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ZFP3 Gene

protein-coding   GIFtS: 46
GCID: GC17P004981

ZFP3 Zinc Finger Protein

(Previous names: zinc finger protein homologous to Zfp-3 in mouse, zinc finger...)
  Search for ZFP3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ZFP3 Zinc Finger Protein1 2     zfp-32
Zinc Finger Protein Homologous To Zfp-3 In Mouse1 2     Zinc Finger Protein 3 Homolog2
Zinc Finger Protein 7522 3     Zinc Finger Protein-32
ZNF7522 3     Zfp-33
Zinc Finger Protein 3 Homolog (Mouse)1     

External Ids:    HGNC: 128611   Entrez Gene: 1249612   Ensembl: ENSG000001807877   OMIM: 1944805   UniProtKB: Q96NJ63   

Export aliases for ZFP3 gene to outside databases

Previous GC identifers: GC17U990112 GC17P004923 GC17P004872


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZFP3 Gene:
ZFP3 (ZFP3 zinc finger protein) is a protein-coding gene. An important paralog of this gene is ZNF436.

UniProtKB/Swiss-Prot: ZFP3_HUMAN, Q96NJ6
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFP3 gene promoter:
         NF-YA   Bach2   CUTL1   NF-YB   CBF-B   CBF-A   Chx10   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFP3 promoter sequence
   Search Chromatin IP Primers for ZFP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.2

ZFP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P004981:  view genomic region     (about GC identifiers)

Start:
4,981,543 bp from pter      End:
4,999,669 bp from pter
Size:
18,127 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZFP3_HUMAN, Q96NJ6 (See protein sequence)
Recommended Name: Zinc finger protein 3 homolog  
Size: 502 amino acids; 57662 Da
Secondary accessions: A5PLL4

Explore the universe of human proteins at neXtProt for ZFP3: NX_Q96NJ6

Explore proteomics data for ZFP3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys251
  • Modification sites at PhosphoSitePlus

  • See ZFP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_694563.1  
    ENSEMBL proteins: 
     ENSP00000320347  

    ZFP3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96NJ6

    ProtoNet protein and cluster: Q96NJ6

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZFP3_HUMAN, Q96NJ6
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers


    Find genes that share domains with ZFP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFP3_HUMAN, Q96NJ6
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZFP3:
    zinc finger protein 3

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZFP3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZFP3
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    miRNA
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    miRTarBase miRNAs that target ZFP3:
    hsa-let-7e-5p (MIRT051663), hsa-mir-335-5p (MIRT017507)

    Block miRNA regulation of human, mouse, rat ZFP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFP3 (see all 39):
    hsa-miR-142-5p hsa-miR-4291 hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-640 hsa-miR-106a hsa-miR-1260b
    SwitchGear 3'UTR luciferase reporter plasmidZFP3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZFP3_HUMAN, Q96NJ6: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZFP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFP3
    Interactions:

        Search GeneGlobe Interaction Network for ZFP3

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--
    GO:0008150biological_process ND--

    Find genes that share ontologies with ZFP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFP3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZFP3 gene: 
    NM_153018.2  

    Unigene Cluster for ZFP3:

    ZFP3 zinc finger protein
    Hs.48832  [show with all ESTs]
    Unigene Representative Sequence: NM_153018
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000318833(uc002gaq.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat ZFP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFP3 (see all 39):
    hsa-miR-142-5p hsa-miR-4291 hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-640 hsa-miR-106a hsa-miR-1260b
    SwitchGear 3'UTR luciferase reporter plasmidZFP3 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZFP3

    Additional mRNA sequence: 

    AK125731.1 AK290549.1 BC142962.1 BX647638.1 

    2 DOTS entries:

    DT.308791  DT.95367273 

    Selected AceView cDNA sequences (see all 40):

    AK055288 AI382541 NM_153018 CR604942 AA018070 BX099730 AW298729 BG741878 
    AA018406 BP349288 BX094152 BX444317 AI039570 BQ016734 BX415356 BX647638 
    AA845646 AA490404 BQ941297 BQ029732 BX447351 AK125731 N63611 CD515683 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAAAATTT
    ZFP3 Expression
    About this image


    ZFP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Limb (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Skeletal Muscle (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
    ZFP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.48832
        Custom PCR Arrays for ZFP3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZFP3 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp31 , 5 zinc finger protein 31, 5 84.1(n)1
    87.12(a)1
      11 (43.21 cM)5
    1930431  NM_177565.31  NP_808233.11 
     707642095 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    49(a)
    many ↔ many
    GL344068.1(5323-6348)


    ENSEMBL Gene Tree for ZFP3 (if available)
    TreeFam Gene Tree for ZFP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZFP3 gene
    ZNF4362  ZNF1802  ZNF3222  ZNF712  ZNF5722  ZFP22  ZKSCAN72  ZNF6782  
    ZNF7742  ZNF102  ZFP372  ZSCAN22  ZNF3292  ZNF8522  ZNF5442  ZNF6062  
    ZNF5022  ZNF8352  
    Selected SIMAP similar genes for ZFP3 using alignment to 1 protein entry:     ZFP3_HUMAN(see all similar genes):
    HZF36    ZSCAN9    ZNF383    ZSCAN16    GLI4    ZNF271
    zf30    ZNF331    DKFZp666C237    ZNF565    ZNF619    ZNF660
    HZF30    ZNF146    ZNF480    ZNF501    ZNF586    ZNF696

    Find genes that share paralogs with ZFP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFP3 (see all 459)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1385961961,2
    C--4979769(+) GCTGGC/GATTAC 1 -- us2k10--------
    rs80767371,2
    C,H--4979778(+) acaggC/Tgtgag 1 -- us2k18Minor allele frequency- T:0.00NA WA CSA 17
    rs596078121,2
    --4979873(+) TGTGAA/TCTGTC 1 -- us2k10--------
    rs613306261,2
    --4979874(+) GTGATA/CTGTCT 1 -- us2k10--------
    rs1157596711,2
    C,F--4979910(+) TCACAT/CGCATG 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1161458801,2
    F--4979917(+) CATGAG/CCCACC 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1423399041,2
    C--4979928(+) ACGCCC/TGGCCG 1 -- us2k10--------
    rs769918661,2
    C,F--4979932(+) CCGGCC/TGGAAA 1 -- us2k13Minor allele frequency- T:0.05WA NA EA 358
    rs47907391,2
    H--4980096(+) CTTTCT/CGCTAG 1 -- us2k1 trp34Minor allele frequency- C:0.00NS EA 418
    rs1439053781,2
    --4980120(+) TACAAA/GCACAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZFP3 (4981543 - 4999669 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZFP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509648CNV Insertion20534489
    nsv907624CNV Loss21882294
    nsv907620CNV Loss21882294
    nsv907623CNV Loss21882294
    nsv827868CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFP3
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194480    OMIM disorders: --


    Find genes that share disorders with ZFP3           About GenesLikeMe


    Export disorders for ZFP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFP3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZFP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 124961 HGNC: 12861 AceView: FLJ30726 Ensembl:ENSG00000180787 euGenes: HUgn124961
    ECgene: ZFP3 H-InvDB: ZFP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZFP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFP3 gene:
    Search GeneIP for patents involving ZFP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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