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Aliases for ZFP90 Gene

Aliases for ZFP90 Gene

  • ZFP90 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 756 3 4
  • Zfp-90 3 4
  • ZNF756 3 4
  • FOXP3-Interacting KRAB Domain-Containing Protein 3
  • Zinc Finger Protein 90 Homolog (Mouse) 2
  • Zinc Finger Protein 90 Homolog 3
  • Zinc Finger Protein 476 3
  • KIAA1954 4
  • NK10 3
  • FIK 3

External Ids for ZFP90 Gene

Previous GeneCards Identifiers for ZFP90 Gene

  • GC16P068308
  • GC16P068297
  • GC16P068316
  • GC16P067130
  • GC16U900523
  • GC16P068573
  • GC16P054446
  • GC16P068563

Summaries for ZFP90 Gene

Entrez Gene Summary for ZFP90 Gene

  • This gene encodes a member of the zinc finger protein family that modulates gene expression. The encoded protein derepresses the transcription of certain fetal cardiac genes and may contribute to the genetic reprogramming that occurs during the development of heart failure. Genome wide association studies have identified this gene among ulcerative colitis risk loci. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]

GeneCards Summary for ZFP90 Gene

ZFP90 (ZFP90 Zinc Finger Protein) is a Protein Coding gene. Diseases associated with ZFP90 include Spastic Paraplegia, Optic Atrophy, And Neuropathy. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is ZNF569.

UniProtKB/Swiss-Prot for ZFP90 Gene

  • Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.

  • Isoform 2: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP90 Gene

Genomics for ZFP90 Gene

Regulatory Elements for ZFP90 Gene

Enhancers for ZFP90 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F068530 0.9 ENCODE 47 +0.1 76 1.4 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF121 SLC30A9 ZFP90 UTP4 ENSG00000259797 RNU4-36P
GH16F068528 0.8 ENCODE 46.8 -1.3 -1258 0.2 ARID4B SIN3A ZNF48 ZNF2 SLC30A9 ZNF143 ZNF207 NFYC MXD4 MIER2 ZFP90 LOC105371321
GH16F068538 0.4 ENCODE 46.8 +9.6 9553 2.2 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 GLIS2 ZFP90 UTP4 PSKH1 RNU4-36P ENSG00000260084
GH16F068520 1 Ensembl ENCODE 35.4 -9.2 -9190 1.0 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 SLC30A9 ZNF207 ZNF143 NFYC ZFP90 SMPD3 PRMT7 SLC7A6OS ENSG00000262514 LOC105371321
GH16F068640 0.5 ENCODE 29.5 +111.1 111125 1.1 ZFP90 ENSG00000260577 CDH3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZFP90 on UCSC Golden Path with GeneCards custom track

Promoters for ZFP90 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000149284 210 1401 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF121 SLC30A9
ENSR00001802423 -1190 201 ARID4B SIN3A ZNF48 ZNF2 SLC30A9 ZNF143 ZNF207 NFYC MXD4 MIER2

Genomic Location for ZFP90 Gene

Chromosome:
16
Start:
68,530,090 bp from pter
End:
68,576,072 bp from pter
Size:
45,983 bases
Orientation:
Plus strand

Genomic View for ZFP90 Gene

Genes around ZFP90 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP90 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP90 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP90 Gene

Proteins for ZFP90 Gene

  • Protein details for ZFP90 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF47-ZFP90_HUMAN
    Recommended name:
    Zinc finger protein 90 homolog
    Protein Accession:
    Q8TF47
    Secondary Accessions:
    • B2RU00
    • B3KVE7
    • L7S2P3
    • Q49AD1
    • Q96MQ6

    Protein attributes for ZFP90 Gene

    Size:
    636 amino acids
    Molecular mass:
    73031 Da
    Quaternary structure:
    • Interacts (via N- and C-termini) with REST (via zinc-finger DNA-binding domain); the interaction inhibits REST repressor activity (PubMed:21284946). Isoform 2: Interacts with FOXP3 and TRIM28 (PubMed:23543754).
    SequenceCaution:
    • Sequence=AX721106; Type=Frameshift; Positions=341, 358, 370; Evidence={ECO:0000305}; Sequence=BAB71228.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG53759.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFP90 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP90 Gene

Post-translational modifications for ZFP90 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFP90 Gene

Domains & Families for ZFP90 Gene

Gene Families for ZFP90 Gene

Suggested Antigen Peptide Sequences for ZFP90 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF47

UniProtKB/Swiss-Prot:

ZFP90_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFP90: view

Function for ZFP90 Gene

Molecular function for ZFP90 Gene

UniProtKB/Swiss-Prot Function:
Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.
UniProtKB/Swiss-Prot Function:
Isoform 2: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg).

Gene Ontology (GO) - Molecular Function for ZFP90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP90: view
genes like me logo Genes that share phenotypes with ZFP90: view

Animal Model Products

miRNA for ZFP90 Gene

miRTarBase miRNAs that target ZFP90

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP90 Gene

Localization for ZFP90 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP90 Gene

Nucleus. Note=Colocalizes with REST in the nucleus. {ECO:0000250 UniProtKB:Q61967}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP90 Gene COMPARTMENTS Subcellular localization image for ZFP90 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ZFP90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP90: view

Pathways & Interactions for ZFP90 Gene

SuperPathways for ZFP90 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP90: view

Pathways by source for ZFP90 Gene

2 Reactome pathways for ZFP90 Gene

Interacting Proteins for ZFP90 Gene

Gene Ontology (GO) - Biological Process for ZFP90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0043392 negative regulation of DNA binding IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZFP90: view

No data available for SIGNOR curated interactions for ZFP90 Gene

Transcripts for ZFP90 Gene

mRNA/cDNA for ZFP90 Gene

(8) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP90 Gene

ZFP90 zinc finger protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP90 Gene

No ASD Table

Relevant External Links for ZFP90 Gene

GeneLoc Exon Structure for
ZFP90
ECgene alternative splicing isoforms for
ZFP90

Expression for ZFP90 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFP90 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFP90 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFP90 Gene



Protein tissue co-expression partners for ZFP90 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFP90 Gene:

ZFP90

SOURCE GeneReport for Unigene cluster for ZFP90 Gene:

Hs.461074

mRNA Expression by UniProt/SwissProt for ZFP90 Gene:

Q8TF47-ZFP90_HUMAN
Tissue specificity: Expressed in heart (PubMed:21284946). Isoform 2: Highly expressed in regulatory T-cells (Treg) (PubMed:23543754).
genes like me logo Genes that share expression patterns with ZFP90: view

Primer Products

No data available for mRNA differential expression in normal tissues for ZFP90 Gene

Orthologs for ZFP90 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP90 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP90 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia ZFP90 34 35
  • 91.49 (n)
cow
(Bos Taurus)
Mammalia ZFP90 34 35
  • 90.01 (n)
rat
(Rattus norvegicus)
Mammalia Zfp90 34
  • 84.99 (n)
mouse
(Mus musculus)
Mammalia Zfp90 34 16 35
  • 83.12 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 52 (a)
OneToMany
Species where no ortholog for ZFP90 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP90 Gene

ENSEMBL:
Gene Tree for ZFP90 (if available)
TreeFam:
Gene Tree for ZFP90 (if available)

Paralogs for ZFP90 Gene

(470) SIMAP similar genes for ZFP90 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ZFP90: view

Variants for ZFP90 Gene

Sequence variations from dbSNP and Humsavar for ZFP90 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10163413 -- 68,555,439(+) GTGGA(C/T)GTGGT intron-variant
rs1043275 -- 68,566,942(+) CCACT(C/T)TGAAA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1043285 -- 68,567,016(+) GCTTT(C/T)TTAGT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10538200 -- 68,551,436(+) TTTTT(-/TTT)GGAGA intron-variant
rs10548814 -- 68,546,363(+) CAAAA(-/TTC)TTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP90 Gene

Variant ID Type Subtype PubMed ID
nsv457515 CNV gain 19166990
nsv476841 CNV novel sequence insertion 20440878
nsv572908 CNV gain 21841781

Variation tolerance for ZFP90 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP90 Gene

Human Gene Mutation Database (HGMD)
ZFP90
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP90

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP90 Gene

Disorders for ZFP90 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFP90 Gene - From: GeneCards

Disorder Aliases PubMed IDs
spastic paraplegia, optic atrophy, and neuropathy
  • spastic paraplegia-optic atrophy-neuropathy syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ZFP90 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZFP90

Genetic Association Database (GAD)
ZFP90
Human Genome Epidemiology (HuGE) Navigator
ZFP90
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP90
genes like me logo Genes that share disorders with ZFP90: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFP90 Gene

Publications for ZFP90 Gene

  1. Developmentally regulated mouse gene NK10 encodes a zinc finger repressor protein with differential DNA-binding domains. (PMID: 7576184) Lange R. … Heinlein U.A. (DNA Cell Biol. 1995) 2 3 22 64
  2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay J.L. … van den Oord E.J. (Neuropsychopharmacology 2011) 3 46 64
  3. Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes. (PMID: 21284946) Hata L. … Nakao K. (J. Mol. Cell. Cardiol. 2011) 3 4 64
  4. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 3 46 64
  5. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa J.R. … Goldstein D. (PLoS ONE 2011) 3 46 64

Products for ZFP90 Gene

Sources for ZFP90 Gene

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