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Aliases for ZFP69 Gene

Aliases for ZFP69 Gene

  • ZFP69 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 642 2 3 4
  • ZFP69 Zinc Finger Protein A 2 3
  • ZNF642 3 4
  • Zinc Finger Protein ZFP69 3
  • ZKSCAN23A 3
  • ZSCAN54A 3
  • ZFP69A 3

External Ids for ZFP69 Gene

Previous HGNC Symbols for ZFP69 Gene

  • ZNF642

Previous GeneCards Identifiers for ZFP69 Gene

  • GC01P040943

Summaries for ZFP69 Gene

GeneCards Summary for ZFP69 Gene

ZFP69 (ZFP69 Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFP69B.

UniProtKB/Swiss-Prot for ZFP69 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZFP69 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP69 Gene

Genomics for ZFP69 Gene

Regulatory Elements for ZFP69 Gene

Enhancers for ZFP69 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H040421 1.5 Ensembl ENCODE dbSUPER 23.8 -54.6 -54624 2.5 FOXA2 ATF1 MLX ARID4B FEZF1 DMAP1 YY1 MXD4 NFYC REST ZFP69 EXO5 PPIE ZFP69B SMAP2 ENSG00000227278 ENSG00000238186 LOC105378672 GC01P040432 GC01M040364
GH01H040372 1.8 FANTOM5 ENCODE dbSUPER 13.1 -101.4 -101363 5.9 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF766 PPIEL PPIE TRIT1 EXO5 SMAP2 ENSG00000259943 ENSG00000182109 RLF NFYC-AS1 LOC105378674
GH01H040690 1.4 ENCODE dbSUPER 16.4 +215.5 215487 4.4 ZFP64 DMAP1 YY1 SLC30A9 SP3 NFYC MEF2D ZNF610 GLIS1 NBN ENSG00000259943 RIMS3 EXO5 NFYC-AS1 RLF LOC105378674 ZFP69 SLFNL1 TRIT1 MIR30C1
GH01H040256 1.2 ENCODE 13 -219.5 -219507 3 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ZC3H11A ZFP41 PPIE PPIEL EXO5 TRIT1 ENSG00000259943 RLF NFYC-AS1 LOC105378672 ENSG00000182109 COL9A2
GH01H040449 1.1 ENCODE 13.6 -26.6 -26626 2.5 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 CBX5 ZNF143 ZNF207 FOS LOC105378672 ZFP69 EXO5 ENSG00000227278 ENSG00000238186 ZNF684 OXCT2 ZFP69B ENSG00000260920
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFP69 on UCSC Golden Path with GeneCards custom track

Promoters for ZFP69 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005218 286 1400 PKNOX1 ARID4B SIN3A ZNF2 GLIS2 ELK1 ZNF143 ZNF207 ATF7 RUNX3

Genomic Locations for ZFP69 Gene

Genomic Locations for ZFP69 Gene
19,129 bases
Plus strand

Genomic View for ZFP69 Gene

Genes around ZFP69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP69 Gene

Proteins for ZFP69 Gene

  • Protein details for ZFP69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein ZFP69
    Protein Accession:
    Secondary Accessions:
    • Q5SWM5
    • Q6ZWK8

    Protein attributes for ZFP69 Gene

    526 amino acids
    Molecular mass:
    61181 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC85492.1; Type=Erroneous termination; Positions=506; Note=Translated as Tyr.; Evidence={ECO:0000305};

neXtProt entry for ZFP69 Gene

Post-translational modifications for ZFP69 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP69 Gene

No data available for DME Specific Peptides for ZFP69 Gene

Domains & Families for ZFP69 Gene

Gene Families for ZFP69 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP69 Gene

Suggested Antigen Peptide Sequences for ZFP69 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP69: view

Function for ZFP69 Gene

Molecular function for ZFP69 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZFP69 Gene

Gene Ontology (GO) - Molecular Function for ZFP69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP69: view
genes like me logo Genes that share phenotypes with ZFP69: view

miRNA for ZFP69 Gene

miRTarBase miRNAs that target ZFP69

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP69 Gene

Localization for ZFP69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP69 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP69 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZFP69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP69: view

Pathways & Interactions for ZFP69 Gene

SuperPathways for ZFP69 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP69: view

Pathways by source for ZFP69 Gene

2 Reactome pathways for ZFP69 Gene

Interacting Proteins for ZFP69 Gene

Gene Ontology (GO) - Biological Process for ZFP69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZFP69: view

No data available for SIGNOR curated interactions for ZFP69 Gene

Drugs & Compounds for ZFP69 Gene

No Compound Related Data Available

Transcripts for ZFP69 Gene

mRNA/cDNA for ZFP69 Gene

Unigene Clusters for ZFP69 Gene

ZFP69 zinc finger protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP69 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: - - -

Relevant External Links for ZFP69 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFP69 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP69 Gene

Protein differential expression in normal tissues from HIPED for ZFP69 Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZFP69 Gene

Protein tissue co-expression partners for ZFP69 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFP69 Gene:


SOURCE GeneReport for Unigene cluster for ZFP69 Gene:

genes like me logo Genes that share expression patterns with ZFP69: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP69 Gene

Orthologs for ZFP69 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP69 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF642 33 34
  • 99.75 (n)
(Bos Taurus)
Mammalia ZFP69 33 34
  • 89.93 (n)
(Canis familiaris)
Mammalia ZNF642 33
  • 89.25 (n)
-- 34
  • 11 (a)
(Rattus norvegicus)
Mammalia Zfp69 33
  • 79.46 (n)
(Mus musculus)
Mammalia Zfp69 33 16 34
  • 78.21 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 40 (a)
Species where no ortholog for ZFP69 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP69 Gene

Gene Tree for ZFP69 (if available)
Gene Tree for ZFP69 (if available)

Paralogs for ZFP69 Gene

Paralogs for ZFP69 Gene

(461) SIMAP similar genes for ZFP69 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZFP69: view

Variants for ZFP69 Gene

Sequence variations from dbSNP and Humsavar for ZFP69 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000119744 -- 40,490,971(+) TTGAA(A/G)CTCCA intron-variant
rs1000602900 -- 40,475,797(+) ACCCA(A/G)GCTGA upstream-variant-2KB
rs1000988784 -- 40,475,398(+) TTAAA(C/G)TTAGT upstream-variant-2KB
rs1001054163 -- 40,493,049(+) GGTGA(A/C)ACTCC intron-variant
rs1001396657 -- 40,485,897(+) GTGAT(-/TTG/TTGTTG)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP69 Gene

Variant ID Type Subtype PubMed ID
nsv546064 CNV gain 21841781
nsv1160834 CNV deletion 26073780
esv2597296 CNV deletion 19546169

Variation tolerance for ZFP69 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP69 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP69 Gene

Disorders for ZFP69 Gene

Relevant External Links for ZFP69

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZFP69 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP69 Gene

Publications for ZFP69 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 60
  5. Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL. (PMID: 19578398) Scherneck S … Joost HG (PLoS genetics 2009) 3 60

Products for ZFP69 Gene

Sources for ZFP69 Gene

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