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Aliases for ZFC3H1 Gene

Aliases for ZFC3H1 Gene

  • Zinc Finger C3H1-Type Containing 2 3
  • Coiled-Coil Domain-Containing Protein 131 3 4
  • Proline/Serine-Rich Coiled-Coil Protein 2 3 4
  • Proline/Serine-Rich Coiled-Coil 2 2 3
  • Coiled-Coil Domain Containing 131 2 3
  • Zinc Finger, C3H1-Type Containing 3 5
  • CCDC131 3 4
  • PSRC2 3 4
  • KIAA0546 4
  • CSRC2 3

External Ids for ZFC3H1 Gene

Previous HGNC Symbols for ZFC3H1 Gene

  • PSRC2
  • CCDC131

Previous GeneCards Identifiers for ZFC3H1 Gene

  • GC12M070292
  • GC12M072003
  • GC12M069052

Summaries for ZFC3H1 Gene

GeneCards Summary for ZFC3H1 Gene

ZFC3H1 (Zinc Finger C3H1-Type Containing) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFC3H1 Gene

Genomics for ZFC3H1 Gene

Regulatory Elements for ZFC3H1 Gene

Genomic Location for ZFC3H1 Gene

Chromosome:
12
Start:
71,609,472 bp from pter
End:
71,667,725 bp from pter
Size:
58,254 bases
Orientation:
Minus strand

Genomic View for ZFC3H1 Gene

Genes around ZFC3H1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFC3H1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFC3H1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFC3H1 Gene

Proteins for ZFC3H1 Gene

  • Protein details for ZFC3H1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60293-ZC3H1_HUMAN
    Recommended name:
    Zinc finger C3H1 domain-containing protein
    Protein Accession:
    O60293
    Secondary Accessions:
    • Q6GMU1
    • Q6P2S9
    • Q6ZV36
    • Q96BE7

    Protein attributes for ZFC3H1 Gene

    Size:
    1989 amino acids
    Molecular mass:
    226356 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25472.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86028.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFC3H1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFC3H1 Gene

Proteomics data for ZFC3H1 Gene at MOPED

Post-translational modifications for ZFC3H1 Gene

  • Ubiquitination at Lys 880
  • Modification sites at PhosphoSitePlus

Other Protein References for ZFC3H1 Gene

No data available for DME Specific Peptides for ZFC3H1 Gene

Domains & Families for ZFC3H1 Gene

Gene Families for ZFC3H1 Gene

Suggested Antigen Peptide Sequences for ZFC3H1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60293

UniProtKB/Swiss-Prot:

ZC3H1_HUMAN :
  • Contains 1 C3H1-type zinc finger.
Similarity:
  • Contains 1 C3H1-type zinc finger.
  • Contains 7 TPR repeats.
genes like me logo Genes that share domains with ZFC3H1: view

Function for ZFC3H1 Gene

Gene Ontology (GO) - Molecular Function for ZFC3H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with ZFC3H1: view
genes like me logo Genes that share phenotypes with ZFC3H1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFC3H1 Gene

Localization for ZFC3H1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFC3H1 Gene COMPARTMENTS Subcellular localization image for ZFC3H1 gene
Compartment Confidence
extracellular 5
nucleus 4
cytoskeleton 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZFC3H1 Gene

Pathways & Interactions for ZFC3H1 Gene

SuperPathways for ZFC3H1 Gene

No Data Available

Interacting Proteins for ZFC3H1 Gene

Gene Ontology (GO) - Biological Process for ZFC3H1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZFC3H1 Gene

Drugs & Compounds for ZFC3H1 Gene

No Compound Related Data Available

Transcripts for ZFC3H1 Gene

Unigene Clusters for ZFC3H1 Gene

Zinc finger, C3H1-type containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFC3H1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^
SP1: -
SP2: -
SP3:
SP4:
SP5: - - - -
SP6: - - -
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31a · 31b ^ 32 ^ 33a · 33b · 33c ^ 34a · 34b · 34c ^ 35a · 35b ^ 36 ^
SP1: - - - - -
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 37a · 37b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ZFC3H1 Gene

GeneLoc Exon Structure for
ZFC3H1
ECgene alternative splicing isoforms for
ZFC3H1

Expression for ZFC3H1 Gene

mRNA expression in normal human tissues for ZFC3H1 Gene

Protein differential expression in normal tissues from HIPED for ZFC3H1 Gene

This gene is overexpressed in Pancreatic juice (27.7) and Lung (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFC3H1 Gene



SOURCE GeneReport for Unigene cluster for ZFC3H1 Gene Hs.527874

genes like me logo Genes that share expression patterns with ZFC3H1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZFC3H1 Gene

Orthologs for ZFC3H1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFC3H1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZFC3H1 35
  • 93.65 (n)
  • 94.57 (a)
ZFC3H1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFC3H1 35
  • 93.04 (n)
  • 94.95 (a)
ZFC3H1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfc3h1 35
  • 88.78 (n)
  • 91.58 (a)
Zfc3h1 16
Zfc3h1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZFC3H1 35
  • 99.77 (n)
  • 99.85 (a)
ZFC3H1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfc3h1 35
  • 88.97 (n)
  • 91.74 (a)
oppossum
(Monodelphis domestica)
Mammalia ZFC3H1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFC3H1 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFC3H1 35
  • 74.8 (n)
  • 73.97 (a)
ZFC3H1 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFC3H1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.235 35
zfc3h1 35
  • 64.83 (n)
  • 60.06 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15668 35
zebrafish
(Danio rerio)
Actinopterygii ZFC3H1 36
  • 28 (a)
OneToOne
Species with no ortholog for ZFC3H1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFC3H1 Gene

ENSEMBL:
Gene Tree for ZFC3H1 (if available)
TreeFam:
Gene Tree for ZFC3H1 (if available)

Paralogs for ZFC3H1 Gene

No data available for Paralogs for ZFC3H1 Gene

Variants for ZFC3H1 Gene

Sequence variations from dbSNP and Humsavar for ZFC3H1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1011332 - 71,632,316(-) AACCC(A/G)AATTT reference, missense
rs11541286 - 71,614,641(-) ATTCA(A/C/G)ATTTT reference, missense
rs724211 -- 71,641,830(+) GAGTA(A/G)TGTTC intron-variant
rs1280594 -- 71,629,455(+) AGCCA(C/G)CGCAC intron-variant
rs1280595 -- 71,629,947(+) TGAAC(A/T)AAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFC3H1 Gene

Variant ID Type Subtype PubMed ID
nsv832451 CNV Loss 17160897

Variation tolerance for ZFC3H1 Gene

Residual Variation Intolerance Score: 1.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFC3H1 Gene

HapMap Linkage Disequilibrium report
ZFC3H1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFC3H1 Gene

Disorders for ZFC3H1 Gene

Relevant External Links for ZFC3H1

Genetic Association Database (GAD)
ZFC3H1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFC3H1

No disorders were found for ZFC3H1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFC3H1 Gene

Publications for ZFC3H1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  5. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for ZFC3H1 Gene

Sources for ZFC3H1 Gene

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