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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFAT Gene

protein-coding   GIFtS: 52
GCID: GC08M135561

Zinc Finger And AT Hook Domain Containing

(Previous name: zinc finger protein 406)
(Previous symbols: ZNF406, ZFAT1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger And AT Hook Domain Containing1 2     Zinc Finger Gene In Autoimmune Thyroid Disease2
ZFAT11 2 3 5     Zinc Finger Protein ZFAT2
ZNF4061 2 3 5     Zinc-Finger Gene In AITD Susceptibility Region2
Zinc Finger Protein 4061 2 3     KIAA14853
AITD32 5     Zinc Finger Gene In AITD Susceptibility Region3

External Ids:    HGNC: 198991   Entrez Gene: 576232   Ensembl: ENSG000000668277   OMIM: 6109315   UniProtKB: Q9P2433   

Export aliases for ZFAT gene to outside databases

Previous GC identifer: GC08M130805


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZFAT Gene:
This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in
apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on
chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
(provided by RefSeq, Nov 2009)

GeneCards Summary for ZFAT Gene: 
ZFAT (zinc finger and AT hook domain containing) is a protein-coding gene. Diseases associated with ZFAT include autoimmune thyroiditis, and childhood type dermatomyositis. GO annotations related to this gene include DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription.

UniProtKB/Swiss-Prot: ZFAT_HUMAN, Q9P243
Function: May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of
genes involved in the immune response. Some genes are also up-regulated (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFAT gene promoter:
         Max   NRF-2   Zic1   p300   Evi-1   c-Myc   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZFAT promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFAT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFAT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.22   Ensembl cytogenetic band:  8q24.22   HGNC cytogenetic band: 8q24.23

ZFAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFAT gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M135561:  view genomic region     (about GC identifiers)

Start:
135,490,031 bp from pter      End:
135,725,292 bp from pter
Size:
235,262 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZFAT_HUMAN, Q9P243 (See protein sequence)
Recommended Name: Zinc finger protein ZFAT  
Size: 1243 amino acids; 139034 Da
Subcellular location: Nucleus (By similarity). Cytoplasm, cytosol (By similarity)
6/13 PDB 3D structures from and Proteopedia for ZFAT (see all 13):
2ELM (3D)        2ELN (3D)        2ELO (3D)        2ELP (3D)        2ELQ (3D)        2ELR (3D)    
Secondary accessions: B7ZL15 E9PER3 Q3MIM5 Q6PJ01 Q75PJ6 Q75PJ7 Q75PJ9 Q86X64
Alternative splicing: 4 isoforms:  Q9P243-1   Q9P243-2   Q9P243-3   Q9P243-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFAT: NX_Q9P243

Explore proteomics data for ZFAT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P243

  • ZFAT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFAT Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001025110.2  NP_001161055.1  NP_001167628.1  NP_001167629.1  NP_065914.2  

    ENSEMBL proteins: 
     ENSP00000427879   ENSP00000427831   ENSP00000394501   ENSP00000367069   ENSP00000429050  
     ENSP00000429930   ENSP00000428483   ENSP00000429600   ENSP00000429091   ENSP00000430924  
     ENSP00000429983   ENSP00000428192  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol IEA--

    ZFAT for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9P243

    ProtoNet protein and cluster: Q9P243

    UniProtKB/Swiss-Prot: ZFAT_HUMAN, Q9P243
    Similarity: Contains 19 C2H2-type zinc fingers


    ZFAT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFAT_HUMAN, Q9P243
    Function: May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of
    genes involved in the immune response. Some genes are also up-regulated (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZFAT for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zfat):
     cellular  embryogenesis  hematopoietic system  immune system  mortality/aging 

    ZFAT for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zfattm1Sawa for ZFAT

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFAT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZFAT

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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFAT

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZFAT (ENSP000003670694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YY1AP1ENSP000002955664STRING: ENSP00000295566
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002244hematopoietic progenitor cell differentiation IEA--
    GO:0030097hemopoiesis ----
    GO:0060712spongiotrophoblast layer development IEA--

    ZFAT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFAT

    Search CenterWatch for drugs/clinical trials and news about ZFAT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFAT gene (5 alternative transcripts): 
    NM_001029939.3  NM_001167583.2  NM_001174157.1  NM_001174158.1  NM_020863.3  

    Unigene Cluster for ZFAT:

    Zinc finger and AT hook domain containing
    Hs.446172  [show with all ESTs]
    Unigene Representative Sequence: AL832066
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520356(uc010meh.3) ENST00000520727(uc003yun.3 uc003yuo.3)
    ENST00000429442 ENST00000377838 ENST00000523924(uc003yuq.3) ENST00000523243(uc003yup.3 uc010mej.3 uc010mei.3)
    ENST00000518408(uc011ljj.2) ENST00000520214 ENST00000521673 ENST00000523399
    ENST00000522723 ENST00000517307 ENST00000519827 ENST00000522974(uc003yur.3)
    ENST00000523040 ENST00000522257 ENST00000518191
    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFAT:
    hsa-miR-3650 hsa-miR-138 hsa-miR-4299 hsa-miR-626
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): ZFAT 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB040918.1 AB167738.1 AB167739.1 AB167740.1 AK094089.1 AK300133.1 AK300324.1 AK300471.1 
    AK301413.1 AK311494.1 AL832066.1 BC012989.2 BC025423.2 BC039059.1 BC046180.1 BC070097.1 
    BC098405.1 BC101766.1 BC101768.1 BC143519.1 

    14 DOTS entries:

    DT.95179137  DT.212773  DT.102822436  DT.92017723  DT.100024703  DT.100808007  DT.95128152  DT.121469059 
    DT.121469025  DT.97792095  DT.100780161  DT.92426993  DT.121141833  DT.97861882 

    24/115 AceView cDNA sequences (see all 115):

    BC039059 NM_020863 AW574536 AB167740 AA278764 BU542906 BF771219 BG012927 
    AB167741 BC046180 BU737631 BU166933 AB167739 BI964061 BG260556 AA809888 
    AB167738 F34409 AB040918 AA015612 BU838137 AI659389 AA069863 BC012989 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZFAT (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
    SP1:                                                                    -                                               -                           
    SP2:        -     -                                                     -                                               -                           
    SP3:        -     -     -                                               -                                               -                           
    SP4:                    -                                               -                                               -                           
    SP5:                    -                                               -                                         -     -     -     -               


    ECgene alternative splicing isoforms for ZFAT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFAT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCATCGGA
    ZFAT Expression
    About this image


    See ZFAT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFAT

    SOURCE GeneReport for Unigene cluster: Hs.446172

    UniProtKB/Swiss-Prot: ZFAT_HUMAN, Q9P243
    Tissue specificity: Isoform 1 is strongly expressed in placenta, spleen, kidney, testis and peripheral blood
    leukocytes. Expressed in CD4+ and CD8+ T-cells, CD19+ B-cells and CB14+ monocytes. Isoform 3 is strongly
    expressed in placenta, ovary, tonsil, CD19+ B-cells and CD14+ monocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZFAT gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfat1 , 5 zinc finger and AT hook domain containing1, 5 86.06(n)1
    88.75(a)1
      15 (29.44 cM)5
    3809931  NM_001145888.11  NP_001139360.11 
     680837665 
    chicken
    (Gallus gallus)
    Aves ZFAT1 zinc finger and AT hook domain containing 71.13(n)
    75.16(a)
      420319  XM_418429.3  XP_418429.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZFAT6
    zinc finger and AT hook domain containing
    72(a)
    1 ↔ 1
    4(1614628-1736668)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.174912 Transcribed sequence with weak similarity to protein more 78.07(n)    137734170 
    zebrafish
    (Danio rerio)
    Actinopterygii zfat1 zinc finger and AT hook domain containing 64.14(n)
    63.33(a)
      566334  XM_689606.4  XP_694698.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta her6
    hermaphrodite
    17(a)
    1 → many
    2L(16677210-16679383)
    worm
    (Caenorhabditis elegans)
    Secernentea slr-26
    Protein SLR-2, isoform b
    16(a)
    1 → many
    V(18087133-18098119)


    ENSEMBL Gene Tree for ZFAT (if available)
    TreeFam Gene Tree for ZFAT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFAT gene
    18/25 SIMAP similar genes for ZFAT using alignment to 11 protein entries:     ZFAT_HUMAN (see all proteins) (see all similar genes):
    ZNF429    CTCFL    DKFZp434J0650    DKFZp686N0199    REST    ZFX
    ZNF791    ZNF    ZNF78L1    ZNFN1A2    kr-znf3    ZNF345
    KLF1    KLF4    ZNF468    ZNF808    A-328A3.4    ZFP64

    ZFAT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5444 SNPs in ZFAT are shown (see all 5444)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs797788271,2
    C--130813918(+) AAGAG-/GAGAGAG 5 -- int10--------
    rs1481589071,2
    C--130820185(+) TTTTG-/TTTTTT 5 -- int10--------
    rs1997973971,2
    --130822015(+) CAATA-/TAACAC 5 -- int10--------
    rs769383301,2
    C,F--130826015(+) GAGCCG/AGGATG 5 -- int11Minor allele frequency- A:0.50NA 4
    rs784006071,2
    C--130876628(+) GTGTCC/TCTACC 5 -- int11Minor allele frequency- T:0.50NA 2
    rs1461963861,2
    C--130876631(+) TCCCT-/ACCACCTA 5 -- int10--------
    rs753023341,2
    C--130931406(+) AGAYT-/GKSCTA 5 -- int10--------
    rs106658581,2
    C--130939824(+) GAAAG-/AACAACAG 5 -- cds10--------
    rs712982141,2
    C--130995474(-) ACATAGGTAT   
       ATA
    /-
    TGTGC
    5 -- int11Minor allele frequency- -:0.00NA 2
    rs1464389111,2
    C--131019277(+) CGGGG-/C/C   
       CTGCA
    GCTCA
    10 -- int1 cds10--------

    HapMap Linkage Disequilibrium report for ZFAT (135490031 - 135725292 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for ZFAT (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1297525CNV Deletion17803354
    nsv820465CNV Deletion20802225
    esv2737628CNV Deletion23290073
    esv2737630CNV Deletion23290073
    esv2737627CNV Deletion23290073
    esv2660261CNV Deletion23128226
    esv2737626CNV Deletion23290073
    nsv525439CNV Loss19592680
    nsv397081CNV Loss16902084
    esv25625CNV Loss19812545


    Human Gene Mutation Database (HGMD): ZFAT
    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing ZFAT:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing ZFAT
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFAT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610931   
    OMIM disorders: 608175  
    7 diseases for ZFAT:    About MalaCards
    autoimmune thyroiditis    childhood type dermatomyositis    croup    dermatomyositis
    thyroiditis    tonsillitis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for ZFAT:
    Croup

    ZFAT for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZFAT
    Human Genome Epidemiology (HuGE) Navigator: ZFAT (5 documents)

    Export disorders for ZFAT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFAT gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with ZFAT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PubMed id 21998595)1, 4 N'Diaye A....Haiman C.A. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Genome-wide searching of rare genetic variants in WTC CC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (2010)
    5. Detecting rare variants for complex traits using fami ly and unrelated data. (PubMed id 19847924)1, 4 Zhu X....Elston R.C. (2010)
    6. Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (2010)
    7. ZFAT expression in B and T lymphocytes and identifica tion of ZFAT-regulated genes. (PubMed id 18329245)1, 3 Koyanagi M....Shirasawa S. (2008)
    8. SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease. (PubMed id 15294872)1, 2 Shirasawa S....Sasazuki T. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells. (PubMed id 19162026)1, 9 Fujimoto T....Shirasawa S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57623 HGNC: 19899 AceView: ZNF406 Ensembl:ENSG00000066827 euGenes: HUgn57623
    ECgene: ZFAT H-InvDB: ZFAT

    (According to HUGE)
    About This Section
    HUGE: KIAA1485

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFAT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFAT gene:
    Search GeneIP for patents involving ZFAT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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