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Aliases for ZFAND6 Gene

Aliases for ZFAND6 Gene

  • Zinc Finger AN1-Type Containing 6 2 3 5
  • Zinc Finger, A20 Domain Containing 3 2 3
  • Zinc Finger, AN1-Type Domain 6 2 3
  • Protein Associated With PRK1 2 3
  • ZA20D3 3 4
  • AWP1 3 4
  • Zinc Finger A20 Domain-Containing Protein 3 4
  • AN1-Type Zinc Finger Protein 6 3
  • Associated With PRK1 Protein 4
  • ZFAND5B 3

External Ids for ZFAND6 Gene

Previous HGNC Symbols for ZFAND6 Gene

  • ZA20D3

Previous GeneCards Identifiers for ZFAND6 Gene

  • GC15P078141
  • GC15P080351
  • GC15P057110

Summaries for ZFAND6 Gene

GeneCards Summary for ZFAND6 Gene

ZFAND6 (Zinc Finger AN1-Type Containing 6) is a Protein Coding gene. GO annotations related to this gene include polyubiquitin binding. An important paralog of this gene is ZFAND5.

UniProtKB/Swiss-Prot for ZFAND6 Gene

  • Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of Lys-48-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).

Additional gene information for ZFAND6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND6 Gene

Genomics for ZFAND6 Gene

Regulatory Elements for ZFAND6 Gene

Enhancers for ZFAND6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H080174 1.4 Ensembl ENCODE dbSUPER 11.7 +114.9 114868 1 RB1 RAD21 RFX5 YY1 GLIS2 SCRT2 FOS CEBPB REST ZEB2 FAH ZFAND6 RNU6-667P ENSG00000259967 GC15P080189
GH15H080008 1.1 FANTOM5 ENCODE 13.7 -48.8 -48849 3 HDGF KLF1 TBL1XR1 CHD4 EBF1 BATF RELA POLR3A EED ATF7 ZFAND6 BCL2A1 RNU6-667P MTHFS ST20 ENSG00000279705 ENSG00000279719
GH15H079894 1.4 ENCODE dbSUPER 10.7 -162.3 -162329 5 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SP3 MTHFS ST20 BCL2A1 ZFAND6 RNU6-667P KIAA1024 ENSG00000279394
GH15H080151 1.4 ENCODE dbSUPER 10.6 +94.6 94578 5 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 YY1 ZNF207 FOS ENSG00000259649 FAH ZFAND6 ENSG00000259967
GH15H080031 1.2 Ensembl ENCODE 11.9 -26.2 -26190 3 HDGF PKNOX1 FOXA2 FOS ATF7 RUNX3 JUNB ZNF491 MIER3 MAFF ZFAND6 BCL2A1 ST20 MTHFS RASGRF1 ENSG00000279705 ENSG00000275460
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFAND6 on UCSC Golden Path with GeneCards custom track

Promoters for ZFAND6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000079899 832 2801 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS

Genomic Location for ZFAND6 Gene

Chromosome:
15
Start:
80,059,568 bp from pter
End:
80,138,393 bp from pter
Size:
78,826 bases
Orientation:
Plus strand

Genomic View for ZFAND6 Gene

Genes around ZFAND6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND6 Gene

Proteins for ZFAND6 Gene

  • Protein details for ZFAND6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6FIF0-ZFAN6_HUMAN
    Recommended name:
    AN1-type zinc finger protein 6
    Protein Accession:
    Q6FIF0
    Secondary Accessions:
    • D3DW92
    • D3DW94
    • O95792
    • Q9BQF7
    • Q9GZY3

    Protein attributes for ZFAND6 Gene

    Size:
    208 amino acids
    Molecular mass:
    22555 Da
    Quaternary structure:
    • Interacts with PKN1 (By similarity). Interacts with TRAF2. Interacts with mono- and polyubiquitin. Interacts with PEX6. Interacts with PEX5 (Cys-linked ubiquitinated) (By similarity).
    SequenceCaution:
    • Sequence=AAD17528.1; Type=Frameshift; Positions=141; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFAND6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFAND6 Gene

Post-translational modifications for ZFAND6 Gene

  • Ubiquitination at isoforms=2137 and Lys186
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZFAND6 Gene

Domains & Families for ZFAND6 Gene

Gene Families for ZFAND6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZFAND6 Gene

Suggested Antigen Peptide Sequences for ZFAND6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6FIF0

UniProtKB/Swiss-Prot:

ZFAN6_HUMAN :
  • The A20-type zinc finger domain mediates regulation of NF-kappa-B activity.
Domain:
  • The A20-type zinc finger domain mediates regulation of NF-kappa-B activity.
  • The AN1-type zinc finger domain mediates association with TRAF2.
genes like me logo Genes that share domains with ZFAND6: view

Function for ZFAND6 Gene

Molecular function for ZFAND6 Gene

UniProtKB/Swiss-Prot Function:
Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of Lys-48-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).

Phenotypes From GWAS Catalog for ZFAND6 Gene

Gene Ontology (GO) - Molecular Function for ZFAND6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0031593 polyubiquitin binding ISS --
genes like me logo Genes that share ontologies with ZFAND6: view
genes like me logo Genes that share phenotypes with ZFAND6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZFAND6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND6 Gene

Localization for ZFAND6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFAND6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFAND6 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ZFAND6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZFAND6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZFAND6 Gene

Pathways & Interactions for ZFAND6 Gene

SuperPathways for ZFAND6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006625 protein targeting to peroxisome ISS --
GO:0006810 transport IEA --
GO:0006915 apoptotic process IEA --
GO:0015031 protein transport IEA --
GO:0043066 negative regulation of apoptotic process IMP 21810480
genes like me logo Genes that share ontologies with ZFAND6: view

No data available for Pathways by source and SIGNOR curated interactions for ZFAND6 Gene

Drugs & Compounds for ZFAND6 Gene

No Compound Related Data Available

Transcripts for ZFAND6 Gene

Unigene Clusters for ZFAND6 Gene

Zinc finger, AN1-type domain 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZFAND6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND6 Gene

No ASD Table

Relevant External Links for ZFAND6 Gene

GeneLoc Exon Structure for
ZFAND6
ECgene alternative splicing isoforms for
ZFAND6

Expression for ZFAND6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFAND6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFAND6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.8), Islet of Langerhans (13.2), Monocytes (11.1), and Fetal ovary (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFAND6 Gene



Protein tissue co-expression partners for ZFAND6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFAND6 Gene:

ZFAND6

SOURCE GeneReport for Unigene cluster for ZFAND6 Gene:

Hs.596679

mRNA Expression by UniProt/SwissProt for ZFAND6 Gene:

Q6FIF0-ZFAN6_HUMAN
Tissue specificity: Widely expressed with high level in heart, skeletal muscle, liver, kidney and placenta.

Evidence on tissue expression from TISSUES for ZFAND6 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Kidney(4.3)
  • Lung(2.6)
genes like me logo Genes that share expression patterns with ZFAND6: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFAND6 Gene

Orthologs for ZFAND6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZFAND6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFAND6 33 34
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia ZFAND6 33
  • 94.87 (n)
-- 34
  • 92 (a)
OneToMany
-- 34
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfand6 33 16 34
  • 93.59 (n)
cow
(Bos Taurus)
Mammalia ZFAND6 33 34
  • 93.43 (n)
rat
(Rattus norvegicus)
Mammalia Zfand6 33
  • 92.95 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFAND6 34
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFAND6 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFAND6 33 34
  • 85.83 (n)
lizard
(Anolis carolinensis)
Reptilia ZFAND6 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfand6 33
  • 64.18 (n)
MGC75964 33
African clawed frog
(Xenopus laevis)
Amphibia awp1-pending-prov 33
zebrafish
(Danio rerio)
Actinopterygii zfand6 33 34
  • 59.24 (n)
wufb11b11 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1185 33
fruit fly
(Drosophila melanogaster)
Insecta CG43674 33 34
  • 51.68 (n)
CG15368 34
  • 29 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003649 33
  • 49.68 (n)
worm
(Caenorhabditis elegans)
Secernentea F22D6.2 34
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G52800 33
  • 51.3 (n)
rice
(Oryza sativa)
Liliopsida Os03g0792900 33
  • 53.47 (n)
Species where no ortholog for ZFAND6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFAND6 Gene

ENSEMBL:
Gene Tree for ZFAND6 (if available)
TreeFam:
Gene Tree for ZFAND6 (if available)

Paralogs for ZFAND6 Gene

Paralogs for ZFAND6 Gene

Pseudogenes.org Pseudogenes for ZFAND6 Gene

genes like me logo Genes that share paralogs with ZFAND6: view

Variants for ZFAND6 Gene

Sequence variations from dbSNP and Humsavar for ZFAND6 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000040394 -- 80,074,955(+) GAACC(A/G)GTAGT intron-variant
rs1000043693 -- 80,090,904(+) GACAC(C/T)CTTAA intron-variant
rs1000109405 -- 80,117,592(+) AAAAG(A/G)CAGTT intron-variant
rs1000119848 -- 80,117,265(+) TTGCC(A/C)AGGCT intron-variant
rs1000143688 -- 80,126,600(+) AAGAA(A/T)GAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFAND6 Gene

Variant ID Type Subtype PubMed ID
esv2669126 CNV deletion 23128226
esv2749943 CNV deletion 23290073
esv2749944 CNV deletion 23290073
esv3637013 CNV loss 21293372
nsv1634 CNV deletion 18451855
nsv526014 CNV loss 19592680

Variation tolerance for ZFAND6 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFAND6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFAND6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND6 Gene

Disorders for ZFAND6 Gene

Relevant External Links for ZFAND6

Genetic Association Database (GAD)
ZFAND6
Human Genome Epidemiology (HuGE) Navigator
ZFAND6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFAND6

No disorders were found for ZFAND6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND6 Gene

Publications for ZFAND6 Gene

  1. Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo. (PMID: 11054541) Duan W … Teo TS (Gene 2000) 2 3 4 22 60
  2. AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling. (PMID: 21810480) Chang EJ … Kim HH (The international journal of biochemistry & cell biology 2011) 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PMID: 20581827) Voight BF … GIANT Consortium (Nature genetics 2010) 3 45 60
  5. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T … Zhu X (Human genetics 2010) 3 45 60

Products for ZFAND6 Gene

Sources for ZFAND6 Gene

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