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ZFHX3 Gene

protein-coding   GIFtS: 53
GCID: GC16M072816

Zinc Finger Homeobox 3

(Previous name: AT-binding transcription factor 1)
(Previous symbol: ATBF1)
  See ZFHX3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Homeobox 31 2     AT Motif-Binding Factor 12 3
ATBF11 2 3 5     ATBT2
AT-Binding Transcription Factor 11 2 3     ZNF9272
Alpha-Fetoprotein Enhancer-Binding Protein2 3     Alpha-Fetoprotein Enhancer Binding Protein2
Zinc Finger Homeodomain Protein 32 3     Zinc Finger Homeobox Protein 32
ZFH-32 3     

External Ids:    HGNC: 7771   Entrez Gene: 4632   Ensembl: ENSG000001408367   OMIM: 1041555   UniProtKB: Q159113   

Export aliases for ZFHX3 gene to outside databases

Previous GC identifers: GC16M071374 GC16M058584


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZFHX3 Gene:
This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic
and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding
to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the
cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to
function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with
atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different
isoforms have been found for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for ZFHX3 Gene:
ZFHX3 (zinc finger homeobox 3) is a protein-coding gene. Diseases associated with ZFHX3 include prostate cancer. GO annotations related to this gene include enzyme binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZFHX2.

UniProtKB/Swiss-Prot: ZFHX3_HUMAN, Q15911
Function: Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich
core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6
promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer

Gene Wiki entry for ZFHX3 (ATBF1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFHX3 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pbx1a   E2F-2   c-Ets-1   E2F   E2F-1   STAT3   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFHX3 promoter sequence
   Search Chromatin IP Primers for ZFHX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFHX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.3   Ensembl cytogenetic band:  16q22.3   HGNC cytogenetic band: 16q22.3

ZFHX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFHX3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M072816:  view genomic region     (about GC identifiers)

Start:
72,816,784 bp from pter      End:
73,093,597 bp from pter
Size:
276,814 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZFHX3_HUMAN, Q15911 (See protein sequence)
Recommended Name: Zinc finger homeobox protein 3  
Size: 3703 amino acids; 404419 Da
Subunit: Interacts with FNBP3 (By similarity). Interacts with ALKBH4 and PIAS3
3 PDB 3D structures from and Proteopedia for ZFHX3:
2DA1 (3D)        2DA2 (3D)        2DA3 (3D)    
Secondary accessions: D3DWS8 O15101 Q13719
Alternative splicing: 2 isoforms:  Q15911-1   Q15911-2   

Explore the universe of human proteins at neXtProt for ZFHX3: NX_Q15911

Explore proteomics data for ZFHX3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZFHX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001158238.1  NP_008816.3  

    ENSEMBL proteins: 
     ENSP00000268489   ENSP00000438926  

    ZFHX3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFHX: Homeoboxes / ZF class
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 7):
     IPR003604 Znf_U1
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry Q15911

    ProtoNet protein and cluster: Q15911

    UniProtKB/Swiss-Prot: ZFHX3_HUMAN, Q15911
    Similarity: Contains 22 C2H2-type zinc fingers
    Similarity: Contains 4 homeobox DNA-binding domains


    Find genes that share domains with ZFHX3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFHX3_HUMAN, Q15911
    Function: Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich
    core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6
    promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS1719379
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity TAS1719379
    GO:0003779actin binding ----
         
    Find genes that share ontologies with ZFHX3           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Zfhx3):
     behavior/neurological  endocrine/exocrine gland  growth/size/body  mortality/aging  normal 
     renal/urinary system  reproductive system  tumorigenesis 

    Find genes that share phenotypes with ZFHX3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZFHX3
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    miRNA
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    miRTarBase miRNAs that target ZFHX3:
    hsa-mir-16-5p (MIRT031857), hsa-mir-181b-5p (MIRT047244), hsa-mir-103a-3p (MIRT027177), hsa-mir-340-5p (MIRT019620), hsa-mir-98-5p (MIRT027754), hsa-mir-532-5p (MIRT040982)

    Block miRNA regulation of human, mouse, rat ZFHX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFHX3 (see all 155):
    hsa-miR-194* hsa-miR-411* hsa-miR-579 hsa-miR-520f hsa-miR-376b hsa-miR-631 hsa-miR-128 hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidZFHX3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZFHX3

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFHX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFHX3
    Addgene plasmids for ZFHX3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFHX3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZFHX3_HUMAN, Q15911: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS1719379
    GO:0005667transcription factor complex IDA10318867
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with ZFHX3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ZFHX3
        Transcriptional Regulatory Network in Embryonic Stem Cell


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFHX3
    Interactions:

        GeneGlobe Interaction Network for ZFHX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for ZFHX3 (Q159112, 3 ENSP000002684894) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NINLQ9Y2I62, 3, ENSP000002788864MINT-67232 I2D: score=4 STRING: ENSP00000278886
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    ENSG00000233911Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IGI10318867
    GO:0006355regulation of transcription, DNA-templated TAS1719379
    GO:0006366transcription from RNA polymerase II promoter TAS1719379
    GO:0007010cytoskeleton organization ----
    GO:0007050cell cycle arrest IEA--

    Find genes that share ontologies with ZFHX3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFHX3

    2 Novoseek inferred chemical compound relationships for ZFHX3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 30.4 3 1719379 (1), 7507206 (1)
    chloramphenicol 29.5 2 7507206 (1)



    Find genes that share compounds with ZFHX3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZFHX3 gene (2 alternative transcripts): 
    NM_001164766.1  NM_006885.3  

    Unigene Cluster for ZFHX3:

    Zinc finger homeobox 3
    Hs.598297  [show with all ESTs]
    Unigene Representative Sequence: NM_006885
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268489(uc002fck.3) ENST00000397992(uc002fcl.3) ENST00000563625
    ENST00000558842
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZFHX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFHX3 (see all 155):
    hsa-miR-194* hsa-miR-411* hsa-miR-579 hsa-miR-520f hsa-miR-376b hsa-miR-631 hsa-miR-128 hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidZFHX3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZFHX3
    Predesigned siRNA for gene silencing in human, mouse, rat ZFHX3
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZFHX3 (NM_006885)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZFHX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFHX3
    Addgene plasmids for ZFHX3 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZFHX3
      QuantiTect SYBR Green Assays in human, mouse, rat ZFHX3
      QuantiFast Probe-based Assays in human, mouse, rat ZFHX3

    Additional mRNA sequence: 

    AL133108.1 BC029653.1 BC043190.1 BX640748.1 D10250.1 L32832.1 L32833.1 

    6 DOTS entries:

    DT.210568  DT.100741555  DT.120665756  DT.309675  DT.75158132  DT.91725465 

    Selected AceView cDNA sequences (see all 170):

    AA741533 AI288766 BQ639252 AL135615 BM721090 CD245175 AI351405 BM973237 
    D10250 AA749358 BE765790 N66403 AI304888 H88486 CD678593 BM930111 
    AI417673 BM930871 BM557333 T27474 BX501766 AI086404 BM684742 AI288759 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFHX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAACTTTCAA
    ZFHX3 Expression
    About this image


    ZFHX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
    ZFHX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFHX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.598297

    UniProtKB/Swiss-Prot: ZFHX3_HUMAN, Q15911
    Tissue specificity: Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFHX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZFHX3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfhx31 , 5 zinc finger homeobox 31, 5 89.93(n)1
    94.66(a)1
      8 (56.02 cM)5
    119061  NM_007496.21  NP_031522.21 
     1087146445 
    chicken
    (Gallus gallus)
    Aves ZFHX31 zinc finger homeobox 3 82.49(n)
    87.9(a)
      395682  XM_004944340.1  XP_004944397.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZFHX36
    zinc finger homeobox 3
    80(a)
    1 ↔ 1
    GL343483.1(436139-486325)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.319452 Xenopus laevis transcribed sequence with weak similarity more 80.46(n)    CF522627.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zfhx31 zinc finger homeobox 3 67.38(n)
    69.35(a)
      100333211  XM_002663002.3  XP_002663048.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta zfh26
    Zn finger homeodomain 2
    25(a)
    1 → many
    4(522436-560418)
    worm
    (Caenorhabditis elegans)
    Secernentea zfh-26
    Protein ZFH-2 (zfh-2) mRNA, complete cds
    33(a)
    1 → many
    I(803368-835277) WBGene00022518


    ENSEMBL Gene Tree for ZFHX3 (if available)
    TreeFam Gene Tree for ZFHX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for ZFHX3 gene
    ZFHX22  ZFHX42  
    2 SIMAP similar genes for ZFHX3 using alignment to 2 protein entries:     ZFHX3_HUMAN (see all proteins):
    ZFHX4    POU6F1

    Find genes that share paralogs with ZFHX3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ZFHX3_HUMAN, Q15911: Genetic variations in ZFHX3 are associated with atrial fibrillation and ischemic stroke in
    individuals of European ancestry


    Selected SNPs for ZFHX3 (see all 6478)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017723571,2
    C--58589757(+) CGCCGC/TCGCCG 4 D G mis10--------
    rs2005611331,2
    C--58589770(+) GCCACC/TGCCAC 4 S G mis10--------
    rs2019783001,2
    C--58589788(+) GCCGCC/GGGTGG 4 R G mis10--------
    rs772884941,2
    F--58721972(+) ACTATG/CTTGAC 2 -- int11Minor allele frequency- C:0.50NA 2
    rs339677711,2
    C--58758700(+) GGGGA-/CATTTA 2 -- int10--------
    rs1401930921,2
    C--58763813(+) ACAGT-/AAAC  
      CAAACC
    AAACC
    2 -- int10--------
    rs113144551,2
    C,F--58766597(+) AAAAAA/-GGAAA 2 -- int1 trp32Minor allele frequency- -:0.50NA 4
    rs1381453891,2
    C--58776493(+) GGGCA-/ACAC  
            
    ACACA
    2 -- int10--------
    rs1423238881,2
    C--58805442(+) TGAGA-/C/CC  
            
    CCCCC
    2 -- int10--------
    rs58178221,2
    C--58810845(+) TATAC-/GTGT  
            
    GTGTG
    2 -- int10--------

    HapMap Linkage Disequilibrium report for ZFHX3 (72816784 - 73066784 bp, first 250kb of ZFHX3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZFHX3 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672800CNV Deletion23128226
    nsv1869CNV Insertion18451855
    esv268829CNV Insertion20981092
    esv29824CNV Loss19812545
    nsv906898CNV Loss21882294
    nsv1868CNV Loss18451855
    nsv827733CNV Gain20364138
    nsv827734CNV Gain20364138
    dgv487n67CNV Gain20364138
    nsv819379CNV Gain19587683

    Human Gene Mutation Database (HGMD): ZFHX3
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing ZFHX3:
    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing ZFHX3
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFHX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 104155   
    OMIM disorders: 176807  
    1 disease for ZFHX3:    
    About MalaCards
    prostate cancer


    Find genes that share disorders with ZFHX3           About GenesLikeMe

    7 Novoseek inferred disease relationships for ZFHX3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    somatic mutations 56.6 6 18312352 (2), 16267836 (1), 16637072 (1), 15750593 (1)
    gastric cancer 48.8 15 17330845 (4), 17671116 (3), 11314020 (2), 14978340 (1)
    prostate cancer 32.7 6 16637072 (2), 15750593 (2), 16932943 (1), 16267836 (1)
    tumors 16.6 4 16932943 (1), 16637072 (1), 17330845 (1), 18416817 (1)
    cancer 11.5 4 11812077 (1), 14978340 (1), 15750593 (1), 17671116 (1)
    breast cancer 4.36 8 16932943 (4), 18416817 (2), 15671546 (1)
    carcinoma 0 1 14654895 (1)

    Genetic Association Database (GAD): ZFHX3
    Human Genome Epidemiology (HuGE) Navigator: ZFHX3 (8 documents)

    Export disorders for ZFHX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFHX3 gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with ZFHX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers. (PubMed id 1719379)1, 2, 3, 9 Morinaga T.... Tamaoki T. (Mol. Cell. Biol. 1991)
    2. Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner. (PubMed id 7592926)1, 2, 3, 9 Miura Y....Tamaoki T. (J. Biol. Chem. 1995)
    3. Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. (PubMed id 19597492)1, 2, 4 Benjamin E.J....Witteman J.C.M. (Nat. Genet. 2009)
    4. A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. (PubMed id 19597491)1, 2, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2009)
    5. Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer. (PubMed id 17330845)1, 2, 9 Mori Y.... Joh T. (Int. J. Cancer 2007)
    6. Germline ATBF1 mutations and prostate cancer risk. (PubMed id 16637072)1, 4, 9 Xu J....Isaacs W.B. (Prostate 2006)
    7. Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1. (PubMed id 11312261)1, 2, 9 Berry F.B.... Tamaoki T. (J. Biol. Chem. 2001)
    8. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PubMed id 21347282)1, 4 Lettre G....Boerwinkle E. (PLoS Genet. 2011)
    9. A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. (PubMed id 19132087)1, 4 Burgner D....Hibberd M.L. (PLoS Genet. 2009)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 463 HGNC: 777 AceView: ATBF1 Ensembl:ENSG00000140836 euGenes: HUgn463
    ECgene: ZFHX3 H-InvDB: ZFHX3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZFHX3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZFHX3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZFHX3 gene:
    Search GeneIP for patents involving ZFHX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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