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Aliases for ZFP36L2 Gene

Aliases for ZFP36L2 Gene

  • ZFP36 Ring Finger Protein-Like 2 2 3
  • TIS11D 3 4 6
  • ERF2 3 4 6
  • Zinc Finger Protein 36, C3H Type-Like 1 2 3
  • Zinc Finger Protein 36, C3H Type-Like 2 2 3
  • Butyrate Response Factor 2 3 4
  • EGF-Response Factor 2 3 4
  • ZFP36-Like 2 3 4
  • RNF162C 3 4
  • ERF-2 3 4
  • BRF2 3 4
  • Zinc Finger Protein 36, C3H1 Type-Like 2 3
  • Zinc Finger Protein, C3H Type, 36-Like 2 3
  • Protein TIS11D 4

External Ids for ZFP36L2 Gene

Previous Symbols for ZFP36L2 Gene

  • BRF2

Summaries for ZFP36L2 Gene

Entrez Gene Summary for ZFP36L2 Gene

  • This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZFP36L2 Gene

ZFP36L2 (ZFP36 Ring Finger Protein-Like 2) is a Protein Coding gene. Among its related pathways are Translational Control and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and AU-rich element binding. An important paralog of this gene is ZFP36.

UniProtKB/Swiss-Prot for ZFP36L2 Gene

  • mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP36L2 Gene

Genomics for ZFP36L2 Gene

Genomic Location for ZFP36L2 Gene

Start:
43,222,402 bp from pter
End:
43,226,609 bp from pter
Size:
4,208 bases
Orientation:
Minus strand

Genomic View for ZFP36L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFP36L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP36L2 Gene

Regulatory Elements for ZFP36L2 Gene

Proteins for ZFP36L2 Gene

  • Protein details for ZFP36L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47974-TISD_HUMAN
    Recommended name:
    Zinc finger protein 36, C3H1 type-like 2
    Protein Accession:
    P47974
    Secondary Accessions:
    • Q53TB4
    • Q9BSJ3

    Protein attributes for ZFP36L2 Gene

    Size:
    494 amino acids
    Molecular mass:
    51063 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZFP36L2 Gene

neXtProt entry for ZFP36L2 Gene

Proteomics data for ZFP36L2 Gene at MOPED

Post-translational modifications for ZFP36L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP36L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFP36L2 Gene

Domains for ZFP36L2 Gene

Gene Families for ZFP36L2 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for ZFP36L2 Gene

UniProtKB/Swiss-Prot:

TISD_HUMAN
Similarity:
  • Contains 2 C3H1-type zinc fingers.:
    • P47974
genes like me logo Genes that share domains with ZFP36L2: view

Function for ZFP36L2 Gene

Molecular function for ZFP36L2 Gene

UniProtKB/Swiss-Prot Function: mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for ZFP36L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 7835719
GO:0017091 AU-rich element binding IDA 20506496
GO:0035925 mRNA 3-UTR AU-rich region binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZFP36L2: view
genes like me logo Genes that share phenotypes with ZFP36L2: view

Animal Models for ZFP36L2 Gene

MGI Knock Outs for ZFP36L2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZFP36L2 Gene

Localization for ZFP36L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP36L2 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP36L2 Gene COMPARTMENTS Subcellular localization image for ZFP36L2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZFP36L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with ZFP36L2: view

Pathways for ZFP36L2 Gene

genes like me logo Genes that share pathways with ZFP36L2: view

Gene Ontology (GO) - Biological Process for ZFP36L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 7835719
GO:0006402 mRNA catabolic process ISS --
GO:0008283 cell proliferation TAS 7835719
GO:0030097 hemopoiesis ISS --
genes like me logo Genes that share ontologies with ZFP36L2: view

Compounds for ZFP36L2 Gene

(2) Novoseek inferred chemical compound relationships for ZFP36L2 Gene

Compound -log(P) Hits PubMed IDs
12-o-tetradecanoylphorbol 13-acetate 51.1 2
zinc 49 3
genes like me logo Genes that share compounds with ZFP36L2: view

Transcripts for ZFP36L2 Gene

mRNA/cDNA for ZFP36L2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(223) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP36L2 Gene

ZFP36 ring finger protein-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP36L2 Gene

No ASD Table

Relevant External Links for ZFP36L2 Gene

GeneLoc Exon Structure for
ZFP36L2
ECgene alternative splicing isoforms for
ZFP36L2

Expression for ZFP36L2 Gene

mRNA expression in normal human tissues for ZFP36L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFP36L2 Gene

SOURCE GeneReport for Unigene cluster for ZFP36L2 Gene Hs.503093

genes like me logo Genes that share expressions with ZFP36L2: view

Orthologs for ZFP36L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFP36L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP36L2 36
  • 99.19 (n)
  • 100 (a)
ZFP36L2 37
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFP36L2 36
  • 87.01 (n)
  • 89.69 (a)
ZFP36L2 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP36L2 36
  • 91.08 (n)
  • 92.8 (a)
ZFP36L2 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp36l2 36
  • 87.71 (n)
  • 89.37 (a)
Zfp36l2 16
Zfp36l2 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFP36L2 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFP36L2 37
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911319 36
  • 88.38 (n)
  • 92.53 (a)
lizard
(Anolis carolinensis)
Reptilia ZFP36L2 37
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia zfp36l2-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4111 36
zfp36l2 36
  • 72.66 (n)
  • 77.97 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8295 36
zebrafish
(Danio rerio)
Actinopterygii zfp36l2 36
  • 64.86 (n)
  • 68.78 (a)
zfp36l2 37
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tis11 37
  • 25 (a)
OneToMany
Tis11 38
  • 81 (a)
worm
(Caenorhabditis elegans)
Secernentea C35D6.4 37
  • 26 (a)
ManyToMany
ccch-1 37
  • 21 (a)
ManyToMany
ccch-2 37
  • 27 (a)
ManyToMany
ccch-5 37
  • 24 (a)
ManyToMany
dct-13 37
  • 24 (a)
ManyToMany
F38C2.7 37
  • 25 (a)
ManyToMany
mex-1 37
  • 16 (a)
ManyToMany
pos-1 37
  • 20 (a)
ManyToMany
Y116A8C.19 37
  • 25 (a)
ManyToMany
Y116A8C.20 37
  • 23 (a)
ManyToMany
Y60A9.3 37
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTH1 37
  • 18 (a)
ManyToMany
CTH1 39
TIS11 37
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6084 37
  • 32 (a)
OneToMany
Species with no ortholog for ZFP36L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFP36L2 Gene

ENSEMBL:
Gene Tree for ZFP36L2 (if available)
TreeFam:
Gene Tree for ZFP36L2 (if available)

Paralogs for ZFP36L2 Gene

Paralogs for ZFP36L2 Gene

genes like me logo Genes that share paralogs with ZFP36L2: view

Variants for ZFP36L2 Gene

Sequence variations from dbSNP and Humsavar for ZFP36L2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7933 -- 43,225,044(+) GTGCA(A/G)CTTGG synonymous-codon, reference
rs8098 -- 43,225,195(-) ACCAT(C/G/T)GGCTT reference, missense, synonymous-codon
rs9170 -- 43,222,999(-) ACTAG(C/T)AAAAA utr-variant-3-prime
rs762603 -- 43,225,105(-) GACCT(G/T)CGTGC reference, synonymous-codon
rs1050381 -- 43,224,786(-) GGGGC(G/T)CCGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZFP36L2 Gene

Variant ID Type Subtype PubMed ID
nsv829097 CNV Gain 20364138
esv25646 CNV Loss 19812545

Relevant External Links for ZFP36L2 Gene

HapMap Linkage Disequilibrium report
ZFP36L2

Disorders for ZFP36L2 Gene

UniProtKB/Swiss-Prot

TISD_HUMAN
  • Note=Defects in ZFP36L2 may be a cause of leukemias. Frameshfits mutations disrupting ZFP36L2 have been found in a patient with acute myeloid leukemia (PubMed:21109922). {ECO:0000269 PubMed:21109922}.

No disorders were found for ZFP36L2 Gene.

Publications for ZFP36L2 Gene

  1. Identification of a member of the TIS11 early response gene family at the insertion point of a DNA fragment containing a gene for the T-cell receptor beta chain in an acute T-cell leukemia. (PMID: 8545129) Ino T. … Kurosawa Y. (Oncogene 1995) 2 3 4 23
  2. Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. (PMID: 14981510) Hudson B.P. … Wright P.E. (Nat. Struct. Mol. Biol. 2004) 2 3 4 23
  3. ERF-2, the human homologue of the murine Tis11d early response gene. (PMID: 7835719) Nie X.F. … Bustin S.A. (Gene 1995) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. TIS11D is a candidate pro-apoptotic p53 target gene. (PMID: 17172869) Jackson R.S. … Liang P. (Cell Cycle 2006) 2 3

Products for ZFP36L2 Gene

Sources for ZFP36L2 Gene

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