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Aliases for ZFC3H1 Gene

Aliases for ZFC3H1 Gene

  • Zinc Finger C3H1-Type Containing 2 3 5
  • Coiled-Coil Domain-Containing Protein 131 3 4
  • Proline/Serine-Rich Coiled-Coil Protein 2 3 4
  • Proline/Serine-Rich Coiled-Coil 2 2 3
  • Coiled-Coil Domain Containing 131 2 3
  • CCDC131 3 4
  • PSRC2 3 4
  • Zinc Finger C3H1 Domain-Containing Protein 3
  • KIAA0546 4
  • CSRC2 3

External Ids for ZFC3H1 Gene

Previous HGNC Symbols for ZFC3H1 Gene

  • PSRC2
  • CCDC131

Previous GeneCards Identifiers for ZFC3H1 Gene

  • GC12M070292
  • GC12M072003
  • GC12M069052

Summaries for ZFC3H1 Gene

GeneCards Summary for ZFC3H1 Gene

ZFC3H1 (Zinc Finger C3H1-Type Containing) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFC3H1 Gene

Genomics for ZFC3H1 Gene

Regulatory Elements for ZFC3H1 Gene

Enhancers for ZFC3H1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G071625 1.2 ENCODE dbSUPER 15.7 +40.8 40805 1.9 HDAC1 INSM2 FEZF1 ZBTB40 TCF12 ZNF366 ZSCAN5C FOS ZNF391 IKZF2 ZFC3H1 THAP2 ENSG00000257515 GC12P071640 ENSG00000257761
GH12G071731 1.3 FANTOM5 Ensembl ENCODE 11.6 -64.2 -64246 1.0 ELF3 DRAP1 CTCF SAP130 RAD21 GATAD1 ZSCAN29 ZNF600 HOMEZ MIXL1 TMEM19 ZFC3H1 ENSG00000257515 RAB21
GH12G071638 0.7 dbSUPER 17 +28.2 28189 2.2 CTCF NR2F1 MAFG REST RAD21 ZNF316 MAFF SMC3 NR2F6 MAFK ZFC3H1 THAP2 ENSG00000257515 LGR5 ENSG00000212461
GH12G071693 1 Ensembl ENCODE 11.6 -26.7 -26704 2.0 MTA2 CBFB NR2F1 HLF WRNIP1 SIN3A TBX21 ZBTB40 CBX5 POLR2A ZFC3H1 ENSG00000257515 TMEM19
GH12G071753 0.9 FANTOM5 11.2 -85.4 -85408 0.1 HDAC1 ATF1 TBL1XR1 ARNT CHAMP1 TCF12 ZNF766 GATA2 BCLAF1 CREM TMEM19 ZFC3H1 THAP2 ENSG00000212461 RAB21 ENSG00000257515
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFC3H1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZFC3H1 Gene

Chromosome:
12
Start:
71,609,472 bp from pter
End:
71,667,725 bp from pter
Size:
58,254 bases
Orientation:
Minus strand

Genomic View for ZFC3H1 Gene

Genes around ZFC3H1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFC3H1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFC3H1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFC3H1 Gene

Proteins for ZFC3H1 Gene

  • Protein details for ZFC3H1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60293-ZC3H1_HUMAN
    Recommended name:
    Zinc finger C3H1 domain-containing protein
    Protein Accession:
    O60293
    Secondary Accessions:
    • Q6GMU1
    • Q6P2S9
    • Q6ZV36
    • Q96BE7

    Protein attributes for ZFC3H1 Gene

    Size:
    1989 amino acids
    Molecular mass:
    226356 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25472.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86028.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFC3H1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFC3H1 Gene

Post-translational modifications for ZFC3H1 Gene

  • Ubiquitination at isoforms=2880
  • Modification sites at PhosphoSitePlus

Other Protein References for ZFC3H1 Gene

No data available for DME Specific Peptides for ZFC3H1 Gene

Domains & Families for ZFC3H1 Gene

Gene Families for ZFC3H1 Gene

Suggested Antigen Peptide Sequences for ZFC3H1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZFC3H1: view

No data available for UniProtKB/Swiss-Prot for ZFC3H1 Gene

Function for ZFC3H1 Gene

Gene Ontology (GO) - Molecular Function for ZFC3H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 20195357
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFC3H1: view
genes like me logo Genes that share phenotypes with ZFC3H1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFC3H1 Gene

Localization for ZFC3H1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFC3H1 gene
Compartment Confidence
extracellular 5
nucleus 4
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ZFC3H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
genes like me logo Genes that share ontologies with ZFC3H1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZFC3H1 Gene

Pathways & Interactions for ZFC3H1 Gene

SuperPathways for ZFC3H1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFC3H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with ZFC3H1: view

No data available for Pathways by source and SIGNOR curated interactions for ZFC3H1 Gene

Drugs & Compounds for ZFC3H1 Gene

No Compound Related Data Available

Transcripts for ZFC3H1 Gene

Unigene Clusters for ZFC3H1 Gene

Zinc finger, C3H1-type containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFC3H1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^
SP1: -
SP2: -
SP3:
SP4:
SP5: - - - -
SP6: - - -
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31a · 31b ^ 32 ^ 33a · 33b · 33c ^ 34a · 34b · 34c ^ 35a · 35b ^ 36 ^
SP1: - - - - -
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 37a · 37b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ZFC3H1 Gene

GeneLoc Exon Structure for
ZFC3H1
ECgene alternative splicing isoforms for
ZFC3H1

Expression for ZFC3H1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFC3H1 Gene

Protein differential expression in normal tissues from HIPED for ZFC3H1 Gene

This gene is overexpressed in Pancreatic juice (27.7) and Lung (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFC3H1 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZFC3H1 Gene:

ZFC3H1

SOURCE GeneReport for Unigene cluster for ZFC3H1 Gene:

Hs.527874

Evidence on tissue expression from TISSUES for ZFC3H1 Gene

  • Nervous system(4.3)
  • Liver(4.2)
  • Blood(4.1)
  • Pancreas(2.6)
genes like me logo Genes that share expression patterns with ZFC3H1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFC3H1 Gene

Orthologs for ZFC3H1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFC3H1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFC3H1 34 35
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia ZFC3H1 34 35
  • 93.65 (n)
dog
(Canis familiaris)
Mammalia ZFC3H1 34 35
  • 93.04 (n)
rat
(Rattus norvegicus)
Mammalia Zfc3h1 34
  • 88.97 (n)
mouse
(Mus musculus)
Mammalia Zfc3h1 34 16 35
  • 88.78 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFC3H1 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFC3H1 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFC3H1 34 35
  • 74.8 (n)
lizard
(Anolis carolinensis)
Reptilia ZFC3H1 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfc3h1 34
  • 64.83 (n)
Str.235 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15668 34
zebrafish
(Danio rerio)
Actinopterygii ZFC3H1 35
  • 28 (a)
OneToOne
Species where no ortholog for ZFC3H1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFC3H1 Gene

ENSEMBL:
Gene Tree for ZFC3H1 (if available)
TreeFam:
Gene Tree for ZFC3H1 (if available)

Paralogs for ZFC3H1 Gene

No data available for Paralogs for ZFC3H1 Gene

Variants for ZFC3H1 Gene

Sequence variations from dbSNP and Humsavar for ZFC3H1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000002241 -- 71,645,514(+) AGTAA(C/T)AGAGA intron-variant
rs1000034723 -- 71,645,170(+) TGAAG(C/T)GTGAA intron-variant
rs1000047184 -- 71,629,814(+) TTATA(C/T)GGTAC intron-variant
rs1000055415 -- 71,640,194(+) TTTTT(C/G)TATTT intron-variant
rs1000066041 -- 71,619,477(+) GGGAG(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFC3H1 Gene

Variant ID Type Subtype PubMed ID
nsv832451 CNV loss 17160897

Variation tolerance for ZFC3H1 Gene

Residual Variation Intolerance Score: 1.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFC3H1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFC3H1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFC3H1 Gene

Disorders for ZFC3H1 Gene

Relevant External Links for ZFC3H1

Genetic Association Database (GAD)
ZFC3H1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFC3H1

No disorders were found for ZFC3H1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFC3H1 Gene

Publications for ZFC3H1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3 64
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3 64

Products for ZFC3H1 Gene

Sources for ZFC3H1 Gene

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