Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZFP90 Gene

Aliases for ZFP90 Gene

  • ZFP90 Zinc Finger Protein 2 3
  • Zinc Finger Protein 756 3 4
  • KIAA1954 4 6
  • Zfp-90 3 4
  • ZNF756 3 4
  • NK10 3 6
  • FOXP3-Interacting KRAB Domain-Containing Protein 3
  • Zinc Finger Protein 90 Homolog (Mouse) 2
  • Zinc Finger Protein 90 Homolog 3
  • Zinc Finger Protein 476 3
  • FIK 3

External Ids for ZFP90 Gene

Summaries for ZFP90 Gene

Entrez Gene Summary for ZFP90 Gene

  • This gene encodes a member of the zinc finger protein family that modulates gene expression. The encoded protein derepresses the transcription of certain fetal cardiac genes and may contribute to the genetic reprogramming that occurs during the development of heart failure. Genome wide association studies have identified this gene among ulcerative colitis risk loci. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]

GeneCards Summary for ZFP90 Gene

ZFP90 (ZFP90 Zinc Finger Protein) is a Protein Coding gene. Diseases associated with ZFP90 include spastic paraplegia, optic atrophy, and neuropathy. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription. An important paralog of this gene is ZNF529.

UniProtKB/Swiss-Prot for ZFP90 Gene

  • May function as a repressor or silencer protein, and most likely exerts its repressing activity upon zinc-dependent binding to DNA. May be involved in proper spermatogenesis by repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid cell state (By similarity). Isoform 2 acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg) (PubMed:23543754).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP90 Gene

Genomics for ZFP90 Gene

Genomic Location for ZFP90 Gene

Start:
68,530,090 bp from pter
End:
68,576,072 bp from pter
Size:
45,983 bases
Orientation:
Plus strand

Genomic View for ZFP90 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFP90 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP90 Gene

Regulatory Elements for ZFP90 Gene

Proteins for ZFP90 Gene

  • Protein details for ZFP90 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF47-ZFP90_HUMAN
    Recommended name:
    Zinc finger protein 90 homolog
    Protein Accession:
    Q8TF47
    Secondary Accessions:
    • B2RU00
    • B3KVE7
    • L7S2P3
    • Q49AD1
    • Q96MQ6

    Protein attributes for ZFP90 Gene

    Size:
    636 amino acids
    Molecular mass:
    73031 Da
    Quaternary structure:
    • Isoform 2 interacts with FOXP3 and TRIM28.
    SequenceCaution:
    • Sequence=AX721106; Type=Frameshift; Positions=341, 358, 370; Evidence={ECO:0000305}; Sequence=BAB71228.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG53759.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFP90 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP90 Gene

Proteomics data for ZFP90 Gene at MOPED

Post-translational modifications for ZFP90 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFP90 Gene

Domains for ZFP90 Gene

Gene Families for ZFP90 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZFP90 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF47

UniProtKB/Swiss-Prot:

ZFP90_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q8TF47
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q8TF47
Similarity:
  • Contains 13 C2H2-type zinc fingers.:
    • Q8TF47
genes like me logo Genes that share domains with ZFP90: view

Function for ZFP90 Gene

Molecular function for ZFP90 Gene

UniProtKB/Swiss-Prot Function: May function as a repressor or silencer protein, and most likely exerts its repressing activity upon zinc-dependent binding to DNA. May be involved in proper spermatogenesis by repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid cell state (By similarity). Isoform 2 acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg) (PubMed:23543754).

Gene Ontology (GO) - Molecular Function for ZFP90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP90: view

miRNA for ZFP90 Gene

miRTarBase miRNAs that target ZFP90

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFP90 Gene

Localization for ZFP90 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP90 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP90 Gene COMPARTMENTS Subcellular localization image for ZFP90 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZFP90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP90: view

Pathways for ZFP90 Gene

SuperPathways for ZFP90 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP90: view

Pathways by source for ZFP90 Gene

2 Reactome pathways for ZFP90 Gene

Interacting Proteins for ZFP90 Gene

Gene Ontology (GO) - Biological Process for ZFP90 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0043392 negative regulation of DNA binding IEA --
GO:0045892 negative regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with ZFP90: view

Transcripts for ZFP90 Gene

mRNA/cDNA for ZFP90 Gene

(11) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP90 Gene

ZFP90 zinc finger protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP90 Gene

No ASD Table

Relevant External Links for ZFP90 Gene

GeneLoc Exon Structure for
ZFP90
ECgene alternative splicing isoforms for
ZFP90

Expression for ZFP90 Gene

mRNA expression in normal human tissues for ZFP90 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFP90 Gene

SOURCE GeneReport for Unigene cluster for ZFP90 Gene Hs.461074

mRNA Expression by UniProt/SwissProt for ZFP90 Gene

Q8TF47-ZFP90_HUMAN
Tissue specificity: Isoform 2 is highly expressed in the regulatory T-cells (Treg).
genes like me logo Genes that share expressions with ZFP90: view

No data available for mRNA differential expression in normal tissues for ZFP90 Gene

Orthologs for ZFP90 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP90 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP90 35
  • 99.69 (n)
  • 99.21 (a)
ZFP90 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFP90 35
  • 90.01 (n)
  • 90.54 (a)
ZFP90 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP90 35
  • 91.49 (n)
  • 92.39 (a)
ZFP90 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp90 35
  • 83.12 (n)
  • 82.59 (a)
Zfp90 16
Zfp90 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp90 35
  • 84.99 (n)
  • 83.89 (a)
Species with no ortholog for ZFP90:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP90 Gene

ENSEMBL:
Gene Tree for ZFP90 (if available)
TreeFam:
Gene Tree for ZFP90 (if available)

Paralogs for ZFP90 Gene

Selected SIMAP similar genes for ZFP90 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ZFP90: view

Variants for ZFP90 Gene

Sequence variations from dbSNP and Humsavar for ZFP90 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs7118 -- 68,566,952(+) ACTCA(G/T)CACAT utr-variant-3-prime, intron-variant
rs698709 -- 68,551,996(+) atctc(A/G)tgatc intron-variant
rs821166 -- 68,544,578(-) GAGCT(C/T)CTGTA intron-variant
rs821167 -- 68,543,319(-) TTTTT(A/C)TCCTA intron-variant
rs821168 -- 68,541,257(-) agttc(A/G)agacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP90 Gene

Variant ID Type Subtype PubMed ID
nsv457515 CNV Gain 19166990

Relevant External Links for ZFP90 Gene

HapMap Linkage Disequilibrium report
ZFP90
Human Gene Mutation Database (HGMD)
ZFP90

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP90 Gene

Disorders for ZFP90 Gene

Relevant External Links for ZFP90

Genetic Association Database (GAD)
ZFP90
Human Genome Epidemiology (HuGE) Navigator
ZFP90
genes like me logo Genes that share disorders with ZFP90: view

No data available for UniProtKB/Swiss-Prot for ZFP90 Gene

Publications for ZFP90 Gene

  1. Developmentally regulated mouse gene NK10 encodes a zinc finger repressor protein with differential DNA-binding domains. (PMID: 7576184) Lange R. … Heinlein U.A. (DNA Cell Biol. 1995) 2 3 23
  2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  3. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 3 48
  4. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa J.R. … Goldstein D. (PLoS ONE 2011) 3 48
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ZFP90 Gene

Sources for ZFP90 Gene

Back to Top

Content