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Aliases for ZFAND4 Gene

Aliases for ZFAND4 Gene

  • Zinc Finger, AN1-Type Domain 4 2 3
  • AN1-Type Zinc Finger And Ubiquitin Domain-Containing Protein-Like 1 3 4
  • ANUBL1 3 4
  • AN1-Type Zinc Finger And Ubiquitin Domain-Containing Protein 1 3
  • AN1, Ubiquitin-Like, Homolog (Xenopus Laevis) 2
  • AN1-Type Zinc Finger Protein 4 3
  • AN1, Ubiquitin-Like, Homolog 3

External Ids for ZFAND4 Gene

Previous Symbols for ZFAND4 Gene

  • ANUBL1

Summaries for ZFAND4 Gene

GeneCards Summary for ZFAND4 Gene

ZFAND4 (Zinc Finger, AN1-Type Domain 4) is a Protein Coding gene. An important paralog of this gene is UBB.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND4 Gene

Genomics for ZFAND4 Gene

Genomic Location for ZFAND4 Gene

Start:
45,615,501 bp from pter
End:
45,672,813 bp from pter
Size:
57,313 bases
Orientation:
Minus strand

Genomic View for ZFAND4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFAND4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND4 Gene

No data available for Regulatory Elements for ZFAND4 Gene

Proteins for ZFAND4 Gene

  • Protein details for ZFAND4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XD8-ZFAN4_HUMAN
    Recommended name:
    AN1-type zinc finger protein 4
    Protein Accession:
    Q86XD8
    Secondary Accessions:
    • A8K8V4
    • B2RAX2
    • Q5VVY5

    Protein attributes for ZFAND4 Gene

    Size:
    727 amino acids
    Molecular mass:
    80358 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZFAND4 Gene

Proteomics data for ZFAND4 Gene at MOPED

Post-translational modifications for ZFAND4 Gene

No Post-translational modifications

Other Protein References for ZFAND4 Gene

No data available for DME Specific Peptides for ZFAND4 Gene

Domains for ZFAND4 Gene

Gene Families for ZFAND4 Gene

HGNC:
  • ZFAND :Zinc fingers, AN1-type domain containing

Protein Domains for ZFAND4 Gene

UniProtKB/Swiss-Prot:

ZFAN4_HUMAN
Domain:
  • Contains 1 ubiquitin-like domain.:
    • Q86XD8
Similarity:
  • Contains 1 AN1-type zinc finger.:
    • Q86XD8
genes like me logo Genes that share domains with ZFAND4: view

Function for ZFAND4 Gene

Gene Ontology (GO) - Molecular Function for ZFAND4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZFAND4: view

Phenotypes for ZFAND4 Gene

GenomeRNAi human phenotypes for ZFAND4:
genes like me logo Genes that share phenotypes with ZFAND4: view

miRNA for ZFAND4 Gene

miRTarBase miRNAs that target ZFAND4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFAND4 Gene

Localization for ZFAND4 Gene

No data available for Gene Ontology (GO) - Cellular Components for ZFAND4 Gene

Pathways for ZFAND4 Gene

SuperPathways for ZFAND4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND4 Gene

None

No data available for Pathways by source for ZFAND4 Gene

Transcripts for ZFAND4 Gene

Unigene Clusters for ZFAND4 Gene

Zinc finger, AN1-type domain 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a ·
SP1: - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - -
SP6:
SP7: - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - -
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - - - - - -
SP13: - -
SP14: - - - - - - - - -
SP15: - - - - -
SP16:
SP17: - - -
SP18: - - - - - - - - - - -
SP19:

ExUns: 13b · 13c ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16: - - - - -
SP17:
SP18:
SP19:

Relevant External Links for ZFAND4 Gene

GeneLoc Exon Structure for
ZFAND4
ECgene alternative splicing isoforms for
ZFAND4

Expression for ZFAND4 Gene

mRNA expression in normal human tissues for ZFAND4 Gene

mRNA differential expression in normal tissues according to GTEx for ZFAND4 Gene

This gene is overexpressed in Testis (10.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZFAND4 Gene

SOURCE GeneReport for Unigene cluster for ZFAND4 Gene Hs.89029

genes like me logo Genes that share expressions with ZFAND4: view

Orthologs for ZFAND4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFAND4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANUBL1 36
  • 99.27 (n)
  • 98.49 (a)
ZFAND4 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANUBL1 37
  • 74 (a)
OneToOne
ZFAND4 36
  • 84.98 (n)
  • 76.55 (a)
dog
(Canis familiaris)
Mammalia ZFAND4 36
  • 87.45 (n)
  • 78.76 (a)
ZFAND4 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfand4 36
  • 80.83 (n)
  • 74.07 (a)
Zfand4 16
Zfand4 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFAND4 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 50 (a)
OneToMany
-- 37
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfand4 36
  • 81.25 (n)
  • 73.76 (a)
chicken
(Gallus gallus)
Aves ZFAND4 36
  • 70 (n)
  • 62.03 (a)
ZFAND4 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFAND4 37
  • 16 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397781 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100144290 36
  • 73.67 (n)
  • 71.69 (a)
Str.20232 36
zebrafish
(Danio rerio)
Actinopterygii Dr.15582 36
zfand4 36
  • 56.45 (n)
  • 53.47 (a)
zfand4 37
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RpL40 37
  • 40 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL40A 37
  • 36 (a)
ManyToMany
RPL40B 37
  • 36 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.488 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 22 (a)
OneToMany
-- 37
  • 53 (a)
OneToMany
Species with no ortholog for ZFAND4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFAND4 Gene

ENSEMBL:
Gene Tree for ZFAND4 (if available)
TreeFam:
Gene Tree for ZFAND4 (if available)

Paralogs for ZFAND4 Gene

Paralogs for ZFAND4 Gene

Selected SIMAP similar genes for ZFAND4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZFAND4: view

Variants for ZFAND4 Gene

Sequence variations from dbSNP and Humsavar for ZFAND4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1060848 -- 45,616,502(-) AAGAG(C/T)GCAGG synonymous-codon, reference
rs1072929 -- 45,635,229(-) ttttt(G/T)tttgt intron-variant
rs1075000 -- 45,635,520(-) attta(G/T)atttg intron-variant
rs1201436 -- 45,625,211(+) ctcac(A/G)cctgt intron-variant
rs2305299 -- 45,641,545(+) GTGGG(C/T)TAATT intron-variant, upstream-variant-2KB

Relevant External Links for ZFAND4 Gene

HapMap Linkage Disequilibrium report
ZFAND4

No data available for Structural Variations from Database of Genomic Variants (DGV) for ZFAND4 Gene

Disorders for ZFAND4 Gene

No disorders were found for ZFAND4 Gene.

No data available for UniProtKB/Swiss-Prot for ZFAND4 Gene

Publications for ZFAND4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3

Products for ZFAND4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZFAND4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZFAND4
    • Block miRNA regulation of ZFAND4 using miScript Target Protectors

    Sources for ZFAND4 Gene

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