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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFP41 Gene

protein-coding   GIFtS: 39
GCID: GC08P144331

ZFP41 Zinc Finger Protein

(Previous name: zinc finger protein 41 homolog (mouse))
  Search for ZFP41
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ZFP41 Zinc Finger Protein1 2
Zinc Finger Protein 41 Homolog (Mouse)1
ZNF7532
zfp-412
Zinc Finger Protein 41 Homolog2
Zfp-413

External Ids:    HGNC: 267861   Entrez Gene: 2861282   Ensembl: ENSG000001816387   UniProtKB: Q8N8Y53   

Export aliases for ZFP41 gene to outside databases

Previous GC identifers: GC08P144404 GC08P144330 GC08P139582


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZFP41 Gene: 
ZFP41 (ZFP41 zinc finger protein) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF696.

UniProtKB/Swiss-Prot: ZFP41_HUMAN, Q8N8Y5
Function: A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFP41 gene promoter:
         Bach1   Olf-1   STAT5A   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFP41 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFP41

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP41


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

ZFP41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP41 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P144331:  view genomic region     (about GC identifiers)

Start:
144,328,991 bp from pter      End:
144,344,875 bp from pter
Size:
15,885 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZFP41_HUMAN, Q8N8Y5 (See protein sequence)
Recommended Name: Zinc finger protein 41 homolog  
Size: 198 amino acids; 22806 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: D3DWJ5

Explore the universe of human proteins at neXtProt for ZFP41: NX_Q8N8Y5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N8Y5

  • ZFP41 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (2 alternative transcripts): 
    NP_001258085.1  NP_776193.1  

    ENSEMBL proteins: 
     ENSP00000430465   ENSP00000327427  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZFP41 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N8Y5

    ProtoNet protein and cluster: Q8N8Y5

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZFP41_HUMAN, Q8N8Y5
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers


    ZFP41 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFP41_HUMAN, Q8N8Y5
    Function: A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZFP41 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFP41

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--

    ZFP41 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFP41

    Search CenterWatch for drugs/clinical trials and news about ZFP41

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFP41 gene (2 alternative transcripts): 
    NM_001271156.1  NM_173832.4  

    Unigene Cluster for ZFP41:

    ZFP41 zinc finger protein
    Hs.668016  [show with all ESTs]
    Unigene Representative Sequence: NM_173832
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520584 ENST00000330701(uc003yxw.3) ENST00000522233 ENST00000517702

    miRNA
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    hsa-miR-548q
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK021976.1 AK024438.1 AK096024.1 BC034608.1 

    5 DOTS entries:

    DT.97777412  DT.209472  DT.65284636  DT.75138585  DT.86836948 

    2 AceView cDNA sequences:

    AK024438 AW504235 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ZFP41 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14
    SP1:                                                                                                                                    
    SP2:                                                                                -     -                                             
    SP3:                                                                                -     -                 -     -     -     -         
    SP4:                                                                                -     -     -                                       
    SP5:                                                                                -     -                 -     -                     


    ECgene alternative splicing isoforms for ZFP41

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFP41 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTGTGGCG
    ZFP41 Expression
    About this image


    Genevestigator expression for ZFP41

    SOURCE GeneReport for Unigene cluster: Hs.668016
        SABiosciences Custom PCR Arrays for ZFP41
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZFP41 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp411 , 5 zinc finger protein 411, 5 78.17(n)1
    81.22(a)1
      15 (34.62 cM)5
    227011  NM_011759.21  NP_035889.11 
     756166795 


    ENSEMBL Gene Tree for ZFP41 (if available)
    TreeFam Gene Tree for ZFP41 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFP41 gene
    ZNF6962  GLI42  ENSG000002646682  
    18/491 SIMAP similar genes for ZFP41 using alignment to 1 protein entry:     ZFP41_HUMAN(see all similar genes):
    DKFZp761O1618    ZNF418    ZNF78L1    DKFZp547L155    ZNF132    ZNF16
    ZNF397    ZFP37    ZNF135    ZNF211    ZNF79    DKFZp686O111
    ZFP2    ZIK1    ZNF22    ZNF286A    ZNF286B    ZNF391

    ZFP41 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZFP41
    PGOHUM00000248141


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/498 SNPs in ZFP41 are shown (see all 498)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1141379751,2
    F--144327025(+) AGGGGC/TGGCCT 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1845826161,2
    --144327087(+) CTGCAA/GGACAG 1 -- us2k10--------
    rs1395232111,2
    --144327127(+) TGCCCA/GGTAAG 2 -- us2k10--------
    rs573622151,2
    C--144327187(+) GCAGG-/GAGACC 2 -- us2k12Minor allele frequency- G:0.25NA 4
    rs786163291,2
    C,F--144327194(+) GAGACC/GCCAGG 2 -- us2k12Minor allele frequency- G:0.05WA 120
    rs780657421,2
    C,F--144327209(+) GGCACA/GGAAGT 2 -- us2k11Minor allele frequency- G:0.09WA 118
    rs1442435841,2
    C--144327252(+) GGACAC/GAGGAA 2 -- us2k10--------
    rs1146622061,2
    F--144327268(+) CTGGAC/GAAGAG 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs73878811,2
    C,F,A,H--144327296(+) TGGGAG/AGTAAA 2 -- us2k18Minor allele frequency- A:0.42NA WA EA 368
    rs733762781,2
    C,F--144327349(+) AACTGC/TCTGGT 2 -- us2k13Minor allele frequency- T:0.10WA CSA 122

    HapMap Linkage Disequilibrium report for ZFP41 (144328991 - 144344875 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for ZFP41 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2737981CNV Deletion23290073
    dgv7921n71CNV Loss21882294
    dgv7920n71CNV Loss21882294
    dgv7922n71CNV Loss21882294
    nsv891671CNV Loss21882294
    nsv465992CNV Loss19166990
    nsv891660CNV Loss21882294
    nsv891669CNV Loss21882294
    dgv7923n71CNV Loss21882294
    nsv891656CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFP41 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZFP41)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 3 Hattori A.... Ohara O. (2000)
    3. A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Expression of a mouse zinc finger protein gene in both spermatocytes and oocytes during meiosis. (PubMed id 1397691)1 Noce T....Higashinakagawa T. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 286128 HGNC: 26786 AceView: FLJ38705 Ensembl:ENSG00000181638 euGenes: HUgn286128
    ECgene: ZFP41 H-InvDB: ZFP41

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFP41 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFP41 gene:
    Search GeneIP for patents involving ZFP41

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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