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Aliases for ZFAND6 Gene

Aliases for ZFAND6 Gene

  • Zinc Finger, AN1-Type Domain 6 2 3
  • ZA20D3 3 4 6
  • AWP1 3 4 6
  • Zinc Finger, A20 Domain Containing 3 2 3
  • Protein Associated With PRK1 2 3
  • Zinc Finger A20 Domain-Containing Protein 3 4
  • AN1-Type Zinc Finger Protein 6 3
  • Associated With PRK1 Protein 4
  • ZFAND5B 3

External Ids for ZFAND6 Gene

Previous Symbols for ZFAND6 Gene

  • ZA20D3

Summaries for ZFAND6 Gene

GeneCards Summary for ZFAND6 Gene

ZFAND6 (Zinc Finger, AN1-Type Domain 6) is a Protein Coding gene. GO annotations related to this gene include polyubiquitin binding. An important paralog of this gene is ZFAND5.

UniProtKB/Swiss-Prot for ZFAND6 Gene

  • Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of Lys-48-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND6 Gene

Genomics for ZFAND6 Gene

Genomic Location for ZFAND6 Gene

Start:
80,059,568 bp from pter
End:
80,138,393 bp from pter
Size:
78,826 bases
Orientation:
Plus strand

Genomic View for ZFAND6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFAND6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND6 Gene

Regulatory Elements for ZFAND6 Gene

Proteins for ZFAND6 Gene

  • Protein details for ZFAND6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6FIF0-ZFAN6_HUMAN
    Recommended name:
    AN1-type zinc finger protein 6
    Protein Accession:
    Q6FIF0
    Secondary Accessions:
    • D3DW92
    • D3DW94
    • O95792
    • Q9BQF7
    • Q9GZY3

    Protein attributes for ZFAND6 Gene

    Size:
    208 amino acids
    Molecular mass:
    22555 Da
    Quaternary structure:
    • Interacts with PKN1 (By similarity). Interacts with TRAF2. Interacts with mono- and polyubiquitin. Interacts with PEX6. Interacts with PEX5 (Cys-linked ubiquitinated) (By similarity).
    SequenceCaution:
    • Sequence=AAD17528.1; Type=Frameshift; Positions=141; Evidence={ECO:0000305};

    Alternative splice isoforms for ZFAND6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFAND6 Gene

Proteomics data for ZFAND6 Gene at MOPED

Post-translational modifications for ZFAND6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys137 and Lys186

No data available for DME Specific Peptides for ZFAND6 Gene

Domains for ZFAND6 Gene

Gene Families for ZFAND6 Gene

HGNC:
  • ZFAND :Zinc fingers, AN1-type domain containing

Protein Domains for ZFAND6 Gene

UniProtKB/Swiss-Prot:

ZFAN6_HUMAN
Domain:
  • The A20-type zinc finger domain mediates regulation of NF-kappa-B activity:
    • Q6FIF0
  • The AN1-type zinc finger domain mediates association with TRAF2:
    • Q6FIF0
Similarity:
  • Contains 1 A20-type zinc finger.:
    • Q6FIF0
  • Contains 1 AN1-type zinc finger.:
    • Q6FIF0
genes like me logo Genes that share domains with ZFAND6: view

Function for ZFAND6 Gene

Molecular function for ZFAND6 Gene

UniProtKB/Swiss-Prot Function: Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of Lys-48-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).

Gene Ontology (GO) - Molecular Function for ZFAND6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0031593 polyubiquitin binding ISS --
genes like me logo Genes that share ontologies with ZFAND6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZFAND6 Gene

Localization for ZFAND6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFAND6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFAND6 Gene COMPARTMENTS Subcellular localization image for ZFAND6 gene
Compartment Confidence
nucleus 2
cytoskeleton 1
cytosol 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZFAND6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZFAND6: view

Pathways for ZFAND6 Gene

SuperPathways for ZFAND6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006625 protein targeting to peroxisome ISS --
GO:0006915 apoptotic process IEA --
GO:0043066 negative regulation of apoptotic process IMP 21810480
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IMP 21810480
GO:0071356 cellular response to tumor necrosis factor IMP 21810480
genes like me logo Genes that share ontologies with ZFAND6: view

No data available for Pathways by source for ZFAND6 Gene

Transcripts for ZFAND6 Gene

Unigene Clusters for ZFAND6 Gene

Zinc finger, AN1-type domain 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND6 Gene

No ASD Table

Relevant External Links for ZFAND6 Gene

GeneLoc Exon Structure for
ZFAND6
ECgene alternative splicing isoforms for
ZFAND6

Expression for ZFAND6 Gene

mRNA expression in normal human tissues for ZFAND6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFAND6 Gene

SOURCE GeneReport for Unigene cluster for ZFAND6 Gene Hs.596679

mRNA Expression by UniProt/SwissProt for ZFAND6 Gene

Q6FIF0-ZFAN6_HUMAN
Tissue specificity: Widely expressed with high level in heart, skeletal muscle, liver, kidney and placenta.
genes like me logo Genes that share expressions with ZFAND6: view

Orthologs for ZFAND6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZFAND6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFAND6 36
  • 99.04 (n)
  • 99.52 (a)
ZFAND6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFAND6 36
  • 93.43 (n)
  • 95.67 (a)
ZFAND6 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 79 (a)
OneToMany
-- 37
  • 92 (a)
OneToMany
ZFAND6 36
  • 94.87 (n)
  • 95.19 (a)
mouse
(Mus musculus)
Mammalia Zfand6 36
  • 93.59 (n)
  • 94.71 (a)
Zfand6 16
Zfand6 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFAND6 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFAND6 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfand6 36
  • 92.95 (n)
  • 94.71 (a)
chicken
(Gallus gallus)
Aves ZFAND6 36
  • 85.83 (n)
  • 86.96 (a)
ZFAND6 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFAND6 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia awp1-pending-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75964 36
zfand6 36
  • 64.18 (n)
  • 66.17 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1185 36
zebrafish
(Danio rerio)
Actinopterygii wufb11b11 36
zfand6 36
  • 59.24 (n)
  • 60.4 (a)
zfand6 37
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003649 36
  • 49.68 (n)
  • 45.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15368 37
  • 29 (a)
ManyToMany
CG43674 36
  • 51.68 (n)
  • 44.44 (a)
CG43674 37
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F22D6.2 37
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G52800 36
  • 51.3 (n)
  • 47.31 (a)
rice
(Oryza sativa)
Liliopsida Os03g0792900 36
  • 53.47 (n)
  • 46.31 (a)
Species with no ortholog for ZFAND6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFAND6 Gene

ENSEMBL:
Gene Tree for ZFAND6 (if available)
TreeFam:
Gene Tree for ZFAND6 (if available)

Paralogs for ZFAND6 Gene

Paralogs for ZFAND6 Gene

Pseudogenes.org Pseudogenes for ZFAND6 Gene

genes like me logo Genes that share paralogs with ZFAND6: view

Variants for ZFAND6 Gene

Sequence variations from dbSNP and Humsavar for ZFAND6 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs12577 -- 80,131,235(-) GGTTT(A/T)TCAAG reference, missense, intron-variant
rs12890 -- 80,137,608(-) CTTTT(C/T)ACCAA missense, reference
rs15416 -- 80,131,245(-) TTTTT(A/G)TTTCG reference, stop-gained, intron-variant
rs870184 -- 80,098,716(+) GGTAG(G/T)ATACT intron-variant
rs870185 -- 80,098,915(+) CAGCC(A/G)TTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFAND6 Gene

Variant ID Type Subtype PubMed ID
nsv526014 CNV Loss 19592680
esv2669126 CNV Deletion 23128226
esv2749943 CNV Deletion 23290073
esv2749944 CNV Deletion 23290073
nsv1634 CNV Loss 18451855

Relevant External Links for ZFAND6 Gene

HapMap Linkage Disequilibrium report
ZFAND6

Disorders for ZFAND6 Gene

Relevant External Links for ZFAND6

Genetic Association Database (GAD)
ZFAND6
Human Genome Epidemiology (HuGE) Navigator
ZFAND6
genes like me logo Genes that share disorders with ZFAND6: view

No data available for UniProtKB/Swiss-Prot for ZFAND6 Gene

Publications for ZFAND6 Gene

  1. Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo. (PMID: 11054541) Duan W. … Teo T.S. (Gene 2000) 2 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling. (PMID: 21810480) Chang E.J. … Kim H.H. (Int. J. Biochem. Cell Biol. 2011) 3 4
  5. Identification of polyubiquitin binding proteins involved in NF- kappaB signaling using protein arrays. (PMID: 19285159) Fenner B.J. … Prehn J.H. (Biochim. Biophys. Acta 2009) 3 4

Products for ZFAND6 Gene

Sources for ZFAND6 Gene

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