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ZFHX2 Gene

protein-coding GIFtS: 41
GCID: GC14M023990

Zinc Finger Homeobox 2

(Previous name: zinc finger protein 409)
(Previous symbol: ZNF409)

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disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Zinc Finger Homeobox 2¹ ²		ZFH-5²
ZNF409¹ ² ³		Zinc Finger Homeobox Protein 2²
Zinc Finger Protein 409¹ ²		KIAA1056³
Zinc Finger Homeodomain Protein 2² ³		KIAA1762³
ZFH-2² ³

External Ids:	HGNC: 20152¹	Entrez Gene: 85446²	Ensembl: ENSG00000136367⁷	UniProtKB: Q9C0A1³

Export aliases for ZFHX2 gene to outside databases

Previous GC identifers: GC14M017777 GC14M021981 GC14M021982 GC14M021983 GC14M023059

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZFHX2 Gene:

ZFHX2 (zinc finger homeobox 2) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZFHX4.

UniProtKB/Swiss-Prot: ZFHX2_HUMAN, Q9C0A1

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000014.8 NT_026437.13 NC_018925.2

Regulatory elements:

Regulatory transcription factor binding sites in the ZFHX2 gene promoter:
AP-2gamma Meis-1b GATA-2 GATA-1 YY1 HOXA5 AP-2beta AP-2alpha Meis-1 AP-2alphaA
Other transcription factors

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Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFHX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2

ZFHX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFHX2 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M023990: view genomic region (about GC identifiers)

Start:	23,990,064 bp from pter	End:	24,025,401 bp from pter
Size:	35,338 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
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About This Section

UniProtKB/Swiss-Prot: ZFHX2_HUMAN, Q9C0A1 (See protein sequence)

Recommended Name: Zinc finger homeobox protein 2

Size: 2572 amino acids; 274176 Da

Sequence caution: Sequence=BAA83008.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: Q9UPU6

Alternative splicing: 2 isoforms: Q9C0A1-1 Q9C0A1-2

Explore the universe of human proteins at neXtProt for ZFHX2: NX_Q9C0A1

Explore proteomics data for ZFHX2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See ZFHX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_207646.2

ENSEMBL proteins:

ENSP00000413418 ENSP00000409464 ENSP00000451342

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

ZFHX: Homeoboxes / ZF class

ZNF: Zinc fingers, C2H2-type

Selected InterPro protein domains (see all 8):

IPR027028 ZFHX2

IPR003604 Znf_U1

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR017970 Homeobox_CS

Graphical View of Domain Structure for InterPro Entry Q9C0A1

ProtoNet protein and cluster: Q9C0A1

UniProtKB/Swiss-Prot: ZFHX2_HUMAN, Q9C0A1

Similarity: Contains 13 C2H2-type zinc fingers

Similarity: Contains 3 homeobox DNA-binding domains

Find genes that share domains with ZFHX2 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZFHX2_HUMAN, Q9C0A1

Function: May be involved in transcriptional regulation

Gene Ontology (GO): Selected molecular function terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0003779	actin binding	--	--
GO:0008270	zinc ion binding	IEA	--

Find genes that share ontologies with ZFHX2 About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for ZFHX2:

Increased gamma-H2AX phosphory

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Zfhx2):

no phenotypic analysis

Find genes that share phenotypes with ZFHX2 About GenesLikeMe

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genOway: Develop your customized and physiologically relevant rodent model for ZFHX2

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

ZFHX2_HUMAN, Q9C0A1: Nucleus (Probable)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	4
cytosol	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

Find genes that share ontologies with ZFHX2 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

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Interactions:

Search GeneGlobe Interaction Network for ZFHX2

Gene Ontology (GO): 4 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-templated	IEA	--
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0007010	cytoskeleton organization	--	--
GO:0030534	adult behavior	IEA	--

Find genes that share ontologies with ZFHX2 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
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About This Section

REFSEQ mRNAs for ZFHX2 gene (4 alternative transcripts):

NM_033400.2 XM_005268134.1 XM_005268135.1 XM_006720282.1

Unigene Cluster for ZFHX2:

Zinc finger homeobox 2

Hs.508937 [show with all ESTs]

Unigene Representative Sequence: NM_033400

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000419474(uc010akq.3 uc001wke.3) ENST00000606808 ENST00000412565

ENST00000555334

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Additional mRNA sequence:

AB028979.1 AB051549.1 BC144336.1 BC150606.1

6 DOTS entries:

DT.105925 DT.40310148 DT.75121693 DT.92037350 DT.91868937 DT.92424855

Selected AceView cDNA sequences (see all 33):

BM928251 BM142009 AB051549 CK819828 BM141735 BE673662 BM930209 BX283301

AA210939 BU688647 BE393586 AV704837 CK819827 BQ889378 AA535789 CF130285

AA976107 BU953894 AI582864 AI093184 BM683686 AW470308 AI216808 AA781938

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZFHX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATGTTCCACT

About this image

ZFHX2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ZFHX2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.508937

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZFHX2 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zfhx2^{1 , 5}	zinc finger homeobox 2^{1, 5}	85.52(n)¹ 84.51(a)¹		14 (28.05 cM)⁵ 239102¹ NM_001039198.1¹ NP_001034287.1¹ 55060262⁵
lizard (Anolis carolinensis)	Reptilia	ZFHX2⁶	zinc finger homeobox 2	55(a)	1 ↔ 1	GL343680.1(15685-29581)
tropical clawed frog (Xenopus tropicalis)	Amphibia	zfhx2¹	zinc finger homeobox 2	54.18(n) 50.5(a)		100489378 XM_002941515.2 XP_002941561.2
zebrafish (Danio rerio)	Actinopterygii	zfhx2⁶	zinc finger homeobox 2	17(a)	1 ↔ 1	24(14482670-14496307) ENSDARG00000088880
fruit fly (Drosophila melanogaster)	Insecta	zfh2⁶	Zn finger homeodomain 2	15(a)	1 → many	4(522436-560418)
worm (Caenorhabditis elegans)	Secernentea	zfh-2⁶	Protein ZFH-2 (zfh-2) mRNA, complete cds	24(a)	1 → many	I(803368-835277) WBGene00022518

ENSEMBL Gene Tree for ZFHX2 (if available)
TreeFam Gene Tree for ZFHX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for ZFHX2 gene

ZFHX4² ZFHX3²

2 SIMAP similar genes for ZFHX2 using alignment to 6 protein entries: ZFHX2_HUMAN (see all proteins):

POU6F1 NKX2-5

Find genes that share paralogs with ZFHX2 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Structural Variations
Database of Genomic Variants (DGV) 1 variation for ZFHX2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv524778	CNV	Loss	19592680

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About This Section

Find genes that share disorders with ZFHX2 About GenesLikeMe

Genetic Association Database (GAD): ZFHX2

Export disorders for ZFHX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZFHX2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZFHX2)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)^{1, 2, 3} Nagase T.... Ohara O. (DNA Res. 2000)
Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)^{1, 3} Kikuno R.... Ohara O. (DNA Res. 1999)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (amp 2008)
Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. (PubMed id 15161980)¹ Li T.... Chock P.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)² Heilig R.... Weissenbach J. (Nature 2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)¹ Dias Neto E....Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 85446	HGNC: 20152	AceView: ZFHX2	Ensembl:ENSG00000136367	euGenes: HUgn85446
ECgene: ZFHX2	H-InvDB: ZFHX2

(According to HUGE)
About This Section

HUGE: KIAA1056 KIAA1762

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZFHX2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZFHX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZFHX2 gene:
Search GeneIP for patents involving ZFHX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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Hot genes Disease genes ZFHX2 gene at Home site.

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ZFHX2 Gene

Zinc Finger Homeobox 2

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ZFHX2 Gene

Zinc Finger Homeobox 2

Aliasesfor ZFHX2 gene

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ZFHX2 Human Recombinant Protein Products:

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