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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFP36 Gene

protein-coding   GIFtS: 64
GCID: GC19P039897

ZFP36 Ring Finger Protein

(Previous names: zinc finger protein 36, C3H type, homolog (mouse))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ZFP36 Ring Finger Protein1 2     NUP4752
TTP2 3 5     tristetraprolin2
Growth Factor-Inducible Nuclear Protein NUP4752 3     tristetraproline2
Zinc Finger Protein 36 Homolog2 3     zfp-362
G0S242 3     Zinc Finger Protein 36, C3H Type, Homolog2
RNF162A2 3     Zinc Finger Protein, C3H Type, 36 Homolog2
TIS112 3     TIS11A3
G0/G1 Switch Regulatory Protein 242 3     Zfp-363
Zinc Finger Protein 36, C3H Type, Homolog (Mouse)1     Protein TIS11A3
GOS242     

External Ids:    HGNC: 128621   Entrez Gene: 75382   Ensembl: ENSG000001280167   OMIM: 1907005   UniProtKB: P266513   

Export aliases for ZFP36 gene to outside databases

Previous GC identifers: GC19P040538 GC19P040288 GC19P044573 GC19P044589 GC19P036344


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZFP36 Gene: 
ZFP36 (ZFP36 ring finger protein) is a protein-coding gene. Diseases associated with ZFP36 include cervical cancer, and rheumatoid arthritis, and among its related super-pathways are Metabolism of RNA and Destabilization of mRNA by Butyrate Response Factor 1 (BRF1). GO annotations related to this gene include single-stranded RNA binding and protein kinase binding. An important paralog of this gene is ZFP36L1.

UniProtKB/Swiss-Prot: TTP_HUMAN, P26651
Function: mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing
mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase
CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the
post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional
regulation of tumor necrosis factor (TNF)

Gene Wiki entry for ZFP36 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFP36 gene promoter:
         c-Fos   Sp1   AP-1   p300   ATF-2   c-Jun   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFP36 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFP36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

ZFP36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP36 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P039897:  view genomic region     (about GC identifiers)

Start:
39,897,453 bp from pter      End:
39,900,052 bp from pter
Size:
2,600 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TTP_HUMAN, P26651 (See protein sequence)
Recommended Name: Tristetraprolin  
Size: 326 amino acids; 34003 Da
Subunit: Interacts with CNOT1 (By similarity)
Subcellular location: Nucleus. Cytoplasm. Note=Localizes to stress granules upon energy starvation.
phosphorylation by MAPKAPK2 promotes exclusion from stress granules
1 PDB 3D structure from and Proteopedia for ZFP36:
4J8S (3D)    
Secondary accessions: B2RA54

Explore the universe of human proteins at neXtProt for ZFP36: NX_P26651

Explore proteomics data for ZFP36 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation by MAPKAPK2 increases its stability and binding to 14-3-3 proteins, leading to reduce its ARE
    affinity leading to inhibition of degradation of ARE-containing transcripts. Phosphorylated upon mitogen
    stimulation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P26651

  • ZFP36 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFP36 Protein Expression
    REFSEQ proteins: NP_003398.2  
    ENSEMBL proteins: 
     ENSP00000469647   ENSP00000472329   ENSP00000471239   ENSP00000470200   ENSP00000248673  
    Reactome Protein details: P26651
    Human Recombinant Protein Products for ZFP36: 
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    Cloud-Clone Corp. Proteins for ZFP36 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10330172
    GO:0005737cytoplasm IDA10330172
    GO:0005829cytosol TAS--
    GO:0010494cytoplasmic stress granule IDA15014438

    ZFP36 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for ZFP36


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    1 InterPro protein domain:
     IPR000571 Znf_CCCH

    Graphical View of Domain Structure for InterPro Entry P26651

    ProtoNet protein and cluster: P26651

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: TTP_HUMAN, P26651
    Similarity: Contains 2 C3H1-type zinc fingers


    ZFP36 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTP_HUMAN, P26651
    Function: mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing
    mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase
    CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the
    post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional
    regulation of tumor necrosis factor (TNF)
    Induction: By stimulation with various mitogens

         Genatlas biochemistry entry for ZFP36:
    zinc finger protein,proline rich,insulin and growth factor inducible,homologous to mouse tristetraprolin (ZFp-36)

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003727single-stranded RNA binding TAS9703499
    GO:0003729mRNA binding IDA11782475
    GO:0005515protein binding IPI16364915
         
    ZFP36 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZFP36:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         15 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Zfp36):
     adipose tissue  behavior/neurological  cardiovascular system  digestive/alimentary  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  renal/urinary system  respiratory system  skeleton  vision/eye 

    ZFP36 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zfp36tm1Pjb for ZFP36

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFP36 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZFP36

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZFP36 
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    SwitchGear 3'UTR luciferase reporter plasmidZFP36 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZFP36 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    2Destabilization of mRNA by Tristetraprolin (TTP)
    Destabilization of mRNA by Tristetraprolin (TTP)0.79
    3CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.63
    4Generic Transcription Pathway
    Gene Expression0.47
    5Spinal Cord Injury
    Spinal Cord Injury

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for ZFP36
        Spinal Cord Injury
    ErbB1 downstream signaling

    5        Reactome Pathways for ZFP36
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    Destabilization of mRNA by Tristetraprolin (TTP)
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression


    1         Kegg Pathway  (Kegg details for ZFP36):
        HTLV-I infection


    ZFP36 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZFP36

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/43 Interacting proteins for ZFP36 (P266511, 2, 3 ENSP000002486734) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-67159 I2D: score=5 STRING: ENSP00000311695
    DCP1AQ9NPI61, 3EBI-374248,EBI-374238 I2D: score=1 
    EDC3Q96F861, 3, ENSP000003205034EBI-374248,EBI-997311 I2D: score=2 STRING: ENSP00000320503
    UPF2Q9HAU53, ENSP000003487084I2D: score=3 STRING: ENSP00000348708
    EXOSC6Q5RKV63, ENSP000003985974I2D: score=2 STRING: ENSP00000398597
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006402mRNA catabolic process IDA10330172

    ZFP36 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZFP36 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFP36 (TTP)

    10/13 Novoseek inferred chemical compound relationships for ZFP36 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 66.1 87 20052970 (5), 17105199 (3), 15117938 (3), 10072766 (2) (see all 32)
    actinomycin d 37 5 19925787 (2), 16982682 (1), 18523301 (1)
    adenine 36 4 19435930 (1), 17599736 (1), 1627834 (1)
    cycloheximide 29.2 3 16982682 (1), 9539105 (1), 17369404 (1)
    infliximab 27 2 17599736 (2)
    butyrate 24.9 6 10367403 (3), 12198173 (1), 16982678 (1)
    adenylate 22.2 9 12748283 (3), 17855506 (1), 17964608 (1), 15117938 (1) (see all 5)
    mifepristone 19.3 1 16982682 (1)
    arsenite 18.6 2 15944294 (1), 16982678 (1)
    12-o-tetradecanoylphorbol 13-acetate 13.1 3 1996120 (2), 7615073 (1)

    Search CenterWatch for drugs/clinical trials and news about ZFP36 / TTP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFP36 gene: 
    NM_003407.3  

    Unigene Cluster for ZFP36:

    ZFP36 ring finger protein
    Hs.534052  [show with all ESTs]
    Unigene Representative Sequence: NM_003407
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000597629 ENST00000594045 ENST00000594442 ENST00000600033 ENST00000248673(uc002olh.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK314042.1 BC009693.1 M63625.1 M92843.1 

    24/34 DOTS entries (see all 34):

    DT.95370479  DT.100692470  DT.121415663  DT.100846146  DT.452147  DT.92451941  DT.100684836  DT.100846149 
    DT.100846168  DT.40255181  DT.100846153  DT.100760728  DT.121415753  DT.121415642  DT.40261034  DT.99943256 
    DT.121415831  DT.121415870  DT.95205743  DT.95221092  DT.100838912  DT.100846155  DT.100846157  DT.100846160 

    24/595 AceView cDNA sequences (see all 595):

    CN484323 BX104669 CR612171 AL553674 CR615152 AA805217 CR618597 CR609570 
    AI306504 CR615025 CR604446 AV658201 AL556588 CB162225 CR597638 AA459512 
    H21714 AA454493 BM784982 CR619778 CR597168 NM_003407 BI752066 BM142170 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZFP36    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for ZFP36

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFP36 expression in normal human tissues (normalized intensities)      ZFP36 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGTGGGGG
    ZFP36 Expression
    About this image


    ZFP36 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Smooth Muscle (Muscoskeletal System)
             Human Tracheal Smooth Muscle Cells (HTSMC)   
     
     Peripheral Nervous System (Nervous System)
             ganglia   
     
     Cartilage (Muscoskeletal System)
             Human Annulus Fibrosus Cells (HAFC)   
     
     Lung (Muscoskeletal System)
             Human Tracheal Smooth Muscle Cells (HTSMC)   
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts

    See ZFP36 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFP36

    SOURCE GeneReport for Unigene cluster: Hs.534052
        SABiosciences Custom PCR Arrays for ZFP36
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZFP36 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp361 , 5 zinc finger protein 361, 5 84.7(n)1
    86.16(a)1
      7 (16.72 cM)5
    226951  NM_011756.41  NP_035886.11 
     283767845 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1141301 zgc:114130 51.98(n)
    47.89(a)
      570332  NM_001030247.1  NP_001025418.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tis116
    Tis11 homolog
    18(a)
    1 → many
    X(12553395-12576587)
    worm
    (Caenorhabditis elegans)
    Secernentea mex-66
    C35D6.46
    (see all 16)
    Protein C35D6.4
    (see all 16)
    9(a)
    23(a)
    (see all 16)
    possible ortholog
    possible ortholog
    (see all 16)
    II(9524172-9526366)
    IV(16350990-16351601)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIS11(YLR136C)4 mRNA-binding protein expressed during iron starvation; more   --   12(416658-415801) 850827  NP_013237.1 


    ENSEMBL Gene Tree for ZFP36 (if available)
    TreeFam Gene Tree for ZFP36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFP36 gene
    ZFP36L12  ZFP36L22  
    1 SIMAP similar gene for ZFP36 using alignment to 5 protein entries:     TTP_HUMAN (see all proteins):
    ZFP36L1

    ZFP36 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/99 SNPs in ZFP36 are shown (see all 99)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384247051,2
    C--39895518(+) GAATGC/TGTGAA 1 -- us2k10--------
    rs5655451,2
    C,A,H--39895580(+) CTGGGC/TGAAAG 1 -- us2k13Minor allele frequency- T:0.00NA WA CSA 5
    rs356951181,2
    C--39895680(+) TGACC-/TTTTTT 1 -- us2k11Minor allele frequency- T:0.00CSA 2
    rs178822701,2
    C,F--39895873(+) GTCTCG/ACTCTG 1 -- us2k12Minor allele frequency- A:0.01NS WA 292
    rs178846821,2
    C,F--39896136(+) GGTGTG/AAGCCG 1 -- us2k11Minor allele frequency- A:0.01NS 170
    rs178799481,2
    C,F--39896140(+) TGAGCC/TGGGCA 1 -- us2k12Minor allele frequency- T:0.01NS WA 288
    rs178796691,2
    C,F--39896430(+) CTTATC/GTGTCT 1 -- us2k11Minor allele frequency- G:0.01NS 178
    rs1877963681,2
    --39896619(+) TTTTTC/GTAGAC 1 -- us2k10--------
    rs711695911,2
    C--39896828(+) CTTTC-/AAAAAAA 1 -- us2k11Minor allele frequency- AA:0.00NA 2
    rs741780671,2
    C--39896828(+) CTTTC-/AA/AAA
            
    AAAAA
    2 -- us2k1 cds12NA CSA 4

    HapMap Linkage Disequilibrium report for ZFP36 (39897453 - 39900052 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZFP36:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911685CNV Loss21882294
    nsv911680CNV Loss21882294
    dgv3862n71CNV Loss21882294
    nsv911679CNV Loss21882294
    dgv3860n71CNV Loss21882294
    dgv3861n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): ZFP36
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFP36
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFP36

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 190700    OMIM disorders: --

    19 diseases for ZFP36:    About MalaCards
    cervical cancer    rheumatoid arthritis    arthritis    malignant glioma
    herpes simplex    cervicitis    insulin resistance    hypoxia
    colon cancer    obesity    endotheliitis    glioblastoma
    colorectal cancer    melanoma    prostate cancer    prostatitis
    breast cancer    hepatitis    leukemia


    ZFP36 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for ZFP36 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 56.7 46 12646273 (2), 11782475 (2), 17599736 (2), 20093488 (2) (see all 26)
    tumors 43.2 62 17855506 (3), 12646273 (2), 12789264 (2), 19491267 (2) (see all 33)
    arthritis 20 5 16262601 (1), 19215754 (1)
    rheumatoid arthritis 18 13 15170914 (2), 15309217 (2), 18536977 (2), 16820934 (1) (see all 7)
    inflammation 15.9 14 18682699 (1), 18481987 (1), 16514065 (1), 19106809 (1) (see all 7)
    autoimmunity 8.2 3 16262601 (1), 12754205 (1)
    hyperplasia 5.84 5 16262601 (1), 19215754 (1)
    cervical cancer 0 3 20157568 (2), 20157555 (1)
    osteoarthritis 0 3 15170914 (1), 16820934 (1)
    cancer 0 7 19491267 (1), 19962963 (1), 17517366 (1), 20335167 (1) (see all 5)

    Genetic Association Database (GAD): ZFP36
    Human Genome Epidemiology (HuGE) Navigator: ZFP36 (2 documents)
    Tumor Gene Database (TGDB): ZFP36

    Export disorders for ZFP36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFP36 gene, integrated from 9 sources (see all 205):
    (articles sorted by number of sources associating them with ZFP36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. (PubMed id 15014438)1, 2, 9 Stoecklin G....Anderson P. (2004)
    2. Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis. (PubMed id 16262601)1, 2, 9 Cao H....Blackshear P.J. (2006)
    3. Genetic variations in ZFP36 and their possible relationship to autoimmune diseases. (PubMed id 16546352)1, 4 Carrick D.M....Blackshear P.J. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes. (PubMed id 2062660)1, 2 Taylor G.A.... Blackshear P.J. (1991)
    6. A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. (PubMed id 1699942)1, 3 DuBois R.N....Nathans D. (1990)
    7. Expression, purification, and biochemical characterization of the antiinflammatory tristetraprolin: a zinc-dependent mRNA binding protein affected by posttranslational modifications. (PubMed id 15504035)1, 9 Cao H. (2004)
    8. Expression of tristetraprolin (G0S24) mRNA, a regulator of tumor necrosis factor-alpha production, in synovial tissues of patients with rheumatoid arthritis. (PubMed id 15170914)1, 9 Tsutsumi A....Sumida T. (2004)
    9. The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway. (PubMed id 15187101)1, 9 Brooks S.A....Rigby W.F. (2004)
    10. Regulation and localization of endogenous human tristetraprolin. (PubMed id 12823857)1, 9 Fairhurst A.M....Wallace P.K. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7538 HGNC: 12862 AceView: ZFP36 Ensembl:ENSG00000128016 euGenes: HUgn7538
    ECgene: ZFP36 Kegg: 7538 H-InvDB: ZFP36

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFP36 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/zfp36/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFP36 gene:
    Search GeneIP for patents involving ZFP36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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