Aliases for ZFP36L2 Gene
External Ids for ZFP36L2 Gene
Previous HGNC Symbols for ZFP36L2 Gene
Previous GeneCards Identifiers for ZFP36L2 Gene
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZFP36L2 Gene
ZFP36L2 (ZFP36 Ring Finger Protein-Like 2) is a Protein Coding gene. Diseases associated with ZFP36L2 include acute t cell leukemia. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include poly(A) RNA binding and AU-rich element binding. An important paralog of this gene is ZFP36.
UniProtKB/Swiss-Prot for ZFP36L2 Gene
mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity).