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Aliases for ZFP14 Gene

Aliases for ZFP14 Gene

  • ZFP14 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 531 3 4
  • ZNF531 3 4
  • Zinc Finger Protein 14 Homolog (Mouse) 2
  • Zinc Finger Protein 14 Homolog 3
  • KIAA1559 4
  • Zfp-14 4

External Ids for ZFP14 Gene

Previous GeneCards Identifiers for ZFP14 Gene

  • GC19M041522
  • GC19M036828
  • GC19M033295
  • GC19M036829
  • GC19M037068
  • GC19M036387
  • GC19M036697
  • GC19M036879
  • GC19M036900
  • GC19M037413

Summaries for ZFP14 Gene

GeneCards Summary for ZFP14 Gene

ZFP14 (ZFP14 Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZFP82.

UniProtKB/Swiss-Prot for ZFP14 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP14 Gene

Genomics for ZFP14 Gene

Regulatory Elements for ZFP14 Gene

Enhancers for ZFP14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G035820 1.1 ENCODE 55.7 +559.0 559030 0.2 FOXA2 ARID4B FEZF1 ZNF2 ZNF302 ZNF416 ZNF143 ZNF263 SP3 MCM3 ZNF529 ZNF461 ZNF790-AS1 LINC01534 ZNF567 ZFP82 ZFP14 ZNF260 ZNF529-AS1 LINC00665
GH19G035897 1.8 FANTOM5 ENCODE dbSUPER 31.3 +475.1 475146 13.0 CREB3L1 FEZF1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 ZFP41 TMEM147-AS1 ZNF345 ZNF850 ZNF567 ZNF529 RBM42 KMT2B ZFP14 ZNF260 ZNF792
GH19G035946 1.6 FANTOM5 Ensembl ENCODE 34.4 +431.8 431811 0.8 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF416 ZNF143 ZNF548 ZNF567 ZNF345 TMEM147-AS1 ZNF850 ZNF529 ZNF790-AS1 HAUS5 ZNF461 ZNF790 LINC00665
GH19G035445 1.9 FANTOM5 Ensembl ENCODE dbSUPER 28.5 +931.2 931164 4.7 PKNOX1 ATF1 DMAP1 YY1 ZNF121 GLIS2 YY2 REST ZNF592 GLIS1 TMEM147-AS1 ZFP82 ZFP14 HAUS5 LINC00665 ZNF146 ZNF565 FFAR2 WTIP NFKBID
GH19G036526 1.4 FANTOM5 ENCODE 38 -149.0 -149004 2.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF302 ZNF260 ZNF383 ZNF345 ZNF585B ZNF567 ZNF850 ZNF529 ZNF790 ZNF793 TMEM147-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFP14 on UCSC Golden Path with GeneCards custom track

Promoters for ZFP14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109133 203 1600 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 CBX5 ZNF207

Genomic Location for ZFP14 Gene

Chromosome:
19
Start:
36,334,453 bp from pter
End:
36,379,203 bp from pter
Size:
44,751 bases
Orientation:
Minus strand

Genomic View for ZFP14 Gene

Genes around ZFP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP14 Gene

Proteins for ZFP14 Gene

  • Protein details for ZFP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCL3-ZFP14_HUMAN
    Recommended name:
    Zinc finger protein 14 homolog
    Protein Accession:
    Q9HCL3
    Secondary Accessions:
    • A7MD23

    Protein attributes for ZFP14 Gene

    Size:
    533 amino acids
    Molecular mass:
    63463 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13385.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZFP14 Gene

Post-translational modifications for ZFP14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFP14 Gene

No data available for DME Specific Peptides for ZFP14 Gene

Domains & Families for ZFP14 Gene

Gene Families for ZFP14 Gene

Suggested Antigen Peptide Sequences for ZFP14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCL3

UniProtKB/Swiss-Prot:

ZFP14_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZFP14: view

Function for ZFP14 Gene

Molecular function for ZFP14 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZFP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFP14: view
genes like me logo Genes that share phenotypes with ZFP14: view

Animal Models for ZFP14 Gene

MGI Knock Outs for ZFP14:

Animal Model Products

CRISPR Products

miRNA for ZFP14 Gene

miRTarBase miRNAs that target ZFP14

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZFP14 Gene

Localization for ZFP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFP14 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZFP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFP14: view

Pathways & Interactions for ZFP14 Gene

SuperPathways for ZFP14 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP14: view

Pathways by source for ZFP14 Gene

2 Reactome pathways for ZFP14 Gene

Gene Ontology (GO) - Biological Process for ZFP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZFP14: view

No data available for SIGNOR curated interactions for ZFP14 Gene

Drugs & Compounds for ZFP14 Gene

No Compound Related Data Available

Transcripts for ZFP14 Gene

mRNA/cDNA for ZFP14 Gene

Unigene Clusters for ZFP14 Gene

ZFP14 zinc finger protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -
SP3:

Relevant External Links for ZFP14 Gene

GeneLoc Exon Structure for
ZFP14
ECgene alternative splicing isoforms for
ZFP14

Expression for ZFP14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFP14 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFP14 Gene:

ZFP14

SOURCE GeneReport for Unigene cluster for ZFP14 Gene:

Hs.35524

Evidence on tissue expression from TISSUES for ZFP14 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZFP14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFP14 Gene

Orthologs for ZFP14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZFP14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP14 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia ZFP14 35
  • 96 (a)
OneToOne
LOC100683244 34
  • 88.45 (n)
cow
(Bos Taurus)
Mammalia ZFP14 34
  • 92.12 (n)
ZNF404 35
  • 54 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp14 35 16 34
  • 83.33 (n)
OneToOne
Species where no ortholog for ZFP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZFP14 Gene

ENSEMBL:
Gene Tree for ZFP14 (if available)
TreeFam:
Gene Tree for ZFP14 (if available)

Paralogs for ZFP14 Gene

(478) SIMAP similar genes for ZFP14 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZFP14 Gene

genes like me logo Genes that share paralogs with ZFP14: view

Variants for ZFP14 Gene

Sequence variations from dbSNP and Humsavar for ZFP14 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000003085 -- 36,357,783(+) TGTCA(C/T)CCAGG intron-variant
rs1000111521 -- 36,334,229(+) CCACC(A/G)TGCCT downstream-variant-500B
rs1000119981 -- 36,375,675(+) GCCTC(A/G)GCCTC intron-variant
rs1000227997 -- 36,334,003(+) GCATG(A/T)TCACA downstream-variant-500B
rs1000285303 -- 36,363,484(+) GCCAC(C/G/T)GCGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP14 Gene

Variant ID Type Subtype PubMed ID
dgv1041e212 CNV loss 25503493
dgv1777n106 CNV deletion 24896259
dgv3523n100 CNV loss 25217958
dgv3524n100 CNV loss 25217958
dgv638e199 CNV deletion 23128226
dgv6424n54 CNV loss 21841781
dgv6425n54 CNV loss 21841781
dgv6426n54 CNV loss 21841781
dgv6427n54 CNV gain 21841781
dgv6428n54 CNV loss 21841781
dgv6429n54 CNV loss 21841781
dgv6430n54 CNV loss 21841781
dgv6431n54 CNV loss 21841781
dgv83n73 CNV deletion 24416366
esv1010898 CNV gain 20482838
esv2421498 CNV deletion 20811451
esv26179 CNV gain 19812545
esv2718503 CNV deletion 23290073
esv2760511 CNV loss 21179565
esv2763143 CNV loss 21179565
esv3556338 CNV deletion 23714750
esv3644253 CNV gain 21293372
esv3644255 CNV loss 21293372
nsv1066190 CNV loss 25217958
nsv174 CNV deletion 15895083
nsv2474 CNV deletion 18451855
nsv436255 CNV deletion 17901297
nsv498900 CNV loss 21111241
nsv514898 CNV loss 21397061
nsv579431 CNV loss 21841781
nsv579432 CNV loss 21841781
nsv579440 CNV loss 21841781
nsv579459 CNV loss 21841781
nsv579460 CNV loss 21841781
nsv821399 CNV deletion 20802225
nsv833816 CNV gain 17160897
nsv9716 CNV gain+loss 18304495

Variation tolerance for ZFP14 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP14 Gene

Human Gene Mutation Database (HGMD)
ZFP14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP14 Gene

Disorders for ZFP14 Gene

Relevant External Links for ZFP14

Genetic Association Database (GAD)
ZFP14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP14

No disorders were found for ZFP14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP14 Gene

Publications for ZFP14 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZFP14 Gene

Sources for ZFP14 Gene

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