ZFAND4 Gene
protein-coding GIFtS: 44
GCID: GC10M046112
|
|
zinc finger, AN1-type domain 4(Previous names: AN1, ubiquitin-like, homolog (Xenopus laevis) )
(Previous symbol: ANUBL1)
| |
Aliases
for ZFAND4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, AN1-Type Domain 41 2 | | AN1, Ubiquitin-Like, Homolog (Xenopus Laevis)1 | | ANUBL11 2 3 | | AN1, Ubiquitin-Like, Homolog2 | | AN1-Type Zinc Finger And Ubiquitin Domain-Containing Protein-Like 12 3 | | AN1-Type Zinc Finger And Ubiquitin Domain-Containing Protein 12 | | FLJ401851 | | AN1-Type Zinc Finger Protein 42 |
Export aliases for ZFAND4 gene to outside databases |
Summaries
for ZFAND4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZFAND4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_033985.7
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZFAND4
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZFAND4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFAND4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.22 Ensembl cytogenetic band: 10q11.22 HGNC cytogenetic band: 10q11.22ZFAND4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M046112: view genomic region
(about GC identifiers)
Start:
|
46,111,039 bp from pter |
End:
|
46,168,251 bp from pter |
Size:
|
57,213 bases |
Orientation:
|
minus strand |
|
Proteins
for ZFAND4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZFAN4_HUMAN, Q86XD8 (See
protein sequence)Recommended Name: AN1-type zinc finger protein 4 Size: 727 amino acids; 80358 Da
Secondary accessions: A8K8V4 B2RAX2 Q5VVY5Explore the universe of human proteins at neXtProt for ZFAND4: NX_Q86XD8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86XD8
ZFAND4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001121796.1 NP_777550.2
ENSEMBL proteins: ENSP00000339484 ENSP00000363491 ENSP00000363490 ENSP00000434854 ENSP00000335586 ENSP00000363486
Human Recombinant Protein Products:
ZFAND4 Antibody Products:
Assay Products for ZFAND4: |
Protein
Domains /
Families
for ZFAND4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZFAND4 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86XD8ProtoNet protein and cluster: Q86XD8 2 Blocks protein families: IPB000058 Zn-finger IPB000626 Ubiquitin domain
UniProtKB/Swiss-Prot: ZFAN4_HUMAN, Q86XD8Similarity: Contains 1 AN1-type zinc fingerSimilarity: Contains 1 ubiquitin-like domain |
Function
for ZFAND4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZFAND4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFAND4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
ZFAND4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZFAND4:
|
Pathways & Interactions
for ZFAND4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFAND4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZFAND4 (ENSP000003394844) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZFAND4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZFAND4
Search CenterWatch for drugs/clinical trials and news about ZFAND4 / ZFAN4
|
Transcripts
for ZFAND4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZFAND4 gene (2 alternative transcripts): NM_001128324.1 NM_174890.2 Unigene Cluster for ZFAND4: Zinc finger, AN1-type domain 4 Hs.89029 [show with all ESTs]Unigene Representative Sequence: NM_1748909 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000344646(uc001jcl.4 uc001jcp.4 uc001jcm.4) ENST00000374371(uc001jco.4)
ENST00000374370 ENST00000484333 ENST00000465407(uc001jcq.2) ENST00000495747
ENST00000497028 ENST00000335258(uc001jcr.2) ENST00000374366(uc009xmu.3 uc001jcn.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for ZFAND4 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZFAND4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFAND4 |
Additional cDNA sequence: AF311324.1 AK090704.1 AK097504.1 AK097924.1 AK292420.1 AK292469.1 AK314395.1 BC017591.1 BC045587.1 BC048968.1 21 DOTS entries: DT.40249000 DT.95262980 DT.308642 DT.95162998 DT.95142627 DT.95163001 DT.95245892 DT.312737 DT.312733 DT.99930514 DT.95121328 DT.100787069 DT.100844966 DT.121246834 DT.100787070 DT.121246795 DT.92420829 DT.100740560 DT.100787072 DT.121246824 DT.70101282 24/90 AceView cDNA sequences (see all 90): BQ722041 BQ889116 AA151557 AI655960 BC045587 BX111939 AA830491 AA908268 BM795247 AW074113 AA746289 AA813850 CD243635 AK090704 AV691310 Z24875 AX746581 AI125747 BC048968 BI463308 BQ438343 BQ429078 AK097924 BU568627
GeneLoc Exon Structure
5/19 Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND4 (see all 19) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | |
| ExUns: | 13b | · | 13c | ^ | 14a | · | 14b | · | 14c | · | 14d | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b |
|---|
|
| SP1: | | | | | - | | | | - | | - | | | | | | | | - | | | | | | |
| SP2: | | | | | - | | | | - | | - | | | | | | | | - | | | | | | |
| SP3: | | | | | - | | | | - | | - | | | | | | | | - | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | - | | - | | | | - | | | | | | |
| SP5: | | | | | - | | | | - | | - | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for ZFAND4
|
Expression
for ZFAND4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZFAND4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAGTGTATA
About this image
See ZFAND4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZFAND4
SOURCE GeneReport for Unigene cluster: Hs.89029
SABiosciences Custom PCR Arrays for ZFAND4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFAND4
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ZFAND4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFAND4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFAND4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND4 |
Orthologs
for ZFAND4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZFAND4 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Zfand41 , 5 |
AN1, ubiquitin-like, homolog (Xenopus laevis)5
zinc finger, AN1-type domain 41 |
80.74(n)1
74.07(a)1 |
|
6 (53.77 cM)5
674921 NM_001081317.11 NP_001074786.11
1162642225 |
chicken
(Gallus gallus) |
Aves |
ANUBL11 |
AN1, ubiquitin-like, homolog (Xenopus laevis) |
70(n)
62.03(a) |
|
423771 XM_003641513.1 XP_003641561.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ANUBL16 |
-- |
39(a) |
1 ↔ 1 |
GL343297.1(331767-347727) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3977812 |
ubiquitin-like fusion protein |
73.95(n) |
|
L08475.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.155822 |
Transcribed sequence with weak similarity to protein more |
71.65(n) |
|
57043844 |
ENSEMBL Gene Tree for ZFAND4 (if available)
TreeFam Gene Tree for ZFAND4 (if available) |
Paralogs
for ZFAND4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZFAND4 gene
- ZFAND52 ZFAND62
7 SIMAP similar genes for ZFAND4 using alignment to 6 protein entries: ZFAN4_HUMAN (see all proteins):ANUBL1 UBBP4 UBA52 RPS27A UBC NEDD8
UBB
ZFAND4 for paralogs About GeneDecksing
|
Genomic Variants
for ZFAND4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZFAND4 (46111039 - 46168251 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZFAND4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFAND4 |
|
Disorders
/ Diseases
for ZFAND4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZFAND4 for disorders About GeneDecksing
2  diseases for ZFAND4: About MalaCardsalzheimer's disease malaria
Export disorders for ZFAND4 gene to outside databases
|
Publications
for ZFAND4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZFAND4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZFAND4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZFAND4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZFAND4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZFAND4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZFAND4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZFAND4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZFAND4 gene:
Search GeneIP for patents involving ZFAND4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZFAND4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZFAND4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFAND4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFAND4 | | | OriGene Protein Over-expression Lysate for ZFAND4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZFAND4 | | OriGene 3'-UTR Clone for ZFAND4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |  |  |  |  | | | | |
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 | | | ZFAND4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND4 |
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