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ZFAND2B Gene

protein-coding   GIFtS: 49
GCID: GC02P220059

Zinc Finger, AN1-Type Domain 2B

(Previous names: zinc finger, AN1-type 2B)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, AN1-Type Domain 2B1 2     Arsenite Inducible RNA Associated Protein-Like1
AIRAPL2 3 5     Zinc Finger, AN1-Type 2B1
Arsenite-Inducible RNA-Associated Protein-Like Protein2 3     AN1-Type Zinc Finger Protein 2B2
AIRAP-Like Protein2 3     

External Ids:    HGNC: 252061   Entrez Gene: 1306172   Ensembl: ENSG000001585527   OMIM: 6134745   UniProtKB: Q8WV993   

Export aliases for ZFAND2B gene to outside databases

Previous GC identifers: GC02P219898 GC02P219780 GC02P211924


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZFAND2B Gene:
This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein
likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively
spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Aug
2012)

GeneCards Summary for ZFAND2B Gene:
ZFAND2B (zinc finger, AN1-type domain 2B) is a protein-coding gene. Diseases associated with ZFAND2B include alzheimer's disease, and malaria. An important paralog of this gene is ZFAND2A.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZFAND2B gene promoter:
         c-Fos   AP-1   GR-beta   ATF-2   NF-kappaB   AREB6   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZFAND2B promoter sequence
   Search Chromatin IP Primers for ZFAND2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZFAND2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

ZFAND2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFAND2B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P220059:  view genomic region     (about GC identifiers)

Start:
220,059,959 bp from pter      End:
220,074,373 bp from pter
Size:
14,415 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZFN2B_HUMAN, Q8WV99 (See protein sequence)
Recommended Name: AN1-type zinc finger protein 2B  
Size: 257 amino acids; 28023 Da
Subunit: Upon exposure to arsenite, associates with proteasomes (By similarity)
1 PDB 3D structure from and Proteopedia for ZFAND2B:
1X4V (3D)    
Secondary accessions: Q8NB98
Alternative splicing: 2 isoforms:  Q8WV99-1   Q8WV99-2   

Explore the universe of human proteins at neXtProt for ZFAND2B: NX_Q8WV99

Explore proteomics data for ZFAND2B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys99, Lys125, Lys214, Lys250
  • Modification sites at PhosphoSitePlus

  • See ZFAND2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257927.1  NP_001257928.1  NP_620157.1  

    ENSEMBL proteins: 
     ENSP00000400760   ENSP00000386824   ENSP00000386399   ENSP00000289528   ENSP00000409931  
     ENSP00000386847   ENSP00000387179   ENSP00000386898   ENSP00000386370   ENSP00000387312  
     ENSP00000388773   ENSP00000416138   ENSP00000411334  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFAND: Zinc fingers, AN1-type domain containing

    2 InterPro protein domains:
     IPR000058 Znf_AN1
     IPR003903 Ubiquitin-int_motif

    Graphical View of Domain Structure for InterPro Entry Q8WV99

    ProtoNet protein and cluster: Q8WV99

    1 Blocks protein domain: IPB000058 Zn-finger

    UniProtKB/Swiss-Prot: ZFN2B_HUMAN, Q8WV99
    Similarity: Contains 2 AN1-type zinc fingers
    Similarity: Contains 2 UIM (ubiquitin-interacting motif) repeats


    ZFAND2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding IEA--
         
    ZFAND2B for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZFN2B_HUMAN, Q8WV99: Endoplasmic reticulum (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    endoplasmic reticulum2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--

    ZFAND2B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZFAND2B
    Interactions:

        Search GeneGlobe Interaction Network for ZFAND2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for ZFAND2B (Q8WV991, 2, 3 ENSP000002895284) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAZAP2Q150381, 2, 3, ENSP000004049684EBI-747823,EBI-724310 MINT-67139 I2D: score=3 STRING: ENSP00000404968
    MRM1ENSP000002501564STRING: ENSP00000250156
    NPLOC4ENSP000003314874STRING: ENSP00000331487
    PSMD1ENSP000003094744STRING: ENSP00000309474
    PSMD14ENSP000003865414STRING: ENSP00000386541
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZFAND2B (ZFN2B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZFAND2B gene (3 alternative transcripts): 
    NM_001270998.1  NM_001270999.1  NM_138802.2  

    Unigene Cluster for ZFAND2B:

    Zinc finger, AN1-type domain 2B
    Hs.534540  [show with all ESTs]
    Unigene Representative Sequence: NM_138802
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000436556 ENST00000409206 ENST00000409594(uc010fwd.1 uc002vjz.1)
    ENST00000289528(uc002vka.3) ENST00000422255 ENST00000476713 ENST00000409412
    ENST00000409097(uc010zkt.2) ENST00000409336 ENST00000486734 ENST00000409217
    ENST00000468301 ENST00000409319 ENST00000489197 ENST00000448496 ENST00000464902(uc002vkb.1)
    ENST00000469596 ENST00000475533

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ZFAND2B:
    hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidZFAND2B 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: BC018415.1 

    14 DOTS entries:

    DT.75103954  DT.95346407  DT.100027858  DT.95132505  DT.100783718  DT.100783716  DT.97818807  DT.100783719 
    DT.97811856  DT.40110835  DT.100682390  DT.92427901  DT.95359303  DT.97845032 

    Selected AceView cDNA sequences (see all 171):

    BQ952387 AI805055 BQ130532 BQ649012 CA433621 AW518152 BC018415 BU948344 
    BE870176 BU195818 BM681525 BQ899351 NM_138802 AW778969 W94177 AI858102 
    BQ574449 BF222965 BM789108 BU943940 BQ638417 AI572014 AI688282 AI919315 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND2B (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
    SP1:                                -                             -     -                       -     -               
    SP2:                                -                             -     -                                             
    SP3:                                                              -     -                                             
    SP4:        -     -     -           -                                                                                 
    SP5:        -     -     -           -           -     -           -     -                                             


    ECgene alternative splicing isoforms for ZFAND2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZFAND2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATCTCCCT
    ZFAND2B Expression
    About this image

    ZFAND2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZFAND2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534540
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZFAND2B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfand2b1 , 5 zinc finger, AN1 type domain 2B1, 5 89.11(n)1
    90.27(a)1
      1 (38.61 cM)5
    688181  NM_026846.31  NP_081122.21 
     751686465 
    chicken
    (Gallus gallus)
    Aves ZFAND2B6
    zinc finger, AN1-type domain 2B
    56(a)
    1 ↔ 1
    7(21736096-21737808)
    lizard
    (Anolis carolinensis)
    Reptilia ZFAND2B6
    zinc finger, AN1-type domain 2B
    63(a)
    1 ↔ 1
    1(95890157-95902212)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.92552 Transcribed sequence with weak similarity to protein more 76(n)    BX685075.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc662952 hypothetical protein MGC66295 74.38(n)   393489  BC055589.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG127951 CG12795 51.85(n)
    44(a)
      33561  NM_001103604.1  NP_001097074.1 
    worm
    (Caenorhabditis elegans)
    Secernentea aip-11 aip-1 45.78(n)
    34.94(a)
      179898  NM_074078.3  NP_506479.1 


    ENSEMBL Gene Tree for ZFAND2B (if available)
    TreeFam Gene Tree for ZFAND2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZFAND2B gene
    ZFAND2A2  
    2 SIMAP similar genes for ZFAND2B using alignment to 9 protein entries:     ZFN2B_HUMAN (see all proteins):
    ZFAND2A    ZFAND1

    ZFAND2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZFAND2B (see all 132)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1422270971,2
    --220069713(+) GAGTGA/TCCCTC 3 -- us2k10--------
    rs763110071,2
    C,F--220069771(+) CTAGCG/AAGGTA 3 -- us2k12Minor allele frequency- A:0.09CSA WA 120
    rs1928194691,2
    C--220069811(+) CTACAG/TTTGCA 3 -- us2k10--------
    rs1840193401,2
    --220069908(+) TGTAAA/GGTGGG 3 -- us2k10--------
    rs1880092461,2
    --220069962(+) TACACA/GTTTCT 3 -- us2k10--------
    rs1809200781,2
    --220070262(+) AAGCAC/TTTATA 3 -- us2k10--------
    rs101908341,2
    C,F,A,H--220070301(+) GAATAG/TTGGCT 3 -- us2k122Minor allele frequency- T:0.30NS EA NA CSA WA 2334
    rs762502481,2
    C,F--220070575(+) CACTGT/CGTCTC 3 -- us2k12Minor allele frequency- C:0.05WA EA 238
    rs67441461,2
    C,F,A,H--220070597(+) aaTTAA/TATTgg 3 -- us2k18Minor allele frequency- T:0.28NA WA EA 370
    rs1861611831,2
    --220070752(+) TGAGCA/GCGGTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZFAND2B (220059959 - 220074373 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZFAND2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1000230CNV Deletion20482838
    nsv875869CNV Loss21882294
    nsv875868CNV Gain21882294
    nsv875870CNV Gain+Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZFAND2B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613474    OMIM disorders: --

    2 diseases for ZFAND2B:    
    About MalaCards
    alzheimer's disease    malaria


    ZFAND2B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for ZFAND2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZFAND2B gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ZFAND2B)
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    1. Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans. (PubMed id 18467495)1, 3 Yun C....Ron D. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex. (PubMed id 24160817)1 Glinka T....Stanhill A. (Biochem. J. 2014)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model. (PubMed id 19414486)1 Hassan W.M....Link C.D. (Hum. Mol. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 130617 HGNC: 25206 AceView: LOC130617 Ensembl:ENSG00000158552 euGenes: HUgn130617
    ECgene: ZFAND2B H-InvDB: ZFAND2B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZFAND2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZFAND2B gene:
    Search GeneIP for patents involving ZFAND2B

    GeneCards and IP:
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