Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZFP36 Gene

Aliases for ZFP36 Gene

  • ZFP36 Ring Finger Protein 2 3
  • TTP 3 4 6
  • Growth Factor-Inducible Nuclear Protein NUP475 3 4
  • G0/G1 Switch Regulatory Protein 24 3 4
  • Zinc Finger Protein 36 Homolog 3 4
  • Tristetraprolin 2 3
  • RNF162A 3 4
  • Zfp-36 3 4
  • G0S24 3 4
  • TIS11 3 4
  • Zinc Finger Protein 36, C3H Type, Homolog (Mouse) 2
  • Zinc Finger Protein 36, C3H Type, Homolog 3
  • Zinc Finger Protein, C3H Type, 36 Homolog 3
  • Tristetraproline 3
  • Protein TIS11A 4
  • NUP475 3
  • TIS11A 4
  • GOS24 3

External Ids for ZFP36 Gene

Summaries for ZFP36 Gene

GeneCards Summary for ZFP36 Gene

ZFP36 (ZFP36 Ring Finger Protein) is a Protein Coding gene. Among its related pathways are Spinal Cord Injury and ErbB1 downstream signaling. GO annotations related to this gene include protein kinase binding and single-stranded RNA binding. An important paralog of this gene is ZFP36L2.

UniProtKB/Swiss-Prot for ZFP36 Gene

  • mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).

Gene Wiki entry for ZFP36 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP36 Gene

Genomics for ZFP36 Gene

Genomic Location for ZFP36 Gene

Start:
39,406,813 bp from pter
End:
39,409,412 bp from pter
Size:
2,600 bases
Orientation:
Plus strand

Genomic View for ZFP36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFP36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP36 Gene

Regulatory Elements for ZFP36 Gene

Proteins for ZFP36 Gene

  • Protein details for ZFP36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26651-TTP_HUMAN
    Recommended name:
    Tristetraprolin
    Protein Accession:
    P26651
    Secondary Accessions:
    • B2RA54

    Protein attributes for ZFP36 Gene

    Size:
    326 amino acids
    Molecular mass:
    34003 Da
    Quaternary structure:
    • Interacts (via C-terminus) with CNOT1.

    Three dimensional structures from OCA and Proteopedia for ZFP36 Gene

neXtProt entry for ZFP36 Gene

Proteomics data for ZFP36 Gene at MOPED

Post-translational modifications for ZFP36 Gene

  • Phosphorylation by MAPKAPK2 increases its stability and binding to 14-3-3 proteins, leading to reduce its ARE affinity leading to inhibition of degradation of ARE-containing transcripts. Phosphorylated upon mitogen stimulation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP36 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFP36 Gene

Domains for ZFP36 Gene

Gene Families for ZFP36 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for ZFP36 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TTP_HUMAN
Similarity:
  • Contains 2 C3H1-type zinc fingers.:
    • P26651
genes like me logo Genes that share domains with ZFP36: view

Function for ZFP36 Gene

Molecular function for ZFP36 Gene

GENATLAS Biochemistry: zinc finger protein,proline rich,insulin and growth factor inducible,homologous to mouse tristetraprolin (ZFp-36)
UniProtKB/Swiss-Prot Function: mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).
UniProtKB/Swiss-Prot Induction: By stimulation with various mitogens

Gene Ontology (GO) - Molecular Function for ZFP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003727 single-stranded RNA binding TAS 9703499
GO:0003729 mRNA binding IDA 11782475
GO:0005515 protein binding IPI 16364915
GO:0017091 AU-rich element binding IMP 21784977
genes like me logo Genes that share ontologies with ZFP36: view
genes like me logo Genes that share phenotypes with ZFP36: view

Animal Models for ZFP36 Gene

MGI Knock Outs for ZFP36:

miRNA for ZFP36 Gene

miRTarBase miRNAs that target ZFP36

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZFP36 Gene

Localization for ZFP36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP36 Gene

Nucleus. Cytoplasm. Note=Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP36 Gene COMPARTMENTS Subcellular localization image for ZFP36 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for ZFP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10330172
GO:0005737 cytoplasm IDA 10330172
GO:0005829 cytosol TAS --
GO:0010494 cytoplasmic stress granule IDA 15014438
genes like me logo Genes that share ontologies with ZFP36: view

Pathways for ZFP36 Gene

genes like me logo Genes that share pathways with ZFP36: view

Pathways by source for ZFP36 Gene

Interacting Proteins for ZFP36 Gene

Gene Ontology (GO) - Biological Process for ZFP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 21784977
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA 23644599
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening IMP 23644599
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006402 mRNA catabolic process IDA 10330172
genes like me logo Genes that share ontologies with ZFP36: view

Compounds for ZFP36 Gene

(13) Novoseek inferred chemical compound relationships for ZFP36 Gene

Compound -log(P) Hits PubMed IDs
zinc 66.1 48
actinomycin d 37 4
adenine 36 3
cycloheximide 29.2 3
infliximab 27 2
genes like me logo Genes that share compounds with ZFP36: view

Transcripts for ZFP36 Gene

mRNA/cDNA for ZFP36 Gene

Unigene Clusters for ZFP36 Gene

ZFP36 ring finger protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP36 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for ZFP36 Gene

GeneLoc Exon Structure for
ZFP36
ECgene alternative splicing isoforms for
ZFP36

Expression for ZFP36 Gene

mRNA expression in normal human tissues for ZFP36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZFP36 Gene

This gene is overexpressed in Fallopian Tube (4.6).

SOURCE GeneReport for Unigene cluster for ZFP36 Gene Hs.534052

genes like me logo Genes that share expressions with ZFP36: view

Orthologs for ZFP36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFP36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP36 36
  • 99.58 (n)
  • 99.69 (a)
ZFP36 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFP36 36
  • 84 (n)
  • 85.14 (a)
ZFP36 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP36 36
  • 84.35 (n)
  • 83.79 (a)
ZFP36 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp36 36
  • 84.65 (n)
  • 86.44 (a)
Zfp36 16
Zfp36 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFP36 37
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp36 36
  • 85.44 (n)
  • 86.15 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zfp36 36
  • 53.28 (n)
  • 53.69 (a)
zebrafish
(Danio rerio)
Actinopterygii ZFP36 37
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tis11 37
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C35D6.4 37
  • 23 (a)
ManyToMany
ccch-1 37
  • 17 (a)
ManyToMany
ccch-2 37
  • 28 (a)
ManyToMany
ccch-5 37
  • 25 (a)
ManyToMany
dct-13 37
  • 20 (a)
ManyToMany
F38C2.7 37
  • 21 (a)
ManyToMany
mex-1 37
  • 15 (a)
ManyToMany
mex-5 37
  • 12 (a)
ManyToMany
mex-6 37
  • 11 (a)
ManyToMany
moe-3 37
  • 19 (a)
ManyToMany
oma-1 37
  • 16 (a)
ManyToMany
oma-2 37
  • 16 (a)
ManyToMany
pos-1 37
  • 19 (a)
ManyToMany
Y116A8C.19 37
  • 23 (a)
ManyToMany
Y116A8C.20 37
  • 22 (a)
ManyToMany
Y60A9.3 37
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTH1 37
  • 15 (a)
ManyToMany
TIS11 37
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6084 37
  • 22 (a)
OneToMany
Species with no ortholog for ZFP36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFP36 Gene

ENSEMBL:
Gene Tree for ZFP36 (if available)
TreeFam:
Gene Tree for ZFP36 (if available)

Paralogs for ZFP36 Gene

Paralogs for ZFP36 Gene

Selected SIMAP similar genes for ZFP36 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZFP36: view

Variants for ZFP36 Gene

Sequence variations from dbSNP and Humsavar for ZFP36 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs251864 -- 39,406,653(+) CGGTC(A/G)CGGCT upstream-variant-2KB
rs565545 -- 39,404,940(+) CTGGG(C/T)GAAAG upstream-variant-2KB
rs1803662 -- 39,409,041(+) GCCTT(A/C)ACTGC utr-variant-3-prime
rs2229272 - 39,407,881(+) GCCTG(C/T)CTGGC reference, missense
rs3746083 -- 39,408,027(+) TCGCG(A/C/G/T)TACAA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ZFP36 Gene

Variant ID Type Subtype PubMed ID
nsv911679 CNV Loss 21882294
nsv911680 CNV Loss 21882294
dgv3860n71 CNV Loss 21882294
dgv3861n71 CNV Loss 21882294
nsv911685 CNV Loss 21882294
dgv3862n71 CNV Loss 21882294

Relevant External Links for ZFP36 Gene

HapMap Linkage Disequilibrium report
ZFP36
Human Gene Mutation Database (HGMD)
ZFP36

Disorders for ZFP36 Gene

(10) Novoseek inferred disease relationships for ZFP36 Gene

Disease -log(P) Hits PubMed IDs
necrosis 56.7 31
tumors 43.2 42
arthritis 20 2
rheumatoid arthritis 18 10
inflammation 15.9 7

Relevant External Links for ZFP36

Genetic Association Database (GAD)
ZFP36
Human Genome Epidemiology (HuGE) Navigator
ZFP36
Tumor Gene Database (TGDB):
ZFP36
genes like me logo Genes that share disorders with ZFP36: view

No data available for UniProtKB/Swiss-Prot for ZFP36 Gene

Publications for ZFP36 Gene

  1. MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. (PMID: 15014438) Stoecklin G. … Anderson P. (EMBO J. 2004) 3 4 23
  2. Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis. (PMID: 16262601) Cao H. … Blackshear P.J. (Biochem. J. 2006) 3 4 23
  3. Polymorphisms in the genes encoding members of the tristetraprolin family of human tandem CCCH zinc finger proteins. (PMID: 14604009) Blackshear P.J. … Mohrenweiser H. (Prog. Nucleic Acid Res. Mol. Biol. 2003) 3 23
  4. Direct association of tristetraprolin with the nucleoporin CAN/Nup214. (PMID: 14766228) Carman J.A. … Nadler S.G. (Biochem. Biophys. Res. Commun. 2004) 3 23
  5. Tristetraprolin regulates the expression of the human inducible nitric-oxide synthase gene. (PMID: 15778452) Fechir M. … Kleinert H. (Mol. Pharmacol. 2005) 3 23

Products for ZFP36 Gene

Sources for ZFP36 Gene

Back to Top

Content