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Aliases for ZFHX4 Gene

Aliases for ZFHX4 Gene

  • Zinc Finger Homeobox 4 2 3
  • ZFH4 3 6
  • Zinc-Finger Homeodomain Protein 4 3
  • Zinc Finger Homeodomain Protein 4 4
  • Zinc Finger Homeobox Protein 4 3
  • Zinc Finger Homeodomain 4 2
  • ZFH-4 4
  • ZHF4 3

External Ids for ZFHX4 Gene

Previous GeneCards Identifiers for ZFHX4 Gene

  • GC08P077778
  • GC08P077593
  • GC08P073079

Summaries for ZFHX4 Gene

GeneCards Summary for ZFHX4 Gene

ZFHX4 (Zinc Finger Homeobox 4) is a Protein Coding gene. Diseases associated with ZFHX4 include ptosis, congenital and ptosis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ZFHX3.

UniProtKB/Swiss-Prot for ZFHX4 Gene

  • May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFHX4 Gene

Genomics for ZFHX4 Gene

Regulatory Elements for ZFHX4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZFHX4 Gene

76,681,219 bp from pter
76,867,285 bp from pter
186,067 bases
Plus strand

Genomic View for ZFHX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFHX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFHX4 Gene

Proteins for ZFHX4 Gene

  • Protein details for ZFHX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger homeobox protein 4
    Protein Accession:
    Secondary Accessions:
    • G3V138
    • Q18PS0
    • Q6ZN20

    Protein attributes for ZFHX4 Gene

    3567 amino acids
    Molecular mass:
    393730 Da
    Quaternary structure:
    No Data Available
    • Sequence=AK131408; Type=Frameshift; Positions=338; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFHX4 Gene


neXtProt entry for ZFHX4 Gene

Proteomics data for ZFHX4 Gene at MOPED

Post-translational modifications for ZFHX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFHX4 Gene

Domains for ZFHX4 Gene

Gene Families for ZFHX4 Gene

  • ZFHX :Homeoboxes / ZF class

Suggested Antigen Peptide Sequences for ZFHX4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q86UP3
  • Contains 4 homeobox DNA-binding domains.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 20 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFHX4: view

Function for ZFHX4 Gene

Molecular function for ZFHX4 Gene

UniProtKB/Swiss-Prot Function: May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZFHX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0003779 actin binding --
GO:0008270 zinc ion binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ZFHX4: view

Phenotypes for ZFHX4 Gene

GenomeRNAi human phenotypes for ZFHX4:
genes like me logo Genes that share phenotypes with ZFHX4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFHX4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFHX4 Gene

Localization for ZFHX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFHX4 Gene

Subcellular locations from

Jensen Localization Image for ZFHX4 Gene COMPARTMENTS Subcellular localization image for ZFHX4 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZFHX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFHX4: view

Pathways for ZFHX4 Gene

SuperPathways for ZFHX4 Gene

No Data Available

Interacting Proteins for ZFHX4 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000430497 for ZFHX4 Gene via STRING

Gene Ontology (GO) - Biological Process for ZFHX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007010 cytoskeleton organization --
genes like me logo Genes that share ontologies with ZFHX4: view

No data available for Pathways by source for ZFHX4 Gene

Transcripts for ZFHX4 Gene

Unigene Clusters for ZFHX4 Gene

Zinc finger homeobox 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFHX4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZFHX4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFHX4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - - - - -
SP2: - -
SP5: -

Relevant External Links for ZFHX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFHX4 Gene

mRNA expression in normal human tissues for ZFHX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFHX4 Gene

SOURCE GeneReport for Unigene cluster for ZFHX4 Gene Hs.458973

mRNA Expression by UniProt/SwissProt for ZFHX4 Gene

Tissue specificity: Expressed in brain, skeletal muscle and liver. Very low expression in stomach
genes like me logo Genes that share expressions with ZFHX4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZFHX4 Gene

Orthologs for ZFHX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFHX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFHX4 35
  • 99.43 (n)
  • 99.51 (a)
ZFHX4 36
  • 99 (a)
(Bos Taurus)
Mammalia ZFHX4 35
  • 89.76 (n)
  • 94.16 (a)
ZFHX4 36
  • 94 (a)
(Canis familiaris)
Mammalia ZFHX4 35
  • 92.04 (n)
  • 95.85 (a)
ZFHX4 36
  • 95 (a)
(Mus musculus)
Mammalia Zfhx4 35
  • 88.73 (n)
  • 91.67 (a)
Zfhx4 16
Zfhx4 36
  • 92 (a)
(Monodelphis domestica)
Mammalia ZFHX4 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Zfhx4 35
  • 88.85 (n)
  • 92.21 (a)
(Gallus gallus)
Aves ZFHX4 35
  • 85.67 (n)
  • 90.61 (a)
ZFHX4 36
  • 91 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
-- 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9639 35
zfhx4 35
  • 78.72 (n)
  • 81.23 (a)
(Danio rerio)
Actinopterygii Dr.29679 35
zfhx4 35
  • 71.87 (n)
  • 72.37 (a)
zfhx4 36
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta zfh2 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea zfh-2 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
-- 36
  • 31 (a)
Species with no ortholog for ZFHX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFHX4 Gene

Gene Tree for ZFHX4 (if available)
Gene Tree for ZFHX4 (if available)

Paralogs for ZFHX4 Gene

Paralogs for ZFHX4 Gene

genes like me logo Genes that share paralogs with ZFHX4: view

Variants for ZFHX4 Gene

Sequence variations from dbSNP and Humsavar for ZFHX4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs714928 -- 76,723,201(+) GAATG(C/T)GTAAA intron-variant
rs714929 -- 76,723,053(+) TTATG(C/T)TTTAA intron-variant
rs726036 -- 76,796,808(-) CCTGT(A/C)TTTTC intron-variant
rs726037 -- 76,796,480(-) TAAGT(C/T)TTGAT intron-variant
rs729020 -- 76,813,207(+) GCAAA(C/T)GATTT intron-variant

Relevant External Links for ZFHX4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZFHX4 Gene

Disorders for ZFHX4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for ZFHX4 Gene including...

Search for ZFHX4 Gene in MalaCards »

(1) OMIM Diseases for ZFHX4 Gene (606940)


  • Note=A chromosomal aberration involving ZFHX4 is found in one patient with ptosis. Translocation t(1;8)(p34.3;q21.12).

(2) University of Copenhagen DISEASES for ZFHX4 Gene

Relevant External Links for ZFHX4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ZFHX4: view

Publications for ZFHX4 Gene

  1. A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation. (PMID: 11935336) McMullan T.W. … Robinson D.O. (Hum. Genet. 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A homeodomain-zinc finger protein, ZFHX4, is expressed in neuronal differentiation manner and suppressed in muscle differentiation manner. (PMID: 16946494) Hemmi K. … Tsuchiya K. (Biol. Pharm. Bull. 2006) 3 4
  4. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for ZFHX4 Gene

Sources for ZFHX4 Gene

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