Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZFAND4 Gene

Aliases for ZFAND4 Gene

  • Zinc Finger AN1-Type Containing 4 2 3 5
  • AN1-Type Zinc Finger And Ubiquitin Domain-Containing Protein-Like 1 3 4
  • Zinc Finger, AN1-Type Domain 4 2 3
  • ANUBL1 3 4
  • AN1-Type Zinc Finger And Ubiquitin Domain-Containing Protein 1 3
  • AN1, Ubiquitin-Like, Homolog (Xenopus Laevis) 2
  • AN1-Type Zinc Finger Protein 4 3
  • AN1, Ubiquitin-Like, Homolog 3

External Ids for ZFAND4 Gene

Previous HGNC Symbols for ZFAND4 Gene

  • ANUBL1

Previous GeneCards Identifiers for ZFAND4 Gene

  • GC10M046112

Summaries for ZFAND4 Gene

GeneCards Summary for ZFAND4 Gene

ZFAND4 (Zinc Finger AN1-Type Containing 4) is a Protein Coding gene. An important paralog of this gene is ZFAND5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND4 Gene

Genomics for ZFAND4 Gene

Regulatory Elements for ZFAND4 Gene

Enhancers for ZFAND4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F045726 0.2 ENCODE 19.3 -54.4 -54367 1.5 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 ZNF2 CBX5 ZNF207 FOS PARGP1 WASHC2C AGAP4 ZFAND4 LOC105378289 AGAP10P C10orf10 FAM35BP ALOX5 FAM21FP
GH10F045671 1 ENCODE 19.1 +0.1 123 2.2 PKNOX1 ATF1 ARID4B SIN3A FEZF1 ZNF48 ZNF2 YY1 GLIS2 ZNF143 ZFAND4 MARCH8 WASHC2C
GH10F045575 0.4 ENCODE 18.6 +97.2 97196 0.5 PKNOX1 TAL1 ZBTB40 TEAD3 RARA ZNF316 GATAD1 NCOR1 HNF4G NFE2 ZFAND4 MARCH8 GC10P045511
GH10F045579 1.1 Ensembl ENCODE 18.3 +91.9 91917 3.3 HDAC1 PKNOX1 WRNIP1 ZNF766 FOS ZNF362 CEBPB ZEB2 PBX2 THRAP3 ZFAND4 MARCH8 PARGP1 WASHC2C AGAP4 GC10P045511
GH10F045710 0.5 Ensembl 17.4 -37.6 -37627 0.8 MTA2 EBF1 RELA ZFAND4 OR13A1 PIR33317 PIR42015
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZFAND4 on UCSC Golden Path with GeneCards custom track

Promoters for ZFAND4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000354292 462 1801 PKNOX1 ATF1 ARID4B SIN3A FEZF1 ZNF48 ZNF2 YY1 GLIS2 ZNF143

Genomic Location for ZFAND4 Gene

Chromosome:
10
Start:
45,614,567 bp from pter
End:
45,672,962 bp from pter
Size:
58,396 bases
Orientation:
Minus strand

Genomic View for ZFAND4 Gene

Genes around ZFAND4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND4 Gene

Proteins for ZFAND4 Gene

  • Protein details for ZFAND4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XD8-ZFAN4_HUMAN
    Recommended name:
    AN1-type zinc finger protein 4
    Protein Accession:
    Q86XD8
    Secondary Accessions:
    • A8K8V4
    • B2RAX2
    • Q5VVY5

    Protein attributes for ZFAND4 Gene

    Size:
    727 amino acids
    Molecular mass:
    80358 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZFAND4 Gene

Post-translational modifications for ZFAND4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZFAND4 Gene

Domains & Families for ZFAND4 Gene

Gene Families for ZFAND4 Gene

Protein Domains for ZFAND4 Gene

Graphical View of Domain Structure for InterPro Entry

Q86XD8

UniProtKB/Swiss-Prot:

ZFAN4_HUMAN :
  • Contains 1 ubiquitin-like domain.
  • Contains 1 AN1-type zinc finger.
Domain:
  • Contains 1 ubiquitin-like domain.
Similarity:
  • Contains 1 AN1-type zinc finger.
genes like me logo Genes that share domains with ZFAND4: view

Function for ZFAND4 Gene

Gene Ontology (GO) - Molecular Function for ZFAND4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFAND4: view
genes like me logo Genes that share phenotypes with ZFAND4: view

Animal Model Products

miRNA for ZFAND4 Gene

miRTarBase miRNAs that target ZFAND4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND4 Gene

Localization for ZFAND4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFAND4 Gene COMPARTMENTS Subcellular localization image for ZFAND4 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZFAND4 Gene

Pathways & Interactions for ZFAND4 Gene

SuperPathways for ZFAND4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZFAND4 Gene

Transcripts for ZFAND4 Gene

Unigene Clusters for ZFAND4 Gene

Zinc finger, AN1-type domain 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a ·
SP1: - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - -
SP6:
SP7: - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - -
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - - - - - -
SP13: - -
SP14: - - - - - - - - -
SP15: - - - - -
SP16:
SP17: - - -
SP18: - - - - - - - - - - -
SP19:

ExUns: 13b · 13c ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16: - - - - -
SP17:
SP18:
SP19:

Relevant External Links for ZFAND4 Gene

GeneLoc Exon Structure for
ZFAND4
ECgene alternative splicing isoforms for
ZFAND4

Expression for ZFAND4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFAND4 Gene

mRNA differential expression in normal tissues according to GTEx for ZFAND4 Gene

This gene is overexpressed in Testis (x10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZFAND4 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZFAND4 Gene:

ZFAND4

SOURCE GeneReport for Unigene cluster for ZFAND4 Gene:

Hs.89029
genes like me logo Genes that share expression patterns with ZFAND4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZFAND4 Gene

Orthologs for ZFAND4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFAND4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANUBL1 34
  • 99.27 (n)
ZFAND4 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFAND4 34 35
  • 87.45 (n)
cow
(Bos Taurus)
Mammalia ZFAND4 34
  • 84.98 (n)
ANUBL1 35
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfand4 34
  • 81.25 (n)
mouse
(Mus musculus)
Mammalia Zfand4 34 16 35
  • 80.83 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFAND4 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 67 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZFAND4 34 35
  • 70 (n)
lizard
(Anolis carolinensis)
Reptilia ZFAND4 35
  • 16 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100144290 34
  • 73.67 (n)
Str.20232 34
African clawed frog
(Xenopus laevis)
Amphibia LOC397781 34
zebrafish
(Danio rerio)
Actinopterygii zfand4 34 35
  • 56.45 (n)
Dr.15582 34
fruit fly
(Drosophila melanogaster)
Insecta RpL40 35
  • 40 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL40A 35
  • 36 (a)
ManyToMany
RPL40B 35
  • 36 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToMany
-- 35
  • 22 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.488 34
Species where no ortholog for ZFAND4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFAND4 Gene

ENSEMBL:
Gene Tree for ZFAND4 (if available)
TreeFam:
Gene Tree for ZFAND4 (if available)

Paralogs for ZFAND4 Gene

Paralogs for ZFAND4 Gene

(8) SIMAP similar genes for ZFAND4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZFAND4: view

Variants for ZFAND4 Gene

Sequence variations from dbSNP and Humsavar for ZFAND4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1060848 -- 45,616,502(-) AAGAG(C/T)GCAGG nc-transcript-variant, reference, synonymous-codon
rs1072929 -- 45,635,229(-) ttttt(G/T)tttgt intron-variant
rs10736836 -- 45,620,223(+) TCACA(C/T)CTGTA intron-variant
rs1075000 -- 45,635,520(-) attta(G/T)atttg intron-variant
rs10751385 -- 45,623,209(+) TATGA(C/T)GGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFAND4 Gene

Variant ID Type Subtype PubMed ID
dgv2e24 CNV gain 17666407
esv3623100 CNV loss 21293372
esv3623101 CNV loss 21293372
esv3623102 CNV loss 21293372
esv3623103 CNV gain 21293372
esv3891797 CNV gain 25118596
nsv1137917 CNV deletion 24896259
nsv947910 CNV duplication 23825009

Variation tolerance for ZFAND4 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.53; 82.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFAND4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFAND4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND4 Gene

Disorders for ZFAND4 Gene

Relevant External Links for ZFAND4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFAND4

No disorders were found for ZFAND4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND4 Gene

Publications for ZFAND4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer. (PMID: 25682742) Tang L. … Dong W.F. (Oncol. Rep. 2015) 3 64
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64

Products for ZFAND4 Gene

Sources for ZFAND4 Gene

Content
Loading form....