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ZFP36L1 Gene

protein-coding   GIFtS: 63
GCID: GC14M069254

ZFP36 Ring Finger Protein-Like 1

(Previous names: zinc finger protein, C3H type, 36-like 1, zinc finger protein...)
(Previous symbol: BRF1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ZFP36 Ring Finger Protein-Like 11 2     TIS11B2 3
BRF11 2 3 5     EGF-Response Factor 12 3
ERF12 3 5     Berg362
Zinc Finger Protein 36, C3H Type-Like 11 2     cMG12
Zinc Finger Protein, C3H Type, 36-Like 11 2     Early Response Factor Berg362
Butyrate Response Factor 12 3     Zinc Finger Protein 36, C3H1 Type-Like 12
ERF-12 3     BERG363
RNF162B2 3     Protein TIS11B3

External Ids:    HGNC: 11071   Entrez Gene: 6772   Ensembl: ENSG000001856507   OMIM: 6010645   UniProtKB: Q073523   

Export aliases for ZFP36L1 gene to outside databases

Previous GC identifers: GC14M066759 GC14M063048 GC14M067244 GC14M068324 GC14M049422


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZFP36L1 Gene:
This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as
the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a
promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing
putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most
likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for ZFP36L1 Gene:
ZFP36L1 (ZFP36 ring finger protein-like 1) is a protein-coding gene. GO annotations related to this gene include mRNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZFP36L2.

UniProtKB/Swiss-Prot: TISB_HUMAN, Q07352
Function: Probable regulatory protein involved in regulating the response to growth factors

Gene Wiki entry for ZFP36L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFP36L1 gene promoter:
         Egr-3   AREB6   c-Fos   AP-1   COMP1   ATF-2   c-Jun   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFP36L1 promoter sequence
   Search Chromatin IP Primers for ZFP36L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFP36L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22-q24   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q22-q24

ZFP36L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP36L1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M069254:  view genomic region     (about GC identifiers)

Start:
69,254,375 bp from pter      End:
69,263,190 bp from pter
Size:
8,816 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TISB_HUMAN, Q07352 (See protein sequence)
Recommended Name: Zinc finger protein 36, C3H1 type-like 1  
Size: 338 amino acids; 36314 Da
2 PDB 3D structures from and Proteopedia for ZFP36L1:
1W0V (3D)        1W0W (3D)    
Secondary accessions: Q13851

Explore the universe of human proteins at neXtProt for ZFP36L1: NX_Q07352

Explore proteomics data for ZFP36L1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys103
  • Modification sites at PhosphoSitePlus

  • See ZFP36L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001231627.1  NP_001231630.1  NP_004917.2  

    ENSEMBL proteins: 
     ENSP00000451093   ENSP00000388402   ENSP00000337386   ENSP00000450784   ENSP00000450600  
     ENSP00000452119   ENSP00000386220  
    Reactome Protein details: Q07352

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR007635 Tis11B_N

    Graphical View of Domain Structure for InterPro Entry Q07352

    ProtoNet protein and cluster: Q07352

    2 Blocks protein domains:
    IPB000571 Zn-finger
    IPB007635 Tis11B like protein


    UniProtKB/Swiss-Prot: TISB_HUMAN, Q07352
    Similarity: Contains 2 C3H1-type zinc fingers


    Find genes that share domains with ZFP36L1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TISB_HUMAN, Q07352
    Function: Probable regulatory protein involved in regulating the response to growth factors

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS8595910
    GO:0003729mRNA binding IDA15467755
    GO:0005515protein binding IPI16189514
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with ZFP36L1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZFP36L1:
     Increased cell death HMECs cel  Increased cell death in breast 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Zfp36l1):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     immune system  mortality/aging  muscle  nervous system  tumorigenesis 

    Find genes that share phenotypes with ZFP36L1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ZFP36L1: Zfp36l1tm1Seb Zfp36l1tm1Pjb

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    miRTarBase miRNAs that target ZFP36L1:
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    Selected qRT-PCR Assays for microRNAs that regulate ZFP36L1 (see all 68):
    hsa-miR-100* hsa-miR-3607-3p hsa-miR-128 hsa-miR-3161 hsa-miR-629 hsa-miR-3613-3p hsa-miR-3148 hsa-miR-27a
    SwitchGear 3'UTR luciferase reporter plasmidZFP36L1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TISB_HUMAN, Q07352: Cytoplasm (By similarity). Nucleus (By similarity). Note=Shuttles between the nucleus and
    the cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ZFP36L1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZFP36L1 About    
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62
    Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)0.00
    2Gene Expression
    Gene Expression0.40
    3Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression
    4Translational Control
    Translational Control
    5PI3K / Akt Signaling
    PI3K / Akt Signaling


    Find genes that share SuperPaths with ZFP36L1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ZFP36L1
        ERK Signaling
    Transcription of tRNA
    Assembly of RNA Polymerase-III Initiation Complex

    2 Cell Signaling Technology (CST) Pathways for ZFP36L1
        Translational Control
    PI3K / Akt Signaling

    1 BioSystems Pathway for ZFP36L1
        Validated targets of C-MYC transcriptional repression

    1 Reactome Pathway for ZFP36L1
        Butyrate Response Factor 1 (BRF1) destabilizes mRNA


        Pathway & Disease-focused RT2 Profiler PCR Array including ZFP36L1: 
              Osmotic Stress in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ZFP36L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZFP36L1 (Q073521, 2, 3 ENSP000003373864) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAFAH1B2P684022, 3MINT-64001 I2D: score=4 
    MAPK14Q165391, 2, 3, ENSP000002297944EBI-721823,EBI-73946 MINT-66629 I2D: score=6 STRING: ENSP00000229794
    YWHAZP631042, 3, ENSP000003095034MINT-8006780 I2D: score=2 STRING: ENSP00000309503
    PCBD1P614573, ENSP000002992994I2D: score=1 STRING: ENSP00000299299
    AKT1P317493, ENSP000002702024I2D: score=1 STRING: ENSP00000270202
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA--
    GO:0001570vasculogenesis IEA--
    GO:0006355regulation of transcription, DNA-templated NAS8595910
    GO:0006417regulation of translation IEA--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with ZFP36L1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFP36L1 (TISB)

    3 Novoseek inferred chemical compound relationships for ZFP36L1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    butyrate 72.2 14 15465005 (2), 15880358 (2), 14505090 (2), 12198173 (1) (see all 8)
    zinc 53.3 4 12198173 (1), 15465005 (1), 19146866 (1)
    12-o-tetradecanoylphorbol 13-acetate 50.8 1 1996120 (1)



    Find genes that share compounds with ZFP36L1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZFP36L1 gene (3 alternative transcripts): 
    NM_001244698.1  NM_001244701.1  NM_004926.3  

    Unigene Cluster for ZFP36L1:

    ZFP36 ring finger protein-like 1
    Hs.85155  [show with all ESTs]
    Unigene Representative Sequence: NM_004926
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555997 ENST00000439696(uc001xki.2 uc001xkh.2 uc021rve.1)
    ENST00000336440 ENST00000557086 ENST00000557022 ENST00000553375 ENST00000408913(uc021rvf.1)

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    hsa-miR-100* hsa-miR-3607-3p hsa-miR-128 hsa-miR-3161 hsa-miR-629 hsa-miR-3613-3p hsa-miR-3148 hsa-miR-27a
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    Additional mRNA sequence: 

    AK024202.1 AK294363.1 AK303917.1 BC018340.1 BT019468.1 X99404.1 

    21 DOTS entries:

    DT.97815486  DT.100850749  DT.97857953  DT.40254588  DT.92039757  DT.100850748  DT.421886  DT.100850745 
    DT.100850747  DT.91718890  DT.97763276  DT.120731716  DT.120731681  DT.120731706  DT.95163528  DT.120731702 
    DT.87016293  DT.95163527  DT.100850742  DT.100850746  DT.99976541 

    Selected AceView cDNA sequences (see all 642):

    BM708149 BQ084344 AW243771 BM730098 AA953836 AA653335 BX327372 AI568121 
    AV660625 AW769349 AA634410 AA283920 AI623425 AL120202 BM711392 BQ723425 
    BF339451 BQ921197 CR592455 CD674674 BM978865 AI085259 AW515168 BE047218 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZFP36L1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
    SP1:                    -                       -     -         
    SP2:                    -                                       
    SP3:                    -                                       
    SP4:                                                            


    ECgene alternative splicing isoforms for ZFP36L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFP36L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGGGTGGA
    ZFP36L1 Expression
    About this image


    ZFP36L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Medulla Oblongata
             Midbrain dopaminergic-like neurons
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
    ZFP36L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFP36L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.85155
        Pathway & Disease-focused RT2 Profiler PCR Array including ZFP36L1: 
              Osmotic Stress in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP36L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZFP36L1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp36l11 , 5 zinc finger protein 36, C3H type-like 11, 5 93.59(n)1
    98.52(a)1
      12 (36.46 cM)5
    121921  NM_007564.51  NP_031590.11 
     801077605 
    chicken
    (Gallus gallus)
    Aves ZFP36L11 ZFP36 ring finger protein-like 1 86.51(n)
    91.57(a)
      101751828  XM_004951104.1  XP_004951161.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.4752 Xenopus laevis CCCH zinc finger protein C3H-2 (C3H-2) more 81.84(n)    AF061981.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc06f102 wufc06f10 77.09(n)   323671  BC063991.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tis113 DNA binding 72(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C35D6.46
    ccch-26
    (see all 11)
    Protein CCCH-2 (ccch-2) mRNA, complete cds
    (see all 11)
    27(a)
    26(a)
    (see all 11)
    many ↔ many
    many ↔ many
    (see all 11)
    IV(16350990-16351601) WBGene00007961
    IV(16278213-16279018) WBGene00009537
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CTH16
    TIS116
    Member of the CCCH zinc finger family; has similar...
    mRNA-binding protein expressed during iron starvat...
    18(a)
    15(a)
    many ↔ many
    many ↔ many
    IV(764178-765155) YDR151C
    XII(415801-416658) YLR136C
    rice
    (Oryza sativa)
    Liliopsida Os.305672 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.99(n)    AK108658.1 


    ENSEMBL Gene Tree for ZFP36L1 (if available)
    TreeFam Gene Tree for ZFP36L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZFP36L1 gene
    ZFP36L22  ZFP362  
    2 SIMAP similar genes for ZFP36L1 using alignment to 6 protein entries:     TISB_HUMAN (see all proteins):
    MKRN1    ZFP36

    Find genes that share paralogs with ZFP36L1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFP36L1 (see all 240)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs48992571,2
    C,F,A,H--69253984(+) CCAAAT/GGAATG 3 -- ds500111Minor allele frequency- G:0.42EA NS WA NA CSA 544
    rs801922961,2
    C,F--69254071(+) GTGTCG/AGCAAG 3 -- ds50012Minor allele frequency- A:0.05CSA NA 121
    rs49026471,2
    C,F,A,H--69254191(+) CTAAGC/TGCAGC 3 -- ds500125Minor allele frequency- T:0.47NS EA WA NA CSA 2772
    rs1826544361,2
    --69254238(+) GCTTAC/TAGGGA 3 -- ds50010--------
    rs111587641,2
    C,F,A,H--69254255(+) ATGCCG/TCCACC 3 -- ds500119Minor allele frequency- T:0.19NS EA NA WA 2340
    rs71464911,2
    C,F,H--69254294(+) CCCCTC/ACCCAG 3 -- ds500112Minor allele frequency- A:0.26NA WA CSA EA 378
    rs558158861,2
    C,F--69254299(+) ACCCAG/AGACTT 3 -- ds50012Minor allele frequency- A:0.07NA 122
    rs1881218481,2
    --69254311(+) CAAGGC/TATACA 3 -- ds50010--------
    rs1468262211,2
    --69254341(+) AAAGTC/TAAACC 3 -- ds50010--------
    rs609972321,2
    C--69254436(+) AAAAG-/TTTTTT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ZFP36L1 (69254375 - 69263190 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZFP36L1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv902070CNV Loss21882294

    Human Gene Mutation Database (HGMD): ZFP36L1
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ZFP36L1
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFP36L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601064    OMIM disorders: --


    Find genes that share disorders with ZFP36L1           About GenesLikeMe

    Genetic Association Database (GAD): ZFP36L1

    Export disorders for ZFP36L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFP36L1 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with ZFP36L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes. (PubMed id 8024689)1, 2, 3, 9 Bustin S.A.... McKay L.A. (DNA Cell Biol. 1994)
    2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (Nature 2011)
    3. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36. (PubMed id 8898945)1, 2 Ning Z.Q.... Murphy J.J. (Eur. J. Immunol. 1996)
    6. Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes. (PubMed id 8346037)1, 2 Barnard R.C....Bustin S.A. (Nucleic Acids Res. 1993)
    7. Von Hippel-Lindau gene product modulates TIS11B expression in renal cell carcinoma: impact on vascular endothelial growth factor expression in hypoxia. (PubMed id 19801654)1, 9 Sinha S....Mukhopadhyay D. (J. Biol. Chem. 2009)
    8. Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells. (PubMed id 15465005)1, 9 Reppe S....Jemtland R. (Biochem. Biophys. Res. Commun. 2004)
    9. ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production. (PubMed id 20166898)1, 9 Hacker C....Munz B. (Growth Factors 2010)
    10. Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b. (PubMed id 15467755)1, 9 Ciais D....Feige J.J. (Oncogene 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 677 HGNC: 1107 AceView: ZFP36L1andFLJ39779 Ensembl:ENSG00000185650 euGenes: HUgn677
    ECgene: ZFP36L1 H-InvDB: ZFP36L1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZFP36L1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZFP36L1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFP36L1 gene:
    Search GeneIP for patents involving ZFP36L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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