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Aliases for ZFAND3 Gene

Aliases for ZFAND3 Gene

  • Zinc Finger AN1-Type Containing 3 2 3
  • Zinc Finger, AN1-Type Domain 3 2 3 5
  • Testis Expressed Sequence 27 2 3
  • TEX27 3 4
  • Testis-Expressed Sequence 27 4

External Ids for ZFAND3 Gene

Previous HGNC Symbols for ZFAND3 Gene

  • TEX27

Previous GeneCards Identifiers for ZFAND3 Gene

  • GC06P037896
  • GC06P037787
  • GC06P037507
  • GC06P037940

Summaries for ZFAND3 Gene

GeneCards Summary for ZFAND3 Gene

ZFAND3 (Zinc Finger AN1-Type Containing 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND3 Gene

Genomics for ZFAND3 Gene

Regulatory Elements for ZFAND3 Gene

Promoters for ZFAND3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZFAND3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZFAND3 Gene

Chromosome:
6
Start:
37,819,496 bp from pter
End:
38,154,624 bp from pter
Size:
335,129 bases
Orientation:
Plus strand

Genomic View for ZFAND3 Gene

Genes around ZFAND3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND3 Gene

Proteins for ZFAND3 Gene

  • Protein details for ZFAND3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8U3-ZFAN3_HUMAN
    Recommended name:
    AN1-type zinc finger protein 3
    Protein Accession:
    Q9H8U3
    Secondary Accessions:
    • Q5SZZ0
    • Q5SZZ1

    Protein attributes for ZFAND3 Gene

    Size:
    227 amino acids
    Molecular mass:
    25184 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZFAND3 Gene

neXtProt entry for ZFAND3 Gene

Proteomics data for ZFAND3 Gene at MOPED

Post-translational modifications for ZFAND3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFAND3 Gene

No data available for DME Specific Peptides for ZFAND3 Gene

Domains & Families for ZFAND3 Gene

Gene Families for ZFAND3 Gene

Protein Domains for ZFAND3 Gene

Suggested Antigen Peptide Sequences for ZFAND3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H8U3

UniProtKB/Swiss-Prot:

ZFAN3_HUMAN :
  • Contains 1 A20-type zinc finger.
Similarity:
  • Contains 1 A20-type zinc finger.
  • Contains 1 AN1-type zinc finger.
genes like me logo Genes that share domains with ZFAND3: view

Function for ZFAND3 Gene

Gene Ontology (GO) - Molecular Function for ZFAND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZFAND3: view
genes like me logo Genes that share phenotypes with ZFAND3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND3 Gene

Localization for ZFAND3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFAND3 Gene COMPARTMENTS Subcellular localization image for ZFAND3 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZFAND3 Gene

Pathways & Interactions for ZFAND3 Gene

SuperPathways for ZFAND3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZFAND3 Gene

Drugs & Compounds for ZFAND3 Gene

No Compound Related Data Available

Transcripts for ZFAND3 Gene

Unigene Clusters for ZFAND3 Gene

Zinc finger, AN1-type domain 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - - - -
SP2: -
SP3: - - - - - -
SP4: -
SP5: - - - -
SP6: - -
SP7: - -
SP8:

Relevant External Links for ZFAND3 Gene

GeneLoc Exon Structure for
ZFAND3
ECgene alternative splicing isoforms for
ZFAND3

Expression for ZFAND3 Gene

mRNA expression in normal human tissues for ZFAND3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFAND3 Gene

This gene is overexpressed in Fetal ovary (51.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFAND3 Gene



SOURCE GeneReport for Unigene cluster for ZFAND3 Gene Hs.36959

genes like me logo Genes that share expression patterns with ZFAND3: view

Protein tissue co-expression partners for ZFAND3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFAND3 Gene

Orthologs for ZFAND3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFAND3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZFAND3 35
  • 94.57 (n)
  • 97.8 (a)
ZFAND3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFAND3 35
  • 95.45 (n)
  • 98.68 (a)
ZFAND3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfand3 35
  • 91.71 (n)
  • 95.12 (a)
Zfand3 16
Zfand3 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZFAND3 35
  • 99.84 (n)
  • 100 (a)
ZFAND3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfand3 35
  • 91.48 (n)
  • 95.15 (a)
oppossum
(Monodelphis domestica)
Mammalia ZFAND3 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFAND3 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFAND3 35
  • 82.85 (n)
  • 87.38 (a)
ZFAND3 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFAND3 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10054 35
zfand3 35
  • 80.59 (n)
  • 86.22 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24200 35
zebrafish
(Danio rerio)
Actinopterygii wufj17a09 35
zfand3 35
  • 67.74 (n)
  • 70.64 (a)
zfand3 36
  • 66 (a)
OneToOne
Species with no ortholog for ZFAND3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFAND3 Gene

ENSEMBL:
Gene Tree for ZFAND3 (if available)
TreeFam:
Gene Tree for ZFAND3 (if available)

Paralogs for ZFAND3 Gene

No data available for Paralogs for ZFAND3 Gene

Variants for ZFAND3 Gene

Sequence variations from dbSNP and Humsavar for ZFAND3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs171831 -- 37,908,610(+) tggag(G/T)ttcct intron-variant
rs174105 -- 37,898,133(+) AGACA(C/T)TCGAG intron-variant
rs174106 -- 37,902,394(+) cccaa(A/G)aggtt intron-variant
rs13552 -- 38,153,184(+) TGGCA(C/T)GGACC utr-variant-3-prime
rs181978 -- 37,817,698(+) TTTTT(C/T)TTTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZFAND3 Gene

Variant ID Type Subtype PubMed ID
esv2731938 CNV Deletion 23290073
esv990874 CNV Deletion 20482838
nsv348662 CNV Loss 16902084
esv991004 CNV Loss 20482838
nsv823674 CNV Loss 20364138
esv2731939 CNV Deletion 23290073
esv2668461 CNV Deletion 23128226
esv23277 CNV Loss 19812545
esv260066 OTHER Complex 20981092
esv34450 CNV Gain 17911159
esv2731941 CNV Deletion 23290073
esv2731942 CNV Deletion 23290073
esv2731943 CNV Deletion 23290073
nsv885817 CNV Loss 21882294
nsv507324 CNV Insertion 20534489
esv2731944 CNV Deletion 23290073
esv2731945 CNV Deletion 23290073
esv989910 CNV Deletion 20482838
esv1320553 CNV Deletion 17803354
nsv524213 CNV Loss 19592680
esv2731946 CNV Deletion 23290073

Variation tolerance for ZFAND3 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFAND3 Gene

HapMap Linkage Disequilibrium report
ZFAND3
Human Gene Mutation Database (HGMD)
ZFAND3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND3 Gene

Disorders for ZFAND3 Gene

Relevant External Links for ZFAND3

Genetic Association Database (GAD)
ZFAND3
Human Genome Epidemiology (HuGE) Navigator
ZFAND3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFAND3

No disorders were found for ZFAND3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND3 Gene

Publications for ZFAND3 Gene

  1. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho Y.S. … Seielstad M. (Nat. Genet. 2012) 3 48 67
  2. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  3. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N. … Gallagher E. (EMBO J. 2014) 3
  4. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3
  5. Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study. (PMID: 21901158) Irvin M.R. … Arnett D.K. (PLoS ONE 2011) 3

Products for ZFAND3 Gene

Sources for ZFAND3 Gene

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