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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFAND3 Gene

protein-coding   GIFtS: 48
GCID: GC06P037787

Zinc Finger, AN1-Type Domain 3

(Previous name: testis expressed sequence 27)
(Previous symbol: TEX27)
  Search for ZFAND3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, AN1-Type Domain 31 2
TEX271 2 3 5
Testis Expressed Sequence 271 2
Testis-Expressed Sequence 272 3
AN1-Type Zinc Finger Protein 32

External Ids:    HGNC: 180191   Entrez Gene: 606852   Ensembl: ENSG000001566397   OMIM: 6074555   UniProtKB: Q9H8U33   

Export aliases for ZFAND3 gene to outside databases

Previous GC identifers: GC06P037896 GC06P037507


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZFAND3 Gene: 
ZFAND3 (zinc finger, AN1-type domain 3) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFAND3 gene promoter:
         GR   c-Fos   AP-1   HOXA3   GR-beta   NF-kappaB   LCR-F1   HNF-4alpha1   c-Jun   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZFAND3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFAND3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.2

ZFAND3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFAND3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P037787:  view genomic region     (about GC identifiers)

Start:
37,787,275 bp from pter      End:
38,122,400 bp from pter
Size:
335,126 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZFAN3_HUMAN, Q9H8U3 (See protein sequence)
Recommended Name: AN1-type zinc finger protein 3  
Size: 227 amino acids; 25184 Da
1 PDB 3D structure from and Proteopedia for ZFAND3:
1X4W (3D)    
Secondary accessions: Q5SZZ0 Q5SZZ1

Explore the universe of human proteins at neXtProt for ZFAND3: NX_Q9H8U3

Explore proteomics data for ZFAND3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H8U3

  • ZFAND3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFAND3 Protein Expression
    REFSEQ proteins: NP_068762.1  
    ENSEMBL proteins: 
     ENSP00000287218   ENSP00000362489   ENSP00000420240   ENSP00000362487  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZFAND: Zinc fingers, AN1-type domain containing

    2 InterPro protein domains:
     IPR000058 Znf_AN1
     IPR002653 Znf_A20

    Graphical View of Domain Structure for InterPro Entry Q9H8U3

    ProtoNet protein and cluster: Q9H8U3

    2 Blocks protein domains:
    IPB000058 Zn-finger
    IPB002653 Zn-finger


    UniProtKB/Swiss-Prot: ZFAN3_HUMAN, Q9H8U3
    Similarity: Contains 1 A20-type zinc finger
    Similarity: Contains 1 AN1-type zinc finger


    ZFAND3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--
         
    ZFAND3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZFAND3:
     Decreased viability with pacli  Increased HPV18 LCR reporter a 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFAND3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for ZFAND3 (Q9H8U32, 3 ENSP000002872184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLM1Q8NBJ42, 3, ENSP000003733634MINT-64971 I2D: score=4 STRING: ENSP00000373363
    UBCP0CG483I2D: score=1 
    IKBKGENSP000003586224STRING: ENSP00000358622
    TNFAIP3ENSP000002372894STRING: ENSP00000237289
    TRAF3ENSP000003324684STRING: ENSP00000332468
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFAND3 (ZFAN3)

    Search CenterWatch for drugs/clinical trials and news about ZFAND3 / ZFAN3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFAND3 gene: 
    NM_021943.2  

    Unigene Cluster for ZFAND3:

    Zinc finger, AN1-type domain 3
    Hs.36959  [show with all ESTs]
    Unigene Representative Sequence: NM_021943
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287218(uc003onx.3) ENST00000373391 ENST00000474522 ENST00000373389
    ENST00000469208 ENST00000440482 ENST00000463847
    miRNA
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    8/73 QIAGEN miScript miRNA Assays for microRNAs that regulate ZFAND3 (see all 73):
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    SwitchGear 3'UTR luciferase reporter plasmidZFAND3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK023284.1 AK310757.1 AL137302.1 BC031481.2 

    13 DOTS entries:

    DT.95192871  DT.448167  DT.100793832  DT.86841488  DT.100793831  DT.91691331  DT.100793835  DT.121380405 
    DT.121380479  DT.92414487  DT.92434806  DT.95192884  DT.455566 

    24/328 AceView cDNA sequences (see all 328):

    BX281559 AI249251 AI056510 BM838794 BM976162 BM846494 AI129174 CR600723 
    BI793177 AI632718 AW068381 BQ638173 BM141863 AI361651 BQ128323 CR617176 
    CB119626 BI519988 BE906567 AI017706 BU902089 BU902208 AI142847 Z42477 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND3 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e
    SP1:        -                 -     -                 -           -     -                                 
    SP2:        -                                                                                             
    SP3:                          -     -                 -     -     -     -                                 
    SP4:                                                  -                                                   
    SP5:                                            -     -           -     -                                 


    ECgene alternative splicing isoforms for ZFAND3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFAND3 expression in normal human tissues (normalized intensities)      ZFAND3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCGCTTCCT
    ZFAND3 Expression
    About this image


    ZFAND3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Testis (Reproductive System)
             sperm   
     
     Adipose (Muscoskeletal System)
             epididymal fat pads   

    See ZFAND3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFAND3

    SOURCE GeneReport for Unigene cluster: Hs.36959
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZFAND3 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfand31 , 5 zinc finger, AN1-type domain 31, 5 91.71(n)1
    95.12(a)1
      17 (15.59 cM)5
    217691  NM_148926.21  NP_683728.11 
     300050875 
    chicken
    (Gallus gallus)
    Aves ZFAND31 zinc finger, AN1-type domain 3 83.33(n)
    88.38(a)
      421430  XM_419483.3  XP_419483.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZFAND36
    Zinc finger AN1-type domain 3
    82(a)
    1 ↔ 1
    1(229525604-229707508)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.242002 Xenopus laevis transcribed sequence with moderate similarity more 81.62(n)    CF548372.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj17a092 Transcribed sequence with weak similarity to protein more 78.31(n)    57092872 


    ENSEMBL Gene Tree for ZFAND3 (if available)
    TreeFam Gene Tree for ZFAND3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6766 SNPs in ZFAND3 are shown (see all 6766)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs563494611,2
    C--37751010(+) TTTTT-/T/TTT 
            
    AATAT
    1 -- int11NA 2
    rs105252521,2
    C--37777822(+) ttttt-/T/TTT/TT
    TTT
    /TTTTTT
    GGTGG
    2 -- int1 cds11NA 2
    rs1472362131,2
    --37785350(+) AACTCA/CAAGGC 1 -- us2k10--------
    rs1835143801,2
    --37785364(+) TAAGTA/GTCTCA 1 -- us2k10--------
    rs1439462671,2
    --37785467(+) ATGCA-/TTTTTT 1 -- us2k10--------
    rs1819781,2
    C,F,A--37785474(+) TTTTTT/CTTTCT 1 -- us2k1 trp38Minor allele frequency- C:0.39NA WA EA 368
    rs1407351191,2
    --37785485(+) TTCTTC/TCTTTT 1 -- us2k10--------
    rs69081061,2
    C,F,A,H--37785490(+) tctttT/Atttga 1 -- us2k1 trp39Minor allele frequency- A:0.23NS EA NA WA CSA 661
    rs1880958681,2
    --37785510(+) TCGCTC/TTCGCT 1 -- us2k10--------
    rs1497787331,2
    --37785549(+) ATGATC/TTCGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZFAND3 (37787275 - 38037275 bp, first 250kb of ZFAND3)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for ZFAND3 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2731942CNV Deletion23290073
    esv2731939CNV Deletion23290073
    esv2731944CNV Deletion23290073
    esv2668461CNV Deletion23128226
    esv2731945CNV Deletion23290073
    esv2731943CNV Deletion23290073
    esv989910CNV Deletion20482838
    esv2731946CNV Deletion23290073
    esv990874CNV Deletion20482838
    esv2731938CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZFAND3 for disorders           About MalaCards
    OMIM gene information: 607455    OMIM disorders: --


    ZFAND3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZFAND3
    Human Genome Epidemiology (HuGE) Navigator: ZFAND3 (1 document)

    Export disorders for ZFAND3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFAND3 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ZFAND3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Meta-analysis of genome-wide association studies ident ifies eight new loci for type 2 diabetes in east Asians. (PubMed id 22158537)1, 4 Cho Y.S....Seielstad M. (2012)
    2. Genome-wide detection of allele specific copy number v ariation associated with insulin resistance in African Americans from the HyperG EN study. (PubMed id 21901158)1, 4 Irvin M.R....Arnett D.K. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. (PubMed id 19285159)1 Fenner B.J....Prehn J.H. (2009)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    9. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 60685 HGNC: 18019 AceView: TEX27 Ensembl:ENSG00000156639 euGenes: HUgn60685
    ECgene: ZFAND3 H-InvDB: ZFAND3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFAND3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFAND3 gene:
    Search GeneIP for patents involving ZFAND3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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