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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFP91 Gene

protein-coding   GIFtS: 41
GCID: GC11P058347

ZFP91 zinc finger protein

(Previous names: zinc finger protein homologous to Zfp91 in mouse, zinc...)
 Explore 2 diseases affiliated with
ZFP91 via our new
 Human Malady Compendium 
Biological research products
for ZFP91
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ZFP91 Zinc Finger Protein1 2     DSM-82
ZNF7571 2 3     ZFP-912
PZF1 2     Drug Resistance-Associated Sequence In Melanoma 82
Zinc Finger Protein Homologous To Zfp91 In Mouse1 2     E3 Ubiquitin-Protein Ligase ZFP912
Zinc Finger Protein 7572 3     Penta Zinc Finger Protein2
Zinc Finger Protein 91 Homolog2 3     EC 6.3.2.-3
Zinc Finger Protein 91 Homolog (Mouse)1     Zfp-913
DMS-82     

External Ids:    HGNC: 149831   Entrez Gene: 808292   Ensembl: ENSG000001866607   UniProtKB: Q96JP53   
ORGUL members:         
NONCODE:n406578    

Export aliases for ZFP91 gene to outside databases

Previous GC identifers: GC11P060740 GC11P059860 GC11P058597 GC11P058122 GC11P058104 GC11P054694


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZFP91:
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type
domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein
functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative
splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the
downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of
ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2.
(provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: ZFP91_HUMAN, Q96JP5
Function: Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to
stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway.
May also play an important role in cell proliferation and/or anti-apoptosis

Gene Wiki entry for ZFP91


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFP91 gene promoter:
         C/EBPbeta   Sp1   HOXA3   C/EBPalpha   c-Ets-1   AREB6   FOXC1   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZFP91

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP91


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12

ZFP91 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP91 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P058347:  view genomic region     (about GC identifiers)

Start:
58,346,584 bp from pter      End:
58,388,515 bp from pter
Size:
41,932 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZFP91_HUMAN, Q96JP5 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase ZFP91  
Size: 570 amino acids; 63445 Da
Subunit: Interacts with MAP3K14/NIK
Subcellular location: Nucleus
Miscellaneous: In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or
HECT domain) known to mediate E3 ligase activity
Sequence caution: Sequence=AAL09963.1; Type=Frameshift; Positions=72, 80;
Secondary accessions: A6NHC4 A8MSG7 Q86V47 Q96JP4 Q96QA3
Alternative splicing: 2 isoforms:  Q96JP5-1   Q96JP5-2   

Explore the universe of human proteins at neXtProt for ZFP91: NX_Q96JP5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96JP5

  • ZFP91 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001183980.1  NP_444251.1  

    ENSEMBL proteins: 
     ENSP00000339030  

    Human Recombinant Protein Products: 
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    Uscn Proteins for ZFP91

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--


    ZFP91 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZFP91 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96JP5

    ProtoNet protein and cluster: Q96JP5

    UniProtKB/Swiss-Prot: ZFP91_HUMAN, Q96JP5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZFP91_HUMAN, Q96JP5
    Function: Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to
    stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway.
    May also play an important role in cell proliferation and/or anti-apoptosis

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
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    hsa-miR-549 hsa-miR-323-3p hsa-miR-520e hsa-miR-607 hsa-miR-520f hsa-miR-3194-5p hsa-miR-640 hsa-miR-188-5p
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0008270zinc ion binding IEA--


    ZFP91 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ZFP91:
     Decreased viability with pacli  Increased cell number in G1, a 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: ZFP91_HUMAN, Q96JP5
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFP91

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/12 Interacting proteins for ZFP91 (Q96JP53 ENSP000003390304) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    CENPAP494503, ENSP000003368684I2D: score=1 STRING: ENSP00000336868
    RNPS1Q152873, ENSP000003158594I2D: score=1 STRING: ENSP00000315859
    PACSIN1Q9BY113I2D: score=2 
    FOSP011003I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007250activation of NF-kappaB-inducing kinase activity IDA--
    GO:0070534protein K63-linked ubiquitination IDA--


    ZFP91 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFP91
    Search CenterWatch for drugs/clinical trials and news about ZFP91 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFP91 gene (2 alternative transcripts): 
    NM_001197051.1  NM_053023.4  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000316059(uc001nmx.4 uc001nmy.4)

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    hsa-miR-549 hsa-miR-323-3p hsa-miR-520e hsa-miR-607 hsa-miR-520f hsa-miR-3194-5p hsa-miR-640 hsa-miR-188-5p
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    24/493 AceView cDNA sequences (see all 493):

    NM_170768 BP350072 BQ716412 CK299809 BI518760 AW275227 BF058569 AI684356 
    BM667429 AI351069 AA811228 AW675604 AI186641 AI858235 CR600105 BQ014616 
    AA995332 AW205563 AA889025 BE748113 AA758013 AI344111 CD516544 BU192588 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZFP91    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
    SP1:              -                                               -     -     -                     
    SP2:              -                                                                                 
    SP3:              -                                                                                 
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for ZFP91

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFP91 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZFP91 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFP91

    UniProtKB/Swiss-Prot: ZFP91_HUMAN, Q96JP5
    Tissue specificity: Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific

        SABiosciences Expression via Pathway-Focused PCR Arrays including ZFP91: 
              Growth Factors in human mouse rat
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              Obesity in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZFP91 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ZFP911 zinc finger protein 91 homolog (mouse) 74.88(n)
    78.8(a)
      423128  XM_001231963.2  XP_001231964.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZFP916
    --
    74(a)
    1 → many
    1(91283282-91297185)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.244722 Xenopus laevis transcribed sequence with strong similarity more 79.15(n)    CB199311.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-113e8.101 si:ch211-113e8.10 60.65(n)
    62.1(a)
      555616  XM_678183.5  XP_683275.2 


    ENSEMBL Gene Tree for ZFP91 (if available)
    TreeFam Gene Tree for ZFP91 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFP91 gene
    ZNF6922  ZNF6532  ENSG000002674772  ZFP91-CNTF2  ZNF2762  
    5 SIMAP similar genes for ZFP91 using alignment to 2 protein entries:     ZFP91_HUMAN (see all proteins):
    ZFP91-CNTF    ZNF702P    ZNF323    ZNF692    ZNF844

    ZFP91 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZFP91
    PGOHUM00000240283


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/661 NCBI SNPs in ZFP91 are shown (see all 661    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1417971081,2
    --58347743(+) GTTTTA/GTCTTT 3 -- int10--------
    rs9485621,2
    C,F,O,A,H,--58347765(-) TACATT/CTAAAA 3 -- int126Minor allele frequency- C:0.13EA NA NS WA 2978
    rs799042891,2
    C,F,--58347844(+) ACATGA/GACAGG 3 -- int12Minor allele frequency- G:0.03WA NA 238
    rs1918898781,2
    --58347848(+) GAACAA/GGTGGC 3 -- int10--------
    rs57921131,2
    C,--58347973(+) AAACA-/TCA   
       TTAGT
    GACCT
    3 -- int10--------
    rs605927701,2
    C,--58348112(+) AATAGA/CTTTAA 3 -- int12Minor allele frequency- C:0.06WA 120
    rs171527431,2
    C,F,H,--58348254(+) TTTGAA/GTGTCA 3 -- int111Minor allele frequency- G:0.07NA NS EA WA 1312
    rs1841388661,2
    --58348281(+) TTAGAG/TAATTT 3 -- int10--------
    rs1462451311,2
    --58348325(+) ATCTGC/TACTTA 3 -- int10--------
    rs112295351,2
    C,F,H,--58348386(+) ACAAAA/GATTTT 3 -- int17Minor allele frequency- G:0.13NS EA WA NA 768

    HapMap Linkage Disequilibrium report for ZFP91 (58346584 - 58388515 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZFP91: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZFP91 for disorders           About GeneDecksing

    2 diseases for ZFP91:    About MalaCards
    melanoma    leukemia

    Human Genome Epidemiology (HuGE) Navigator: ZFP91 (1 document)

    Export disorders for ZFP91 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFP91 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with ZFP91)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. (PubMed id 20682767)1, 2, 3 Jin X.... Lee J.J. (2010)
    2. Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. (PubMed id 12738986)1, 2, 3 Unoki M.... Nakamura Y. (2003)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    10. Zinc-finger protein 91 plays a key role in LIGHT-indu ced activation of non-canonical NF-I_B pathway. (PubMed id 20804734)1 Jin H.R....Lee J.J. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80829 HGNC: 14983 AceView: CNTF Ensembl:ENSG00000186660 euGenes: HUgn80829
    ECgene: ZFP91 H-InvDB: ZFP91

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFP91 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for ZFP91 gene:
    Search GeneIP for patents involving ZFP91

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