Aliases for ZFHX2 Gene
Aliases for ZFHX2 Gene
External Ids for ZFHX2 Gene
- HGNC: 20152
- Entrez Gene: 85446
- Ensembl: ENSG00000136367
- UniProtKB: Q9C0A1
Previous HGNC Symbols for ZFHX2 Gene
- ZNF409
Previous GeneCards Identifiers for ZFHX2 Gene
- GC14M017777
- GC14M021981
- GC14M021982
- GC14M021983
- GC14M023059
- GC14M023990
Summaries for ZFHX2 Gene
GeneCards Summary for ZFHX2 Gene
ZFHX2 (Zinc Finger Homeobox 2) is a Protein Coding gene. Diseases associated with ZFHX2 include Marsili Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and actin binding. An important paralog of this gene is ZFHX3.
UniProtKB/Swiss-Prot for ZFHX2 Gene
-
May be involved in transcriptional regulation.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFHX2 Gene
Genomics for ZFHX2 Gene
GeneHancer (GH) Regulatory Elements for ZFHX2 Gene
Promoters and enhancers for ZFHX2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZFHX2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ZFHX2 Gene
Genomic Locations for ZFHX2 Gene
- chr14:23,520,855-23,556,192
- (GRCh38/hg38)
- Size:
- 35,338 bases
- Orientation:
- Minus strand
- chr14:23,990,064-24,025,401
- (GRCh37/hg19)
Genomic View for ZFHX2 Gene
Genes around ZFHX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q11.2 by Ensembl
- 14q11.2 by Entrez Gene
- 14q11.2 by HGNC
ZFHX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZFHX2 Gene
Proteins for ZFHX2 Gene
-
Protein details for ZFHX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9C0A1-ZFHX2_HUMAN
- Recommended name:
- Zinc finger homeobox protein 2
- Protein Accession:
- Q9C0A1
- Q9UPU6
Protein attributes for ZFHX2 Gene
- Size:
- 2572 amino acids
- Molecular mass:
- 274176 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA83008.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for ZFHX2 Gene
Post-translational modifications for ZFHX2 Gene
No Post-translational modifications
Other Protein References for ZFHX2 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ZFHX2
- Novus Biologicals Antibodies for ZFHX2
- Invitrogen Antibodies for ZFHX2
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Protein Products
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- Search GeneTex for Proteins for ZFHX2
Assay Products
No data available for DME Specific Peptides for ZFHX2 Gene
Domains & Families for ZFHX2 Gene
Gene Families for ZFHX2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZFHX2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZFHX2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ZFHX2 Gene
Function for ZFHX2 Gene
Molecular function for ZFHX2 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZFHX2 Gene
- MGI mutant phenotypes for ZFHX2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ZFHX2:
Animal Models for ZFHX2 Gene
- MGI Knock Outs for ZFHX2:
-
- Zfhx2/Zfhx2os tm2Ymri
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
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-
ViGene Biosciences ready-to-package AAV shRNAs for ZFHX2 gene
- Search ViGene Biosciences for ZFHX2
CRISPR Products
-
OriGene CRISPR knockouts for ZFHX2
- genomics-online: gRNA clones - Search results for available ZFHX2 gene related products
- Applied Biological Materials CRISPR for ZFHX2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZFHX2
- GenScript: Design CRISPR guide RNA sequences for ZFHX2
miRNA for ZFHX2 Gene
- miRTarBase miRNAs that target ZFHX2
miRNA Products
- Search ViGene Biosciences for ZFHX2
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for ZFHX2
- Browse OriGene Inhibitory RNA Products For ZFHX2
- genomics-online: shRNA clones - Search results for available ZFHX2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ZFHX2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZFHX2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZFHX2 gene related products
- orf clones - Search results for available ZFHX2 gene related products
- Applied Biological Materials Clones for ZFHX2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ZFHX2
-
ViGene Biosciences adenoviral particle packaged cDNA for ZFHX2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ZFHX2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZFHX2 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZFHX2 Gene
Localization for ZFHX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZFHX2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleoli fibrillar center (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for ZFHX2 Gene
No Data Available
Interacting Proteins for ZFHX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0030534 | adult behavior | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZFHX2 Gene
Transcripts for ZFHX2 Gene
mRNA/cDNA for ZFHX2 Gene
- (10) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (33) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZFHX2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZFHX2
- genomics-online: gRNA clones - Search results for available ZFHX2 gene related products
- Applied Biological Materials CRISPR for ZFHX2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZFHX2
- GenScript: Design CRISPR guide RNA sequences for ZFHX2
miRNA Products
- Search ViGene Biosciences for ZFHX2
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for ZFHX2
- Browse OriGene Inhibitory RNA Products For ZFHX2
- genomics-online: shRNA clones - Search results for available ZFHX2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ZFHX2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZFHX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZFHX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZFHX2 gene related products
- orf clones - Search results for available ZFHX2 gene related products
- Applied Biological Materials Clones for ZFHX2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ZFHX2 Gene
mRNA differential expression in normal tissues according to GTEx for ZFHX2 Gene
This gene is overexpressed in Testis (x6.5).
This gene is overexpressed in Adipocyte (62.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZFHX2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ZFHX2 Gene:
ZFHX2SOURCE GeneReport for Unigene cluster for ZFHX2 Gene:
Hs.508937Evidence on tissue expression from TISSUES for ZFHX2 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for ZFHX2
- genomics-online: primer clones - Search results for available ZFHX2 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFHX2 Gene
Orthologs for ZFHX2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZFHX2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ZFHX2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ZFHX2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Zfhx2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Zfhx2 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZFHX2 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ZFHX2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | zfhx2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zfhx2 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | zfh2 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | zfh-2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for ZFHX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ZFHX2 Gene
(2) SIMAP similar genes for ZFHX2 Gene using alignment to 6 proteins:
Variants for ZFHX2 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000070652 | -- | 23,521,059(-) | A/G | 3_prime_UTR_variant | |
| rs1000308389 | -- | 23,526,376(-) | C/T | coding_sequence_variant, missense_variant | |
| rs1000375875 | -- | 23,550,211(-) | T/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000420254 | -- | 23,520,965(-) | T/C | 3_prime_UTR_variant | |
| rs1000476809 | -- | 23,550,969(-) | C/T | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant |
Gene Damage Index Score:
14.86;
96.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZFHX2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZFHX2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFHX2 Gene
Disorders for ZFHX2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| marsili syndrome |
|
|
Search ZFHX2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZFHX2
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ZFHX2 Gene
Publications for ZFHX2 Gene
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 58
- Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58
- The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
Products for ZFHX2 Gene
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- Invitrogen Antibodies for ZFHX2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available ZFHX2 related products ranked by validation data
- antibodies-online: Search results for available ZFHX2 related products ranked by validation data
- antibodies-online: Search results for available ZFHX2 related products ranked by validation data
- Search GeneTex for Antibodies for ZFHX2
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- ViGene Biosciences adenoviral particle packaged cDNA for ZFHX2 gene
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Sources for ZFHX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew