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Aliases for ZFAND2B Gene

Aliases for ZFAND2B Gene

  • Zinc Finger AN1-Type Containing 2B 2 3
  • Zinc Finger, AN1-Type Domain 2B 2 3 5
  • Arsenite-Inducible RNA-Associated Protein-Like Protein 3 4
  • AIRAP-Like Protein 3 4
  • AIRAPL 3 4
  • Arsenite Inducible RNA Associated Protein-Like 2
  • Zinc Finger, AN1-Type 2B 2

External Ids for ZFAND2B Gene

Previous GeneCards Identifiers for ZFAND2B Gene

  • GC02P219898
  • GC02P219780
  • GC02P220059
  • GC02P211924

Summaries for ZFAND2B Gene

Entrez Gene Summary for ZFAND2B Gene

  • This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for ZFAND2B Gene

ZFAND2B (Zinc Finger AN1-Type Containing 2B) is a Protein Coding gene. An important paralog of this gene is ZFAND2A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND2B Gene

Genomics for ZFAND2B Gene

Regulatory Elements for ZFAND2B Gene

Genomic Location for ZFAND2B Gene

Chromosome:
2
Start:
219,195,237 bp from pter
End:
219,209,651 bp from pter
Size:
14,415 bases
Orientation:
Plus strand

Genomic View for ZFAND2B Gene

Genes around ZFAND2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND2B Gene

Proteins for ZFAND2B Gene

  • Protein details for ZFAND2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV99-ZFN2B_HUMAN
    Recommended name:
    AN1-type zinc finger protein 2B
    Protein Accession:
    Q8WV99
    Secondary Accessions:
    • Q8NB98

    Protein attributes for ZFAND2B Gene

    Size:
    257 amino acids
    Molecular mass:
    28023 Da
    Quaternary structure:
    • Interacts (via VIM motif) with VCP. Upon exposure to arsenite, associates with proteasomes.

    Three dimensional structures from OCA and Proteopedia for ZFAND2B Gene

    Alternative splice isoforms for ZFAND2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFAND2B Gene

Proteomics data for ZFAND2B Gene at MOPED

Post-translational modifications for ZFAND2B Gene

  • Ubiquitination at Lys 99, Lys 125, Lys 214, and Lys 250
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZFAND2B Gene

Domains & Families for ZFAND2B Gene

Gene Families for ZFAND2B Gene

Protein Domains for ZFAND2B Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8WV99

UniProtKB/Swiss-Prot:

ZFN2B_HUMAN :
  • Contains 2 UIM (ubiquitin-interacting motif) domains.
  • Contains 2 AN1-type zinc fingers.
Domain:
  • Contains 2 UIM (ubiquitin-interacting motif) domains.
Similarity:
  • Contains 2 AN1-type zinc fingers.
genes like me logo Genes that share domains with ZFAND2B: view

Function for ZFAND2B Gene

Gene Ontology (GO) - Molecular Function for ZFAND2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ZFAND2B: view
genes like me logo Genes that share phenotypes with ZFAND2B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND2B Gene

Localization for ZFAND2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFAND2B Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFAND2B Gene COMPARTMENTS Subcellular localization image for ZFAND2B gene
Compartment Confidence
nucleus 4
cytosol 3
endoplasmic reticulum 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for ZFAND2B Gene

Pathways & Interactions for ZFAND2B Gene

SuperPathways for ZFAND2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND2B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZFAND2B Gene

Drugs & Compounds for ZFAND2B Gene

No Compound Related Data Available

Transcripts for ZFAND2B Gene

Unigene Clusters for ZFAND2B Gene

Zinc finger, AN1-type domain 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND2B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: -
SP8: - - - -
SP9: -

Relevant External Links for ZFAND2B Gene

GeneLoc Exon Structure for
ZFAND2B
ECgene alternative splicing isoforms for
ZFAND2B

Expression for ZFAND2B Gene

mRNA expression in normal human tissues for ZFAND2B Gene

Protein differential expression in normal tissues from HIPED for ZFAND2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.9), Platelet (15.4), Retina (12.8), and Pancreas (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFAND2B Gene



SOURCE GeneReport for Unigene cluster for ZFAND2B Gene Hs.534540

genes like me logo Genes that share expression patterns with ZFAND2B: view

Protein tissue co-expression partners for ZFAND2B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFAND2B Gene

Orthologs for ZFAND2B Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFAND2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZFAND2B 35
  • 90.4 (n)
  • 89.49 (a)
ZFAND2B 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFAND2B 35
  • 90.82 (n)
  • 92.75 (a)
ZFAND2B 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfand2b 35
  • 89.11 (n)
  • 90.27 (a)
Zfand2b 16
Zfand2b 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZFAND2B 35
  • 99.44 (n)
  • 99.58 (a)
ZFAND2B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfand2b 35
  • 89.11 (n)
  • 91.05 (a)
oppossum
(Monodelphis domestica)
Mammalia ZFAND2B 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFAND2B 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFAND2B 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487091 35
  • 61.72 (n)
  • 64.06 (a)
Str.9255 35
zebrafish
(Danio rerio)
Actinopterygii zfand2a 35
  • 60.26 (n)
  • 61.18 (a)
zgc66295 35
zfand2a 36
  • 53 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002339 35
  • 51.05 (n)
  • 49.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12795 35
  • 51.85 (n)
  • 44 (a)
CG12795 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea aip-1 35
  • 45.78 (n)
  • 34.94 (a)
aip-1 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5587 36
  • 41 (a)
OneToMany
Species with no ortholog for ZFAND2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFAND2B Gene

ENSEMBL:
Gene Tree for ZFAND2B (if available)
TreeFam:
Gene Tree for ZFAND2B (if available)

Paralogs for ZFAND2B Gene

Paralogs for ZFAND2B Gene

(2) SIMAP similar genes for ZFAND2B Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ZFAND2B: view

Variants for ZFAND2B Gene

Sequence variations from dbSNP and Humsavar for ZFAND2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs4674366 -- 219,208,044(+) GTAAT(G/T)GCAGC intron-variant
rs4674367 -- 219,208,130(+) CAACC(C/T)TACCC intron-variant
rs6714820 -- 219,207,081(+) GCGGA(C/G)AGGGA intron-variant
rs6744146 -- 219,205,875(+) aaTTA(A/T)ATTgg upstream-variant-2KB
rs10190834 -- 219,205,579(+) GAATA(G/T)TGGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZFAND2B Gene

Variant ID Type Subtype PubMed ID
nsv875868 CNV Gain 21882294
nsv875869 CNV Loss 21882294
nsv875870 CNV Gain+Loss 21882294
esv1000230 CNV Deletion 20482838

Variation tolerance for ZFAND2B Gene

Residual Variation Intolerance Score: 36.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFAND2B Gene

HapMap Linkage Disequilibrium report
ZFAND2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND2B Gene

Disorders for ZFAND2B Gene

Relevant External Links for ZFAND2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFAND2B

No disorders were found for ZFAND2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND2B Gene

Publications for ZFAND2B Gene

  1. Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. (PMID: 18467495) Yun C. … Ron D. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex. (PMID: 24160817) Glinka T. … Stanhill A. (Biochem. J. 2014) 3
  4. Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates. (PMID: 24811749) Besche H.C. … Goldberg A.L. (EMBO J. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ZFAND2B Gene

Sources for ZFAND2B Gene

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