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Aliases for ZFAND3 Gene

Aliases for ZFAND3 Gene

  • Zinc Finger AN1-Type Containing 3 2 3 5
  • Zinc Finger, AN1-Type Domain 3 2 3
  • Testis Expressed Sequence 27 2 3
  • TEX27 3 4
  • AN1-Type Zinc Finger Protein 3 3
  • Testis-Expressed Sequence 27 4

External Ids for ZFAND3 Gene

Previous HGNC Symbols for ZFAND3 Gene

  • TEX27

Previous GeneCards Identifiers for ZFAND3 Gene

  • GC06P037896
  • GC06P037787
  • GC06P037507
  • GC06P037940
  • GC06P037950

Summaries for ZFAND3 Gene

GeneCards Summary for ZFAND3 Gene

ZFAND3 (Zinc Finger AN1-Type Containing 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND3 Gene

Genomics for ZFAND3 Gene

Regulatory Elements for ZFAND3 Gene

Enhancers for ZFAND3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZFAND3 on UCSC Golden Path with GeneCards custom track

Promoters for ZFAND3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZFAND3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZFAND3 Gene

Chromosome:
6
Start:
37,819,496 bp from pter
End:
38,154,624 bp from pter
Size:
335,129 bases
Orientation:
Plus strand

Genomic View for ZFAND3 Gene

Genes around ZFAND3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND3 Gene

Proteins for ZFAND3 Gene

  • Protein details for ZFAND3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8U3-ZFAN3_HUMAN
    Recommended name:
    AN1-type zinc finger protein 3
    Protein Accession:
    Q9H8U3
    Secondary Accessions:
    • Q5SZZ0
    • Q5SZZ1

    Protein attributes for ZFAND3 Gene

    Size:
    227 amino acids
    Molecular mass:
    25184 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZFAND3 Gene

neXtProt entry for ZFAND3 Gene

Post-translational modifications for ZFAND3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFAND3 Gene

No data available for DME Specific Peptides for ZFAND3 Gene

Domains & Families for ZFAND3 Gene

Gene Families for ZFAND3 Gene

Protein Domains for ZFAND3 Gene

Suggested Antigen Peptide Sequences for ZFAND3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H8U3

UniProtKB/Swiss-Prot:

ZFAN3_HUMAN :
  • Contains 1 A20-type zinc finger.
Similarity:
  • Contains 1 A20-type zinc finger.
  • Contains 1 AN1-type zinc finger.
genes like me logo Genes that share domains with ZFAND3: view

Function for ZFAND3 Gene

Gene Ontology (GO) - Molecular Function for ZFAND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZFAND3: view
genes like me logo Genes that share phenotypes with ZFAND3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND3 Gene

Localization for ZFAND3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFAND3 Gene COMPARTMENTS Subcellular localization image for ZFAND3 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZFAND3 Gene

Pathways & Interactions for ZFAND3 Gene

SuperPathways for ZFAND3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZFAND3 Gene

Drugs & Compounds for ZFAND3 Gene

No Compound Related Data Available

Transcripts for ZFAND3 Gene

Unigene Clusters for ZFAND3 Gene

Zinc finger, AN1-type domain 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - - - -
SP2: -
SP3: - - - - - -
SP4: -
SP5: - - - -
SP6: - -
SP7: - -
SP8:

Relevant External Links for ZFAND3 Gene

GeneLoc Exon Structure for
ZFAND3
ECgene alternative splicing isoforms for
ZFAND3

Expression for ZFAND3 Gene

mRNA expression in normal human tissues for ZFAND3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFAND3 Gene

This gene is overexpressed in Fetal ovary (51.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFAND3 Gene



Protein tissue co-expression partners for ZFAND3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFAND3 Gene:

ZFAND3

SOURCE GeneReport for Unigene cluster for ZFAND3 Gene:

Hs.36959
genes like me logo Genes that share expression patterns with ZFAND3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFAND3 Gene

Orthologs for ZFAND3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFAND3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZFAND3 34
  • 94.57 (n)
  • 97.8 (a)
ZFAND3 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFAND3 34
  • 95.45 (n)
  • 98.68 (a)
ZFAND3 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfand3 34
  • 91.71 (n)
  • 95.12 (a)
Zfand3 16
Zfand3 35
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZFAND3 34
  • 99.84 (n)
  • 100 (a)
ZFAND3 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfand3 34
  • 91.48 (n)
  • 95.15 (a)
oppossum
(Monodelphis domestica)
Mammalia ZFAND3 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFAND3 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFAND3 34
  • 82.85 (n)
  • 87.38 (a)
ZFAND3 35
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFAND3 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10054 34
zfand3 34
  • 80.59 (n)
  • 86.22 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24200 34
zebrafish
(Danio rerio)
Actinopterygii wufj17a09 34
zfand3 34
  • 67.74 (n)
  • 70.64 (a)
zfand3 35
  • 66 (a)
OneToOne
Species where no ortholog for ZFAND3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFAND3 Gene

ENSEMBL:
Gene Tree for ZFAND3 (if available)
TreeFam:
Gene Tree for ZFAND3 (if available)

Paralogs for ZFAND3 Gene

No data available for Paralogs for ZFAND3 Gene

Variants for ZFAND3 Gene

Sequence variations from dbSNP and Humsavar for ZFAND3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs876818 -- 38,152,884(-) CTCCC(A/G)TGGCC utr-variant-3-prime
rs881681 -- 38,152,119(+) AGTGA(C/G)TGTTG intron-variant, utr-variant-3-prime
rs903930 -- 37,985,527(-) ggggg(G/T)gtgtg intron-variant
rs941850 -- 38,143,173(-) TCGGC(G/T)TCGTC intron-variant
rs966705 -- 37,939,823(-) acctc(A/G)tgatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFAND3 Gene

Variant ID Type Subtype PubMed ID
esv1320553 CNV deletion 17803354
esv23277 CNV loss 19812545
esv2668461 CNV deletion 23128226
esv2731938 CNV deletion 23290073
esv2731939 CNV deletion 23290073
esv2731941 CNV deletion 23290073
esv2731942 CNV deletion 23290073
esv2731943 CNV deletion 23290073
esv2731944 CNV deletion 23290073
esv2731945 CNV deletion 23290073
esv2731946 CNV deletion 23290073
esv2761037 CNV loss 21179565
esv2763549 CNV loss 21179565
esv3083578 CNV deletion 24192839
esv3286606 CNV deletion 24192839
esv3303092 CNV tandem duplication 20981092
esv34450 CNV gain 17911159
esv3567660 CNV deletion 23714750
esv3571019 CNV loss 25503493
esv3571021 CNV loss 25503493
esv3576142 CNV gain 25503493
esv3608721 CNV gain 21293372
esv3608722 CNV gain 21293372
esv3608723 CNV gain 21293372
esv3608724 CNV loss 21293372
esv3608726 CNV gain 21293372
esv3608727 CNV loss 21293372
esv989910 CNV deletion 20482838
esv990874 CNV deletion 20482838
esv991004 CNV loss 20482838
nsv1015689 CNV gain 25217958
nsv1020625 CNV gain 25217958
nsv1073550 CNV deletion 25765185
nsv1114798 CNV deletion 24896259
nsv1145099 CNV deletion 24896259
nsv348662 CNV deletion 16902084
nsv478390 CNV novel sequence insertion 20440878
nsv507324 OTHER sequence alteration 20534489
nsv524213 CNV loss 19592680
nsv602956 CNV loss 21841781
nsv823674 CNV loss 20364138
nsv950164 CNV duplication 24416366
nsv950165 CNV duplication 24416366
nsv950166 CNV deletion 24416366

Variation tolerance for ZFAND3 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFAND3 Gene

Human Gene Mutation Database (HGMD)
ZFAND3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFAND3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND3 Gene

Disorders for ZFAND3 Gene

Relevant External Links for ZFAND3

Genetic Association Database (GAD)
ZFAND3
Human Genome Epidemiology (HuGE) Navigator
ZFAND3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFAND3

No disorders were found for ZFAND3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND3 Gene

Publications for ZFAND3 Gene

  1. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho Y.S. … Seielstad M. (Nat. Genet. 2012) 3 46 65
  2. Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study. (PMID: 21901158) Irvin M.R. … Arnett D.K. (PLoS ONE 2011) 3 46 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for ZFAND3 Gene

Sources for ZFAND3 Gene

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