Aliases for ZFAND5 Gene
External Ids for ZFAND5 Gene
Previous Symbols for ZFAND5 Gene
GeneCards Summary for ZFAND5 Gene
ZFAND5 (Zinc Finger, AN1-Type Domain 5) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway and FoxO family signaling. An important paralog of this gene is ZFAND6.
UniProtKB/Swiss-Prot for ZFAND5 Gene
Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.