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Aliases for ZFAND5 Gene

Aliases for ZFAND5 Gene

  • Zinc Finger AN1-Type Containing 5 2 3 5
  • Zinc Finger Protein 216 2 3 4
  • Zinc Finger A20 Domain-Containing Protein 2 3 4
  • Zinc Finger, A20 Domain Containing 2 2 3
  • Zinc Finger, AN1-Type Domain 5 2 3
  • ZA20D2 3 4
  • ZNF216 3 4
  • AN1-Type Zinc Finger Protein 5 3
  • ZFAND5A 3

External Ids for ZFAND5 Gene

Previous HGNC Symbols for ZFAND5 Gene

  • ZNF216
  • ZA20D2

Previous GeneCards Identifiers for ZFAND5 Gene

  • GC09M074159
  • GC09M074966
  • GC09M044789

Summaries for ZFAND5 Gene

GeneCards Summary for ZFAND5 Gene

ZFAND5 (Zinc Finger AN1-Type Containing 5) is a Protein Coding gene. Among its related pathways are FoxO family signaling. An important paralog of this gene is ZFAND6.

UniProtKB/Swiss-Prot for ZFAND5 Gene

  • Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.

Additional gene information for ZFAND5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND5 Gene

Genomics for ZFAND5 Gene

Regulatory Elements for ZFAND5 Gene

Enhancers for ZFAND5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H072538 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -176.1 -176056 4 HDGF PKNOX1 ATF1 ARNT BRCA1 YY1 TCF12 ZNF766 ATF7 NCOA1 ZFAND5 TMC1 LINC01474 LOC101927234 LOC101927191
GH09H072396 1.1 Ensembl ENCODE 18.6 -31.5 -31454 0 FOXA2 RARA RFX5 RCOR1 FOS CEBPB NFIL3 PRDM6 KLF16 CEBPA ZFAND5 TMC1 LINC01504 GC09P072407
GH09H072473 1.4 FANTOM5 Ensembl ENCODE 9.6 -109.0 -108975 2 HDGF JUN BMI1 BATF RELA EED FOS ATF7 RUNX3 MAFK TMC1 ZFAND5 LOC100289351 LOC105376080
GH09H072575 1.2 Ensembl ENCODE 10.6 -214.1 -214129 7 ARNT YY1 TCF12 GATA2 ATF7 FOS ZC3H11A NCOA1 SMARCB1 ZNF592 TMC1 ZFAND5 LINC01474 LOC101927191 GC09M072656
GH09H072359 1.6 Ensembl ENCODE dbSUPER 7.7 +2.2 2173 7 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZFAND5 TMC1 LINC01504 ANXA1 GC09P072358
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFAND5 on UCSC Golden Path with GeneCards custom track

Promoters for ZFAND5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000235866 1447 4801 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for ZFAND5 Gene

Chromosome:
9
Start:
72,351,425 bp from pter
End:
72,365,247 bp from pter
Size:
13,823 bases
Orientation:
Minus strand

Genomic View for ZFAND5 Gene

Genes around ZFAND5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND5 Gene

Proteins for ZFAND5 Gene

  • Protein details for ZFAND5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76080-ZFAN5_HUMAN
    Recommended name:
    AN1-type zinc finger protein 5
    Protein Accession:
    O76080
    Secondary Accessions:
    • A8K484

    Protein attributes for ZFAND5 Gene

    Size:
    213 amino acids
    Molecular mass:
    23132 Da
    Quaternary structure:
    • Interacts with ubiquitin and polyubiquitinated proteins. Identified in a heterotrimeric complex with ubiquitin and SQSTM1, where ZFAND5 and SQSTM1 both interact with the same ubiquitin molecule (By similarity). Homooligomer and/or heterooligomer. Interacts (via A20-type domain) with IKBKG and RIPK1 and with TRAF6 (via AN1-type domain).

neXtProt entry for ZFAND5 Gene

Post-translational modifications for ZFAND5 Gene

  • Ubiquitination at Lys86, Lys183, and isoforms=191
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZFAND5 Gene

Domains & Families for ZFAND5 Gene

Gene Families for ZFAND5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZFAND5 Gene

Suggested Antigen Peptide Sequences for ZFAND5 Gene

Graphical View of Domain Structure for InterPro Entry

O76080

UniProtKB/Swiss-Prot:

ZFAN5_HUMAN :
  • The A20-type zinc finger directly binds polyubiquitin chains and associates with the 26S proteasome. The zinc-finger A20-type domain is essential for inhibition of NF-kappa-B activation (By similarity).
Domain:
  • The A20-type zinc finger directly binds polyubiquitin chains and associates with the 26S proteasome. The zinc-finger A20-type domain is essential for inhibition of NF-kappa-B activation (By similarity).
genes like me logo Genes that share domains with ZFAND5: view

Function for ZFAND5 Gene

Molecular function for ZFAND5 Gene

UniProtKB/Swiss-Prot Function:
Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.

Gene Ontology (GO) - Molecular Function for ZFAND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16424905
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFAND5: view
genes like me logo Genes that share phenotypes with ZFAND5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ZFAND5

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZFAND5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND5 Gene

Localization for ZFAND5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFAND5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFAND5 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFAND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZFAND5: view

Pathways & Interactions for ZFAND5 Gene

SuperPathways for ZFAND5 Gene

SuperPathway Contained pathways
1 FoxO family signaling
genes like me logo Genes that share pathways with ZFAND5: view

Pathways by source for ZFAND5 Gene

1 BioSystems pathway for ZFAND5 Gene

Gene Ontology (GO) - Biological Process for ZFAND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001944 vasculature development IEA --
GO:0003016 respiratory system process IEA --
GO:0008150 biological_process ND --
GO:0010761 fibroblast migration IEA --
genes like me logo Genes that share ontologies with ZFAND5: view

No data available for SIGNOR curated interactions for ZFAND5 Gene

Drugs & Compounds for ZFAND5 Gene

No Compound Related Data Available

Transcripts for ZFAND5 Gene

Unigene Clusters for ZFAND5 Gene

Zinc finger, AN1-type domain 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZFAND5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: - -

Relevant External Links for ZFAND5 Gene

GeneLoc Exon Structure for
ZFAND5
ECgene alternative splicing isoforms for
ZFAND5

Expression for ZFAND5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFAND5 Gene

mRNA differential expression in normal tissues according to GTEx for ZFAND5 Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for ZFAND5 Gene

This gene is overexpressed in Breast (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFAND5 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZFAND5 Gene:

ZFAND5

SOURCE GeneReport for Unigene cluster for ZFAND5 Gene:

Hs.406096

mRNA Expression by UniProt/SwissProt for ZFAND5 Gene:

O76080-ZFAN5_HUMAN
Tissue specificity: Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly expressed or undetectable in adult brain, heart, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Expressed in rhabdomyosarcoma RD cells (at protein level).

Evidence on tissue expression from TISSUES for ZFAND5 Gene

  • Nervous system(4.8)
  • Lung(4.7)
  • Eye(4.5)
  • Skin(4.5)
  • Kidney(2.4)
  • Liver(2.4)
  • Adrenal gland(2.2)
  • Bone marrow(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ZFAND5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFAND5 Gene

Orthologs for ZFAND5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZFAND5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFAND5 33
  • 100 (n)
cow
(Bos Taurus)
Mammalia ZFAND5 33 34
  • 97.18 (n)
dog
(Canis familiaris)
Mammalia ZFAND5 33 34
  • 97.18 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFAND5 34
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfand5 33 16 34
  • 96.71 (n)
rat
(Rattus norvegicus)
Mammalia Zfand5 33
  • 96.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZFAND5 34
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFAND5 33 34
  • 89.26 (n)
lizard
(Anolis carolinensis)
Reptilia ZFAND5 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfand5 33
  • 82.94 (n)
Str.6493 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12007 33
zebrafish
(Danio rerio)
Actinopterygii zfand5b 33 34
  • 68.25 (n)
zfand5a 34
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43674 34
  • 40 (a)
ManyToMany
CG15368 34
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_F22D6.2 33
  • 49.91 (n)
F22D6.2 34
  • 42 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os03g0793000 33
  • 49.2 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11284 33
Species where no ortholog for ZFAND5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFAND5 Gene

ENSEMBL:
Gene Tree for ZFAND5 (if available)
TreeFam:
Gene Tree for ZFAND5 (if available)

Paralogs for ZFAND5 Gene

Paralogs for ZFAND5 Gene

(2) SIMAP similar genes for ZFAND5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZFAND5 Gene

genes like me logo Genes that share paralogs with ZFAND5: view

Variants for ZFAND5 Gene

Sequence variations from dbSNP and Humsavar for ZFAND5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000067963 -- 72,364,189(+) CTCTC(C/T)GAAAA intron-variant
rs1000090968 -- 72,358,082(+) AATGC(C/T)ATTAG intron-variant
rs1000253469 -- 72,358,345(+) GCCAC(A/C)TCTGA intron-variant
rs1000447990 -- 72,364,935(+) AGCGA(-/G)GGGGG upstream-variant-2KB, utr-variant-5-prime
rs1000686946 -- 72,354,384(+) AGCCA(C/T)GTAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZFAND5 Gene

Variant ID Type Subtype PubMed ID
nsv951527 CNV duplication 24416366

Variation tolerance for ZFAND5 Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFAND5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFAND5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND5 Gene

Disorders for ZFAND5 Gene

Relevant External Links for ZFAND5

Genetic Association Database (GAD)
ZFAND5
Human Genome Epidemiology (HuGE) Navigator
ZFAND5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFAND5

No disorders were found for ZFAND5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND5 Gene

Publications for ZFAND5 Gene

  1. Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. (PMID: 9758550) Scott DA … Sheffield VC (Gene 1998) 2 3 4 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation. (PMID: 14754897) Huang J … Shu HB (The Journal of biological chemistry 2004) 3 4 60
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for ZFAND5 Gene

Sources for ZFAND5 Gene

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