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Aliases for ZFAND2A Gene

Aliases for ZFAND2A Gene

  • Zinc Finger AN1-Type Containing 2A 2 3 5
  • Arsenite Inducible RNA Associated Protein 2 3
  • Zinc Finger, AN1-Type Domain 2A 2 3
  • AN1-Type Zinc Finger Protein 2A 3
  • AIRAP 3

External Ids for ZFAND2A Gene

Previous GeneCards Identifiers for ZFAND2A Gene

  • GC07M000966
  • GC07M001159
  • GC07M001103

Summaries for ZFAND2A Gene

GeneCards Summary for ZFAND2A Gene

ZFAND2A (Zinc Finger AN1-Type Containing 2A) is a Protein Coding gene. An important paralog of this gene is ZFAND2B.

Additional gene information for ZFAND2A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND2A Gene

Genomics for ZFAND2A Gene

Regulatory Elements for ZFAND2A Gene

Enhancers for ZFAND2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H001100 1.5 FANTOM5 ENCODE dbSUPER 32.9 +59.6 59632 2.2 ELF3 FOXA2 ZSCAN9 RAD21 RARA YY1 THAP11 REST KAT8 TGIF2 LOC101927021 ZFAND2A LOC105375120 GPER1 C7orf50 MIR339 GPR146 ENSG00000225146 ADAP1 TMEM184A
GH07H001022 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.1 +134.3 134287 7.4 HDGF FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YBX1 YY1 ZNF143 LOC105375120 LOC101927021 CYP2W1 ZFAND2A COX19 INTS1 SUN1 GPER1 FAM20C MIR339
GH07H001136 1.1 ENCODE 28.9 +22.7 22711 2.5 HDGF PKNOX1 ZFP64 ARID4B SIN3A YY1 ZNF143 FOS SP3 CEBPZ LOC101927021 ZFAND2A DNAAF5 SUN1 ENSG00000225981 INTS1 ENSG00000242474 C7orf50 PIR54083
GH07H001065 1.4 Ensembl ENCODE dbSUPER 19.2 +94.5 94496 1.9 SIN3A ARID4B ZNF2 ZNF143 ZNF207 ATF7 RUNX3 REST PPARG ZNF592 LOC105375120 LOC101927021 ZFAND2A GPER1 GC07P001069 GC07M001041
GH07H001043 1.3 ENCODE dbSUPER 18.8 +116.0 116023 3 ATF1 ARNT ARID4B SIN3A BRCA1 YY1 TCF12 ZNF766 GLIS2 ZNF143 LOC105375120 ZFAND2A MIR339 CYP2W1 COX19 LOC101927021 C7orf50 GPER1 GPR146 PIR31890
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZFAND2A on UCSC Golden Path with GeneCards custom track

Promoters for ZFAND2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000207562 759 2001 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS PAF1 SP3

Genomic Locations for ZFAND2A Gene

Genomic Locations for ZFAND2A Gene
8,689 bases
Minus strand

Genomic View for ZFAND2A Gene

Genes around ZFAND2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND2A Gene

Proteins for ZFAND2A Gene

  • Protein details for ZFAND2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    AN1-type zinc finger protein 2A
    Protein Accession:
    Secondary Accessions:
    • A4D220

    Protein attributes for ZFAND2A Gene

    145 amino acids
    Molecular mass:
    16477 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZFAND2A Gene

Post-translational modifications for ZFAND2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFAND2A Gene

No data available for DME Specific Peptides for ZFAND2A Gene

Domains & Families for ZFAND2A Gene

Gene Families for ZFAND2A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZFAND2A Gene


Suggested Antigen Peptide Sequences for ZFAND2A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZFAND2A: view

No data available for UniProtKB/Swiss-Prot for ZFAND2A Gene

Function for ZFAND2A Gene

Phenotypes From GWAS Catalog for ZFAND2A Gene

Gene Ontology (GO) - Molecular Function for ZFAND2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZFAND2A: view
genes like me logo Genes that share phenotypes with ZFAND2A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND2A Gene

Localization for ZFAND2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFAND2A Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZFAND2A gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ZFAND2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZFAND2A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZFAND2A Gene

Pathways & Interactions for ZFAND2A Gene

SuperPathways for ZFAND2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZFAND2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA --
GO:0071243 cellular response to arsenic-containing substance IEA --
genes like me logo Genes that share ontologies with ZFAND2A: view

No data available for Pathways by source and SIGNOR curated interactions for ZFAND2A Gene

Drugs & Compounds for ZFAND2A Gene

No Compound Related Data Available

Transcripts for ZFAND2A Gene

Unigene Clusters for ZFAND2A Gene

Zinc finger, AN1-type domain 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND2A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for ZFAND2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZFAND2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZFAND2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZFAND2A Gene:


SOURCE GeneReport for Unigene cluster for ZFAND2A Gene:


Evidence on tissue expression from TISSUES for ZFAND2A Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZFAND2A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZFAND2A Gene

Orthologs for ZFAND2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZFAND2A Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZFAND2A 33 34
  • 86.57 (n)
(Rattus norvegicus)
Mammalia Zfand2a 33
  • 79.17 (n)
(Bos Taurus)
Mammalia ZFAND2A 33 34
  • 79.08 (n)
(Mus musculus)
Mammalia Zfand2a 33 16 34
  • 78.7 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
-- 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia ZFAND2A 34
  • 52 (a)
(Gallus gallus)
Aves ZFAND2A 33 34
  • 66.2 (n)
(Danio rerio)
Actinopterygii zfand2a 34
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12795 34
  • 30 (a)
(Caenorhabditis elegans)
Secernentea aip-1 34
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G57480 33
  • 46.17 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5587 34
  • 27 (a)
Species where no ortholog for ZFAND2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZFAND2A Gene

Gene Tree for ZFAND2A (if available)
Gene Tree for ZFAND2A (if available)

Paralogs for ZFAND2A Gene

Paralogs for ZFAND2A Gene

(1) SIMAP similar genes for ZFAND2A Gene using alignment to 4 proteins: Pseudogenes for ZFAND2A Gene

genes like me logo Genes that share paralogs with ZFAND2A: view

Variants for ZFAND2A Gene

Sequence variations from dbSNP and Humsavar for ZFAND2A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000015486 -- 1,161,610(+) CCCTT(-/CCTC)AAACC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000070686 -- 1,156,745(+) CAGCC(C/T)GAGCT intron-variant
rs1000156965 -- 1,148,808(+) ATTGC(A/G)CCTGG downstream-variant-500B
rs1000753917 -- 1,149,748(+) ACGGC(A/G)CTGCG utr-variant-3-prime
rs1000901204 -- 1,161,022(+) TGTCT(A/G)TGTGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZFAND2A Gene

Variant ID Type Subtype PubMed ID
nsv830876 CNV loss 17160897
nsv605735 CNV gain 21841781
nsv605705 CNV loss 21841781
nsv508441 CNV deletion 20534489
nsv471182 CNV loss 18288195
nsv1125423 OTHER inversion 24896259
nsv1032992 CNV gain 25217958
nsv1028941 CNV gain 25217958
esv3541018 CNV deletion 23714750
esv3541017 CNV deletion 23714750
esv2759499 CNV loss 17122850
esv2733730 CNV deletion 23290073
esv2733727 CNV deletion 23290073
esv2499925 CNV deletion 19546169
esv2110851 CNV deletion 18987734
esv1724460 CNV deletion 17803354
esv1295388 CNV deletion 17803354
dgv11119n54 CNV loss 21841781
dgv1062e201 CNV deletion 23290073

Variation tolerance for ZFAND2A Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFAND2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND2A Gene

Disorders for ZFAND2A Gene

Relevant External Links for ZFAND2A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZFAND2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND2A Gene

Publications for ZFAND2A Gene

  1. AIRAP, a new human heat shock gene regulated by heat shock factor 1. (PMID: 20185824) Rossi A … Santoro MG (The Journal of biological chemistry 2010) 2 3 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The proteasome inhibitor bortezomib is a potent inducer of zinc finger AN1-type domain 2a gene expression: role of heat shock factor 1 (HSF1)-heat shock factor 2 (HSF2) heterocomplexes. (PMID: 24619424) Rossi A … Santoro MG (The Journal of biological chemistry 2014) 3 60
  4. Stress-induced start codon fidelity regulates arsenite-inducible regulatory particle-associated protein (AIRAP) translation. (PMID: 24898249) Zach L … Stanhill A (The Journal of biological chemistry 2014) 3 60
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3 60

Products for ZFAND2A Gene

Sources for ZFAND2A Gene

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