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ZFP36L2 Gene

protein-coding   GIFtS: 50
GCID: GC02M043449

ZFP36 Ring Finger Protein-Like 2

(Previous names: zinc finger protein 36, C3H type-like 1, zinc finger protein...)
(Previous symbol: BRF2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ZFP36 Ring Finger Protein-Like 21 2     ERF-22 3
BRF21 2 3     RNF162C2 3
ERF22 3 5     EGF-Response Factor 22 3
TIS11D2 3 5     ZFP36-Like 22 3
Zinc Finger Protein 36, C3H Type-Like 11 2     Zinc Finger Protein 36, C3H1 Type-Like 22
Zinc Finger Protein 36, C3H Type-Like 21 2     Zinc Finger Protein, C3H Type, 36-Like 22
Butyrate Response Factor 22 3     Protein TIS11D3

External Ids:    HGNC: 11081   Entrez Gene: 6782   Ensembl: ENSG000001525187   OMIM: 6120535   UniProtKB: P479743   

Export aliases for ZFP36L2 gene to outside databases

Previous GC identifers: GC02M043619 GC02M043425 GC02M043362 GC02M043304 GC02M043184


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZFP36L2 Gene:
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists
such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing
putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most
likely functions in regulating the response to growth factors. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZFP36L2 Gene:
ZFP36L2 (ZFP36 ring finger protein-like 2) is a protein-coding gene. Diseases associated with ZFP36L2 include folliculitis, and papillary thyroid carcinoma. GO annotations related to this gene include AU-rich element binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZFP36L1.

UniProtKB/Swiss-Prot: TISD_HUMAN, P47974
Function: mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to
glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their
deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E)
progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation:
promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal
erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation.
Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal
differentiation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFP36L2 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   Nkx2-5   E2F-2   E2F   E2F-1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZFP36L2 promoter sequence
   Search Chromatin IP Primers for ZFP36L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFP36L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.3-p21   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p22.3-p21

ZFP36L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP36L2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M043449:  view genomic region     (about GC identifiers)

Start:
43,449,541 bp from pter      End:
43,453,748 bp from pter
Size:
4,208 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TISD_HUMAN, P47974 (See protein sequence)
Recommended Name: Zinc finger protein 36, C3H1 type-like 2  
Size: 494 amino acids; 51063 Da
1 PDB 3D structure from and Proteopedia for ZFP36L2:
1RGO (3D)    
Secondary accessions: Q53TB4 Q9BSJ3

Explore the universe of human proteins at neXtProt for ZFP36L2: NX_P47974

Explore proteomics data for ZFP36L2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZFP36L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008818.3  
    ENSEMBL proteins: 
     ENSP00000282388  

    ZFP36L2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR007635 Tis11B_N

    Graphical View of Domain Structure for InterPro Entry P47974

    ProtoNet protein and cluster: P47974

    2 Blocks protein domains:
    IPB000571 Zn-finger
    IPB007635 Tis11B like protein


    UniProtKB/Swiss-Prot: TISD_HUMAN, P47974
    Similarity: Contains 2 C3H1-type zinc fingers


    ZFP36L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TISD_HUMAN, P47974
    Function: mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to
    glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their
    deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E)
    progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation:
    promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal
    erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation.
    Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal
    differentiation (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS7835719
    GO:0017091AU-rich element binding IDA--
    GO:0035925mRNA 3'-UTR AU-rich region binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    ZFP36L2 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Zfp36l2):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size/body 
     hematopoietic system  immune system  integument  liver/biliary system  mortality/aging 
     renal/urinary system  reproductive system  tumorigenesis 

    ZFP36L2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ZFP36L2: Zfp36l2tm1Pjb Zfp36l2tm2Pjb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZFP36L2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZFP36L2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZFP36L2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZFP36L2:
    hsa-mir-18a-5p (MIRT050676), hsa-mir-421 (MIRT016129), hsa-mir-181a-5p (MIRT047326), hsa-mir-375 (MIRT019787), hsa-mir-124-3p (MIRT002907), hsa-mir-671-5p (MIRT039272), hsa-mir-186-5p (MIRT045099)

    Block miRNA regulation of human, mouse, rat ZFP36L2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFP36L2 (see all 60):
    hsa-miR-128 hsa-miR-30d hsa-miR-371-5p hsa-miR-124 hsa-miR-30a hsa-miR-186 hsa-miR-506 hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidZFP36L2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZFP36L2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ZFP36L2 (NM_006887)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP36L2

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    Browse ESI BIO Cell Lines and PureStem Progenitors for ZFP36L2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP36L2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TISD_HUMAN, P47974: Cytoplasm (By similarity). Nucleus (By similarity). Note=Shuttles between the nucleus and
    the cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--

    ZFP36L2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ZFP36L2
        Transcription of tRNA
    Assembly of RNA Polymerase-III Initiation Complex


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFP36L2
    Interactions:

        GeneGlobe Interaction Network for ZFP36L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZFP36L2 (P479743 ENSP000002823884) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAHQ049173, ENSP000002489754I2D: score=1 STRING: ENSP00000248975
    PIN1ENSP000002479704STRING: ENSP00000247970
    DDX6ENSP000002640184STRING: ENSP00000264018
    KIAA2013ENSP000003657564STRING: ENSP00000365756
    FNTBENSP000002461664STRING: ENSP00000246166
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA--
    GO:0006355regulation of transcription, DNA-templated TAS7835719
    GO:0006402mRNA catabolic process ISS--
    GO:0008283cell proliferation TAS7835719
    GO:0030097hemopoiesis ISS--

    ZFP36L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFP36L2 (TISD)

    2 Novoseek inferred chemical compound relationships for ZFP36L2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    12-o-tetradecanoylphorbol 13-acetate 51.1 2 7615073 (1), 1996120 (1)
    zinc 49 3 14981510 (3)



    ZFP36L2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZFP36L2 gene: 
    NM_006887.4  

    Unigene Cluster for ZFP36L2:

    ZFP36 ring finger protein-like 2
    Hs.503093  [show with all ESTs]
    Unigene Representative Sequence: NM_006887
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000282388(uc002rsv.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZFP36L2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFP36L2 (see all 60):
    hsa-miR-128 hsa-miR-30d hsa-miR-371-5p hsa-miR-124 hsa-miR-30a hsa-miR-186 hsa-miR-506 hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidZFP36L2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ZFP36L2
    Predesigned siRNA for gene silencing in human, mouse, rat ZFP36L2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP36L2
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZFP36L2
      QuantiTect SYBR Green Assays in human, mouse, rat ZFP36L2
      QuantiFast Probe-based Assays in human, mouse, rat ZFP36L2

    Additional mRNA sequence: 

    BC005010.1 BC020369.1 X78992.1 

    22 DOTS entries:

    DT.91886932  DT.92459208  DT.95221570  DT.92459214  DT.92370510  DT.100807622  DT.100877206  DT.95108247 
    DT.120935730  DT.100877200  DT.100877205  DT.120935749  DT.75100380  DT.92459212  DT.95183890  DT.100684899 
    DT.120935737  DT.95118288  DT.95221571  DT.95250020  DT.97763135  DT.95287694 

    Selected AceView cDNA sequences (see all 223):

    AW136034 CD251448 AI302137 CA423901 H22216 CR614344 BI819830 AI972485 
    CK819088 BF062350 AI652878 BE645759 AW008142 CK819089 AI640912 BG390839 
    BU070641 NM_006887 CD671527 AA455965 AW070848 AA302841 BQ271279 AW205096 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFP36L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAAAGGCA
    ZFP36L2 Expression
    About this image


    ZFP36L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    ZFP36L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFP36L2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.503093
        Custom PCR Arrays for ZFP36L2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP36L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZFP36L2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp36l21 , 5 zinc finger protein 36, C3H type-like 21, 5 87.71(n)1
    89.37(a)1
      17 (55.02 cM)5
    121931  NM_001001806.21  NP_001001806.11 
     841839315 
    lizard
    (Anolis carolinensis)
    Reptilia ZFP36L26
    ZFP36 ring finger protein-like 2
    58(a)
    1 ↔ 1
    GL343231.1(1495538-1499017)
    African clawed frog
    (Xenopus laevis)
    Amphibia zfp36l2-prov2 zinc finger protein 36, C3H type-like 2 77.42(n)    BC044086.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zfp36l21 zinc finger protein 36, C3H type-like 2 64.86(n)
    68.78(a)
      333941  NM_207055.1  NP_996938.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tis113 DNA binding 81(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ccch-26
    Y60A9.36
    (see all 11)
    Protein Y60A9.3 (Y60A9.3) mRNA, complete cds
    (see all 11)
    27(a)
    26(a)
    (see all 11)
    many ↔ many
    many ↔ many
    (see all 11)
    IV(16278213-16279018) WBGene00009537
    X(14383251-14383862) WBGene00013370
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CTH1(YDR151C)4 Member of the CCCH zinc finger family; has similarity more   --   4(765155-764178) 851729  NP_010435.1 
    rice
    (Oryza sativa)
    Liliopsida AK068034.12   -- 73.02(n)    AK068034.1 


    ENSEMBL Gene Tree for ZFP36L2 (if available)
    TreeFam Gene Tree for ZFP36L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZFP36L2 gene
    ZFP36L12  ZFP362  

    ZFP36L2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFP36L2 (see all 114)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1150138551,2
    F--43449049(+) TTCTCC/TGACCC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1442568151,2
    --43449056(+) ACCCAC/GAAAAA 1 -- ds50010--------
    rs1838172281,2
    --43449113(+) GCCACC/TGGCTG 1 -- ds50010--------
    rs1880620421,2
    --43449114(+) CCACCA/GGCTGC 1 -- ds50010--------
    rs1477213271,2
    C--43449141(+) CCTTCC/TCCACC 1 -- ds50010--------
    rs1914533561,2
    --43449149(+) ACCCAA/GGCAGT 1 -- ds50010--------
    rs1836512571,2
    --43449156(+) CAGTTG/TTGTTT 1 -- ds50010--------
    rs1425006091,2
    C--43449187(+) TCAGCA/TGCTAC 1 -- ds50010--------
    rs1872410731,2
    --43449209(+) GATCCA/TCTCAG 1 -- ds50010--------
    rs1167011561,2
    F--43449214(+) ACTCAG/CTGACT 1 -- ds50011Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for ZFP36L2 (43449541 - 43453748 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZFP36L2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv25646CNV Loss19812545
    nsv829097CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFP36L2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612053    OMIM disorders: --

    UniProtKB/Swiss-Prot: TISD_HUMAN, P47974
  • Note=Defects in ZFP36L2 may be a cause of leukemias. Frameshfits mutations disrupting ZFP36L2 have been
    found in a patient with acute myeloid leukemia (PubMed:21109922)

  • 11 diseases for ZFP36L2:    
    About MalaCards
    folliculitis    papillary thyroid carcinoma    polycystic ovary syndrome    t-cell leukemia
    acute leukemia    hypoxia    renal cell carcinoma    thyroiditis
    leukemia    colorectal cancer    endotheliitis


    ZFP36L2 for disorders           About GeneDecksing


    Export disorders for ZFP36L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFP36L2 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with ZFP36L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. (PubMed id 14981510)1, 2, 3, 9 Hudson B.P.... Wright P.E. (Nat. Struct. Mol. Biol. 2004)
    2. Identification of a member of the TIS11 early response gene family at the insertion point of a DNA fragment containing a gene for the T-cell receptor beta chain in an acute T-cell leukemia. (PubMed id 8545129)1, 2, 3, 9 Ino T.... Kurosawa Y. (Oncogene 1995)
    3. ERF-2, the human homologue of the murine Tis11d early response gene. (PubMed id 7835719)1, 2, 3 Nie X.F.... Bustin S.A. (Gene 1995)
    4. Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia. (PubMed id 21109922)1, 2 Iwanaga E....Asou N. (Int. J. Oncol. 2011)
    5. A computational study of RNA binding and specificity in the tandem zinc finger domain of TIS11d. (PubMed id 20506496)1, 2 Morgan B.R. and Massi F. (Protein Sci. 2010)
    6. TIS11D is a candidate pro-apoptotic p53 target gene. (PubMed id 17172869)1, 3 Jackson R.S....Liang P. (Cell Cycle 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Polymorphisms in the genes encoding members of the tristetraprolin family of human tandem CCCH zinc finger proteins. (PubMed id 14604009)1, 9 Blackshear P.J....Mohrenweiser H. (Prog. Nucleic Acid Res. Mol. Biol. 2003)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. (PubMed id 21151128)1 Chen Z.J....Zhao Y. (Nat. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 678 HGNC: 1108 AceView: ZFP36L2 Ensembl:ENSG00000152518 euGenes: HUgn678
    ECgene: ZFP36L2 H-InvDB: ZFP36L2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZFP36L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZFP36L2 gene:
    Search GeneIP for patents involving ZFP36L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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