Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFHX4 Gene

protein-coding   GIFtS: 48
GCID: GC08P077593

zinc finger homeobox 4

(Previous name: zinc finger homeodomain 4 )
 Explore 5 diseases affiliated with
ZFHX4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZFHX4    

Aliases
for ZFHX4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Zinc Finger Homeobox 41 2     ZHF42
ZFH41 2 5     Zinc Finger Homeobox Protein 42
Zinc Finger Homeodomain Protein 42 3     Zinc-Finger Homeodomain Protein 42
FLJ209801     ZFH-43
Zinc Finger Homeodomain 41     

External Ids:    HGNC: 309391   Entrez Gene: 797762   Ensembl: ENSG000000916567   OMIM: 6069405   UniProtKB: Q86UP33   

Export aliases for ZFHX4 gene to outside databases

Previous GC identifers: GC08P077778 GC08P073079


Summaries
for ZFHX4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ZFHX4_HUMAN, Q86UP3
Function: May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional
regulation




Genomic Views
for ZFHX4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFHX4 gene promoter:
         SREBP-1c   Ik-3   SREBP-1b   GATA-2   AREB6   POU2F1   SREBP-1a   FOXO4   HOXA5   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZFHX4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFHX4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFHX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11   Ensembl cytogenetic band:  8q21.11   HGNC cytogenetic band: 8q21.11

ZFHX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFHX4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P077593:  view genomic region     (about GC identifiers)

Start:
 77,593,454 bp from pter      End:
 77,779,521 bp from pter
Size:
 186,068 bases      Orientation:
 plus strand

Proteins
for ZFHX4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZFHX4_HUMAN, Q86UP3 (See protein sequence)
Recommended Name: Zinc finger homeobox protein 4  
Size: 3567 amino acids; 393730 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AK131408; Type=Frameshift; Positions=338;
Secondary accessions: Q18PS0 Q6ZN20
Alternative splicing: 4 isoforms:  Q86UP3-1   Q86UP3-2   Q86UP3-4   Q86UP3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFHX4: NX_Q86UP3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86UP3

    • ZFHX4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_078997.4  
    ENSEMBL proteins: 
     ENSP00000430497   ENSP00000428595   ENSP00000428525   ENSP00000429495   ENSP00000427775  
     ENSP00000427739   ENSP00000430848   ENSP00000431101   ENSP00000430375   ENSP00000399605  
     ENSP00000050961  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for ZFHX4 
    GenScript Custom Purified and Recombinant Proteins Services for ZFHX4
    Novus Biologicals ZFHX4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZFHX4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    ZFHX4 for ontologies           About GeneDecksing



    ZFHX4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZFHX4 
    GenScript Custom Superior Antibodies Services for ZFHX4
    Novus Biologicals ZFHX4 Antibodies
    Search for Antibodies for ZFHX4 at Abcam  
    Uscn Antibodies for ZFHX4
    Search ThermoFisher Antibodies for ZFHX4

    Assay Products for ZFHX4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZFHX4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ZFHX4

    Protein Domains /
    Families
    for ZFHX4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZFHX4 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR015880 Znf_C2H2-like
     IPR003604 Znf_U1
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry Q86UP3

    ProtoNet protein and cluster: Q86UP3

    1 Blocks protein family: IPB001400 Somatotropin hormone

    UniProtKB/Swiss-Prot: ZFHX4_HUMAN, Q86UP3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 20 C2H2-type zinc fingers
    Similarity: Contains 4 homeobox DNA-binding domains


    Function
    for ZFHX4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZFHX4_HUMAN, Q86UP3
    Function: May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional
    regulation

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ZFHX4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFHX4
    8/256 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFHX4 (see all 256):
    hsa-miR-411* hsa-miR-579 hsa-miR-502-3p hsa-miR-1273d hsa-miR-200b hsa-miR-509-3-5p hsa-miR-520b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmid: ZFHX4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFHX4 (see all 4)
    OriGene shRNA RFP: ZFHX4
    OriGene siRNA: ZFHX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFHX4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ZFHX4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFHX4
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFHX4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ZFHX4 (NM_024721)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFHX4
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZFHX4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ZFHX4
    Search LifeMap BioReagents cell lines for ZFHX4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFHX4

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--


    ZFHX4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZFHX4:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for ZFHX4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFHX4

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--


    ZFHX4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZFHX4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFHX4
    Search CenterWatch for drugs/clinical trials and news about ZFHX4 

    Transcripts
    for ZFHX4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZFHX4 gene: 
    NM_024721.4  

    Unigene Cluster for ZFHX4:

    Zinc finger homeobox 4
    Hs.458973  [show with all ESTs]
    Unigene Representative Sequence: NM_024721
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521891(uc003yau.2) ENST00000517683 ENST00000458716(uc003yat.1)
    ENST00000520307 ENST00000523885 ENST00000517585 ENST00000523809 ENST00000518282
    ENST00000523625 ENST00000524290 ENST00000519536 ENST00000522409 ENST00000455469
    ENST00000050961(uc003yaw.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ZFHX4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFHX4
    8/256 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFHX4 (see all 256):
    hsa-miR-411* hsa-miR-579 hsa-miR-502-3p hsa-miR-1273d hsa-miR-200b hsa-miR-509-3-5p hsa-miR-520b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmid: ZFHX4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFHX4 (see all 4)
    OriGene shRNA RFP: ZFHX4
    OriGene siRNA: ZFHX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFHX4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFHX4
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFHX4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ZFHX4 (NM_024721)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFHX4
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZFHX4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFHX4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFHX4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFHX4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFHX4

    Additional cDNA sequence: 

    AB083343.2 AF086273.1 AK024633.1 AK095274.1 AK131399.1 AK131408.1 AK131462.1 AY260762.1 
    BC047745.2 BC074736.2 BC085610.1 BX649074.1 CR933619.1 

    22 DOTS entries:

    DT.100644832  DT.100765275  DT.100828814  DT.102836538  DT.120629224  DT.86836213  DT.100800295  DT.100799977 
    DT.102844601  DT.120629141  DT.100800288  DT.412680  DT.100828815  DT.120629190  DT.120629218  DT.430125 
    DT.100815944  DT.100828818  DT.100828819  DT.422895  DT.92449164  DT.95074020 

    24/122 AceView cDNA sequences (see all 122):

    W69475 AY260762 BX282088 AF086273 CA440691 AW298531 BX096196 N92063 
    AI668935 AK131462 BM671113 BC047745 AA383279 AA947161 BM718499 BC074736 
    BM762971 BM462493 CA430749 BM931894 BM802958 W69635 NM_024721 AK131399 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZFHX4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:              -           -                 -     -     -           -                                                   
    SP2:                          -                       -                                                                     
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:              -                                                                                                         


    ECgene alternative splicing isoforms for ZFHX4

    Expression
    for ZFHX4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFHX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGTCCTGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZFHX4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    EyeInner Nuclear LayerType1 Off Cone Bipolar CellsBipolar, Retina
    BrainMedulla OblongataBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    Posterior foregut-like cells (A scalable, suspensi...)

    See ZFHX4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFHX4

    SOURCE GeneReport for Unigene cluster: Hs.458973

    UniProtKB/Swiss-Prot: ZFHX4_HUMAN, Q86UP3
    Tissue specificity: Expressed in brain, skeletal muscle and liver. Very low expression in stomach

        SABiosciences Custom PCR Arrays for ZFHX4
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFHX4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFHX4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFHX4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFHX4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFHX4

    Orthologs
    for ZFHX4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ZFHX4 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zfhx41 , 5 zinc finger homeodomain 41, 5 89.1(n)1
    92.34(a)1    		   3 (1.96 cM)5
    808921  NM_030708.21  NP_109633.21 
     52185265 
    chicken
    (Gallus gallus)    		 Aves ZFHX41 zinc finger homeobox 4 85.04(n)
    89.81(a)    		   395904  XM_425925.3  XP_425925.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 92(a)
    90(a)
    		 many → 1
    many → 1
    		 4(26490333-26491928)
    4(26313772-26329458)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.96392 Transcribed sequence with weak similarity to protein more 89.49(n)    BX691798.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.296792 Transcribed sequences 82.86(n)    CK400377.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta zfh26
    		 Zn finger homeodomain 2
    		 21(a)
    		 1 → many
    		 4(522436-560418)
    worm
    (Caenorhabditis elegans)    		 Secernentea zfh-26
    		 Protein ZFH-2
    		 30(a)
    		 1 → many
    		 I(803371-834811)


    ENSEMBL Gene Tree for ZFHX4 (if available)
    TreeFam Gene Tree for ZFHX4 (if available) 

    Paralogs
    for ZFHX4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFHX4 gene
    ZFHX22  ZFHX32  
    3 SIMAP similar genes for ZFHX4 using alignment to 14 protein entries:     ZFHX4_HUMAN (see all proteins):
    ZFHX3    POU6F1    DUX4

    ZFHX4 for paralogs           About GeneDecksing



    Genomic Variants
    for ZFHX4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2863 NCBI SNPs in ZFHX4 are shown (see all 2863)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1415406751,2
    		--77591660(+) CACTAA/GTACCT 2 -- int1 us2k10--------
    rs1141558841,2
    		C,F,--77591693(+) GTGGTG/AATTTG 2 -- us2k1 int11Minor allele frequency- A:0.04WA 118
    rs768449001,2
    		F,--77591731(+) TAGGGG/TTTTTT 2 -- int1 us2k12Minor allele frequency- T:0.07NA EA 240
    rs1461694721,2
    		--77591768(+) CATTGA/TAACTT 2 -- us2k1 int10--------
    rs1381008171,2
    		--77591784(+) AGCTGC/TTGAAG 2 -- us2k1 int10--------
    rs758449921,2
    		F,--77592241(+) TAGTGC/TGAAGT 2 -- int1 us2k11Minor allele frequency- T:0.22EA 120
    rs64729811,2
    		C,A,H,--77592275(+) GCATAT/CATATA 2 -- int1 us2k13Minor allele frequency- C:0.17NA CSA 123
    rs2007343811,2
    		--77592299(+) ATATA-/TATATATATATA
    TATATTTTTTTTTT    TTTTC     		2 -- int1 us2k10--------
    rs2017322631,2
    		--77592697(+) CCCCA-/CCCCCC 2 -- int1 us2k10--------
    rs1824797091,2
    		--77592719(+) GCAACC/TGTCAC 2 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for ZFHX4 (77593454 - 77779521 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ZFHX4
         1 CNV: 95509
    Human Gene Mutation Database (HGMD): ZFHX4

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFHX4
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFHX4

    Disorders / Diseases
    for ZFHX4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZFHX4 for disorders           About GeneDecksing

    OMIM gene information: 606940   
    OMIM disorders: 178300  
    UniProtKB/Swiss-Prot: ZFHX4_HUMAN, Q86UP3
  • Note=A chromosomal aberration involving ZFHX4 is found in one patient with ptosis. Translocation
    • t(1;8)(p34.3;q21.12)

    5 diseases for ZFHX4:    About MalaCards
    ptosis, congenital    chordoid glioma    ptosis    pineoblastoma
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for ZFHX4:
    Chordoid glioma     Pineoblastoma
    Human Genome Epidemiology (HuGE) Navigator: ZFHX4 (6 documents)

    Export disorders for ZFHX4 gene to outside databases

    Publications
    for ZFHX4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFHX4 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with ZFHX4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation. (PubMed id 11935336)1, 2, 3 McMullan T.W.... Robinson D.O. (2002)
    2. A homeodomain-zinc finger protein, ZFHX4, is expressed in neuronal differentiation manner and suppressed in muscle differentiation manner. (PubMed id 16946494)1, 2 Hemmi K.... Tsuchiya K. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The mouse ZFH-4 protein contains four homeodomains and twenty-two zinc fingers. (PubMed id 10873665)1, 3 Sakata N....Tamaoki T. (2000)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1 Zhao J....Grant S.F. (2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    10. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

    External Searches for ZFHX4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZFHX4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79776 HGNC: 30939 AceView: ZFHX4 Ensembl:ENSG00000091656 euGenes: HUgn79776
    ECgene: ZFHX4 H-InvDB: ZFHX4

    Other Databases showing ZFHX4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZFHX4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFHX4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZFHX4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZFHX4 gene:
    Search GeneIP for patents involving ZFHX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ZFHX4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ZFHX4  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFHX4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFHX4  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ZFHX4   OriGene 3'-UTR Clone for ZFHX4  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFHX4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFHX4  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZFHX4   OriGene Custom Protein Services for ZFHX4  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZFHX4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFHX4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFHX4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFHX4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFHX4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFHX4
     GenScript Custom Purified and Recombinant Proteins Services for ZFHX4 GenScript cDNA clones with any tag delivered in your preferred vector for ZFHX4
     GenScript Custom Assay Services for ZFHX4 GenScript Custom Superior Antibodies Services for ZFHX4
     GenScript Custom overexpressing Cell Line Services for ZFHX4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ZFHX4 promoter
     Search Chromatin IP Primers for ZFHX4
     RT2 qPCR Primer Assay in human, mouse, rat ZFHX4
     Search GNC Networks for ZFHX4
     SABiosciences Custom PCR Arrays for ZFHX4
     Search Tocris compounds for ZFHX4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ZFHX4 antibodies
     ZFHX4 proteins
     Search for Antibodies for ZFHX4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ZFHX4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ZFHX4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ZFHX4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFHX4
     SwitchGear 3'UTR luciferase reporter plasmids for ZFHX4
     SwitchGear Promoter luciferase reporter plasmids for ZFHX4
     Search ThermoFisher Antibodies for ZFHX4
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZFHX4
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ZFHX4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4