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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZFHX3 Gene

protein-coding GIFtS: 51
GCID: GC16M072816

zinc finger homeobox 3

(Previous name: AT-binding transcription factor 1 )
(Previous symbol: ATBF1)

Explore 16 diseases affiliated with
ZFHX3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Homeobox 3¹ ²		ZFH-3² ³
ATBF1¹ ² ³ ⁵		ATBT²
AT-Binding Transcription Factor 1¹ ² ³		Alpha-Fetoprotein Enhancer Binding Protein²
ZNF927¹ ²		AT Motif-Binding Factor 1²
Alpha-Fetoprotein Enhancer-Binding Protein² ³		Zinc Finger Homeobox Protein 3²
Zinc Finger Homeodomain Protein 3² ³		AT Motif-Binding Factor³

External Ids:	HGNC: 777¹	Entrez Gene: 463²	Ensembl: ENSG00000140836⁷	OMIM: 104155⁵	UniProtKB: Q15911³

Export aliases for ZFHX3 gene to outside databases

Previous GC identifers: GC16M071374 GC16M058584

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZFHX3:

This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and

neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an

AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle

inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor

suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation.

Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for

this gene. (provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: ZFHX3_HUMAN, Q15911

Function: Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core

sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and

promoter repression. Down-regulates the MUC5AC promoter in gastric cancer

Gene Wiki entry for ZFHX3 (ATBF1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZFHX3 gene promoter:
E2F-4 E2F-3a E2F-5 Pbx1a E2F-2 c-Ets-1 E2F E2F-1 STAT3 c-Myb
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZFHX3 promoter sequence

Search SABiosciences Chromatin IP Primers for ZFHX3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFHX3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.3 Ensembl cytogenetic band: 16q22.3 HGNC cytogenetic band: 16q22.3

ZFHX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFHX3 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M072816: view genomic region (about GC identifiers)

Start:	72,816,784 bp from pter	End:	73,093,597 bp from pter
Size:	276,814 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZFHX3_HUMAN, Q15911 (See protein sequence)

Recommended Name: Zinc finger homeobox protein 3

Size: 3703 amino acids; 404419 Da

Subunit: Interacts with FNBP3 (By similarity). Interacts with PIAS3

Subcellular location: Nucleus

3 PDB 3D structures from and Proteopedia for ZFHX3:

2DA1 (3D)

2DA2 (3D)

2DA3 (3D)

Secondary accessions: D3DWS8 O15101 Q13719

Alternative splicing: 2 isoforms: Q15911-1 Q15911-2

Explore the universe of human proteins at neXtProt for ZFHX3: NX_Q15911

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15911

ZFHX3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001158238.1 NP_008816.3

ENSEMBL proteins:

ENSP00000268489 ENSP00000438926

Human Recombinant Protein Products:

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	Novus Biologicals ZFHX3 Protein
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	Uscn Proteins for ZFHX3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	1719379
GO:0005667	transcription factor complex	IDA	10318867
GO:0005739	mitochondrion	IEA	--

ZFHX3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ZFHX3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZFHX3 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR015880 Znf_C2H2-like

IPR003604 Znf_U1

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR017970 Homeobox_CS

IPR001356 Homeodomain

Graphical View of Domain Structure for InterPro Entry Q15911

ProtoNet protein and cluster: Q15911

UniProtKB/Swiss-Prot: ZFHX3_HUMAN, Q15911

Similarity: Contains 22 C2H2-type zinc fingers

Similarity: Contains 4 homeobox DNA-binding domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZFHX3_HUMAN, Q15911

Function: Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core

sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and

promoter repression. Down-regulates the MUC5AC promoter in gastric cancer

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ZFHX3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFHX3
		8/155 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFHX3 (see all 155):
		hsa-miR-194* hsa-miR-411* hsa-miR-579 hsa-miR-520f hsa-miR-376b hsa-miR-631 hsa-miR-128 hsa-miR-605

		SwitchGear 3'UTR luciferase reporter plasmid: ZFHX3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFHX3 (see all 4) OriGene shRNA RFP: ZFHX3 OriGene siRNA: ZFHX3
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFHX3

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	NAS	1719379
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	TAS	1719379
GO:0003924	GTPase activity	IEA	--
GO:0005525	GTP binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZFHX3 for ontologies About GeneDecksing

Animal Models:
8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Zfhx3):

behavior/neurological	endocrine/exocrine gland	growth/size	mortality/aging	normal
renal/urinary system	reproductive system	tumorigenesis

ZFHX3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ZFHX3

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/14 Interacting proteins for ZFHX3 (Q15911^{2, 3} ENSP00000268489⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NINL	Q9Y2I6²^,³, ENSP00000278886⁴	MINT-67232 I2D: score=4 STRING: ENSP00000278886
MYB	P10242³, ENSP00000339992⁴	I2D: score=2 STRING: ENSP00000339992
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
PIAS3	Q9Y6X2³, ENSP00000376765⁴	I2D: score=3 STRING: ENSP00000376765
GLI2	P10070³	I2D: score=4

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IGI	10318867
GO:0006355	regulation of transcription, DNA-dependent	TAS	1719379
GO:0006366	transcription from RNA polymerase II promoter	TAS	1719379
GO:0007517	muscle organ development	IEA	--
GO:0045662	negative regulation of myoblast differentiation	IDA	11312261

ZFHX3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ZFHX3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZFHX3
2 Novoseek chemical compound relationships for ZFHX3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	30.4	3	1719379 (1), 7507206 (1)
chloramphenicol	29.5	2	7507206 (1)

Search CenterWatch for drugs/clinical trials and news about ZFHX3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZFHX3 gene (2 alternative transcripts):

NM_001164766.1 NM_006885.3

Unigene Cluster for ZFHX3:

Zinc finger homeobox 3

Hs.598297 [show with all ESTs]

Unigene Representative Sequence: NM_006885

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000268489(uc002fck.3) ENST00000397992(uc002fcl.3) ENST00000563625

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ZFHX3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZFHX3
		8/155 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFHX3 (see all 155):
		hsa-miR-194* hsa-miR-411* hsa-miR-579 hsa-miR-520f hsa-miR-376b hsa-miR-631 hsa-miR-128 hsa-miR-605

		SwitchGear 3'UTR luciferase reporter plasmid: ZFHX3 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFHX3

Additional cDNA sequence:

AL133108.1 BC029653.1 BC043190.1 BX640748.1 D10250.1 L32832.1 L32833.1

6 DOTS entries:

DT.210568 DT.100741555 DT.120665756 DT.309675 DT.75158132 DT.91725465

24/170 AceView cDNA sequences (see all 170):

BE765790 BX501766 AI086404 AI417673 AA904494 BM684742 AI304888 AI351405

BM973237 H88486 AI288759 AI288766 BM721090 CD678593 BM930111 BM557333

BE765748 T27474 AA749358 BQ639252 AA741533 N66403 D10250 BM930871

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZFHX3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAACTTTCAA

About this image

ZFHX3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Type1 Off Cone Bipolar Cells

Bipolar, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

Syncytiotrophoblast-like cells (Generation of syncyt...)

Posterior foregut-like cells (A scalable, suspensi...)

Extraembryonic endoderm-like cells (Generation of extrae...)

See ZFHX3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZFHX3

SOURCE GeneReport for Unigene cluster: Hs.598297

UniProtKB/Swiss-Prot: ZFHX3_HUMAN, Q15911

Tissue specificity: Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level)

SABiosciences Custom PCR Arrays for ZFHX3

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFHX3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZFHX3 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ZFHX3¹	zinc finger homeobox 3	83.21(n) 89.32(a)		395682 XM_414230.3 XP_414230.3
lizard (Anolis carolinensis)	Reptilia	ZFHX3⁶	--	79(a)	1 ↔ 1	GL343483.1(436139-486325)
African clawed frog (Xenopus laevis)	Amphibia	Xl.31945²	Xenopus laevis transcribed sequence with weak similarity more	80.46(n)		CF522627.1
zebrafish (Danio rerio)	Actinopterygii	zfhx3¹	zinc finger homeobox 3	67.22(n) 69.54(a)		100333211 XM_002663002.2 XP_002663048.2
fruit fly (Drosophila melanogaster)	Insecta	zfh2⁶	Zn finger homeodomain 2	22(a)	1 → many	4(522436-560418)
worm (Caenorhabditis elegans)	Secernentea	zfh-2⁶	Protein ZFH-2	32(a)	1 → many	I(803371-834811)

ENSEMBL Gene Tree for ZFHX3 (if available)
TreeFam Gene Tree for ZFHX3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZFHX3 gene

ZFHX2² ZFHX4²

2 SIMAP similar genes for ZFHX3 using alignment to 2 protein entries: ZFHX3_HUMAN (see all proteins):

ZFHX4 POU6F1

ZFHX3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: ZFHX3_HUMAN, Q15911

Polymorphism: Genetic variations in ZFHX3 are associated with atrial fibrillation and ischemic stroke in individuals of

European ancestry

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72793287^1,2	C,	--	58584536(+)	`TGGCTA/GTCAAT`	2	--	ds500¹		0	--	--	--	--
rs114943360^1,2	C,F,	--	58586587(+)	`TATATA/GTATTT`	2	--	ut3¹		1		WA	118
rs200323038^1,2	C	--	58588615(+)	`TGGAAA/CAAAAA`	2	--	ut3¹		0	--	--	--	--
rs72793288^1,2	C,	--	58588618(+)	`AACAAA/CAAAAA`	2	--	ut3¹		0	--	--	--	--
rs8044440^1,2	H	--	58590046(+)	`TTCTGG/CTTTGG`	4	/P /A	mis¹ ese³		6		NS EA NA	420
rs56297017^1,2	C	--	58591096(+)	`ATACTC/TCCCCT`	2	--	int¹		0	--	--	--	--
rs56268740^1,2	C	--	58591097(+)	`TACTTC/TCCCTT`	2	--	int¹		0	--	--	--	--
rs56014152^1,2	C	--	58591106(+)	`TTTCAA/GCCAAA`	2	--	int¹		0	--	--	--	--
rs76587297^1,2		--	58591526(+)	`AGAGCG/TGCAAC`	2	--	int¹		1		NA	120
rs57678445^1,2	C,	--	58592027(+)	`TCACCA/GGGCCC`	2	--	int¹		2		WA	120

HapMap Linkage Disequilibrium report for ZFHX3 (72816784 - 73066784 bp, first 250kb of ZFHX3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZFHX3
1 CNV: 67032
1 Indel: 58773
Human Gene Mutation Database (HGMD): ZFHX3

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing ZFHX3:

Gastric Cancer

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFHX3

DNA2.0 Custom Variant and Variant Library Synthesis for ZFHX3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZFHX3 for disorders           About GeneDecksing

OMIM gene information: 104155
OMIM disorders: 176807
16 diseases for ZFHX3:    About MalaCards

atrial fibrillation ventricular fibrillation myocardial infarction acute myocardial infarction

neuronitis prostate cancer kawasaki disease gastric cancer

breast cancer prostatitis hepatocellular carcinoma cervical cancer

cervicitis carcinoma neuroblastoma schizophrenia

7 Novoseek disease relationships for ZFHX3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
somatic mutations	56.6	6	18312352 (2), 16267836 (1), 16637072 (1), 15750593 (1)
gastric cancer	48.8	15	17330845 (4), 17671116 (3), 11314020 (2), 14978340 (1)
prostate cancer	32.7	6	16637072 (2), 15750593 (2), 16932943 (1), 16267836 (1)
tumors	16.6	4	16932943 (1), 16637072 (1), 17330845 (1), 18416817 (1)
cancer	11.5	4	11812077 (1), 14978340 (1), 15750593 (1), 17671116 (1)
breast cancer	4.36	8	16932943 (4), 18416817 (2), 15671546 (1)
carcinoma	0	1	14654895 (1)

Human Genome Epidemiology (HuGE) Navigator: ZFHX3 (8 documents)

Export disorders for ZFHX3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ZFHX3 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with ZFHX3)

Utopia: connect your pdf to the dynamic
world of online information

A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers. (PubMed id 1719379)^{1, 2, 3, 9} Morinaga T.... Tamaoki T. (1991)
Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner. (PubMed id 7592926)^{1, 2, 3, 9} Miura Y....Tamaoki T. (1995)
Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer. (PubMed id 17330845)^{1, 2, 9} Mori Y.... Joh T. (2007)
Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1. (PubMed id 11312261)^{1, 2, 9} Berry F.B.... Tamaoki T. (2001)
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. (PubMed id 19597492)^{1, 2} Benjamin E.J....Witteman J.C.M. (2009)
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. (PubMed id 19597491)^{1, 2} Gudbjartsson D.F....Stefansson K. (2009)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)^{1, 2} Martin J.... Pennacchio L.A. (2004)
ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3. (PubMed id 14715251)^{1, 2} Nojiri S.... Ito M. (2004)
Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)^{1, 2} Loftus B.J.... Adams M.D. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 463	HGNC: 777	AceView: ATBF1	Ensembl:ENSG00000140836	euGenes: HUgn463
ECgene: ZFHX3	H-InvDB: ZFHX3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ZFHX3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ZFHX3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ZFHX3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ZFHX3 gene:
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