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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFP42 Gene

protein-coding   GIFtS: 57
GCID: GC04P188916

ZFP42 Zinc Finger Protein

(Previous names: zinc finger protein 42 homolog (mouse), zinc finger protein...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ZFP42 Zinc Finger Protein1 2     Zinc Finger Protein 421
Reduced Expression Protein 12 3     Zinc Finger Protein 42 Homolog (Mouse)1
Zinc Finger Protein 7542 3     REX1 Transcription Factor2
REX-12 3     zfp-422
REX12 3     Zinc Finger Protein 42 Homolog2
ZNF7542 3     Zfp-423
hREX-12 3     

External Ids:    HGNC: 309491   Entrez Gene: 1326252   Ensembl: ENSG000001790597   OMIM: 6145725   UniProtKB: Q96MM33   

Export aliases for ZFP42 gene to outside databases

Previous GC identifers: GC04P189596 GC04P189612 GC04P189292 GC04P189153 GC04P184653


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZFP42 Gene: 
ZFP42 (ZFP42 zinc finger protein) is a protein-coding gene. Diseases associated with ZFP42 include chromophobe adenocarcinoma, and germ cell tumors. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF787.

UniProtKB/Swiss-Prot: ZFP42_HUMAN, Q96MM3
Function: Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency.
Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the
TSIX promoter. Involved in ES cell self-renewal (By similarity)

Gene Wiki entry for ZFP42 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFP42 gene promoter:
         SRF   Gfi-1   MEF-2A   Max   Nkx6-1   POU2F1   POU2F1a   aMEF-2   Ik-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZFP42 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFP42

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.2   Ensembl cytogenetic band:  4q35.2   HGNC cytogenetic band: 4q35.2

ZFP42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP42 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P188916:  view genomic region     (about GC identifiers)

Start:
188,916,925 bp from pter      End:
188,926,204 bp from pter
Size:
9,280 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZFP42_HUMAN, Q96MM3 (See protein sequence)
Recommended Name: Zinc finger protein 42 homolog  
Size: 310 amino acids; 34802 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: D3DP65 Q8WXE2

Explore the universe of human proteins at neXtProt for ZFP42: NX_Q96MM3

Explore proteomics data for ZFP42 at MOPED 

Post-translational modifications:

  • UniProtKB: Polyubiquitinated by RNF12, leading to proteasomal degradation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96MM3

  • ZFP42 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFP42 Protein Expression
    REFSEQ proteins: NP_777560.2  
    ENSEMBL proteins: 
     ENSP00000424662   ENSP00000317686  

    Human Recombinant Protein Products for ZFP42: 
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    OriGene Protein Over-expression Lysate for ZFP42
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    OriGene Custom Protein Services for ZFP42
    GenScript Custom Purified and Recombinant Proteins Services for ZFP42
    Novus Biologicals ZFP42 Protein
    Novus Biologicals ZFP42 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZFP42 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA16344273

    ZFP42 for ontologies           About GeneDecksing



    ZFP42 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for ZFP42 

    Assay Products for ZFP42: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ZFP42 
    Cloud-Clone Corp. CLIAs for ZFP42


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96MM3

    ProtoNet protein and cluster: Q96MM3

    UniProtKB/Swiss-Prot: ZFP42_HUMAN, Q96MM3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers


    ZFP42 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFP42_HUMAN, Q96MM3
    Function: Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency.
    Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the
    TSIX promoter. Involved in ES cell self-renewal (By similarity)
    Induction: Down-regulated upon retinoic acid addition to F9 stem cells

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS14688391
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZFP42 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZFP42:
     Increased 8N DNA content 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Zfp42):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  reproductive system 

    ZFP42 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zfp42tm1.1Log for ZFP42

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFP42 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZFP42

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZFP42 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZFP42 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFP42
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFP42:
    hsa-miR-3671 hsa-miR-569 hsa-miR-3140-3p hsa-miR-16-2* hsa-miR-195* hsa-miR-802
    SwitchGear 3'UTR luciferase reporter plasmidZFP42 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZFP42
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    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for ZFP42
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    GenScript: all cDNA clones in your preferred vector: ZFP42 (NM_174900)
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    Sirion Biotech Customized lentivirus for stable overexpression of ZFP42 
                         Customized lentivirus expression plasmids for stable overexpression of ZFP42 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP42


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZFP42 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cardiac Progenitor Differentiation
    Cardiac Progenitor Differentiation


    1 BioSystems Pathway for ZFP42
        Cardiac Progenitor Differentiation



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFP42

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/25 Interacting proteins for ZFP42 (Q96MM33 ENSP000003176864) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603I2D: score=2 
    ENSG00000229094Q018603I2D: score=2 
    ENSG00000230336Q018603I2D: score=2 
    ENSG00000233911Q018603I2D: score=2 
    ENSG00000235068Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development ----
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007126meiosis NAS18281244
    GO:0007286spermatid development ----
    GO:0008584male gonad development IEP18281244

    ZFP42 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZFP42 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFP42

    1 Novoseek inferred chemical compound relationship for ZFP42 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 12.6 7 16865673 (3), 16344273 (1)

    Search CenterWatch for drugs/clinical trials and news about ZFP42

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFP42 gene: 
    NM_174900.3  

    Unigene Cluster for ZFP42:

    ZFP42 zinc finger protein
    Hs.335787  [show with all ESTs]
    Unigene Representative Sequence: AY429593
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509524(uc003izi.1) ENST00000326866(uc003izh.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFP42
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFP42:
    hsa-miR-3671 hsa-miR-569 hsa-miR-3140-3p hsa-miR-16-2* hsa-miR-195* hsa-miR-802
    SwitchGear 3'UTR luciferase reporter plasmidZFP42 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZFP42
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFP42
    Clone
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    OriGene clones in human, mouse for ZFP42 (see all 6)
    OriGene ORF clones in mouse, rat for ZFP42
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZFP42 (NM_174900)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFP42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP42
    Sirion Biotech Customized lentivirus for stable overexpression of ZFP42 
                         Customized lentivirus expression plasmids for stable overexpression of ZFP42 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZFP42
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFP42
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFP42
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP42

    Additional mRNA sequence: 

    AF450454.1 AK056719.1 AY429593.1 

    3 DOTS entries:

    DT.99993904  DT.95260486  DT.40123233 

    20 AceView cDNA sequences:

    CR624529 AA906796 AF450454 AW673744 BX336340 AW665472 BX103592 BX369178 
    AY429593 BX369177 AK056719 AA738254 NM_174900 N32798 BE301754 BI092935 
    BX336339 N42241 AA641545 AW673107 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZFP42    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
    SP1:                                                
    SP2:                    -                           
    SP3:                    -                           


    ECgene alternative splicing isoforms for ZFP42

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFP42 expression in normal human tissues (normalized intensities)      ZFP42 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATAGCCCT
    ZFP42 Expression
    About this image


    ZFP42 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 25 entries
             Inner Cell Mass Cells Inner Cell Mass
             VUB03_DM1
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 4 entries
             Early Epiblast Cells Epiblast
             Epiblast Stem Cells
     
     Primitive Streak (Early Embryonic Tissues)
             Mesendoderm-like cells ( Generation of mesendoderm and definitive endoderm cells...
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Uncategorized (Extraembryonic Tissues)
             Extra-embryonic endoderm cells

    See ZFP42 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFP42

    SOURCE GeneReport for Unigene cluster: Hs.335787

    UniProtKB/Swiss-Prot: ZFP42_HUMAN, Q96MM3
    Tissue specificity: Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small
    airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines
    (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial
    cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant
    kidney and several carcinoma cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including ZFP42: 
              Cell Lineage Identification in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Embryonic Stem Cells in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP42

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZFP42 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp421 , 5 zinc finger protein 421, 5 66.31(n)1
    58.21(a)1
      8 (23.89 cM)5
    227021  NM_009556.31  NP_033582.21 
     432950685 


    ENSEMBL Gene Tree for ZFP42 (if available)
    TreeFam Gene Tree for ZFP42 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFP42 gene
    ZNF7872  YY22  ZNF8532  YY12  
    2 SIMAP similar genes for ZFP42 using alignment to 1 protein entry:     ZFP42_HUMAN:
    YY2    YY1

    ZFP42 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/308 SNPs in ZFP42 are shown (see all 308)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs760959941,2
    C,F--188914982(+) CTTGAG/ACTAAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs761149941,2
    C,F--188914988(+) CTAAGT/CGTGTG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs752092251,2
    C,F--188915114(+) TGTTAA/TCATTT 1 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1419872761,2
    --188915215(+) GGGAAG/TTTGAG 1 -- us2k10--------
    rs1163489041,2
    C,F--188915260(+) CCCTCG/TTCTGC 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1462667491,2
    C--188915408(+) CAGGCG/TCAGTG 1 -- us2k10--------
    rs1925960761,2
    C--188915552(+) TGTAAG/TCCCAG 1 -- us2k10--------
    rs2010413881,2
    C--188915700(+) AAAGA-/AAG   
       GAAGG
    AAGGA
    1 -- us2k10--------
    rs1848142721,2
    --188915731(+) GGAAGA/GAAGGA 1 -- us2k10--------
    rs1499195741,2
    --188915933(+) TATACC/GACCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZFP42 (188916925 - 188926204 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for ZFP42 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv880937CNV Loss21882294
    dgv332n21CNV Loss19592680
    nsv880478CNV Loss21882294
    nsv10629CNV Loss18304495
    nsv880458CNV Gain21882294
    nsv461871CNV Gain19166990
    nsv880982CNV Gain21882294
    nsv461870CNV Gain19166990
    dgv5861n71CNV Gain21882294
    esv2752041CNV Gain17911159

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFP42
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFP42

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614572    OMIM disorders: --

    8 diseases for ZFP42:    About MalaCards
    chromophobe adenocarcinoma    germ cell tumors    seminoma    teratocarcinoma
    renal cell carcinoma    prostate cancer    prostatitis    adenocarcinoma

    3 diseases from the University of Copenhagen DISEASES database for ZFP42:
    Teratocarcinoma     Chromophobe adenocarcinoma     Embryonal carcinoma

    ZFP42 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ZFP42 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 8 16344273 (6)
    carcinoma 0 3 16865673 (1), 16344273 (1)

    Human Genome Epidemiology (HuGE) Navigator: ZFP42 (1 document)

    Export disorders for ZFP42 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFP42 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with ZFP42)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens. (PubMed id 12110702)1, 2, 3 Henderson J.K.... Andrews P.W. (2002)
    2. Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma. (PubMed id 16344273)1, 2, 9 Raman J.D....Gudas L.J. (2006)
    3. The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures. (PubMed id 16865673)1, 2, 9 Mongan N.P.... Gudas L.J. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Transcriptional regulation of Rex1 (zfp42) in normal prostate epithelial cells and prostate cancer cells. (PubMed id 20232320)1, 9 Lee M.Y....Gudas L.J. (2010)
    6. Association of Rex-1 to target genes supports its inte raction with Polycomb function. (PubMed id 21530438)1 Garcia-Tunon I....Schoorlemmer J. (2011)
    7. Embryonic stem cell factors undifferentiated transcri ption factor-1 (UFT-1) and reduced expression protein-1 (REX-1) are widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination. (PubMed id 21446939)1 Reinisch C.M....Pammer J. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. (PubMed id 18281244)1 Kristensen D.M....Leffers H. (2008)
    10. Oct-4, Rex-1, and Gata-4 expression in human MSC increase the differentiation efficiency but not hTERT expression. (PubMed id 17211834)1 Roche S....Favrot M.C. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 132625 HGNC: 30949 AceView: ZFP42 Ensembl:ENSG00000179059 euGenes: HUgn132625
    ECgene: ZFP42 H-InvDB: ZFP42

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFP42 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFP42 gene:
    Search GeneIP for patents involving ZFP42

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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