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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZFAND2A Gene

protein-coding   GIFtS: 44
GCID: GC07M001191

Zinc Finger, AN1-Type Domain 2A

  Search for ZFAND2A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, AN1-Type Domain 2A1 2
Arsenite Inducible RNA Associated Protein1 2
AIRAP2 5
AN1-Type Zinc Finger Protein 2A2

External Ids:    HGNC: 280731   Entrez Gene: 906372   Ensembl: ENSG000001783817   OMIM: 6106995   UniProtKB: Q8N6M93   

Export aliases for ZFAND2A gene to outside databases

Previous GC identifers: GC07M000966 GC07M001159 GC07M001103


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZFAND2A Gene: 
ZFAND2A (zinc finger, AN1-type domain 2A) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is ZFAND2B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZFAND2A gene promoter:
         AML1a   GATA-3   C/EBPalpha   CREB   CHOP-10   c-Rel   FOXO1a   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ZFAND2A promoter sequence
   Search SABiosciences Chromatin IP Primers for ZFAND2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZFAND2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22.3

ZFAND2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZFAND2A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M001191:  view genomic region     (about GC identifiers)

Start:
1,191,707 bp from pter      End:
1,200,395 bp from pter
Size:
8,689 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 1,245,778-1,252,683     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZFN2A_HUMAN, Q8N6M9 (See protein sequence)
Recommended Name: AN1-type zinc finger protein 2A  
Size: 145 amino acids; 16477 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: A4D220

Explore the universe of human proteins at neXtProt for ZFAND2A: NX_Q8N6M9

Explore proteomics data for ZFAND2A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N6M9

  • ZFAND2A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZFAND2A Protein Expression
    REFSEQ proteins: NP_872297.2  
    ENSEMBL proteins: 
     ENSP00000386031   ENSP00000380273   ENSP00000314619   ENSP00000459173  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    ZFAND2A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZFAND: Zinc fingers, AN1-type domain containing

    1 InterPro protein domain:
     IPR000058 Znf_AN1

    Graphical View of Domain Structure for InterPro Entry Q8N6M9

    ProtoNet protein and cluster: Q8N6M9

    2 Blocks protein domains:
    IPB000058 Zn-finger
    IPB003615 HNH nuclease


    UniProtKB/Swiss-Prot: ZFN2A_HUMAN, Q8N6M9
    Similarity: Contains 2 AN1-type zinc fingers


    ZFAND2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
         
    ZFAND2A for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Zfand2a):
     cellular 

    ZFAND2A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZFAND2A 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZFAND2A 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZFAND2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for ZFAND2A (ENSP000003146194) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL30ENSP000002870384STRING: ENSP00000287038
    PSMD2ENSP000003101294STRING: ENSP00000310129
    PSMD1ENSP000003094744STRING: ENSP00000309474
    PSMD7ENSP000002193134STRING: ENSP00000219313
    PSMD14ENSP000003865414STRING: ENSP00000386541
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZFAND2A (ZFN2A)

    Search CenterWatch for drugs/clinical trials and news about ZFAND2A / ZFN2A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZFAND2A gene: 
    NM_182491.2  

    Unigene Cluster for ZFAND2A:

    Zinc finger, AN1-type domain 2A
    Hs.648111  [show with all ESTs]
    Unigene Representative Sequence: AK123998
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401903 ENST00000397083 ENST00000316495(uc003skc.3 uc003skd.4)
    ENST00000471448 ENST00000574135 ENST00000484977 ENST00000478137
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Products:
        
    OriGene qPCR primer pairs and template standards for ZFAND2A
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZFAND2A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZFAND2A

    Additional mRNA sequence: 

    AK027118.1 AK096735.1 AK123998.1 AK290170.1 BC016963.1 BC029558.1 

    6 DOTS entries:

    DT.209740  DT.99985064  DT.100776038  DT.121056074  DT.121056116  DT.95365054 

    24/72 AceView cDNA sequences (see all 72):

    AI494331 AL705357 CF528988 BF437234 AA729847 AA994940 CF594317 CA865571 
    AI269072 CA865826 AI571383 BQ054367 AA470778 AI890242 AI082007 CF528532 
    BQ011643 BQ011825 BU621070 CA454607 BE699264 CA307010 BP872998 AI338453 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZFAND2A    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6
    SP1:                                      -           -     -                 -         
    SP2:                                      -           -     -                           
    SP3:                                      -           -                                 
    SP4:                                      -                                             
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ZFAND2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZFAND2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTGGAAGCA
    ZFAND2A Expression
    About this image


    See ZFAND2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZFAND2A

    SOURCE GeneReport for Unigene cluster: Hs.648111
        SABiosciences Custom PCR Arrays for ZFAND2A
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZFAND2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ZFAND2A gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfand2a1 , 5 zinc finger, AN1-type domain 2A1, 5 79.71(n)1
    80.43(a)1
      5 (78.68 cM)5
    1004941  NM_001159908.11  NP_001153380.11 
     1394712115 
    chicken
    (Gallus gallus)
    Aves ZFAND2A1 zinc finger, AN1-type domain 2A 66.2(n)
    62.94(a)
      425104  XM_422896.3  XP_422896.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zfand2a6
    zinc finger, AN1-type domain 2A
    33(a)
    1 → many
    3(43222242-43241628)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG127956
    --
    30(a)
    1 → many
    2L(3452451-3453596)
    worm
    (Caenorhabditis elegans)
    Secernentea aip-16
    Protein AIP-1
    29(a)
    1 → many
    V(14012333-14013644)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YNL155W6
    Putative protein of unknown function; contains a D...
    9(a)
    1 → many
    XIV(342516-343340)


    ENSEMBL Gene Tree for ZFAND2A (if available)
    TreeFam Gene Tree for ZFAND2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZFAND2A gene
    ZFAND2B2  
    1 SIMAP similar gene for ZFAND2A using alignment to 4 protein entries:     ZFN2A_HUMAN (see all proteins):
    ZFAND2B

    ZFAND2A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZFAND2A
    PGOHUM00000248124 PGOHUM00000237717


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/378 SNPs in ZFAND2A are shown (see all 378)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69705811,2
    C,F--1192088(+) TGGACG/ACCAGA 1 -- int19Minor allele frequency- A:0.18NA WA CSA 252
    rs69705871,2
    C,F--1192105(+) CAGGTG/CCAACA 1 -- int19Minor allele frequency- C:0.17NA WA CSA 252
    rs1465026581,2
    --1192171(+) ATCATA/GTCCCC 1 -- int10--------
    rs1901285571,2
    --1192249(+) CAGAGG/TTCACG 1 -- int10--------
    rs69708671,2
    C,F--1192291(+) AAAAGG/AGGAAG 1 -- int17Minor allele frequency- A:0.13NA WA CSA 248
    rs102429601,2
    C,F--1192307(+) acacaC/Aacaga 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1408821751,2
    --1192339(+) GGAGAC/TGGGGG 1 -- int10--------
    rs1830822781,2
    --1192340(+) GAGACA/GGGGGT 1 -- int10--------
    rs1130390121,2
    F--1192346(+) GGGGTT/CGTGCA 1 -- int12Minor allele frequency- C:0.05CSA NA 123
    rs1876277461,2
    --1192434(+) CCTGCA/GCCTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZFAND2A (1191707 - 1200395 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for ZFAND2A (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2733730CNV Deletion23290073
    esv2499925CNV Deletion19546169
    dgv1109e201CNV Deletion23290073
    esv1724460CNV Deletion17803354
    esv2110851CNV Deletion18987734
    esv1295388CNV Deletion17803354
    esv2733727CNV Deletion23290073
    nsv830876CNV Loss17160897
    dgv7083n71CNV Loss21882294
    nsv508441CNV Loss20534489

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZFAND2A for disorders           About MalaCards
    OMIM gene information: 610699    OMIM disorders: --


    ZFAND2A for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZFAND2A

    Export disorders for ZFAND2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZFAND2A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZFAND2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. AIRAP, a new human heat shock gene regulated by heat shock factor 1. (PubMed id 20185824)1, 3 Rossi A....Santoro M.G. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    5. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90637 HGNC: 28073 AceView: LOC90637 Ensembl:ENSG00000178381 euGenes: HUgn90637
    ECgene: ZFAND2A H-InvDB: ZFAND2A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZFAND2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZFAND2A gene:
    Search GeneIP for patents involving ZFAND2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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