Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFP91 Gene

protein-coding   GIFtS: 44
GCID: GC11P058347

ZFP91 Zinc Finger Protein

(Previous names: zinc finger protein homologous to Zfp91 in mouse, zinc finger...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ZFP91 Zinc Finger Protein1 2     PZF2
Zinc Finger Protein Homologous To Zfp91 In Mouse1 2     ZFP-912
Zinc Finger Protein 7572 3     Drug Resistance-Associated Sequence In Melanoma 82
Zinc Finger Protein 91 Homolog2 3     E3 Ubiquitin-Protein Ligase ZFP912
ZNF7572 3     Penta Zinc Finger Protein2
Zinc Finger Protein 91 Homolog (Mouse)1     EC 6.3.2.-3
DMS-82     Zfp-913
DSM-82     

External Ids:    HGNC: 149831   Entrez Gene: 808292   Ensembl: ENSG000001866607   UniProtKB: Q96JP53   
ORGUL members:         
NONCODE14:n406578      

Export aliases for ZFP91 gene to outside databases

Previous GC identifers: GC11P060740 GC11P059860 GC11P058597 GC11P058122 GC11P058104 GC11P054694


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZFP91 Gene:
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains
C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins.
This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor
signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant
composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding.
Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also
been identified on chromosome 2. (provided by RefSeq, Oct 2010)

GeneCards Summary for ZFP91 Gene: 
ZFP91 (ZFP91 zinc finger protein) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with ZFP91 include melanoma, and obesity. GO annotations related to this gene include ubiquitin-protein ligase activity and nucleic acid binding. An important paralog of this gene is ZNF692.

UniProtKB/Swiss-Prot: ZFP91_HUMAN, Q96JP5
Function: Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK,
leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical
NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis

Gene Wiki entry for ZFP91 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFP91 gene promoter:
         C/EBPbeta   Sp1   HOXA3   C/EBPalpha   c-Ets-1   AREB6   FOXC1   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZFP91

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP91


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12

ZFP91 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP91 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P058347:  view genomic region     (about GC identifiers)

Start:
58,346,584 bp from pter      End:
58,389,023 bp from pter
Size:
42,440 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZFP91_HUMAN, Q96JP5 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase ZFP91  
Size: 570 amino acids; 63445 Da
Subunit: Interacts with MAP3K14/NIK
Subcellular location: Nucleus
Miscellaneous: In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc
finger or HECT domain) known to mediate E3 ligase activity
Sequence caution: Sequence=AAL09963.1; Type=Frameshift; Positions=72, 80;
Secondary accessions: A6NHC4 A8MSG7 Q86V47 Q96JP4 Q96QA3
Alternative splicing: 2 isoforms:  Q96JP5-1   Q96JP5-2   

Explore the universe of human proteins at neXtProt for ZFP91: NX_Q96JP5

Explore proteomics data for ZFP91 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96JP5

  • ZFP91 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFP91 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001183980.1  NP_444251.1  

    ENSEMBL proteins: 
     ENSP00000339030  

    Human Recombinant Protein Products for ZFP91: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ZFP91
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ZFP91
    GenScript Custom Purified and Recombinant Proteins Services for ZFP91
    Novus Biologicals ZFP91 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZFP91 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    ZFP91 for ontologies           About GeneDecksing



    ZFP91 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZFP91
    GenScript Custom Superior Antibodies Services for ZFP91
    Novus Biologicals ZFP91 Antibodies
    Abcam antibodies for ZFP91
    Cloud-Clone Corp. Antibodies for ZFP91 
    Search ThermoFisher Antibodies for ZFP91
    LSBio Antibodies in human, mouse, rat for ZFP91 

    Assay Products for ZFP91: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZFP91
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZFP91
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZFP91 
    Cloud-Clone Corp. CLIAs for ZFP91


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96JP5

    ProtoNet protein and cluster: Q96JP5

    UniProtKB/Swiss-Prot: ZFP91_HUMAN, Q96JP5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    ZFP91 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFP91_HUMAN, Q96JP5
    Function: Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK,
    leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical
    NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZFP91 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZFP91:
     Decreased viability with pacli  Increased cell number in G1, a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFP91 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZFP91

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZFP91 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZFP91 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFP91
    8/123 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFP91 (see all 123):
    hsa-miR-549 hsa-miR-323-3p hsa-miR-520e hsa-miR-607 hsa-miR-520f hsa-miR-3194-5p hsa-miR-640 hsa-miR-188-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZFP91
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFP91

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZFP91
    Sirion Biotech Customized adenovirus for overexpression of ZFP91

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ZFP91 (see all 9)
    OriGene ORF clones in mouse, rat for ZFP91
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZFP91 (NM_001197051)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFP91
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP91
    Sirion Biotech Customized lentivirus for stable overexpression of ZFP91 
                         Customized lentivirus expression plasmids for stable overexpression of ZFP91 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZFP91
    Search LifeMap BioReagents cell lines for ZFP91
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP91


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: ZFP91_HUMAN, Q96JP5
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFP91

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/12 Interacting proteins for ZFP91 (Q96JP53 ENSP000003390304) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    CENPAP494503, ENSP000003368684I2D: score=1 STRING: ENSP00000336868
    RNPS1Q152873, ENSP000003158594I2D: score=1 STRING: ENSP00000315859
    PACSIN1Q9BY113I2D: score=2 
    FOSP011003I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007250activation of NF-kappaB-inducing kinase activity IDA--
    GO:0070534protein K63-linked ubiquitination IDA--

    ZFP91 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFP91

    Search CenterWatch for drugs/clinical trials and news about ZFP91

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFP91 gene (2 alternative transcripts): 
    NM_001197051.1  NM_053023.4  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000316059(uc001nmx.4 uc001nmy.4)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFP91
    8/123 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFP91 (see all 123):
    hsa-miR-549 hsa-miR-323-3p hsa-miR-520e hsa-miR-607 hsa-miR-520f hsa-miR-3194-5p hsa-miR-640 hsa-miR-188-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZFP91
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFP91
    Clone
    Products:
         
    OriGene clones in human, mouse for ZFP91 (see all 9)
    OriGene ORF clones in mouse, rat for ZFP91
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZFP91 (NM_001197051)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFP91
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP91
    Sirion Biotech Customized lentivirus for stable overexpression of ZFP91 
                         Customized lentivirus expression plasmids for stable overexpression of ZFP91 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZFP91
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFP91
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFP91
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP91

    24/493 AceView cDNA sequences (see all 493):

    BQ716412 AI589131 NM_000614 BF940716 BF058569 BP350072 BX383320 AI493873 
    AW275211 BM667429 AI742847 AA075977 CA425830 BQ015036 CK299809 BX095716 
    BC074963 N62831 AI186641 D45634 BM697827 CD516544 CD654231 AI076789 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZFP91    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
    SP1:              -                                               -     -     -                     
    SP2:              -                                                                                 
    SP3:              -                                                                                 
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for ZFP91

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFP91 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZFP91 Expression
    About this image


    See ZFP91 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFP91

    UniProtKB/Swiss-Prot: ZFP91_HUMAN, Q96JP5
    Tissue specificity: Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific

        SABiosciences Expression via Pathway-Focused PCR Arrays including ZFP91: 
              Growth Factors in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZFP91
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFP91
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFP91
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP91
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP91

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZFP91 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp911 , 5 zinc finger protein 911, 5 90.85(n)1
    92.61(a)1
      19 (8.73 cM)5
    1099101  NM_053009.31  NP_443735.21 
     127636605 
    chicken
    (Gallus gallus)
    Aves ZFP911 zinc finger protein 91 homolog (mouse) 74.88(n)
    78.8(a)
      423128  XM_001231963.2  XP_001231964.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    74(a)
    1 → many
    1(91283282-91298305)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.244722 Xenopus laevis transcribed sequence with strong similarity more 79.15(n)    CB199311.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-113e8.101 si:ch211-113e8.10 60.65(n)
    62.1(a)
      555616  XM_678183.5  XP_683275.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG153366
    --
    19(a)
    possible ortholog
    X(8041982-8042529)


    ENSEMBL Gene Tree for ZFP91 (if available)
    TreeFam Gene Tree for ZFP91 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFP91 gene
    ZNF6922  ZNF6532  ENSG000002674772  ZFP91-CNTF2  ZNF2762  
    4 SIMAP similar genes for ZFP91 using alignment to 2 protein entries:     ZFP91_HUMAN (see all proteins):
    ZFP91-CNTF    ZNF702P    ZNF323    ZNF692

    ZFP91 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZFP91
    PGOHUM00000240283


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in ZFP91 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0324544
    ----see VAR_0324542 V I mis40--------
    VAR_0218894
    ----see VAR_0218892 S G mis40--------

    HapMap Linkage Disequilibrium report for ZFP91 (58346584 - 58389023 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZFP91:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv268766CNV Insertion20981092
    nsv528190CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFP91
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFP91

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for ZFP91:    About MalaCards
    melanoma    obesity    leukemia


    ZFP91 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZFP91
    Human Genome Epidemiology (HuGE) Navigator: ZFP91 (1 document)

    Export disorders for ZFP91 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFP91 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with ZFP91)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. (PubMed id 20682767)1, 2, 3 Jin X.... Lee J.J. (2010)
    2. Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. (PubMed id 12738986)1, 2, 3 Unoki M.... Nakamura Y. (2003)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Susceptibility loci associated with specific and share d subtypes of lymphoid malignancies. (PubMed id 23349640)1 Vijai J....Offit K. (2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80829 HGNC: 14983 AceView: CNTF Ensembl:ENSG00000186660 euGenes: HUgn80829
    ECgene: ZFP91 H-InvDB: ZFP91

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFP91 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFP91 gene:
    Search GeneIP for patents involving ZFP91

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZFP91  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ZFP91  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZFP91  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZFP91   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZFP91   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZFP91   OriGene Custom Protein Services for ZFP91  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZFP91
     QIAGEN SeqTarget long-range PCR primers for resequencing ZFP91
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP91
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFP91
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP91
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFP91
     GenScript Custom Purified and Recombinant Proteins Services for ZFP91 GenScript cDNA clones with any tag delivered in your preferred vector for ZFP91
     GenScript Custom Assay Services for ZFP91 GenScript Custom Superior Antibodies Services for ZFP91
     GenScript Custom overexpressing Cell Line Services for ZFP91 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ZFP91 promoter
     Search Chromatin IP Primers for ZFP91
     RT2 qPCR Primer Assay in human, mouse, rat ZFP91
     Search GNC Networks for ZFP91
     SABiosciences PCR Arrays including human, mouse, rat ZFP91
     Search Tocris compounds for ZFP91
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ZFP91 antibodies
     ZFP91 lysates
     Antibodies for ZFP91
     See all of Abcam's Antibodies, Kits and Proteins for ZFP91
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ZFP91
     Antibodies for ZFP91
     ELISAs for ZFP91
     CLIAs for ZFP91
     Search LifeMap BioReagents cell lines for ZFP91
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP91
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ZFP91
     Browse SwitchGear Promoter luciferase reporter plasmids for ZFP91
     Search ThermoFisher Antibodies for ZFP91
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP91
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFP91
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZFP91
    Customized:
     lentivirus for stable overexpression of ZFP91
     lentivirus expression plasmids for stable overexpression of ZFP91
     adenovirus for overexpression of ZFP91
     LSBio Antibodies in human, mouse, rat for ZFP91
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZFP91 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4