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Aliases for ZFP1 Gene

Aliases for ZFP1 Gene

  • ZFP1 Zinc Finger Protein 2 3 5
  • Zinc Finger Protein 475 3 4
  • ZNF475 3 4
  • Zinc Finger Protein 1 Homolog (Mouse) 2
  • Zinc Finger Protein 1 2
  • Zfp-1 4

External Ids for ZFP1 Gene

Previous GeneCards Identifiers for ZFP1 Gene

  • GC16P074921
  • GC16P074961
  • GC16P073739
  • GC16P075182
  • GC16P060933

Summaries for ZFP1 Gene

Entrez Gene Summary for ZFP1 Gene

  • This gene belongs to the zinc finger protein family. Some members of this family bind to DNA by zinc-mediated secondary structures called zinc fingers, and are involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for ZFP1 Gene

ZFP1 (ZFP1 Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF248.

UniProtKB/Swiss-Prot for ZFP1 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFP1 Gene

Genomics for ZFP1 Gene

Regulatory Elements for ZFP1 Gene

Transcription factor binding sites by QIAGEN in the ZFP1 gene promoter:

Genomic Location for ZFP1 Gene

Chromosome:
16
Start:
75,132,509 bp from pter
End:
75,172,236 bp from pter
Size:
39,728 bases
Orientation:
Plus strand

Genomic View for ZFP1 Gene

Genes around ZFP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFP1 Gene

Proteins for ZFP1 Gene

  • Protein details for ZFP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2D0-ZFP1_HUMAN
    Recommended name:
    Zinc finger protein 1 homolog
    Protein Accession:
    Q6P2D0
    Secondary Accessions:
    • A8K5Q7
    • B4DKG9
    • Q8N188
    • Q8N9F9

    Protein attributes for ZFP1 Gene

    Size:
    407 amino acids
    Molecular mass:
    47516 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH33774.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFP1 Gene

Proteomics data for ZFP1 Gene at MOPED

Post-translational modifications for ZFP1 Gene

  • Ubiquitination at Lys 74, Lys 88, Lys 105, Lys 111, Lys 114, Lys 129, Lys 145, and Lys 196
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZFP1 Gene

Domains & Families for ZFP1 Gene

Gene Families for ZFP1 Gene

Protein Domains for ZFP1 Gene

Suggested Antigen Peptide Sequences for ZFP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P2D0

UniProtKB/Swiss-Prot:

ZFP1_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFP1: view

Function for ZFP1 Gene

Molecular function for ZFP1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZFP1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFP1 Gene

Localization for ZFP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFP1 Gene COMPARTMENTS Subcellular localization image for ZFP1 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZFP1 Gene

Pathways & Interactions for ZFP1 Gene

SuperPathways for ZFP1 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZFP1: view

Pathways by source for ZFP1 Gene

2 Reactome pathways for ZFP1 Gene

Interacting Proteins for ZFP1 Gene

Gene Ontology (GO) - Biological Process for ZFP1 Gene

None

No data available for SIGNOR curated interactions for ZFP1 Gene

Drugs & Compounds for ZFP1 Gene

No Compound Related Data Available

Transcripts for ZFP1 Gene

Unigene Clusters for ZFP1 Gene

ZFP1 zinc finger protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFP1 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for ZFP1 Gene

GeneLoc Exon Structure for
ZFP1
ECgene alternative splicing isoforms for
ZFP1

Expression for ZFP1 Gene

mRNA expression in normal human tissues for ZFP1 Gene

Protein differential expression in normal tissues from HIPED for ZFP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (56.0) and Islet of Langerhans (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFP1 Gene



SOURCE GeneReport for Unigene cluster for ZFP1 Gene Hs.388813

genes like me logo Genes that share expression patterns with ZFP1: view

Protein tissue co-expression partners for ZFP1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFP1 Gene

Orthologs for ZFP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFP1 35
  • 99.67 (n)
  • 100 (a)
ZFP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFP1 36
  • 89 (a)
OneToOne
ZFP1 35
  • 89.84 (n)
  • 92.14 (a)
dog
(Canis familiaris)
Mammalia ZFP1 35
  • 90.86 (n)
  • 93.27 (a)
ZFP1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp1 16
Zfp1 36
  • 87 (a)
OneToOne
Zfp1 35
  • 82.88 (n)
  • 86.6 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfp1 35
  • 82.05 (n)
  • 86.35 (a)
zebrafish
(Danio rerio)
Actinopterygii BX649328.1 36
  • 36 (a)
ManyToMany
CABZ01015530.1 36
  • 39 (a)
ManyToMany
CABZ01071909.3 36
  • 37 (a)
ManyToMany
CABZ01081748.1 36
  • 40 (a)
ManyToMany
CABZ01081749.1 36
  • 35 (a)
ManyToMany
CR788316.4 36
  • 38 (a)
ManyToMany
si:ch211-161m3.4 36
  • 34 (a)
ManyToMany
si:ch73-266f23.3 36
  • 37 (a)
ManyToMany
si:ch73-57f22.2 36
  • 29 (a)
ManyToMany
si:dkey-240n22.8 36
  • 34 (a)
ManyToMany
si:dkey-262g12.7 36
  • 41 (a)
ManyToMany
si:dkey-77f5.14 36
  • 32 (a)
ManyToMany
si:dkey-77f5.15 36
  • 25 (a)
ManyToMany
si:dkey-77p23.2 36
  • 38 (a)
ManyToMany
zgc:175008 36
  • 39 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Kr-h1 36
  • 13 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M03D4.4 36
  • 16 (a)
OneToMany
Species with no ortholog for ZFP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZFP1 Gene

ENSEMBL:
Gene Tree for ZFP1 (if available)
TreeFam:
Gene Tree for ZFP1 (if available)

Paralogs for ZFP1 Gene

(552) SIMAP similar genes for ZFP1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZFP1 Gene

genes like me logo Genes that share paralogs with ZFP1: view

Variants for ZFP1 Gene

Sequence variations from dbSNP and Humsavar for ZFP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1114513 -- 75,158,338(-) AAAAA(A/G)AAATA intron-variant
rs1579332 -- 75,138,559(-) ataag(C/G)tcaca intron-variant
rs2870464 -- 75,165,203(+) tttta(C/G)cagag intron-variant
rs2870465 -- 75,165,228(+) gaaaa(A/G)gaaaa intron-variant
rs3851732 -- 75,165,619(+) cgaac(A/G)cctgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFP1 Gene

Variant ID Type Subtype PubMed ID
nsv833282 CNV Gain+Loss 17160897
esv2714705 CNV Deletion 23290073
esv2714706 CNV Deletion 23290073
nsv7286 OTHER Inversion 18451855

Variation tolerance for ZFP1 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFP1 Gene

HapMap Linkage Disequilibrium report
ZFP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFP1 Gene

Disorders for ZFP1 Gene

Relevant External Links for ZFP1

Genetic Association Database (GAD)
ZFP1
Human Genome Epidemiology (HuGE) Navigator
ZFP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFP1

No disorders were found for ZFP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFP1 Gene

Publications for ZFP1 Gene

  1. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 48 67
  2. Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene. (PMID: 2574853) Chowdhury K. … Gruss P. (Nucleic Acids Res. 1989) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin B.M. … Amundadottir L.T. (Nat. Genet. 2014) 3
  5. Recognition and Suppression of Transfected Plasmids by Protein ZNF511-PRAP1, a Potential Molecular Barrier to Transgene Expression. (PMID: 21540836) Qiu G.H. … Hooi S.C. (Mol. Ther. 2011) 3

Products for ZFP1 Gene

Sources for ZFP1 Gene

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