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Aliases for ZFHX2 Gene

Aliases for ZFHX2 Gene

  • Zinc Finger Homeobox 2 2 3 5
  • Zinc Finger Homeodomain Protein 2 3 4
  • Zinc Finger Protein 409 2 3
  • ZNF409 3 4
  • ZFH-2 3 4
  • Zinc Finger Homeobox Protein 2 3
  • KIAA1056 4
  • KIAA1762 4
  • ZFH-5 3

External Ids for ZFHX2 Gene

Previous HGNC Symbols for ZFHX2 Gene

  • ZNF409

Previous GeneCards Identifiers for ZFHX2 Gene

  • GC14M017777
  • GC14M021981
  • GC14M021982
  • GC14M021983
  • GC14M023059
  • GC14M023990

Summaries for ZFHX2 Gene

GeneCards Summary for ZFHX2 Gene

ZFHX2 (Zinc Finger Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and actin binding. An important paralog of this gene is ZFHX3.

UniProtKB/Swiss-Prot for ZFHX2 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFHX2 Gene

Genomics for ZFHX2 Gene

Regulatory Elements for ZFHX2 Gene

Enhancers for ZFHX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F023478 0.6 ENCODE 12 +77.6 77556 0.9 ELF3 CTCF ATF1 SAP130 ARID4B ZNF384 ZSCAN9 RAD21 GATA3 POLR2A ENSG00000157306 ZFHX2 THTPA AP1G2 MYH7 MIR208B NGDN
GH14F023530 0.2 Ensembl 11.8 +25.4 25392 0.8 SMARCA4 PLRG1 EGR2 EFS ZFHX2 NYNRIN NFATC4 MYH6 DHRS4 ENSG00000273618
GH14F023484 0.5 ENCODE 11.7 +70.5 70498 1.4 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000157306 ZFHX2 THTPA NGDN
GH14F023588 0.6 Ensembl ENCODE 11.6 -33.0 -33024 1.2 PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZFHX2 ENSG00000157306 HOMEZ JPH4 ENSG00000274002
GH14F023577 0.6 ENCODE 11.3 -22.6 -22595 2.2 MAZ NFIA ETV1 ZMYM3 NR3C1 GABPA ZFHX2 JUND SMARCA4 POLR2A ZFHX2 ENSG00000157306 JPH4 DHRS4-AS1 AP1G2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZFHX2 on UCSC Golden Path with GeneCards custom track

Promoters for ZFHX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000096928 -8 1601 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for ZFHX2 Gene

Chromosome:
14
Start:
23,520,855 bp from pter
End:
23,556,192 bp from pter
Size:
35,338 bases
Orientation:
Minus strand

Genomic View for ZFHX2 Gene

Genes around ZFHX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFHX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFHX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFHX2 Gene

Proteins for ZFHX2 Gene

  • Protein details for ZFHX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0A1-ZFHX2_HUMAN
    Recommended name:
    Zinc finger homeobox protein 2
    Protein Accession:
    Q9C0A1
    Secondary Accessions:
    • Q9UPU6

    Protein attributes for ZFHX2 Gene

    Size:
    2572 amino acids
    Molecular mass:
    274176 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA83008.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFHX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFHX2 Gene

Post-translational modifications for ZFHX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFHX2 Gene

Domains & Families for ZFHX2 Gene

Suggested Antigen Peptide Sequences for ZFHX2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C0A1

UniProtKB/Swiss-Prot:

ZFHX2_HUMAN :
  • Contains 3 homeobox DNA-binding domains.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • Contains 3 homeobox DNA-binding domains.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZFHX2: view

Function for ZFHX2 Gene

Molecular function for ZFHX2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZFHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFHX2: view
genes like me logo Genes that share phenotypes with ZFHX2: view

Animal Models for ZFHX2 Gene

MGI Knock Outs for ZFHX2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZFHX2 Gene

Localization for ZFHX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFHX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFHX2 Gene COMPARTMENTS Subcellular localization image for ZFHX2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZFHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFHX2: view

Pathways & Interactions for ZFHX2 Gene

SuperPathways for ZFHX2 Gene

No Data Available

Interacting Proteins for ZFHX2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000413418%0d%0a9606.ENSP00000376076%0d%0a
Selected Interacting proteins: ENSP00000413418 Q9C0A1-ZFHX2_HUMAN for ZFHX2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ZFHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030534 adult behavior IEA --
genes like me logo Genes that share ontologies with ZFHX2: view

No data available for Pathways by source and SIGNOR curated interactions for ZFHX2 Gene

Transcripts for ZFHX2 Gene

Unigene Clusters for ZFHX2 Gene

Zinc finger homeobox 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFHX2 Gene

No ASD Table

Relevant External Links for ZFHX2 Gene

GeneLoc Exon Structure for
ZFHX2
ECgene alternative splicing isoforms for
ZFHX2

Expression for ZFHX2 Gene

mRNA expression in normal human tissues for ZFHX2 Gene

mRNA differential expression in normal tissues according to GTEx for ZFHX2 Gene

This gene is overexpressed in Testis (x6.5).

Protein differential expression in normal tissues from HIPED for ZFHX2 Gene

This gene is overexpressed in Adipocyte (62.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZFHX2 Gene



Protein tissue co-expression partners for ZFHX2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFHX2 Gene:

ZFHX2

SOURCE GeneReport for Unigene cluster for ZFHX2 Gene:

Hs.508937
genes like me logo Genes that share expression patterns with ZFHX2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZFHX2 Gene

Orthologs for ZFHX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFHX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFHX2 34 35
  • 98.97 (n)
dog
(Canis familiaris)
Mammalia ZFHX2 34 35
  • 88.59 (n)
cow
(Bos Taurus)
Mammalia ZFHX2 34 35
  • 87.26 (n)
rat
(Rattus norvegicus)
Mammalia Zfhx2 34
  • 85.98 (n)
mouse
(Mus musculus)
Mammalia Zfhx2 34 16 35
  • 85.52 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFHX2 35
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFHX2 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfhx2 34
  • 54.18 (n)
zebrafish
(Danio rerio)
Actinopterygii zfhx2 35
  • 17 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta zfh2 35
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zfh-2 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
Species where no ortholog for ZFHX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFHX2 Gene

ENSEMBL:
Gene Tree for ZFHX2 (if available)
TreeFam:
Gene Tree for ZFHX2 (if available)

Paralogs for ZFHX2 Gene

Paralogs for ZFHX2 Gene

(2) SIMAP similar genes for ZFHX2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZFHX2: view

Variants for ZFHX2 Gene

Sequence variations from dbSNP and Humsavar for ZFHX2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10142220 -- 23,521,179(+) AGGGA(C/T)TGGCA intron-variant, utr-variant-3-prime
rs10145857 -- 23,538,922(+) TAAAA(C/T)GAGAG intron-variant
rs10150025 -- 23,521,018(+) TGAAA(A/G)AACTT intron-variant, utr-variant-3-prime
rs10150401 -- 23,520,678(+) GGCTG(C/G/T)GCATA intron-variant, downstream-variant-500B
rs111239494 -- 23,554,010(+) AGTGA(C/G)CTGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZFHX2 Gene

Variant ID Type Subtype PubMed ID
nsv477115 CNV novel sequence insertion 20440878
nsv524778 CNV loss 19592680
nsv564043 CNV loss 21841781
nsv564044 CNV loss 21841781
nsv952817 CNV deletion 24416366

Variation tolerance for ZFHX2 Gene

Gene Damage Index Score: 14.86; 96.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFHX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFHX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFHX2 Gene

Disorders for ZFHX2 Gene

Relevant External Links for ZFHX2

Genetic Association Database (GAD)
ZFHX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFHX2

No disorders were found for ZFHX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFHX2 Gene

Publications for ZFHX2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 64
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZFHX2 Gene

Sources for ZFHX2 Gene

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