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Aliases for ZFP69 Gene

Aliases for ZFP69 Gene

  • ZFP69 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 642 2 3 4
  • ZFP69 Zinc Finger Protein A 2 3
  • ZNF642 3 4
  • ZKSCAN23A 3
  • ZSCAN54A 3
  • ZFP69A 3

External Ids for ZFP69 Gene

Previous HGNC Symbols for ZFP69 Gene

  • ZNF642

Previous GeneCards Identifiers for ZFP69 Gene

  • GC01P040943

Summaries for ZFP69 Gene

GeneCards Summary for ZFP69 Gene

ZFP69 (ZFP69 Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF514.

UniProtKB/Swiss-Prot for ZFP69 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP69 Gene

Genomics for ZFP69 Gene

Regulatory Elements for ZFP69 Gene

Promoters for ZFP69 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZFP69 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZFP69 Gene

Chromosome:
1
Start:
40,477,215 bp from pter
End:
40,496,343 bp from pter
Size:
19,129 bases
Orientation:
Plus strand

Genomic View for ZFP69 Gene

Genes around ZFP69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP69 Gene

Proteins for ZFP69 Gene

  • Protein details for ZFP69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AA0-ZFP69_HUMAN
    Recommended name:
    Zinc finger protein ZFP69
    Protein Accession:
    Q49AA0
    Secondary Accessions:
    • Q5SWM5
    • Q6ZWK8

    Protein attributes for ZFP69 Gene

    Size:
    526 amino acids
    Molecular mass:
    61181 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85492.1; Type=Erroneous termination; Positions=506; Note=Translated as Tyr.; Evidence={ECO:0000305};

neXtProt entry for ZFP69 Gene

Proteomics data for ZFP69 Gene at MOPED

Post-translational modifications for ZFP69 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP69 Gene

No data available for DME Specific Peptides for ZFP69 Gene

Domains & Families for ZFP69 Gene

Gene Families for ZFP69 Gene

Protein Domains for ZFP69 Gene

Suggested Antigen Peptide Sequences for ZFP69 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q49AA0

UniProtKB/Swiss-Prot:

ZFP69_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
  • Contains 1 SCAN box domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFP69: view

Function for ZFP69 Gene

Molecular function for ZFP69 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZFP69: view

Animal Model Products

miRNA for ZFP69 Gene

miRTarBase miRNAs that target ZFP69

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP69 Gene

Localization for ZFP69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP69 Gene

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ZFP69 Gene

Pathways & Interactions for ZFP69 Gene

SuperPathways for ZFP69 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP69: view

Pathways by source for ZFP69 Gene

2 Reactome pathways for ZFP69 Gene

Interacting Proteins for ZFP69 Gene

Gene Ontology (GO) - Biological Process for ZFP69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZFP69: view

No data available for SIGNOR curated interactions for ZFP69 Gene

Drugs & Compounds for ZFP69 Gene

No Compound Related Data Available

Transcripts for ZFP69 Gene

mRNA/cDNA for ZFP69 Gene

Unigene Clusters for ZFP69 Gene

ZFP69 zinc finger protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP69 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for ZFP69 Gene

GeneLoc Exon Structure for
ZFP69
ECgene alternative splicing isoforms for
ZFP69

Expression for ZFP69 Gene

mRNA expression in normal human tissues for ZFP69 Gene

Protein differential expression in normal tissues from HIPED for ZFP69 Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZFP69 Gene



SOURCE GeneReport for Unigene cluster for ZFP69 Gene Hs.434385

genes like me logo Genes that share expression patterns with ZFP69: view

Protein tissue co-expression partners for ZFP69 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFP69 Gene

Orthologs for ZFP69 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP69 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZFP69 35
  • 89.93 (n)
  • 87.57 (a)
ZFP69 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF642 35
  • 89.25 (n)
  • 88.68 (a)
-- 36
  • 11 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp69 35
  • 78.21 (n)
  • 75.27 (a)
Zfp69 16
Zfp69 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF642 35
  • 99.75 (n)
  • 99.24 (a)
ZNF642 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp69 35
  • 79.46 (n)
  • 76.16 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
OneToMany
Species with no ortholog for ZFP69:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP69 Gene

ENSEMBL:
Gene Tree for ZFP69 (if available)
TreeFam:
Gene Tree for ZFP69 (if available)

Paralogs for ZFP69 Gene

Paralogs for ZFP69 Gene

(461) SIMAP similar genes for ZFP69 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZFP69: view

Variants for ZFP69 Gene

Sequence variations from dbSNP and Humsavar for ZFP69 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_033583 -
rs4076058 -- 40,479,350(-) TGCCT(C/T)ACTGG utr-variant-5-prime
rs4291490 -- 40,477,484(+) CCGCC(A/G)GCCCC upstream-variant-2KB, utr-variant-5-prime
rs5773698 -- 40,478,149(+) CACAC(-/AC)GCCTA intron-variant
rs6681100 -- 40,478,569(+) tcaga(G/T)ttaat intron-variant

Variation tolerance for ZFP69 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP69 Gene

HapMap Linkage Disequilibrium report
ZFP69
Human Gene Mutation Database (HGMD)
ZFP69

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZFP69 Gene

Disorders for ZFP69 Gene

Relevant External Links for ZFP69

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP69

No disorders were found for ZFP69 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP69 Gene

Publications for ZFP69 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL. (PMID: 19578398) Scherneck S. … Joost H.G. (PLoS Genet. 2009) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZFP69 Gene

Sources for ZFP69 Gene

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