc Finger Protein) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity and nucleic acid binding. An important paralog of this gene is ZNF276.

UniProtKB/Swiss-Prot for ZFP91 Gene

  • Atypical E3 ubiquitin-protein ligase that mediates Lys-63-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.

Gene Wiki entry for ZFP91 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP91 Gene

Genomics for ZFP91 Gene

Regulatory Elements for ZFP91 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZFP91 Gene

Start:
58,579,111 bp from pter
End:
58,621,550 bp from pter
Size:
42,440 bases
Orientation:
Plus strand

Genomic View for ZFP91 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFP91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP91 Gene

Proteins for ZFP91 Gene

  • Protein details for ZFP91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JP5-ZFP91_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase ZFP91
    Protein Accession:
    Q96JP5
    Secondary Accessions:
    • A6NHC4
    • A8MSG7
    • Q86V47
    • Q96JP4
    • Q96QA3

    Protein attributes for ZFP91 Gene

    Size:
    570 amino acids
    Molecular mass:
    63445 Da
    Quaternary structure:
    • Interacts with MAP3K14/NIK.
    Miscellaneous:
    • In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or HECT domain) known to mediate E3 ligase activity
    SequenceCaution:
    • Sequence=AAL09963.1; Type=Frameshift; Positions=72, 80; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZFP91 Gene

    Alternative splice isoforms for ZFP91 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP91 Gene

Proteomics data for ZFP91 Gene at MOPED

Post-translational modifications for ZFP91 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP91 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZFP91 Gene

Domains for ZFP91 Gene

Gene Families for ZFP91 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZFP91 Gene

Suggested Antigen Peptide Sequences for ZFP91 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JP5

UniProtKB/Swiss-Prot:

ZFP91_HUMAN :
  • Q96JP5
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFP91: view

Function for ZFP91 Gene

Molecular function for ZFP91 Gene

UniProtKB/Swiss-Prot Function:
Atypical E3 ubiquitin-protein ligase that mediates Lys-63-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.

Enzyme Numbers (IUBMB) for ZFP91 Gene

Gene Ontology (GO) - Molecular Function for ZFP91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 20682767
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP91: view

Phenotypes for ZFP91 Gene

GenomeRNAi human phenotypes for ZFP91:
genes like me logo Genes that share phenotypes with ZFP91: view

Animal Model Products

miRNA for ZFP91 Gene

miRTarBase miRNAs that target ZFP91

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFP91

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFP91 Gene

Localization for ZFP91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP91 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP91 Gene COMPARTMENTS Subcellular localization image for ZFP91 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZFP91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP91: view

Pathways for ZFP91 Gene

SuperPathways for ZFP91 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
    • Obesity in human,mouse,rat

UniProtKB/Swiss-Prot Q96JP5-ZFP91_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ZFP91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007250 activation of NF-kappaB-inducing kinase activity IDA 20682767
GO:0070534 protein K63-linked ubiquitination IDA 20682767
genes like me logo Genes that share ontologies with ZFP91: view

No data available for Pathways by source for ZFP91 Gene

Transcripts for ZFP91 Gene

mRNA/cDNA for ZFP91 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFP91

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP91 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
SP1: - - - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for ZFP91 Gene

GeneLoc Exon Structure for
ZFP91
ECgene alternative splicing isoforms for
ZFP91

Expression for ZFP91 Gene

mRNA expression in normal human tissues for ZFP91 Gene

Protein differential expression in normal tissues for ZFP91 Gene

This gene is overexpressed in Adrenal (20.4), Lung (11.8), and Testis (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFP91 Gene

mRNA Expression by UniProt/SwissProt for ZFP91 Gene

Q96JP5-ZFP91_HUMAN
Tissue specificity: Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific
genes like me logo Genes that share expressions with ZFP91: view

Expression partners for ZFP91 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZFP91 Gene

Orthologs for ZFP91 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFP91 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZFP91 35
  • 84.63 (n)
  • 87.59 (a)
-- 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZFP91 35
  • 91.74 (n)
  • 93.85 (a)
-- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp91 35
  • 90.02 (n)
  • 91.2 (a)
Zfp91 16
Zfp91 36
  • 92 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZFP91 35
  • 98.35 (n)
  • 98.41 (a)
ZFP91 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp91 35
  • 89.54 (n)
  • 90.65 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZFP91 35
  • 74.35 (n)
  • 78.91 (a)
ZFP91 36
  • 89 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 75 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4542 35
zfp91 35
  • 68.15 (n)
  • 72.7 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24472 35
zebrafish
(Danio rerio)
Actinopterygii ZFP91 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 13 (a)
OneToMany
Species with no ortholog for ZFP91:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFP91 Gene

ENSEMBL:
Gene Tree for ZFP91 (if available)
TreeFam:
Gene Tree for ZFP91 (if available)

Paralogs for ZFP91 Gene

Paralogs for ZFP91 Gene

Selected SIMAP similar genes for ZFP91 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZFP91 Gene

genes like me logo Genes that share paralogs with ZFP91: view

Variants for ZFP91 Gene

Sequence variations from dbSNP and Humsavar for ZFP91 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_021889 -
VAR_032454 -

Structural Variations from Database of Genomic Variants (DGV) for ZFP91 Gene

Variant ID Type Subtype PubMed ID
nsv528190 CNV Loss 19592680
esv268766 CNV Insertion 20981092

Relevant External Links for ZFP91 Gene

HapMap Linkage Disequilibrium report
ZFP91

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP91 Gene

Disorders for ZFP91 Gene

Relevant External Links for ZFP91

Genetic Association Database (GAD)
ZFP91
Human Genome Epidemiology (HuGE) Navigator
ZFP91

No disorders were found for ZFP91 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZFP91 Gene

Publications for ZFP91 Gene

  1. Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. (PMID: 12738986) Unoki M. … Nakamura Y. (Int. J. Oncol. 2003) 2 3 4
  2. An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. (PMID: 20682767) Jin X. … Lee J.J. (J. Biol. Chem. 2010) 2 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. (PMID: 15576338) Rosas-Acosta G. … Wilson V.G. (Mol. Cell Proteomics 2005) 3

Products for ZFP91 Gene

Sources for ZFP91 Gene

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