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ZFP36 Gene

protein-coding   GIFtS: 64
GCID: GC19P039897

ZFP36 Ring Finger Protein

(Previous names: zinc finger protein 36, C3H type, homolog (mouse))
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ZFP36 Ring Finger Protein1 2     NUP4752
TTP2 3 5     tristetraprolin2
Growth Factor-Inducible Nuclear Protein NUP4752 3     tristetraproline2
Zinc Finger Protein 36 Homolog2 3     zfp-362
G0S242 3     Zinc Finger Protein 36, C3H Type, Homolog2
RNF162A2 3     Zinc Finger Protein, C3H Type, 36 Homolog2
TIS112 3     TIS11A3
G0/G1 Switch Regulatory Protein 242 3     Zfp-363
Zinc Finger Protein 36, C3H Type, Homolog (Mouse)1     Protein TIS11A3
GOS242     

External Ids:    HGNC: 128621   Entrez Gene: 75382   Ensembl: ENSG000001280167   OMIM: 1907005   UniProtKB: P266513   

Export aliases for ZFP36 gene to outside databases

Previous GC identifers: GC19P040538 GC19P040288 GC19P044573 GC19P044589 GC19P036344


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZFP36 Gene:
ZFP36 (ZFP36 ring finger protein) is a protein-coding gene. Diseases associated with ZFP36 include cervical cancer, and rheumatoid arthritis. GO annotations related to this gene include single-stranded RNA binding and protein kinase binding. An important paralog of this gene is ZFP36L1.

UniProtKB/Swiss-Prot: TTP_HUMAN, P26651
Function: mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing
mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase
CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the
post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional
regulation of tumor necrosis factor (TNF)

Gene Wiki entry for ZFP36 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFP36 gene promoter:
         c-Fos   Sp1   AP-1   p300   ATF-2   c-Jun   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFP36 promoter sequence
   Search Chromatin IP Primers for ZFP36

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFP36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1

ZFP36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP36 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P039897:  view genomic region     (about GC identifiers)

Start:
39,897,453 bp from pter      End:
39,900,052 bp from pter
Size:
2,600 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TTP_HUMAN, P26651 (See protein sequence)
Recommended Name: Tristetraprolin  
Size: 326 amino acids; 34003 Da
Subunit: Interacts (via C-terminus) with CNOT1
1 PDB 3D structure from and Proteopedia for ZFP36:
4J8S (3D)    
Secondary accessions: B2RA54

Explore the universe of human proteins at neXtProt for ZFP36: NX_P26651

Explore proteomics data for ZFP36 at MOPED

Post-translational modifications: 

  • Phosphorylation by MAPKAPK2 increases its stability and binding to 14-3-3 proteins, leading to reduce its ARE
    affinity leading to inhibition of degradation of ARE-containing transcripts. Phosphorylated upon mitogen
    stimulation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZFP36 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003398.2  
    ENSEMBL proteins: 
     ENSP00000469647   ENSP00000472329   ENSP00000471239   ENSP00000470200   ENSP00000248673  
    Reactome Protein details: P26651

    ZFP36 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ZFP36

    ZFP36 Antibody Products:

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    ZFP36 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ZFP36
    Cloud-Clone Corp. CLIAs for ZFP36


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    1 InterPro protein domain:
     IPR000571 Znf_CCCH

    Graphical View of Domain Structure for InterPro Entry P26651

    ProtoNet protein and cluster: P26651

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: TTP_HUMAN, P26651
    Similarity: Contains 2 C3H1-type zinc fingers


    ZFP36 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTP_HUMAN, P26651
    Function: mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing
    mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase
    CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the
    post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional
    regulation of tumor necrosis factor (TNF)
    Induction: By stimulation with various mitogens

         Genatlas biochemistry entry for ZFP36:
    zinc finger protein,proline rich,insulin and growth factor inducible,homologous to mouse tristetraprolin (ZFp-36)

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003727single-stranded RNA binding TAS9703499
    GO:0003729mRNA binding IDA11782475
    GO:0005515protein binding IPI16364915
    GO:0017091AU-rich element binding IMP--
         
    ZFP36 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZFP36:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         15 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Zfp36):
     adipose tissue  behavior/neurological  cardiovascular system  digestive/alimentary  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  renal/urinary system  respiratory system  skeleton  vision/eye 

    ZFP36 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zfp36tm1Pjb for ZFP36

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZFP36
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZFP36

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZFP36
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZFP36

    miRNA
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    hsa-mir-346 (MIRT016689)

    Block miRNA regulation of human, mouse, rat ZFP36 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFP36 (see all 26):
    hsa-miR-142-5p hsa-miR-520d-5p hsa-miR-551a hsa-miR-513a-5p hsa-miR-29c hsa-miR-29a hsa-miR-548v hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidZFP36 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ZFP36
    Predesigned siRNA for gene silencing in human, mouse, rat ZFP36

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP36

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP36


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TTP_HUMAN, P26651: Nucleus. Cytoplasm. Note=Localizes to stress granules upon energy starvation.
    phosphorylation by MAPKAPK2 promotes exclusion from stress granules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10330172
    GO:0005737cytoplasm IDA10330172
    GO:0005829cytosol TAS--
    GO:0010494cytoplasmic stress granule IDA15014438

    ZFP36 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZFP36 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62
    Destabilization of mRNA by Tristetraprolin (TTP)0.00
    2Gene Expression
    Gene Expression0.40
    3Spinal Cord Injury
    Spinal Cord Injury
    4HTLV-I infection
    HTLV-I infection
    5ErbB1 downstream signaling
    ErbB1 downstream signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for ZFP36
        Spinal Cord Injury
    ErbB1 downstream signaling

    1 Reactome Pathway for ZFP36
        Tristetraprolin (TTP) destabilizes mRNA


    1 Kegg Pathway  (Kegg details for ZFP36):
        HTLV-I infection


    ZFP36 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFP36
    Interactions:

        GeneGlobe Interaction Network for ZFP36

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZFP36 (P266511, 2, 3 ENSP000002486734) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-67159 I2D: score=5 STRING: ENSP00000311695
    DCP1AQ9NPI61, 3EBI-374248,EBI-374238 I2D: score=1 
    EDC3Q96F861, 3, ENSP000003205034EBI-374248,EBI-997311 I2D: score=2 STRING: ENSP00000320503
    UPF2Q9HAU53, ENSP000003487084I2D: score=3 STRING: ENSP00000348708
    EXOSC6Q5RKV63, ENSP000003985974I2D: score=2 STRING: ENSP00000398597
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006402mRNA catabolic process IDA10330172

    ZFP36 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFP36 (TTP)

    Selected Novoseek inferred chemical compound relationships for ZFP36 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 66.1 87 20052970 (5), 17105199 (3), 15117938 (3), 10072766 (2) (see all 32)
    actinomycin d 37 5 19925787 (2), 16982682 (1), 18523301 (1)
    adenine 36 4 19435930 (1), 17599736 (1), 1627834 (1)
    cycloheximide 29.2 3 16982682 (1), 9539105 (1), 17369404 (1)
    infliximab 27 2 17599736 (2)
    butyrate 24.9 6 10367403 (3), 12198173 (1), 16982678 (1)
    adenylate 22.2 9 12748283 (3), 17855506 (1), 17964608 (1), 15117938 (1) (see all 5)
    mifepristone 19.3 1 16982682 (1)
    arsenite 18.6 2 15944294 (1), 16982678 (1)
    12-o-tetradecanoylphorbol 13-acetate 13.1 3 1996120 (2), 7615073 (1)



    ZFP36 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZFP36 gene: 
    NM_003407.3  

    Unigene Cluster for ZFP36:

    ZFP36 ring finger protein
    Hs.534052  [show with all ESTs]
    Unigene Representative Sequence: NM_003407
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000597629 ENST00000594045 ENST00000594442 ENST00000600033 ENST00000248673(uc002olh.1)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZFP36 (see all 26):
    hsa-miR-142-5p hsa-miR-520d-5p hsa-miR-551a hsa-miR-513a-5p hsa-miR-29c hsa-miR-29a hsa-miR-548v hsa-miR-410
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      QuantiFast Probe-based Assays in human, mouse, rat ZFP36

    Additional mRNA sequence: 

    AK314042.1 BC009693.1 M63625.1 M92843.1 

    Selected DOTS entries (see all 34):

    DT.95370479  DT.100692470  DT.121415663  DT.100846146  DT.452147  DT.92451941  DT.100684836  DT.100846149 
    DT.100846168  DT.40255181  DT.100846153  DT.100760728  DT.121415753  DT.121415642  DT.40261034  DT.99943256 
    DT.121415831  DT.121415870  DT.95205743  DT.95221092  DT.100838912  DT.100846155  DT.100846157  DT.100846160 

    Selected AceView cDNA sequences (see all 595):

    BM819022 CR617754 BP362596 AL544168 BX336360 BU151092 AA805217 AA459283 
    BG413402 BU150664 BE465739 BI962605 BI793300 BM142170 AI332376 BX382849 
    BG696010 CR603935 CR620571 BQ220026 AI628749 CR618597 CB162225 AA257073 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZFP36    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for ZFP36

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFP36 expression in normal human tissues (normalized intensities)      ZFP36 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGTGGGGG
    ZFP36 Expression
    About this image


    ZFP36 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Ovary (Reproductive System)
             Secondary follicles
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Bone (Muscoskeletal System)
             Bone Marrow
    ZFP36 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFP36 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534052
        Custom PCR Arrays for ZFP36
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP36

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZFP36 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp361 , 5 zinc finger protein 361, 5 84.65(n)1
    86.44(a)1
      7 (16.72 cM)5
    226951  NM_011756.41  NP_035886.11 
     283767845 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia zfp361 ZFP36 ring finger protein 53.28(n)
    53.69(a)
      100127733  NM_001113071.1  NP_001106542.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ZFP366
    ZFP36 ring finger protein
    30(a)
    1 ↔ 1
    Zv9_NA234(5622-7517) ENSDARG00000044395
    fruit fly
    (Drosophila melanogaster)
    Insecta Tis116
    Tis11 homolog
    21(a)
    1 → many
    X(12553395-12576587)
    worm
    (Caenorhabditis elegans)
    Secernentea ccch-26
    ccch-56
    (see all 16)
    Protein CCCH-5 (ccch-5) mRNA, complete cds
    (see all 16)
    28(a)
    25(a)
    (see all 16)
    many ↔ many
    many ↔ many
    (see all 16)
    IV(16278213-16279018) WBGene00009537
    IV(14919624-14920423) WBGene00013319
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIS11(YLR136C)4 mRNA-binding protein expressed during iron starvation; more   --   12(416658-415801) 850827  NP_013237.1 


    ENSEMBL Gene Tree for ZFP36 (if available)
    TreeFam Gene Tree for ZFP36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZFP36 gene
    ZFP36L12  ZFP36L22  
    1 SIMAP similar gene for ZFP36 using alignment to 5 protein entries:     TTP_HUMAN (see all proteins):
    ZFP36L1

    ZFP36 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFP36 (see all 99)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384247051,2
    C--39895518(+) GAATGC/TGTGAA 1 -- us2k10--------
    rs5655451,2
    C,A,H--39895580(+) CTGGGC/TGAAAG 1 -- us2k13Minor allele frequency- T:0.00NA WA CSA 5
    rs356951181,2
    C--39895680(+) TGACC-/TTTTTT 1 -- us2k11Minor allele frequency- T:0.00CSA 2
    rs178822701,2
    C,F--39895873(+) GTCTCG/ACTCTG 1 -- us2k12Minor allele frequency- A:0.01NS WA 292
    rs178846821,2
    C,F--39896136(+) GGTGTG/AAGCCG 1 -- us2k11Minor allele frequency- A:0.01NS 170
    rs178799481,2
    C,F--39896140(+) TGAGCC/TGGGCA 1 -- us2k12Minor allele frequency- T:0.01NS WA 288
    rs178796691,2
    C,F--39896430(+) CTTATC/GTGTCT 1 -- us2k11Minor allele frequency- G:0.01NS 178
    rs1877963681,2
    --39896619(+) TTTTTC/GTAGAC 1 -- us2k10--------
    rs711695911,2
    C--39896828(+) CTTTC-/AAAAAAA 1 -- us2k11Minor allele frequency- AA:0.00NA 2
    rs741780671,2
    C--39896828(+) CTTTC-/AA/AAA
            
    AAAAA
    2 -- us2k1 cds12NA CSA 4

    HapMap Linkage Disequilibrium report for ZFP36 (39897453 - 39900052 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZFP36:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911685CNV Loss21882294
    nsv911680CNV Loss21882294
    dgv3862n71CNV Loss21882294
    nsv911679CNV Loss21882294
    dgv3860n71CNV Loss21882294
    dgv3861n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): ZFP36
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFP36
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFP36

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 190700    OMIM disorders: --

    Selected diseases for ZFP36 (see all 23):    About MalaCards
    cervical cancer    rheumatoid arthritis    cervicitis    spinal cord injury
    malignant glioma    arthritis    herpes simplex    osteoarthritis
    insulin resistance    hypoxia    cystic fibrosis    obesity
    endotheliitis    colorectal cancer    melanoma    prostate cancer
    prostatitis    breast cancer    squamous cell carcinoma    hiv-1


    ZFP36 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for ZFP36 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 56.7 46 12646273 (2), 11782475 (2), 17599736 (2), 20093488 (2) (see all 26)
    tumors 43.2 62 17855506 (3), 12646273 (2), 12789264 (2), 19491267 (2) (see all 33)
    arthritis 20 5 16262601 (1), 19215754 (1)
    rheumatoid arthritis 18 13 15170914 (2), 15309217 (2), 18536977 (2), 16820934 (1) (see all 7)
    inflammation 15.9 14 18682699 (1), 18481987 (1), 16514065 (1), 19106809 (1) (see all 7)
    autoimmunity 8.2 3 16262601 (1), 12754205 (1)
    hyperplasia 5.84 5 16262601 (1), 19215754 (1)
    cervical cancer 0 3 20157568 (2), 20157555 (1)
    osteoarthritis 0 3 15170914 (1), 16820934 (1)
    cancer 0 7 19491267 (1), 19962963 (1), 17517366 (1), 20335167 (1) (see all 5)

    Genetic Association Database (GAD): ZFP36
    Human Genome Epidemiology (HuGE) Navigator: ZFP36 (2 documents)
    Tumor Gene Database (TGDB): ZFP36

    Export disorders for ZFP36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFP36 gene, integrated from 10 sources (see all 209):
    (articles sorted by number of sources associating them with ZFP36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. (PubMed id 15014438)1, 2, 9 Stoecklin G.... Anderson P. (EMBO J. 2004)
    2. Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis. (PubMed id 16262601)1, 2, 9 Cao H.... Blackshear P.J. (Biochem. J. 2006)
    3. Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin. (PubMed id 23644599)1, 2 Fabian M.R....Sonenberg N. (amp 2013)
    4. Genetic variations in ZFP36 and their possible relationship to autoimmune diseases. (PubMed id 16546352)1, 4 Carrick D.M....Blackshear P.J. (J. Autoimmun. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes. (PubMed id 2062660)1, 2 Taylor G.A.... Blackshear P.J. (Nucleic Acids Res. 1991)
    7. A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. (PubMed id 1699942)1, 3 DuBois R.N....Nathans D. (J. Biol. Chem. 1990)
    8. Expression, purification, and biochemical characterization of the antiinflammatory tristetraprolin: a zinc-dependent mRNA binding protein affected by posttranslational modifications. (PubMed id 15504035)1, 9 Cao H. (Biochemistry 2004)
    9. Expression of tristetraprolin (G0S24) mRNA, a regulator of tumor necrosis factor-alpha production, in synovial tissues of patients with rheumatoid arthritis. (PubMed id 15170914)1, 9 Tsutsumi A....Sumida T. (J. Rheumatol. 2004)
    10. The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway. (PubMed id 15187101)1, 9 Brooks S.A....Rigby W.F. (J. Immunol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7538 HGNC: 12862 AceView: ZFP36 Ensembl:ENSG00000128016 euGenes: HUgn7538
    ECgene: ZFP36 Kegg: 7538 H-InvDB: ZFP36

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZFP36 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/zfp36/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFP36 gene:
    Search GeneIP for patents involving ZFP36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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