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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFP62 Gene

protein-coding   GIFtS: 44
GCID: GC05M180274

ZFP62 zinc finger protein

(Previous names: zinc finger protein 62 homolog (mouse), zinc finger protein...)
 Explore 1 disease affiliated with
ZFP62 via our new
 Human Malady Compendium 
Biological research products
for ZFP62
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ZFP62 Zinc Finger Protein1 2     Zinc Finger Protein 62 Homolog (Mouse)1
ZET1 2     Zfp-623
ZNF7551 2     Zinc Finger Protein 62 Homolog2
FLJ342311     Zfp-623
Zinc Finger Protein 621     

External Ids:    HGNC: 232411   Entrez Gene: 6438362   Ensembl: ENSG000001966707   OMIM: 6102815   UniProtKB: Q8NB503   

Export aliases for ZFP62 gene to outside databases

Previous GC identifers: GC05M180338 GC05M180385 GC05M9A0012 GC05M9B0012 GC05M180209 GC05M174999


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZFP62_HUMAN, Q8NB50
Function: May play a role in differentiating skeletal muscle (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFP62 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   NF-kappaB   POU2F2   POU2F1   POU2F1a   Chx10   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZFP62

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP62


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

ZFP62 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP62 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M180274:  view genomic region     (about GC identifiers)

Start:
180,274,611 bp from pter      End:
180,288,286 bp from pter
Size:
13,676 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZFP62_HUMAN, Q8NB50 (See protein sequence)
Recommended Name: Zinc finger protein 62 homolog  
Size: 900 amino acids; 102511 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAI40762.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC03691.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG58558.1;
Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical GTG
valine codon; Sequence=CAI46133.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DIP6 B4E0N3 B5MDX6 B7ZVZ2 B9EIP6 E9PFT8 J3QTA9
Alternative splicing: 3 isoforms:  Q8NB50-1   Q8NB50-2   Q8NB50-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFP62: NX_Q8NB50

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NB50

  • ZFP62 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001166109.1  NP_689496.4  

    ENSEMBL proteins: 
     ENSP00000426193   ENSP00000423820   ENSP00000422987   ENSP00000423709   ENSP00000424156  
     ENSP00000352053  

    Human Recombinant Protein Products: 
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    Uscn Proteins for ZFP62

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--


    ZFP62 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZFP62 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8NB50

    ProtoNet protein and cluster: Q8NB50

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZFP62_HUMAN, Q8NB50
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 23 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZFP62_HUMAN, Q8NB50
    Function: May play a role in differentiating skeletal muscle (By similarity)

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP62

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding IEA--


    ZFP62 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFP62

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    ZFP62 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFP62
    Search CenterWatch for drugs/clinical trials and news about ZFP62 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFP62 gene (2 alternative transcripts): 
    NM_001172638.1  NM_152283.4  

    Unigene Cluster for ZFP62:

    ZFP62 zinc finger protein
    Hs.509227  [show with all ESTs]
    Unigene Representative Sequence: AL832408
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506377(uc003mmm.4) ENST00000512132 ENST00000507843 ENST00000502412
    ENST00000504225 ENST00000506439 ENST00000509066 ENST00000359141(uc011dhe.2 uc011dhf.2 uc010jlk.3)


    miRNA
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    OriGene 3'-UTR Clone: ZFP62
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFP62
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFP62 (see all 16):
    hsa-miR-3938 hsa-miR-125a-5p hsa-miR-181c hsa-miR-181a-2* hsa-miR-1257 hsa-miR-125b hsa-miR-181b hsa-miR-18a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFP62 (see all 4)
    OriGene shRNA RFP: ZFP62
    OriGene siRNA: ZFP62
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFP62
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFP62
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP62

    Additional cDNA sequence: 

    AK002206.1 AK091376.1 AK091550.1 AK295714.1 AK303450.1 AL832408.1 BC029573.1 BC140761.1 
    BC171780.1 

    6 DOTS entries:

    DT.75162574  DT.210900  DT.100000778  DT.120883399  DT.120883394  DT.120883390 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFP62 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAGCCAGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ZFP62 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZFP62 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFP62

    SOURCE GeneReport for Unigene cluster: Hs.509227
        SABiosciences Custom PCR Arrays for ZFP62
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP62

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZFP62 gene from 3/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01028403.26
    BX936350.26
    (see all 96)
    --
    55(a)
    52(a)
    (see all 96)
    possible ortholog
    possible ortholog
    (see all 96)
    4(29566845-29568897)
    4(45647359-45649074)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79876
    CG312246
    (see all 10)
    --
    9(a)
    7(a)
    (see all 10)
    possible ortholog
    possible ortholog
    (see all 10)
    3R(10396194-10401570)
    3R(14475843-14484963)
    worm
    (Caenorhabditis elegans)
    Secernentea Y55F3AM.146
    Y48G8AL.106
    (see all 3)
    --
    16(a)
    13(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    IV(1058845-1063187)
    I(1142033-1154389)


    ENSEMBL Gene Tree for ZFP62 (if available)
    TreeFam Gene Tree for ZFP62 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/291 NCBI SNPs in ZFP62 are shown (see all 291    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127852981,2
    --180274250(+) GAAGAG/ATCTAT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs171412051,2
    C,F,H,--180274253(+) GAGTCT/AATTTT 2 -- int117Minor allele frequency- A:0.10NA NS EA CSA 2028
    rs782457581,2
    C--180274376(+) CTCCCCT/-GAGTT 2 -- int12Minor allele frequency- -:0.00CSA 4
    rs2493151,2
    C,F,O,A,H,--180274402(-) TGATCG/CTCGTT 2 -- int122Minor allele frequency- C:0.41NS EA NA CSA 2531
    rs1440930401,2
    --180274525(+) CCCTCG/TCTGGT 2 -- int10--------
    rs2493141,2
    C,F,O,A,H,--180274553(+) TACCCC/AACAAA 2 -- int118Minor allele frequency- A:0.34NS EA NA CSA WA 2221
    rs2493131,2
    C,A,--180274565(+) ATCTGG/ACACAC 2 -- int16Minor allele frequency- A:0.43NA CSA WA 245
    rs170806951,2
    C,F,H,--180274654(+) ACCTCG/ACCACA 2 -- ut3114Minor allele frequency- A:0.08NA NS EA CSA 1419
    rs1487451911,2
    --180275075(+) AGTTCA/GTCTGA 2 -- ut310--------
    rs754473831,2
    C--180275111(+) AACTAA/GTGTAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ZFP62 (180274611 - 180288286 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for ZFP62
         4 CNVs: 3592 2094 2093 59254

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZFP62 for disorders           About GeneDecksing

    OMIM gene information: 610281    OMIM disorders: --

    1 disease for ZFP62:    About MalaCards
    oligohydramnios

    Human Genome Epidemiology (HuGE) Navigator: ZFP62 (1 document)

    Export disorders for ZFP62 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFP62 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ZFP62)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Differentiation dependent expression in muscle cells of ZT3, a novel zinc finger factor differentially expressed in embryonic and adult tissues. (PubMed id 8808410)1, 3 Polimeni M....Bouche M. (1996)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PubMed id 17924679)1 Yu L.-R.... Veenstra T.D. (2007)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    10. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 643836 HGNC: 23241 Ensembl:ENSG00000196670 euGenes: HUgn643836 ECgene: ZFP62
    H-InvDB: ZFP62

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFP62 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFP62 gene:
    Search GeneIP for patents involving ZFP62

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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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