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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZFHX2 Gene

protein-coding GIFtS: 39
GCID: GC14M023990

Zinc Finger Homeobox 2

(Previous name: zinc finger protein 409)
(Previous symbol: ZNF409)

Search for ZFHX2
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Zinc Finger Homeobox 2¹ ²		ZFH-5²
ZNF409¹ ² ³		Zinc Finger Homeobox Protein 2²
Zinc Finger Protein 409¹ ²		KIAA1056³
Zinc Finger Homeodomain Protein 2² ³		KIAA1762³
ZFH-2² ³

External Ids:	HGNC: 20152¹	Entrez Gene: 85446²	Ensembl: ENSG00000136367⁷	UniProtKB: Q9C0A1³

Export aliases for ZFHX2 gene to outside databases

Previous GC identifers: GC14M017777 GC14M021981 GC14M021982 GC14M021983 GC14M023059

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZFHX2 Gene:

ZFHX2 (zinc finger homeobox 2) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZFHX4.

UniProtKB/Swiss-Prot: ZFHX2_HUMAN, Q9C0A1

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NT_026437.12 NC_018925.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZFHX2 gene promoter:
AP-2gamma Meis-1b GATA-2 GATA-1 YY1 HOXA5 AP-2beta AP-2alpha Meis-1 AP-2alphaA
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFHX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2

ZFHX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFHX2 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M023990: view genomic region (about GC identifiers)

Start:	23,990,064 bp from pter	End:	24,025,401 bp from pter
Size:	35,338 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZFHX2_HUMAN, Q9C0A1 (See protein sequence)

Recommended Name: Zinc finger homeobox protein 2

Size: 2572 amino acids; 274176 Da

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=BAA83008.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: Q9UPU6

Alternative splicing: 2 isoforms: Q9C0A1-1 Q9C0A1-2

Explore the universe of human proteins at neXtProt for ZFHX2: NX_Q9C0A1

Explore proteomics data for ZFHX2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9C0A1

ZFHX2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_207646.2

ENSEMBL proteins:

ENSP00000413418 ENSP00000409464 ENSP00000451342

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZFHX2 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ZFHX: Homeoboxes / ZF class

ZNF: Zinc fingers, C2H2-type

5/8 InterPro protein domains (see all 8):

IPR027028 ZFHX2

IPR015880 Znf_C2H2-like

IPR003604 Znf_U1

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR017970 Homeobox_CS

Graphical View of Domain Structure for InterPro Entry Q9C0A1

ProtoNet protein and cluster: Q9C0A1

UniProtKB/Swiss-Prot: ZFHX2_HUMAN, Q9C0A1

Similarity: Contains 13 C2H2-type zinc fingers

Similarity: Contains 3 homeobox DNA-binding domains

ZFHX2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZFHX2_HUMAN, Q9C0A1

Function: May be involved in transcriptional regulation

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0003779	actin binding	--	--
GO:0008270	zinc ion binding	IEA	--

ZFHX2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ZFHX2:

Increased gamma-H2AX phosphory

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Zfhx2):

no phenotypic analysis

ZFHX2 for phenotypes About GeneDecksing

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZFHX2

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0007010	cytoskeleton organization	--	--

ZFHX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZFHX2

Search CenterWatch for drugs/clinical trials and news about ZFHX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZFHX2 gene:

NM_033400.2

Unigene Cluster for ZFHX2:

Zinc finger homeobox 2

Hs.508937 [show with all ESTs]

Unigene Representative Sequence: NM_033400

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000419474(uc010akq.3 uc001wke.3) ENST00000606808 ENST00000412565

ENST00000555334

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Additional mRNA sequence:

AB028979.1 AB051549.1 BC144336.1 BC150606.1

6 DOTS entries:

DT.105925 DT.40310148 DT.75121693 DT.92037350 DT.91868937 DT.92424855

24/33 AceView cDNA sequences (see all 33):

BM142009 BM928251 CK819828 AB051549 AV704837 BU688647 BE393586 BM930209

AA210939 BE673662 BM141735 BX283301 CK819827 BQ889378 CF130285 AA976107

AI582864 AA535789 BM683686 AW470308 AA781938 AI216808 AI803509 BU953894

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZFHX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATGTTCCACT

About this image

See ZFHX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZFHX2

SOURCE GeneReport for Unigene cluster: Hs.508937

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZFHX2 gene from 5/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zfhx2^{1 , 5}	zinc finger homeobox 2^{1, 5}	85.94(n)¹ 85.24(a)¹		14 (28.05 cM)⁵ 239102¹ NM_001039198.1¹ NP_001034287.1¹ 55060262⁵
lizard (Anolis carolinensis)	Reptilia	ZFHX2⁶	Uncharacterized protein	53(a)	1 ↔ 1	GL343680.1(15685-29581)
zebrafish (Danio rerio)	Actinopterygii	ZFHX2⁶	zinc finger homeobox 2	12(a)	1 ↔ 1	24(14482670-14496307)
fruit fly (Drosophila melanogaster)	Insecta	zfh2⁶	Zn finger homeodomain 2	13(a)	1 → many	4(522436-560418)
worm (Caenorhabditis elegans)	Secernentea	zfh-2⁶	Protein ZFH-2	21(a)	1 → many	I(803368-834808)

ENSEMBL Gene Tree for ZFHX2 (if available)
TreeFam Gene Tree for ZFHX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZFHX2 gene

ZFHX4² ZFHX3²

2 SIMAP similar genes for ZFHX2 using alignment to 6 protein entries: ZFHX2_HUMAN (see all proteins):

POU6F1 NKX2-5

ZFHX2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations
Database of Genomic Variants (DGV) 1 variation for ZFHX2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv524778	CNV	Loss	19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZFHX2 for disorders About MalaCards

ZFHX2 for disorders About GeneDecksing

Genetic Association Database (GAD): ZFHX2

Export disorders for ZFHX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZFHX2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZFHX2)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)^{1, 2, 3} Nagase T.... Ohara O. (2000)
Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)^{1, 3} Kikuno R....Ohara O. (1999)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. (PubMed id 15161980)¹ Li T....Chock P.B. (2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)² Heilig R.... Weissenbach J. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)¹ Dias Neto E....Simpson A.J.G. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 85446	HGNC: 20152	AceView: ZFHX2	Ensembl:ENSG00000136367	euGenes: HUgn85446
ECgene: ZFHX2	H-InvDB: ZFHX2

(According to HUGE)
About This Section

HUGE: KIAA1056 KIAA1762

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZFHX2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZFHX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZFHX2 gene:
Search GeneIP for patents involving ZFHX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


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	inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFHX2
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZFHX2 gene at Home site.

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ZFHX2 Gene

Zinc Finger Homeobox 2

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ZFHX2 Gene

Zinc Finger Homeobox 2

Aliasesfor ZFHX2 gene

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Genomic Viewsfor ZFHX2 gene

Proteinsfor ZFHX2 gene

Protein Domains /Familiesfor ZFHX2 gene

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for ZFHX2 gene

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for ZFHX2 gene

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for ZFHX2 gene

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for ZFHX2 gene

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for ZFHX2 gene

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for ZFHX2 gene

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for ZFHX2 gene

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for ZFHX2 gene