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Aliases for ZFP36L2 Gene

Aliases for ZFP36L2 Gene

  • ZFP36 Ring Finger Protein-Like 2 2 3 5
  • Zinc Finger Protein 36, C3H Type-Like 1 2 3
  • Zinc Finger Protein 36, C3H Type-Like 2 2 3
  • Butyrate Response Factor 2 3 4
  • EGF-Response Factor 2 3 4
  • ZFP36-Like 2 3 4
  • RNF162C 3 4
  • TIS11D 3 4
  • ERF-2 3 4
  • BRF2 3 4
  • ERF2 3 4
  • Zinc Finger Protein, C3H Type, 36-Like 2 3
  • Protein TIS11D 4

External Ids for ZFP36L2 Gene

Previous HGNC Symbols for ZFP36L2 Gene

  • BRF2

Previous GeneCards Identifiers for ZFP36L2 Gene

  • GC02M043449
  • GC02M043619
  • GC02M043425
  • GC02M043362
  • GC02M043304

Summaries for ZFP36L2 Gene

Entrez Gene Summary for ZFP36L2 Gene

  • This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZFP36L2 Gene

ZFP36L2 (ZFP36 Ring Finger Protein-Like 2) is a Protein Coding gene. Diseases associated with ZFP36L2 include acute t cell leukemia. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include poly(A) RNA binding and AU-rich element binding. An important paralog of this gene is ZFP36.

UniProtKB/Swiss-Prot for ZFP36L2 Gene

  • mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP36L2 Gene

Genomics for ZFP36L2 Gene

Regulatory Elements for ZFP36L2 Gene

Genomic Location for ZFP36L2 Gene

Chromosome:
2
Start:
43,222,402 bp from pter
End:
43,226,609 bp from pter
Size:
4,208 bases
Orientation:
Minus strand

Genomic View for ZFP36L2 Gene

Genes around ZFP36L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP36L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP36L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP36L2 Gene

Proteins for ZFP36L2 Gene

  • Protein details for ZFP36L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47974-TISD_HUMAN
    Recommended name:
    Zinc finger protein 36, C3H1 type-like 2
    Protein Accession:
    P47974
    Secondary Accessions:
    • Q53TB4
    • Q9BSJ3

    Protein attributes for ZFP36L2 Gene

    Size:
    494 amino acids
    Molecular mass:
    51063 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZFP36L2 Gene

neXtProt entry for ZFP36L2 Gene

Proteomics data for ZFP36L2 Gene at MOPED

Post-translational modifications for ZFP36L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP36L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZFP36L2 Gene

Domains & Families for ZFP36L2 Gene

Gene Families for ZFP36L2 Gene

Protein Domains for ZFP36L2 Gene

Suggested Antigen Peptide Sequences for ZFP36L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47974

UniProtKB/Swiss-Prot:

TISD_HUMAN :
  • Contains 2 C3H1-type zinc fingers.
Similarity:
  • Contains 2 C3H1-type zinc fingers.
genes like me logo Genes that share domains with ZFP36L2: view

Function for ZFP36L2 Gene

Molecular function for ZFP36L2 Gene

UniProtKB/Swiss-Prot Function:
mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for ZFP36L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZFP36L2: view
genes like me logo Genes that share phenotypes with ZFP36L2: view

Animal Models for ZFP36L2 Gene

MGI Knock Outs for ZFP36L2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZFP36L2 Gene

Localization for ZFP36L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP36L2 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250 UniProtKB:P23949}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP36L2 Gene COMPARTMENTS Subcellular localization image for ZFP36L2 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZFP36L2 Gene

Pathways & Interactions for ZFP36L2 Gene

genes like me logo Genes that share pathways with ZFP36L2: view

Gene Ontology (GO) - Biological Process for ZFP36L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 7835719
GO:0006402 mRNA catabolic process IEA,ISS --
GO:0008283 cell proliferation TAS 7835719
GO:0033077 T cell differentiation in thymus IEA --
genes like me logo Genes that share ontologies with ZFP36L2: view

No data available for SIGNOR curated interactions for ZFP36L2 Gene

Drugs & Compounds for ZFP36L2 Gene

(1) Drugs for ZFP36L2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ZFP36L2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZFP36L2: view

Transcripts for ZFP36L2 Gene

mRNA/cDNA for ZFP36L2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(223) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP36L2 Gene

ZFP36 ring finger protein-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP36L2 Gene

No ASD Table

Relevant External Links for ZFP36L2 Gene

GeneLoc Exon Structure for
ZFP36L2
ECgene alternative splicing isoforms for
ZFP36L2

Expression for ZFP36L2 Gene

mRNA expression in normal human tissues for ZFP36L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFP36L2 Gene

This gene is overexpressed in Testis (27.4), CD8 Tcells (13.0), and Adipocyte (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFP36L2 Gene



SOURCE GeneReport for Unigene cluster for ZFP36L2 Gene Hs.503093

genes like me logo Genes that share expression patterns with ZFP36L2: view

Protein tissue co-expression partners for ZFP36L2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFP36L2 Gene

Orthologs for ZFP36L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFP36L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZFP36L2 35
  • 87.01 (n)
  • 89.69 (a)
ZFP36L2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP36L2 35
  • 91.08 (n)
  • 92.8 (a)
ZFP36L2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp36l2 35
  • 87.71 (n)
  • 89.37 (a)
Zfp36l2 16
Zfp36l2 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZFP36L2 35
  • 99.19 (n)
  • 100 (a)
ZFP36L2 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911319 35
  • 88.38 (n)
  • 92.53 (a)
oppossum
(Monodelphis domestica)
Mammalia ZFP36L2 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFP36L2 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFP36L2 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4111 35
zfp36l2 35
  • 72.66 (n)
  • 77.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia zfp36l2-prov 35
zebrafish
(Danio rerio)
Actinopterygii zfp36l2 35
  • 64.86 (n)
  • 68.78 (a)
zfp36l2 36
  • 50 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8295 35
fruit fly
(Drosophila melanogaster)
Insecta Tis11 37
  • 81 (a)
Tis11 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C35D6.4 36
  • 26 (a)
ManyToMany
ccch-1 36
  • 21 (a)
ManyToMany
ccch-2 36
  • 27 (a)
ManyToMany
ccch-5 36
  • 24 (a)
ManyToMany
dct-13 36
  • 24 (a)
ManyToMany
F38C2.7 36
  • 25 (a)
ManyToMany
mex-1 36
  • 16 (a)
ManyToMany
pos-1 36
  • 20 (a)
ManyToMany
Y116A8C.19 36
  • 25 (a)
ManyToMany
Y116A8C.20 36
  • 23 (a)
ManyToMany
Y60A9.3 36
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTH1 36
  • 18 (a)
ManyToMany
TIS11 36
  • 17 (a)
ManyToMany
CTH1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6084 36
  • 32 (a)
OneToMany
Species with no ortholog for ZFP36L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFP36L2 Gene

ENSEMBL:
Gene Tree for ZFP36L2 (if available)
TreeFam:
Gene Tree for ZFP36L2 (if available)

Paralogs for ZFP36L2 Gene

Paralogs for ZFP36L2 Gene

genes like me logo Genes that share paralogs with ZFP36L2: view

Variants for ZFP36L2 Gene

Sequence variations from dbSNP and Humsavar for ZFP36L2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs7933 -- 43,225,044(+) GTGCA(A/G)CTTGG reference, synonymous-codon
rs8098 -- 43,225,195(-) ACCAT(C/G/T)GGCTT reference, synonymous-codon
rs9170 -- 43,222,999(-) ACTAG(C/T)AAAAA utr-variant-3-prime
rs762603 -- 43,225,105(-) GACCT(G/T)CGTGC reference, synonymous-codon
rs1050381 -- 43,224,786(-) GGGGC(G/T)CCGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZFP36L2 Gene

Variant ID Type Subtype PubMed ID
nsv829097 CNV Gain 20364138
esv25646 CNV Loss 19812545

Variation tolerance for ZFP36L2 Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.35; 70.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP36L2 Gene

HapMap Linkage Disequilibrium report
ZFP36L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP36L2 Gene

Disorders for ZFP36L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFP36L2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute t cell leukemia
  • precursor t lymphoblastic leukemia
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TISD_HUMAN
  • Note=Defects in ZFP36L2 may be a cause of leukemias. Frameshfits mutations disrupting ZFP36L2 have been found in a patient with acute myeloid leukemia (PubMed:21109922). {ECO:0000269 PubMed:21109922}.

Relevant External Links for ZFP36L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP36L2
genes like me logo Genes that share disorders with ZFP36L2: view

No data available for Genatlas for ZFP36L2 Gene

Publications for ZFP36L2 Gene

  1. Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. (PMID: 14981510) Hudson B.P. … Wright P.E. (Nat. Struct. Mol. Biol. 2004) 2 3 4 23 67
  2. Identification of a member of the TIS11 early response gene family at the insertion point of a DNA fragment containing a gene for the T-cell receptor beta chain in an acute T-cell leukemia. (PMID: 8545129) Ino T. … Kurosawa Y. (Oncogene 1995) 2 3 23
  3. TIS11D is a candidate pro-apoptotic p53 target gene. (PMID: 17172869) Jackson R.S. … Liang P. (Cell Cycle 2006) 2 3
  4. Polymorphisms in the genes encoding members of the tristetraprolin family of human tandem CCCH zinc finger proteins. (PMID: 14604009) Blackshear P.J. … Mohrenweiser H. (Prog. Nucleic Acid Res. Mol. Biol. 2003) 3 23
  5. ERF-2, the human homologue of the murine Tis11d early response gene. (PMID: 7835719) Nie X.F. … Bustin S.A. (Gene 1995) 2 3

Products for ZFP36L2 Gene

Sources for ZFP36L2 Gene

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