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Aliases for ZFHX2 Gene

Aliases for ZFHX2 Gene

  • Zinc Finger Homeobox 2 2 3
  • Zinc Finger Homeodomain Protein 2 3 4
  • Zinc Finger Protein 409 2 3
  • ZNF409 3 4
  • ZFH-2 3 4
  • Zinc Finger Homeobox Protein 2 3
  • KIAA1056 4
  • KIAA1762 4
  • ZFH-5 3

External Ids for ZFHX2 Gene

Previous Symbols for ZFHX2 Gene

  • ZNF409

Summaries for ZFHX2 Gene

GeneCards Summary for ZFHX2 Gene

ZFHX2 (Zinc Finger Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ZFHX3.

UniProtKB/Swiss-Prot for ZFHX2 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFHX2 Gene

Genomics for ZFHX2 Gene

Genomic Location for ZFHX2 Gene

Start:
23,520,855 bp from pter
End:
23,556,192 bp from pter
Size:
35,338 bases
Orientation:
Minus strand

Genomic View for ZFHX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFHX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFHX2 Gene

Regulatory Elements for ZFHX2 Gene

Proteins for ZFHX2 Gene

  • Protein details for ZFHX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0A1-ZFHX2_HUMAN
    Recommended name:
    Zinc finger homeobox protein 2
    Protein Accession:
    Q9C0A1
    Secondary Accessions:
    • Q9UPU6

    Protein attributes for ZFHX2 Gene

    Size:
    2572 amino acids
    Molecular mass:
    274176 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA83008.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFHX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFHX2 Gene

Proteomics data for ZFHX2 Gene at MOPED

Post-translational modifications for ZFHX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFHX2 Gene

No data available for DME Specific Peptides for ZFHX2 Gene

Domains for ZFHX2 Gene

Gene Families for ZFHX2 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • ZFHX :Homeoboxes / ZF class

UniProtKB/Swiss-Prot:

ZFHX2_HUMAN
Domain:
  • Contains 3 homeobox DNA-binding domains.:
    • Q9C0A1
Similarity:
  • Contains 13 C2H2-type zinc fingers.:
    • Q9C0A1
genes like me logo Genes that share domains with ZFHX2: view

Function for ZFHX2 Gene

Molecular function for ZFHX2 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZFHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0003779 actin binding --
GO:0008270 zinc ion binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ZFHX2: view

Phenotypes for ZFHX2 Gene

MGI mutant phenotypes for ZFHX2:
inferred from 1 alleles
GenomeRNAi human phenotypes for ZFHX2:
genes like me logo Genes that share phenotypes with ZFHX2: view

miRNA for ZFHX2 Gene

miRTarBase miRNAs that target ZFHX2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFHX2 Gene

Localization for ZFHX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFHX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFHX2 Gene COMPARTMENTS Subcellular localization image for ZFHX2 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for ZFHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZFHX2: view

Pathways for ZFHX2 Gene

SuperPathways for ZFHX2 Gene

No Data Available

Interacting Proteins for ZFHX2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000413418%0d%0a9606.ENSP00000376076%0d%0a
Selected Interacting proteins: ENSP00000413418 for ZFHX2 Gene via STRING

Symbol External ID(s) Details
SUMO1

Gene Ontology (GO) - Biological Process for ZFHX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007010 cytoskeleton organization --
GO:0030534 adult behavior IEA --
genes like me logo Genes that share ontologies with ZFHX2: view

No data available for Pathways by source for ZFHX2 Gene

Transcripts for ZFHX2 Gene

Unigene Clusters for ZFHX2 Gene

Zinc finger homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFHX2 Gene

No ASD Table

Relevant External Links for ZFHX2 Gene

GeneLoc Exon Structure for
ZFHX2
ECgene alternative splicing isoforms for
ZFHX2

Expression for ZFHX2 Gene

mRNA expression in normal human tissues for ZFHX2 Gene

mRNA differential expression in normal tissues according to GTEx for ZFHX2 Gene

This gene is overexpressed in Testis (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZFHX2 Gene

SOURCE GeneReport for Unigene cluster for ZFHX2 Gene Hs.508937

genes like me logo Genes that share expressions with ZFHX2: view

Orthologs for ZFHX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFHX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFHX2 36
  • 98.97 (n)
  • 98.4 (a)
ZFHX2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFHX2 36
  • 87.26 (n)
  • 86.94 (a)
ZFHX2 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFHX2 36
  • 88.59 (n)
  • 88 (a)
ZFHX2 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfhx2 36
  • 85.52 (n)
  • 84.51 (a)
Zfhx2 16
Zfhx2 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFHX2 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfhx2 36
  • 85.98 (n)
  • 84.65 (a)
lizard
(Anolis carolinensis)
Reptilia ZFHX2 37
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfhx2 36
  • 54.18 (n)
  • 50.5 (a)
zebrafish
(Danio rerio)
Actinopterygii zfhx2 37
  • 17 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta zfh2 37
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zfh-2 37
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 24 (a)
ManyToMany
-- 37
  • 30 (a)
ManyToMany
Species with no ortholog for ZFHX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFHX2 Gene

ENSEMBL:
Gene Tree for ZFHX2 (if available)
TreeFam:
Gene Tree for ZFHX2 (if available)

Paralogs for ZFHX2 Gene

Paralogs for ZFHX2 Gene

Selected SIMAP similar genes for ZFHX2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZFHX2: view

Variants for ZFHX2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZFHX2 Gene

Variant ID Type Subtype PubMed ID
nsv524778 CNV Loss 19592680

Relevant External Links for ZFHX2 Gene

HapMap Linkage Disequilibrium report
ZFHX2

No data available for Sequence variations from dbSNP and Humsavar for ZFHX2 Gene

Disorders for ZFHX2 Gene

Relevant External Links for ZFHX2

Genetic Association Database (GAD)
ZFHX2
genes like me logo Genes that share disorders with ZFHX2: view

No data available for UniProtKB/Swiss-Prot for ZFHX2 Gene

Publications for ZFHX2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3
  3. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. (PMID: 15161980) Li T. … Chock P.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3

Products for ZFHX2 Gene

Sources for ZFHX2 Gene

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