Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZFAND2B Gene

Aliases for ZFAND2B Gene

  • Zinc Finger AN1-Type Containing 2B 2 3 5
  • Arsenite-Inducible RNA-Associated Protein-Like Protein 3 4
  • Zinc Finger, AN1-Type Domain 2B 2 3
  • AIRAP-Like Protein 3 4
  • AIRAPL 3 4
  • Arsenite Inducible RNA Associated Protein-Like 2
  • AN1-Type Zinc Finger Protein 2B 3
  • Zinc Finger, AN1-Type 2B 2

External Ids for ZFAND2B Gene

Previous GeneCards Identifiers for ZFAND2B Gene

  • GC02P219898
  • GC02P219780
  • GC02P220059
  • GC02P211924

Summaries for ZFAND2B Gene

Entrez Gene Summary for ZFAND2B Gene

  • This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for ZFAND2B Gene

ZFAND2B (Zinc Finger AN1-Type Containing 2B) is a Protein Coding gene. An important paralog of this gene is ZFAND2A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND2B Gene

Genomics for ZFAND2B Gene

Regulatory Elements for ZFAND2B Gene

Enhancers for ZFAND2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F219121 1.2 Ensembl ENCODE 9.9 -70.1 -70099 7.3 ATF1 ARID4B YBX1 FOS SP5 KAT8 SREBF1 MIER3 ETV4 RCOR2 SLC23A3 NHEJ1 IHH LOC100129175 MIR375 FEV CRYBA2 LINC00608 CNPPD1 FAM134A
GH02F219070 0.9 ENCODE 9.2 -122.8 -122848 4.0 ELF3 MLX ZSCAN9 RAD21 RARA GATA4 CREM MIXL1 THAP11 KLF11 NHEJ1 SLC23A3 LOC100129175 MIR375 PTPRN ZFAND2B ENSG00000272644 RN7SL764P
GH02F219142 0.7 ENCODE 10.2 -52.7 -52744 0.2 CTCF SIN3A MNT DPF2 RAD21 SREBF1 E2F1 JUND SMC3 FOSL2 IHH SLC23A3 LOC100129175 MIR375 FAM134A CNPPD1 PTPRN ZFAND2B RESP18 NHEJ1
GH02F219139 0.5 ENCODE 10.2 -54.5 -54492 2.7 PKNOX1 MTA2 IKZF1 TBX21 NHEJ1 SLC23A3 IHH LOC100129175 MIR375 CNPPD1 FAM134A CRYBA2 FEV LINC00608
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFAND2B on UCSC Golden Path with GeneCards custom track

Genomic Location for ZFAND2B Gene

219,195,237 bp from pter
219,209,651 bp from pter
14,415 bases
Plus strand

Genomic View for ZFAND2B Gene

Genes around ZFAND2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND2B Gene

Proteins for ZFAND2B Gene

  • Protein details for ZFAND2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    AN1-type zinc finger protein 2B
    Protein Accession:
    Secondary Accessions:
    • Q8NB98

    Protein attributes for ZFAND2B Gene

    257 amino acids
    Molecular mass:
    28023 Da
    Quaternary structure:
    • Interacts (via VIM motif) with VCP. Upon exposure to arsenite, associates with proteasomes.

    Three dimensional structures from OCA and Proteopedia for ZFAND2B Gene

    Alternative splice isoforms for ZFAND2B Gene


neXtProt entry for ZFAND2B Gene

Post-translational modifications for ZFAND2B Gene

  • Ubiquitination at Lys 99, Lys 125, Lys 214, and Lys 250
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZFAND2B Gene

Domains & Families for ZFAND2B Gene

Gene Families for ZFAND2B Gene

Protein Domains for ZFAND2B Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 2 UIM (ubiquitin-interacting motif) domains.
  • Contains 2 AN1-type zinc fingers.
  • Contains 2 UIM (ubiquitin-interacting motif) domains.
  • Contains 2 AN1-type zinc fingers.
genes like me logo Genes that share domains with ZFAND2B: view

Function for ZFAND2B Gene

Gene Ontology (GO) - Molecular Function for ZFAND2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFAND2B: view
genes like me logo Genes that share phenotypes with ZFAND2B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND2B Gene

Localization for ZFAND2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFAND2B Gene

Endoplasmic reticulum.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFAND2B gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 4
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for ZFAND2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with ZFAND2B: view

Pathways & Interactions for ZFAND2B Gene

SuperPathways for ZFAND2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation IMP 24160817
genes like me logo Genes that share ontologies with ZFAND2B: view

No data available for Pathways by source and SIGNOR curated interactions for ZFAND2B Gene

Transcripts for ZFAND2B Gene

Unigene Clusters for ZFAND2B Gene

Zinc finger, AN1-type domain 2B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND2B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: -
SP8: - - - -
SP9: -

Relevant External Links for ZFAND2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFAND2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZFAND2B Gene

Protein differential expression in normal tissues from HIPED for ZFAND2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.9), Platelet (15.4), Retina (12.8), and Pancreas (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZFAND2B Gene

Protein tissue co-expression partners for ZFAND2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZFAND2B Gene:


SOURCE GeneReport for Unigene cluster for ZFAND2B Gene:

genes like me logo Genes that share expression patterns with ZFAND2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFAND2B Gene

Orthologs for ZFAND2B Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFAND2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZFAND2B 34 35
  • 99.44 (n)
(Canis familiaris)
Mammalia ZFAND2B 34 35
  • 90.82 (n)
(Bos Taurus)
Mammalia ZFAND2B 34 35
  • 90.4 (n)
(Mus musculus)
Mammalia Zfand2b 34 16 35
  • 89.11 (n)
(Rattus norvegicus)
Mammalia Zfand2b 34
  • 89.11 (n)
(Monodelphis domestica)
Mammalia ZFAND2B 35
  • 78 (a)
(Gallus gallus)
Aves ZFAND2B 35
  • 56 (a)
(Anolis carolinensis)
Reptilia ZFAND2B 35
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487091 34
  • 61.72 (n)
Str.9255 34
(Danio rerio)
Actinopterygii zfand2a 34 35
  • 60.26 (n)
zgc66295 34
fruit fly
(Drosophila melanogaster)
Insecta CG12795 34 35
  • 51.85 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002339 34
  • 51.05 (n)
(Caenorhabditis elegans)
Secernentea aip-1 34 35
  • 45.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5587 35
  • 41 (a)
Species where no ortholog for ZFAND2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFAND2B Gene

Gene Tree for ZFAND2B (if available)
Gene Tree for ZFAND2B (if available)

Paralogs for ZFAND2B Gene

Paralogs for ZFAND2B Gene

(2) SIMAP similar genes for ZFAND2B Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ZFAND2B: view

Variants for ZFAND2B Gene

Sequence variations from dbSNP and Humsavar for ZFAND2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs387906910 Pathogenic 219,210,036(-) AGGCT(C/G)TGTTG downstream-variant-500B, reference, missense
rs10190834 -- 219,205,579(+) GAATA(G/T)TGGCT upstream-variant-2KB
rs1053289 -- 219,209,924(+) GGAAG(G/T)GGCCA downstream-variant-500B, utr-variant-3-prime
rs111986337 -- 219,205,784(+) ACCCG(G/T)GAAGC upstream-variant-2KB
rs112300028 -- 219,206,895(+) CCCGC(C/T)AGAGT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZFAND2B Gene

Variant ID Type Subtype PubMed ID
esv3893555 CNV loss 25118596
esv1000230 CNV deletion 20482838

Variation tolerance for ZFAND2B Gene

Residual Variation Intolerance Score: 36.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFAND2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND2B Gene

Disorders for ZFAND2B Gene

Relevant External Links for ZFAND2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZFAND2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND2B Gene

Publications for ZFAND2B Gene

  1. Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. (PMID: 18467495) Yun C. … Ron D. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling. (PMID: 26692333) Osorio F.G. … LA^pez-OtA-n C. (Nat. Med. 2016) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ZFAND2B Gene

Sources for ZFAND2B Gene

Loading form....