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Aliases for ZFP62 Gene

Aliases for ZFP62 Gene

  • ZFP62 Zinc Finger Protein 2 3 5
  • Zfp-62 3 4
  • Zinc Finger Protein 62 Homolog (Mouse) 2
  • Zinc Finger Protein 62 Homolog 3
  • Zinc Finger Protein 62 2
  • ZNF755 3
  • ZET 3

External Ids for ZFP62 Gene

Previous GeneCards Identifiers for ZFP62 Gene

  • GC05M180338
  • GC05M180385
  • GC05M9A0012
  • GC05M9B0012
  • GC05M180209
  • GC05M180274
  • GC05M174999

Summaries for ZFP62 Gene

GeneCards Summary for ZFP62 Gene

ZFP62 (ZFP62 Zinc Finger Protein) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF729.

UniProtKB/Swiss-Prot for ZFP62 Gene

  • May play a role in differentiating skeletal muscle.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP62 Gene

Genomics for ZFP62 Gene

Regulatory Elements for ZFP62 Gene

Enhancers for ZFP62 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F181240 1.2 ENCODE 72.2 -383.9 -383913 9.0 CREB3L1 DMAP1 YBX1 YY1 ZNF143 ZNF548 ZNF263 MCM3 SP3 ZNF610 ENSG00000233937 ZFP62 TRIM52-AS1 RACK1 TRIM52 SNORD96A CNOT6 GFPT2 GC05M181244 GC05M181247
GH05F180669 1 Ensembl 58 +191.2 191190 1.7 HDGF PKNOX1 ZNF133 ARID4B YBX1 ZNF2 GATA2 ZNF143 ZNF207 KLF7 ZFP62 ENSG00000233937 MAML1 TRIM52 LOC100996419 CNOT6 GFPT2 TBC1D9B RN7SKP150 RACK1
GH05F180069 1.5 FANTOM5 ENCODE 34.1 +790.3 790307 3.6 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 KLF13 ZFP62 RNF130 MAML1 CNOT6 LOC105377763 SQSTM1 HNRNPH1 GC05M180018
GH05F180859 1.1 ENCODE 44.7 +0.3 280 2.3 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 KLF13 SP3 ZFP62 ENSG00000233937 TRIM52 GFPT2 CNOT6 SNORD96A LINC00847 GC05P180932
GH05F181215 1.4 Ensembl ENCODE 28.7 -356.4 -356449 3.7 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ENSG00000233937 TRIM52-AS1 ZFP62 RACK1 SNORD96A TRIM7 TRIM52 ENSG00000248367 CNOT6 TRV-AAC1-4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFP62 on UCSC Golden Path with GeneCards custom track

Promoters for ZFP62 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001298549 186 2200 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 KLF13 SP3

Genomic Location for ZFP62 Gene

Chromosome:
5
Start:
180,845,338 bp from pter
End:
180,861,286 bp from pter
Size:
15,949 bases
Orientation:
Minus strand

Genomic View for ZFP62 Gene

Genes around ZFP62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP62 Gene

Proteins for ZFP62 Gene

  • Protein details for ZFP62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NB50-ZFP62_HUMAN
    Recommended name:
    Zinc finger protein 62 homolog
    Protein Accession:
    Q8NB50
    Secondary Accessions:
    • B4DIP6
    • B4E0N3
    • B5MDX6
    • B7ZVZ2
    • B9EIP6
    • E9PFT8
    • J3QTA9

    Protein attributes for ZFP62 Gene

    Size:
    900 amino acids
    Molecular mass:
    102511 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI40762.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC03691.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG58558.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical GTG valine codon.; Evidence={ECO:0000305}; Sequence=CAI46133.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFP62 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP62 Gene

Post-translational modifications for ZFP62 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFP62 Gene

Domains & Families for ZFP62 Gene

Gene Families for ZFP62 Gene

Protein Domains for ZFP62 Gene

Suggested Antigen Peptide Sequences for ZFP62 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NB50

UniProtKB/Swiss-Prot:

ZFP62_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 23 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 23 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFP62: view

Function for ZFP62 Gene

Molecular function for ZFP62 Gene

UniProtKB/Swiss-Prot Function:
May play a role in differentiating skeletal muscle.

Gene Ontology (GO) - Molecular Function for ZFP62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP62: view
genes like me logo Genes that share phenotypes with ZFP62: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP62 Gene

Localization for ZFP62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP62 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP62 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ZFP62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP62: view

Pathways & Interactions for ZFP62 Gene

SuperPathways for ZFP62 Gene

No Data Available

Interacting Proteins for ZFP62 Gene

Gene Ontology (GO) - Biological Process for ZFP62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZFP62: view

No data available for Pathways by source and SIGNOR curated interactions for ZFP62 Gene

Transcripts for ZFP62 Gene

mRNA/cDNA for ZFP62 Gene

(14) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP62 Gene

ZFP62 zinc finger protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP62 Gene

No ASD Table

Relevant External Links for ZFP62 Gene

GeneLoc Exon Structure for
ZFP62
ECgene alternative splicing isoforms for
ZFP62

Expression for ZFP62 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFP62 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFP62 Gene



Protein tissue co-expression partners for ZFP62 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFP62 Gene:

ZFP62

SOURCE GeneReport for Unigene cluster for ZFP62 Gene:

Hs.509227
genes like me logo Genes that share expression patterns with ZFP62: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFP62 Gene

Orthologs for ZFP62 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP62 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP62 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia ZFP62 34 35
  • 91.48 (n)
cow
(Bos Taurus)
Mammalia ZFP62 34 35
  • 91.3 (n)
rat
(Rattus norvegicus)
Mammalia RGD1560191 34
  • 87.98 (n)
mouse
(Mus musculus)
Mammalia Zfp62 34 16 35
  • 87.47 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 53 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 53 (a)
OneToMany
Species where no ortholog for ZFP62 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP62 Gene

ENSEMBL:
Gene Tree for ZFP62 (if available)
TreeFam:
Gene Tree for ZFP62 (if available)

Paralogs for ZFP62 Gene

(527) SIMAP similar genes for ZFP62 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZFP62: view

Variants for ZFP62 Gene

Sequence variations from dbSNP and Humsavar for ZFP62 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000015 -- 180,849,788(-) AAAGC(A/G)TACAT reference, synonymous-codon
rs111718993 -- 180,845,340(+) AAAAA(A/G)AAAAA downstream-variant-500B, utr-variant-3-prime
rs111743384 -- 180,860,689(+) CGACC(-/A/AA/AAA)AAAAA intron-variant, upstream-variant-2KB
rs111890266 -- 180,852,598(+) CTTCA(C/T)ACCAT intron-variant
rs111918759 -- 180,853,683(+) TTAGA(A/G)ACGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP62 Gene

Variant ID Type Subtype PubMed ID
dgv9n29 CNV loss 16826518
esv2759399 CNV gain 17122850
nsv1026417 CNV gain 25217958
nsv1161322 CNV duplication 26073780
nsv428133 CNV gain 18775914
nsv820020 CNV loss 19587683
nsv830566 CNV loss 17160897

Variation tolerance for ZFP62 Gene

Gene Damage Index Score: 2.94; 49.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP62 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP62

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP62 Gene

Disorders for ZFP62 Gene

Relevant External Links for ZFP62

Genetic Association Database (GAD)
ZFP62
Human Genome Epidemiology (HuGE) Navigator
ZFP62
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP62

No disorders were found for ZFP62 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP62 Gene

Publications for ZFP62 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Differentiation dependent expression in muscle cells of ZT3, a novel zinc finger factor differentially expressed in embryonic and adult tissues. (PMID: 8808410) Polimeni M. … BouchAc M. (Mech. Dev. 1996) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 64

Products for ZFP62 Gene

Sources for ZFP62 Gene

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