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Aliases for ZFP36L1 Gene

Aliases for ZFP36L1 Gene

  • ZFP36 Ring Finger Protein-Like 1 2 3
  • Zinc Finger Protein, C3H Type, 36-Like 1 2 3
  • Zinc Finger Protein 36, C3H Type-Like 1 2 3
  • Butyrate Response Factor 1 3 4
  • EGF-Response Factor 1 3 4
  • RNF162B 3 4
  • Berg36 3 4
  • TIS11B 3 4
  • ERF-1 3 4
  • ERF1 3 4
  • BRF1 3 4
  • Early Response Factor Berg36 3
  • Protein TIS11B 4
  • CMG1 3

External Ids for ZFP36L1 Gene

Previous HGNC Symbols for ZFP36L1 Gene

  • BRF1

Previous GeneCards Identifiers for ZFP36L1 Gene

  • GC14M066759
  • GC14M063048
  • GC14M067244
  • GC14M068324
  • GC14M069254
  • GC14M049422

Summaries for ZFP36L1 Gene

Entrez Gene Summary for ZFP36L1 Gene

  • This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for ZFP36L1 Gene

ZFP36L1 (ZFP36 Ring Finger Protein-Like 1) is a Protein Coding gene. Diseases associated with ZFP36L1 include sotos syndrome 1. Among its related pathways are ERK Signaling and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include poly(A) RNA binding and mRNA binding. An important paralog of this gene is ZFP36.

UniProtKB/Swiss-Prot for ZFP36L1 Gene

  • Probable regulatory protein involved in regulating the response to growth factors

Gene Wiki entry for ZFP36L1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP36L1 Gene

Genomics for ZFP36L1 Gene

Regulatory Elements for ZFP36L1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZFP36L1 Gene

Chromosome:
14
Start:
68,787,655 bp from pter
End:
68,796,253 bp from pter
Size:
8,599 bases
Orientation:
Minus strand

Genomic View for ZFP36L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFP36L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP36L1 Gene

Proteins for ZFP36L1 Gene

  • Protein details for ZFP36L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07352-TISB_HUMAN
    Recommended name:
    Zinc finger protein 36, C3H1 type-like 1
    Protein Accession:
    Q07352
    Secondary Accessions:
    • Q13851

    Protein attributes for ZFP36L1 Gene

    Size:
    338 amino acids
    Molecular mass:
    36314 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZFP36L1 Gene

neXtProt entry for ZFP36L1 Gene

Proteomics data for ZFP36L1 Gene at MOPED

Post-translational modifications for ZFP36L1 Gene

  • Ubiquitination at Lys 103
  • Modification sites at PhosphoSitePlus

Other Protein References for ZFP36L1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ZFP36L1 (BRF1)

No data available for DME Specific Peptides for ZFP36L1 Gene

Domains & Families for ZFP36L1 Gene

Gene Families for ZFP36L1 Gene

Protein Domains for ZFP36L1 Gene

Suggested Antigen Peptide Sequences for ZFP36L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q07352

UniProtKB/Swiss-Prot:

TISB_HUMAN :
  • Contains 2 C3H1-type zinc fingers.
Similarity:
  • Contains 2 C3H1-type zinc fingers.
genes like me logo Genes that share domains with ZFP36L1: view

Function for ZFP36L1 Gene

Molecular function for ZFP36L1 Gene

UniProtKB/Swiss-Prot Function:
Probable regulatory protein involved in regulating the response to growth factors

Gene Ontology (GO) - Molecular Function for ZFP36L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 8595910
GO:0003729 mRNA binding IDA 15467755
GO:0005515 protein binding IPI 16189514
GO:0017091 AU-rich element binding IEA --
genes like me logo Genes that share ontologies with ZFP36L1: view
genes like me logo Genes that share phenotypes with ZFP36L1: view

Animal Models for ZFP36L1 Gene

MGI Knock Outs for ZFP36L1:

Animal Model Products

CRISPR Products

miRNA for ZFP36L1 Gene

miRTarBase miRNAs that target ZFP36L1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFP36L1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ZFP36L1 Gene

Localization for ZFP36L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP36L1 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP36L1 Gene COMPARTMENTS Subcellular localization image for ZFP36L1 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for ZFP36L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ZFP36L1: view

Pathways & Interactions for ZFP36L1 Gene

genes like me logo Genes that share pathways with ZFP36L1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for ZFP36L1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ZFP36L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA --
GO:0001570 vasculogenesis IEA --
GO:0003342 proepicardium development IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 8595910
GO:0006402 mRNA catabolic process --
genes like me logo Genes that share ontologies with ZFP36L1: view

Drugs & Compounds for ZFP36L1 Gene

(1) Drugs for ZFP36L1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404

(2) Additional Compounds for ZFP36L1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-O-Tetradecanoylphorbol 13-acetate
butyrate
genes like me logo Genes that share compounds with ZFP36L1: view

Transcripts for ZFP36L1 Gene

Unigene Clusters for ZFP36L1 Gene

ZFP36 ring finger protein-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFP36L1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP36L1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for ZFP36L1 Gene

GeneLoc Exon Structure for
ZFP36L1
ECgene alternative splicing isoforms for
ZFP36L1

Expression for ZFP36L1 Gene

mRNA expression in normal human tissues for ZFP36L1 Gene

Protein differential expression in normal tissues from HIPED for ZFP36L1 Gene

This gene is overexpressed in Cervix (24.1), Lung (17.2), and Serum (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFP36L1 Gene



SOURCE GeneReport for Unigene cluster for ZFP36L1 Gene Hs.85155

genes like me logo Genes that share expression patterns with ZFP36L1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZFP36L1 Gene

Orthologs for ZFP36L1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZFP36L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZFP36L1 35
  • 95.76 (n)
  • 99.11 (a)
ZFP36L1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP36L1 35
  • 94.77 (n)
  • 98.22 (a)
ZFP36L1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp36l1 35
  • 93.59 (n)
  • 98.52 (a)
Zfp36l1 16
Zfp36l1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZFP36L1 35
  • 89.66 (n)
  • 87.08 (a)
ZFP36L1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp36l1 35
  • 94.38 (n)
  • 98.52 (a)
oppossum
(Monodelphis domestica)
Mammalia ZFP36L1 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFP36L1 35
  • 86.51 (n)
  • 91.57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16375 35
zfp36l1 35
  • 73.46 (n)
  • 80.86 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.475 35
zebrafish
(Danio rerio)
Actinopterygii wufc06f10 35
zfp36l1a 35
  • 69.55 (n)
  • 70.68 (a)
zfp36l1a 36
  • 57 (a)
OneToMany
zfp36l1b 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tis11 37
  • 72 (a)
Tis11 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C35D6.4 36
  • 27 (a)
ManyToMany
ccch-1 36
  • 20 (a)
ManyToMany
ccch-2 36
  • 26 (a)
ManyToMany
ccch-5 36
  • 24 (a)
ManyToMany
dct-13 36
  • 22 (a)
ManyToMany
F38C2.7 36
  • 24 (a)
ManyToMany
mex-1 36
  • 15 (a)
ManyToMany
pos-1 36
  • 22 (a)
ManyToMany
Y116A8C.19 36
  • 24 (a)
ManyToMany
Y116A8C.20 36
  • 23 (a)
ManyToMany
Y60A9.3 36
  • 23 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTH1 36
  • 18 (a)
ManyToMany
TIS11 36
  • 15 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.30567 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12113 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6084 36
  • 33 (a)
OneToMany
Species with no ortholog for ZFP36L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFP36L1 Gene

ENSEMBL:
Gene Tree for ZFP36L1 (if available)
TreeFam:
Gene Tree for ZFP36L1 (if available)

Paralogs for ZFP36L1 Gene

Paralogs for ZFP36L1 Gene

(2) SIMAP similar genes for ZFP36L1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZFP36L1: view

Variants for ZFP36L1 Gene

Sequence variations from dbSNP and Humsavar for ZFP36L1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs6739 -- 68,788,935(+) GGTGG(G/T)GGGGG intron-variant, utr-variant-3-prime
rs6740 -- 68,788,927(+) GGGGC(A/C)GGGGT intron-variant, utr-variant-3-prime
rs10443 -- 68,793,573(-) CTAAG(A/G)ACGGG utr-variant-5-prime, intron-variant
rs10656 -- 68,788,943(+) GGGTG(C/G/T)GGGGG intron-variant, utr-variant-3-prime
rs194778 -- 68,797,939(-) tggtt(A/T)catga upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZFP36L1 Gene

Variant ID Type Subtype PubMed ID
nsv902070 CNV Loss 21882294

Variation tolerance for ZFP36L1 Gene

Residual Variation Intolerance Score: 19.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP36L1 Gene

HapMap Linkage Disequilibrium report
ZFP36L1
Human Gene Mutation Database (HGMD)
ZFP36L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP36L1 Gene

Disorders for ZFP36L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFP36L1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sotos syndrome 1
  • sotos syndrome
- elite association

Relevant External Links for ZFP36L1

Genetic Association Database (GAD)
ZFP36L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP36L1
genes like me logo Genes that share disorders with ZFP36L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFP36L1 Gene

Publications for ZFP36L1 Gene

  1. Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes. (PMID: 8024689) Bustin S.A. … McKay L.A. (DNA Cell Biol. 1994) 2 23 67
  2. ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production. (PMID: 20166898) Hacker C. … Munz B. (Growth Factors 2010) 23 67
  3. Changes in protein tyrosine phosphatase type IVA member 1 and zinc finger protein 36 C3H type-like 1 expression demonstrate altered estrogen and progestin effect in medroxyprogesterone acetate-resistant and estrogen-independent breast cancer cell models. (PMID: 19146866) Pennanen P.T. … Ylikomi T.J. (Steroids 2009) 23 67
  4. Von Hippel-Lindau gene product modulates TIS11B expression in renal cell carcinoma: impact on vascular endothelial growth factor expression in hypoxia. (PMID: 19801654) Sinha S. … Mukhopadhyay D. (J. Biol. Chem. 2009) 23 67
  5. Production and characterization of ZFP36L1 antiserum against recombinant protein from Escherichia coli. (PMID: 18302406) Cao H. … Urban J.F. (Biotechnol. Prog. 2008) 23 67

Products for ZFP36L1 Gene

Sources for ZFP36L1 Gene

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