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ZFHX4 Gene

protein-coding   GIFtS: 49
GCID: GC08P077593

Zinc Finger Homeobox 4

(Previous name: zinc finger homeodomain 4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Homeobox 41 2     ZHF42
Zinc Finger Homeodomain Protein 42 3     Zinc Finger Homeobox Protein 42
ZFH42 5     Zinc-Finger Homeodomain Protein 42
Zinc Finger Homeodomain 41     ZFH-43

External Ids:    HGNC: 309391   Entrez Gene: 797762   Ensembl: ENSG000000916567   OMIM: 6069405   UniProtKB: Q86UP33   

Export aliases for ZFHX4 gene to outside databases

Previous GC identifers: GC08P077778 GC08P073079


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZFHX4 Gene:
ZFHX4 (zinc finger homeobox 4) is a protein-coding gene. Diseases associated with ZFHX4 include ptosis, congenital, and chordoid glioma. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZFHX2.

UniProtKB/Swiss-Prot: ZFHX4_HUMAN, Q86UP3
Function: May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional
regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFHX4 gene promoter:
         SREBP-1c   Ik-3   SREBP-1b   GATA-2   AREB6   POU2F1   SREBP-1a   FOXO4   HOXA5   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFHX4 promoter sequence
   Search Chromatin IP Primers for ZFHX4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFHX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11   Ensembl cytogenetic band:  8q21.11   HGNC cytogenetic band: 8q21.11

ZFHX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFHX4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P077593:  view genomic region     (about GC identifiers)

Start:
77,593,454 bp from pter      End:
77,779,521 bp from pter
Size:
186,068 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZFHX4_HUMAN, Q86UP3 (See protein sequence)
Recommended Name: Zinc finger homeobox protein 4  
Size: 3567 amino acids; 393730 Da
Sequence caution: Sequence=AK131408; Type=Frameshift; Positions=338;
Secondary accessions: Q18PS0 Q6ZN20
Alternative splicing: 4 isoforms:  Q86UP3-1   Q86UP3-2   Q86UP3-4   Q86UP3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFHX4: NX_Q86UP3

Explore proteomics data for ZFHX4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZFHX4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078997.4  
    ENSEMBL proteins: 
     ENSP00000430497   ENSP00000428525   ENSP00000429495   ENSP00000427775   ENSP00000427739  
     ENSP00000430848   ENSP00000431101   ENSP00000430375   ENSP00000399605   ENSP00000050961  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFHX: Homeoboxes / ZF class

    Selected InterPro protein domains (see all 7):
     IPR003604 Znf_U1
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry Q86UP3

    ProtoNet protein and cluster: Q86UP3

    1 Blocks protein domain: IPB001400 Somatotropin hormone

    UniProtKB/Swiss-Prot: ZFHX4_HUMAN, Q86UP3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 20 C2H2-type zinc fingers
    Similarity: Contains 4 homeobox DNA-binding domains


    ZFHX4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFHX4_HUMAN, Q86UP3
    Function: May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional
    regulation

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003779actin binding ----
    GO:0008270zinc ion binding IEA--
         
    ZFHX4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZFHX4:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZFHX4
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    miRNA
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    miRTarBase miRNAs that target ZFHX4:
    hsa-mir-92a-3p (MIRT049269), hsa-mir-183-5p (MIRT047086), hsa-mir-19b-3p (MIRT050631), hsa-mir-128-3p (MIRT045872), hsa-let-7b-5p (MIRT052093), hsa-mir-296-3p (MIRT038424)

    Block miRNA regulation of human, mouse, rat ZFHX4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFHX4 (see all 256):
    hsa-miR-411* hsa-miR-579 hsa-miR-502-3p hsa-miR-1273d hsa-miR-200b hsa-miR-509-3-5p hsa-miR-520b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidZFHX4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZFHX4

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFHX4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZFHX4_HUMAN, Q86UP3: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZFHX4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFHX4
    Interactions:

        Search GeneGlobe Interaction Network for ZFHX4

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007010cytoskeleton organization ----

    ZFHX4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFHX4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZFHX4 gene: 
    NM_024721.4  

    Unigene Cluster for ZFHX4:

    Zinc finger homeobox 4
    Hs.458973  [show with all ESTs]
    Unigene Representative Sequence: NM_024721
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521891(uc003yau.2) ENST00000517683 ENST00000458716(uc003yat.1)
    ENST00000520307 ENST00000523885 ENST00000517585 ENST00000523809 ENST00000518282
    ENST00000523625 ENST00000524290 ENST00000519536 ENST00000522409 ENST00000455469
    ENST00000050961(uc003yaw.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZFHX4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFHX4 (see all 256):
    hsa-miR-411* hsa-miR-579 hsa-miR-502-3p hsa-miR-1273d hsa-miR-200b hsa-miR-509-3-5p hsa-miR-520b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidZFHX4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ZFHX4 (NM_024721)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZFHX4
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZFHX4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZFHX4
      QuantiTect SYBR Green Assays in human, mouse, rat ZFHX4
      QuantiFast Probe-based Assays in human, mouse, rat ZFHX4

    Additional mRNA sequence: 

    AB083343.2 AF086273.1 AK024633.1 AK095274.1 AK131399.1 AK131408.1 AK131462.1 AY260762.1 
    BC047745.2 BC074736.2 BC085610.1 BX649074.1 CR933619.1 

    22 DOTS entries:

    DT.100644832  DT.100765275  DT.100828814  DT.102836538  DT.120629224  DT.86836213  DT.100800295  DT.100799977 
    DT.102844601  DT.120629141  DT.100800288  DT.412680  DT.100828815  DT.120629190  DT.120629218  DT.430125 
    DT.100815944  DT.100828818  DT.100828819  DT.422895  DT.92449164  DT.95074020 

    Selected AceView cDNA sequences (see all 122):

    AI668935 AK131462 AW572579 T25122 AA338132 AK131399 NM_024721 BM671113 
    W69635 BM802958 BM931894 CA430749 BM462493 BM718499 BM762971 BC074736 
    AA383279 AA947161 BC047745 W69475 AY260762 BX282088 BX096196 CA440691 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZFHX4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:              -           -                 -     -     -           -                                                   
    SP2:                          -                       -                                                                     
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:              -                                                                                                         


    ECgene alternative splicing isoforms for ZFHX4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFHX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTCCTGGC
    ZFHX4 Expression
    About this image


    ZFHX4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
    ZFHX4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFHX4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458973

    UniProtKB/Swiss-Prot: ZFHX4_HUMAN, Q86UP3
    Tissue specificity: Expressed in brain, skeletal muscle and liver. Very low expression in stomach

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFHX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZFHX4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfhx41 , 5 zinc finger homeodomain 41, 5 88.73(n)1
    91.67(a)1
      3 (1.96 cM)5
    808921  NM_030708.21  NP_109633.21 
     52185265 
    chicken
    (Gallus gallus)
    Aves ZFHX41 zinc finger homeobox 4 85.67(n)
    90.61(a)
      395904  XM_425925.4  XP_425925.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    92(a)
    90(a)
    many → 1
    many → 1
    4(26330810-26491974)
    4(26310160-26330616)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.96392 Transcribed sequence with weak similarity to protein more 89.49(n)    BX691798.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.296792 Transcribed sequences 82.86(n)    CK400377.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta zfh26
    Zn finger homeodomain 2
    25(a)
    1 → many
    4(522436-560418)
    worm
    (Caenorhabditis elegans)
    Secernentea zfh-26
    Protein ZFH-2 (zfh-2) mRNA, complete cds
    33(a)
    1 → many
    I(803368-835277) WBGene00022518


    ENSEMBL Gene Tree for ZFHX4 (if available)
    TreeFam Gene Tree for ZFHX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZFHX4 gene
    ZFHX22  ZFHX32  
    2 SIMAP similar genes for ZFHX4 using alignment to 14 protein entries:     ZFHX4_HUMAN (see all proteins):
    ZFHX3    POU6F1

    ZFHX4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFHX4 (see all 3433)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889340051,2
    --77597621(+) TTCACC/TGCAGA 1 -- int10--------
    rs41435281,2
    C,F,H--77597656(+) TAGACC/TGTTTT 1 -- int15Minor allele frequency- T:0.13NS EA 538
    rs1925065361,2
    --77597747(+) GTGTTC/TGATTA 1 -- int10--------
    rs1121082961,2
    C,F--77597763(+) TAAAAG/AATATT 1 -- int12Minor allele frequency- A:0.03CSA WA 120
    rs1450873591,2
    --77597764(+) AAAAGA/GTATTG 1 -- int10--------
    rs1385935121,2
    --77597802(+) ATATAC/TGTACA 1 -- int10--------
    rs1830462121,2
    --77597819(+) TGCTTG/TAAAAA 1 -- int10--------
    rs1402750591,2
    C--77597865(+) CAATTA/GAAGCT 1 -- int10--------
    rs733473211,2
    C,F--77597959(+) AAGTAT/CTGGGG 1 -- int12Minor allele frequency- C:0.03WA 120
    rs1177144101,2
    C,F--77598019(+) CCATTG/TTTTAG 1 -- int11Minor allele frequency- T:0.02EA 120

    HapMap Linkage Disequilibrium report for ZFHX4 (77593454 - 77779521 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZFHX4: --
    Human Gene Mutation Database (HGMD): ZFHX4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFHX4
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFHX4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606940   
    OMIM disorders: 178300  
    UniProtKB/Swiss-Prot: ZFHX4_HUMAN, Q86UP3
  • Note=A chromosomal aberration involving ZFHX4 is found in one patient with ptosis. Translocation
    t(1;8)(p34.3;q21.12)

  • 12 diseases for ZFHX4:    
    About MalaCards
    ptosis, congenital    chordoid glioma    pineoblastoma    brain cancer
    tonsillitis    thyroiditis    multiple myeloma    myeloma
    cerebritis    neuronitis    prostatitis    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for ZFHX4:
    Chordoid glioma     Pineoblastoma

    ZFHX4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZFHX4
    Human Genome Epidemiology (HuGE) Navigator: ZFHX4 (6 documents)

    Export disorders for ZFHX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFHX4 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with ZFHX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation. (PubMed id 11935336)1, 2, 3 McMullan T.W.... Robinson D.O. (Hum. Genet. 2002)
    2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    6. A homeodomain-zinc finger protein, ZFHX4, is expressed in neuronal differentiation manner and suppressed in muscle differentiation manner. (PubMed id 16946494)1, 2 Hemmi K.... Tsuchiya K. (Biol. Pharm. Bull. 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The mouse ZFH-4 protein contains four homeodomains and twenty-two zinc fingers. (PubMed id 10873665)1, 3 Sakata N....Tamaoki T. (Biochem. Biophys. Res. Commun. 2000)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    10. Genome wide association study of age at menarche in the Japanese population. (PubMed id 23667675)1 Tanikawa C....Matsuda K. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79776 HGNC: 30939 AceView: ZFHX4 Ensembl:ENSG00000091656 euGenes: HUgn79776
    ECgene: ZFHX4 H-InvDB: ZFHX4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZFHX4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFHX4 gene:
    Search GeneIP for patents involving ZFHX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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