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Aliases for ZFAND2A Gene

Aliases for ZFAND2A Gene

  • Zinc Finger AN1-Type Containing 2A 2 3
  • Zinc Finger, AN1-Type Domain 2A 2 3 5
  • Arsenite Inducible RNA Associated Protein 2 3
  • AIRAP 3

External Ids for ZFAND2A Gene

Previous GeneCards Identifiers for ZFAND2A Gene

  • GC07M000966
  • GC07M001159
  • GC07M001103

Summaries for ZFAND2A Gene

GeneCards Summary for ZFAND2A Gene

ZFAND2A (Zinc Finger AN1-Type Containing 2A) is a Protein Coding gene. An important paralog of this gene is ZFAND2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFAND2A Gene

Genomics for ZFAND2A Gene

Regulatory Elements for ZFAND2A Gene

Promoters for ZFAND2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZFAND2A on UCSC Golden Path with GeneCards custom track

Genomic Location for ZFAND2A Gene

Chromosome:
7
Start:
1,152,071 bp from pter
End:
1,160,759 bp from pter
Size:
8,689 bases
Orientation:
Minus strand

Genomic View for ZFAND2A Gene

Genes around ZFAND2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZFAND2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZFAND2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFAND2A Gene

Proteins for ZFAND2A Gene

  • Protein details for ZFAND2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6M9-ZFN2A_HUMAN
    Recommended name:
    AN1-type zinc finger protein 2A
    Protein Accession:
    Q8N6M9
    Secondary Accessions:
    • A4D220

    Protein attributes for ZFAND2A Gene

    Size:
    145 amino acids
    Molecular mass:
    16477 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZFAND2A Gene

Proteomics data for ZFAND2A Gene at MOPED

Post-translational modifications for ZFAND2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFAND2A Gene

No data available for DME Specific Peptides for ZFAND2A Gene

Domains & Families for ZFAND2A Gene

Gene Families for ZFAND2A Gene

Protein Domains for ZFAND2A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZFAND2A Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6M9

UniProtKB/Swiss-Prot:

ZFN2A_HUMAN :
  • Contains 2 AN1-type zinc fingers.
Similarity:
  • Contains 2 AN1-type zinc fingers.
genes like me logo Genes that share domains with ZFAND2A: view

Function for ZFAND2A Gene

Gene Ontology (GO) - Molecular Function for ZFAND2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ZFAND2A: view
genes like me logo Genes that share phenotypes with ZFAND2A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZFAND2A Gene

Localization for ZFAND2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFAND2A Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFAND2A Gene COMPARTMENTS Subcellular localization image for ZFAND2A gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ZFAND2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZFAND2A: view

Pathways & Interactions for ZFAND2A Gene

SuperPathways for ZFAND2A Gene

No Data Available

Interacting Proteins for ZFAND2A Gene

Gene Ontology (GO) - Biological Process for ZFAND2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZFAND2A Gene

Drugs & Compounds for ZFAND2A Gene

No Compound Related Data Available

Transcripts for ZFAND2A Gene

Unigene Clusters for ZFAND2A Gene

Zinc finger, AN1-type domain 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND2A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for ZFAND2A Gene

GeneLoc Exon Structure for
ZFAND2A
ECgene alternative splicing isoforms for
ZFAND2A

Expression for ZFAND2A Gene

mRNA expression in normal human tissues for ZFAND2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZFAND2A Gene Hs.648111

genes like me logo Genes that share expression patterns with ZFAND2A: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZFAND2A Gene

Orthologs for ZFAND2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZFAND2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZFAND2A 36
  • 59 (a)
OneToOne
ZFAND2A 35
  • 79.08 (n)
  • 70.34 (a)
dog
(Canis familiaris)
Mammalia ZFAND2A 35
  • 86.57 (n)
  • 85.42 (a)
ZFAND2A 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfand2a 16
Zfand2a 36
  • 64 (a)
OneToOne
Zfand2a 35
  • 78.7 (n)
  • 77.08 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ZFAND2A 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfand2a 35
  • 79.17 (n)
  • 76.39 (a)
chicken
(Gallus gallus)
Aves ZFAND2A 35
  • 66.2 (n)
  • 62.94 (a)
ZFAND2A 36
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zfand2a 36
  • 33 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12795 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea aip-1 36
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G57480 35
  • 46.17 (n)
  • 40.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5587 36
  • 27 (a)
OneToMany
Species with no ortholog for ZFAND2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZFAND2A Gene

ENSEMBL:
Gene Tree for ZFAND2A (if available)
TreeFam:
Gene Tree for ZFAND2A (if available)

Paralogs for ZFAND2A Gene

Paralogs for ZFAND2A Gene

(1) SIMAP similar genes for ZFAND2A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ZFAND2A Gene

genes like me logo Genes that share paralogs with ZFAND2A: view

Variants for ZFAND2A Gene

Sequence variations from dbSNP and Humsavar for ZFAND2A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17855544 - 1,155,577(+) GGACG(A/T)GAACA reference, missense
rs6970581 -- 1,152,452(+) TGGAC(A/G)CCAGA downstream-variant-500B
rs6975049 -- 1,152,802(+) CGCCT(C/G)GACCT downstream-variant-500B
rs7781581 -- 1,155,628(+) GCAAC(C/T)TAAAC intron-variant
rs7785234 -- 1,155,738(+) GGTCA(C/T)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFAND2A Gene

Variant ID Type Subtype PubMed ID
dgv7074n71 CNV Loss 21882294
nsv887128 CNV Loss 21882294
dgv7080n71 CNV Loss 21882294
nsv887141 CNV Loss 21882294
dgv7083n71 CNV Loss 21882294
dgv7087n71 CNV Loss 21882294
nsv482917 CNV Loss 15286789
nsv830876 CNV Loss 17160897
nsv508441 CNV Loss 20534489
nsv471182 CNV Loss 18288195
esv2499925 CNV Deletion 19546169
esv2110851 CNV Deletion 18987734
esv2733727 CNV Deletion 23290073
esv1295388 CNV Deletion 17803354
dgv2045e1 CNV Complex 17122850
dgv1109e201 CNV Deletion 23290073
esv2733730 CNV Deletion 23290073
esv1724460 CNV Deletion 17803354

Variation tolerance for ZFAND2A Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZFAND2A Gene

HapMap Linkage Disequilibrium report
ZFAND2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFAND2A Gene

Disorders for ZFAND2A Gene

Relevant External Links for ZFAND2A

Genetic Association Database (GAD)
ZFAND2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZFAND2A

No disorders were found for ZFAND2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZFAND2A Gene

Publications for ZFAND2A Gene

  1. AIRAP, a new human heat shock gene regulated by heat shock factor 1. (PMID: 20185824) Rossi A. … Santoro M.G. (J. Biol. Chem. 2010) 2 3 67
  2. The proteasome inhibitor bortezomib is a potent inducer of zinc finger AN1-type domain 2a gene expression: role of heat shock factor 1 (HSF1)-heat shock factor 2 (HSF2) heterocomplexes. (PMID: 24619424) Rossi A. … Santoro M.G. (J. Biol. Chem. 2014) 3
  3. Stress-induced start codon fidelity regulates arsenite-inducible regulatory particle-associated protein (AIRAP) translation. (PMID: 24898249) Zach L. … Stanhill A. (J. Biol. Chem. 2014) 3
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for ZFAND2A Gene

Sources for ZFAND2A Gene

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