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Aliases for ZFP37 Gene

Aliases for ZFP37 Gene

  • ZFP37 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein Homologous To Zfp37 In Mouse 2 3
  • Zfp-37 3 4
  • Zinc Finger Protein 37 Homolog (Mouse) 2
  • Zinc Finger Protein 37 Homolog 3
  • ZNF906 3

External Ids for ZFP37 Gene

Previous GeneCards Identifiers for ZFP37 Gene

  • GC09M106602
  • GC09M107536
  • GC09M109217
  • GC09M111140
  • GC09M111141
  • GC09M112883
  • GC09M114840
  • GC09M115800
  • GC09M085402

Summaries for ZFP37 Gene

Entrez Gene Summary for ZFP37 Gene

  • This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for ZFP37 Gene

ZFP37 (ZFP37 Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF33A.

UniProtKB/Swiss-Prot for ZFP37 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP37 Gene

Genomics for ZFP37 Gene

Regulatory Elements for ZFP37 Gene

Enhancers for ZFP37 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F112860 1.4 FANTOM5 Ensembl ENCODE 16.5 +194.2 194190 4.4 ZFP64 ZNF140 ZMYM3 MAX ZNF101 ZNF433 ZBTB11 CEBPB REST ZBTB8A SLC46A2 SNX30 ZFP37 ENSG00000226609 SLC31A2 PRPF4 RNF183 ENSG00000271631 FKBP15 PIR49803
GH09F113510 1.4 FANTOM5 Ensembl ENCODE 14.8 -455.6 -455628 3.1 HDAC1 PKNOX1 TBL1XR1 BMI1 ZBTB40 RAD21 EGR1 ELK1 FOS CREM C9orf43 PRPF4 RGS3 ALAD ZFP37 RNF183 CDC26 GC09P113741
GH09F112753 1 Ensembl ENCODE 10.8 +300.9 300892 5.4 KLF1 ZKSCAN1 ZFHX2 GATA3 CTBP1 POLR2A ZNF239 PRDM10 FOS MAFK INIP ZFP37 SLC46A2 SNX30 ENSG00000226609 ENSG00000271631 PIR49803
GH09F113483 1 Ensembl ENCODE 10.8 -428.0 -428029 2.4 SOX13 JUN ZNF384 CEBPG ZNF316 ZNF239 FOS ZNF362 NFIA MAFG C9orf43 RGS3 ZFP37 ALAD POLE3 RNF183 SLC31A2 GC09P113741
GH09F113205 0.6 Ensembl 14.9 -149.3 -149310 1.0 ZNF316 MAFF ZNF585B MAFG EMSY MAFK ZFP37 PRPF4 POLE3 BSPRY SLC31A1 FKBP15 PIR31842
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFP37 on UCSC Golden Path with GeneCards custom track

Promoters for ZFP37 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001311942 190 1999 ATF1 ARID4B SIN3A ZNF48 ZNF2 ETS1 YY1 ELK1 CBX5 ZNF143

Genomic Location for ZFP37 Gene

Chromosome:
9
Start:
113,038,380 bp from pter
End:
113,056,791 bp from pter
Size:
18,412 bases
Orientation:
Minus strand

Genomic View for ZFP37 Gene

Genes around ZFP37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP37 Gene

Proteins for ZFP37 Gene

  • Protein details for ZFP37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6Q3-ZFP37_HUMAN
    Recommended name:
    Zinc finger protein 37 homolog
    Protein Accession:
    Q9Y6Q3
    Secondary Accessions:
    • A0AVJ9
    • B4DVX4
    • G3V3L7
    • Q5T7Q4

    Protein attributes for ZFP37 Gene

    Size:
    630 amino acids
    Molecular mass:
    71209 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZFP37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP37 Gene

Post-translational modifications for ZFP37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP37 Gene

No data available for DME Specific Peptides for ZFP37 Gene

Domains & Families for ZFP37 Gene

Gene Families for ZFP37 Gene

Protein Domains for ZFP37 Gene

Suggested Antigen Peptide Sequences for ZFP37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6Q3

UniProtKB/Swiss-Prot:

ZFP37_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFP37: view

Function for ZFP37 Gene

Molecular function for ZFP37 Gene

GENATLAS Biochemistry:
zinc finger protein 37,with a Kruppel-associated box domain (KRAB domain),expressed in fetal cartilage
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZFP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 9585434
GO:0008270 zinc ion binding NAS 9585434
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP37: view
genes like me logo Genes that share phenotypes with ZFP37: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP37 Gene

Localization for ZFP37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP37 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP37 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZFP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP37: view

Pathways & Interactions for ZFP37 Gene

SuperPathways for ZFP37 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP37: view

Pathways by source for ZFP37 Gene

2 Reactome pathways for ZFP37 Gene

Interacting Proteins for ZFP37 Gene

Gene Ontology (GO) - Biological Process for ZFP37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 9585434
genes like me logo Genes that share ontologies with ZFP37: view

No data available for SIGNOR curated interactions for ZFP37 Gene

Transcripts for ZFP37 Gene

mRNA/cDNA for ZFP37 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP37 Gene

ZFP37 zinc finger protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP37 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for ZFP37 Gene

GeneLoc Exon Structure for
ZFP37
ECgene alternative splicing isoforms for
ZFP37

Expression for ZFP37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFP37 Gene

Protein differential expression in normal tissues from HIPED for ZFP37 Gene

This gene is overexpressed in Ovary (50.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFP37 Gene



Protein tissue co-expression partners for ZFP37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFP37 Gene:

ZFP37

SOURCE GeneReport for Unigene cluster for ZFP37 Gene:

Hs.150406

mRNA Expression by UniProt/SwissProt for ZFP37 Gene:

Q9Y6Q3-ZFP37_HUMAN
Tissue specificity: Expressed at low level in several tissues including fetal cartilage.
genes like me logo Genes that share expression patterns with ZFP37: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZFP37 Gene

Orthologs for ZFP37 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFP37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP37 34 35
  • 99.11 (n)
dog
(Canis familiaris)
Mammalia ZFP37 34 35
  • 88.04 (n)
cow
(Bos Taurus)
Mammalia ZFP37 34
  • 87.59 (n)
-- 35
  • 53 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp37 34 16 35
  • 80.73 (n)
rat
(Rattus norvegicus)
Mammalia Zfp37 34
  • 77.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 56 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Kr-h1 36
  • 50 (a)
CG9650 36
  • 45 (a)
dwg 36
  • 44 (a)
CG12299 36
  • 42 (a)
CG3407 36
  • 38 (a)
CG7963 36
  • 36 (a)
Neu2 36
  • 32 (a)
Species where no ortholog for ZFP37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP37 Gene

ENSEMBL:
Gene Tree for ZFP37 (if available)
TreeFam:
Gene Tree for ZFP37 (if available)

Paralogs for ZFP37 Gene

(535) SIMAP similar genes for ZFP37 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZFP37 Gene

genes like me logo Genes that share paralogs with ZFP37: view

Variants for ZFP37 Gene

Sequence variations from dbSNP and Humsavar for ZFP37 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs202181932 Uncertain significance 113,056,670(+) CTGGA(C/G/T)GCCGC reference, missense
rs10817437 -- 113,052,193(+) TGCTT(C/T)ACCTG intron-variant
rs10981619 -- 113,041,555(+) ATTCA(A/T)CATCA downstream-variant-500B
rs10981620 -- 113,045,693(+) TGGAC(C/T)GTGGT intron-variant
rs10981621 -- 113,053,118(+) tcact(A/G)tacca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP37 Gene

Variant ID Type Subtype PubMed ID
nsv8562 CNV gain+loss 18304495
nsv831691 CNV loss 17160897
nsv6672 CNV deletion 18451855
nsv615204 CNV loss 21841781
nsv525545 CNV gain 19592680
nsv517282 CNV loss 19592680
nsv510987 OTHER complex 20534489
nsv509318 CNV insertion 20534489
nsv508563 CNV deletion 20534489
nsv466491 CNV loss 19166990
nsv1161899 CNV deletion 26073780
nsv1128515 CNV deletion 24896259
nsv1037784 CNV loss 25217958
esv3891713 CNV loss 25118596
esv3891712 CNV loss 25118596
esv3621528 CNV gain 21293372
esv3621527 CNV loss 21293372
esv3621526 CNV gain 21293372
esv3573363 CNV loss 25503493
esv2764155 CNV loss 21179565
esv2759710 CNV gain 17122850
dgv943n27 CNV loss 19166990
dgv12853n54 CNV loss 21841781
dgv1232n67 CNV gain 20364138

Variation tolerance for ZFP37 Gene

Residual Variation Intolerance Score: 45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP37 Gene

Disorders for ZFP37 Gene

Relevant External Links for ZFP37

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP37

No disorders were found for ZFP37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP37 Gene

Publications for ZFP37 Gene

  1. Cloning, characterization, and chromosomal assignment of the human ortholog of murine Zfp-37, a candidate gene for Nager syndrome. (PMID: 9585434) Dreyer S.D. … Lee B. (Mamm. Genome 1998) 3 4 64
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for ZFP37 Gene

Sources for ZFP37 Gene

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