ZFAND3 Gene
protein-coding GIFtS: 48
GCID: GC06P037787
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|
zinc finger, AN1-type domain 3(Previous name: testis expressed sequence 27 )
(Previous symbol: TEX27)
| |
Aliases
for ZFAND3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, AN1-Type Domain 31 2 | | TEX271 2 3 5 | | Testis Expressed Sequence 271 2 | | Testis-Expressed Sequence 272 3 | | FLJ132221 | | AN1-Type Zinc Finger Protein 32 |
Export aliases for ZFAND3 gene to outside databasesPrevious GC identifers: GC06P037896 GC06P037507 |
Summaries
for ZFAND3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZFAND3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZFAND3 gene promoter:
GR c-Fos AP-1 HOXA3 GR-beta NF-kappaB LCR-F1 HNF-4alpha1 c-Jun GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZFAND3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFAND3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6pter-p22.3 Ensembl cytogenetic band: 6p21.2 HGNC cytogenetic band: 6pter-p22.3ZFAND3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P037787: view genomic region
(about GC identifiers)
Start:
|
37,787,275 bp from pter |
End:
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38,122,400 bp from pter |
Size:
|
335,126 bases |
Orientation:
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plus strand |
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Proteins
for ZFAND3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZFAN3_HUMAN, Q9H8U3 (See
protein sequence)Recommended Name: AN1-type zinc finger protein 3 Size: 227 amino acids; 25184 Da
1 PDB 3D structure from  and Proteopedia  for ZFAND3:1X4W (3D)
Secondary accessions: Q5SZZ0 Q5SZZ1Explore the universe of human proteins at neXtProt for ZFAND3: NX_Q9H8U3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H8U3
ZFAND3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_068762.1
ENSEMBL proteins: ENSP00000287218 ENSP00000362489 ENSP00000420240 ENSP00000362487
Human Recombinant Protein Products:
ZFAND3 Antibody Products:
Assay Products for ZFAND3: |
Protein
Domains /
Families
for ZFAND3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZFAND3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H8U3ProtoNet protein and cluster: Q9H8U3 2 Blocks protein families: IPB000058 Zn-finger IPB002653 Zn-finger
UniProtKB/Swiss-Prot: ZFAN3_HUMAN, Q9H8U3Similarity: Contains 1 A20-type zinc fingerSimilarity: Contains 1 AN1-type zinc finger |
Function
for ZFAND3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZFAND3 (NM_021943) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZFAND3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFAND3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZFAND3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZFAND3:
|
Pathways & Interactions
for ZFAND3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFAND3
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for ZFAND3 (Q9H8U32, 3 ENSP000002872184) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ZFAND3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZFAND3
Search CenterWatch for drugs/clinical trials and news about ZFAND3 / ZFAN3
|
Transcripts
for ZFAND3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZFAND3 gene: NM_021943.2 Unigene Cluster for ZFAND3: Zinc finger, AN1-type domain 3 Hs.36959 [show with all ESTs]Unigene Representative Sequence: NM_0219437 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000287218(uc003onx.3) ENST00000373391 ENST00000474522 ENST00000373389
ENST00000469208 ENST00000440482 ENST00000463847
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZFAND3 (NM_021943) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZFAND3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFAND3 |
Additional cDNA sequence: AK023284.1 AK310757.1 AL137302.1 BC031481.2 13 DOTS entries: DT.95192871 DT.448167 DT.100793832 DT.86841488 DT.100793831 DT.91691331 DT.100793835 DT.121380405 DT.121380479 DT.92414487 DT.92434806 DT.95192884 DT.455566 24/328 AceView cDNA sequences (see all 328): H69506 BU684333 BQ008662 BP337229 BM833362 AI190680 BM922522 AW574820 BM055159 BM800663 BM918253 AL137302 BE673316 AI041300 AW054873 AA115156 AA886750 AI263955 AI142847 AI017706 BU902208 BU902089 BE906567 CB119626
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND3 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e |
|---|
|
| SP1: | | | - | | | | | | - | | - | | | | | | - | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZFAND3
|
Expression
for ZFAND3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZFAND3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCGCTTCCT
About this image
See ZFAND3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZFAND3
SOURCE GeneReport for Unigene cluster: Hs.36959
SABiosciences Custom PCR Arrays for ZFAND3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFAND3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZFAND3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFAND3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFAND3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND3 |
Orthologs
for ZFAND3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZFAND3 gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZFAND31 |
zinc finger, AN1-type domain 3 |
83.33(n)
88.38(a) |
|
421430 XM_419483.3 XP_419483.2 |
lizard
(Anolis carolinensis) |
Reptilia |
ZFAND36 |
-- |
52(a) |
1 ↔ 1 |
1(229679628-229679828) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.242002 |
Xenopus laevis transcribed sequence with moderate similarity more |
81.62(n) |
|
CF548372.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufj17a092 |
Transcribed sequence with weak similarity to protein more |
78.31(n) |
|
57092872 |
ENSEMBL Gene Tree for ZFAND3 (if available)
TreeFam Gene Tree for ZFAND3 (if available) |
Paralogs
for ZFAND3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZFAND3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZFAND3 (37787275 - 38037275 bp, first 250kb of ZFAND3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for ZFAND3
6 CNVs: 81377 8513 93684 93681 93686 64487
3 Indels: 93683 93685 93682 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFAND3 |
|
Disorders
/ Diseases
for ZFAND3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZFAND3 for disorders About GeneDecksing
OMIM gene information: 607455
OMIM disorders: --
1  disease for ZFAND3: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: ZFAND3 (1 document)
Export disorders for ZFAND3 gene to outside databases
|
Publications
for ZFAND3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZFAND3 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ZFAND3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Meta-analysis of genome-wide association studies ident ifies eight new loci for type 2 diabetes in east Asians. (PubMed id 22158537)1 Cho Y.S....Seielstad M. (2012)
- Genome-wide detection of allele specific copy number v ariation associated with insulin resistance in African Americans from the HyperG EN study. (PubMed id 21901158)1 Irvin M.R....Arnett D.K. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. (PubMed id 19285159)1 Fenner B.J....Prehn J.H. (2009)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZFAND3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZFAND3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZFAND3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZFAND3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZFAND3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZFAND3 gene:
Search GeneIP for patents involving ZFAND3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZFAND3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZFAND3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZFAND3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFAND3 | | | OriGene Protein Over-expression Lysate for ZFAND3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZFAND3 | | OriGene 3'-UTR Clone for ZFAND3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZFAND3 | | OriGene Custom Protein Services for ZFAND3 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZFAND3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFAND3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFAND3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZFAND3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFAND3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFAND3 |
| |
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| | | | Search Tocris compounds for ZFAND3 |
| |  |  |  |  | | | | |
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 | | | ZFAND3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND3 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZFAND3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFAND3 |
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