Aliases for ZFP90 Gene
External Ids for ZFP90 Gene
Previous GeneCards Identifiers for ZFP90 Gene
This gene encodes a member of the zinc finger protein family that modulates gene expression. The encoded protein derepresses the transcription of certain fetal cardiac genes and may contribute to the genetic reprogramming that occurs during the development of heart failure. Genome wide association studies have identified this gene among ulcerative colitis risk loci. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]
GeneCards Summary for ZFP90 Gene
ZFP90 (ZFP90 Zinc Finger Protein) is a Protein Coding gene. Diseases associated with ZFP90 include Spastic Paraplegia, Optic Atrophy, And Neuropathy and Ulcerative Colitis. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is ZNF354A.
UniProtKB/Swiss-Prot for ZFP90 Gene
May function as a repressor or silencer protein, and most likely exerts its repressing activity upon zinc-dependent binding to DNA. May be involved in proper spermatogenesis by repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid cell state (By similarity). Isoform 2 acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg) (PubMed:23543754).