ZFHX2 Gene
protein-coding GIFtS: 38
GCID: GC14M023990
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zinc finger homeobox 2(Previous name: zinc finger protein 409 )
(Previous symbol: ZNF409)
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Aliases
for ZFHX2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Homeobox 21 2 | | KIAA17621 3 | | ZNF4091 2 3 | | Zinc Finger Homeodomain Protein 22 3 | | ZFH-51 2 | | ZFH-22 3 | | Zinc Finger Protein 4091 2 | | Zinc Finger Homeobox Protein 22 | | KIAA10561 3 | | |
Export aliases for ZFHX2 gene to outside databasesPrevious GC identifers: GC14M017777 GC14M021981 GC14M021982 GC14M021983 GC14M023059 |
Summaries
for ZFHX2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZFHX2_HUMAN, Q9C0A1Function: May be involved in transcriptional regulation
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Genomic Views
for ZFHX2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZFHX2 gene promoter:
AP-2gamma Meis-1b GATA-2 GATA-1 YY1 HOXA5 AP-2beta AP-2alpha Meis-1 AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZFHX2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFHX2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2ZFHX2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M023990: view genomic region
(about GC identifiers)
Start:
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23,990,069 bp from pter |
End:
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24,025,401 bp from pter |
Size:
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35,333 bases |
Orientation:
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minus strand |
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Proteins
for ZFHX2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZFHX2_HUMAN, Q9C0A1 (See
protein sequence)Recommended Name: Zinc finger homeobox protein 2 Size: 2572 amino acids; 274176 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA83008.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q9UPU6Alternative splicing: 2 isoforms: Q9C0A1-1 Q9C0A1-2 Explore the universe of human proteins at neXtProt for ZFHX2: NX_Q9C0A1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9C0A1
ZFHX2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_207646.2
ENSEMBL proteins: ENSP00000453053 ENSP00000413418 ENSP00000451342 ENSP00000409464
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZFHX2 for ontologies About GeneDecksing
ZFHX2 Antibody Products:
Assay Products for ZFHX2: |
Protein
Domains /
Families
for ZFHX2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZFHX2 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9C0A1ProtoNet protein and cluster: Q9C0A1 UniProtKB/Swiss-Prot: ZFHX2_HUMAN, Q9C0A1Similarity: Contains 13 C2H2-type zinc fingersSimilarity: Contains 3 homeobox DNA-binding domains |
Function
for ZFHX2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZFHX2_HUMAN, Q9C0A1Function: May be involved in transcriptional regulation
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFHX2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
-- | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
ZFHX2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZFHX2:
Animal Models:
Mouse knock-out Zfhx2/Zfhx2asZfhx2/tm1Ymri for ZFHX2
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Zfhx2):
ZFHX2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ZFHX2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFHX2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- |
ZFHX2 for ontologies About GeneDecksing
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Drugs & Compounds
for ZFHX2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZFHX2
Search CenterWatch for drugs/clinical trials and news about ZFHX2 
|
Transcripts
for ZFHX2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZFHX2 gene: NM_033400.2 Unigene Cluster for ZFHX2: Zinc finger homeobox 2 Hs.508937 [show with all ESTs]Unigene Representative Sequence: NM_0334004 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000560206(uc010tno.2) ENST00000419474(uc010akq.3 uc001wke.3)
ENST00000555334 ENST00000412565
Additional cDNA sequence: AB028979.1 AB051549.1 BC144336.1 BC150606.1 6 DOTS entries: DT.105925 DT.40310148 DT.75121693 DT.92037350 DT.91868937 DT.92424855 24/33 AceView cDNA sequences (see all 33): AB051549 BM928251 BM142009 CK819828 BM930209 BM141735 BE673662 BU688647 CK819827 BE393586 AA210939 BX283301 AV704837 BQ889378 AW470308 AA976107 BU953894 AI582864 BM683686 AI216808 AA535789 AI093184 CF130285 AI803509
GeneLoc Exon Structure
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Expression
for ZFHX2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZFHX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGTTCCACT
About this image
See ZFHX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZFHX2
SOURCE GeneReport for Unigene cluster: Hs.508937
SABiosciences Custom PCR Arrays for ZFHX2
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFHX2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZFHX2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFHX2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFHX2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFHX2 |
Orthologs
for ZFHX2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for ZFHX2 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
ZFHX26 |
-- |
52(a) |
1 ↔ 1 |
GL343680.1(15685-29581) |
zebrafish
(Danio rerio) |
Actinopterygii |
wu:fa03a116 |
wu:fa03a11 |
13(a) |
possible ortholog |
24(14482670-14496307) |
fruit fly
(Drosophila melanogaster) |
Insecta |
zfh26 |
Zn finger homeodomain 2 |
14(a) |
1 → many |
4(522436-560418) |
worm
(Caenorhabditis elegans) |
Secernentea |
zfh-26 |
Protein ZFH-2 |
21(a) |
1 → many |
I(803371-834811) |
ENSEMBL Gene Tree for ZFHX2 (if available)
TreeFam Gene Tree for ZFHX2 (if available) |
Paralogs
for ZFHX2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZFHX2 gene
- ZFHX42 ZFHX32
3 SIMAP similar genes for ZFHX2 using alignment to 7 protein entries: ZFHX2_HUMAN (see all proteins):POU6F1 NKX2-5 DUX2
ZFHX2 for paralogs About GeneDecksing
|
Genomic Variants
for ZFHX2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFHX2 |
|
Disorders
/ Diseases
for ZFHX2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZFHX2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZFHX2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZFHX2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 3 Kikuno R....Ohara O. (1999)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. (PubMed id 15161980)1 Li T....Chock P.B. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
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External Searches for ZFHX2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ZFHX2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing ZFHX2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZFHX2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZFHX2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ZFHX2 gene:
Search GeneIP for patents involving ZFHX2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZFHX2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZFHX2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFHX2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFHX2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | Browse 3'-UTR reporter clones for miRNA target validation | | | Browse OriGene untagged cDNA clones in CMV expression vector | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFHX2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZFHX2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFHX2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFHX2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFHX2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFHX2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFHX2 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZFHX2 |
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 | | | ZFHX2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFHX2 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZFHX2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFHX2 |
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