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Aliases for ZFAT Gene

Aliases for ZFAT Gene

  • Zinc Finger And AT Hook Domain Containing 2 3
  • Zinc Finger Protein 406 2 3 4
  • ZNF406 3 4 6
  • ZFAT1 3 4 6
  • AITD3 3 6
  • Zinc Finger Gene In Autoimmune Thyroid Disease 3
  • Zinc-Finger Gene In AITD Susceptibility Region 3
  • Zinc Finger Gene In AITD Susceptibility Region 4
  • Zinc Finger Protein ZFAT 3
  • KIAA1485 4

External Ids for ZFAT Gene

Previous Symbols for ZFAT Gene

  • ZNF406
  • ZFAT1

Summaries for ZFAT Gene

Entrez Gene Summary for ZFAT Gene

  • This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]

GeneCards Summary for ZFAT Gene

ZFAT (Zinc Finger And AT Hook Domain Containing) is a Protein Coding gene. Diseases associated with ZFAT include autoimmune thyroid disease 3 and croup. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription.

UniProtKB/Swiss-Prot for ZFAT Gene

  • May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAT Gene

Genomics for ZFAT Gene

Genomic Location for ZFAT Gene

Start:
134,477,788 bp from pter
End:
134,713,049 bp from pter
Size:
235,262 bases
Orientation:
Minus strand

Genomic View for ZFAT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAT Gene

Regulatory Elements for ZFAT Gene

Proteins for ZFAT Gene

  • Protein details for ZFAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P243-ZFAT_HUMAN
    Recommended name:
    Zinc finger protein ZFAT
    Protein Accession:
    Q9P243
    Secondary Accessions:
    • B7ZL15
    • E9PER3
    • Q3MIM5
    • Q6PJ01
    • Q75PJ6
    • Q75PJ7
    • Q75PJ9
    • Q86X64

    Protein attributes for ZFAT Gene

    Size:
    1243 amino acids
    Molecular mass:
    139034 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZFAT Gene

    Alternative splice isoforms for ZFAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFAT Gene

Proteomics data for ZFAT Gene at MOPED

Post-translational modifications for ZFAT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFAT Gene

Domains for ZFAT Gene

Gene Families for ZFAT Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZFAT Gene

Suggested Antigen Peptide Sequences for ZFAT Gene

Graphical View of Domain Structure for InterPro Entry

Q9P243

UniProtKB/Swiss-Prot:

ZFAT_HUMAN
Similarity:
  • Contains 19 C2H2-type zinc fingers.:
    • Q9P243
genes like me logo Genes that share domains with ZFAT: view

Function for ZFAT Gene

Molecular function for ZFAT Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity).

Gene Ontology (GO) - Molecular Function for ZFAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFAT: view
genes like me logo Genes that share phenotypes with ZFAT: view

Animal Models for ZFAT Gene

MGI Knock Outs for ZFAT:

miRNA for ZFAT Gene

miRTarBase miRNAs that target ZFAT

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZFAT Gene

Localization for ZFAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFAT Gene

Nucleus. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFAT Gene COMPARTMENTS Subcellular localization image for ZFAT gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZFAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with ZFAT: view

Pathways for ZFAT Gene

SuperPathways for ZFAT Gene

No Data Available

Interacting Proteins for ZFAT Gene

Gene Ontology (GO) - Biological Process for ZFAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0030097 hemopoiesis --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:0060712 spongiotrophoblast layer development IEA --
genes like me logo Genes that share ontologies with ZFAT: view

No data available for Pathways by source for ZFAT Gene

Transcripts for ZFAT Gene

Unigene Clusters for ZFAT Gene

Zinc finger and AT hook domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAT Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - -
SP6: -
SP7: - - - -
SP8:

Relevant External Links for ZFAT Gene

GeneLoc Exon Structure for
ZFAT
ECgene alternative splicing isoforms for
ZFAT

Expression for ZFAT Gene

mRNA expression in normal human tissues for ZFAT Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFAT Gene

SOURCE GeneReport for Unigene cluster for ZFAT Gene Hs.446172

mRNA Expression by UniProt/SwissProt for ZFAT Gene

Q9P243-ZFAT_HUMAN
Tissue specificity: Isoform 1 is strongly expressed in placenta, spleen, kidney, testis and peripheral blood leukocytes. Expressed in CD4+ and CD8+ T-cells, CD19+ B-cells and CB14+ monocytes. Isoform 3 is strongly expressed in placenta, ovary, tonsil, CD19+ B-cells and CD14+ monocytes.
genes like me logo Genes that share expressions with ZFAT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZFAT Gene

Orthologs for ZFAT Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFAT 35
  • 99.54 (n)
  • 99.4 (a)
ZFAT 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFAT 35
  • 85.1 (n)
  • 86.29 (a)
ZFAT 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFAT 35
  • 85.85 (n)
  • 87.52 (a)
ZFAT 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfat 35
  • 85.9 (n)
  • 88.75 (a)
Zfat 16
Zfat 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFAT 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFAT 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfat 35
  • 85.47 (n)
  • 88.75 (a)
chicken
(Gallus gallus)
Aves ZFAT 35
  • 71.24 (n)
  • 75.08 (a)
ZFAT 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFAT 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17491 35
zfat 35
  • 66.92 (n)
  • 67.32 (a)
zebrafish
(Danio rerio)
Actinopterygii zfat 35
  • 64.54 (n)
  • 63.81 (a)
zfat 36
  • 60 (a)
OneToOne
Species with no ortholog for ZFAT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFAT Gene

ENSEMBL:
Gene Tree for ZFAT (if available)
TreeFam:
Gene Tree for ZFAT (if available)

Paralogs for ZFAT Gene

genes like me logo Genes that share paralogs with ZFAT: view

No data available for Paralogs for ZFAT Gene

Variants for ZFAT Gene

Sequence variations from dbSNP and Humsavar for ZFAT Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2376 -- 134,682,999(-) GTCCA(G/T)TTCTC intron-variant
rs716100 -- 134,649,035(-) atgac(C/T)atgtg intron-variant
rs721000 -- 134,561,953(-) GTAAC(A/G)TATTT intron-variant
rs721001 -- 134,561,883(-) CCCCC(C/G)ACTTT intron-variant
rs723696 -- 134,554,662(-) ATTAG(A/G)CATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFAT Gene

Variant ID Type Subtype PubMed ID
esv2660261 CNV Deletion 23128226
esv25822 CNV Gain+Loss 19812545
esv25625 CNV Loss 19812545
nsv820465 CNV Deletion 20802225
esv2737626 CNV Deletion 23290073
esv2737627 CNV Deletion 23290073
esv1297525 CNV Deletion 17803354
esv2737628 CNV Deletion 23290073
esv2737630 CNV Deletion 23290073
nsv891460 CNV Gain 21882294
dgv7876n71 CNV Gain 21882294
dgv7877n71 CNV Gain 21882294
nsv891464 CNV Gain 21882294
nsv525439 CNV Loss 19592680
nsv891469 CNV Gain 21882294
nsv397081 CNV Loss 16902084

Relevant External Links for ZFAT Gene

HapMap Linkage Disequilibrium report
ZFAT
Human Gene Mutation Database (HGMD)
ZFAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAT Gene

Disorders for ZFAT Gene

(1) OMIM Diseases for ZFAT Gene (610931)

(1) University of Copenhagen DISEASES for ZFAT Gene

Relevant External Links for ZFAT

Genetic Association Database (GAD)
ZFAT
Human Genome Epidemiology (HuGE) Navigator
ZFAT
genes like me logo Genes that share disorders with ZFAT: view

No data available for UniProtKB/Swiss-Prot for ZFAT Gene

Publications for ZFAT Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. SNPs in the promoter of a B cell-specific antisense transcript, SAS- ZFAT, determine susceptibility to autoimmune thyroid disease. (PMID: 15294872) Shirasawa S. … Sasazuki T. (Hum. Mol. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. ZFAT expression in B and T lymphocytes and identification of ZFAT-regulated genes. (PMID: 18329245) Koyanagi M. … Shirasawa S. (Genomics 2008) 2 3
  5. Detecting rare variants for complex traits using family and unrelated data. (PMID: 19847924) Zhu X. … Elston R.C. (Genet. Epidemiol. 2010) 3 48

Products for ZFAT Gene

Sources for ZFAT Gene

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