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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFP42 Gene

protein-coding   GIFtS: 55
GCID: GC04P188916

ZFP42 zinc finger protein

(Previous names: zinc finger protein 42 homolog (mouse), zinc finger protein...)
 Explore 10 diseases affiliated with
ZFP42 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZFP42    

Aliases
for ZFP42 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ZFP42 Zinc Finger Protein1 2     Zinc Finger Protein 421
REX11 2 3     Zinc Finger Protein 42 Homolog (Mouse)1
ZNF7541 2 3     REX1 Transcription Factor2
Reduced Expression Protein 12 3     Zfp-423
Zinc Finger Protein 7542 3     Zinc Finger Protein 42 Homolog2
REX-12 3     Zfp-423
HREX-11     

External Ids:    HGNC: 309491   Entrez Gene: 1326252   Ensembl: ENSG000001790597   OMIM: 6145725   UniProtKB: Q96MM33   

Export aliases for ZFP42 gene to outside databases

Previous GC identifers: GC04P189596 GC04P189612 GC04P189292 GC04P189153 GC04P184653


Summaries
for ZFP42 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ZFP42_HUMAN, Q96MM3
Function: Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required
for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter.
Involved in ES cell self-renewal (By similarity)

Gene Wiki entry for ZFP42


Genomic Views
for ZFP42 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFP42 gene promoter:
         SRF   Gfi-1   MEF-2A   Max   Nkx6-1   POU2F1   POU2F1a   aMEF-2   Ik-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZFP42 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFP42

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.2   Ensembl cytogenetic band:  4q35.2   HGNC cytogenetic band: 4q35.2

ZFP42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP42 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P188916:  view genomic region     (about GC identifiers)

Start:
 188,916,925 bp from pter      End:
 188,926,204 bp from pter
Size:
 9,280 bases      Orientation:
 plus strand

Proteins
for ZFP42 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZFP42_HUMAN, Q96MM3 (See protein sequence)
Recommended Name: Zinc finger protein 42 homolog  
Size: 310 amino acids; 34802 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: D3DP65 Q8WXE2

Explore the universe of human proteins at neXtProt for ZFP42: NX_Q96MM3

Post-translational modifications:

  • Polyubiquitinated by RNF12, leading to proteasomal degradation (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96MM3

    • ZFP42 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_777560.2  
    ENSEMBL proteins: 
     ENSP00000317686   ENSP00000424662  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: ZFP42
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    Novus Biologicals ZFP42 Protein
    Novus Biologicals ZFP42 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZFP42

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA18281244


    ZFP42 for ontologies           About GeneDecksing



    ZFP42 Antibody Products: 
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    Uscn ELISAs and CLIAs for ZFP42

    Protein Domains /
    Families
    for ZFP42 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZFP42 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96MM3

    ProtoNet protein and cluster: Q96MM3

    UniProtKB/Swiss-Prot: ZFP42_HUMAN, Q96MM3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers


    Function
    for ZFP42 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZFP42_HUMAN, Q96MM3
    Function: Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required
    for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter.
    Involved in ES cell self-renewal (By similarity)
    Induction: Down-regulated upon retinoic acid addition to F9 stem cells

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFP42
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFP42:
    hsa-miR-3671 hsa-miR-569 hsa-miR-3140-3p hsa-miR-16-2* hsa-miR-195* hsa-miR-802
    SwitchGear 3'UTR luciferase reporter plasmid: ZFP42 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFP42 (see all 4)
    OriGene shRNA RFP: ZFP42
    OriGene siRNA: ZFP42
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFP42

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ZFP42

    Clone
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    GenScript: all cDNA clones in your preferred vector: ZFP42 (NM_174900)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFP42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP42 

    Cell Line
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    Search LifeMap BioReagents cell lines for ZFP42

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP42

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS14688391
    GO:0008270zinc ion binding IEA--


    ZFP42 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZFP42:
     Increased 8N DNA content 

    Animal Models:
         Mouse knock-out Zfp42tm1.1Log for ZFP42
         5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Zfp42):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  reproductive system 

    ZFP42 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ZFP42 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFP42

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/19 Interacting proteins for ZFP42 (Q96MM33 ENSP000003176864) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF2Q994963, ENSP000003564804I2D: score=2 STRING: ENSP00000356480
    DPF2Q927853I2D: score=2 
    NACC1Q96RE73I2D: score=2 
    POU5F1Q018603I2D: score=2 
    PRMT1Q998733I2D: score=2 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007126meiosis NAS18281244
    GO:0007286spermatid development IEA--


    ZFP42 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZFP42 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZFP42 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFP42
    1 Novoseek chemical compound relationship for ZFP42 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 12.6 7 16865673 (3), 16344273 (1)

    Search CenterWatch for drugs/clinical trials and news about ZFP42 

    Transcripts
    for ZFP42 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZFP42 gene: 
    NM_174900.3  

    Unigene Cluster for ZFP42:

    ZFP42 zinc finger protein
    Hs.335787  [show with all ESTs]
    Unigene Representative Sequence: AY429593
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326866(uc003izh.1) ENST00000509524(uc003izi.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFP42
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFP42:
    hsa-miR-3671 hsa-miR-569 hsa-miR-3140-3p hsa-miR-16-2* hsa-miR-195* hsa-miR-802
    SwitchGear 3'UTR luciferase reporter plasmid: ZFP42 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFP42 (see all 4)
    OriGene shRNA RFP: ZFP42
    OriGene siRNA: ZFP42
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFP42
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP42
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    GenScript: all cDNA clones in your preferred vector: ZFP42 (NM_174900)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFP42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP42 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFP42
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFP42
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP42

    Additional cDNA sequence: 

    AF450454.1 AK056719.1 AY429593.1 

    3 DOTS entries:

    DT.99993904  DT.95260486  DT.40123233 

    20 AceView cDNA sequences:

    AW673744 AF450454 BX336340 AW665472 AA906796 CR624529 BX369177 BE301754 
    BX369178 AY429593 AA738254 NM_174900 BX103592 N32798 AK056719 BI092935 
    BX336339 N42241 AW673107 AA641545 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZFP42    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
    SP1:                                                
    SP2:                    -                           
    SP3:                    -                           


    ECgene alternative splicing isoforms for ZFP42

    Expression
    for ZFP42 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFP42 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCATAGCCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZFP42 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EpiblastEpiblastEarly Epiblast CellsEarly Embryo
    Inner Cell MassInner Cell MassInner Cell Mass CellsEarly Embryo
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/28 LifeMap Cells (see all 28) 
    NameCategory
    Induced pluripotent stem cell line 20D17 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line 178B5 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line 492B4 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cells (ALS patient) (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    BG01V (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    CyT203 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    VUB02 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    VUB03_DM1 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    VUB04_CF (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See ZFP42 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFP42

    SOURCE GeneReport for Unigene cluster: Hs.335787

    UniProtKB/Swiss-Prot: ZFP42_HUMAN, Q96MM3
    Tissue specificity: Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway
    lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein
    level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and
    small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several
    carcinoma cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including ZFP42: 
              Cell Lineage Identification in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP42

    Orthologs
    for ZFP42 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZFP42 gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zfp421 , 5 zinc finger protein 421, 5 66.31(n)1
    58.21(a)1    		   8 (23.89 cM)5
    227021  NM_009556.31  NP_033582.21 
     432950685 
    chicken
    (Gallus gallus)    		 Aves YY16
    		 YY1 transcription factor
    		 67(a)
    		 possible ortholog
    		 5(51008399-51021542)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 69(a)
    		 possible ortholog
    		 GL343270.1(988957-993664)
    zebrafish
    (Danio rerio)    		 Actinopterygii yy1b6
    yy1a6
    		 YY1 transcription factor a
    		 40(a)
    39(a)
    		 possible ortholog
    possible ortholog
    		 20(54760884-54773885)
    17(30916118-30922362)
    fruit fly
    (Drosophila melanogaster)    		 Insecta pho6
    phol6
    		 pleiohomeotic like
    		 22(a)
    15(a)
    		 possible ortholog
    possible ortholog
    		 4(1193094-1202271)
    3L(9446148-9449381)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G066346
    		 uncharacterized zinc finger protein
    		 17(a)
    		 1 → many
    		 4(3764289-3766578)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 ZOS5-01 - C2H2 zinc finger protein, expressed
    		 18(a)
    15(a)
    		 many ↔ many
    many ↔ many
    		 2(20795085-20798606)
    5(321102-324421)


    ENSEMBL Gene Tree for ZFP42 (if available)
    TreeFam Gene Tree for ZFP42 (if available) 

    Paralogs
    for ZFP42 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFP42 gene
    ZNF762  GLI12  ZIC22  YY12  ZIC12  GLIS22  GLI22  ZNF1432  
    GLI32  YY22  MTF12  ZIC32  ZNF4102  GLIS12  ZIC42  GLIS32  
    ZIC52  
    2 SIMAP similar genes for ZFP42 using alignment to 1 protein entry:     ZFP42_HUMAN:
    YY2    YY1

    ZFP42 for paralogs           About GeneDecksing



    Genomic Variants
    for ZFP42 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for ZFP42
         5 CNVs: 8468 51353 32679 7437 34439
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFP42
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFP42

    Disorders / Diseases
    for ZFP42 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZFP42 for disorders           About GeneDecksing

    OMIM gene information: 614572    OMIM disorders: --

    10 diseases for ZFP42:    About MalaCards
    male germ cell tumor    germ cell tumor    chromophobe adenocarcinoma    renal cell carcinoma
    embryonal carcinoma    teratocarcinoma    seminoma    carcinoma
    prostate cancer    prostatitis

    3 diseases from the University of Copenhagen DISEASES database for ZFP42:
    Teratocarcinoma     Chromophobe adenocarcinoma     Embryonal carcinoma

    2 Novoseek disease relationships for ZFP42 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 8 16344273 (6)
    carcinoma 0 3 16865673 (1), 16344273 (1)

    Human Genome Epidemiology (HuGE) Navigator: ZFP42 (1 document)

    Export disorders for ZFP42 gene to outside databases

    Publications
    for ZFP42 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFP42 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with ZFP42)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens. (PubMed id 12110702)1, 2, 3 Henderson J.K.... Andrews P.W. (2002)
    2. Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma. (PubMed id 16344273)1, 2, 9 Raman J.D....Gudas L.J. (2006)
    3. The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures. (PubMed id 16865673)1, 2, 9 Mongan N.P.... Gudas L.J. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Transcriptional regulation of Rex1 (zfp42) in normal prostate epithelial cells and prostate cancer cells. (PubMed id 20232320)1, 9 Lee M.Y....Gudas L.J. (2010)
    6. Association of Rex-1 to target genes supports its inte raction with Polycomb function. (PubMed id 21530438)1 Garcia-Tunon I....Schoorlemmer J. (2011)
    7. Embryonic stem cell factors undifferentiated transcri ption factor-1 (UFT-1) and reduced expression protein-1 (REX-1) are widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination. (PubMed id 21446939)1 Reinisch C.M....Pammer J. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. (PubMed id 18281244)1 Kristensen D.M....Leffers H. (2008)
    10. Oct-4, Rex-1, and Gata-4 expression in human MSC increase the differentiation efficiency but not hTERT expression. (PubMed id 17211834)1 Roche S....Favrot M.C. (2007)

    External Searches for ZFP42 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ZFP42 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 132625 HGNC: 30949 AceView: ZFP42 Ensembl:ENSG00000179059 euGenes: HUgn132625
    ECgene: ZFP42 H-InvDB: ZFP42

    Other Databases showing ZFP42 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZFP42 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFP42 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZFP42 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZFP42 gene:
    Search GeneIP for patents involving ZFP42

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