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Aliases for ZFAND4 Gene

Aliases for ZFAND4 Gene

  • Zinc Finger AN1-Type Containing 4 2 3
  • Zinc Finger, AN1-Type Domain 4 2 3 5
  • AN1-Type Zinc Finger And Ubiquitin Domain-Containing Protein-Like 1 3 4
  • ANUBL1 3 4
  • AN1-Type Zinc Finger And Ubiquitin Domain-Containing Protein 1 3
  • AN1, Ubiquitin-Like, Homolog (Xenopus Laevis) 2
  • AN1, Ubiquitin-Like, Homolog 3

External Ids for ZFAND4 Gene

Previous HGNC Symbols for ZFAND4 Gene

  • ANUBL1

Previous GeneCards Identifiers for ZFAND4 Gene

  • GC10M046112

Summaries for ZFAND4 Gene

GeneCards Summary for ZFAND4 Gene

ZFAND4 (Zinc Finger AN1-Type Containing 4) is a Protein Coding gene. An important paralog of this gene is ZFAND5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND4 Gene

Genomics for ZFAND4 Gene

Regulatory Elements for ZFAND4 Gene

Promoters for ZFAND4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZFAND4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZFAND4 Gene

Chromosome:
10
Start:
45,614,567 bp from pter
End:
45,672,962 bp from pter
Size:
58,396 bases
Orientation:
Minus strand

Genomic View for ZFAND4 Gene

Genes around ZFAND4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND4 Gene

Proteins for ZFAND4 Gene

  • Protein details for ZFAND4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XD8-ZFAN4_HUMAN
    Recommended name:
    AN1-type zinc finger protein 4
    Protein Accession:
    Q86XD8
    Secondary Accessions:
    • A8K8V4
    • B2RAX2
    • Q5VVY5

    Protein attributes for ZFAND4 Gene

    Size:
    727 amino acids
    Molecular mass:
    80358 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZFAND4 Gene

Proteomics data for ZFAND4 Gene at MOPED

Post-translational modifications for ZFAND4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFAND4 Gene

Antibody Products

No data available for DME Specific Peptides for ZFAND4 Gene

Domains & Families for ZFAND4 Gene

Gene Families for ZFAND4 Gene

Protein Domains for ZFAND4 Gene

Graphical View of Domain Structure for InterPro Entry

Q86XD8

UniProtKB/Swiss-Prot:

ZFAN4_HUMAN :
  • Contains 1 ubiquitin-like domain.
  • Contains 1 AN1-type zinc finger.
Domain:
  • Contains 1 ubiquitin-like domain.
Similarity:
  • Contains 1 AN1-type zinc finger.
genes like me logo Genes that share domains with ZFAND4: view

Function for ZFAND4 Gene

genes like me logo Genes that share phenotypes with ZFAND4: view

Animal Model Products

miRNA for ZFAND4 Gene

miRTarBase miRNAs that target ZFAND4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND4 Gene

Localization for ZFAND4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFAND4 Gene COMPARTMENTS Subcellular localization image for ZFAND4 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZFAND4 Gene

Pathways & Interactions for ZFAND4 Gene

SuperPathways for ZFAND4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZFAND4 Gene

Drugs & Compounds for ZFAND4 Gene

No Compound Related Data Available

Transcripts for ZFAND4 Gene

Unigene Clusters for ZFAND4 Gene

Zinc finger, AN1-type domain 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a ·
SP1: - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - -
SP6:
SP7: - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - -
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - - - - - -
SP13: - -
SP14: - - - - - - - - -
SP15: - - - - -
SP16:
SP17: - - -
SP18: - - - - - - - - - - -
SP19:

ExUns: 13b · 13c ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - -
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16: - - - - -
SP17:
SP18:
SP19:

Relevant External Links for ZFAND4 Gene

GeneLoc Exon Structure for
ZFAND4
ECgene alternative splicing isoforms for
ZFAND4

Expression for ZFAND4 Gene

mRNA expression in normal human tissues for ZFAND4 Gene

mRNA differential expression in normal tissues according to GTEx for ZFAND4 Gene

This gene is overexpressed in Testis (x10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZFAND4 Gene



SOURCE GeneReport for Unigene cluster for ZFAND4 Gene Hs.89029

genes like me logo Genes that share expression patterns with ZFAND4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZFAND4 Gene

Orthologs for ZFAND4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZFAND4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANUBL1 35
  • 99.27 (n)
  • 98.49 (a)
ZFAND4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANUBL1 36
  • 74 (a)
OneToOne
ZFAND4 35
  • 84.98 (n)
  • 76.55 (a)
dog
(Canis familiaris)
Mammalia ZFAND4 35
  • 87.45 (n)
  • 78.76 (a)
ZFAND4 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfand4 16
Zfand4 35
  • 80.83 (n)
  • 74.07 (a)
Zfand4 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFAND4 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Zfand4 35
  • 81.25 (n)
  • 73.76 (a)
chicken
(Gallus gallus)
Aves ZFAND4 36
  • 61 (a)
OneToOne
ZFAND4 35
  • 70 (n)
  • 62.03 (a)
lizard
(Anolis carolinensis)
Reptilia ZFAND4 36
  • 16 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397781 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100144290 35
  • 73.67 (n)
  • 71.69 (a)
Str.20232 35
zebrafish
(Danio rerio)
Actinopterygii zfand4 36
  • 47 (a)
OneToOne
Dr.15582 35
zfand4 35
  • 56.45 (n)
  • 53.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL40 36
  • 40 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL40A 36
  • 36 (a)
ManyToMany
RPL40B 36
  • 36 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.488 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
Species with no ortholog for ZFAND4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFAND4 Gene

ENSEMBL:
Gene Tree for ZFAND4 (if available)
TreeFam:
Gene Tree for ZFAND4 (if available)

Paralogs for ZFAND4 Gene

Paralogs for ZFAND4 Gene

(8) SIMAP similar genes for ZFAND4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZFAND4: view

Variants for ZFAND4 Gene

Sequence variations from dbSNP and Humsavar for ZFAND4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1060848 -- 45,616,502(-) AAGAG(C/T)GCAGG reference, synonymous-codon
rs1072929 -- 45,635,229(-) ttttt(G/T)tttgt intron-variant
rs1075000 -- 45,635,520(-) attta(G/T)atttg intron-variant
rs2305299 -- 45,641,545(+) GTGGG(C/T)TAATT intron-variant
rs3802543 -- 45,673,644(-) TAGAC(C/T)GGCTC upstream-variant-2KB

Variation tolerance for ZFAND4 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.53; 82.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFAND4 Gene

HapMap Linkage Disequilibrium report
ZFAND4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZFAND4 Gene

Disorders for ZFAND4 Gene

Relevant External Links for ZFAND4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFAND4

No disorders were found for ZFAND4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND4 Gene

Publications for ZFAND4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZFAND4 Gene

Sources for ZFAND4 Gene

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