ZFP36L2 Gene
protein-coding GIFtS: 48
GCID: GC02M043449
|
|
ZFP36 ring finger protein-like 2(Previous names: zinc finger protein 36, C3H type-like 1, zinc finger protein...)
(Previous symbol: BRF2)
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Aliases
for ZFP36L2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ZFP36 Ring Finger Protein-Like 21 2 | | Butyrate Response Factor 22 3 | | ERF21 2 3 5 | | ERF-22 3 | | TIS11D1 2 3 5 | | EGF-Response Factor 22 3 | | BRF21 2 3 | | ZFP36-Like 22 3 | | RNF162C1 2 3 | | Zinc Finger Protein 36, C3H1 Type-Like 22 | | Zinc Finger Protein 36, C3H Type-Like 11 2 | | Zinc Finger Protein, C3H Type, 36-Like 22 | | Zinc Finger Protein 36, C3H Type-Like 21 2 | | Protein TIS11D3 |
Export aliases for ZFP36L2 gene to outside databasesPrevious GC identifers: GC02M043619 GC02M043425 GC02M043362 GC02M043304 GC02M043184 |
Summaries
for ZFP36L2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZFP36L2:
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists suchas the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zincfinger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions inregulating the response to growth factors. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TISD_HUMAN, P47974Function: Probable regulatory protein involved in regulating the response to growth factors. RNA-binding protein thatbinds to 5'UUAUUUAUUU-3' core sequence. Binds to the class II AU-rich element (ARE) in the 3'-UTR of target mRNAs andpromotes their deadenylation and degradation
|
Genomic Views
for ZFP36L2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZFP36L2 gene promoter:
E2F-4 E2F-3a E2F-5 Pax-5 Nkx2-5 E2F-2 E2F E2F-1 FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZFP36L2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP36L2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p22.3-p21 Ensembl cytogenetic band: 2p21 HGNC cytogenetic band: 2p22.3-p21ZFP36L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M043449: view genomic region
(about GC identifiers)
Start:
|
43,449,541 bp from pter |
End:
|
43,453,748 bp from pter |
Size:
|
4,208 bases |
Orientation:
|
minus strand |
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Proteins
for ZFP36L2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TISD_HUMAN, P47974 (See
protein sequence)Recommended Name: Zinc finger protein 36, C3H1 type-like 2 Size: 494 amino acids; 51063 Da
Subcellular location: Nucleus (Potential)
1 PDB 3D structure from  and Proteopedia  for ZFP36L2:1RGO (3D)
Secondary accessions: Q53TB4 Q9BSJ3Explore the universe of human proteins at neXtProt for ZFP36L2: NX_P47974
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P47974
ZFP36L2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_008818.3
ENSEMBL proteins: ENSP00000282388
Human Recombinant Protein Products for ZFP36L2:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZFP36L2 for ontologies About GeneDecksing
ZFP36L2 Antibody Products:
Assay Products for ZFP36L2: |
Protein
Domains /
Families
for ZFP36L2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZFP36L2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P47974ProtoNet protein and cluster: P47974 2 Blocks protein families: IPB000571 Zn-finger IPB007635 Tis11B like protein
UniProtKB/Swiss-Prot: TISD_HUMAN, P47974Similarity: Contains 2 C3H1-type zinc fingers |
Function
for ZFP36L2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TISD_HUMAN, P47974Function: Probable regulatory protein involved in regulating the response to growth factors. RNA-binding protein thatbinds to 5'UUAUUUAUUU-3' core sequence. Binds to the class II AU-rich element (ARE) in the 3'-UTR of target mRNAs andpromotes their deadenylation and degradation Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZFP36L2 for ontologies About GeneDecksing
Phenotypes:
13 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Zfp36l2):
ZFP36L2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for ZFP36L2: Zfp36l2tm1Pjb Zfp36l2tm2Pjb
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP36L2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP36L2 |
|
Pathways & Interactions
for ZFP36L2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFP36L2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZFP36L2 (P479743 ENSP000002823884) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
TAS | 7835719 | | GO:0008283 | cell proliferation |
TAS | 7835719 | | GO:0043488 | regulation of mRNA stability |
IEA | -- |
ZFP36L2 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZFP36L2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ZFP36L2 for compounds About GeneDecksing
 Browse Tocris compounds for ZFP36L2
2 Novoseek chemical compound relationships for ZFP36L2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 12-o-tetradecanoylphorbol 13-acetate |
51.1 |
2 |
7615073 (1), 1996120 (1) |
| zinc |
49 |
3 |
14981510 (3) |
Search CenterWatch for drugs/clinical trials and news about ZFP36L2 / TISD
|
Transcripts
for ZFP36L2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZFP36L2 gene: NM_006887.4 Unigene Cluster for ZFP36L2: ZFP36 ring finger protein-like 2 Hs.503093 [show with all ESTs]Unigene Representative Sequence: NM_0068871 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000282388(uc002rsv.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP36L2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP36L2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZFP36L2 (NM_006887) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: BC005010.1 BC020369.1 X78992.1 22 DOTS entries: DT.91886932 DT.92459208 DT.95221570 DT.92459214 DT.92370510 DT.100807622 DT.100877206 DT.95108247 DT.120935730 DT.100877200 DT.100877205 DT.120935749 DT.75100380 DT.92459212 DT.95183890 DT.100684899 DT.120935737 DT.95118288 DT.95221571 DT.95250020 DT.97763135 DT.95287694 24/223 AceView cDNA sequences (see all 223): CD671527 NM_006887 AA302841 BQ271279 BF062350 CK819088 AI972485 BE645759 AI652878 AI302137 BI819830 BC020369 AW136034 CA423901 AW008142 BG390839 BQ270986 CD251448 AI640912 BM719211 BU070641 H22216 CK819089 AW070848
GeneLoc Exon Structure
|
Expression
for ZFP36L2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZFP36L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGAAAGGCA
About this image
See ZFP36L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZFP36L2
SOURCE GeneReport for Unigene cluster: Hs.503093
SABiosciences Custom PCR Arrays for ZFP36L2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFP36L2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP36L2 |
Orthologs
for ZFP36L2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZFP36L2 gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
ZFP36L26 |
-- |
64(a) |
1 ↔ 1 |
GL343231.1(1495538-1499017) |
African clawed frog
(Xenopus laevis) |
Amphibia |
zfp36l2-prov2 |
zinc finger protein 36, C3H type-like 2 |
77.42(n) |
|
BC044086.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zfp36l21 |
zinc finger protein 36, C3H type-like 2 |
62.77(n)
63.23(a) |
|
333941 NM_207055.1 NP_996938.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Tis113 |
DNA binding |
81(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
ccch-26ccch-56(see all 15) |
CCCH-type zinc finger transcription factor family ...CCCH-type zinc finger transcription factor family ...(see all 15) |
23(a)21(a)(see all 15) |
possible orthologpossible ortholog(see all 15) |
IV(16278181-16278986) IV(14919592-14920391) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G668106AT1G682006 |
zinc finger CCCH domain-containing protein 15 |
16(a)16(a) |
many ↔ manymany ↔ many |
1(24927613-24928803) 1(25562118-25563948) |
rice
(Oryza sativa) |
Liliopsida |
AK068034.12 |
-- |
73.02(n) |
|
AK068034.1 |
ENSEMBL Gene Tree for ZFP36L2 (if available)
TreeFam Gene Tree for ZFP36L2 (if available) |
Paralogs
for ZFP36L2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZFP36L2 gene
- ZFP36L12 ZFP362
ZFP36L2 for paralogs About GeneDecksing
|
Genomic Variants
for ZFP36L2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZFP36L2 (43449541 - 43453748 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZFP36L2
1 CNV: 73419 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFP36L2 |
|
Disorders
/ Diseases
for ZFP36L2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZFP36L2 for disorders About GeneDecksing
OMIM gene information: 612053
OMIM disorders: --
13  diseases for ZFP36L2: About MalaCardspolycystic ovary syndrome papillary thyroid carcinoma folliculitis renal cell carcinoma
thyroid carcinoma t-cell leukemia acute t cell leukemia acute leukemia
thyroiditis leukemia colorectal cancer carcinoma
hypoxia
Export disorders for ZFP36L2 gene to outside databases
|
Publications
for ZFP36L2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZFP36L2 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with ZFP36L2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. (PubMed id 14981510)1, 2, 3, 9 Hudson B.P....Wright P.E. (2004)
- Identification of a member of the TIS11 early response gene family at the insertion point of a DNA fragment containing a gene for the T-cell receptor beta chain in an acute T-cell leukemia. (PubMed id 8545129)1, 2, 3, 9 Ino T.... Kurosawa Y. (1995)
- ERF-2, the human homologue of the murine Tis11d early response gene. (PubMed id 7835719)1, 2, 3 Nie X.F.... Bustin S.A. (1995)
- TIS11D is a candidate pro-apoptotic p53 target gene. (PubMed id 17172869)1, 3 Jackson R.S....Liang P. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Polymorphisms in the genes encoding members of the tristetraprolin family of human tandem CCCH zinc finger proteins. (PubMed id 14604009)1, 9 Blackshear P.J....Mohrenweiser H. (2003)
- Genome-wide association study identifies susceptibili ty loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. (PubMed id 21151128)1 Chen Z.J....Zhao Y. (2011)
- The roles of TTP and BRF proteins in regulated mRNA de cay. (PubMed id 21278925)1 Sanduja S....Dixon D.A. (2011)
- Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia. (PubMed id 21109922)1 Iwanaga E....Asou N. (2011)
- Differential expression of a set of genes in follicul ar and classic variants of papillary thyroid carcinoma. (PubMed id 21509594)1 Igci Y.Z....Demiryurek A.T. (2011)
|
External Searches for ZFP36L2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZFP36L2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZFP36L2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZFP36L2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZFP36L2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZFP36L2 gene:
Search GeneIP for patents involving ZFP36L2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZFP36L2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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