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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFP3 Gene

protein-coding   GIFtS: 43
GCID: GC17P004981

ZFP3 zinc finger protein

(Previous names: zinc finger protein homologous to Zfp-3 in mouse, zinc...)
  Search for ZFP3
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZFP3    

Aliases
for ZFP3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ZFP3 Zinc Finger Protein1 2     Zinc Finger Protein 3 Homolog (Mouse)1
ZNF7521 2 3     Zfp-33
Zinc Finger Protein Homologous To Zfp-3 In Mouse1 2     Zinc Finger Protein 3 Homolog2
Zinc Finger Protein 7522 3     Zinc Finger Protein-32
FLJ307261     Zfp-33

External Ids:    HGNC: 128611   Entrez Gene: 1249612   Ensembl: ENSG000001807877   OMIM: 1944805   UniProtKB: Q96NJ63   

Export aliases for ZFP3 gene to outside databases

Previous GC identifers: GC17U990112 GC17P004923 GC17P004872


Summaries
for ZFP3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ZFP3_HUMAN, Q96NJ6
Function: May be involved in transcriptional regulation




Genomic Views
for ZFP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFP3 gene promoter:
         NF-YA   Bach2   CUTL1   NF-YB   CBF-B   CBF-A   Chx10   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZFP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.2

ZFP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P004981:  view genomic region     (about GC identifiers)

Start:
 4,981,543 bp from pter      End:
 4,999,669 bp from pter
Size:
 18,127 bases      Orientation:
 plus strand

Proteins
for ZFP3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZFP3_HUMAN, Q96NJ6 (See protein sequence)
Recommended Name: Zinc finger protein 3 homolog  
Size: 502 amino acids; 57662 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: A5PLL4

Explore the universe of human proteins at neXtProt for ZFP3: NX_Q96NJ6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96NJ6

    • ZFP3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_694563.1  
    ENSEMBL proteins: 
     ENSP00000320347  

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    Uscn Proteins for ZFP3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--


    ZFP3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ZFP3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZFP3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96NJ6

    ProtoNet protein and cluster: Q96NJ6

    1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZFP3_HUMAN, Q96NJ6
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers


    Function
    for ZFP3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZFP3_HUMAN, Q96NJ6
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZFP3:
    zinc finger protein 3

    miRNA
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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZFP3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ZFP3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFP3

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0008150biological_process ND--


    ZFP3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZFP3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFP3
    Search CenterWatch for drugs/clinical trials and news about ZFP3 

    Transcripts
    for ZFP3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZFP3 gene: 
    NM_153018.2  

    Unigene Cluster for ZFP3:

    ZFP3 zinc finger protein
    Hs.48832  [show with all ESTs]
    Unigene Representative Sequence: NM_153018
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000318833(uc002gaq.3)

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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFP3 (see all 39):
    hsa-miR-142-5p hsa-miR-4291 hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-640 hsa-miR-106a hsa-miR-1260b
    SwitchGear 3'UTR luciferase reporter plasmid: ZFP3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFP3 (see all 7)
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP3

    Additional cDNA sequence: 

    AK125731.1 AK290549.1 BC142962.1 BX647638.1 

    2 DOTS entries:

    DT.308791  DT.95367273 

    24/40 AceView cDNA sequences (see all 40):

    AK055288 NM_153018 CR604942 AI382541 BG741878 BX447351 BX647638 BQ029732 
    N63611 AA490404 AW298729 AA018406 BQ941297 BQ016734 BX094152 AA845646 
    BX099730 BX415356 BP349288 CD515683 AA018070 AI039570 BX444317 AK125731 

    GeneLoc Exon Structure


    Expression
    for ZFP3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACAAAATTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZFP3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZFP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFP3

    SOURCE GeneReport for Unigene cluster: Hs.48832
        SABiosciences Custom PCR Arrays for ZFP3
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP3

    Orthologs
    for ZFP3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for ZFP3 (if available)
    TreeFam Gene Tree for ZFP3 (if available) 

    Paralogs
    for ZFP3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFP3 gene
    ZNF712  ZNF5862  ZNF5012  ZNF162  ZNF6232  ZFP22  ZNF3452  ZNF232  
    ZNF8522  ZNF5022  ZNF352  ZNF6602  ZKSCAN72  
    18/473 SIMAP similar genes for ZFP3 using alignment to 1 protein entry:     ZFP3_HUMAN(see all similar genes):
    HZF36    ZNF383    ZSCAN16    GLI4    ZNF271    zf30
    ZNF331    DKFZp666C237    ZNF565    ZNF619    ZNF660    HZF30
    ZNF146    ZNF480    ZNF501    ZNF586    ZNF696    ZNF724P

    ZFP3 for paralogs           About GeneDecksing



    Genomic Variants
    for ZFP3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/376 NCBI SNPs in ZFP3 are shown (see all 376)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1385961961,2
    		--4979769(+) GCTGGC/GATTAC 1 -- us2k10--------
    rs80767371,2
    		C,H,--4979778(+) ACAGGC/TGTGAG 1 -- us2k18Minor allele frequency- T:0.00NA WA CSA 17
    rs596078121,2
    		--4979873(+) TGTGAA/TCTGTC 1 -- us2k10--------
    rs613306261,2
    		--4979874(+) GTGATA/CTGTCT 1 -- us2k10--------
    rs1157596711,2
    		F,--4979910(+) TCACAT/CGCATG 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1161458801,2
    		F,--4979917(+) CATGAG/CCCACC 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1423399041,2
    		--4979928(+) ACGCCC/TGGCCG 1 -- us2k10--------
    rs769918661,2
    		C,F,--4979932(+) CCGGCC/TGGAAA 1 -- us2k13Minor allele frequency- T:0.05WA NA EA 358
    rs47907391,2
    		H--4980096(+) CTTTCT/CGCTAG 1 -- us2k1 trp34Minor allele frequency- C:0.00NS EA 418
    rs1439053781,2
    		--4980120(+) TACAAA/GCACAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZFP3 (4981543 - 4999669 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZFP3: --

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    Disorders / Diseases
    for ZFP3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZFP3 for disorders           About MalaCards

    ZFP3 for disorders           About GeneDecksing

    OMIM gene information: 194480    OMIM disorders: --


    Export disorders for ZFP3 gene to outside databases

    Publications
    for ZFP3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFP3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZFP3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for ZFP3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZFP3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 124961 HGNC: 12861 AceView: FLJ30726 Ensembl:ENSG00000180787 euGenes: HUgn124961
    ECgene: ZFP3 H-InvDB: ZFP3

    Other Databases showing ZFP3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZFP3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFP3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZFP3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZFP3 gene:
    Search GeneIP for patents involving ZFP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ZFP3 gene

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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
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    von Willebrand factor
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