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ZFAND5 Gene

protein-coding   GIFtS: 54
GCID: GC09M074966

Zinc Finger, AN1-Type Domain 5

(Previous names: zinc finger protein 216, zinc finger, A20 domain containing...)
(Previous symbols: ZNF216, ZA20D2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, AN1-Type Domain 51 2     Zinc Finger, A20 Domain Containing 21 2
ZNF2161 2 3 5     Zinc Finger A20 Domain-Containing Protein 22 3
Zinc Finger Protein 2161 2 3     ZFAND5A2
ZA20D21 2 3     AN1-Type Zinc Finger Protein 52

External Ids:    HGNC: 130081   Entrez Gene: 77632   Ensembl: ENSG000001073727   OMIM: 6047615   UniProtKB: O760803   

Export aliases for ZFAND5 gene to outside databases

Previous GC identifers: GC09M074159 GC09M044789


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZFAND5 Gene:
ZFAND5 (zinc finger, AN1-type domain 5) is a protein-coding gene. Diseases associated with ZFAND5 include labyrinthitis, and rhabdomyosarcoma. An important paralog of this gene is ZFAND6.

UniProtKB/Swiss-Prot: ZFAN5_HUMAN, O76080
Function: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated
proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a
role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by
overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and
TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced
apoptosis. Is a potent inhibitory factor for osteoclast differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFAND5 gene promoter:
         TBP   POU2F1   Egr-1   POU2F1a   TFIID   Lmo2   Sox9   AP-2gamma   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFAND5 promoter sequence
   Search Chromatin IP Primers for ZFAND5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFAND5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q13-q21   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q13-q21

ZFAND5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFAND5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M074966:  view genomic region     (about GC identifiers)

Start:
74,966,341 bp from pter      End:
74,980,163 bp from pter
Size:
13,823 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZFAN5_HUMAN, O76080 (See protein sequence)
Recommended Name: AN1-type zinc finger protein 5  
Size: 213 amino acids; 23132 Da
Subunit: Interacts with ubiquitin and polyubiquitinated proteins. Identified in a heterotrimeric complex with
ubiquitin and SQSTM1, where ZFAND5 and SQSTM1 both interact with the same ubiquitin molecule (By similarity).
Homooligomer and/or heterooligomer. Interacts (via A20-type domain) with IKBKG and RIPK1 and with TRAF6 (via
AN1-type domain)
Secondary accessions: A8K484

Explore the universe of human proteins at neXtProt for ZFAND5: NX_O76080

Explore proteomics data for ZFAND5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys86, Lys183, Lys191
  • Modification sites at PhosphoSitePlus

  • See ZFAND5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001095890.1  NP_001095891.1  NP_001265172.1  NP_001265173.1  NP_001265174.1  NP_005998.1  

    ENSEMBL proteins: 
     ENSP00000366161   ENSP00000366159   ENSP00000350586   ENSP00000366155   ENSP00000237937  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFAND: Zinc fingers, AN1-type domain containing

    2 InterPro protein domains:
     IPR000058 Znf_AN1
     IPR002653 Znf_A20

    Graphical View of Domain Structure for InterPro Entry O76080

    ProtoNet protein and cluster: O76080

    2 Blocks protein domains:
    IPB000058 Zn-finger
    IPB002653 Zn-finger


    UniProtKB/Swiss-Prot: ZFAN5_HUMAN, O76080
    Domain: The A20-type zinc finger directly binds polyubiquitin chains and associates with the 26S proteasome. The
    zinc-finger A20-type domain is essential for inhibition of NF-kappa-B activation (By similarity)
    Similarity: Contains 1 A20-type zinc finger
    Similarity: Contains 1 AN1-type zinc finger


    ZFAND5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZFAN5_HUMAN, O76080
    Function: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated
    proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a
    role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by
    overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and
    TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced
    apoptosis. Is a potent inhibitory factor for osteoclast differentiation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI16424905
    GO:0008270zinc ion binding IEA--
         
    ZFAND5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZFAND5:
     Increased G1 DNA content 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zfand5):
     adipose tissue  cardiovascular system  cellular  craniofacial  growth/size/body 
     homeostasis/metabolism  mortality/aging  muscle  respiratory system  skeleton 

    ZFAND5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZFAND5
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    miRNA
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    miRTarBase miRNAs that target ZFAND5:
    hsa-mir-19b-3p (MIRT031245), hsa-mir-769-3p (MIRT039136), hsa-mir-15b-5p (MIRT046522), hsa-mir-320a (MIRT044762), hsa-let-7e-5p (MIRT051626), hsa-mir-18a-5p (MIRT031311), hsa-mir-98-5p (MIRT027817)

    Block miRNA regulation of human, mouse, rat ZFAND5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFAND5 (see all 183):
    hsa-miR-100* hsa-miR-3653 hsa-miR-4275 hsa-miR-877* hsa-miR-298 hsa-miR-200b hsa-miR-509-3-5p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidZFAND5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZFAND5

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    GenScript: all cDNA clones in your preferred vector (see all 3): ZFAND5 (NM_001102421)
    Sino Biological Human cDNA Clone for ZFAND5
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZFAN5_HUMAN, O76080: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm IEA--

    ZFAND5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZFAND5 About    
    See pathways by source

    SuperPathContained pathways About
    1TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    2FoxO family signaling
    FoxO family signaling


    2 BioSystems Pathways for ZFAND5
        TNF-alpha/NF-kB Signaling Pathway
    FoxO family signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFAND5
    Interactions:

        Search GeneGlobe Interaction Network for ZFAND5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for ZFAND5 (O760801, 2, 3 ENSP000002379374) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMD6Q150082, 3, ENSP000002959014MINT-1959040 I2D: score=2 STRING: ENSP00000295901
    UBCP0CG481, 2, 3, ENSP000003448184EBI-8028844,EBI-3390054 MINT-1958898 MINT-1958929 MINT-1958963 I2D: score=1 STRING: ENSP00000344818
    RAD23BP547272, 3, ENSP000003507084MINT-1977998 I2D: score=2 STRING: ENSP00000350708
    TNFAIP3P215803, ENSP000002372894I2D: score=3 STRING: ENSP00000237289
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=4 STRING: ENSP00000358622
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001944vasculature development IEA--
    GO:0003016respiratory system process IEA--
    GO:0008150biological_process ND--
    GO:0010761fibroblast migration IEA--

    ZFAND5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFAND5 (ZFAN5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZFAND5 gene (6 alternative transcripts): 
    NM_001102420.2  NM_001102421.2  NM_001278243.1  NM_001278244.1  NM_001278245.1  NM_006007.3  

    Unigene Cluster for ZFAND5:

    Zinc finger, AN1-type domain 5
    Hs.406096  [show with all ESTs]
    Unigene Representative Sequence: NM_001102420
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488164 ENST00000376962 ENST00000376960 ENST00000343431 ENST00000471197
    ENST00000376956 ENST00000487330 ENST00000237937(uc010mox.1 uc010moy.1 uc004aix.2 uc004aiw.2 uc004aiy.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat ZFAND5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFAND5 (see all 183):
    hsa-miR-100* hsa-miR-3653 hsa-miR-4275 hsa-miR-877* hsa-miR-298 hsa-miR-200b hsa-miR-509-3-5p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidZFAND5 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZFAND5
      QuantiFast Probe-based Assays in human, mouse, rat ZFAND5

    Additional mRNA sequence: 

    AF062346.1 AF062347.1 AK025782.1 AK290849.1 AK307376.1 BC011018.1 BC027707.2 BC073131.1 
    BX648551.1 BX649046.1 X75687.1 

    Selected DOTS entries (see all 44):

    DT.449625  DT.99986394  DT.92007842  DT.95078895  DT.100846038  DT.121193093  DT.210220  DT.121193065 
    DT.121193046  DT.215241  DT.100846050  DT.101971278  DT.75119387  DT.121193186  DT.99944019  DT.100745043 
    DT.121193016  DT.121193129  DT.100846043  DT.100846048  DT.95078891  DT.95078899  DT.95085345  DT.121193157 

    Selected AceView cDNA sequences (see all 737):

    BQ008880 CA425621 T35613 CR624137 AA974076 AA976522 BM677902 CD677464 
    CR619628 F01856 CB129880 AF062347 AA278973 BM673681 AI421363 BP375697 
    N26016 AI382512 CA748687 BE005734 BG057321 CB155401 BM994178 BU619236 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c
    SP1:              -                     
    SP2:                                    
    SP3:        -     -                     


    ECgene alternative splicing isoforms for ZFAND5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ZFAND5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGAGGGA
    ZFAND5 Expression
    About this image


    ZFAND5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    ZFAND5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFAND5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406096

    UniProtKB/Swiss-Prot: ZFAN5_HUMAN, O76080
    Tissue specificity: Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant
    brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor.
    Weakly expressed or undetectable in adult brain, heart, colon, thymus, spleen, kidney, liver, small intestine,
    placenta, lung and peripheral blood leukocytes. Expressed in rhabdomyosarcoma RD cells (at protein level)

        Custom PCR Arrays for ZFAND5
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZFAND5 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfand51 , 5 zinc finger, AN1-type domain 51, 5 96.71(n)1
    98.59(a)1
      19 (14.32 cM)5
    226821  NM_009551.51  NP_033577.11 
     212722785 
    chicken
    (Gallus gallus)
    Aves ZFAND51 zinc finger, AN1-type domain 5 89.26(n)
    93.84(a)
      427254  NM_001031424.1  NP_001026595.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZFAND56
    zinc finger, AN1-type domain 5
    92(a)
    1 ↔ 1
    2(48154079-48165883)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.120072 Xenopus laevis transcribed sequence with moderate similarity more 86.66(n)    CD300860.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059673.12   -- 76.76(n)    BC059673.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG436746
    CG153686
    --
    40(a)
    26(a)
    many ↔ many
    many ↔ many
    3R(5165938-5188666)
    X(9109912-9110400)
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_F22D6.21 CELE_F22D6.2 49.91(n)
    42.25(a)
      172441  NM_059604.5  NP_492005.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07930001 Os03g0793000 49.2(n)
    49.66(a)
      4334393  NM_001058063.1  NP_001051528.1 


    ENSEMBL Gene Tree for ZFAND5 (if available)
    TreeFam Gene Tree for ZFAND5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZFAND5 gene
    ZFAND62  
    2 SIMAP similar genes for ZFAND5 using alignment to 2 protein entries:     ZFAN5_HUMAN (see all proteins):
    ZFAND6    LOC158381

    ZFAND5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZFAND5
    PGOHUM00000250577 PGOHUM00000243638


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFAND5 (see all 406)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs678498231,2
    C--44792399(+) AGCAA-/CAGTTGC 3 -- ut312Minor allele frequency- CA:0.25NA 4
    rs1883108781,2
    --74965855(+) ACCAGA/CCAACA 3 -- int10--------
    rs78680021,2
    C,F,H--74965861(+) CAACAT/CTTTTA 3 -- int16Minor allele frequency- C:0.01NS EA WA 540
    rs111432721,2
    C,F,H--74965908(+) AAATTT/CACCCA 3 -- int16Minor allele frequency- C:0.04NS EA CSA WA 540
    rs1807137091,2
    --74965969(+) TTCCTA/GGCTGA 3 -- int10--------
    rs1432611401,2
    C--74966004(+) CTTAAA/TGTTAT 3 -- int10--------
    rs1864995031,2
    --74966293(+) TGGCAC/TTTAGC 3 -- int10--------
    rs1401057431,2
    C--74966505(+) TTGTA-/ACTT  
     T
    /CTTTT
    CTTTT
    6 -- ut310--------
    rs719419571,2
    C--74966507(+) GTACT-/TTTACT
            
    TTTTT
    3 -- cds10--------
    rs713575581,2
    C,F--74966509(+) ACTTT-/AC/AC 
    TT
    /ACTTT
    TTTTT
    9 -- ut312NA CSA 4

    HapMap Linkage Disequilibrium report for ZFAND5 (74966341 - 74980163 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZFAND5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFAND5
    DNA2.0 Custom Variant and Variant Library Synthesis for ZFAND5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604761    OMIM disorders: --

    4 diseases for ZFAND5:    
    About MalaCards
    labyrinthitis    rhabdomyosarcoma    pancreatitis    cerebritis


    ZFAND5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZFAND5
    Human Genome Epidemiology (HuGE) Navigator: ZFAND5 (3 documents)

    Export disorders for ZFAND5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFAND5 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with ZFAND5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. (PubMed id 9758550)1, 2, 3 Scott D.A....Sheffield V.C. (Gene 1998)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. ZNF216 is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation. (PubMed id 14754897)1, 2 Huang J....Shu H.-B. (J. Biol. Chem. 2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. The protein Zfand5 binds and stabilizes mRNAs with AU-rich elements in their 3'-untranslated regions. (PubMed id 22665488)1 He G....Ding A. (J. Biol. Chem. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Independent interactions of ubiquitin-binding domains in a ubiquitin- mediated ternary complex. (PubMed id 21923101)1 Garner T.P.... Searle M.S. (Biochemistry 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7763 HGNC: 13008 AceView: ZA20D2 Ensembl:ENSG00000107372 euGenes: HUgn7763
    ECgene: ZFAND5 H-InvDB: ZFAND5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZFAND5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFAND5 gene:
    Search GeneIP for patents involving ZFAND5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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