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ZFAND3 Gene

protein-coding   GIFtS: 51
GCID: GC06P037787

Zinc Finger, AN1-Type Domain 3

(Previous name: testis expressed sequence 27)
(Previous symbol: TEX27)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, AN1-Type Domain 31 2
TEX271 2 3 5
Testis Expressed Sequence 271 2
AN1-Type Zinc Finger Protein 32
Testis-Expressed Sequence 273

External Ids:    HGNC: 180191   Entrez Gene: 606852   Ensembl: ENSG000001566397   OMIM: 6074555   UniProtKB: Q9H8U33   

Export aliases for ZFAND3 gene to outside databases

Previous GC identifers: GC06P037896 GC06P037507


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZFAND3 Gene:
ZFAND3 (zinc finger, AN1-type domain 3) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFAND3 gene promoter:
         GR   c-Fos   AP-1   HOXA3   GR-beta   NF-kappaB   LCR-F1   HNF-4alpha1   c-Jun   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZFAND3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFAND3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.2

ZFAND3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFAND3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P037787:  view genomic region     (about GC identifiers)

Start:
37,787,275 bp from pter      End:
38,122,400 bp from pter
Size:
335,126 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZFAN3_HUMAN, Q9H8U3 (See protein sequence)
Recommended Name: AN1-type zinc finger protein 3  
Size: 227 amino acids; 25184 Da
1 PDB 3D structure from and Proteopedia for ZFAND3:
1X4W (3D)    
Secondary accessions: Q5SZZ0 Q5SZZ1

Explore the universe of human proteins at neXtProt for ZFAND3: NX_Q9H8U3

Explore proteomics data for ZFAND3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZFAND3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_068762.1  
    ENSEMBL proteins: 
     ENSP00000287218   ENSP00000362489   ENSP00000420240   ENSP00000362487  

    ZFAND3 Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for ZFAND3
    Cloud-Clone Corp. Proteins for ZFAND3

     
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    antibodies-online proteins for ZFAND3 (8 products) 

     
    antibodies-online peptides for ZFAND3

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    antibodies-online antibodies for ZFAND3 (10 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFAND: Zinc fingers, AN1-type domain containing

    2 InterPro protein domains:
     IPR000058 Znf_AN1
     IPR002653 Znf_A20

    Graphical View of Domain Structure for InterPro Entry Q9H8U3

    ProtoNet protein and cluster: Q9H8U3

    2 Blocks protein domains:
    IPB000058 Zn-finger
    IPB002653 Zn-finger


    UniProtKB/Swiss-Prot: ZFAN3_HUMAN, Q9H8U3
    Similarity: Contains 1 A20-type zinc finger
    Similarity: Contains 1 AN1-type zinc finger


    Find genes that share domains with ZFAND3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ZFAND3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZFAND3:
     Decreased viability with pacli  Increased HPV18 LCR reporter a 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZFAND3

    miRNA
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    miRTarBase miRNAs that target ZFAND3:
    hsa-mir-98-5p (MIRT027403), hsa-mir-335-5p (MIRT016738)

    Block miRNA regulation of human, mouse, rat ZFAND3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZFAND3 (see all 73):
    hsa-miR-100* hsa-miR-300 hsa-miR-605 hsa-miR-149 hsa-miR-508-5p hsa-miR-3613-3p hsa-miR-761 hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidZFAND3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZFAND3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    extracellular2
    cytosol1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFAND3
    Interactions:

        Search GeneGlobe Interaction Network for ZFAND3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for ZFAND3 (Q9H8U32, 3 ENSP000002872184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLM1Q8NBJ42, 3, ENSP000003733634MINT-64971 I2D: score=4 STRING: ENSP00000373363
    UBCP0CG483I2D: score=1 
    IKBKGENSP000003586224STRING: ENSP00000358622
    TNFAIP3ENSP000002372894STRING: ENSP00000237289
    TRAF3ENSP000003324684STRING: ENSP00000332468
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFAND3 (ZFAN3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZFAND3 gene: 
    NM_021943.2  

    Unigene Cluster for ZFAND3:

    Zinc finger, AN1-type domain 3
    Hs.36959  [show with all ESTs]
    Unigene Representative Sequence: NM_021943
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287218(uc003onx.3) ENST00000373391 ENST00000474522 ENST00000373389
    ENST00000469208 ENST00000440482 ENST00000463847
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZFAND3 (see all 73):
    hsa-miR-100* hsa-miR-300 hsa-miR-605 hsa-miR-149 hsa-miR-508-5p hsa-miR-3613-3p hsa-miR-761 hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidZFAND3 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZFAND3
      QuantiTect SYBR Green Assays in human, mouse, rat ZFAND3
      QuantiFast Probe-based Assays in human, mouse, rat ZFAND3

    Additional mRNA sequence: 

    AK023284.1 AK310757.1 AL137302.1 BC031481.2 

    13 DOTS entries:

    DT.95192871  DT.448167  DT.100793832  DT.86841488  DT.100793831  DT.91691331  DT.100793835  DT.121380405 
    DT.121380479  DT.92414487  DT.92434806  DT.95192884  DT.455566 

    Selected AceView cDNA sequences (see all 328):

    BM977605 BM142117 AW468237 AI873740 AA252573 CA442816 BC031481 AI627694 
    BM142164 BQ109387 AI568926 BQ014509 AI085663 Z42477 AI799275 AI688175 
    CK819934 AI660240 CA394481 CK819935 BM673541 BE302409 BF724993 H92796 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND3 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e
    SP1:        -                 -     -                 -           -     -                                 
    SP2:        -                                                                                             
    SP3:                          -     -                 -     -     -     -                                 
    SP4:                                                  -                                                   
    SP5:                                            -     -           -     -                                 


    ECgene alternative splicing isoforms for ZFAND3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFAND3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCGCTTCCT
    ZFAND3 Expression
    About this image


    ZFAND3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Uterus (Reproductive System)
    ZFAND3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFAND3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.36959
        Custom PCR Arrays for ZFAND3
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZFAND3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfand31 , 5 zinc finger, AN1-type domain 31, 5 91.71(n)1
    95.12(a)1
      17 (15.59 cM)5
    217691  NM_148926.21  NP_683728.11 
     300050875 
    chicken
    (Gallus gallus)
    Aves ZFAND31 zinc finger, AN1-type domain 3 82.85(n)
    87.38(a)
      421430  XM_419483.4  XP_419483.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZFAND36
    Uncharacterized protein; Zinc finger AN1-type doma...
    82(a)
    1 ↔ 1
    1(229525604-229707508)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.242002 Xenopus laevis transcribed sequence with moderate similarity more 81.62(n)    CF548372.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj17a092 Transcribed sequence with weak similarity to protein more 78.31(n)    57092872 


    ENSEMBL Gene Tree for ZFAND3 (if available)
    TreeFam Gene Tree for ZFAND3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFAND3 (see all 6766)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs563494611,2
    C--37751010(+) TTTTT-/T/TTT 
            
    AATAT
    1 -- int11NA 2
    rs105252521,2
    C--37777822(+) ttttt-/T/TTT/TT
    TTT
    /TTTTTT
    GGTGG
    2 -- int1 cds11NA 2
    rs1472362131,2
    --37785350(+) AACTCA/CAAGGC 1 -- us2k10--------
    rs1835143801,2
    --37785364(+) TAAGTA/GTCTCA 1 -- us2k10--------
    rs1439462671,2
    --37785467(+) ATGCA-/TTTTTT 1 -- us2k10--------
    rs1819781,2
    C,F,A--37785474(+) TTTTTT/CTTTCT 1 -- us2k1 trp38Minor allele frequency- C:0.39NA WA EA 368
    rs1407351191,2
    --37785485(+) TTCTTC/TCTTTT 1 -- us2k10--------
    rs69081061,2
    C,F,A,H--37785490(+) tctttT/Atttga 1 -- us2k1 trp39Minor allele frequency- A:0.23NS EA NA WA CSA 661
    rs1880958681,2
    --37785510(+) TCGCTC/TTCGCT 1 -- us2k10--------
    rs1497787331,2
    --37785549(+) ATGATC/TTCGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZFAND3 (37787275 - 38037275 bp, first 250kb of ZFAND3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZFAND3 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731942CNV Deletion23290073
    esv2731939CNV Deletion23290073
    esv2731944CNV Deletion23290073
    esv2668461CNV Deletion23128226
    esv2731945CNV Deletion23290073
    esv2731943CNV Deletion23290073
    esv989910CNV Deletion20482838
    esv2731946CNV Deletion23290073
    esv990874CNV Deletion20482838
    esv2731938CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ZFAND3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607455    OMIM disorders: --


    Find genes that share disorders with ZFAND3           About GenesLikeMe

    Genetic Association Database (GAD): ZFAND3
    Human Genome Epidemiology (HuGE) Navigator: ZFAND3 (1 document)

    Export disorders for ZFAND3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ZFAND3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ZFAND3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PubMed id 22158537)1, 4 Cho Y.S....Seielstad M. (Nat. Genet. 2012)
    2. Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study. (PubMed id 21901158)1, 4 Irvin M.R....Arnett D.K. (PLoS ONE 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Identification of polyubiquitin binding proteins involved in NF- kappaB signaling using protein arrays. (PubMed id 19285159)1 Fenner B.J.... Prehn J.H. (Biochim. Biophys. Acta 2009)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    10. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 60685 HGNC: 18019 AceView: TEX27 Ensembl:ENSG00000156639 euGenes: HUgn60685
    ECgene: ZFAND3 H-InvDB: ZFAND3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZFAND3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFAND3 gene:
    Search GeneIP for patents involving ZFAND3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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