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Aliases for ZFP30 Gene

Aliases for ZFP30 Gene

  • ZFP30 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 745 3 4
  • ZNF745 3 4
  • Zinc Finger Protein 30 Homolog (Mouse) 2
  • Zinc Finger Protein 30 Homolog 3
  • KIAA0961 4
  • Zfp-30 4

External Ids for ZFP30 Gene

Previous GeneCards Identifiers for ZFP30 Gene

  • GC19M042799
  • GC19M042815
  • GC19U900417
  • GC19M038123
  • GC19M034573

Summaries for ZFP30 Gene

GeneCards Summary for ZFP30 Gene

ZFP30 (ZFP30 Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZFP82.

UniProtKB/Swiss-Prot for ZFP30 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP30 Gene

Genomics for ZFP30 Gene

Regulatory Elements for ZFP30 Gene

Enhancers for ZFP30 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZFP30 on UCSC Golden Path with GeneCards custom track

Promoters for ZFP30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ZFP30 Gene

Chromosome:
19
Start:
37,613,749 bp from pter
End:
37,692,337 bp from pter
Size:
78,589 bases
Orientation:
Minus strand

Genomic View for ZFP30 Gene

Genes around ZFP30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP30 Gene

Proteins for ZFP30 Gene

  • Protein details for ZFP30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2G7-ZFP30_HUMAN
    Recommended name:
    Zinc finger protein 30 homolog
    Protein Accession:
    Q9Y2G7
    Secondary Accessions:
    • Q58EY8

    Protein attributes for ZFP30 Gene

    Size:
    519 amino acids
    Molecular mass:
    61558 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76805.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZFP30 Gene

Post-translational modifications for ZFP30 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFP30 Gene

Domains & Families for ZFP30 Gene

Gene Families for ZFP30 Gene

Protein Domains for ZFP30 Gene

Suggested Antigen Peptide Sequences for ZFP30 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2G7

UniProtKB/Swiss-Prot:

ZFP30_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFP30: view

Function for ZFP30 Gene

Molecular function for ZFP30 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZFP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP30: view

Phenotypes for ZFP30 Gene

genes like me logo Genes that share phenotypes with ZFP30: view

Animal Model Products

CRISPR Products

miRNA for ZFP30 Gene

miRTarBase miRNAs that target ZFP30

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP30 Gene

Localization for ZFP30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP30 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP30 Gene COMPARTMENTS Subcellular localization image for ZFP30 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZFP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP30: view

Pathways & Interactions for ZFP30 Gene

SuperPathways for ZFP30 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP30: view

Pathways by source for ZFP30 Gene

2 Reactome pathways for ZFP30 Gene

Interacting Proteins for ZFP30 Gene

Gene Ontology (GO) - Biological Process for ZFP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZFP30: view

No data available for SIGNOR curated interactions for ZFP30 Gene

Drugs & Compounds for ZFP30 Gene

No Compound Related Data Available

Transcripts for ZFP30 Gene

mRNA/cDNA for ZFP30 Gene

(7) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP30 Gene

ZFP30 zinc finger protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP30 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP1: - - - - -
SP2: - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - - -
SP7: -

Relevant External Links for ZFP30 Gene

GeneLoc Exon Structure for
ZFP30
ECgene alternative splicing isoforms for
ZFP30

Expression for ZFP30 Gene

mRNA expression in normal human tissues for ZFP30 Gene

Protein differential expression in normal tissues from HIPED for ZFP30 Gene

This gene is overexpressed in Plasma (56.3) and Serum (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZFP30 Gene



Protein tissue co-expression partners for ZFP30 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFP30 Gene:

ZFP30

SOURCE GeneReport for Unigene cluster for ZFP30 Gene:

Hs.716719
genes like me logo Genes that share expression patterns with ZFP30: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFP30 Gene

Orthologs for ZFP30 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP30 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZFP30 34
  • 90.94 (n)
  • 92.29 (a)
-- 35
  • 63 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia ZFP30 34
  • 91.1 (n)
  • 93.37 (a)
ZFP30 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp30 34
  • 79.84 (n)
  • 85.27 (a)
Zfp30 16
Zfp30 35
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZFP30 34
  • 99.68 (n)
  • 99.81 (a)
ZFP30 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910007 34
  • 76.81 (n)
  • 83.72 (a)
Species where no ortholog for ZFP30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP30 Gene

ENSEMBL:
Gene Tree for ZFP30 (if available)
TreeFam:
Gene Tree for ZFP30 (if available)

Paralogs for ZFP30 Gene

(467) SIMAP similar genes for ZFP30 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZFP30: view

Variants for ZFP30 Gene

Sequence variations from dbSNP and Humsavar for ZFP30 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2972446 -- 37,638,992(-) TTTAG(C/T)GTATA intron-variant
rs2972447 -- 37,638,835(-) CTTTC(A/G)GTCAT intron-variant
rs2972453 -- 37,652,872(-) CCAAA(A/G)TGTTG intron-variant
rs2972454 -- 37,652,499(-) cctcc(A/G)cctcc intron-variant
rs2972455 -- 37,649,085(-) AAAAA(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP30 Gene

Variant ID Type Subtype PubMed ID
nsv579468 CNV gain 21841781

Variation tolerance for ZFP30 Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP30 Gene

Disorders for ZFP30 Gene

Relevant External Links for ZFP30

Genetic Association Database (GAD)
ZFP30
Human Genome Epidemiology (HuGE) Navigator
ZFP30
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP30

No disorders were found for ZFP30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP30 Gene

Publications for ZFP30 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 65
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 65
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 65

Products for ZFP30 Gene

Sources for ZFP30 Gene

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