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Aliases for ZFP64 Gene

Aliases for ZFP64 Gene

  • ZFP64 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 338 2 3 4
  • ZNF338 3 4
  • Zinc Finger Protein 64 Homolog (Mouse) 2
  • Zinc Finger Protein 64 Homolog 3
  • Zinc Finger Protein 64 2
  • Zfp-64 4

External Ids for ZFP64 Gene

Previous HGNC Symbols for ZFP64 Gene

  • ZNF338

Previous GeneCards Identifiers for ZFP64 Gene

  • GC20U990053
  • GC20M050388
  • GC20M051338
  • GC20M051385
  • GC20M050133
  • GC20M050668
  • GC20M047448

Summaries for ZFP64 Gene

GeneCards Summary for ZFP64 Gene

ZFP64 (ZFP64 Zinc Finger Protein) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is RREB1.

UniProtKB/Swiss-Prot for ZFP64 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZFP64 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP64 Gene

Genomics for ZFP64 Gene

Regulatory Elements for ZFP64 Gene

Genomic Location for ZFP64 Gene

Chromosome:
20
Start:
52,051,663 bp from pter
End:
52,204,308 bp from pter
Size:
152,646 bases
Orientation:
Minus strand

Genomic View for ZFP64 Gene

Genes around ZFP64 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP64 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP64 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP64 Gene

Proteins for ZFP64 Gene

  • Protein details for ZFP64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPA5-ZF64A_HUMAN
    Recommended name:
    Zinc finger protein 64 homolog, isoforms 1 and 2
    Protein Accession:
    Q9NPA5
    Secondary Accessions:
    • Q9NTS7
    • Q9NVH4

    Protein attributes for ZFP64 Gene

    Size:
    681 amino acids
    Molecular mass:
    74644 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZFP64 Gene

    Alternative splice isoforms for ZFP64 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for ZFP64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTW7-ZF64B_HUMAN
    Recommended name:
    Zinc finger protein 64 homolog, isoforms 3 and 4
    Protein Accession:
    Q9NTW7
    Secondary Accessions:
    • A2A2N4
    • Q53H69
    • Q53XQ1
    • Q5JWM0
    • Q5JWM1
    • Q8WU98
    • Q9H9P1

    Protein attributes for ZFP64 Gene

    Size:
    645 amino acids
    Molecular mass:
    72217 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZFP64 Gene

neXtProt entry for ZFP64 Gene

Proteomics data for ZFP64 Gene at MOPED

Post-translational modifications for ZFP64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFP64 Gene

Domains & Families for ZFP64 Gene

Gene Families for ZFP64 Gene

Protein Domains for ZFP64 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NPA5

UniProtKB/Swiss-Prot:

ZF64B_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFP64: view

Function for ZFP64 Gene

Molecular function for ZFP64 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZFP64: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP64 Gene

Localization for ZFP64 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP64 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP64 Gene COMPARTMENTS Subcellular localization image for ZFP64 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZFP64 Gene

Pathways & Interactions for ZFP64 Gene

SuperPathways for ZFP64 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFP64 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZFP64 Gene

Drugs & Compounds for ZFP64 Gene

(1) Drugs for ZFP64 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1477
genes like me logo Genes that share compounds with ZFP64: view

Transcripts for ZFP64 Gene

Unigene Clusters for ZFP64 Gene

ZFP64 zinc finger protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP64 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - -
SP9: - - -
SP10: - - - - - - -
SP11: - - -
SP12: - - - - - - - - - - -
SP13:
SP14:
SP15: - - - -
SP16: -
SP17:

ExUns: 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for ZFP64 Gene

GeneLoc Exon Structure for
ZFP64
ECgene alternative splicing isoforms for
ZFP64

Expression for ZFP64 Gene

mRNA expression in normal human tissues for ZFP64 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFP64 Gene

This gene is overexpressed in Lung (41.9), Liver (18.2), and Liver, secretome (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFP64 Gene



SOURCE GeneReport for Unigene cluster for ZFP64 Gene Hs.473082

genes like me logo Genes that share expression patterns with ZFP64: view

Protein tissue co-expression partners for ZFP64 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFP64 Gene

Orthologs for ZFP64 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFP64 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP64 35
  • 99.41 (n)
  • 99.26 (a)
ZFP64 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFP64 36
  • 89 (a)
OneToOne
ZFP64 35
  • 87.12 (n)
  • 89.23 (a)
dog
(Canis familiaris)
Mammalia ZFP64 35
  • 91.36 (n)
  • 95.43 (a)
ZFP64 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp64 16
Zfp64 36
  • 88 (a)
OneToOne
Zfp64 35
  • 85.11 (n)
  • 87.72 (a)
oppossum
(Monodelphis domestica)
Mammalia ZFP64 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFP64 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp64 35
  • 84.76 (n)
  • 88.2 (a)
chicken
(Gallus gallus)
Aves ZFP64 35
  • 73.05 (n)
  • 74.82 (a)
ZFP64 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFP64 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3425 35
zfp64 35
  • 62.07 (n)
  • 56.9 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7584 35
zebrafish
(Danio rerio)
Actinopterygii zfp64 36
  • 43 (a)
OneToOne
zfp64 35
  • 57.27 (n)
  • 51.06 (a)
Species with no ortholog for ZFP64:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFP64 Gene

ENSEMBL:
Gene Tree for ZFP64 (if available)
TreeFam:
Gene Tree for ZFP64 (if available)

Paralogs for ZFP64 Gene

Paralogs for ZFP64 Gene

(359) SIMAP similar genes for ZFP64 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZFP64 Gene

genes like me logo Genes that share paralogs with ZFP64: view

Variants for ZFP64 Gene

Sequence variations from dbSNP and Humsavar for ZFP64 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs7353222 - 52,186,915(+) CAAAC(C/G/T)GGACC reference, missense, utr-variant-5-prime
VAR_028020 -
rs16996517 - 52,152,918(+) AGTGG(A/G/T)AACTC intron-variant, reference, missense
rs3746414 - 52,152,840(-) GTACA(A/G)TGAGA intron-variant, reference, missense
VAR_035564 A breast cancer sample

Structural Variations from Database of Genomic Variants (DGV) for ZFP64 Gene

Variant ID Type Subtype PubMed ID
nsv912928 CNV Gain 21882294
esv999399 CNV Insertion 20482838
esv995025 CNV Deletion 20482838
esv2532221 CNV Deletion 19546169
esv2065897 CNV Deletion 18987734
esv2722522 CNV Deletion 23290073
esv2676181 CNV Deletion 23128226
nsv179098 CNV Loss 16902084
esv24606 CNV Loss 19812545
esv1009237 CNV Loss 20482838
nsv514942 CNV Loss 21397061
esv32674 CNV Gain 17666407
esv3942 CNV Deletion 18987735
nsv179831 CNV Loss 16902084
esv2670525 CNV Deletion 23128226

Variation tolerance for ZFP64 Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP64 Gene

HapMap Linkage Disequilibrium report
ZFP64

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP64 Gene

Disorders for ZFP64 Gene

Relevant External Links for ZFP64

Genetic Association Database (GAD)
ZFP64
Human Genome Epidemiology (HuGE) Navigator
ZFP64
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP64

No disorders were found for ZFP64 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP64 Gene

Publications for ZFP64 Gene

  1. Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. (PMID: 17362836) Schymick J.C. … Traynor B.J. (Lancet Neurol 2007) 3 48 67
  2. A search for a mammalian homologue of the Drosophila photoreceptor development gene glass yields Zfp64, a zinc finger encoding gene which maps to the distal end of mouse chromosome 2. (PMID: 9034307) Mack H.G. … Bowtell D.D. (Gene 1997) 2 3
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3

Products for ZFP64 Gene

Sources for ZFP64 Gene

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