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Aliases for ZFP28 Gene

Aliases for ZFP28 Gene

  • ZFP28 Zinc Finger Protein 2 3
  • Krueppel-Like Zinc Finger Factor X6 3 4
  • Zfp-28 3 4
  • Zinc Finger Protein 28 Homolog (Mouse) 2
  • Zinc Finger Protein 28 Homolog 3
  • Zinc Finger Factor X6 3
  • KIAA1431 4
  • Mkr5 3

External Ids for ZFP28 Gene

Summaries for ZFP28 Gene

GeneCards Summary for ZFP28 Gene

ZFP28 (ZFP28 Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression.

UniProtKB/Swiss-Prot for ZFP28 Gene

  • May be involved in transcriptional regulation. May have a role in embryonic development

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP28 Gene

Genomics for ZFP28 Gene

Genomic Location for ZFP28 Gene

Start:
56,538,948 bp from pter
End:
56,556,810 bp from pter
Size:
17,863 bases
Orientation:
Plus strand

Genomic View for ZFP28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFP28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP28 Gene

Regulatory Elements for ZFP28 Gene

Proteins for ZFP28 Gene

  • Protein details for ZFP28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHY6-ZFP28_HUMAN
    Recommended name:
    Zinc finger protein 28 homolog
    Protein Accession:
    Q8NHY6
    Secondary Accessions:
    • A0JNV6
    • K7ES88
    • Q8NHU8
    • Q9BY30
    • Q9P2B6

    Protein attributes for ZFP28 Gene

    Size:
    868 amino acids
    Molecular mass:
    98705 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92669.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZFP28 Gene

    Alternative splice isoforms for ZFP28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP28 Gene

Proteomics data for ZFP28 Gene at MOPED

Post-translational modifications for ZFP28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP28 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFP28 Gene

Domains for ZFP28 Gene

Gene Families for ZFP28 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZFP28 Gene

UniProtKB/Swiss-Prot:

ZFP28_HUMAN
Domain:
  • Contains 2 KRAB domains.:
    • Q8NHY6
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q8NHY6
Similarity:
  • Contains 15 C2H2-type zinc fingers.:
    • Q8NHY6
genes like me logo Genes that share domains with ZFP28: view

Function for ZFP28 Gene

Molecular function for ZFP28 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation. May have a role in embryonic development

Gene Ontology (GO) - Molecular Function for ZFP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP28: view

miRNA for ZFP28 Gene

miRTarBase miRNAs that target ZFP28

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFP28 Gene

Localization for ZFP28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP28 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP28 Gene COMPARTMENTS Subcellular localization image for ZFP28 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZFP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP28: view

Pathways for ZFP28 Gene

SuperPathways for ZFP28 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP28: view

Pathways by source for ZFP28 Gene

2 Reactome pathways for ZFP28 Gene

Gene Ontology (GO) - Biological Process for ZFP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZFP28: view

Transcripts for ZFP28 Gene

Unigene Clusters for ZFP28 Gene

ZFP28 zinc finger protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP28 Gene

No ASD Table

Relevant External Links for ZFP28 Gene

GeneLoc Exon Structure for
ZFP28
ECgene alternative splicing isoforms for
ZFP28

Expression for ZFP28 Gene

mRNA expression in normal human tissues for ZFP28 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFP28 Gene

SOURCE GeneReport for Unigene cluster for ZFP28 Gene Hs.14794

genes like me logo Genes that share expressions with ZFP28: view

Orthologs for ZFP28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFP28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP28 36
  • 99.46 (n)
  • 98.96 (a)
ZFP28 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100301148 36
  • 71.49 (n)
  • 73.73 (a)
ZFP28 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFP28 36
  • 87.14 (n)
  • 86.33 (a)
ZFP28 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp28 36
  • 79.29 (n)
  • 75.36 (a)
Zfp28 16
Zfp28 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFP28 37
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102548693 36
  • 78.47 (n)
  • 74.94 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 35 (a)
OneToMany
-- 37
  • 48 (a)
OneToMany
Species with no ortholog for ZFP28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP28 Gene

ENSEMBL:
Gene Tree for ZFP28 (if available)
TreeFam:
Gene Tree for ZFP28 (if available)

Paralogs for ZFP28 Gene

Selected SIMAP similar genes for ZFP28 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZFP28: view

No data available for Paralogs for ZFP28 Gene

Variants for ZFP28 Gene

Sequence variations from dbSNP and Humsavar for ZFP28 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs15693 -- 56,556,599(-) tgtta(A/T)aggat utr-variant-3-prime
rs145011 -- 56,553,820(+) GTGTT(C/T)GGAAG synonymous-codon, reference
rs379214 -- 56,550,704(+) AACTT(C/T)ACCCA intron-variant
rs399350 -- 56,552,271(+) GTATA(C/T)GTATT intron-variant, downstream-variant-500B
rs399970 -- 56,552,547(+) TGTAT(G/T)TATGC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZFP28 Gene

Variant ID Type Subtype PubMed ID
nsv912518 CNV Gain 21882294
nsv912519 CNV Loss 21882294
nsv524734 CNV Loss 19592680
nsv828651 CNV Gain 20364138

Relevant External Links for ZFP28 Gene

HapMap Linkage Disequilibrium report
ZFP28

Disorders for ZFP28 Gene

No disorders were found for ZFP28 Gene.

No data available for UniProtKB/Swiss-Prot for ZFP28 Gene

Publications for ZFP28 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development. (PMID: 12127974) Zhou L. … Wu X. (Biochem. Biophys. Res. Commun. 2002) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Zinc finger protein 28 as a novel melanoma-related molecule. (PMID: 19329283) Yajima I. … Kato M. (J. Dermatol. Sci. 2009) 3

Products for ZFP28 Gene

Sources for ZFP28 Gene

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