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Aliases for ZFP30 Gene

Aliases for ZFP30 Gene

  • ZFP30 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 745 3 4
  • ZNF745 3 4
  • Zinc Finger Protein 30 Homolog (Mouse) 2
  • Zinc Finger Protein 30 Homolog 3
  • KIAA0961 4
  • Zfp-30 4

External Ids for ZFP30 Gene

Previous GeneCards Identifiers for ZFP30 Gene

  • GC19M042799
  • GC19M042815
  • GC19U900417
  • GC19M038123
  • GC19M034573

Summaries for ZFP30 Gene

GeneCards Summary for ZFP30 Gene

ZFP30 (ZFP30 Zinc Finger Protein) is a Protein Coding gene. Diseases associated with ZFP30 include Cerebral Visual Impairment. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZFP82.

UniProtKB/Swiss-Prot for ZFP30 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP30 Gene

Genomics for ZFP30 Gene

Regulatory Elements for ZFP30 Gene

Enhancers for ZFP30 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G037930 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -246.0 -245981 16.0 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 ZNF143 ZNF793 ZNF607 LINC01535 ZNF585B ZNF781 ZNF585A ENSG00000267152 ZNF420 WDR87 LOC100631378
GH19G037778 1.2 ENCODE 14.6 -87.1 -87059 2.1 CREB3L1 DMAP1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 SP3 ZNF610 GLIS1 ZNF793 ZNF383 ZNF345 ZNF585B ZNF781 LINC01535 ZNF607 ZNF790-AS1 ZNF571 ZNF585A
GH19G037691 1 ENCODE 14.8 +0.2 225 1.5 PKNOX1 ATF1 CREB3L1 SIN3A ARID4B DMAP1 ZNF48 YY1 ZNF143 ZHX2 LINC01535 ZNF607 ZFP30 ZNF781 PIR37882
GH19G037926 1.5 Ensembl ENCODE dbSUPER 9.6 -235.7 -235712 4.0 HDGF ATF1 PKNOX1 SIN3A ZNF121 GLIS2 ELK1 KLF13 KDM4B ZNF263 LINC01535 WDR87 ZNF420 ZNF571 ZNF573 ZNF585A ZNF383 ENSG00000267152 LOC100631378 ENSG00000267672
GH19G037905 1.4 ENCODE dbSUPER 9.5 -215.4 -215381 4.2 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF416 ZNF143 ZNF585B LINC01535 ZNF607 WDR87 ZNF383 ZNF420 ZNF793 ZNF568 ZNF571 ZNF585A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFP30 on UCSC Golden Path with GeneCards custom track

Promoters for ZFP30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109173 1985 3000 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263

Genomic Location for ZFP30 Gene

Chromosome:
19
Start:
37,613,749 bp from pter
End:
37,692,337 bp from pter
Size:
78,589 bases
Orientation:
Minus strand

Genomic View for ZFP30 Gene

Genes around ZFP30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP30 Gene

Proteins for ZFP30 Gene

  • Protein details for ZFP30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2G7-ZFP30_HUMAN
    Recommended name:
    Zinc finger protein 30 homolog
    Protein Accession:
    Q9Y2G7
    Secondary Accessions:
    • Q58EY8

    Protein attributes for ZFP30 Gene

    Size:
    519 amino acids
    Molecular mass:
    61558 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76805.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZFP30 Gene

Post-translational modifications for ZFP30 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFP30 Gene

Domains & Families for ZFP30 Gene

Gene Families for ZFP30 Gene

Protein Domains for ZFP30 Gene

Suggested Antigen Peptide Sequences for ZFP30 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2G7

UniProtKB/Swiss-Prot:

ZFP30_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP30: view

Function for ZFP30 Gene

Molecular function for ZFP30 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZFP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP30: view

Phenotypes for ZFP30 Gene

genes like me logo Genes that share phenotypes with ZFP30: view

Animal Model Products

CRISPR Products

miRNA for ZFP30 Gene

miRTarBase miRNAs that target ZFP30

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP30 Gene

Localization for ZFP30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP30 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP30 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZFP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP30: view

Pathways & Interactions for ZFP30 Gene

SuperPathways for ZFP30 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP30: view

Pathways by source for ZFP30 Gene

2 Reactome pathways for ZFP30 Gene

Gene Ontology (GO) - Biological Process for ZFP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZFP30: view

No data available for SIGNOR curated interactions for ZFP30 Gene

Drugs & Compounds for ZFP30 Gene

No Compound Related Data Available

Transcripts for ZFP30 Gene

mRNA/cDNA for ZFP30 Gene

(7) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP30 Gene

ZFP30 zinc finger protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP30 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP1: - - - - -
SP2: - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - - -
SP7: -

Relevant External Links for ZFP30 Gene

GeneLoc Exon Structure for
ZFP30
ECgene alternative splicing isoforms for
ZFP30

Expression for ZFP30 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP30 Gene

Protein differential expression in normal tissues from HIPED for ZFP30 Gene

This gene is overexpressed in Plasma (56.3) and Serum (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZFP30 Gene



Protein tissue co-expression partners for ZFP30 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFP30 Gene:

ZFP30

SOURCE GeneReport for Unigene cluster for ZFP30 Gene:

Hs.716719

Evidence on tissue expression from TISSUES for ZFP30 Gene

  • Nervous system(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with ZFP30: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP30 Gene

Orthologs for ZFP30 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP30 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia ZFP30 34 35
  • 91.1 (n)
cow
(Bos Taurus)
Mammalia ZFP30 34
  • 90.94 (n)
-- 35
  • 63 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp30 34 16 35
  • 79.84 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910007 34
  • 76.81 (n)
Species where no ortholog for ZFP30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP30 Gene

ENSEMBL:
Gene Tree for ZFP30 (if available)
TreeFam:
Gene Tree for ZFP30 (if available)

Paralogs for ZFP30 Gene

(467) SIMAP similar genes for ZFP30 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZFP30 Gene

genes like me logo Genes that share paralogs with ZFP30: view

Variants for ZFP30 Gene

Sequence variations from dbSNP and Humsavar for ZFP30 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs869312869 Likely pathogenic 37,635,811(-) ATGAA(C/T)GTAAA reference, missense
rs1000010153 -- 37,644,127(+) AAGAC(C/T)GGTAA intron-variant
rs1000047376 -- 37,638,619(+) TGATG(G/T)CATAT intron-variant
rs1000052870 -- 37,656,454(+) TTATC(C/T)GCATC upstream-variant-2KB
rs1000081452 -- 37,645,433(+) CTTTG(C/T)ATACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP30 Gene

Variant ID Type Subtype PubMed ID
nsv579468 CNV gain 21841781

Variation tolerance for ZFP30 Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP30 Gene

Human Gene Mutation Database (HGMD)
ZFP30
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP30 Gene

Disorders for ZFP30 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZFP30 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cerebral visual impairment
  • cortical visual impairment
- elite association - COSMIC cancer census association via MalaCards
Search ZFP30 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZFP30

Genetic Association Database (GAD)
ZFP30
Human Genome Epidemiology (HuGE) Navigator
ZFP30
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP30
genes like me logo Genes that share disorders with ZFP30: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZFP30 Gene

Publications for ZFP30 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Novel genetic causes for cerebral visual impairment. (PMID: 26350515) Bosch D.G. … de Vries B.B. (Eur. J. Hum. Genet. 2016) 3 64

Products for ZFP30 Gene

Sources for ZFP30 Gene

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