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Aliases for ZFP37 Gene

Aliases for ZFP37 Gene

  • ZFP37 Zinc Finger Protein 2 3
  • Zinc Finger Protein Homologous To Zfp37 In Mouse 2 3
  • Zfp-37 3 4
  • Zinc Finger Protein 37 Homolog (Mouse) 2
  • Zinc Finger Protein 37 Homolog 3
  • ZNF906 3

External Ids for ZFP37 Gene

Summaries for ZFP37 Gene

Entrez Gene Summary for ZFP37 Gene

  • This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for ZFP37 Gene

ZFP37 (ZFP37 Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF10.

UniProtKB/Swiss-Prot for ZFP37 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP37 Gene

Genomics for ZFP37 Gene

Genomic Location for ZFP37 Gene

Start:
113,038,380 bp from pter
End:
113,056,791 bp from pter
Size:
18,412 bases
Orientation:
Minus strand

Genomic View for ZFP37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFP37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP37 Gene

Regulatory Elements for ZFP37 Gene

Proteins for ZFP37 Gene

  • Protein details for ZFP37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6Q3-ZFP37_HUMAN
    Recommended name:
    Zinc finger protein 37 homolog
    Protein Accession:
    Q9Y6Q3
    Secondary Accessions:
    • A0AVJ9
    • B4DVX4
    • G3V3L7
    • Q5T7Q4

    Protein attributes for ZFP37 Gene

    Size:
    630 amino acids
    Molecular mass:
    71209 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZFP37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP37 Gene

Proteomics data for ZFP37 Gene at MOPED

Post-translational modifications for ZFP37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP37 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFP37 Gene

Domains for ZFP37 Gene

Gene Families for ZFP37 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZFP37 Gene

UniProtKB/Swiss-Prot:

ZFP37_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q9Y6Q3
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9Y6Q3
Similarity:
  • Contains 12 C2H2-type zinc fingers.:
    • Q9Y6Q3
genes like me logo Genes that share domains with ZFP37: view

Function for ZFP37 Gene

Molecular function for ZFP37 Gene

GENATLAS Biochemistry: zinc finger protein 37,with a Kruppel-associated box domain (KRAB domain),expressed in fetal cartilage
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZFP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 9585434
GO:0008270 zinc ion binding NAS 9585434
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with ZFP37: view

Phenotypes for ZFP37 Gene

GenomeRNAi human phenotypes for ZFP37:
genes like me logo Genes that share phenotypes with ZFP37: view

miRNA for ZFP37 Gene

miRTarBase miRNAs that target ZFP37

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFP37 Gene

Localization for ZFP37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP37 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP37 Gene COMPARTMENTS Subcellular localization image for ZFP37 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZFP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP37: view

Pathways for ZFP37 Gene

SuperPathways for ZFP37 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP37: view

Pathways by source for ZFP37 Gene

2 Reactome pathways for ZFP37 Gene

Interacting Proteins for ZFP37 Gene

Gene Ontology (GO) - Biological Process for ZFP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 9585434
genes like me logo Genes that share ontologies with ZFP37: view

Transcripts for ZFP37 Gene

mRNA/cDNA for ZFP37 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP37 Gene

ZFP37 zinc finger protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP37 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for ZFP37 Gene

GeneLoc Exon Structure for
ZFP37
ECgene alternative splicing isoforms for
ZFP37

Expression for ZFP37 Gene

mRNA expression in normal human tissues for ZFP37 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFP37 Gene

SOURCE GeneReport for Unigene cluster for ZFP37 Gene Hs.150406

mRNA Expression by UniProt/SwissProt for ZFP37 Gene

Q9Y6Q3-ZFP37_HUMAN
Tissue specificity: Expressed at low level in several tissues including fetal cartilage
genes like me logo Genes that share expressions with ZFP37: view

Orthologs for ZFP37 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFP37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP37 36
  • 99.11 (n)
  • 97.87 (a)
ZFP37 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 53 (a)
ManyToMany
ZFP37 36
  • 87.59 (n)
  • 82.2 (a)
dog
(Canis familiaris)
Mammalia ZFP37 36
  • 88.04 (n)
  • 83.41 (a)
ZFP37 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp37 36
  • 80.73 (n)
  • 75.3 (a)
Zfp37 16
Zfp37 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp37 36
  • 77.78 (n)
  • 71.98 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7963 38
  • 36 (a)
CG3407 38
  • 38 (a)
CG9650 38
  • 45 (a)
dwg 38
  • 44 (a)
CG12299 38
  • 42 (a)
Neu2 38
  • 32 (a)
Kr-h1 38
  • 50 (a)
Species with no ortholog for ZFP37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP37 Gene

ENSEMBL:
Gene Tree for ZFP37 (if available)
TreeFam:
Gene Tree for ZFP37 (if available)

Paralogs for ZFP37 Gene

Selected SIMAP similar genes for ZFP37 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZFP37 Gene

genes like me logo Genes that share paralogs with ZFP37: view

Variants for ZFP37 Gene

Sequence variations from dbSNP and Humsavar for ZFP37 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1330691 -- 113,048,337(-) CAAAT(C/G)TCTTG intron-variant
rs1411605 -- 113,046,020(-) CTTTT(C/T)GGTTT intron-variant
rs1411606 -- 113,044,913(-) AAGAC(A/G/T)CAGTT intron-variant
rs2274761 -- 113,049,555(-) TGCTG(C/G)GGCTT intron-variant
rs2282076 - 113,056,669(-) CGGCG(A/T)CCAGA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ZFP37 Gene

Variant ID Type Subtype PubMed ID
dgv2412e1 CNV Complex 17122850
nsv466491 CNV Loss 19166990
nsv831691 CNV Loss 17160897
nsv517282 CNV Loss 19592680
nsv510987 CNV Complex 20534489
nsv508563 CNV Loss 20534489
nsv509318 CNV Insertion 20534489
nsv6672 CNV Loss 18451855
dgv1232n67 CNV Gain 20364138
nsv525545 CNV Gain 19592680
dgv943n27 CNV Loss 19166990
nsv893734 CNV Gain+Loss 21882294
dgv2415e1 CNV Complex 17122850
nsv8562 CNV Gain+Loss 18304495

Relevant External Links for ZFP37 Gene

HapMap Linkage Disequilibrium report
ZFP37

Disorders for ZFP37 Gene

No disorders were found for ZFP37 Gene.

No data available for UniProtKB/Swiss-Prot for ZFP37 Gene

Publications for ZFP37 Gene

  1. Cloning, characterization, and chromosomal assignment of the human ortholog of murine Zfp-37, a candidate gene for Nager syndrome. (PMID: 9585434) Dreyer S.D. … Lee B. (Mamm. Genome 1998) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4

Products for ZFP37 Gene

Sources for ZFP37 Gene

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