ZFP28 Gene
protein-coding GIFtS: 48
GCID: GC19P057050
|
|
ZFP28 zinc finger protein(Previous name: zinc finger protein 28 homolog (mouse) )
| |
Aliases
for ZFP28 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ZFP28 Zinc Finger Protein1 2 | | Zfp-283 | | Mkr51 | | Zinc Finger Factor X62 | | KIAA14311 3 | | Zinc Finger Protein 28 Homolog2 | | Krueppel-Like Zinc Finger Factor X62 3 | | Zfp-283 | | Zinc Finger Protein 28 Homolog (Mouse)1 | | |
Export aliases for ZFP28 gene to outside databasesPrevious GC identifers: GC19U990300 GC19P057504 GC19P061592 GC19P061618 GC19P061609 GC19P061742 GC19P053360 |
Summaries
for ZFP28 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZFP28_HUMAN, Q8NHY6Function: May be involved in transcriptional regulation. May have a role in embryonic development
|
Genomic Views
for ZFP28 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZFP28 gene promoter:
TBP p53 Pax-5 AREB6 MEF-2A FOXO4 HFH-1 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZFP28
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP28 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43ZFP28 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P057050: view genomic region
(about GC identifiers)
Start:
|
57,050,317 bp from pter |
End:
|
57,068,170 bp from pter |
Size:
|
17,854 bases |
Orientation:
|
plus strand |
|
Proteins
for ZFP28 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZFP28_HUMAN, Q8NHY6 (See
protein sequence)Recommended Name: Zinc finger protein 28 homolog Size: 868 amino acids; 98705 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA92669.1; Type=Erroneous initiation;
6/13 PDB 3D structures from  and Proteopedia  for ZFP28 (see all 13):2EM2 (3D)
2EM3 (3D)
2EM4 (3D)
2EMJ (3D)
2EMK (3D)
2EML (3D)
Secondary accessions: A0JNV6 Q9BY30 Q9P2B6Explore the universe of human proteins at neXtProt for ZFP28: NX_Q8NHY6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NHY6
ZFP28 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065879.1
ENSEMBL proteins: ENSP00000301318 ENSP00000468603 ENSP00000465853 Reactome Protein details: Q8NHY6
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZFP28 for ontologies About GeneDecksing
ZFP28 Antibody Products:
Assay Products for ZFP28: |
Protein
Domains /
Families
for ZFP28 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZFP28 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NHY6ProtoNet protein and cluster: Q8NHY6 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZFP28_HUMAN, Q8NHY6Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 15 C2H2-type zinc fingersSimilarity: Contains 2 KRAB domains |
Function
for ZFP28 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZFP28_HUMAN, Q8NHY6Function: May be involved in transcriptional regulation. May have a role in embryonic development
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP28 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP28
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZFP28 (NM_020828) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZFP28 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP28 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP28 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZFP28 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZFP28 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZFP28
ZFP28 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFP28
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5 Interacting proteins for ZFP28 (Q8NHY62, 3 ENSP000003013184) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZFP28 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZFP28 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZFP28
Search CenterWatch for drugs/clinical trials and news about ZFP28
|
Transcripts
for ZFP28 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZFP28 gene: NM_020828.1 Unigene Cluster for ZFP28: ZFP28 zinc finger protein Hs.14794 [show with all ESTs]Unigene Representative Sequence: AF5070454 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000301318(uc002qni.3 uc002qnj.3) ENST00000591844 ENST00000589836
ENST00000588163
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP28 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP28
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZFP28 (NM_020828) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZFP28 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP28 |
Additional cDNA sequence: AB037852.1 AF226995.1 AF507045.1 AK289583.1 BC028416.2 BC099903.1 BC127002.1 BC127003.1 CR749659.1 6 DOTS entries: DT.432477 DT.86840808 DT.121496107 DT.100746680 DT.65288431 DT.75136176 24/51 AceView cDNA sequences (see all 51): AF507045 BM754007 AF226995 AI093747 BQ006498 AW590434 AA633931 AA831323 AL042491 BU618569 BM698777 BG574473 AB037852 NM_020828 BQ022635 AI057431 BF059299 BE503014 AA676900 AI334167 CR749659 BQ716029 AI243251 BX095153
GeneLoc Exon Structure
|
Expression
for ZFP28 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZFP28 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCCTGCAG
About this image
See ZFP28 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZFP28
SOURCE GeneReport for Unigene cluster: Hs.14794
SABiosciences Custom PCR Arrays for ZFP28
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFP28
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFP28 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFP28 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP28 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP28 |
Orthologs
for ZFP28 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZFP28 (if available)
TreeFam Gene Tree for ZFP28 (if available) |
Paralogs
for ZFP28 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZFP28 gene
- ZNF5702 ZNF2872 ZNF1812 ZNF4712 ZNF72 ZNF2502 ZNF3022 ZNF354C2
- ZNF8792 ZNF742 ZNF5832 ZFP902 ZNF1892 ZNF354A2 ZNF354B2 ZNF1352
- ZNF5682 ZNF342 ZNF5272 ZNF82 ZNF5692 ZNF4702
18/508 SIMAP similar genes for ZFP28 using alignment to 6 protein entries: ZFP28_HUMAN (see all proteins)
(see all similar genes):DKFZp686K03205 ZNF78L1 ZNF66 ZFS-4 kr-znf3 ZNF167
ZNF471 ZNF436 DKFZp434J0650 GLI4 HZF36 ZFP41
ZFS-1 ZFS-6 ZNF32 ZNF658B ZNF781 zf30
ZFP28 for paralogs About GeneDecksing
|
Genomic Variants
for ZFP28 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZFP28 (57050317 - 57068170 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZFP28: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFP28 |
|
Disorders
/ Diseases
for ZFP28 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZFP28 for disorders About GeneDecksing
1  disease for ZFP28: About MalaCardsmelanoma
Export disorders for ZFP28 gene to outside databases
|
Publications
for ZFP28 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZFP28 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZFP28) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development. (PubMed id 12127974)1, 2 Zhou L.... Wu X. (2002)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Zinc finger protein 28 as a novel melanoma-related mo lecule. (PubMed id 19329283)1 Yajima I....Kato M. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZFP28 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZFP28 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZFP28 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZFP28 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZFP28 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZFP28 gene:
Search GeneIP for patents involving ZFP28
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZFP28 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZFP28 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFP28 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFP28 | | | OriGene Protein Over-expression Lysate for ZFP28 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZFP28 | | OriGene 3'-UTR Clone for ZFP28 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP28 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP28 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZFP28 | | OriGene Custom Protein Services for ZFP28 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZFP28 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFP28 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP28 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFP28 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP28 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFP28 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZFP28 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZFP28 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP28 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZFP28 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP28 |
|
|
|
|
