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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFP82 Gene

protein-coding   GIFtS: 44
GCID: GC19M036874

ZFP82 Zinc Finger Protein

(Previous names: zinc finger protein 545, zinc finger protein 82 homolog...)
(Previous symbol: ZNF545)
  Search for ZFP82
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ZFP82 Zinc Finger Protein1 2     zfp-822
Zinc Finger Protein 5451 2 3     Zinc Finger Protein 82 Homolog2
ZNF5451 2 3     Zinc Finger Protein 852
Zinc Finger Protein 821     KIAA19483
Zinc Finger Protein 82 Homolog (Mouse)1     Zfp-823

External Ids:    HGNC: 286821   Entrez Gene: 2844062   Ensembl: ENSG000001810077   UniProtKB: Q8N1413   

Export aliases for ZFP82 gene to outside databases

Previous GC identifers: GC19M041577 GC19M036882 GC19M033351


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZFP82 Gene: 
ZFP82 (ZFP82 zinc finger protein) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF79.

UniProtKB/Swiss-Prot: ZFP82_HUMAN, Q8N141
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFP82 gene promoter:
         Elk-1   Pax-5   Tal-1beta   LCR-F1   Arnt   CREB   Pax-3   deltaCREB   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFP82 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFP82

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP82


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.13

ZFP82 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP82 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M036874:  view genomic region     (about GC identifiers)

Start:
36,874,022 bp from pter      End:
36,909,558 bp from pter
Size:
35,537 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZFP82_HUMAN, Q8N141 (See protein sequence)
Recommended Name: Zinc finger protein 82 homolog  
Size: 532 amino acids; 62578 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB85534.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB85534.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: Q8NC63 Q8TF53

Explore the universe of human proteins at neXtProt for ZFP82: NX_Q8N141

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N141

  • ZFP82 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_597723.1  
    ENSEMBL proteins: 
     ENSP00000468212   ENSP00000431265   ENSP00000446080  

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    Cloud-Clone Corp. Proteins for ZFP82 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZFP82 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N141

    ProtoNet protein and cluster: Q8N141

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZFP82_HUMAN, Q8N141
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZFP82 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFP82_HUMAN, Q8N141
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZFP82 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZFP82:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFP82 
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    SwitchGear 3'UTR luciferase reporter plasmidZFP82 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFP82

    2 Interacting proteins for ZFP82 (Q8N1413) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDX1P479023I2D: score=1 
    EWSR1Q018443I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZFP82 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFP82

    Search CenterWatch for drugs/clinical trials and news about ZFP82

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFP82 gene: 
    NM_133466.2  

    Unigene Cluster for ZFP82:

    ZFP82 zinc finger protein
    Hs.558734  [show with all ESTs]
    Unigene Representative Sequence: AB075828
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445543 ENST00000590993 ENST00000392161(uc002ody.1) ENST00000392171

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFP82:
    hsa-miR-548p hsa-miR-181c hsa-miR-545 hsa-miR-181a hsa-miR-3918 hsa-miR-181d hsa-miR-181b hsa-miR-4262
    SwitchGear 3'UTR luciferase reporter plasmidZFP82 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZFP82
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFP82
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP82
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFP82
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP82

    Additional mRNA sequence: 

    AB075828.1 AK074942.1 AK315709.1 AL834267.1 BC032577.2 GU388429.1 

    6 DOTS entries:

    DT.91976293  DT.100033660  DT.430348  DT.92065518  DT.409430  DT.438951 

    24/67 AceView cDNA sequences (see all 67):

    F05579 AL834267 NM_133466 BU147182 F05578 BU618382 AA580143 AA330257 
    BX281147 BX111412 AA485059 BE464428 AA777644 BE072066 BQ425401 BM680223 
    BI492345 AI969283 BF679498 BU633705 AA682517 AB075828 BC032577 AI631652 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFP82 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATATAATA
    ZFP82 Expression
    About this image


    Genevestigator expression for ZFP82

    SOURCE GeneReport for Unigene cluster: Hs.558734
        SABiosciences Custom PCR Arrays for ZFP82
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP82

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZFP82 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp821 , 5 zinc finger protein 821, 5 82.7(n)1
    85.47(a)1
      7 (17.26 cM)5
    3305021  NM_177889.51  NP_808557.21 
     300544895 


    ENSEMBL Gene Tree for ZFP82 (if available)
    TreeFam Gene Tree for ZFP82 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFP82 gene
    ZNF792  ZNF5702  ZFP302  ZNF5292  ZNF7902  ZNF4832  ZNF3832  ZNF1812  
    ZNF2872  ZNF5822  ZNF4712  ZNF2502  ZNF8792  ZNF354C2  ZNF742  ZNF5832  
    ZNF4852  ZNF4542  ZFP902  ZFP142  ZNF3312  ZNF354A2  ZNF4612  ZNF3112  
    ZNF354B2  ZNF3452  ZNF5682  ZNF342  ZNF5652  
    18/499 SIMAP similar genes for ZFP82 using alignment to 4 protein entries:     ZFP82_HUMAN (see all proteins) (see all similar genes):
    ZFP30    ZNF818P    ZFP14    kr-znf3    MGC12518    POM121C
    ZFS-4    ZNF665    ZNF78L1    DKFZp686B16128    ZNF232    HZF36
    ZNF107    ZNF721    ZNF493    DKFZp571N1833    DKFZp686H20223    ZFP3

    ZFP82 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/603 SNPs in ZFP82 are shown (see all 603)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs360980661,2
    C--36882374(+) TGTAG-/A/TTTTTT 1 -- int10--------
    rs1163274941,2
    --36882390(+) TTTTTG/TAGACA 1 -- int10--------
    rs730438661,2
    --36882532(+) CAGCTA/GATTTT 1 -- int10--------
    rs1908292761,2
    --36882663(+) CTCACC/TTGGTC 1 -- int10--------
    rs1810063981,2
    --36882781(+) GGCATA/TTCTAT 1 -- int10--------
    rs29675171,2
    C,F,A,H--36882828(+) AAAAAG/TAAATA 1 -- int124Minor allele frequency- T:0.35NS EA NA WA CSA 2227
    rs58279571,2
    C,F--36882921(+) TGGGCC/-AGGGG 1 -- ut314Minor allele frequency- -:0.38NA 8
    rs1138497511,2
    C--36882921(+) TTGGGC/GCAGGG 1 -- ut310--------
    rs1860376881,2
    --36883095(+) CTCTAC/TGTAGT 1 -- ut310--------
    rs1459375271,2
    C--36883258(+) CAGTC-/ACAGAGGGATGT
    AGATTCCTGTATACA
    ACAGA
    1 -- cds10--------

    HapMap Linkage Disequilibrium report for ZFP82 (36874022 - 36909558 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZFP82:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833816CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFP82
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFP82

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFP82 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZFP82)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Zinc-finger protein 545 is a novel tumour suppressor t hat acts by inhibiting ribosomal RNA transcription in gastric cancer. (PubMed id 22580414)1 Wang S....Yu J. (2013)
    5. Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284406 HGNC: 28682 AceView: ZNF545 Ensembl:ENSG00000181007 euGenes: HUgn284406
    ECgene: ZFP82 H-InvDB: ZFP82

    (According to HUGE)
    About This Section
    HUGE: KIAA1948

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFP82 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFP82 gene:
    Search GeneIP for patents involving ZFP82

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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