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Aliases for ZFAND2B Gene

Aliases for ZFAND2B Gene

  • Zinc Finger AN1-Type Containing 2B 2 3 5
  • Arsenite-Inducible RNA-Associated Protein-Like Protein 3 4
  • Zinc Finger, AN1-Type Domain 2B 2 3
  • AIRAP-Like Protein 3 4
  • AIRAPL 3 4
  • Arsenite Inducible RNA Associated Protein-Like 2
  • AN1-Type Zinc Finger Protein 2B 3
  • Zinc Finger, AN1-Type 2B 2

External Ids for ZFAND2B Gene

Previous GeneCards Identifiers for ZFAND2B Gene

  • GC02P219898
  • GC02P219780
  • GC02P220059
  • GC02P211924

Summaries for ZFAND2B Gene

Entrez Gene Summary for ZFAND2B Gene

  • This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for ZFAND2B Gene

ZFAND2B (Zinc Finger AN1-Type Containing 2B) is a Protein Coding gene. An important paralog of this gene is ZFAND2A.

Additional gene information for ZFAND2B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND2B Gene

Genomics for ZFAND2B Gene

GeneHancer (GH) Regulatory Elements for ZFAND2B Gene

Promoters and enhancers for ZFAND2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I219205 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.4 +12.1 12075 2.9 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZFAND2B GLB1L ABCB6 GC02M219219 PIR34268
GH02I219244 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 15.5 +54.9 54881 11.2 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 GLB1L TUBA4A STK16 ZFAND2B ANKZF1 ATG9A DNAJB2 MIR153-1 PTPRN ENSG00000230432
GH02I219514 Promoter/Enhancer 1.5 EPDnew ENCODE 12.3 +319.2 319205 0.2 PKNOX1 ATF1 ARNT TCF12 GATA2 ATF7 NCOA1 REST ZNF592 MEF2D ASIC4 ZFAND2B ANKZF1 LOC105373885 ENSG00000227432
GH02I219121 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.9 -70.2 -70168 7.2 CLOCK ATF1 FOXA2 ARID4B YBX1 TCF12 FOS ATF7 RUNX3 RXRA SLC23A3 NHEJ1 IHH LOC100129175 MIR375 FEV CRYBA2 LINC00608 RETREG2 CNPPD1
GH02I219070 Enhancer 1 ENCODE dbSUPER 9.2 -122.8 -122848 4 ELF3 FOXA2 MLX ZSCAN9 RAD21 RARA ZNF143 CREM THAP11 MIXL1 NHEJ1 SLC23A3 MIR375 LOC100129175 PTPRN ZFAND2B ENSG00000272644 RN7SL764P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZFAND2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZFAND2B gene promoter:

Genomic Locations for ZFAND2B Gene

Genomic Locations for ZFAND2B Gene
14,415 bases
Plus strand

Genomic View for ZFAND2B Gene

Genes around ZFAND2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND2B Gene

Proteins for ZFAND2B Gene

  • Protein details for ZFAND2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    AN1-type zinc finger protein 2B
    Protein Accession:
    Secondary Accessions:
    • Q8NB98

    Protein attributes for ZFAND2B Gene

    257 amino acids
    Molecular mass:
    28023 Da
    Quaternary structure:
    • Interacts (via VIM motif) with VCP. Upon exposure to arsenite, associates with proteasomes.

    Three dimensional structures from OCA and Proteopedia for ZFAND2B Gene

    Alternative splice isoforms for ZFAND2B Gene


neXtProt entry for ZFAND2B Gene

Post-translational modifications for ZFAND2B Gene

  • Ubiquitination at posLast=9999, isoforms=2125, isoforms=214, and posLast=250250

No data available for DME Specific Peptides for ZFAND2B Gene

Domains & Families for ZFAND2B Gene

Gene Families for ZFAND2B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZFAND2B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZFAND2B: view

No data available for UniProtKB/Swiss-Prot for ZFAND2B Gene

Function for ZFAND2B Gene

Phenotypes From GWAS Catalog for ZFAND2B Gene

Gene Ontology (GO) - Molecular Function for ZFAND2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFAND2B: view
genes like me logo Genes that share phenotypes with ZFAND2B: view

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND2B Gene

Localization for ZFAND2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFAND2B Gene

Endoplasmic reticulum.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFAND2B gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 4
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZFAND2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with ZFAND2B: view

Pathways & Interactions for ZFAND2B Gene

SuperPathways for ZFAND2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation IMP 24160817
genes like me logo Genes that share ontologies with ZFAND2B: view

No data available for Pathways by source and SIGNOR curated interactions for ZFAND2B Gene

Drugs & Compounds for ZFAND2B Gene

No Compound Related Data Available

Transcripts for ZFAND2B Gene

Unigene Clusters for ZFAND2B Gene

Zinc finger, AN1-type domain 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND2B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: -
SP8: - - - -
SP9: -

Relevant External Links for ZFAND2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFAND2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFAND2B Gene

Protein differential expression in normal tissues from HIPED for ZFAND2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.9), Platelet (15.4), Retina (12.8), and Pancreas (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFAND2B Gene

Protein tissue co-expression partners for ZFAND2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFAND2B Gene:


SOURCE GeneReport for Unigene cluster for ZFAND2B Gene:


Evidence on tissue expression from TISSUES for ZFAND2B Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZFAND2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFAND2B Gene

Orthologs for ZFAND2B Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFAND2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFAND2B 33 34
  • 99.44 (n)
(Canis familiaris)
Mammalia ZFAND2B 33 34
  • 90.82 (n)
(Bos Taurus)
Mammalia ZFAND2B 33 34
  • 90.4 (n)
(Mus musculus)
Mammalia Zfand2b 33 16 34
  • 89.11 (n)
(Rattus norvegicus)
Mammalia Zfand2b 33
  • 89.11 (n)
(Monodelphis domestica)
Mammalia ZFAND2B 34
  • 78 (a)
(Gallus gallus)
Aves ZFAND2B 34
  • 56 (a)
(Anolis carolinensis)
Reptilia ZFAND2B 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487091 33
  • 61.72 (n)
Str.9255 33
(Danio rerio)
Actinopterygii zfand2a 33 34
  • 60.26 (n)
zgc66295 33
fruit fly
(Drosophila melanogaster)
Insecta CG12795 33 34
  • 51.85 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002339 33
  • 51.05 (n)
(Caenorhabditis elegans)
Secernentea aip-1 33 34
  • 45.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5587 34
  • 41 (a)
Species where no ortholog for ZFAND2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFAND2B Gene

Gene Tree for ZFAND2B (if available)
Gene Tree for ZFAND2B (if available)

Paralogs for ZFAND2B Gene

Paralogs for ZFAND2B Gene

(2) SIMAP similar genes for ZFAND2B Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ZFAND2B: view

Variants for ZFAND2B Gene

Sequence variations from dbSNP and Humsavar for ZFAND2B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs387906910 pathogenic, Microphthalmia, isolated, with coloboma 7 219,210,036(+) G/C downstream_transcript_variant
rs1000043499 -- 219,204,919(+) A/T upstream_transcript_variant
rs1000548792 -- 219,206,105(+) G/A upstream_transcript_variant
rs1001552057 -- 219,207,047(+) G/C intron_variant
rs1001664944 -- 219,205,816(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZFAND2B Gene

Variant ID Type Subtype PubMed ID
esv1000230 CNV deletion 20482838
esv3893555 CNV loss 25118596

Variation tolerance for ZFAND2B Gene

Residual Variation Intolerance Score: 36.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZFAND2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND2B Gene

Disorders for ZFAND2B Gene

Additional Disease Information for ZFAND2B

No disorders were found for ZFAND2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND2B Gene

Publications for ZFAND2B Gene

  1. Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. (PMID: 18467495) Yun C … Ron D (Proceedings of the National Academy of Sciences of the United States of America 2008) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. An Interaction Landscape of Ubiquitin Signaling. (PMID: 28190767) Zhang X … Vermeulen M (Molecular cell 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZFAND2B Gene

Sources for ZFAND2B Gene

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