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Aliases for ZFP69B Gene

Aliases for ZFP69B Gene

  • ZFP69 Zinc Finger Protein B 2 3 5
  • Zinc Finger Protein 643 2 3 4
  • ZNF643 3 4
  • Zinc Finger Protein ZFP69B 3
  • Novel Zinc Finger Protein 3
  • ZKSCAN23B 3
  • ZSCAN54B 3

External Ids for ZFP69B Gene

Previous HGNC Symbols for ZFP69B Gene

  • ZNF643

Previous GeneCards Identifiers for ZFP69B Gene

  • GC01P040916

Summaries for ZFP69B Gene

GeneCards Summary for ZFP69B Gene

ZFP69B (ZFP69 Zinc Finger Protein B) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZFP69.

UniProtKB/Swiss-Prot for ZFP69B Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZFP69B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP69B Gene

Genomics for ZFP69B Gene

Regulatory Elements for ZFP69B Gene

Enhancers for ZFP69B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H040421 1.5 Ensembl ENCODE dbSUPER 12.9 -27.5 -27495 2 FOXA2 ATF1 MLX ARID4B FEZF1 DMAP1 YY1 MXD4 NFYC REST ZFP69 EXO5 PPIE ZFP69B SMAP2 ENSG00000227278 ENSG00000238186 LOC105378672 GC01P040432 GC01M040364
GH01H040413 0.9 ENCODE dbSUPER 12 -35.8 -35816 1 SOX5 SOX13 FOXA2 ZNF644 RARA NFIL3 RERE CEBPA TCF7 HNF4A SMAP2 ZFP69B COL9A2 LOC105378672 EXO5 ENSG00000231296 ZMPSTE24 ZFP69 RLF HEYL
GH01H040140 0.9 Ensembl ENCODE 11.3 -309.7 -309727 0 HLF CEBPB ELF1 GATAD2B DPF2 EP300 ZNF217 CTBP1 JUND GATA3 RLF ZFP69B COL9A2 PPT1 EXO5 ZMPSTE24 ENSG00000231296 TMCO2 PPIE PPIEL
GH01H040141 0.7 FANTOM5 11.3 -309.3 -309333 0 CEBPB ELF1 GATAD2B DPF2 EP300 GATA3 CTBP1 MTA1 ZNF350 RCOR1 RLF ZFP69B COL9A2 PPT1 EXO5 ZMPSTE24 ENSG00000231296 TMCO2 PPIE PPIEL
GH01H040488 0.3 FANTOM5 11.7 +38.4 38352 0 ZNF684 ENSG00000227278 ENSG00000238186 ZFP69B EXO5 GC01P040495 ZFP69
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFP69B on UCSC Golden Path with GeneCards custom track

Promoters for ZFP69B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005217 114 1601 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 CBX5 ZNF143 ZNF207 FOS

Genomic Location for ZFP69B Gene

Chromosome:
1
Start:
40,450,086 bp from pter
End:
40,463,718 bp from pter
Size:
13,633 bases
Orientation:
Plus strand

Genomic View for ZFP69B Gene

Genes around ZFP69B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP69B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP69B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP69B Gene

Proteins for ZFP69B Gene

  • Protein details for ZFP69B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJL9-ZF69B_HUMAN
    Recommended name:
    Zinc finger protein ZFP69B
    Protein Accession:
    Q9UJL9
    Secondary Accessions:
    • Q5QPL4

    Protein attributes for ZFP69B Gene

    Size:
    534 amino acids
    Molecular mass:
    61481 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17498.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI19856.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFP69B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP69B Gene

Post-translational modifications for ZFP69B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP69B Gene

No data available for DME Specific Peptides for ZFP69B Gene

Domains & Families for ZFP69B Gene

Gene Families for ZFP69B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP69B Gene

Suggested Antigen Peptide Sequences for ZFP69B Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJL9

UniProtKB/Swiss-Prot:

ZF69B_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP69B: view

Function for ZFP69B Gene

Molecular function for ZFP69B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZFP69B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP69B: view
genes like me logo Genes that share phenotypes with ZFP69B: view

Animal Model Products

CRISPR Products

miRNA for ZFP69B Gene

miRTarBase miRNAs that target ZFP69B

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZFP69B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP69B Gene

Localization for ZFP69B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP69B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP69B gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFP69B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP69B: view

Pathways & Interactions for ZFP69B Gene

SuperPathways for ZFP69B Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP69B: view

Pathways by source for ZFP69B Gene

2 Reactome pathways for ZFP69B Gene

Gene Ontology (GO) - Biological Process for ZFP69B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZFP69B: view

No data available for SIGNOR curated interactions for ZFP69B Gene

Drugs & Compounds for ZFP69B Gene

No Compound Related Data Available

Transcripts for ZFP69B Gene

mRNA/cDNA for ZFP69B Gene

Unigene Clusters for ZFP69B Gene

ZFP69 zinc finger protein B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZFP69B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP69B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: - -
SP3:
SP4: -

Relevant External Links for ZFP69B Gene

GeneLoc Exon Structure for
ZFP69B
ECgene alternative splicing isoforms for
ZFP69B

Expression for ZFP69B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP69B Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFP69B Gene:

ZFP69B

SOURCE GeneReport for Unigene cluster for ZFP69B Gene:

Hs.133034
genes like me logo Genes that share expression patterns with ZFP69B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP69B Gene

Orthologs for ZFP69B Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP69B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF643 33
  • 99 (n)
ZFP69B 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF643 33
  • 89.58 (n)
ZFP69B 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFP69B 33
  • 87.85 (n)
-- 34
  • 16 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
OneToMany
Species where no ortholog for ZFP69B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP69B Gene

ENSEMBL:
Gene Tree for ZFP69B (if available)
TreeFam:
Gene Tree for ZFP69B (if available)

Paralogs for ZFP69B Gene

Paralogs for ZFP69B Gene

(457) SIMAP similar genes for ZFP69B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZFP69B: view

Variants for ZFP69B Gene

Sequence variations from dbSNP and Humsavar for ZFP69B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000057720 -- 40,452,814(+) GCAGA(C/T)GACTT intron-variant
rs1000088450 -- 40,452,495(+) TAAAC(C/T)TCACA intron-variant
rs1000354739 -- 40,459,277(+) CATAT(G/T)TTCAT intron-variant
rs1000360370 -- 40,465,263(+) AGAGT(A/G)TGTAA utr-variant-3-prime
rs1000694220 -- 40,464,072(+) TGATC(C/G/T)GCCCA intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZFP69B Gene

Variant ID Type Subtype PubMed ID
esv2763289 CNV loss 21179565
nsv546064 CNV gain 21841781

Variation tolerance for ZFP69B Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP69B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP69B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP69B Gene

Disorders for ZFP69B Gene

Relevant External Links for ZFP69B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP69B

No disorders were found for ZFP69B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP69B Gene

Publications for ZFP69B Gene

  1. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for ZFP69B Gene

Sources for ZFP69B Gene

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