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ZFAND6 Gene

protein-coding   GIFtS: 51
GCID: GC15P080351

Zinc Finger, AN1-Type Domain 6

(Previous names: zinc finger, A20 domain containing 3)
(Previous symbol: ZA20D3)
  Search for ZFAND6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, AN1-Type Domain 61 2     ZFAND5B2
ZA20D31 2 3 5     AN1-Type Zinc Finger Protein 62
AWP12 3 5     Associated With PRK1 Protein3
Zinc Finger, A20 Domain Containing 31 2     Zinc Finger A20 Domain-Containing Protein 33
Protein Associated With PRK11 2     

External Ids:    HGNC: 301641   Entrez Gene: 544692   Ensembl: ENSG000000866667   OMIM: 6101835   UniProtKB: Q6FIF03   

Export aliases for ZFAND6 gene to outside databases

Previous GC identifers: GC15P078141 GC15P057110


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZFAND6 Gene:
ZFAND6 (zinc finger, AN1-type domain 6) is a protein-coding gene. GO annotations related to this gene include polyubiquitin binding. An important paralog of this gene is ZFAND5.

UniProtKB/Swiss-Prot: ZFAN6_HUMAN, Q6FIF0
Function: Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation
of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for
PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In
vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFAND6 gene promoter:
         NF-AT   Gfi-1   SRY   NF-AT4   CBF-B   CBF-A   NF-AT2   NF-AT3   NF-AT1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFAND6 promoter sequence
   Search Chromatin IP Primers for ZFAND6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFAND6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q24.3

ZFAND6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFAND6 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P080351:  view genomic region     (about GC identifiers)

Start:
80,351,910 bp from pter      End:
80,430,735 bp from pter
Size:
78,826 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZFAN6_HUMAN, Q6FIF0 (See protein sequence)
Recommended Name: AN1-type zinc finger protein 6  
Size: 208 amino acids; 22555 Da
Subunit: Interacts with PKN1 (By similarity). Interacts with TRAF2. Interacts with mono- and polyubiquitin.
Interacts with PEX6. Interacts with PEX5 (Cys-linked ubiquitinated) (By similarity)
Sequence caution: Sequence=AAD17528.1; Type=Frameshift; Positions=141;
Secondary accessions: D3DW92 D3DW94 O95792 Q9BQF7 Q9GZY3
Alternative splicing: 2 isoforms:  Q6FIF0-1   Q6FIF0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZFAND6: NX_Q6FIF0

Explore proteomics data for ZFAND6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys137, Lys186
  • Modification sites at PhosphoSitePlus

  • See ZFAND6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (10 alternative transcripts): 
    NP_001229840.1  NP_001229841.1  NP_001229842.1  NP_001229843.1  NP_001229844.1  NP_001229845.1  NP_001229846.1  NP_001229847.1  
    NP_001229848.1  NP_061879.2  

    ENSEMBL proteins: 
     ENSP00000261749   ENSP00000452735   ENSP00000454152   ENSP00000453590   ENSP00000454273  
     ENSP00000454137   ENSP00000455515   ENSP00000454409   ENSP00000453291   ENSP00000453709  
     ENSP00000452664   ENSP00000455146   ENSP00000453710   ENSP00000456973   ENSP00000453308  
     ENSP00000453571   ENSP00000453888   ENSP00000452625  

    ZFAND6 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ZFAND6

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFAND: Zinc fingers, AN1-type domain containing

    2 InterPro protein domains:
     IPR000058 Znf_AN1
     IPR002653 Znf_A20

    Graphical View of Domain Structure for InterPro Entry Q6FIF0

    ProtoNet protein and cluster: Q6FIF0

    2 Blocks protein domains:
    IPB000058 Zn-finger
    IPB002653 Zn-finger


    UniProtKB/Swiss-Prot: ZFAN6_HUMAN, Q6FIF0
    Domain: The A20-type zinc finger domain mediates regulation of NF-kappa-B activity
    Domain: The AN1-type zinc finger domain mediates association with TRAF2
    Similarity: Contains 1 A20-type zinc finger
    Similarity: Contains 1 AN1-type zinc finger


    Find genes that share domains with ZFAND6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFAN6_HUMAN, Q6FIF0
    Function: Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation
    of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for
    PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In
    vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding IEA--
    GO:0031593polyubiquitin binding ISS--
         
    Find genes that share ontologies with ZFAND6           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZFAND6
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    Selected qRT-PCR Assays for microRNAs that regulate ZFAND6 (see all 24):
    hsa-miR-3678-3p hsa-miR-26a-2* hsa-miR-181c hsa-miR-429 hsa-miR-3662 hsa-miR-3148 hsa-miR-200b hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidZFAND6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZFAND6

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    Sino Biological Human cDNA Clone for ZFAND6
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZFAN6_HUMAN, Q6FIF0: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytoskeleton1
    cytosol1
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with ZFAND6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFAND6
    Interactions:

        Search GeneGlobe Interaction Network for ZFAND6

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for ZFAND6 (Q6FIF01, 2, 3 ENSP000002617494) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF2Q129331, 3, ENSP000002476684EBI-724630,EBI-355744 I2D: score=5 STRING: ENSP00000247668
    DNM2P505703, ENSP000003527214I2D: score=3 STRING: ENSP00000352721
    CDC34P494273, ENSP000002155744I2D: score=1 STRING: ENSP00000215574
    PKN1Q165123, ENSP000003433254I2D: score=1 STRING: ENSP00000343325
    UBCP0CG483I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006625protein targeting to peroxisome ISS--
    GO:0006915apoptotic process IEA--
    GO:0043066negative regulation of apoptotic process IMP--
    GO:0043122regulation of I-kappaB kinase/NF-kappaB signaling IMP--
    GO:0071356cellular response to tumor necrosis factor IMP--

    Find genes that share ontologies with ZFAND6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFAND6 (ZFAN6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZFAND6 gene (10 alternative transcripts): 
    NM_001242911.1  NM_001242912.1  NM_001242913.1  NM_001242914.1  NM_001242915.1  NM_001242916.1  NM_001242917.1  NM_001242918.1  
    NM_001242919.1  NM_019006.3  

    Unigene Cluster for ZFAND6:

    Zinc finger, AN1-type domain 6
    Hs.596679  [show with all ESTs]
    Unigene Representative Sequence: CR749384
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000261749(uc002bfe.2 uc021srv.1 uc021srw.1 uc002bfg.2 uc002bff.2 uc021srx.1 uc021sry.1)
    ENST00000561060 ENST00000559157 ENST00000561012 ENST00000564367 ENST00000558494
    ENST00000560470 ENST00000560228 ENST00000559835(uc002bfi.2) ENST00000559775(uc002bfh.2)
    ENST00000558688 ENST00000560392 ENST00000560976 ENST00000558272 ENST00000558390
    ENST00000557793 ENST00000558997 ENST00000558087
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZFAND6 (see all 24):
    hsa-miR-3678-3p hsa-miR-26a-2* hsa-miR-181c hsa-miR-429 hsa-miR-3662 hsa-miR-3148 hsa-miR-200b hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidZFAND6 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZFAND6
      QuantiFast Probe-based Assays in human, mouse, rat ZFAND6

    Additional mRNA sequence: 

    AF061739.1 AF261138.1 AJ251095.1 AK055881.1 AK312646.1 AL136598.1 BC005283.1 BC026239.1 
    CR533476.1 CR749384.1 

    Selected DOTS entries (see all 30):

    DT.448930  DT.100824107  DT.91763698  DT.100824104  DT.100824105  DT.100824106  DT.95199156  DT.100824102 
    DT.424371  DT.100824101  DT.95256429  DT.95256427  DT.86857902  DT.97775218  DT.121017418  DT.121017428 
    DT.100824097  DT.100824098  DT.100824100  DT.121017394  DT.121017402  DT.121017435  DT.121017447  DT.91763695 

    Selected AceView cDNA sequences (see all 408):

    BU620116 CA413145 AA233777 CB156940 BX358250 CA773536 AA732389 BF969851 
    BM982579 AF261138 AW268698 BM692973 AI631228 CR621158 BP369691 AW157189 
    AA743021 BQ432724 AA313266 BM976611 BM728448 BM982626 BQ014547 BM800128 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFAND6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTTGTGTG
    ZFAND6 Expression
    About this image


    ZFAND6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             Bone Marrow
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    ZFAND6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFAND6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.596679

    UniProtKB/Swiss-Prot: ZFAN6_HUMAN, Q6FIF0
    Tissue specificity: Widely expressed with high level in heart, skeletal muscle, liver, kidney and placenta

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZFAND6 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfand61 , 5 zinc finger, AN1-type domain 61, 5 93.59(n)1
    94.71(a)1
      7 (48.36 cM)5
    650981  NM_022985.61  NP_075361.21 
     846150545 
    chicken
    (Gallus gallus)
    Aves ZFAND61 zinc finger, AN1-type domain 6 85.83(n)
    86.96(a)
      415483  NM_001277522.1  NP_001264451.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZFAND66
    zinc finger, AN1-type domain 6
    77(a)
    1 ↔ 1
    GL343332.1(483788-502917)
    African clawed frog
    (Xenopus laevis)
    Amphibia awp1-pending-prov2 protein associated with PRK1 75.83(n)    BC042359.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb11b112 Danio rerio cDNA clone IMAGE6791371, partial cds 76.93(n)    AY398314.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG436741 CG43674 51.68(n)
    44.44(a)
      41114  NM_001031991.3  NP_001027162.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F22D6.26
    Protein F22D6.2 (F22D6.2) mRNA, complete cds
    36(a)
    1 → many
    I(7079911-7082020) WBGene00009050
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G528001 AT3G52800 51.3(n)
    47.31(a)
      824446  NM_115140.2  NP_190848.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07929001 Os03g0792900 53.47(n)
    46.31(a)
      4334392  NM_001058062.1  NP_001051527.1 


    ENSEMBL Gene Tree for ZFAND6 (if available)
    TreeFam Gene Tree for ZFAND6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZFAND6 gene
    ZFAND52  
    3 SIMAP similar genes for ZFAND6 using alignment to 12 protein entries:     ZFAN6_HUMAN (see all proteins):
    LOC158381    RABGEF1    ZFAND5

    Find genes that share paralogs with ZFAND6           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZFAND6
    PGOHUM00000261990


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFAND6 (see all 1636)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs801172921,2
    C,F--80350005(+) CCACCG/AGCATG 5 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1832421831,2
    C--80350113(+) ACTGGA/TAACAT 5 -- us2k10--------
    rs1416812231,2
    --80350118(+) AAACAC/TGGTGT 5 -- us2k10--------
    rs1461816731,2
    --80350172(+) GGGGGA/TAAATA 5 -- us2k10--------
    rs1881184911,2
    --80350235(+) TGGAAC/TACAGG 5 -- us2k10--------
    rs1917526971,2
    --80350289(+) ATTGAA/GCATCT 6 -- us2k10--------
    rs1835259961,2
    --80350350(+) GTTGCA/GTATGT 6 -- us2k10--------
    rs1877543311,2
    --80350468(+) AGAGTC/TGGCAT 6 -- us2k10--------
    rs1925457451,2
    --80350519(+) CCCTCA/TTAACA 7 -- us2k10--------
    rs1145946071,2
    C,F--80350534(+) TTTGTG/AGTAGG 7 -- us2k11Minor allele frequency- A:0.09WA 118

    HapMap Linkage Disequilibrium report for ZFAND6 (80351910 - 80430735 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZFAND6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749944CNV Deletion23290073
    esv2749943CNV Deletion23290073
    esv2669126CNV Deletion23128226
    nsv1634CNV Loss18451855
    nsv526014CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFAND6
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFAND6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610183    OMIM disorders: --


    Find genes that share disorders with ZFAND6           About GenesLikeMe

    Genetic Association Database (GAD): ZFAND6
    Human Genome Epidemiology (HuGE) Navigator: ZFAND6 (7 documents)

    Export disorders for ZFAND6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFAND6 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with ZFAND6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo. (PubMed id 11054541)1, 2, 3, 9 Duan W.... Teo T.S. (Gene 2000)
    2. AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling. (PubMed id 21810480)1, 2 Chang E.J.... Kim H.H. (Int. J. Biochem. Cell Biol. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genome-wide searching of rare genetic variants in WTCCC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (Hum. Genet. 2010)
    5. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PubMed id 20581827)1, 4 Voight B.F.... . (Nat. Genet. 2010)
    6. Identification of polyubiquitin binding proteins involved in NF- kappaB signaling using protein arrays. (PubMed id 19285159)1, 2 Fenner B.J.... Prehn J.H. (Biochim. Biophys. Acta 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54469 HGNC: 30164 AceView: ZA20D3 Ensembl:ENSG00000086666 euGenes: HUgn54469
    ECgene: ZFAND6 H-InvDB: ZFAND6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZFAND6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFAND6 gene:
    Search GeneIP for patents involving ZFAND6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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