Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ZFP42 Gene

protein-coding   GIFtS: 56
GCID: GC04P188916

ZFP42 Zinc Finger Protein

(Previous names: zinc finger protein 42 homolog (mouse), zinc finger protein...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ZFP42 Zinc Finger Protein1 2     Zinc Finger Protein 421
REX12 3 5     Zinc Finger Protein 42 Homolog (Mouse)1
Reduced Expression Protein 12 3     REX1 Transcription Factor2
Zinc Finger Protein 7542 3     zfp-422
REX-12 3     Zinc Finger Protein 42 Homolog2
ZNF7542 3     Zfp-423
hREX-12 3     

External Ids:    HGNC: 309491   Entrez Gene: 1326252   Ensembl: ENSG000001790597   OMIM: 6145725   UniProtKB: Q96MM33   

Export aliases for ZFP42 gene to outside databases

Previous GC identifers: GC04P189596 GC04P189612 GC04P189292 GC04P189153 GC04P184653


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ZFP42 Gene:
ZFP42 (ZFP42 zinc finger protein) is a protein-coding gene. Diseases associated with ZFP42 include chromophobe adenocarcinoma, and male germ cell tumor. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF787.

UniProtKB/Swiss-Prot: ZFP42_HUMAN, Q96MM3
Function: Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency.
Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the
TSIX promoter. Involved in ES cell self-renewal (By similarity)

Gene Wiki entry for ZFP42 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFP42 gene promoter:
         SRF   Gfi-1   MEF-2A   Max   Nkx6-1   POU2F1   POU2F1a   aMEF-2   Ik-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZFP42 promoter sequence
   Search Chromatin IP Primers for ZFP42

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFP42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.2   Ensembl cytogenetic band:  4q35.2   HGNC cytogenetic band: 4q35.2

ZFP42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP42 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P188916:  view genomic region     (about GC identifiers)

Start:
188,916,925 bp from pter      End:
188,926,204 bp from pter
Size:
9,280 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ZFP42_HUMAN, Q96MM3 (See protein sequence)
Recommended Name: Zinc finger protein 42 homolog  
Size: 310 amino acids; 34802 Da
Secondary accessions: D3DP65 Q8WXE2

Explore the universe of human proteins at neXtProt for ZFP42: NX_Q96MM3

Explore proteomics data for ZFP42 at MOPED

Post-translational modifications: 

  • Polyubiquitinated by RNF12, leading to proteasomal degradation (By similarity)1
  • Ubiquitination2 at Lys231, Lys233
  • Modification sites at PhosphoSitePlus

  • See ZFP42 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_777560.2  
    ENSEMBL proteins: 
     ENSP00000424662   ENSP00000317686  

    ZFP42 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ZFP42
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ZFP42
    GenScript Custom Purified and Recombinant Proteins Services for ZFP42
    Novus Biologicals ZFP42 Protein
    Novus Biologicals ZFP42 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZFP42

    ZFP42 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ZFP42
    R&D Systems Antibodies for ZFP42 (Rex-1/ZFP42)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZFP42
    Novus Biologicals ZFP42 Antibodies
    Search for Antibodies for ZFP42 at Abcam
    Cloud-Clone Corp. Antibodies for ZFP42
    ThermoFisher Antibody for ZFP42
    LSBio Antibodies in human, mouse, rat for ZFP42

    ZFP42 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZFP42
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZFP42
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZFP42
    Cloud-Clone Corp. CLIAs for ZFP42


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96MM3

    ProtoNet protein and cluster: Q96MM3

    UniProtKB/Swiss-Prot: ZFP42_HUMAN, Q96MM3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers


    ZFP42 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFP42_HUMAN, Q96MM3
    Function: Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency.
    Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the
    TSIX promoter. Involved in ES cell self-renewal (By similarity)
    Induction: Down-regulated upon retinoic acid addition to F9 stem cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS14688391
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZFP42 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZFP42:
     Increased 8N DNA content 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Zfp42):
     cellular  endocrine/exocrine gland  mortality/aging  reproductive system 

    ZFP42 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zfp42tm1.1Log for ZFP42

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZFP42
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZFP42

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZFP42
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZFP42

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ZFP42 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate ZFP42:
    hsa-miR-3671 hsa-miR-569 hsa-miR-3140-3p hsa-miR-16-2* hsa-miR-195* hsa-miR-802
    SwitchGear 3'UTR luciferase reporter plasmidZFP42 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZFP42
    Predesigned siRNA for gene silencing in human, mouse, rat ZFP42

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZFP42

    Clone
    Products:
         
    OriGene clones in human, mouse for ZFP42 (see all 5)
    OriGene ORF clones in mouse, rat for ZFP42
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZFP42 (NM_174900)
    Sino Biological Human cDNA Clone for ZFP42
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFP42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP42

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZFP42
    Browse ESI BIO Cell Lines and PureStem Progenitors for ZFP42 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP42


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ZFP42_HUMAN, Q96MM3: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA16344273
    GO:0043234protein complex IEA--

    ZFP42 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ZFP42 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cardiac Progenitor Differentiation
    Cardiac Progenitor Differentiation


    1 BioSystems Pathway for ZFP42
        Cardiac Progenitor Differentiation



        Pathway & Disease-focused RT2 Profiler PCR Arrays including ZFP42: 
              Cell Lineage Identification in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ZFP42

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZFP42 (Q96MM33 ENSP000003176864) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603, ENSP000003730164I2D: score=2 STRING: ENSP00000373016
    ENSG00000229094Q018603, ENSP000003888424I2D: score=2 STRING: ENSP00000388842
    ENSG00000230336Q018603, ENSP000004000474I2D: score=2 STRING: ENSP00000400047
    ENSG00000233911Q018603, ENSP000003928774I2D: score=2 STRING: ENSP00000392877
    ENSG00000235068Q018603, ENSP000004050414I2D: score=2 STRING: ENSP00000405041
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0007126meiotic nuclear division NAS18281244
    GO:0007286spermatid development IEA--
    GO:0008584male gonad development IEP18281244

    ZFP42 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFP42

    1 Novoseek inferred chemical compound relationship for ZFP42 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 12.6 7 16865673 (3), 16344273 (1)



    ZFP42 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ZFP42 gene: 
    NM_174900.3  

    Unigene Cluster for ZFP42:

    ZFP42 zinc finger protein
    Hs.335787  [show with all ESTs]
    Unigene Representative Sequence: AY429593
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509524(uc003izi.1) ENST00000326866(uc003izh.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZFP42 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate ZFP42:
    hsa-miR-3671 hsa-miR-569 hsa-miR-3140-3p hsa-miR-16-2* hsa-miR-195* hsa-miR-802
    SwitchGear 3'UTR luciferase reporter plasmidZFP42 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZFP42
    Predesigned siRNA for gene silencing in human, mouse, rat ZFP42
    Clone
    Products:
         
    OriGene clones in human, mouse for ZFP42 (see all 5)
    OriGene ORF clones in mouse, rat for ZFP42
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZFP42 (NM_174900)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFP42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP42
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZFP42
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZFP42
      QuantiTect SYBR Green Assays in human, mouse, rat ZFP42
      QuantiFast Probe-based Assays in human, mouse, rat ZFP42

    Additional mRNA sequence: 

    AF450454.1 AK056719.1 AY429593.1 

    3 DOTS entries:

    DT.99993904  DT.95260486  DT.40123233 

    20 AceView cDNA sequences:

    BX336340 AA906796 AW673744 AF450454 CR624529 AW665472 AY429593 BX103592 
    AK056719 AA738254 BX369178 BX369177 BE301754 NM_174900 N32798 BX336339 
    BI092935 N42241 AW673107 AA641545 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZFP42    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
    SP1:                                                
    SP2:                    -                           
    SP3:                    -                           


    ECgene alternative splicing isoforms for ZFP42

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ZFP42 expression in normal human tissues (normalized intensities)      ZFP42 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATAGCCCT
    ZFP42 Expression
    About this image


    ZFP42 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 25 entries
             Inner Cell Mass Cells Inner Cell Mass
             VUB03_DM1
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 5 entries
             Early Epiblast Cells Epiblast
             Epiblast Stem Cells
             Epiblast-like cells
     
     NULL (Uncategorized)    fully expand to see all 3 entries
             Vascular endothelial growth factor-induced cells
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Heart (Cardiovascular System)
             Human cardiac stem cells
    ZFP42 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFP42 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.335787

    UniProtKB/Swiss-Prot: ZFP42_HUMAN, Q96MM3
    Tissue specificity: Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small
    airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines
    (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial
    cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant
    kidney and several carcinoma cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ZFP42: 
              Cell Lineage Identification in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZFP42
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZFP42
    QuantiTect SYBR Green Assays in human, mouse, rat ZFP42
    QuantiFast Probe-based Assays in human, mouse, rat ZFP42
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP42

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ZFP42 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp421 , 5 zinc finger protein 421, 5 66.31(n)1
    58.21(a)1
      8 (23.89 cM)5
    227021  NM_009556.31  NP_033582.21 
     432950685 
    chicken
    (Gallus gallus)
    Aves YY16
    Gallus gallus YY1 transcription factor (YY1), mRNA...
    69(a)
    1 → many
    5(48418077-48431424)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    69(a)
    1 → many
    GL343270.1(988957-993664)
    zebrafish
    (Danio rerio)
    Actinopterygii yy1a6
    yy1b6
    YY1 transcription factor b
    41(a)
    39(a)
    many ↔ many
    many ↔ many
    17(30916118-30922362) ENSDARG00000042796
    20(54760868-54773885) ENSDARG00000027978
    fruit fly
    (Drosophila melanogaster)
    Insecta pho6
    phol6
    pleiohomeotic like
    20(a)
    16(a)
    many ↔ many
    many ↔ many
    4(1193094-1202271)
    3L(9446148-9449381)


    ENSEMBL Gene Tree for ZFP42 (if available)
    TreeFam Gene Tree for ZFP42 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ZFP42 gene
    ZNF7872  YY22  ZNF8532  YY12  
    2 SIMAP similar genes for ZFP42 using alignment to 1 protein entry:     ZFP42_HUMAN:
    YY2    YY1

    ZFP42 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ZFP42 (see all 308)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs760959941,2
    C,F--188914982(+) CTTGAG/ACTAAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs761149941,2
    C,F--188914988(+) CTAAGT/CGTGTG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs752092251,2
    C,F--188915114(+) TGTTAA/TCATTT 1 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1419872761,2
    --188915215(+) GGGAAG/TTTGAG 1 -- us2k10--------
    rs1163489041,2
    C,F--188915260(+) CCCTCG/TTCTGC 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1462667491,2
    C--188915408(+) CAGGCG/TCAGTG 1 -- us2k10--------
    rs1925960761,2
    C--188915552(+) TGTAAG/TCCCAG 1 -- us2k10--------
    rs2010413881,2
    C--188915700(+) AAAGA-/AAG   
       GAAGG
    AAGGA
    1 -- us2k10--------
    rs1848142721,2
    --188915731(+) GGAAGA/GAAGGA 1 -- us2k10--------
    rs1499195741,2
    --188915933(+) TATACC/GACCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZFP42 (188916925 - 188926204 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZFP42 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv880937CNV Loss21882294
    dgv332n21CNV Loss19592680
    nsv880478CNV Loss21882294
    nsv10629CNV Loss18304495
    nsv880458CNV Gain21882294
    nsv461871CNV Gain19166990
    nsv880982CNV Gain21882294
    nsv461870CNV Gain19166990
    dgv5861n71CNV Gain21882294
    esv2752041CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFP42
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFP42

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614572    OMIM disorders: --

    10 diseases for ZFP42:    About MalaCards
    chromophobe adenocarcinoma    male germ cell tumor    seminoma    germ cell tumors
    teratocarcinoma    renal cell carcinoma    periodontitis    adenocarcinoma
    prostatitis    prostate cancer

    3 diseases from the University of Copenhagen DISEASES database for ZFP42:
    Teratocarcinoma     Chromophobe adenocarcinoma     Embryonal carcinoma

    ZFP42 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ZFP42 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 8 16344273 (6)
    carcinoma 0 3 16865673 (1), 16344273 (1)

    Human Genome Epidemiology (HuGE) Navigator: ZFP42 (1 document)

    Export disorders for ZFP42 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ZFP42 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with ZFP42)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens. (PubMed id 12110702)1, 2, 3 Henderson J.K.... Andrews P.W. (Stem Cells 2002)
    2. Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma. (PubMed id 16344273)1, 2, 9 Raman J.D....Gudas L.J. (Carcinogenesis 2006)
    3. The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures. (PubMed id 16865673)1, 2, 9 Mongan N.P.... Gudas L.J. (Mol. Carcinog. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Transcriptional regulation of Rex1 (zfp42) in normal prostate epithelial cells and prostate cancer cells. (PubMed id 20232320)1, 9 Lee M.Y....Gudas L.J. (J. Cell. Physiol. 2010)
    6. Association of Rex-1 to target genes supports its interaction with Polycomb function. (PubMed id 21530438)1 Garcia-TuA+on I....Schoorlemmer J. (Stem Cell Res 2011)
    7. Embryonic stem cell factors undifferentiated transcription factor-1 (UFT-1) and reduced expression protein-1 (REX-1) are widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination. (PubMed id 21446939)1 Reinisch C.M....Pammer J. (Int J Exp Pathol 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. (PubMed id 18281244)1 Kristensen D.M....Leffers H. (Hum. Reprod. 2008)
    10. Oct-4, Rex-1, and Gata-4 expression in human MSC increase the differentiation efficiency but not hTERT expression. (PubMed id 17211834)1 Roche S....Favrot M.C. (J. Cell. Biochem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 132625 HGNC: 30949 AceView: ZFP42 Ensembl:ENSG00000179059 euGenes: HUgn132625
    ECgene: ZFP42 H-InvDB: ZFP42

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ZFP42 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ZFP42 gene:
    Search GeneIP for patents involving ZFP42

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of ZFP42
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for ZFP42 (Rex-1/ZFP42)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZFP42  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ZFP42  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZFP42  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZFP42   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZFP42   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZFP42   OriGene Custom Protein Services for ZFP42  

     
     
     Block miRNA regulation of human, mouse, rat ZFP42 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZFP42
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFP42 Predesigned siRNA for gene silencing in human, mouse, rat ZFP42
     QuantiFast Probe-based Assays in human, mouse, rat ZFP42 QuantiTect SYBR Green Assays in human, mouse, rat ZFP42
     PCR Arrays including human, mouse, rat ZFP42 Search Chromatin IP Primers for ZFP42
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZFP42  GeneGlobe Interaction Network for ZFP42
     Regulatory tfbs in ZFP42 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ZFP42 GenScript cDNA clones with any tag delivered in your preferred vector for ZFP42
     GenScript Custom Assay Services for ZFP42 GenScript Custom overexpressing Cell Line Services for ZFP42
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ZFP42
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ZFP42
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ZFP42 antibodies
     ZFP42 proteins
     ZFP42 lysates
     Search for Antibodies for ZFP42 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ZFP42
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ZFP42
     Antibodies for ZFP42
     ELISAs for ZFP42
     CLIAs for ZFP42



     Browse ESI BIO Cell Lines and PureStem Progenitors for ZFP42
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP42
     SwitchGear 3'UTR luciferase reporter plasmids for ZFP42
     SwitchGear Promoter luciferase reporter plasmids for ZFP42
     ThermoFisher Antibody for ZFP42
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP42
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZFP42
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZFP42
     LSBio Antibodies in human, mouse, rat for ZFP42
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZFP42 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4