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Aliases for ZFP36L1 Gene

Aliases for ZFP36L1 Gene

  • ZFP36 Ring Finger Protein Like 1 2 3 5
  • Zinc Finger Protein, C3H Type, 36-Like 1 2 3
  • Zinc Finger Protein 36, C3H1 Type-Like 1 3 4
  • Zinc Finger Protein 36, C3H Type-Like 1 2 3
  • Butyrate Response Factor 1 3 4
  • TPA-Induced Sequence 11b 3 4
  • EGF-Response Factor 1 3 4
  • ZFP36-Like 1 3 4
  • RNF162B 3 4
  • Berg36 3 4
  • TIS11B 3 4
  • ERF-1 3 4
  • ERF1 3 4
  • BRF1 3 4
  • MRNA Decay Activator Protein ZFP36L1 3
  • Early Response Factor Berg36 3
  • CMG1 3

External Ids for ZFP36L1 Gene

Previous HGNC Symbols for ZFP36L1 Gene

  • BRF1

Previous GeneCards Identifiers for ZFP36L1 Gene

  • GC14M066759
  • GC14M063048
  • GC14M067244
  • GC14M068324
  • GC14M069254
  • GC14M049422

Summaries for ZFP36L1 Gene

Entrez Gene Summary for ZFP36L1 Gene

  • This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for ZFP36L1 Gene

ZFP36L1 (ZFP36 Ring Finger Protein Like 1) is a Protein Coding gene. Diseases associated with ZFP36L1 include Sotos Syndrome 1. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Validated targets of C-MYC transcriptional repression. GO annotations related to this gene include poly(A) RNA binding and mRNA binding. An important paralog of this gene is ZFP36L2.

UniProtKB/Swiss-Prot for ZFP36L1 Gene

  • Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3-end processing; modulates mRNA 3-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity).

Gene Wiki entry for ZFP36L1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP36L1 Gene

Genomics for ZFP36L1 Gene

Regulatory Elements for ZFP36L1 Gene

Enhancers for ZFP36L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F068818 1.3 FANTOM5 Ensembl ENCODE 12.8 -24.7 -24723 5.4 HDGF PKNOX1 WRNIP1 YY1 GLIS2 ZNF143 FOS SP3 REST SMARCA4 ZFP36L1 DCAF5 LOC105370548
GH14F068237 1.2 FANTOM5 Ensembl ENCODE 12.2 +550.7 550749 15.4 PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 YY1 ZNF766 ZNF143 FOS ZFP36L1 RN7SL108P GC14P068302
GH14F068732 1.4 FANTOM5 Ensembl ENCODE 10.8 +61.0 60952 5.0 HDGF TBP MAX TSC22D4 EBF1 ZNF2 ZNF48 RELA ZFHX2 GATA3 ZFP36L1 DCAF5 ENSG00000258623 GC14M068736 RNU6-921P GC14P068694
GH14F068931 1.6 FANTOM5 Ensembl ENCODE 8 -149.4 -149448 29.4 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ERH ACTN1 RPL7AP6 CCDC177 ZFP36L1 DCAF5 GALNT16 GC14P068937
GH14F068592 1.5 FANTOM5 Ensembl ENCODE 7.6 +199.2 199170 8.6 PKNOX1 ARID4B DMAP1 FOS JUNB PPARG TBX21 KAT8 PPARGC1A SSRP1 ZFP36L1 GC14P068562 ENSG00000258623
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZFP36L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZFP36L1 Gene

Chromosome:
14
Start:
68,787,655 bp from pter
End:
68,796,253 bp from pter
Size:
8,599 bases
Orientation:
Minus strand

Genomic View for ZFP36L1 Gene

Genes around ZFP36L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP36L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP36L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP36L1 Gene

Proteins for ZFP36L1 Gene

  • Protein details for ZFP36L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07352-TISB_HUMAN
    Recommended name:
    mRNA decay activator protein ZFP36L1
    Protein Accession:
    Q07352
    Secondary Accessions:
    • Q13851

    Protein attributes for ZFP36L1 Gene

    Size:
    338 amino acids
    Molecular mass:
    36314 Da
    Quaternary structure:
    • Associates with the cytoplasmic CCR4-NOT deadenylase and RNA exosome complexes to trigger ARE-containing mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Interacts with CNOT1 (PubMed:25106868). Interacts (via N-terminus) with CNOT6 (PubMed:15687258, PubMed:18326031). Interacts with CNOT7; this interaction is inhibited in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Interacts with DCP1A (PubMed:15687258). Interacts (via N-terminus) with DCP2 (PubMed:15687258, PubMed:18326031). Interacts (via N-terminus) with EXOSC2 (PubMed:15687258, PubMed:18326031). Interacts with XRN1 (PubMed:15687258). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (PubMed:15538381, PubMed:17030608, PubMed:18326031). Interacts (via phosphorylated form) with YWHAZ; this interaction occurs in a p38 MAPK- and AKT-signaling pathways (By similarity).

    Three dimensional structures from OCA and Proteopedia for ZFP36L1 Gene

neXtProt entry for ZFP36L1 Gene

Post-translational modifications for ZFP36L1 Gene

  • Phosphorylated (PubMed:19179481). Phosphorylated by RPS6KA1 at Ser-334 upon phorbol 12-myristate 13-acetate (PMA) treatment; this phosphorylation results in dissociation of the CCR4-NOT deadenylase complex and induces p38 MAPK-mediated stabilization of the low-density lipoprotein receptor LDLR mRNA (PubMed:25106868). Phosphorylated by protein kinase AKT1 at Ser-92 and Ser-203 in response to insulin; these phosphorylations stabilize ZFP36L1, increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization (PubMed:15538381, PubMed:17030608). AKT1-mediated phosphorylation at Ser-92 does not impair ARE-containing RNA-binding (PubMed:15538381). Phosphorylated at Ser-54, Ser-92 and Ser-203 by MAPKAPK2; these phosphorylations increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization in a protein kinase AKT1-independent manner (PubMed:18326031). MAPKAPK2-mediated phosphorylations at Ser-54, Ser-92 and Ser-203 do not impair ARE-containing RNA-binding (PubMed:18326031). Phosphorylations increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization during early adipogenesis in a p38 MAPK- and AKT-dependent manner (By similarity).
  • Ubiquitinated. Ubiquitination leads to proteasomal degradation, a process inhibited by phosphorylations at Ser-90, Ser-92 and Ser-203 (PubMed:17030608).
  • Ubiquitination at Lys 103
  • Modification sites at PhosphoSitePlus

Other Protein References for ZFP36L1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ZFP36L1 (BRF1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for ZFP36L1

No data available for DME Specific Peptides for ZFP36L1 Gene

Domains & Families for ZFP36L1 Gene

Gene Families for ZFP36L1 Gene

Protein Domains for ZFP36L1 Gene

Suggested Antigen Peptide Sequences for ZFP36L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q07352

UniProtKB/Swiss-Prot:

TISB_HUMAN :
  • Contains 2 C3H1-type zinc fingers.
Similarity:
  • Contains 2 C3H1-type zinc fingers.
genes like me logo Genes that share domains with ZFP36L1: view

Function for ZFP36L1 Gene

Molecular function for ZFP36L1 Gene

UniProtKB/Swiss-Prot Function:
Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3-end processing; modulates mRNA 3-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated under hypoxic conditions in endothelial cells (at protein level) (PubMed:21832157). Up-regulated by growth factor (TGF-beta), cytokines, tumor necrosis factor (TNF-alpha) and epidermal growth factor (EGF) in keratinocytes (PubMed:20166898). Up-regulated also by glucocorticoid dexamethasone in keratinocytes (PubMed:20166898). Up-regulated in keratinocytes in response to wounding in a p38 MAPK-dependent manner (PubMed:20166898, PubMed:27182009). Up-regulated by the parathyroid hormone (PTH) in osteoblast-like cells in a cAMP/PKA-dependent manner (PubMed:15465005, PubMed:19179481). Up-regulated in response to adrenocorticotropic hormone (ACTH) (PubMed:19179481). Up-regulated during monocyte/macrophage differentiation in response to phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (PubMed:26542173). Down-regulated by butyrate in colorectal cancer cells (PubMed:10367403).

Gene Ontology (GO) - Molecular Function for ZFP36L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 8595910
GO:0003729 mRNA binding IDA 15467755
GO:0003730 mRNA 3-UTR binding IBA --
GO:0005515 protein binding IPI 15687258
genes like me logo Genes that share ontologies with ZFP36L1: view
genes like me logo Genes that share phenotypes with ZFP36L1: view

Animal Models for ZFP36L1 Gene

MGI Knock Outs for ZFP36L1:

Animal Model Products

miRNA for ZFP36L1 Gene

miRTarBase miRNAs that target ZFP36L1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZFP36L1 Gene

Localization for ZFP36L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP36L1 Gene

Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, P-body. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner (By similarity). Component of cytoplasmic stress granules (PubMed:15967811). Localizes in processing bodies (PBs) (PubMed:17369404). {ECO:0000250 UniProtKB:P23950, ECO:0000269 PubMed:15967811, ECO:0000269 PubMed:17369404}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP36L1 Gene COMPARTMENTS Subcellular localization image for ZFP36L1 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for ZFP36L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 17369404
GO:0005634 nucleus IEA,IDA 12198173
GO:0005737 cytoplasm IEA,IDA 12198173
GO:0005829 cytosol TAS --
GO:0030529 intracellular ribonucleoprotein complex IDA 15687258
genes like me logo Genes that share ontologies with ZFP36L1: view

Pathways & Interactions for ZFP36L1 Gene

genes like me logo Genes that share pathways with ZFP36L1: view

Pathways by source for ZFP36L1 Gene

SIGNOR curated interactions for ZFP36L1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ZFP36L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IDA 18326031
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA --
GO:0001570 vasculogenesis IEA --
GO:0003342 proepicardium development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZFP36L1: view

Drugs & Compounds for ZFP36L1 Gene

(1) Drugs for ZFP36L1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for ZFP36L1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZFP36L1: view

Transcripts for ZFP36L1 Gene

Unigene Clusters for ZFP36L1 Gene

ZFP36 ring finger protein-like 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP36L1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for ZFP36L1 Gene

GeneLoc Exon Structure for
ZFP36L1
ECgene alternative splicing isoforms for
ZFP36L1

Expression for ZFP36L1 Gene

mRNA expression in normal human tissues for ZFP36L1 Gene

Protein differential expression in normal tissues from HIPED for ZFP36L1 Gene

This gene is overexpressed in Cervix (24.1), Lung (17.2), and Serum (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFP36L1 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZFP36L1 Gene:

ZFP36L1

SOURCE GeneReport for Unigene cluster for ZFP36L1 Gene:

Hs.85155

mRNA Expression by UniProt/SwissProt for ZFP36L1 Gene:

Q07352-TISB_HUMAN
Tissue specificity: Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009). Expressed in osteoblasts (PubMed:15465005).
genes like me logo Genes that share expression patterns with ZFP36L1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZFP36L1 Gene

Orthologs for ZFP36L1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZFP36L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZFP36L1 34 35
  • 95.76 (n)
dog
(Canis familiaris)
Mammalia ZFP36L1 34 35
  • 94.77 (n)
rat
(Rattus norvegicus)
Mammalia Zfp36l1 34
  • 94.38 (n)
mouse
(Mus musculus)
Mammalia Zfp36l1 34 16 35
  • 93.59 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFP36L1 35
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZFP36L1 34 35
  • 89.66 (n)
chicken
(Gallus gallus)
Aves ZFP36L1 34
  • 86.51 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia zfp36l1 34
  • 73.46 (n)
Str.16375 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.475 34
zebrafish
(Danio rerio)
Actinopterygii zfp36l1a 34 35
  • 69.55 (n)
zfp36l1b 35
  • 56 (a)
OneToMany
wufc06f10 34
fruit fly
(Drosophila melanogaster)
Insecta Tis11 36 35
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea C35D6.4 35
  • 27 (a)
ManyToMany
ccch-2 35
  • 26 (a)
ManyToMany
ccch-5 35
  • 24 (a)
ManyToMany
F38C2.7 35
  • 24 (a)
ManyToMany
Y116A8C.19 35
  • 24 (a)
ManyToMany
Y116A8C.20 35
  • 23 (a)
ManyToMany
Y60A9.3 35
  • 23 (a)
ManyToMany
dct-13 35
  • 22 (a)
ManyToMany
pos-1 35
  • 22 (a)
ManyToMany
ccch-1 35
  • 20 (a)
ManyToMany
mex-1 35
  • 15 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTH1 35
  • 18 (a)
ManyToMany
TIS11 35
  • 15 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.30567 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6084 35
  • 33 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12113 34
Species where no ortholog for ZFP36L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFP36L1 Gene

ENSEMBL:
Gene Tree for ZFP36L1 (if available)
TreeFam:
Gene Tree for ZFP36L1 (if available)

Paralogs for ZFP36L1 Gene

Paralogs for ZFP36L1 Gene

(2) SIMAP similar genes for ZFP36L1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZFP36L1: view

Variants for ZFP36L1 Gene

Sequence variations from dbSNP and Humsavar for ZFP36L1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10443 -- 68,793,573(-) CTAAG(A/G)ACGGG intron-variant, utr-variant-5-prime
rs1051371 -- 68,787,944(-) AAGGG(A/C/G)AAAAA utr-variant-3-prime
rs1051533 -- 68,792,945(-) CGAAC(G/T)CACAG reference, synonymous-codon, utr-variant-5-prime
rs10656 -- 68,788,943(+) GGGTG(C/G)GGGGG intron-variant, utr-variant-3-prime
rs11158764 -- 68,787,538(+) ATGCC(G/T)CCACC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZFP36L1 Gene

Variant ID Type Subtype PubMed ID
dgv1097n106 CNV deletion 24896259
nsv1070226 CNV deletion 25765185
nsv1116460 OTHER inversion 24896259
nsv952859 CNV deletion 24416366

Variation tolerance for ZFP36L1 Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP36L1 Gene

Human Gene Mutation Database (HGMD)
ZFP36L1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP36L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP36L1 Gene

Disorders for ZFP36L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFP36L1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sotos syndrome 1
  • sotos syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZFP36L1

Genetic Association Database (GAD)
ZFP36L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP36L1
genes like me logo Genes that share disorders with ZFP36L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFP36L1 Gene

Publications for ZFP36L1 Gene

  1. Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes. (PMID: 8024689) Bustin S.A. … McKay L.A. (DNA Cell Biol. 1994) 2 3 4 22 64
  2. ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production. (PMID: 20166898) Hacker C. … Munz B. (Growth Factors 2010) 3 4 22 64
  3. Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells. (PMID: 15465005) Reppe S. … Jemtland R. (Biochem. Biophys. Res. Commun. 2004) 3 4 22 64
  4. Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b. (PMID: 15467755) Ciais D. … Feige J.J. (Oncogene 2004) 3 4 22 64
  5. Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. (PMID: 12198173) Stoecklin G. … Moroni C. (EMBO J. 2002) 3 4 22 64

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