ZFP1 Gene
protein-coding GIFtS: 49
GCID: GC16P075182
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ZFP1 zinc finger protein(Previous names: zinc finger protein 1 homolog (mouse), zinc finger protein...)
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Aliases
for ZFP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ZFP1 Zinc Finger Protein1 2 | | Zinc Finger Protein 1 Homolog (Mouse)1 | | ZNF4751 2 3 | | Zfp-13 | | Zinc Finger Protein 4752 3 | | Zinc Finger Protein 1 Homolog2 | | FLJ342431 | | Zfp-13 | | Zinc Finger Protein 11 | | |
Export aliases for ZFP1 gene to outside databasesPrevious GC identifers: GC16P074921 GC16P074961 GC16P073739 GC16P060933 |
Summaries
for ZFP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZFP1_HUMAN, Q6P2D0Function: May be involved in transcriptional regulation
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Genomic Views
for ZFP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZFP1 gene promoter:
Nkx5-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZFP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q23.1 Ensembl cytogenetic band: 16q23.1 HGNC cytogenetic band: 16q22.3ZFP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P075182: view genomic region
(about GC identifiers)
Start:
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75,182,390 bp from pter |
End:
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75,206,134 bp from pter |
Size:
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23,745 bases |
Orientation:
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plus strand |
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Proteins
for ZFP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZFP1_HUMAN, Q6P2D0 (See
protein sequence)Recommended Name: Zinc finger protein 1 homolog Size: 407 amino acids; 47516 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH33774.1; Type=Erroneous initiation;
Secondary accessions: A8K5Q7 B4DKG9 Q8N188 Q8N9F9Alternative splicing: 2 isoforms: Q6P2D0-1 Q6P2D0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZFP1: NX_Q6P2D0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P2D0
ZFP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_710155.2
ENSEMBL proteins: ENSP00000457044 ENSP00000454286 ENSP00000457941 ENSP00000333192 ENSP00000377080 ENSP00000455627 Reactome Protein details: Q6P2D0
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZFP1 for ontologies About GeneDecksing
ZFP1 Antibody Products:
Assay Products for ZFP1: |
Protein
Domains /
Families
for ZFP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZFP1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6P2D0ProtoNet protein and cluster: Q6P2D0 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZFP1_HUMAN, Q6P2D0Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 8 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZFP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZFP1_HUMAN, Q6P2D0Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZFP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZFP1 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZFP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZFP1
ZFP1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFP1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for ZFP1 (ENSP000003331924) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZFP1 for ontologies About GeneDecksing
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Drugs & Compounds
for ZFP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZFP1
Search CenterWatch for drugs/clinical trials and news about ZFP1
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Transcripts
for ZFP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZFP1 gene: NM_153688.2 Unigene Cluster for ZFP1: ZFP1 zinc finger protein Hs.388813 [show with all ESTs]Unigene Representative Sequence: AL1330389 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000570010 ENST00000566105 ENST00000563356 ENST00000568079 ENST00000564989
ENST00000464850 ENST00000332307 ENST00000393430(uc002fdo.3 uc002fdp.3 uc010cgs.3 uc010cgt.3 uc002fdq.3)
ENST00000567481
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZFP1 (NM_003409) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZFP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP1 |
Additional cDNA sequence: AK091562.1 AK094761.1 AK291372.1 AK296560.1 AK308134.1 AL133038.1 BC033774.1 BC064604.1 BC113863.1 BC114471.1 BC127184.1 BC127185.1 BX647144.1 5 DOTS entries: DT.120727862 DT.97808664 DT.75102106 DT.100812110 DT.120727874 24/67 AceView cDNA sequences (see all 67): AX747061 BC064604 CB162244 BX956801 BQ050817 CB118149 AA962375 AK091562 AI091746 AI208547 BM921040 BM460515 BI870117 AA873473 AL038510 CA394086 AI418966 AL133038 W21059 BE895689 AW161880 BQ574509 BG393302 BU156781
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ZFP1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b |
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| SP1: | | | - | | | | | | |
| SP2: | | | | | | | | |
ECgene alternative splicing isoforms for ZFP1
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Expression
for ZFP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZFP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGAATGGT
About this image
See ZFP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZFP1
SOURCE GeneReport for Unigene cluster: Hs.388813
SABiosciences Custom PCR Arrays for ZFP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP1 |
Orthologs
for ZFP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZFP1 gene from 1/9 species (see all 9) About this table
ENSEMBL Gene Tree for ZFP1 (if available)
TreeFam Gene Tree for ZFP1 (if available) |
Paralogs
for ZFP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZFP1 gene
18/536 SIMAP similar genes for ZFP1 using alignment to 5 protein entries: ZFP1_HUMAN (see all proteins)
(see all similar genes):kr-znf3 DKFZp313M0722 ZNF323 ZNF300P1 ZNF721 POM121C
ZNF720 ZNF397 ZNF81 PMS2P3 ZNF32 ZNF78L1
ZNF268 ZNF283 GLI4 DKFZp666C237 KRBOX4 ZFS-5
ZFP1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for ZFP1
PGOHUM00000262393 PGOHUM00000250583 PGOHUM00000262825
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Genomic Variants
for ZFP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZFP1 (75182390 - 75206134 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZFP1
1 CNV: 4967
1 Inversion: 37183 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFP1 |
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Disorders
/ Diseases
for ZFP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZFP1 for disorders About GeneDecksing
1  disease for ZFP1: About MalaCardscholesterol
Human Genome Epidemiology (HuGE) Navigator: ZFP1 (1 document)
Export disorders for ZFP1 gene to outside databases
|
Publications
for ZFP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZFP1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ZFP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene. (PubMed id 2574853)1, 3 Chowdhury K....Gruss P. (1989)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Recognition and Suppression of Transfected Plasmids by Protein ZNF511-PRAP1, a Potential Molecular Barrier to Transgene Expression. (PubMed id 21540836)1 Qiu G.H.... Hooi S.C. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)1 Dastani Z....Genest J. (2010)
- Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
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External Searches for ZFP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZFP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZFP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZFP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZFP1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZFP1 gene:
Search GeneIP for patents involving ZFP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZFP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZFP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFP1 | | | OriGene Protein Over-expression Lysate for ZFP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for ZFP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZFP1 | | OriGene Custom Protein Services for ZFP1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZFP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFP1 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZFP1 |
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 | | | ZFP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFP1 |
|  |  |  | | | | ThermoFisher Antibodies for ZFP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFP1 |
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