ZFAND2B Gene
protein-coding GIFtS: 47
GCID: GC02P220059
|
|
zinc finger, AN1-type domain 2B(Previous names: zinc finger, AN1-type 2B )
| |
Aliases
for ZFAND2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, AN1-Type Domain 2B1 2 | | AIRAPL1 2 3 5 | | Arsenite-Inducible RNA-Associated Protein-Like Protein2 3 | | AIRAP-Like Protein2 3 | | Zinc Finger, AN1-Type 2B1 | | AN1-Type Zinc Finger Protein 2B2 |
Export aliases for ZFAND2B gene to outside databasesPrevious GC identifers: GC02P219898 GC02P219780 GC02P211924 |
Summaries
for ZFAND2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZFAND2B:
This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded proteinlikely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternativelyspliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Aug2012)
|
Genomic Views
for ZFAND2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZFAND2B gene promoter:
c-Fos AP-1 GR-beta ATF-2 NF-kappaB AREB6 c-Jun NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZFAND2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFAND2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35ZFAND2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P220059: view genomic region
(about GC identifiers)
Start:
|
220,059,959 bp from pter |
End:
|
220,074,373 bp from pter |
Size:
|
14,415 bases |
Orientation:
|
plus strand |
|
Proteins
for ZFAND2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZFN2B_HUMAN, Q8WV99 (See
protein sequence)Recommended Name: AN1-type zinc finger protein 2B Size: 257 amino acids; 28023 Da
Subunit: Upon exposure to arsenite, associates with proteasomes (By similarity)
Subcellular location: Endoplasmic reticulum (By similarity)
1 PDB 3D structure from  and Proteopedia  for ZFAND2B:1X4V (3D)
Secondary accessions: Q8NB98Alternative splicing: 2 isoforms: Q8WV99-1 Q8WV99-2 Explore the universe of human proteins at neXtProt for ZFAND2B: NX_Q8WV99
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WV99
ZFAND2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001257927.1 NP_001257928.1 NP_620157.1
ENSEMBL proteins: ENSP00000400760 ENSP00000386824 ENSP00000386399 ENSP00000289528 ENSP00000409931 ENSP00000386847 ENSP00000387179 ENSP00000386898 ENSP00000386370 ENSP00000387312 ENSP00000388773 ENSP00000416138 ENSP00000411334
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005783 | endoplasmic reticulum |
IEA | -- |
ZFAND2B for ontologies About GeneDecksing
ZFAND2B Antibody Products:
Assay Products for ZFAND2B: |
Protein
Domains /
Families
for ZFAND2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZFAND2B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WV99ProtoNet protein and cluster: Q8WV99 1 Blocks protein family: IPB000058 Zn-finger
UniProtKB/Swiss-Prot: ZFN2B_HUMAN, Q8WV99Similarity: Contains 2 AN1-type zinc fingersSimilarity: Contains 2 UIM (ubiquitin-interacting motif) repeats |
Function
for ZFAND2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND2B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND2B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZFAND2B (NM_138802) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZFAND2B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFAND2B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND2B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZFAND2B for ontologies About GeneDecksing
|
Pathways & Interactions
for ZFAND2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFAND2B
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for ZFAND2B (Q8WV991, 2, 3 ENSP000002895284) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for ZFAND2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZFAND2B
Search CenterWatch for drugs/clinical trials and news about ZFAND2B / ZFN2B
|
Transcripts
for ZFAND2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZFAND2B gene (3 alternative transcripts): NM_001270998.1 NM_001270999.1 NM_138802.2 Unigene Cluster for ZFAND2B: Zinc finger, AN1-type domain 2B Hs.534540 [show with all ESTs]Unigene Representative Sequence: NM_13880218/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000436556 ENST00000409206 ENST00000409594(uc010fwd.1 uc002vjz.1)
ENST00000289528(uc002vka.3) ENST00000422255 ENST00000476713 ENST00000409412
ENST00000409097(uc010zkt.2) ENST00000409336 ENST00000486734 ENST00000409217
ENST00000468301 ENST00000409319 ENST00000489197 ENST00000448496 ENST00000464902(uc002vkb.1)
ENST00000469596 ENST00000475533
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND2B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZFAND2B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: BC018415.1 14 DOTS entries: DT.75103954 DT.95346407 DT.100027858 DT.95132505 DT.100783718 DT.100783716 DT.97818807 DT.100783719 DT.97811856 DT.40110835 DT.100682390 DT.92427901 DT.95359303 DT.97845032 24/171 AceView cDNA sequences (see all 171): AI688282 BE870176 W94177 BQ952387 BE932282 AI919315 BM769182 BE465466 CR625904 AI075142 BU609024 BC018415 BM723204 BQ638417 AW518152 BQ899351 AA995071 BM852092 BI912787 BU948344 BF222965 AJ707181 BM681525 NM_138802
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND2B (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | - | | | | - | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZFAND2B
|
Expression
for ZFAND2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZFAND2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCATCTCCCT
About this image
See ZFAND2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZFAND2B
SOURCE GeneReport for Unigene cluster: Hs.534540
SABiosciences Custom PCR Arrays for ZFAND2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZFAND2B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND2B |
Orthologs
for ZFAND2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZFAND2B gene from 7/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
ZFAND2B6 |
-- |
64(a) |
1 ↔ 1 |
1(95890157-95899845) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.92552 |
Transcribed sequence with weak similarity to protein more |
76(n) |
|
BX685075.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc662952 |
hypothetical protein MGC66295 |
74.38(n) |
|
393489 BC055589.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG127951 |
CG12795 |
51.93(n)
44.2(a) |
|
33561 NM_001103604.1 NP_001097074.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
aip-11 |
Protein AIP-1 |
49.74(n)
39.23(a) |
|
179898 NM_074078.2 NP_506479.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G574801 |
zinc finger AN1 and C2H2 domain-containing stress-associated more |
45.22(n)
38.85(a) |
|
824915 NM_115608.4 NP_191307.1 |
rice
(Oryza sativa) |
Liliopsida |
---- |
ZOS7-05 - C2H2 zinc finger protein, expressed |
25(a)22(a) |
many ↔ manymany ↔ many |
9(13153942-13154831) 7(22929770-22932290) |
ENSEMBL Gene Tree for ZFAND2B (if available)
TreeFam Gene Tree for ZFAND2B (if available) |
Paralogs
for ZFAND2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZFAND2B gene
- ZFAND12 ZFAND2A2
2 SIMAP similar genes for ZFAND2B using alignment to 9 protein entries: ZFN2B_HUMAN (see all proteins):ZFAND2A ZFAND1
ZFAND2B for paralogs About GeneDecksing
|
Genomic Variants
for ZFAND2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZFAND2B (220059959 - 220074373 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZFAND2B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZFAND2B |
|
Disorders
/ Diseases
for ZFAND2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZFAND2B for disorders About GeneDecksing
OMIM gene information: 613474
OMIM disorders: --
2  diseases for ZFAND2B: About MalaCardsalzheimer's disease malaria
Export disorders for ZFAND2B gene to outside databases
|
Publications
for ZFAND2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZFAND2B gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with ZFAND2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. (PubMed id 18467495)1, 3 Yun C....Ron D. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model. (PubMed id 19414486)1 Hassan W.M....Link C.D. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for ZFAND2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZFAND2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZFAND2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZFAND2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZFAND2B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZFAND2B gene:
Search GeneIP for patents involving ZFAND2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZFAND2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |
 |  |  |  | |
| | | | Search Tocris compounds for ZFAND2B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZFAND2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND2B |
|  |  |  | | | | ThermoFisher Antibodies for ZFAND2B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZFAND2B |
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