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Aliases for ZFAND2B Gene

Aliases for ZFAND2B Gene

  • Zinc Finger, AN1-Type Domain 2B 2 3
  • AIRAPL 3 4 6
  • Arsenite-Inducible RNA-Associated Protein-Like Protein 3 4
  • AIRAP-Like Protein 3 4
  • Arsenite Inducible RNA Associated Protein-Like 2
  • AN1-Type Zinc Finger Protein 2B 3
  • Zinc Finger, AN1-Type 2B 2

External Ids for ZFAND2B Gene

Previous GeneCards Identifiers for ZFAND2B Gene

  • GC02P219898
  • GC02P219780
  • GC02P220059
  • GC02P211924

Summaries for ZFAND2B Gene

Entrez Gene Summary for ZFAND2B Gene

  • This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for ZFAND2B Gene

ZFAND2B (Zinc Finger, AN1-Type Domain 2B) is a Protein Coding gene. An important paralog of this gene is ZFAND2A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND2B Gene

Genomics for ZFAND2B Gene

Regulatory Elements for ZFAND2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZFAND2B Gene

219,195,237 bp from pter
219,209,651 bp from pter
14,415 bases
Plus strand

Genomic View for ZFAND2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFAND2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND2B Gene

Proteins for ZFAND2B Gene

  • Protein details for ZFAND2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    AN1-type zinc finger protein 2B
    Protein Accession:
    Secondary Accessions:
    • Q8NB98

    Protein attributes for ZFAND2B Gene

    257 amino acids
    Molecular mass:
    28023 Da
    Quaternary structure:
    • Interacts (via VIM motif) with VCP. Upon exposure to arsenite, associates with proteasomes.

    Three dimensional structures from OCA and Proteopedia for ZFAND2B Gene

    Alternative splice isoforms for ZFAND2B Gene


neXtProt entry for ZFAND2B Gene

Proteomics data for ZFAND2B Gene at MOPED

Post-translational modifications for ZFAND2B Gene

  • Ubiquitination at Lys99, Lys125, Lys214, and Lys250
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZFAND2B Gene

Domains for ZFAND2B Gene

Gene Families for ZFAND2B Gene

Protein Domains for ZFAND2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 UIM (ubiquitin-interacting motif) domains.
  • Contains 2 AN1-type zinc fingers.
  • Contains 2 UIM (ubiquitin-interacting motif) domains.
  • Contains 2 AN1-type zinc fingers.
genes like me logo Genes that share domains with ZFAND2B: view

Function for ZFAND2B Gene

Gene Ontology (GO) - Molecular Function for ZFAND2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZFAND2B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFAND2B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZFAND2B Gene

Localization for ZFAND2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFAND2B Gene

Endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for ZFAND2B Gene COMPARTMENTS Subcellular localization image for ZFAND2B gene
Compartment Confidence
nucleus 3
cytosol 2
endoplasmic reticulum 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ZFAND2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with ZFAND2B: view

Pathways for ZFAND2B Gene

SuperPathways for ZFAND2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation IMP 24160817
genes like me logo Genes that share ontologies with ZFAND2B: view

No data available for Pathways by source for ZFAND2B Gene

Transcripts for ZFAND2B Gene

Unigene Clusters for ZFAND2B Gene

Zinc finger, AN1-type domain 2B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZFAND2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND2B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: -
SP8: - - - -
SP9: -

Relevant External Links for ZFAND2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFAND2B Gene

mRNA expression in normal human tissues for ZFAND2B Gene

Protein differential expression in normal tissues for ZFAND2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.9), Platelet (15.4), Retina (12.8), and Pancreas (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFAND2B Gene

SOURCE GeneReport for Unigene cluster for ZFAND2B Gene Hs.534540

genes like me logo Genes that share expressions with ZFAND2B: view

Expression partners for ZFAND2B Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZFAND2B Gene

Orthologs for ZFAND2B Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFAND2B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZFAND2B 35
  • 90.4 (n)
  • 89.49 (a)
  • 90 (a)
(Canis familiaris)
Mammalia ZFAND2B 35
  • 90.82 (n)
  • 92.75 (a)
  • 92 (a)
(Mus musculus)
Mammalia Zfand2b 35
  • 89.11 (n)
  • 90.27 (a)
Zfand2b 16
Zfand2b 36
  • 90 (a)
(Pan troglodytes)
Mammalia ZFAND2B 35
  • 99.44 (n)
  • 99.58 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfand2b 35
  • 89.11 (n)
  • 91.05 (a)
(Monodelphis domestica)
Mammalia ZFAND2B 36
  • 78 (a)
(Gallus gallus)
Aves ZFAND2B 36
  • 56 (a)
(Anolis carolinensis)
Reptilia ZFAND2B 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487091 35
  • 61.72 (n)
  • 64.06 (a)
Str.9255 35
(Danio rerio)
Actinopterygii zfand2a 35
  • 60.26 (n)
  • 61.18 (a)
zgc66295 35
zfand2a 36
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002339 35
  • 51.05 (n)
  • 49.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12795 35
  • 51.85 (n)
  • 44 (a)
CG12795 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea aip-1 35
  • 45.78 (n)
  • 34.94 (a)
aip-1 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5587 36
  • 41 (a)
Species with no ortholog for ZFAND2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFAND2B Gene

Gene Tree for ZFAND2B (if available)
Gene Tree for ZFAND2B (if available)

Paralogs for ZFAND2B Gene

Paralogs for ZFAND2B Gene

(2) SIMAP similar genes for ZFAND2B Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ZFAND2B: view

Variants for ZFAND2B Gene

Sequence variations from dbSNP and Humsavar for ZFAND2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs4674366 -- 219,208,044(+) GTAAT(G/T)GCAGC intron-variant
rs4674367 -- 219,208,130(+) CAACC(C/T)TACCC intron-variant
rs6714820 -- 219,207,081(+) GCGGA(C/G)AGGGA intron-variant
rs6744146 -- 219,205,875(+) aaTTA(A/T)ATTgg upstream-variant-2KB
rs10190834 -- 219,205,579(+) GAATA(G/T)TGGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZFAND2B Gene

Variant ID Type Subtype PubMed ID
nsv875868 CNV Gain 21882294
nsv875869 CNV Loss 21882294
nsv875870 CNV Gain+Loss 21882294
esv1000230 CNV Deletion 20482838

Relevant External Links for ZFAND2B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND2B Gene

Disorders for ZFAND2B Gene

No disorders were found for ZFAND2B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZFAND2B Gene

Publications for ZFAND2B Gene

  1. Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. (PMID: 18467495) Yun C. … Ron D. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for ZFAND2B Gene

Sources for ZFAND2B Gene

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