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Aliases for ZFAND5 Gene

Aliases for ZFAND5 Gene

  • Zinc Finger, AN1-Type Domain 5 2 3
  • Zinc Finger Protein 216 2 3 4
  • ZNF216 3 4 6
  • Zinc Finger A20 Domain-Containing Protein 2 3 4
  • Zinc Finger, A20 Domain Containing 2 2 3
  • ZA20D2 3 4
  • AN1-Type Zinc Finger Protein 5 3
  • ZFAND5A 3

External Ids for ZFAND5 Gene

Previous Symbols for ZFAND5 Gene

  • ZNF216
  • ZA20D2

Summaries for ZFAND5 Gene

GeneCards Summary for ZFAND5 Gene

ZFAND5 (Zinc Finger, AN1-Type Domain 5) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway and FoxO family signaling. An important paralog of this gene is ZFAND6.

UniProtKB/Swiss-Prot for ZFAND5 Gene

  • Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND5 Gene

Genomics for ZFAND5 Gene

Genomic Location for ZFAND5 Gene

Start:
72,351,425 bp from pter
End:
72,365,247 bp from pter
Size:
13,823 bases
Orientation:
Minus strand

Genomic View for ZFAND5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFAND5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND5 Gene

Regulatory Elements for ZFAND5 Gene

Proteins for ZFAND5 Gene

  • Protein details for ZFAND5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76080-ZFAN5_HUMAN
    Recommended name:
    AN1-type zinc finger protein 5
    Protein Accession:
    O76080
    Secondary Accessions:
    • A8K484

    Protein attributes for ZFAND5 Gene

    Size:
    213 amino acids
    Molecular mass:
    23132 Da
    Quaternary structure:
    • Interacts with ubiquitin and polyubiquitinated proteins. Identified in a heterotrimeric complex with ubiquitin and SQSTM1, where ZFAND5 and SQSTM1 both interact with the same ubiquitin molecule (By similarity). Homooligomer and/or heterooligomer. Interacts (via A20-type domain) with IKBKG and RIPK1 and with TRAF6 (via AN1-type domain).

neXtProt entry for ZFAND5 Gene

Proteomics data for ZFAND5 Gene at MOPED

Post-translational modifications for ZFAND5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys86, Lys183, and Lys191

No data available for DME Specific Peptides for ZFAND5 Gene

Domains for ZFAND5 Gene

Gene Families for ZFAND5 Gene

HGNC:
  • ZFAND :Zinc fingers, AN1-type domain containing

Protein Domains for ZFAND5 Gene

UniProtKB/Swiss-Prot:

ZFAN5_HUMAN
Domain:
  • The A20-type zinc finger directly binds polyubiquitin chains and associates with the 26S proteasome. The zinc-finger A20-type domain is essential for inhibition of NF-kappa-B activation (By similarity).:
    • O76080
Similarity:
  • Contains 1 A20-type zinc finger.:
    • O76080
  • Contains 1 AN1-type zinc finger.:
    • O76080
genes like me logo Genes that share domains with ZFAND5: view

Function for ZFAND5 Gene

Molecular function for ZFAND5 Gene

UniProtKB/Swiss-Prot Function: Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.

Gene Ontology (GO) - Molecular Function for ZFAND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16424905
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZFAND5: view
genes like me logo Genes that share phenotypes with ZFAND5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFAND5 Gene

Localization for ZFAND5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFAND5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFAND5 Gene COMPARTMENTS Subcellular localization image for ZFAND5 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ZFAND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZFAND5: view

Pathways for ZFAND5 Gene

genes like me logo Genes that share pathways with ZFAND5: view

Pathways by source for ZFAND5 Gene

2 BioSystems pathways for ZFAND5 Gene

Gene Ontology (GO) - Biological Process for ZFAND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001944 vasculature development IEA --
GO:0003016 respiratory system process IEA --
GO:0008150 biological_process ND --
GO:0010761 fibroblast migration IEA --
genes like me logo Genes that share ontologies with ZFAND5: view

Transcripts for ZFAND5 Gene

Unigene Clusters for ZFAND5 Gene

Zinc finger, AN1-type domain 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: - -

Relevant External Links for ZFAND5 Gene

GeneLoc Exon Structure for
ZFAND5
ECgene alternative splicing isoforms for
ZFAND5

Expression for ZFAND5 Gene

mRNA expression in normal human tissues for ZFAND5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZFAND5 Gene

This gene is overexpressed in Muscle - Skeletal (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFAND5 Gene

SOURCE GeneReport for Unigene cluster for ZFAND5 Gene Hs.406096

mRNA Expression by UniProt/SwissProt for ZFAND5 Gene

O76080-ZFAN5_HUMAN
Tissue specificity: Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly expressed or undetectable in adult brain, heart, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Expressed in rhabdomyosarcoma RD cells (at protein level).
genes like me logo Genes that share expressions with ZFAND5: view

Orthologs for ZFAND5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZFAND5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFAND5 36
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia ZFAND5 36
  • 97.18 (n)
  • 98.59 (a)
ZFAND5 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFAND5 36
  • 97.18 (n)
  • 100 (a)
ZFAND5 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfand5 36
  • 96.71 (n)
  • 98.59 (a)
Zfand5 16
Zfand5 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFAND5 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFAND5 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfand5 36
  • 96.46 (n)
  • 98.23 (a)
chicken
(Gallus gallus)
Aves ZFAND5 36
  • 89.26 (n)
  • 93.84 (a)
ZFAND5 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFAND5 37
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12007 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6493 36
zfand5 36
  • 82.94 (n)
  • 89.57 (a)
zebrafish
(Danio rerio)
Actinopterygii zfand5a 37
  • 65 (a)
OneToMany
zfand5b 36
  • 68.25 (n)
  • 70.95 (a)
zfand5b 37
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15368 37
  • 26 (a)
ManyToMany
CG43674 37
  • 40 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_F22D6.2 36
  • 49.91 (n)
  • 42.25 (a)
F22D6.2 37
  • 42 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os03g0793000 36
  • 49.2 (n)
  • 49.66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11284 36
Species with no ortholog for ZFAND5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFAND5 Gene

ENSEMBL:
Gene Tree for ZFAND5 (if available)
TreeFam:
Gene Tree for ZFAND5 (if available)

Paralogs for ZFAND5 Gene

Paralogs for ZFAND5 Gene

Selected SIMAP similar genes for ZFAND5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZFAND5 Gene

genes like me logo Genes that share paralogs with ZFAND5: view

Variants for ZFAND5 Gene

Sequence variations from dbSNP and Humsavar for ZFAND5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs969 -- 72,354,948(+) AGTGG(C/T)GCTGG utr-variant-3-prime
rs3398 -- 72,354,160(+) GAATT(A/G)TCATA utr-variant-3-prime
rs6715 -- 72,354,666(-) GCACT(A/C)CTTCT utr-variant-3-prime
rs909173 -- 72,362,597(-) TTGTT(A/G)TCTCT intron-variant
rs909174 -- 72,362,541(-) ACAAA(G/T)ATTTT intron-variant

Relevant External Links for ZFAND5 Gene

HapMap Linkage Disequilibrium report
ZFAND5

No data available for Structural Variations from Database of Genomic Variants (DGV) for ZFAND5 Gene

Disorders for ZFAND5 Gene

Relevant External Links for ZFAND5

Genetic Association Database (GAD)
ZFAND5
Human Genome Epidemiology (HuGE) Navigator
ZFAND5
genes like me logo Genes that share disorders with ZFAND5: view

No data available for UniProtKB/Swiss-Prot for ZFAND5 Gene

Publications for ZFAND5 Gene

  1. Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. (PMID: 9758550) Scott D.A. … Sheffield V.C. (Gene 1998) 2 3 4
  2. ZNF216 is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation. (PMID: 14754897) Huang J. … Shu H.-B. (J. Biol. Chem. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49

Products for ZFAND5 Gene

Sources for ZFAND5 Gene

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