Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFP36 Gene

protein-coding   GIFtS: 57
GCID: GC19P039897

ZFP36 ring finger protein

(Previous names: zinc finger protein 36, C3H type, homolog (mouse) )
 Explore 19 diseases affiliated with
ZFP36 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZFP36    

Aliases
for ZFP36 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ZFP36 Ring Finger Protein1 2     Zinc Finger Protein 36, C3H Type, Homolog (Mouse)1
TTP1 2 3 5     GOS242
G0S241 2 3     Tristetraproline1
RNF162A1 2 3     Zfp-363
TIS111 2 3     Zinc Finger Protein 36, C3H Type, Homolog2
NUP4751 2     Zinc Finger Protein, C3H Type, 36 Homolog2
Tristetraprolin1     TIS11A3
Growth Factor-Inducible Nuclear Protein NUP4752 3     Zfp-363
Zinc Finger Protein 36 Homolog2 3     Protein TIS11A3
G0/G1 Switch Regulatory Protein 242 3     

External Ids:    HGNC: 128621   Entrez Gene: 75382   Ensembl: ENSG000001280167   OMIM: 1907005   UniProtKB: P266513   

Export aliases for ZFP36 gene to outside databases

Previous GC identifers: GC19P040538 GC19P040288 GC19P044573 GC19P044589 GC19P036344


Summaries
for ZFP36 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TTP_HUMAN, P26651
Function: mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs.
Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Plays a key role in the
post-transcriptional regulation of tumor necrosis factor (TNF)

Gene Wiki entry for ZFP36


Genomic Views
for ZFP36 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFP36 gene promoter:
         c-Fos   Sp1   AP-1   p300   ATF-2   c-Jun   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZFP36 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFP36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

ZFP36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP36 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P039897:  view genomic region     (about GC identifiers)

Start:
 39,897,487 bp from pter      End:
 39,900,045 bp from pter
Size:
 2,559 bases      Orientation:
 plus strand

Proteins
for ZFP36 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TTP_HUMAN, P26651 (See protein sequence)
Recommended Name: Tristetraprolin  
Size: 326 amino acids; 34003 Da
Subcellular location: Nucleus. Cytoplasm. Note=Localizes to stress granules upon energy starvation. phosphorylation by
MAPKAPK2 promotes exclusion from stress granules
Secondary accessions: B2RA54

Explore the universe of human proteins at neXtProt for ZFP36: NX_P26651

Post-translational modifications:

  • Phosphorylation by MAPKAPK2 increases its stability and binding to 14-3-3 proteins, leading to reduce its ARE affinity
    • leading to inhibition of degradation of ARE-containing transcripts. Phosphorylated upon mitogen stimulation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P26651

    • ZFP36 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003398.2  
    ENSEMBL proteins: 
     ENSP00000248673  
    Reactome Protein details: P26651
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ZFP36
    OriGene Custom Protein Services for ZFP36 
    GenScript Custom Purified and Recombinant Proteins Services for ZFP36
    Novus Biologicals ZFP36 Protein
    Novus Biologicals ZFP36 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZFP36

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10330172
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0010494cytoplasmic stress granule IDA15014438


    ZFP36 for ontologies           About GeneDecksing



    ZFP36 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ZFP36
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 12): ZFP36
    OriGene Custom Antibody Services for ZFP36 
    GenScript Custom Superior Antibodies Services for ZFP36
    Novus Biologicals ZFP36 Antibodies
    Search for Antibodies for ZFP36 at Abcam  
    Uscn Antibodies for ZFP36
    Search ThermoFisher Antibodies for ZFP36

    Assay Products for ZFP36: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZFP36
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ZFP36

    Protein Domains /
    Families
    for ZFP36 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZFP36 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000571 Znf_CCCH

    Graphical View of Domain Structure for InterPro Entry P26651

    ProtoNet protein and cluster: P26651

    1 Blocks protein family: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: TTP_HUMAN, P26651
    Similarity: Contains 2 C3H1-type zinc fingers


    Function
    for ZFP36 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TTP_HUMAN, P26651
    Function: mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs.
    Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Plays a key role in the
    post-transcriptional regulation of tumor necrosis factor (TNF)
    Induction: By stimulation with various mitogens

         Genatlas biochemistry entry for ZFP36:
    zinc finger protein,proline rich,insulin and growth factor inducible,homologous to mouse tristetraprolin (ZFp-36)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ZFP36
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFP36
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFP36 (see all 26):
    hsa-miR-142-5p hsa-miR-520d-5p hsa-miR-551a hsa-miR-513a-5p hsa-miR-29c hsa-miR-29a hsa-miR-548v hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmid: ZFP36 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFP36 (see all 7)
    OriGene shRNA RFP: ZFP36
    OriGene siRNA: ZFP36
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFP36

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ZFP36

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP36 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP36 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ZFP36 (NM_004926)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFP36
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP36 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ZFP36
    Search LifeMap BioReagents cell lines for ZFP36

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ZFP36

    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003727single-stranded RNA binding TAS9703499
    GO:0003729mRNA binding IDA11782475
    GO:0005515protein binding IPI16364915
    GO:0008270zinc ion binding IEA--


    ZFP36 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for ZFP36:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
         Mouse knock-out Zfp36tm1Pjb for ZFP36
         15 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Zfp36):
     adipose tissue  behavior/neurological  cardiovascular system  digestive/alimentary  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  renal/urinary system  respiratory system  skeleton  vision/eye 

    ZFP36 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ZFP36 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    2Destabilization of mRNA by Tristetraprolin (TTP)
    		Destabilization of mRNA by Tristetraprolin (TTP)1.00
    3ErbB1 downstream signaling
    		ErbB1 downstream signaling1.00
    4Ubiquitinated Orc1 is degraded by the proteasome
    		Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.55
    5Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for ZFP36 
        ErbB1 downstream signaling

    5        Reactome Pathways for ZFP36
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    Destabilization of mRNA by Tristetraprolin (TTP)
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression



    ZFP36 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFP36

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/43 Interacting proteins for ZFP36 (P266511, 2, 3 ENSP000002486734) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-67159 I2D: score=5 STRING: ENSP00000311695
    DCP1AQ9NPI61, 3EBI-374248,EBI-374238 I2D: score=1 
    EDC3Q96F861, 3, ENSP000003205034EBI-374248,EBI-997311 I2D: score=2 STRING: ENSP00000320503
    UPF2Q9HAU53, ENSP000003487084I2D: score=3 STRING: ENSP00000348708
    EXOSC6Q5RKV63, ENSP000003985974I2D: score=2 STRING: ENSP00000398597
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ----
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening IEA--
    GO:0006402mRNA catabolic process IDA11782475
    GO:0006950response to stress IDA15014438


    ZFP36 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZFP36 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZFP36 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFP36
    10/13 Novoseek chemical compound relationships for ZFP36 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 66.1 87 20052970 (5), 17105199 (3), 15117938 (3), 10072766 (2) (see all 32)
    actinomycin d 37 5 19925787 (2), 16982682 (1), 18523301 (1)
    adenine 36 4 19435930 (1), 17599736 (1), 1627834 (1)
    cycloheximide 29.2 3 16982682 (1), 9539105 (1), 17369404 (1)
    infliximab 27 2 17599736 (2)
    butyrate 24.9 6 10367403 (3), 12198173 (1), 16982678 (1)
    adenylate 22.2 9 12748283 (3), 17855506 (1), 17964608 (1), 15117938 (1) (see all 5)
    mifepristone 19.3 1 16982682 (1)
    arsenite 18.6 2 15944294 (1), 16982678 (1)
    12-o-tetradecanoylphorbol 13-acetate 13.1 3 1996120 (2), 7615073 (1)

    Search CenterWatch for drugs/clinical trials and news about ZFP36 / TTP 

    Transcripts
    for ZFP36 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZFP36 gene: 
    NM_003407.3  

    Unigene Cluster for ZFP36:

    ZFP36 ring finger protein
    Hs.534052  [show with all ESTs]
    Unigene Representative Sequence: NM_003407
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000248673(uc002olh.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ZFP36
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFP36
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFP36 (see all 26):
    hsa-miR-142-5p hsa-miR-520d-5p hsa-miR-551a hsa-miR-513a-5p hsa-miR-29c hsa-miR-29a hsa-miR-548v hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmid: ZFP36 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFP36 (see all 7)
    OriGene shRNA RFP: ZFP36
    OriGene siRNA: ZFP36
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFP36
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP36 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP36 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ZFP36 (NM_004926)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFP36
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP36 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFP36
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFP36
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFP36
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP36

    Additional cDNA sequence: 

    AK314042.1 BC009693.1 M63625.1 M92843.1 

    24/34 DOTS entries (see all 34):

    DT.95370479  DT.100692470  DT.121415663  DT.100846146  DT.452147  DT.92451941  DT.100684836  DT.100846149 
    DT.100846168  DT.40255181  DT.100846153  DT.100760728  DT.121415753  DT.121415642  DT.40261034  DT.121415831 
    DT.121415870  DT.95205743  DT.95221092  DT.99943256  DT.100838912  DT.100846157  DT.100846160  DT.121415631 

    24/595 AceView cDNA sequences (see all 595):

    AA459283 BM023232 BQ003681 BU151092 H21714 CB162225 CR615152 CR609570 
    CR626058 CR618597 CR597638 AA459512 CR615025 AI754035 AI306504 CR604736 
    BQ893650 CR617754 AA436365 AL551985 BI962605 AL046873 BI793300 BE465739 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZFP36    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for ZFP36

    Expression
    for ZFP36 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFP36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGTGGGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZFP36 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Umbilical CordUmbilical VeinsUmbilical Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Secondary follicles (Primary Cell)Ovary, Reproductive System

    See ZFP36 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFP36

    SOURCE GeneReport for Unigene cluster: Hs.534052
        SABiosciences Custom PCR Arrays for ZFP36
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFP36
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFP36
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFP36
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP36
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ZFP36

    Orthologs
    for ZFP36 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZFP36 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zfp361 , 5 zinc finger protein 361, 5 84.7(n)1
    86.16(a)1    		   7 (16.72 cM)5
    226951  NM_011756.41  NP_035886.11 
     283767845 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1141301 zgc:114130 51.98(n)
    47.89(a)    		   570332  NM_001030247.1  NP_001025418.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y60A9.36
    ccch-26
    (see all 16)    		 Protein Y60A9.3
    CCCH-type zinc finger transcription factor family ...
    (see all 16)    		 20(a)
    20(a)
    (see all 16)    		 possible ortholog
    possible ortholog
    (see all 16)    		 X(14383181-14383792)
    IV(16278181-16278986)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G668106
    AT1G682006
    		 zinc finger CCCH domain-containing protein 15
    		 15(a)
    15(a)
    		 many ↔ many
    many ↔ many
    		 1(24927613-24928803)
    1(25562118-25563948)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 zinc finger C-x8-C-x5-C-x3-H type family protein
    zinc finger C-x8-C-x5-C-x3-H type family protein, ...
    (see all 3)    		 13(a)
    11(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 1(25959059-25960151)
    5(28639588-28641862)


    ENSEMBL Gene Tree for ZFP36 (if available)
    TreeFam Gene Tree for ZFP36 (if available) 

    Paralogs
    for ZFP36 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFP36 gene
    ZFP36L12  ZFP36L22  

    ZFP36 for paralogs           About GeneDecksing



    Genomic Variants
    for ZFP36 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/83 NCBI SNPs in ZFP36 are shown (see all 83)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1384247051,2
    		--39895518(+) GAATGC/TGTGAA 1 -- us2k10--------
    rs5655451,2
    		C,A,H,--39895580(+) CTGGGC/TGAAAG 1 -- us2k13Minor allele frequency- T:0.00NA WA CSA 5
    rs356951181,2
    		C--39895680(+) TGACC-/TTTTTT 1 -- us2k11Minor allele frequency- T:0.00CSA 2
    rs178822701,2
    		C,--39895873(+) GTCTCG/ACTCTG 1 -- us2k12Minor allele frequency- A:0.01NS WA 292
    rs178846821,2
    		C,--39896136(+) GGTGTG/AAGCCG 1 -- us2k11Minor allele frequency- A:0.01NS 170
    rs178799481,2
    		C,F,--39896140(+) TGAGCC/TGGGCA 1 -- us2k12Minor allele frequency- T:0.01NS WA 288
    rs178796691,2
    		C,F,--39896430(+) CTTATC/GTGTCT 1 -- us2k11Minor allele frequency- G:0.01NS 178
    rs1877963681,2
    		--39896619(+) TTTTTC/GTAGAC 1 -- us2k10--------
    rs711695911,2
    		C--39896828(+) CTTTC-/AAAAAAA 1 -- us2k11Minor allele frequency- AA:0.00NA 2
    rs1903197081,2
    		--39896840(+) AAAAAA/GAAGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZFP36 (39897487 - 39900045 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZFP36: --
    Human Gene Mutation Database (HGMD): ZFP36

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFP36
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFP36

    Disorders / Diseases
    for ZFP36 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZFP36 for disorders           About GeneDecksing

    OMIM gene information: 190700    OMIM disorders: --

    19 diseases for ZFP36:    About MalaCards
    rheumatoid arthritis    herpes simplex    insulin resistance    malignant glioma
    cervical cancer    arthritis    osteoarthritis    cervicitis
    liver cancer    colon cancer    colorectal cancer    prostate cancer
    breast cancer    obesity    fibrosis    hypoxia
    prostatitis    melanoma    hepatitis

    10 Novoseek disease relationships for ZFP36 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 56.7 46 12646273 (2), 11782475 (2), 17599736 (2), 20093488 (2) (see all 26)
    tumors 43.2 62 17855506 (3), 12646273 (2), 12789264 (2), 19491267 (2) (see all 33)
    arthritis 20 5 16262601 (1), 19215754 (1)
    rheumatoid arthritis 18 13 15170914 (2), 15309217 (2), 18536977 (2), 16820934 (1) (see all 7)
    inflammation 15.9 14 18682699 (1), 18481987 (1), 16514065 (1), 19106809 (1) (see all 7)
    autoimmunity 8.2 3 16262601 (1), 12754205 (1)
    hyperplasia 5.84 5 16262601 (1), 19215754 (1)
    cervical cancer 0 3 20157568 (2), 20157555 (1)
    osteoarthritis 0 3 15170914 (1), 16820934 (1)
    cancer 0 7 19491267 (1), 19962963 (1), 17517366 (1), 20335167 (1) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: ZFP36 (2 documents)
    Tumor Gene Database (TGDB): ZFP36

    Export disorders for ZFP36 gene to outside databases

    Publications
    for ZFP36 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFP36 gene, integrated from 9 sources (see all 193):
    (articles sorted by number of sources associating them with ZFP36)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. (PubMed id 15014438)1, 2, 9 Stoecklin G....Anderson P. (2004)
    2. Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis. (PubMed id 16262601)1, 2, 9 Cao H....Blackshear P.J. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes. (PubMed id 2062660)1, 2 Taylor G.A.... Blackshear P.J. (1991)
    5. A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. (PubMed id 1699942)1, 3 DuBois R.N....Nathans D. (1990)
    6. Expression, purification, and biochemical characterization of the antiinflammatory tristetraprolin: a zinc-dependent mRNA binding protein affected by posttranslational modifications. (PubMed id 15504035)1, 9 Cao H. (2004)
    7. Expression of tristetraprolin (G0S24) mRNA, a regulator of tumor necrosis factor-alpha production, in synovial tissues of patients with rheumatoid arthritis. (PubMed id 15170914)1, 9 Tsutsumi A....Sumida T. (2004)
    8. The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway. (PubMed id 15187101)1, 9 Brooks S.A....Rigby W.F. (2004)
    9. Regulation and localization of endogenous human tristetraprolin. (PubMed id 12823857)1, 9 Fairhurst A.M....Wallace P.K. (2003)
    10. The mRNA decay factor tristetraprolin (TTP) induces s enescence in human papillomavirus-transformed cervical cancer cells by targetin g E6-AP ubiquitin ligase. (PubMed id 20157568)1, 9 Sanduja S....Dixon D.A. (2009)

    External Searches for ZFP36 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZFP36 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7538 HGNC: 12862 AceView: ZFP36 Ensembl:ENSG00000128016 euGenes: HUgn7538
    ECgene: ZFP36 H-InvDB: ZFP36

    Other Databases showing ZFP36 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZFP36 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFP36 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/zfp36/

    Intellectual Property
    for ZFP36 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZFP36 gene:
    Search GeneIP for patents involving ZFP36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ZFP36 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ZFP36
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for ZFP36   OriGene shRNA RFP for ZFP36  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFP36   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFP36  
     OriGene Protein Over-expression Lysate for ZFP36   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ZFP36   OriGene 3'-UTR Clone for ZFP36  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP36   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP36  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZFP36   OriGene Custom Protein Services for ZFP36  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZFP36
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFP36
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP36
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFP36
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP36
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFP36
     GenScript Custom Purified and Recombinant Proteins Services for ZFP36 GenScript cDNA clones with any tag delivered in your preferred vector for ZFP36
     GenScript Custom Assay Services for ZFP36 GenScript Custom Superior Antibodies Services for ZFP36
     GenScript Custom overexpressing Cell Line Services for ZFP36 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ZFP36 promoter
     Search Chromatin IP Primers for ZFP36
     RT2 qPCR Primer Assay in human, mouse, rat ZFP36
     GNC Network for ZFP36
     SABiosciences Custom PCR Arrays for ZFP36
     Search Tocris compounds for ZFP36
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ZFP36 antibodies
     ZFP36 proteins
     ZFP36 lysates
     Search for Antibodies for ZFP36 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ZFP36
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ZFP36 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ZFP36
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ZFP36
     SwitchGear 3'UTR luciferase reporter plasmids for ZFP36
     SwitchGear Promoter luciferase reporter plasmids for ZFP36
     Search ThermoFisher Antibodies for ZFP36
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP36
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ZFP36 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4