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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFP14 Gene

protein-coding   GIFtS: 47
GCID: GC19M036829

ZFP14 Zinc Finger Protein

(Previous name: zinc finger protein 14 homolog (mouse))
  Search for ZFP14
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ZFP14 Zinc Finger Protein1 2     zfp-142
Zinc Finger Protein 5312 3     Zinc Finger Protein 14 Homolog2
ZNF5312 3     KIAA15593
Zinc Finger Protein 14 Homolog (Mouse)1     Zfp-143

External Ids:    HGNC: 293121   Entrez Gene: 576772   Ensembl: ENSG000001420657   UniProtKB: Q9HCL33   

Export aliases for ZFP14 gene to outside databases

Previous GC identifers: GC19M041522 GC19M036828 GC19M033295


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZFP14 Gene: 
ZFP14 (ZFP14 zinc finger protein) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF79.

UniProtKB/Swiss-Prot: ZFP14_HUMAN, Q9HCL3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFP14 gene promoter:
         STAT1   HSF2   HSF1short   HSF1 (long)   Cart-1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFP14 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFP14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.13

ZFP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFP14 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M036829:  view genomic region     (about GC identifiers)

Start:
36,825,355 bp from pter      End:
36,870,105 bp from pter
Size:
44,751 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZFP14_HUMAN, Q9HCL3 (See protein sequence)
Recommended Name: Zinc finger protein 14 homolog  
Size: 533 amino acids; 63463 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB13385.1; Type=Erroneous initiation;
Secondary accessions: A7MD23

Explore the universe of human proteins at neXtProt for ZFP14: NX_Q9HCL3

Explore proteomics data for ZFP14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCL3

  • ZFP14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFP14 Protein Expression
    REFSEQ proteins: NP_065968.1  
    ENSEMBL proteins: 
     ENSP00000270001   ENSP00000466416  
    Reactome Protein details: Q9HCL3
    Human Recombinant Protein Products for ZFP14: 
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    Cloud-Clone Corp. Proteins for ZFP14 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZFP14 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9HCL3

    ProtoNet protein and cluster: Q9HCL3

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZFP14_HUMAN, Q9HCL3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZFP14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFP14_HUMAN, Q9HCL3
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZFP14 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZFP14:
     Decreased cell number, increas 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZFP14 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZFP14
        Generic Transcription Pathway
    Gene Expression



    ZFP14 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFP14

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZFP14 (ENSP000002700014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZFP14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFP14

    Search CenterWatch for drugs/clinical trials and news about ZFP14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFP14 gene: 
    NM_020917.2  

    Unigene Cluster for ZFP14:

    ZFP14 zinc finger protein
    Hs.35524  [show with all ESTs]
    Unigene Representative Sequence: NM_020917
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000270001(uc010xtd.2 uc010eex.2) ENST00000589280
    miRNA
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    hsa-miR-3685 hsa-miR-181c hsa-miR-650 hsa-miR-606 hsa-miR-373* hsa-miR-542-3p hsa-miR-155* hsa-miR-3143
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFP14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP14

    Additional mRNA sequence: 

    AB046779.1 AK293103.1 BC144691.1 BC152446.1 

    5 DOTS entries:

    DT.96085384  DT.406829  DT.95132474  DT.40251951  DT.99967996 

    24/38 AceView cDNA sequences (see all 38):

    AA676432 AL138194 CB215147 AI057554 BX113677 BU156488 AI168186 AA448842 
    BE858793 AJ709242 AA301172 AI669825 BF939970 AA234585 BQ005583 BX499140 
    AA236477 BX485615 AL710044 AB046779 AL699477 AI742778 AI281219 AA975348 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZFP14    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:                          -         
    SP2:                          -         
    SP3:                                    


    ECgene alternative splicing isoforms for ZFP14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFP14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZFP14 Expression
    About this image


    See ZFP14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFP14

    SOURCE GeneReport for Unigene cluster: Hs.35524
        SABiosciences Custom PCR Arrays for ZFP14
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZFP14 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp141 , 5 zinc finger protein 141, 5 83.33(n)1
    87.75(a)1
      7 (17.26 cM)5
    2439061  NM_011748.21  NP_035878.11 
     300380535 


    ENSEMBL Gene Tree for ZFP14 (if available)
    TreeFam Gene Tree for ZFP14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFP14 gene
    ZNF792  ZNF5702  ZFP302  ZNF5292  ZNF7902  ZNF4832  ZNF3832  ZNF1812  
    ZNF2872  ZNF5822  ZNF4712  ZFP822  ZNF2502  ZNF8792  ZNF354C2  ZNF742  
    ZNF5832  ZNF4852  ZNF4542  ZFP902  ZNF3312  ZNF354A2  ZNF4612  ZNF3112  
    ZNF354B2  ZNF3452  ZNF5682  ZNF342  ZNF5652  
    18/475 SIMAP similar genes for ZFP14 using alignment to 3 protein entries:     ZFP14_HUMAN (see all proteins) (see all similar genes):
    ZNF780A    ZNF283    ZFP82    ZNF649    POM121C    ZNF607
    ZNF780B    ZNF232    ZNF519    ZNF573    ZNF546    ZFP90
    ZNF616    DKFZp686B16128    ZFP30    ZNF107    ZNF331    ZNF559

    ZFP14 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZFP14
    PGOHUM00000247679 PGOHUM00000235778


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/904 SNPs in ZFP14 are shown (see all 904)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480065741,2
    C--36824959(+) CCTCCA/GCCTCC 1 -- int10--------
    rs29675011,2
    C,F,A,H--36825029(+) agaaaC/Tggagt 1 -- int112Minor allele frequency- T:0.36NA WA CSA EA 377
    rs1421066131,2
    --36825034(+) TGGAGG/TTTTGC 1 -- int10--------
    rs1827165991,2
    --36825098(+) GGCCTC/TCCAAA 1 -- int10--------
    rs772094971,2
    F--36825160(+) TTGAAA/TCTTAT 1 -- int11Minor allele frequency- T:0.01EA 120
    rs1384420881,2
    C--36825226(+) TGGAAC/TAATGG 1 -- int10--------
    rs1440167631,2
    C--36825450(+) ACATAC/TCAAGG 1 -- ut310--------
    rs28571,2
    C,F,O,H--36825458(+) AGGATC/TGGGCT 1 -- ut3119Minor allele frequency- N:0.00MN NA EA NS 2206
    rs1506840881,2
    C--36825492(+) AAGCAC/TTAACC 1 -- ut310--------
    rs1870019911,2
    --36825562(+) ACTTAC/TGCCGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZFP14 (36825355 - 36870105 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for ZFP14 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv821399CNV Deletion20802225
    esv2421498CNV Deletion20811451
    esv2718503CNV Deletion23290073
    nsv436255CNV Deletion17901297
    dgv638e199CNV Deletion23128226
    nsv514898CNV Loss21397061
    nsv498900CNV Loss21111241
    nsv174CNV Loss15895083
    nsv2474CNV Loss18451855
    esv1010898CNV Gain20482838

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZFP14 for disorders           About MalaCards

    ZFP14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZFP14

    Export disorders for ZFP14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFP14 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZFP14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57677 HGNC: 29312 AceView: KIAA1559 Ensembl:ENSG00000142065 euGenes: HUgn57677
    ECgene: ZFP14 H-InvDB: ZFP14

    (According to HUGE)
    About This Section
    HUGE: KIAA1559

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFP14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFP14 gene:
    Search GeneIP for patents involving ZFP14

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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