Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZFAND3 Gene

Aliases for ZFAND3 Gene

  • Zinc Finger AN1-Type Containing 3 2 3 5
  • Zinc Finger, AN1-Type Domain 3 2 3
  • Testis Expressed Sequence 27 2 3
  • Testis-Expressed Protein 27 3 4
  • TEX27 3 4
  • AN1-Type Zinc Finger Protein 3 3

External Ids for ZFAND3 Gene

Previous HGNC Symbols for ZFAND3 Gene

  • TEX27

Previous GeneCards Identifiers for ZFAND3 Gene

  • GC06P037896
  • GC06P037787
  • GC06P037507
  • GC06P037940
  • GC06P037950
  • GC06P038436
  • GC06P039027
  • GC06P039613

Summaries for ZFAND3 Gene

GeneCards Summary for ZFAND3 Gene

ZFAND3 (Zinc Finger AN1-Type Containing 3) is a Protein Coding gene.

Additional gene information for ZFAND3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND3 Gene

Genomics for ZFAND3 Gene

Regulatory Elements for ZFAND3 Gene

Enhancers for ZFAND3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H037782 1.3 FANTOM5 Ensembl ENCODE 12.7 -35.6 -35550 2 CTCF MAZ SP5 CEBPB ZIC2 RAD21 YY1 ZFHX2 POLR2A EED MDGA1 ENSG00000225945 ZFAND3 GC06P041745
GH06H037881 1 Ensembl ENCODE 11.6 +63.2 63188 1 SOX13 FOXA2 SAP130 CEBPG ZKSCAN1 TEAD3 ZNF121 ZFHX2 SMARCC2 FOS RNU1-87P ZFAND3 ENSG00000225945 MDGA1 BTBD9 GC06P041737 RN7SL285P
GH06H037987 1.1 Ensembl ENCODE 10.5 +170.2 170216 4 ELF3 SOX13 FOXA2 ZNF792 SAP130 ZFP64 ZNF140 RARA TEAD3 ZSCAN5C RNU1-87P CMTR1 ENSG00000225945 ZFAND3 MDGA1 BTBD9-AS1 CCDC167 ENSG00000218521
GH06H037866 0.8 Ensembl ENCODE 11.7 +48.8 48753 2 ZFHX2 ZNF366 JUN FOS PRDM10 PRDM1 EGR2 ZFAND3 ENSG00000225945 RNU1-87P BTBD9 GC06P041737 RN7SL285P
GH06H037777 0.8 FANTOM5 11.7 -42.0 -42036 0 HDGF PKNOX1 EBF1 ZIC2 RELA POLR2A EED PATZ1 ZSCAN29 RUNX3 ENSG00000225945 ZFAND3 GC06P041745
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFAND3 on UCSC Golden Path with GeneCards custom track

Promoters for ZFAND3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000196459 104 2801 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for ZFAND3 Gene

Chromosome:
6
Start:
37,819,496 bp from pter
End:
38,154,624 bp from pter
Size:
335,129 bases
Orientation:
Plus strand

Genomic View for ZFAND3 Gene

Genes around ZFAND3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND3 Gene

Proteins for ZFAND3 Gene

  • Protein details for ZFAND3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8U3-ZFAN3_HUMAN
    Recommended name:
    AN1-type zinc finger protein 3
    Protein Accession:
    Q9H8U3
    Secondary Accessions:
    • Q5SZZ0
    • Q5SZZ1

    Protein attributes for ZFAND3 Gene

    Size:
    227 amino acids
    Molecular mass:
    25184 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZFAND3 Gene

neXtProt entry for ZFAND3 Gene

Post-translational modifications for ZFAND3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFAND3 Gene

No data available for DME Specific Peptides for ZFAND3 Gene

Domains & Families for ZFAND3 Gene

Gene Families for ZFAND3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZFAND3 Gene

Suggested Antigen Peptide Sequences for ZFAND3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZFAND3: view

No data available for UniProtKB/Swiss-Prot for ZFAND3 Gene

Function for ZFAND3 Gene

Phenotypes From GWAS Catalog for ZFAND3 Gene

Gene Ontology (GO) - Molecular Function for ZFAND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFAND3: view
genes like me logo Genes that share phenotypes with ZFAND3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZFAND3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND3 Gene

Localization for ZFAND3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFAND3 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZFAND3 Gene

Pathways & Interactions for ZFAND3 Gene

SuperPathways for ZFAND3 Gene

No Data Available

Interacting Proteins for ZFAND3 Gene

Gene Ontology (GO) - Biological Process for ZFAND3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZFAND3 Gene

Drugs & Compounds for ZFAND3 Gene

No Compound Related Data Available

Transcripts for ZFAND3 Gene

Unigene Clusters for ZFAND3 Gene

Zinc finger, AN1-type domain 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZFAND3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - - - -
SP2: -
SP3: - - - - - -
SP4: -
SP5: - - - -
SP6: - -
SP7: - -
SP8:

Relevant External Links for ZFAND3 Gene

GeneLoc Exon Structure for
ZFAND3
ECgene alternative splicing isoforms for
ZFAND3

Expression for ZFAND3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFAND3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZFAND3 Gene

This gene is overexpressed in Fetal ovary (51.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFAND3 Gene



Protein tissue co-expression partners for ZFAND3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZFAND3 Gene:

ZFAND3

SOURCE GeneReport for Unigene cluster for ZFAND3 Gene:

Hs.36959

Evidence on tissue expression from TISSUES for ZFAND3 Gene

  • Kidney(4.4)
  • Nervous system(3.7)
  • Thyroid gland(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with ZFAND3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFAND3 Gene

Orthologs for ZFAND3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFAND3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFAND3 33 34
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia ZFAND3 33 34
  • 95.45 (n)
cow
(Bos Taurus)
Mammalia ZFAND3 33 34
  • 94.57 (n)
mouse
(Mus musculus)
Mammalia Zfand3 33 16 34
  • 91.71 (n)
rat
(Rattus norvegicus)
Mammalia Zfand3 33
  • 91.48 (n)
oppossum
(Monodelphis domestica)
Mammalia ZFAND3 34
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFAND3 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFAND3 33 34
  • 82.85 (n)
lizard
(Anolis carolinensis)
Reptilia ZFAND3 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfand3 33
  • 80.59 (n)
Str.10054 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24200 33
zebrafish
(Danio rerio)
Actinopterygii zfand3 33 34
  • 67.74 (n)
wufj17a09 33
Species where no ortholog for ZFAND3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFAND3 Gene

ENSEMBL:
Gene Tree for ZFAND3 (if available)
TreeFam:
Gene Tree for ZFAND3 (if available)

Paralogs for ZFAND3 Gene

No data available for Paralogs for ZFAND3 Gene

Variants for ZFAND3 Gene

Sequence variations from dbSNP and Humsavar for ZFAND3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000003471 -- 37,992,409(+) AGGTT(C/T)AAACC intron-variant
rs1000011192 -- 38,085,347(+) TACCT(C/T)CTCCC intron-variant
rs1000013551 -- 37,952,172(+) TTTGT(A/G)TGTGT intron-variant
rs1000060577 -- 37,828,219(+) TCCAG(C/G)CACTT intron-variant
rs1000062919 -- 37,999,954(+) CTATC(C/T)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFAND3 Gene

Variant ID Type Subtype PubMed ID
esv1320553 CNV deletion 17803354
esv23277 CNV loss 19812545
esv2668461 CNV deletion 23128226
esv2731938 CNV deletion 23290073
esv2731939 CNV deletion 23290073
esv2731941 CNV deletion 23290073
esv2731942 CNV deletion 23290073
esv2731943 CNV deletion 23290073
esv2731944 CNV deletion 23290073
esv2731945 CNV deletion 23290073
esv2731946 CNV deletion 23290073
esv2761037 CNV loss 21179565
esv2763549 CNV loss 21179565
esv3083578 CNV deletion 24192839
esv3286606 CNV deletion 24192839
esv3303092 CNV tandem duplication 20981092
esv34450 CNV gain 17911159
esv3567660 CNV deletion 23714750
esv3571019 CNV loss 25503493
esv3571021 CNV loss 25503493
esv3576142 CNV gain 25503493
esv3608721 CNV gain 21293372
esv3608722 CNV gain 21293372
esv3608723 CNV gain 21293372
esv3608724 CNV loss 21293372
esv3608726 CNV gain 21293372
esv3608727 CNV loss 21293372
esv989910 CNV deletion 20482838
esv990874 CNV deletion 20482838
esv991004 CNV loss 20482838
nsv1015689 CNV gain 25217958
nsv1020625 CNV gain 25217958
nsv1073550 CNV deletion 25765185
nsv1114798 CNV deletion 24896259
nsv1145099 CNV deletion 24896259
nsv348662 CNV deletion 16902084
nsv478390 CNV novel sequence insertion 20440878
nsv507324 OTHER sequence alteration 20534489
nsv524213 CNV loss 19592680
nsv602956 CNV loss 21841781
nsv823674 CNV loss 20364138
nsv950164 CNV duplication 24416366
nsv950165 CNV duplication 24416366
nsv950166 CNV deletion 24416366

Variation tolerance for ZFAND3 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFAND3 Gene

Human Gene Mutation Database (HGMD)
ZFAND3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZFAND3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND3 Gene

Disorders for ZFAND3 Gene

Relevant External Links for ZFAND3

Genetic Association Database (GAD)
ZFAND3
Human Genome Epidemiology (HuGE) Navigator
ZFAND3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFAND3

No disorders were found for ZFAND3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND3 Gene

Publications for ZFAND3 Gene

  1. Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study. (PMID: 21901158) Irvin MR … Arnett DK (PloS one 2011) 3 45 60
  2. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho YS … Seielstad M (Nature genetics 2011) 3 45 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for ZFAND3 Gene

Sources for ZFAND3 Gene

Content
Loading form....