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ZFP2 Gene

protein-coding   GIFtS: 52
GCID: GC05P178322

ZFP2 Zinc Finger Protein

(Previous name: zinc finger protein 2 homolog (mouse))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ZFP2 Zinc Finger Protein1 2     Zinc Finger Protein 2 Homolog2
Zinc Finger Protein 7512 3     Zfp-23
ZNF7512 3     ZFP2965
Zinc Finger Protein 2 Homolog (Mouse)1     ZNF2965
zfp-22     ZNF3425

External Ids:    HGNC: 261381   Entrez Gene: 801082   Ensembl: ENSG000001989397   OMIM: 6132265   UniProtKB: Q6ZN573   

Export aliases for ZFP2 gene to outside databases

Previous GC identifers: GC05P178256 GC05P178257 GC05P173049


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZFP2 Gene:
ZFP2 (ZFP2 zinc finger protein) is a protein-coding gene. An important paralog of this gene is ZNF436.

UniProtKB/Swiss-Prot: ZFP2_HUMAN, Q6ZN57
Function: Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFP2 gene promoter:
         MEF-2A   SRY   Cart-1   POU6F1 (c2)   aMEF-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFP2 promoter sequence
   Search Chromatin IP Primers for ZFP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

ZFP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P178322:  view genomic region     (about GC identifiers)

Start:
178,322,895 bp from pter      End:
178,360,213 bp from pter
Size:
37,319 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZFP2_HUMAN, Q6ZN57 (See protein sequence)
Recommended Name: Zinc finger protein 2 homolog  
Size: 461 amino acids; 52740 Da
Sequence caution: Sequence=BAB15104.1; Type=Erroneous initiation;
Secondary accessions: A5PLN5 B7ZM23 Q9H6Z6

Explore the universe of human proteins at neXtProt for ZFP2: NX_Q6ZN57

Explore proteomics data for ZFP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys380
  • Modification sites at PhosphoSitePlus

  • See ZFP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_085116.2  
    ENSEMBL proteins: 
     ENSP00000354453   ENSP00000429095   ENSP00000431074   ENSP00000430980   ENSP00000430531  
     ENSP00000438114  
    Reactome Protein details: Q6ZN57

    ZFP2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZFP2

     
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    antibodies-online proteins for ZFP2 (2 products) 

     
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    antibodies-online antibodies for ZFP2 (5 products) 

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    antibodies-online kits for ZFP2 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6ZN57

    ProtoNet protein and cluster: Q6ZN57

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZFP2_HUMAN, Q6ZN57
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers


    Find genes that share domains with ZFP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFP2_HUMAN, Q6ZN57
    Function: Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance (By
    similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZFP2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZFP2:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZFP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZFP2:
    hsa-mir-335-5p (MIRT017994)

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    8 qRT-PCR Assays for microRNAs that regulate ZFP2:
    hsa-miR-130a* hsa-miR-23c hsa-miR-188-3p hsa-miR-199a-5p hsa-miR-23b hsa-miR-199b-5p hsa-miR-23a hsa-miR-145
    SwitchGear 3'UTR luciferase reporter plasmidZFP2 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZFP2_HUMAN, Q6ZN57: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZFP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZFP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZFP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZFP2
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFP2
    Interactions:

        Search GeneGlobe Interaction Network for ZFP2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for ZFP2 (Q6ZN572, 3 ENSP000003544534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN12Q052092, 3MINT-61773 I2D: score=3 
    CEBPEQ157443, ENSP000002065134I2D: score=1 STRING: ENSP00000206513
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZFP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZFP2 gene: 
    NM_030613.2  

    Unigene Cluster for ZFP2:

    ZFP2 zinc finger protein
    Hs.654533  [show with all ESTs]
    Unigene Representative Sequence: BC142989
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361362(uc003mjn.1 uc010jky.2 uc010jkx.1) ENST00000520660
    ENST00000520805 ENST00000520301 ENST00000523286 ENST00000503510
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate ZFP2:
    hsa-miR-130a* hsa-miR-23c hsa-miR-188-3p hsa-miR-199a-5p hsa-miR-23b hsa-miR-199b-5p hsa-miR-23a hsa-miR-145
    SwitchGear 3'UTR luciferase reporter plasmidZFP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZFP2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZFP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZFP2
      QuantiTect SYBR Green Assays in human, mouse, rat ZFP2
      QuantiFast Probe-based Assays in human, mouse, rat ZFP2

    Additional mRNA sequence: 

    AK025281.1 AK131367.1 BC132779.1 BC132781.1 BC142989.1 BC144213.1 BC144216.1 

    3 DOTS entries:

    DT.75198419  DT.411647  DT.120864386 

    7 AceView cDNA sequences:

    NM_030613 AK025281 BP376633 AK131367 AI908348 AI908349 BQ343739 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAAGATAA
    ZFP2 Expression
    About this image

    ZFP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654533
        Custom PCR Arrays for ZFP2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZFP2 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp21 , 5 zinc finger protein 21, 5 84.53(n)1
    85.84(a)1
      11 (30.94 cM)5
    226781  NM_001044698.11  NP_001038163.11 
     508987125 
    chicken
    (Gallus gallus)
    Aves ZFP31 zinc finger protein 3 homolog (mouse) 57.61(n)
    54.9(a)
      427922  XM_004937912.1  XP_004937969.1 


    ENSEMBL Gene Tree for ZFP2 (if available)
    TreeFam Gene Tree for ZFP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZFP2 gene
    ZNF4362  ZNF1802  ZNF3222  ZNF712  ZNF5722  ZKSCAN72  ZNF6782  ZNF7742  
    ZNF102  ZFP372  ZSCAN22  ZNF8522  ZNF3292  ZNF5442  ZFP32  ZNF6062  
    ZNF5022  ZNF8352  
    Selected SIMAP similar genes for ZFP2 using alignment to 3 protein entries:     ZFP2_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    DKFZp686M04222    ZFP41    ZFS-1    ZNF71    ZNF852
    HZF30    HZF36    HZF41    ZNF436    ZNF383    ZNF664
    ZNF    ZFS-5    ZNF146    ZNF24    ZNF323    ZNF485

    Find genes that share paralogs with ZFP2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZFP2
    PGOHUM00000247609


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFP2 (see all 982)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30316091,2
    C--173078738(-) tgtgt-/GTAT  
            
    atata
    1 -- int10--------
    rs728166081,2
    C,F--178320941(+) CCTTCC/ATACCT 1 -- us2k15Minor allele frequency- A:0.14NA WA EA 362
    rs1867938341,2
    --178321027(+) ACTTCA/GGCCTC 1 -- us2k10--------
    rs1431565511,2
    C--178321078(+) CCTGGA/CCTTTA 1 -- us2k10--------
    rs1511555331,2
    --178321111(+) TTTGGC/TATTAT 1 -- us2k10--------
    rs1425245191,2
    C--178321179(+) CCTTA-/TTTC  
            
    CTTGT
    1 -- us2k10--------
    rs1143026831,2
    C,F--178321280(+) GCGTCC/TTATGT 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs728166091,2
    C,F--178321502(+) GGGCAA/GCTTAG 1 -- us2k14Minor allele frequency- G:0.14NA EA 244
    rs761633021,2
    C,F--178321506(+) AACTTA/CGCAAG 1 -- us2k14Minor allele frequency- C:0.21NA CSA WA 242
    rs801870341,2
    C,F--178321614(+) TCTTAC/TGACCT 1 -- us2k14Minor allele frequency- T:0.21NA CSA WA 242

    HapMap Linkage Disequilibrium report for ZFP2 (178322895 - 178360213 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZFP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659273CNV Deletion23128226
    nsv821324CNV Deletion20802225
    esv2656988CNV Deletion23128226
    nsv5156CNV Loss18451855
    nsv819936CNV Gain19587683
    nsv883218CNV Gain21882294
    dgv987n67CNV Gain20364138
    esv27557CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613226    OMIM disorders: --


    Find genes that share disorders with ZFP2           About GenesLikeMe


    Export disorders for ZFP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFP2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZFP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    2. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    3. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (Genome Res. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80108 HGNC: 26138 AceView: FLJ21628 Ensembl:ENSG00000198939 euGenes: HUgn80108
    ECgene: ZFP2 H-InvDB: ZFP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZFP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFP2 gene:
    Search GeneIP for patents involving ZFP2

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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