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Aliases for ZFP2 Gene

Aliases for ZFP2 Gene

  • ZFP2 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 751 3 4
  • ZNF751 3 4
  • Zfp-2 3 4
  • Zinc Finger Protein 2 Homolog (Mouse) 2
  • Zinc Finger Protein 2 Homolog 3

External Ids for ZFP2 Gene

Previous GeneCards Identifiers for ZFP2 Gene

  • GC05P178256
  • GC05P178257
  • GC05P178322
  • GC05P173049

Summaries for ZFP2 Gene

GeneCards Summary for ZFP2 Gene

ZFP2 (ZFP2 Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF71.

UniProtKB/Swiss-Prot for ZFP2 Gene

  • Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.

Additional gene information for ZFP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP2 Gene

Genomics for ZFP2 Gene

Regulatory Elements for ZFP2 Gene

Enhancers for ZFP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H179619 1.7 Ensembl ENCODE dbSUPER 39.2 +726.4 726379 6 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZFP41 ZNF610 ZNF585B ZNF879 MRNIP HNRNPH1 MAML1 ZNF354C ZFP2 GRM6 LOC100996419 ENSG00000254035 CLK4
GH05H178203 1.4 ENCODE dbSUPER 20.1 -686.1 -686066 12 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000247679 LOC202181 ZNF354C FAM193B ZNF879 CLK4 RPL21P60 RMND5B ENSG00000254035 ZFP2
GH05H179761 1.5 Ensembl ENCODE dbSUPER 12.9 +867.1 867141 2 HDGF PKNOX1 ARID4B ZNF2 GLIS2 GATA2 ZNF143 FOS ATF7 RUNX3 MRNIP MAML1 ZNF879 LOC100996419 LTC4S MIR1229 SQSTM1 MGAT4B ZFP2 ZNF454
GH05H179803 1.3 ENCODE dbSUPER 12.9 +910.1 910059 5 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SP3 SP5 ZNF879 LOC100996419 ZFP2 ZNF454 GRM6 ENSG00000254035 ZNF354C MRNIP CNOT6 RN7SKP150
GH05H178151 1.1 ENCODE 13.5 -742.7 -742674 3 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 ZBTB7B YY1 FAM193B ENSG00000247679 ZNF879 ZFP2 ZNF354C ZNF354B LOC202181 RPL21P60 ENSG00000254035 ZNF454
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFP2 on UCSC Golden Path with GeneCards custom track

Promoters for ZFP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000191495 207 1399 TFAP4 MXI1 SAP130 SUZ12 ZNF76 RAD21 ETS1 GATAD1 POLR2A ZNF143

Genomic Location for ZFP2 Gene

Chromosome:
5
Start:
178,895,894 bp from pter
End:
178,933,212 bp from pter
Size:
37,319 bases
Orientation:
Plus strand

Genomic View for ZFP2 Gene

Genes around ZFP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP2 Gene

Proteins for ZFP2 Gene

  • Protein details for ZFP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN57-ZFP2_HUMAN
    Recommended name:
    Zinc finger protein 2 homolog
    Protein Accession:
    Q6ZN57
    Secondary Accessions:
    • A5PLN5
    • B7ZM23
    • Q9H6Z6

    Protein attributes for ZFP2 Gene

    Size:
    461 amino acids
    Molecular mass:
    52740 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15104.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZFP2 Gene

Post-translational modifications for ZFP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP2 Gene

No data available for DME Specific Peptides for ZFP2 Gene

Domains & Families for ZFP2 Gene

Gene Families for ZFP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZFP2 Gene

Suggested Antigen Peptide Sequences for ZFP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZN57

UniProtKB/Swiss-Prot:

ZFP2_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP2: view

Function for ZFP2 Gene

Molecular function for ZFP2 Gene

UniProtKB/Swiss-Prot Function:
Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.

Phenotypes From GWAS Catalog for ZFP2 Gene

Gene Ontology (GO) - Molecular Function for ZFP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP2: view
genes like me logo Genes that share phenotypes with ZFP2: view

Animal Model Products

CRISPR Products

miRNA for ZFP2 Gene

miRTarBase miRNAs that target ZFP2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZFP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP2 Gene

Localization for ZFP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZFP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZFP2 Gene

Pathways & Interactions for ZFP2 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP2: view

Pathways by source for ZFP2 Gene

2 Reactome pathways for ZFP2 Gene

Gene Ontology (GO) - Biological Process for ZFP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZFP2: view

No data available for SIGNOR curated interactions for ZFP2 Gene

Drugs & Compounds for ZFP2 Gene

No Compound Related Data Available

Transcripts for ZFP2 Gene

mRNA/cDNA for ZFP2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZFP2 Gene

ZFP2 zinc finger protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZFP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP2 Gene

No ASD Table

Relevant External Links for ZFP2 Gene

GeneLoc Exon Structure for
ZFP2
ECgene alternative splicing isoforms for
ZFP2

Expression for ZFP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZFP2 Gene:

ZFP2

SOURCE GeneReport for Unigene cluster for ZFP2 Gene:

Hs.654533

Evidence on tissue expression from TISSUES for ZFP2 Gene

  • Nervous system(4.2)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ZFP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP2 Gene

Orthologs for ZFP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP2 33 34
  • 99.28 (n)
cow
(Bos Taurus)
Mammalia ZFP2 33 34
  • 91.4 (n)
dog
(Canis familiaris)
Mammalia ZFP2 34 33
  • 90.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp2 33
  • 85.76 (n)
mouse
(Mus musculus)
Mammalia Zfp2 16 34 33
  • 84.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZFP3 33
  • 57.61 (n)
-- 34
  • 48 (a)
OneToMany
Species where no ortholog for ZFP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP2 Gene

ENSEMBL:
Gene Tree for ZFP2 (if available)
TreeFam:
Gene Tree for ZFP2 (if available)

Paralogs for ZFP2 Gene

(528) SIMAP similar genes for ZFP2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZFP2 Gene

genes like me logo Genes that share paralogs with ZFP2: view

Variants for ZFP2 Gene

Sequence variations from dbSNP and Humsavar for ZFP2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000199107 -- 178,896,028(+) AGGCC(A/C)CCGCA intron-variant
rs1000229326 -- 178,932,212(+) CAAAT(G/T)TAACA reference, missense
rs1000232035 -- 178,899,642(+) GAGTT(C/T)GCACA intron-variant
rs1000334680 -- 178,933,035(+) AACTG(A/G)ACAGC utr-variant-3-prime
rs1000382886 -- 178,920,310(+) TTTCT(A/G)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP2 Gene

Variant ID Type Subtype PubMed ID
dgv10203n54 CNV loss 21841781
dgv10204n54 CNV loss 21841781
dgv10205n54 CNV loss 21841781
dgv10206n54 CNV loss 21841781
dgv10207n54 CNV loss 21841781
dgv1682e212 CNV loss 25503493
dgv987n67 CNV gain 20364138
esv2656988 CNV deletion 23128226
esv2659273 CNV deletion 23128226
esv27557 CNV gain 19812545
esv3567091 CNV deletion 23714750
esv3607729 CNV loss 21293372
esv3607730 CNV loss 21293372
esv3890769 CNV gain 25118596
nsv1120062 OTHER inversion 24896259
nsv471919 CNV novel sequence insertion 20440878
nsv5156 CNV deletion 18451855
nsv600469 CNV loss 21841781
nsv819936 CNV gain 19587683
nsv821324 CNV deletion 20802225
nsv964988 CNV duplication 23825009

Variation tolerance for ZFP2 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP2 Gene

Disorders for ZFP2 Gene

Relevant External Links for ZFP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP2

No disorders were found for ZFP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP2 Gene

Publications for ZFP2 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  2. HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. (PMID: 25925205) Bhattacharya S … Ghosh MK (Cellular oncology (Dordrecht) 2015) 3 60
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland SL … Hayden MR (Human molecular genetics 2014) 3 60
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T … Hayashizaki Y (Cell 2010) 3 60

Products for ZFP2 Gene

Sources for ZFP2 Gene

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