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Aliases for ZFP42 Gene

Aliases for ZFP42 Gene

  • ZFP42 Zinc Finger Protein 2 3 5
  • Reduced Expression Protein 1 3 4
  • Zinc Finger Protein 754 3 4
  • Zfp-42 3 4
  • ZNF754 3 4
  • REX-1 3 4
  • REX1 3 4
  • Zinc Finger Protein 42 Homolog (Mouse) 2
  • REX1 Transcription Factor 3
  • Zinc Finger Protein 42 2
  • HREX-1 4

External Ids for ZFP42 Gene

Previous GeneCards Identifiers for ZFP42 Gene

  • GC04P189596
  • GC04P189612
  • GC04P189292
  • GC04P189153
  • GC04P188916
  • GC04P184653

Summaries for ZFP42 Gene

GeneCards Summary for ZFP42 Gene

ZFP42 (ZFP42 Zinc Finger Protein) is a Protein Coding gene. Diseases associated with ZFP42 include mixed germ cell cancer. Among its related pathways are Cardiac Progenitor Differentiation and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is ZIC3.

UniProtKB/Swiss-Prot for ZFP42 Gene

  • Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity).

Gene Wiki entry for ZFP42 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP42 Gene

Genomics for ZFP42 Gene

Regulatory Elements for ZFP42 Gene

Genomic Location for ZFP42 Gene

Chromosome:
4
Start:
187,994,054 bp from pter
End:
188,005,050 bp from pter
Size:
10,997 bases
Orientation:
Plus strand

Genomic View for ZFP42 Gene

Genes around ZFP42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP42 Gene

Proteins for ZFP42 Gene

  • Protein details for ZFP42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MM3-ZFP42_HUMAN
    Recommended name:
    Zinc finger protein 42 homolog
    Protein Accession:
    Q96MM3
    Secondary Accessions:
    • D3DP65
    • Q8WXE2

    Protein attributes for ZFP42 Gene

    Size:
    310 amino acids
    Molecular mass:
    34802 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZFP42 Gene

Proteomics data for ZFP42 Gene at MOPED

Post-translational modifications for ZFP42 Gene

  • Polyubiquitinated by RNF12, leading to proteasomal degradation.
  • Ubiquitination at Lys 231 and Lys 233
  • Modification sites at PhosphoSitePlus

Other Protein References for ZFP42 Gene

No data available for DME Specific Peptides for ZFP42 Gene

Domains & Families for ZFP42 Gene

Gene Families for ZFP42 Gene

Protein Domains for ZFP42 Gene

Suggested Antigen Peptide Sequences for ZFP42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MM3

UniProtKB/Swiss-Prot:

ZFP42_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFP42: view

Function for ZFP42 Gene

Molecular function for ZFP42 Gene

UniProtKB/Swiss-Prot Function:
Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated upon retinoic acid addition to F9 stem cells.
genes like me logo Genes that share phenotypes with ZFP42: view

Animal Models for ZFP42 Gene

MGI Knock Outs for ZFP42:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZFP42 Gene

Localization for ZFP42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP42 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP42 Gene COMPARTMENTS Subcellular localization image for ZFP42 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZFP42 Gene

Pathways & Interactions for ZFP42 Gene

genes like me logo Genes that share pathways with ZFP42: view

Pathways by source for ZFP42 Gene

Gene Ontology (GO) - Biological Process for ZFP42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008585 female gonad development IEP 18281244
genes like me logo Genes that share ontologies with ZFP42: view

No data available for SIGNOR curated interactions for ZFP42 Gene

Drugs & Compounds for ZFP42 Gene

(1) Drugs for ZFP42 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZFP42: view

Transcripts for ZFP42 Gene

mRNA/cDNA for ZFP42 Gene

Unigene Clusters for ZFP42 Gene

ZFP42 zinc finger protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP42 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1:
SP2: -
SP3: -

Relevant External Links for ZFP42 Gene

GeneLoc Exon Structure for
ZFP42
ECgene alternative splicing isoforms for
ZFP42

Expression for ZFP42 Gene

mRNA expression in normal human tissues for ZFP42 Gene

mRNA differential expression in normal tissues according to GTEx for ZFP42 Gene

This gene is overexpressed in Testis (x44.6).

SOURCE GeneReport for Unigene cluster for ZFP42 Gene Hs.335787

mRNA Expression by UniProt/SwissProt for ZFP42 Gene

Q96MM3-ZFP42_HUMAN
Tissue specificity: Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines.
genes like me logo Genes that share expression patterns with ZFP42: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZFP42 Gene

Orthologs for ZFP42 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFP42 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZFP42 35
  • 75.51 (n)
  • 64.97 (a)
ZFP42 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP42 35
  • 78.48 (n)
  • 68.87 (a)
ZFP42 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp42 35
  • 66.31 (n)
  • 58.21 (a)
Zfp42 16
Zfp42 36
  • 53 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZFP42 35
  • 98.92 (n)
  • 98.06 (a)
ZFP42 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp42 35
  • 67.91 (n)
  • 59.52 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves YY1 36
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii yy1a 36
  • 41 (a)
ManyToMany
yy1b 36
  • 39 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta pho 36
  • 20 (a)
ManyToMany
phol 36
  • 16 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMR3 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for ZFP42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFP42 Gene

ENSEMBL:
Gene Tree for ZFP42 (if available)
TreeFam:
Gene Tree for ZFP42 (if available)

Paralogs for ZFP42 Gene

(2) SIMAP similar genes for ZFP42 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZFP42: view

Variants for ZFP42 Gene

Sequence variations from dbSNP and Humsavar for ZFP42 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1565656 -- 188,001,391(-) AACAT(C/T)TAACA intron-variant
rs1565657 -- 187,999,496(+) TCTAC(A/G)TTAAA intron-variant
rs4862848 -- 188,000,286(+) AGAGC(A/G)GCTCT intron-variant
rs6815391 -- 188,003,825(+) AATTT(C/T)TAAAT utr-variant-3-prime
rs6851368 -- 187,996,471(+) GCGCC(C/G)GGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP42 Gene

Variant ID Type Subtype PubMed ID
dgv5855n71 CNV Gain 21882294
nsv523635 CNV Gain 19592680
esv32613 CNV Gain 17666407
esv2752041 CNV Gain 17911159
nsv880579 CNV Gain 21882294
nsv880478 CNV Loss 21882294
dgv5860n71 CNV Gain 21882294
nsv880937 CNV Loss 21882294
nsv10629 CNV Loss 18304495
dgv5861n71 CNV Gain 21882294
nsv461870 CNV Gain 19166990
nsv470098 CNV Gain 18288195
nsv880982 CNV Gain 21882294
nsv461871 CNV Gain 19166990
nsv880626 CNV Gain 21882294
nsv881101 CNV Gain 21882294
nsv7367 OTHER Inversion 18451855
dgv332n21 CNV Loss 19592680
nsv880458 CNV Gain 21882294
nsv830173 CNV Gain 17160897
nsv519300 CNV Gain+Loss 19592680

Variation tolerance for ZFP42 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP42 Gene

HapMap Linkage Disequilibrium report
ZFP42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP42 Gene

Disorders for ZFP42 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFP42 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mixed germ cell cancer
  • mixed germ cell neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search ZFP42 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZFP42

Human Genome Epidemiology (HuGE) Navigator
ZFP42
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP42
genes like me logo Genes that share disorders with ZFP42: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFP42 Gene

Publications for ZFP42 Gene

  1. Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens. (PMID: 12110702) Henderson J.K. … Andrews P.W. (Stem Cells 2002) 2 3 4 67
  2. Transcriptional regulation of Rex1 (zfp42) in normal prostate epithelial cells and prostate cancer cells. (PMID: 20232320) Lee M.Y. … Gudas L.J. (J. Cell. Physiol. 2010) 3 23
  3. Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma. (PMID: 16344273) Raman J.D. … Gudas L.J. (Carcinogenesis 2006) 3 23
  4. The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures. (PMID: 16865673) Mongan N.P. … Gudas L.J. (Mol. Carcinog. 2006) 3 23
  5. Cobalt chloride supplementation induces stem-cell marker expression and inhibits osteoblastic differentiation in human periodontal ligament cells. (PMID: 25244616) Osathanon T. … Sooampon S. (Arch. Oral Biol. 2015) 3

Products for ZFP42 Gene

Sources for ZFP42 Gene

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