Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZFP42 Gene

Aliases for ZFP42 Gene

  • ZFP42 Zinc Finger Protein 2 3
  • REX1 3 4 6
  • Reduced Expression Protein 1 3 4
  • Zinc Finger Protein 754 3 4
  • Zfp-42 3 4
  • ZNF754 3 4
  • REX-1 3 4
  • Zinc Finger Protein 42 Homolog (Mouse) 2
  • Zinc Finger Protein 42 Homolog 3
  • REX1 Transcription Factor 3
  • Zinc Finger Protein 42 2
  • HREX-1 4

External Ids for ZFP42 Gene

Previous GeneCards Identifiers for ZFP42 Gene

  • GC04P189596
  • GC04P189612
  • GC04P189292
  • GC04P189153
  • GC04P188916
  • GC04P184653

Summaries for ZFP42 Gene

GeneCards Summary for ZFP42 Gene

ZFP42 (ZFP42 Zinc Finger Protein) is a Protein Coding gene. Diseases associated with ZFP42 include chromophobe adenocarcinoma. Among its related pathways are Cardiac Progenitor Differentiation. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF853.

UniProtKB/Swiss-Prot for ZFP42 Gene

  • Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity).

Gene Wiki entry for ZFP42 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP42 Gene

Genomics for ZFP42 Gene

Regulatory Elements for ZFP42 Gene

Genomic Location for ZFP42 Gene

Start:
187,995,771 bp from pter
End:
188,005,050 bp from pter
Size:
9,280 bases
Orientation:
Plus strand

Genomic View for ZFP42 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFP42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP42 Gene

Proteins for ZFP42 Gene

  • Protein details for ZFP42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MM3-ZFP42_HUMAN
    Recommended name:
    Zinc finger protein 42 homolog
    Protein Accession:
    Q96MM3
    Secondary Accessions:
    • D3DP65
    • Q8WXE2

    Protein attributes for ZFP42 Gene

    Size:
    310 amino acids
    Molecular mass:
    34802 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZFP42 Gene

Proteomics data for ZFP42 Gene at MOPED

Post-translational modifications for ZFP42 Gene

  • Polyubiquitinated by RNF12, leading to proteasomal degradation.
  • Ubiquitination at Lys231 and Lys233
  • Modification sites at PhosphoSitePlus

Other Protein References for ZFP42 Gene

No data available for DME Specific Peptides for ZFP42 Gene

Domains for ZFP42 Gene

Gene Families for ZFP42 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZFP42 Gene

Suggested Antigen Peptide Sequences for ZFP42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MM3

UniProtKB/Swiss-Prot:

ZFP42_HUMAN :
  • Q96MM3
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFP42: view

Function for ZFP42 Gene

Molecular function for ZFP42 Gene

UniProtKB/Swiss-Prot Function: Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity).
UniProtKB/Swiss-Prot Induction: Down-regulated upon retinoic acid addition to F9 stem cells.

Gene Ontology (GO) - Molecular Function for ZFP42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 14688391
GO:0005515 protein binding --
GO:0043565 sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP42: view

Phenotypes for ZFP42 Gene

genes like me logo Genes that share phenotypes with ZFP42: view

Animal Models for ZFP42 Gene

MGI Knock Outs for ZFP42:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ZFP42 Gene

Localization for ZFP42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP42 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP42 Gene COMPARTMENTS Subcellular localization image for ZFP42 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZFP42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 16344273
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with ZFP42: view

Pathways for ZFP42 Gene

genes like me logo Genes that share pathways with ZFP42: view

Pathways by source for ZFP42 Gene

1 BioSystems pathway for ZFP42 Gene

Gene Ontology (GO) - Biological Process for ZFP42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007126 meiotic nuclear division NAS 18281244
GO:0007286 spermatid development IEA --
genes like me logo Genes that share ontologies with ZFP42: view

Compounds for ZFP42 Gene

(1) Novoseek inferred chemical compound relationships for ZFP42 Gene

Compound -log(P) Hits PubMed IDs
zinc 12.6 4
genes like me logo Genes that share compounds with ZFP42: view

Transcripts for ZFP42 Gene

mRNA/cDNA for ZFP42 Gene

Unigene Clusters for ZFP42 Gene

ZFP42 zinc finger protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP42 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1:
SP2: -
SP3: -

Relevant External Links for ZFP42 Gene

GeneLoc Exon Structure for
ZFP42
ECgene alternative splicing isoforms for
ZFP42

Expression for ZFP42 Gene

mRNA expression in normal human tissues for ZFP42 Gene

mRNA differential expression in normal tissues according to GTEx for ZFP42 Gene

This gene is overexpressed in Testis (44.6).

SOURCE GeneReport for Unigene cluster for ZFP42 Gene Hs.335787

mRNA Expression by UniProt/SwissProt for ZFP42 Gene

Q96MM3-ZFP42_HUMAN
Tissue specificity: Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines.
genes like me logo Genes that share expressions with ZFP42: view

No data available for Protein expression for ZFP42 Gene

Orthologs for ZFP42 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFP42 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP42 35
  • 98.92 (n)
  • 98.06 (a)
ZFP42 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFP42 35
  • 75.51 (n)
  • 64.97 (a)
ZFP42 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP42 35
  • 78.48 (n)
  • 68.87 (a)
ZFP42 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp42 35
  • 66.31 (n)
  • 58.21 (a)
Zfp42 16
Zfp42 36
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp42 35
  • 67.91 (n)
  • 59.52 (a)
chicken
(Gallus gallus)
Aves YY1 36
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii yy1a 36
  • 41 (a)
ManyToMany
yy1b 36
  • 39 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta pho 36
  • 20 (a)
ManyToMany
phol 36
  • 16 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for ZFP42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFP42 Gene

ENSEMBL:
Gene Tree for ZFP42 (if available)
TreeFam:
Gene Tree for ZFP42 (if available)

Paralogs for ZFP42 Gene

Paralogs for ZFP42 Gene

Selected SIMAP similar genes for ZFP42 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZFP42: view

Variants for ZFP42 Gene

Sequence variations from dbSNP and Humsavar for ZFP42 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1565656 -- 188,001,391(-) AACAT(C/T)TAACA intron-variant
rs1565657 -- 187,999,496(+) TCTAC(A/G)TTAAA intron-variant
rs4862848 -- 188,000,286(+) AGAGC(A/G)GCTCT intron-variant
rs6553123 -- 187,996,404(+) CTCCC(A/G)GGTTC intron-variant
rs6815391 -- 188,003,825(+) AATTT(C/T)TAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZFP42 Gene

Variant ID Type Subtype PubMed ID
dgv5855n71 CNV Gain 21882294
nsv523635 CNV Gain 19592680
esv32613 CNV Gain 17666407
esv2752041 CNV Gain 17911159
nsv880579 CNV Gain 21882294
nsv880478 CNV Loss 21882294
dgv5860n71 CNV Gain 21882294
nsv880937 CNV Loss 21882294
nsv10629 CNV Loss 18304495
dgv5861n71 CNV Gain 21882294
nsv461870 CNV Gain 19166990
nsv470098 CNV Gain 18288195
nsv880982 CNV Gain 21882294
nsv461871 CNV Gain 19166990
nsv880626 CNV Gain 21882294
nsv881101 CNV Gain 21882294
nsv7367 OTHER Inversion 18451855
dgv332n21 CNV Loss 19592680
nsv880458 CNV Gain 21882294
nsv830173 CNV Gain 17160897
nsv519300 CNV Gain+Loss 19592680

Relevant External Links for ZFP42 Gene

HapMap Linkage Disequilibrium report
ZFP42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP42 Gene

Disorders for ZFP42 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZFP42 Gene including...

Search for ZFP42 Gene in MalaCards »

(3) University of Copenhagen DISEASES for ZFP42 Gene

(2) Novoseek inferred disease relationships for ZFP42 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 6
carcinoma 0 2

Relevant External Links for ZFP42

Human Genome Epidemiology (HuGE) Navigator
ZFP42
genes like me logo Genes that share disorders with ZFP42: view

No data available for UniProtKB/Swiss-Prot for ZFP42 Gene

Publications for ZFP42 Gene

  1. Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma. (PMID: 16344273) Raman J.D. … Gudas L.J. (Carcinogenesis 2006) 3 4 23
  2. The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures. (PMID: 16865673) Mongan N.P. … Gudas L.J. (Mol. Carcinog. 2006) 3 4 23
  3. Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens. (PMID: 12110702) Henderson J.K. … Andrews P.W. (Stem Cells 2002) 2 3 4
  4. Transcriptional regulation of Rex1 (zfp42) in normal prostate epithelial cells and prostate cancer cells. (PMID: 20232320) Lee M.Y. … Gudas L.J. (J. Cell. Physiol. 2010) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ZFP42 Gene

Sources for ZFP42 Gene

Back to Top

Content